musculoskeletal system disease: A disease involving the musculoskeletal system. [database_cross_reference: MONDO:DesignPattern]
Other acquired deformities of musculoskeletal system and connective tissue
DOID EFO Endpoint Browser PheWeb
M13_DEFORMACQ
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1785 |
4. Check minimum number of eventsNone |
1785 |
5. Include endpointsNone |
1785 |
6. Filter based on genotype QC (FinnGen only) |
1785 |
Control definitions (FinnGen only)
- Control exclude
- M13_MUSCULOSKELEOTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M95-M99
- Name in latin
- Aliae deformitates acquisitae systematis musculosceletalis et textus connectivi
Similar endpoints
↥List of similar endpoints to
Other acquired deformities of musculoskeletal system and connective tissue
based on the number of shared cases.
Similar with more cases:
- Other disorders of the musculoskeletal system and connective tissue
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 14910 | 6894 | 7861 |
| Only index persons | 13114 | 6054 | 7060 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.21 | 0.20 | 0.22 |
| Only index persons | 0.25 | 0.22 | 0.27 |
| Median age at first event (years) | |||
| Whole population | 38.29 | 40.56 | 36.21 |
| Only index persons | 36.64 | 38.52 | 35.04 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1785 | 920 | 865 |
| Unadjusted period prevalence (%) | 0.35 | 0.31 | 0.38 |
| Median age at first event (years) | 39.65 | 38.06 | 41.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1611
- Matched controls
- 16109
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M95.0
ICD-10 Finland
Acquired deformity of nose
+∞
323.0
734
*
73808
ICD-8 Finland
Other deformities, Aliae definitae
+∞
323.0
325
*
DLD20
NOMESCO Finland
Rhinoplasty
1372.0
247.4
235
*
DLD10
NOMESCO Finland
Reconstruction of cartilage and bone of nose
370.6
196.1
194
6
J34.2
ICD-10 Finland
Deviated nasal septum
10.4
174.7
369
446
7384A
ICD-9 Finland
Other acquired deformity, Acquired spondylolisthesis
+∞
174.1
164
*
73809
ICD-8 Finland
Other deformities, Unspecified
+∞
145.0
137
*
DJD20
NOMESCO Finland
Plastic repair of septum of nose
9.5
111.7
243
295
DLD00
NOMESCO Finland
Reconstruction of cartilage of nose
283.8
105.1
106
*
M95.8
ICD-10 Finland
Other specified acquired deformities of musculoskeletal system
395.3
76.4
76
*
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
12.5
72.5
134
116
ZZG00
NOMESCO Finland
Graft of cartilage
118.2
63.3
68
6
7380A
ICD-9 Finland
Other acquired deformity, Acquired deformity of nose
+∞
57.6
55
*
9183
FHL
Posterolateral spondylodesis
124.5
56.2
60
5
7385A
ICD-9 Finland
Other acquired deformity of back or spine
+∞
51.3
49
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
41.2
509
2731
DHB50
NOMESCO Finland
Turbinoplasty
6.7
40.0
105
165
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
39.8
643
3871
M95.9
ICD-10 Finland
Acquired deformity of musculoskeletal system, unspecified
+∞
39.7
38
*
DHD10
NOMESCO Finland
Closed reduction of fracture of nose
18.1
39.1
61
35
N02AX02
ATC
tramadol; systemic, rectal
2.0
35.9
731
4771
ZXD10
NOMESCO Finland
Scheduled procedure
1.9
28.8
635
4164
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
28.6
775
5442
N03AX16
ATC
pregabalin; oral
2.0
27.2
408
2306
J34.3
ICD-10 Finland
Hypertrophy of nasal turbinates
6.0
25.7
72
124
73799
ICD-8 Finland
Hallux valgus and varus
6.3
25.3
68
111
2309
FHL
Other measure in this category
71.0
24.8
28
*
R01AD09
ATC
mometasone; nasal
1.7
24.5
720
5098
J01DB01
ATC
cefalexin; oral
1.9
24.0
1302
11104
A02BC05
ATC
esomeprazole; systemic
1.7
23.0
652
4537
N06AX11
ATC
mirtazapine; oral
1.8
22.9
508
3275
J34.8
ICD-10 Finland
Other specified disorders of nose and nasal sinuses
11.0
22.7
43
40
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.9
22.0
144
532
ZXE00
NOMESCO Finland
One hour or less
1.7
21.9
622
4312
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
21.4
320
1786
M01AE03
ATC
ketoprofen; systemic, rectal
1.7
21.2
599
4137
M43.1
ICD-10 Finland
Spondylolisthesis
3.8
20.9
92
255
A02BC02
