hypoparathyroidism: Hypoparathyroidism is is an endocrine disorder in which the parathyroid glands in the neck do not produce enough parathyroid hormone (PTH). Common signs and symptoms includeabdominal pain, brittle nails, cataracts, dry hair and skin,muscle cramps,tetany, pain in the face, legs, and feet, seizures, tingling sensation,and weakened tooth enamel (in children). It may be caused byinjury to the parathyroid glands (e.g., during surgery). Other causes, include low blood magnesium levels, a side effect of radioactive iodine treatment for hyperthyroidism , metabolic alkalosis , DiGeorge syndrome , and type I polyglandular autoimmune syndrome . The goal of treatment is to restore the calcium and mineral balance in the body.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
4 out of 7 registries used, show all original rules. |
1281 |
4. Check minimum number of events
Min. number of events
3
|
1281 |
5. Include endpointsNone |
1281 |
6. Filter based on genotype QC (FinnGen only) |
1281 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Hypoparathyreoidismus
Similar endpoints
↥List of similar endpoints to
Hypoparathyroidism
based on the number of shared cases.
Similar with more cases:
- Disorders of parathyroid gland
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 8240 | 6591 | 1583 |
| Only index persons | 6794 | 5561 | 1233 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.19 | 0.04 |
| Only index persons | 0.18 | 0.20 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 60.83 | 61.53 | 57.93 |
| Only index persons | 60.57 | 61.51 | 56.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1281 | 1016 | 265 |
| Unadjusted period prevalence (%) | 0.30 | 0.35 | 0.12 |
| Median age at first event (years) | 59.38 | 59.35 | 59.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1117
- Matched controls
- 11172
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
106
Kela drug reimbursment
Hypoparathyroidism
+∞
323.0
453
*
H05AA02
ATC
teriparatide; parenteral
4666.4
323.0
473
*
318
Kela drug reimbursment
Teriparatide
2054.5
323.0
475
*
A11CC03
ATC
alfacalcidol; systemic
77.3
321.6
359
68
A12AA04
ATC
calcium carbonate; oral
99.7
288.5
311
43
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
675.8
229.3
219
*
A11CC02
ATC
dihydrotachysterol; oral
600.3
207.0
199
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
7.1
193.6
823
3160
104
Kela drug reimbursment
Thyroid insufficiency
9.7
167.0
382
568
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
37.2
162.8
210
69
M05BX04
ATC
denosumab; parenteral
12.8
161.3
309
325
E83.51
ICD-10 Finland
Hypocalcemia
138.2
147.4
155
13
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
1576.1
145.1
138
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
10.7
144.6
304
377
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
104.2
141.3
153
17
A12AA06
ATC
calcium lactate gluconate; oral
1455.3
135.3
129
*
BAA60
NOMESCO Finland
Total thyroidectomy
19.4
125.8
197
122
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
19.6
122.7
191
116
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
23.8
116.1
169
83
H03AA01
ATC
levothyroxine sodium; systemic
4.5
111.1
554
2019
M05BA04
ATC
alendronic acid; oral
6.7
109.2
316
622
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
36.5
109.2
141
44
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
19.3
108.3
169
102
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
39.9
108.2
137
39
L95
ICPC
Osteoporosis
12.0
99.8
192
190
E20.0
ICD-10 Finland
Idiopathic hypoparathyroidism
1023.6
97.5
94
*
E20.8
ICD-10 Finland
Other hypoparathyroidism
+∞
97.3
92
*
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
182.8
96.9
100
6
M81.9
ICD-10 Finland
Osteoporosis, unspecified
9.0
87.8
199
264
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
5.8
86.3
276
598
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
13.7
76.8
137
113
H02AB09
ATC
hydrocortisone; systemic
20.6
63.0
95
50
M05BA07
ATC
risedronic acid; oral
7.5
60.4
151
228
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.7
51.9
265
870
L04AX01
ATC
azathioprine; systemic
7.1
50.7
130
202
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.6
47.7
148
295
E21.0
ICD-10 Finland
Primary hyperparathyroidism
106.8
47.2
51
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
46.7
607
3598
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
234.2
44.3
45
*
M80.8
ICD-10 Finland