ATC
pantoprazole; systemic
1.7
20.8
991
7907
R06.0
ICD-10 Finland
Dyspnoea
1.9
20.1
374
2254
M95.4
ICD-10 Finland
Acquired deformity of chest and rib
+∞
19.8
19
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
19.8
656
4716
N02AJ06
ATC
codeine and paracetamol; systemic
1.7
19.6
594
4159
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
19.6
239
1222
4204
FHL
Molding of the cartilaginous part of the nose
202.2
19.6
20
*
ZXB10
NOMESCO Finland
Medial
17.0
19.2
30
18
H02AB06
ATC
prednisolone; systemic
1.6
19.1
713
5276
75618
ICD-8 Finland
Other congenital anomalies of musculoskeletal system, Maleformationes columnae vertebralis aliae
15.0
18.9
31
21
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
18.9
202
973
N02BE01
ATC
paracetamol; systemic, rectal
1.8
18.9
1338
11760
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.4
18.9
176
796
9212
FHL
Other posterior root decompression surgery (eg laminectomy, Gill)
13.6
18.7
32
24
DLW99
NOMESCO Finland
Other plastic operations on nose
101.2
18.6
20
*
R03AC02
ATC
salbutamol; inhalant
1.6
18.6
798
6112
N03AX12
ATC
gabapentin; oral
2.0
18.4
254
1368
4203
FHL
Mobilization and repositioning of the external pyramid
44.5
18.2
22
5
M01AB05
ATC
diclofenac; systemic, rectal
1.6
18.2
1051
8661
M79.6
ICD-10 Finland
Pain in limb
1.7
18.1
551
3843
R01AD08
ATC
fluticasone; nasal
1.7
17.9
455
3015
N06AX16
ATC
venlafaxine; oral
2.0
17.5
229
1205
4211
FHL
Transeptal septal resection and reconstruction
7.5
17.5
41
56
N05CF02
ATC
zolpidem; oral
1.9
17.4
285
1634
J31.0
ICD-10 Finland
Chronic rhinitis
2.5
17.2
146
628
M02AA07
ATC
piroxicam; topical
1.6
17.1
549
3869
N06AA09
ATC
amitriptyline; systemic
2.2
16.5
177
853
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.2
16.4
171
813
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
16.3
435
2905
N05BA04
ATC
oxazepam; oral
1.7
16.2
371
2370
4700A
ICD-9 Finland
Deflected nasal septum[DEFORMATIO SEPTI NASI]
5.8
16.1
45
79
4202
FHL
Forming an external pyramid without mobilization
60.6
15.8
18
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.5
15.5
125
524
X58
ICD-10 Finland
Exposure to other specified factors
1.9
15.5
232
1283
N06AB04
ATC
citalopram; systemic
1.8
15.4
331
2069
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
15.3
192
991
N06AX21
ATC
duloxetine; oral
2.1
15.2
175
870
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.5
15.2
72
214
WX110
NOMESCO Finland
Local anesthesy
1.5
14.9
1061
8947
M54.5
ICD-10 Finland
Low back pain
1.6
14.8
497
3515
A02BC01
ATC
omeprazole; systemic
1.7
14.7
405
2718
ZXA05
NOMESCO Finland
Left side
1.7
14.7
386
2555
WX002
NOMESCO Finland
Sedation and analgesia
1.8
14.6
301
1853
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.1
14.5
165
814
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
151.2
14.5
15
*
M25.5
ICD-10 Finland
Pain in joint
1.6
14.4
433
2970
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.2
14.4
158
769
N05AH04
ATC
quetiapine; oral
1.8
14.3
259
1532
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
14.2
518
3734
M48.0
ICD-10 Finland
Spinal stenosis
2.1
14.1
177
912
N05CF01
ATC
zopiclone; oral
1.6
14.1
469
3302
J01MA02
ATC
ciprofloxacin; systemic
1.6
14.0
557
4093
M01AX17
ATC
nimesulide; oral
1.7
13.8
369
2449
J01AA02
ATC
doxycycline; systemic
1.6
13.7
1187
10358
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.6
13.6
102
409
M01AH05
ATC
etoricoxib; oral
1.5
13.5
900
7400
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
13.3
611
4629
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.1
13.2
163
835
H02AB07
ATC
prednisone; oral
1.9
13.2
216
1231
ZXD05
NOMESCO Finland
Urgent procedure
1.6
13.0
439
3089
R08
ICPC
Nose symptom/complaint other
3.5
13.0
60
175
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
12.9
232
1365
AA1AD
NOMESCO Finland
CT of head and brain
1.6
12.8
341
2257
R01AD12
ATC
fluticasone furoate; nasal
1.6
12.8
435
3064
M01AE01
ATC
ibuprofen; systemic, rectal
1.7
12.8
1404
12847
A02BC03
ATC
lansoprazole; oral
1.6
12.5
427
3008
M96.0
ICD-10 Finland
Pseudarthrosis after fusion or arthrodesis
+∞
12.5
12
*