Other osteoporosis with pathological fracture
51.1
41.0
49
10
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.3
39.6
226
792
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
5.4
38.4
121
244
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
38.3
191
603
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
6.9
38.2
99
155
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
37.8
441
2383
N02AX02
ATC
tramadol; systemic, rectal
2.3
37.5
543
3262
N02AA05
ATC
oxycodone; systemic
3.0
36.3
245
959
M80.5
ICD-10 Finland
Idiopathic osteoporosis with pathological fracture
36.8
36.2
46
13
H02AB06
ATC
prednisolone; systemic
2.2
35.9
602
3843
C03CA01
ATC
furosemide; systemic
2.4
35.7
425
2304
E20.1
ICD-10 Finland
Pseudohypoparathyroidism
+∞
35.6
34
*
M05BB03
ATC
alendronic acid and colecalciferol; oral
6.5
35.3
95
157
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
48.4
34.9
42
9
E83.50
ICD-10 Finland
Hypercalcemia
17.5
34.9
55
33
P01BA02
ATC
hydroxychloroquine; oral
3.5
34.8
182
593
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.9
34.7
241
962
M81.4
ICD-10 Finland
Drug-induced osteoporosis
33.4
34.6
45
14
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
34.6
33
*
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
347.3
34.1
34
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.2
33.8
139
369
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.9
33.8
148
416
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
6.3
32.9
90
152
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.0
32.8
139
379
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
10.9
32.5
63
61
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
32.4
31
*
J01FF01
ATC
clindamycin; systemic
2.3
32.0
371
1959
NF1AA
NOMESCO Finland
Hip X-ray examination
3.3
31.5
173
582
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
54.6
31.5
37
7
M05BX03
ATC
strontium ranelate; oral
15.7
31.1
51
34
1930A
ICD-9 Finland
Malignant neoplasm of thyroid gland[CARCINOMA PAPILLARE THYREOIDEAE]
72.0
31.0
35
5
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
4.7
30.7
109
250
L88
ICPC
Rheumatoid/seropositive arthritis
4.8
30.6
106
237
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
30.4
398
2216
J01MA12
ATC
levofloxacin; systemic
2.6
30.2
267
1217
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
29.9
371
2013
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.8
29.5
221
913
E20
ICD-10 Finland
Hypoparathyroidism
+∞
29.3
28
*
M80
ICD-10 Finland
Osteoporosis with pathological fracture
12.6
29.0
52
43
ZX120
NOMESCO Finland
Intravenous
3.2
28.9
163
558
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
6.2
28.1
78
134
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
27.8
161
561
SPAT1262
SPAT
Handing over of treatment supplies
2.5
27.7
266
1261
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
36.1
27.5
35
10
L04AA13
ATC
leflunomide; oral
5.8
27.0
79
145
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
26.7
294
1490
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.9
26.7
77
139
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
26.6
293
1484
M05BA06
ATC
ibandronic acid; systemic
6.0
26.1
74
131
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
26.0
254
1209
N03AX16
ATC
pregabalin; oral
2.2
25.6
326
1767
L04AA01
ATC
[U] ciclosporin; systemic
10.4
25.4
50
50
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.1
25.4
148
517
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
25.2
194
810
L28
ICPC
Limited function/disability (L)
2.4
25.0
252
1219
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.0
24.8
531
3542
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
255.6
24.8
25
*
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
32.9
24.7
32
10
H02AB04
ATC
methylprednisolone; systemic
2.5
24.6
218
986
H02AB07
ATC
prednisone; oral
2.5
24.2
220
1008
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.1
23.9
144
514
L04AA06
ATC
mycophenolic acid; systemic
9.4
23.7
49
54
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
23.7
294
1566
SPAT1254
SPAT
Administration of medicine
2.5
23.7
219
1009
127
Kela drug reimbursment
Transplant complication
12.0
23.6
43
37
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
4.1
23.3
95
249
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
7.0
23.2
58
87
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
22.9
464
3004
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.5
22.8
114
355
2506