L28
ICPC
Limited function/disability (L)
1.8
12.5
222
1301
7561A
ICD-9 Finland
Other congenital musculoskeletal anomalies, Anomalies of spine[SPONDYLOLISTHESIS CONGENITA]
24.5
12.5
17
7
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
12.4
746
5953
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.2
12.4
133
643
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
12.3
422
2973
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
12.2
248
1514
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.9
12.2
183
1011
S18
ICPC
Laceration/cut
1.5
12.2
595
4541
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.8
12.1
76
277
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
11.9
357
2434
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
2.7
11.7
82
319
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
11.7
393
2754
M03BC01
ATC
orphenadrine (citrate); systemic
1.6
11.7
352
2400
M43.0
ICD-10 Finland
Spondylolysis
4.1
11.6
44
109
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
11.6
303
1988
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
11.5
554
4206
ZXC60
NOMESCO Finland
Application of heat
4.0
11.5
45
115
WX402
NOMESCO Finland
General anaesthesia
1.7
11.5
249
1548
9189
FHL
Other measure in this category
+∞
11.5
11
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.2
11.4
114
532
N06AB10
ATC
escitalopram; oral
1.7
11.4
289
1880
J01FF01
ATC
clindamycin; systemic
1.6
11.4
396
2794
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
11.3
251
1573
8020A
ICD-9 Finland
Fracture of face bones, Nasal bones, closed
15.1
11.3
18
12
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
11.2
140
720
J01DA01
ATC
[U] cefalexin; systemic
1.4
11.2
928
7827
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
11.1
238
1477
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.2
11.1
117
561
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
11.1
302
2004
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
10.9
298
1977
ZXA10
NOMESCO Finland
Bilateral
1.7
10.9
267
1721
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
10.9
172
965
Z3226
NOMESCO Finland
Physiotherapist
1.7
10.9
271
1752
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
4.5
10.9
37
83
A02BA02
ATC
ranitidine; systemic
1.6
10.8
279
1822
WX704
NOMESCO Finland
Intubation
2.2
10.8
112
532
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
3.2
10.8
55
175
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.2
10.8
107
498
N05BA01
ATC
diazepam; systemic, rectal
1.8
10.7
205
1230
L17
ICPC
Foot/toe symptom/complaint
1.6
10.7
347
2406
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
2.7
10.6
74
287
M03BX02
ATC
tizanidine; oral
1.4
10.5
935
7944
7225B
ICD-9 Finland
Intervertebral disk disorders, Degeneration of thoracic or lumbar intervertebral disk[DEGEN DISCI INTERVERT THORAC SEU LUMBOSACR CUM INST]
14.3
10.5
17
12
R06.5
ICD-10 Finland
Mouth breathing
1.9
10.4
150
816
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.2
10.4
110
528
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
10.3
329
2268
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
3.5
10.3
47
138
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.9
10.3
62
222
1220
FHL
Arthroscopy
2.6
10.2
72
282
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.9
10.2
142
765
A01AB09
ATC
miconazole; local oral
2.0
10.0
135
716
R06AE07
ATC
cetirizine; oral
1.4
10.0
624
4950
R02
ICPC
Shortness of breath/dyspnoea
1.8
10.0
166
950
L08
ICPC
Shoulder symptom/complaint
1.6
9.9
273
1810
ZXD20
NOMESCO Finland
Day surgery
1.7
9.9
198
1201
A29
ICPC
General symptom/complaint other
1.9
9.9
153
856
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
2.2
9.9
103
491
9279
FHL
Other measure in this category
12.2
9.8
17
14
R4110
NOMESCO Finland
Physiotherapy
1.5
9.8
375
2693
A02BA04
ATC
nizatidine; systemic
2.1
9.8
114
569
N06AB03
ATC
fluoxetine; oral
1.8
9.8
187
1118
9272
FHL
Metatarsophalangeal joint resection
10.7
9.8
18
17
50499
ICD-8 Finland
Deflected nasal septum
4.0
9.7
37
93
R06AX27
ATC
desloratadine; oral
1.5
9.7
379
2730
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
9.7
281
1888
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
4.6
9.7
32
70
WX320
NOMESCO Finland
Spinalanesthesy
1.6
9.7
306
2100
Z2221
NOMESCO Finland
Medical doctor
1.5
9.7
386
2796
S00.3
ICD-10 Finland
Superficial injury of nose
6.8
9.6
23
34
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
2.7
9.6
65
250
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.2
9.5
98
466
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
3.6
9.4
41
116
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
3.1
9.4
49
159
R53
ICD-10 Finland
Malaise and fatigue
1.6
9.4
277
1869
7228C
ICD-9 Finland
Intervertebral disk disorders, Postlaminectomy syndrome[SYNDROMA LUMBOSACRALE POSTLAMINECTOMIAM]
+∞
9.4
9
*
9273
FHL
Other surgery for toe deformity or pain condition, e.g., Morton, hammer toe
5.4
9.4
27
51
ZXA00
NOMESCO Finland
Right side
1.5
9.3
377
2734
4212
FHL
Maxillapremmaxilla opening septum resection and reconstruction
8.1
9.3
20
25
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.9
9.3
139
767
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.8
9.2
58
212
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.0
9.2
116
598
J01MA12
ATC
levofloxacin; systemic
1.6
9.2
250
1654
R51.80
ICD-10 Finland
Headache
1.7
9.1
202
1260
M20.5
ICD-10 Finland
Other deformities of toe(s) (acquired)
6.7
9.1
22
33
TQW40
NOMESCO Finland
Remowal of suture of skin
2.0
9.1
116
604
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.1
9.0
98
478
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
9.0
121
641
9229
FHL
Other measure in this category
36.9
9.0
11
*
L12
ICPC
Hand/finger symptom/complaint
1.7
9.0
196
1221
SBB10
NOMESCO Finland
Teeth copy
2.1
9.0
95
458
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.1
8.9
97
474
J01FA06
ATC
roxithromycin; oral
1.4
8.8
560
4436
M01AE02
ATC
naproxen; oral, rectal
1.4
8.8
815
6883
W19
ICD-10 Finland
Unspecified fall
1.9
8.7
136
761
R42
ICD-10 Finland
Dizziness and giddiness
1.5
8.7
286
1979
SPAT1153
SPAT
Removal of sutures
1.4
8.7
432
3260
A06AD11
ATC
lactulose; oral
1.7
8.7
188
1168
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
8.3
8.6
18
22
9165
FHL
Removal of osteosynthesis material
3.3
8.6
41
126
M01AH01
ATC
celecoxib; oral (coxibs)
1.6
8.6
249
1671
R03AC03
ATC
terbutaline; inhalant
1.7
8.5
201
1276
R01BA52
ATC
pseudoephedrine, combinations; oral
1.4
8.5
436
3312
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.9
8.5
117
626
NHK99
NOMESCO Finland
Other operation on bone of ankle or foot
4.3
8.5
30
71
UKC02
NOMESCO Finland
Cystoscopy
1.6
8.5
204
1305
L02
ICPC
Back symptom/complaint
1.9
8.5
125
688
S21
ICPC
Skin texture symptom/complaint
1.7
8.5
170
1030
A01
ICPC
Pain general/multiple sites
2.0
8.5
107
556
9193
FHL
Spondylodesis (also includes correction)
90.5
8.4
9
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.2
8.4
86
408
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
8.4
263
1800
7383A
ICD-9 Finland
Other acquired deformity, Acquired deformity of chest and rib
+∞
8.3
8
*
9181
FHL
Anterior spondylodesis
+∞
8.3
8
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
8.3
188
1180
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.4
8.3
65
273
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
8.2
356
2609
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
8.2
454
3491
S01.2
ICD-10 Finland
Open wound of nose
4.3
8.2
29
69
S02.21
ICD-10 Finland
Fracture of nasal bones, open
14.5
8.2
13
9
Z3231
NOMESCO Finland
Registered nurse
1.5
8.2
373
2767
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
2.2
8.1
84
401
N03AE01
ATC
clonazepam; systemic
2.1
8.1
91
450
C07AA05
ATC
propranolol; systemic
1.5
8.1
268
1854
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.0
8.1
100
516
H02AB04
ATC
methylprednisolone; systemic
1.6
8.1
201
1297
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.1
8.1
86
416
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.0
8.1
106
560
J01DA06
ATC
[U] cefuroxime; systemic
1.6
8.0
213
1398
N07BA03
ATC
varenicline; oral
2.1
8.0
86
417
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.9