FHL
Thyroidectomy
46.0
22.4
27
6
ZXD05
NOMESCO Finland
Urgent procedure
2.0
22.4
380
2295
25219
ICD-8 Finland
Diseases of parathyroid gland, Hypoparathyreoidismus alius sive NUD
+∞
21.9
21
*
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.1
21.9
126
435
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.6
21.7
177
761
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
31.9
21.5
28
9
SPAT1229
SPAT
Assessment of need for aid
2.9
21.5
143
541
N03AX12
ATC
gabapentin; oral
2.3
21.3
216
1038
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
5.2
21.3
67
135
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
21.2
135
499
A28
ICPC
Limited function/disability NOS
2.3
21.1
220
1073
A02BC02
ATC
pantoprazole; systemic
1.9
21.1
759
5934
2521A
ICD-9 Finland
Disorders of parathyroid gland, Hypoparathyroidism
+∞
20.9
20
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
20.3
154
632
M54.5
ICD-10 Finland
Low back pain
1.9
20.3
407
2594
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
20.3
241
1246
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
7.2
20.1
49
71
M81.8
ICD-10 Finland
Other osteoporosis
9.4
20.0
41
45
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
19.8
19
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
+∞
19.8
19
*
AA1AD
NOMESCO Finland
CT of head and brain
2.0
19.8
302
1732
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.3
19.6
199
955
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
25.1
19.6
27
11
M84.3
ICD-10 Finland
Stress fracture, not elsewhere classified
9.8
19.5
39
41
L04AD01
ATC
ciclosporin; systemic
7.0
19.4
48
71
R50.9
ICD-10 Finland
Fever, unspecified
2.4
19.4
176
797
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
19.4
217
1091
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
7.6
19.3
45
61
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
19.3
382
2412
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.4
19.1
95
295
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
19.1
524
3693
A02BC05
ATC
esomeprazole; systemic
1.8
18.8
483
3321
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
18.8
18
*
L03
ICPC
Low back symptom/complaint
2.0
18.8
315
1868
J01MA02
ATC
ciprofloxacin; systemic
1.8
18.7
447
3003
X58
ICD-10 Finland
Exposure to other specified factors
2.4
18.7
174
796
NK6PA
NOMESCO Finland
Measurement of bone density from one location with X-ray
24.2
18.7
26
11
L76
ICPC
Fracture: other
4.6
18.6
65
147
E21.2
ICD-10 Finland
Other hyperparathyroidism
193.1
18.6
19
*
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
18.6
194
941
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
18.4
126
485
NF3AA
NOMESCO Finland
Femur X-ray examination
6.4
18.2
48
78
ZXA10
NOMESCO Finland
Bilateral
2.0
18.1
256
1419
S97
ICPC
Chronic ulcer skin
3.3
17.8
93
299
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
+∞
17.8
17
*
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
5.1
17.6
56
115
SPAT1216
SPAT
Assessment of functional ability
2.1
17.5
218
1145
L17
ICPC
Foot/toe symptom/complaint
1.9
17.4
313
1896
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.8
17.4
396
2603
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
4.3
17.3
65
158
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
17.1
464
3217
UJF32
NOMESCO Finland
Coloscopy
1.9
17.1
321
1972
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
7.5
17.1
40
55
NG4AA
NOMESCO Finland
Lower leg X-ray examination
4.6
17.0
59
133
XG410
NOMESCO Finland
Flow-volume spirometry
3.7
17.0
76
217
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.4
16.9
62
148
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
6.6
16.9
43
67
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
16.8
204
1057
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.7
16.8
57
125
M01CB01
ATC
sodium aurothiomalate; parenteral
5.7
16.8
48
87
B01AB05
ATC
enoxaparin; parenteral
1.8
16.7
381
2496
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.8
16.7
73
204
H26.3
ICD-10 Finland
Drug-induced cataract
11.8
16.6
30
26
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.5
16.5
80
243
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.0
16.5
98
343
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.9
16.4
107
399
A06AD11
ATC
lactulose; oral
2.2
16.4
191
972
E0000UV
ATC
NA
1.7
16.3
467
3281
ND1AA
NOMESCO Finland
Wrist X-ray examination
2.8
16.2
106
397
N02BE01
ATC
paracetamol; systemic, rectal
2.0
16.1
973
8571