8.0
119
656
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.5
8.0
62
258
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.2
8.0
76
350
R52.9
ICD-10 Finland
Pain, unspecified
1.9
8.0
124
693
N05CD07
ATC
temazepam; oral
1.7
7.9
162
990
S02.2
ICD-10 Finland
Fracture of nasal bones
13.1
7.9
13
10
Y04.9
ICD-10 Finland
Assault by bodily force by unknown person
4.5
7.9
26
58
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.0
7.8
97
501
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.5
7.7
285
2022
M47.9
ICD-10 Finland
Spondylosis, unspecified
2.7
7.7
51
196
N06AA12
ATC
doxepin; systemic
2.1
7.6
79
379
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
7.6
401
3047
G47.3
ICD-10 Finland
Sleep apnoea
1.5
7.6
308
2226
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
4.2
7.6
27
65
73805
ICD-8 Finland
Other deformities, Digitus malleus
8.1
7.6
16
20
M20.1
ICD-10 Finland
Hallux valgus (acquired)
1.9
7.6
112
618
DJW99
NOMESCO Finland
Other operation on septum of nose
25.1
7.6
10
*
R52.2
ICD-10 Finland
Other chronic pain
2.6
7.5
50
193
M20.4
ICD-10 Finland
Other hammer toe(s) (acquired)
2.3
7.5
64
279
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
2.7
7.5
49
187
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
3.0
7.4
41
141
UDM02
NOMESCO Finland
Sinoscopy
3.0
7.4
41
141
M70.6
ICD-10 Finland
Trochanteric bursitis
1.7
7.4
150
913
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
7.4
265
1869
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
7.3
542
4367
S02.40
ICD-10 Finland
Fracture of malar and maxillary bones, closed
4.4
7.3
25
58
M01AX01
ATC
nabumetone; oral
2.2
7.3
67
305
M95.2
ICD-10 Finland
Other acquired deformity of head
+∞
7.3
7
*
A28
ICPC
Limited function/disability NOS
1.6
7.3
172
1096
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
1.8
7.3
131
771
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
7.3
296
2141
R13
ICD-10 Finland
Dysphagia
2.0
7.3
89
457
A11
ICPC
Chest pain NOS
1.9
7.2
103
559
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
2.9
7.2
42
148
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.6
7.2
51
203
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.7
7.2
147
897
M01CB01
ATC
sodium aurothiomalate; parenteral
3.5
7.2
31
89
M50.3
ICD-10 Finland
Other cervical disc degeneration
2.9
7.2
42
149
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.1
7.2
80
396
7561D
ICD-9 Finland
Other congenital musculoskeletal anomalies, Anomalies of spine[SPONDYLOLYSIS CONGENITA]
30.1
7.1
9
*
M16.1
ICD-10 Finland
Other primary coxarthrosis
1.7
7.1
141
853
M54.2
ICD-10 Finland
Cervicalgia
1.9
7.1
102
557
B18.2
ICD-10 Finland
Chronic viral hepatitis C
4.0
7.1
26
65
ZZH40
NOMESCO Finland
Substitute of bone
5.3
7.1
20
38
A07EC01
ATC
sulfasalazine; oral, rectal
1.8
7.0
118
677
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.4
7.0
347
2605
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.8
7.0
128
755
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
2.0
7.0
89
466
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.9
6.9
99
540
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.9
1034
9235
WZA90
NOMESCO Finland
Other doctors statement
1.4
6.9
306
2245
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.1
6.9
75
367
L84
ICPC
Back syndrome without radiat pain
2.3
6.9
63
286
M01AB55
ATC
diclofenac, combinations; oral
1.9
6.8
96
519
L04AA13
ATC
leflunomide; oral
2.6
6.8
48
190
M01AC06
ATC
meloxicam; systemic, rectal
1.4
6.8
507
4077
XKD00
NOMESCO Finland
Uroflowmetry
1.6
6.8
190
1262
E8859
ICD-8 Finland
Fall on same level from slipping, stumbling or tripping
2.3
6.8
58
255
T74.1
ICD-10 Finland
Physical abuse
3.2
6.8
33
104
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.8
6.8
109
619
A92
ICPC
Allergy/allergic reaction NOS
2.9
6.8
39
136
R03AK07
ATC
formoterol and budesonide; inhalant
1.5
6.8
254
1802
J02AC01
ATC
fluconazole; systemic
1.3
6.8
521
4213
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
6.7
209
1424
R03BB04
ATC
tiotropium bromide; inhalant
1.7
6.7
121
714
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