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.7
16.1
113
441
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
16.0
186
944
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
16.0
110
426
19399
ICD-8 Finland
Malignant neoplasm of thyroid gland
60.9
15.8
18
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
15.7
231
1289
M05BA01
ATC
etidronic acid; systemic
9.9
15.7
31
32
A07EC01
ATC
sulfasalazine; oral, rectal
2.6
15.7
121
501
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.6
15.7
54
121
SPAT1263
SPAT
Sampling
1.7
15.7
494
3558
E21.1
ICD-10 Finland
Secondary hyperparathyroidism, not elsewhere classified
+∞
15.7
15
*
101
Kela drug reimbursment
Anterior pituitary hypofunction
+∞
15.7
15
*
A07AA02
ATC
nystatin; oral
2.7
15.5
107
416
S52.0
ICD-10 Finland
Fracture of upper end of ulna
6.4
15.4
40
64
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.2
15.3
84
281
J01DB01
ATC
cefalexin; oral
1.8
15.3
904
7790
R13
ICD-10 Finland
Dysphagia
2.9
15.3
96
350
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.8
15.2
317
2005
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.3
15.1
144
663
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
15.0
151
717
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
15.3
14.9
24
16
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
15.3
14.9
24
16
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
14.9
106
418
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
14.9
98
368
Z2446
NOMESCO Finland
Social worker
2.8
14.9
96
358
L04AB01
ATC
etanercept; parenteral
7.3
14.8
35
49
Z94.0
ICD-10 Finland
Kidney transplant status
10.6
14.8
28
27
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.5
14.7
120
510
D64.9
ICD-10 Finland
Anaemia, unspecified
2.4
14.7
132
593
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.7
14.7
102
398
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.1
14.6
80
267
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
14.6
109
443
BBA50
NOMESCO Finland
Total parathyroidectomy
+∞
14.6
14
*
BBA20
NOMESCO Finland
Exploration of parathyroid gland
+∞
14.6
14
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
8.2
14.6
32
40
R53
ICD-10 Finland
Malaise and fatigue
1.9
14.5
251
1488
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
14.5
104
413
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
3.8
14.5
61
166
W19
ICD-10 Finland
Unspecified fall
2.5
14.4
120
518
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
4.7
14.4
49
109
5BA08
NOMESCO Finland
NA
13.6
14.2
24
18
Z3226
NOMESCO Finland
Physiotherapist
1.9
14.2
242
1425
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.9
14.1
39
68
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
14.1
257
1548
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
5.1
14.1
44
89
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.6
14.0
108
446
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
5.3
14.0
42
81
A46
ICD-10 Finland
Erysipelas
2.1
14.0
168
863
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
3.6
14.0
64
187
SPAT1301
SPAT
No procedures
1.7
13.9
377
2575
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.7
13.9
61
172
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.4
13.8
67
205
R03BB04
ATC
tiotropium bromide; inhalant
2.4
13.6
125
567
E31.00
ICD-10 Finland
APECED syndrome
+∞
13.6
13
*
C03DA01
ATC
spironolactone; oral
2.2
13.5
141
681
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.6
13.5
102
418
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.6
13.4
46
103
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
26.1
13.4
18
7
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.7
13.2
385
2674
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
13.1
194
1084
SPAT1255
SPAT
Intravenous administration of medicine
2.7
13.1
93
368
3025
Kela drug reimbursment
Calcium carbonate
28.7
13.0
17
6
K07.60
ICD-10 Finland
Snapping jaw
3.3
12.9
66
210
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
12.9
314
2068
NDG74
NOMESCO Finland
Fusion of first IP joint
22.8
12.9
18
8
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.2
12.9
67
216
M54
ICD-10 Finland
Dorsalgia
2.2
12.9
136
657
S18
ICPC
Laceration/cut
1.6
12.8
471
3472
ZZH31
NOMESCO Finland
Bone allograft, small pieces
7.3
12.8
30
42
R06.0
ICD-10 Finland
Dyspnoea
1.7
12.8
303
1979
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
9.2
12.8
26
29
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.4
12.7
61
185