3.2
6.7
32
100
R03BA02
ATC
budesonide; inhalant
1.5
6.7
234
1639
M54
ICD-10 Finland
Dorsalgia
1.7
6.7
150
939
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
2.1
6.7
70
340
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
6.6
230
1605
M01AH02
ATC
rofecoxib; oral
1.6
6.6
177
1165
7373A
ICD-9 Finland
Curvature of spine, Kyphoscoliosis and scoliosis
12.3
6.6
11
9
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
2.6
6.5
44
172
L88
ICPC
Rheumatoid/seropositive arthritis
2.2
6.5
59
268
R96
ICPC
Asthma
1.8
6.5
114
667
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
2.8
6.5
39
142
L16
ICPC
Ankle symptom/complaint
1.7
6.5
132
805
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.5
6.5
199
1350
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
3.4
6.4
29
87
9807
FHL
Cartilage / perichondrium transfer
70.1
6.4
7
*
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
7.4
6.4
14
19
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
6.4
211
1458
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
2.6
6.4
45
178
J01FA09
ATC
clarithromycin; systemic
1.4
6.4
421
3318
Z01.2
ICD-10 Finland
Dental examination
1.3
6.4
561
4623
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
6.4
582
4820
L15
ICPC
Knee symptom/complaint
1.5
6.4
261
1886
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
6.4
695
5908
SGC00
NOMESCO Finland
Local medication of root channels of tooth
1.6
6.4
144
907
NHG82
NOMESCO Finland
Fusion of other tarsal joint
4.9
6.4
19
39
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.2
6.3
60
280
UJF32
NOMESCO Finland
Coloscopy
1.4
6.3
328
2485
DHB45
NOMESCO Finland
Turbinate reduction
18.1
6.3
9
5
4252
FHL
Resection, coagulation or cryo on the cortex and nasal mucosa
18.1
6.3
9
5
P01BA02
ATC
hydroxychloroquine; oral
1.7
6.3
113
666
N05BA12
ATC
alprazolam; oral
1.7
6.3
138
863
DLD30
NOMESCO Finland
Construction of nose
+∞
6.3
6
*
M95.1
ICD-10 Finland
Cauliflower ear
+∞
6.3
6
*
7388X
ICD-9 Finland
Other acquired deformity, Acquired deformity of other specified site
+∞
6.3
6
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
6.2
404
3171
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
2.7
6.2
38
141
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.0
6.2
73
372
S06.0
ICD-10 Finland
Concussion
1.6
6.2
139
873
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
3.1
6.2
31
101
R01AD05
ATC
budesonide; nasal
1.8
6.2
109
639
R29
ICPC
Respiratory symptom/complaint other
1.9
6.1
81
431
N06AX03
ATC
mianserin; oral
2.1
6.1
65
315
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
6.1
119
720
R4120
NOMESCO Finland
Occupational therapy
1.9
6.1
88
480
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
6.1
795
6909
R03BA01
ATC
beclometasone; inhalant
1.5
6.1
189
1288
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.8
6.1
94
530
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
4.4
6.0
20
46
M06
ICD-10 Finland
Other rheumatoid arthritis
5.2
6.0
17
33
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
2.8
6.0
35
125
B01AB05
ATC
enoxaparin; parenteral
1.4
6.0
383
2999
Mortality – FinRegistry
↥Association
Association between endpoint M13_DEFORMACQ and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DEFORMACQ | 1.497 [1.27, 1.77] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.09 |
During the follow-up period (1.1.1998 — 31.12.2019), 190 out of 2352 females with M13_DEFORMACQ died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DEFORMACQ | 1.264 [1.1, 1.45] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 368 out of 4323 males with M13_DEFORMACQ died.
Mortality risk
Mortality risk for people of age
years, who have M13_DEFORMACQ.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.096% | 0.246% |
| 5 | 0.765% | 1.58% |
| 10 | 1.988% | 3.958% |
| 15 | 3.955% | 7.455% |
| 20 | 7.11% | 12.602% |
Relationships between endpoints
↥Index endpoint: M13_DEFORMACQ – Other acquired deformities of musculoskeletal system and connective tissue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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