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
12.7
453
3312
J01MA14
ATC
moxifloxacin; systemic
2.4
12.7
113
503
D35.1
ICD-10 Finland
Benign neoplasm: Parathyroid gland
70.7
12.6
14
*
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.8
12.6
81
300
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
32.4
12.6
16
5
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.8
12.6
52
140
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.2
12.6
134
650
E23.00
ICD-10 Finland
Panhypopituitarism
+∞
12.5
12
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
4.2
12.5
47
116
M48.5
ICD-10 Finland
Collapsed vertebra, not elsewhere classified
20.3
12.5
18
9
E21.5
ICD-10 Finland
Disorder of parathyroid gland, unspecified
131.4
12.5
13
*
TQW40
NOMESCO Finland
Remowal of suture of skin
2.6
12.4
93
379
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.5
12.4
43
98
J46
ICD-10 Finland
Status asthmaticus
3.9
12.4
50
132
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
5.3
12.3
37
72
S82.0
ICD-10 Finland
Fracture of patella
5.3
12.3
37
72
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
12.3
398
2828
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.4
12.3
103
445
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
3.7
12.3
54
153
N06AX21
ATC
duloxetine; oral
2.2
12.3
133
653
S72.3
ICD-10 Finland
Fracture of shaft of femur
7.5
12.2
28
38
M48.0
ICD-10 Finland
Spinal stenosis
2.0
12.2
159
840
C07AB07
ATC
bisoprolol; oral
1.6
12.2
520
3969
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
3.2
12.1
64
209
R11
ICD-10 Finland
Nausea and vomiting
2.4
12.1
105
463
E87.6
ICD-10 Finland
Hypokalaemia
3.5
12.0
55
161
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
12.0
119
560
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
12.0
401
2874
GD1AD
NOMESCO Finland
Thorax CT examination
3.2
12.0
62
200
JN4CD
NOMESCO Finland
Very extensive body CT
3.3
12.0
60
189
M81.5
ICD-10 Finland
Idiopathic osteoporosis
6.9
12.0
29
43
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
11.9
513
3914
A02BA02
ATC
ranitidine; systemic
1.8
11.9
242
1502
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.8
11.9
78
294
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.4
11.9
58
179
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
11.9
136
681
A12BA01
ATC
potassium chloride; oral
2.9
11.8
73
265
NH3EA
NOMESCO Finland
Feet X-ray examination with load
5.0
11.8
37
76
NH1AD
NOMESCO Finland
Ankle and foot CT
5.0
11.8
37
76
H03BB01
ATC
carbimazole; oral
3.0
11.8
67
230
L02
ICPC
Back symptom/complaint
2.3
11.7
113
525
SPAT1231
SPAT
Assessment of adjustments needed in living environment
4.7
11.6
39
86
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.0
11.5
67
234
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.0
11.5
158
855
R03AC02
ATC
salbutamol; inhalant
1.5
11.4
569
4480
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
4.1
11.4
43
107
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.7
11.4
78
301
ZX114
NOMESCO Finland
Intramuscular
5.4
11.2
33
63
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
11.2
396
2865
SPAT1310
SPAT
Counselling related to known health issue
1.6
11.2
363
2571
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
11.2
199
1178
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
2.7
11.2
74
281
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
11.1
246
1564
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
20.3
11.1
16
8
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
11.1
194
1145
Z3231
NOMESCO Finland
Registered nurse
1.7
11.1
312
2124
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.8
11.1
70
259
WX110
NOMESCO Finland
Local anesthesy
1.6
11.1
716
5975
A01AB09
ATC
miconazole; local oral
2.1
11.0
129
654
H02AA02
ATC
fludrocortisone; oral
9.3
11.0
22
24
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.9
11.0
66
236
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.0
11.0
64
224
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.5
11.0
89
379
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
3.8
11.0
45
121
Z3229
NOMESCO Finland
Other healthcare associate professional
2.2
11.0
117
570
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.4
10.9
51
153
ZXE00
NOMESCO Finland
One hour or less
1.6
10.8
433
3220
B01AA03
ATC
warfarin; systemic
1.8
10.8
214
1313
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.7
10.8
73
281
WX204
NOMESCO Finland
Axillary plexus blockaced
3.4
10.8
51
154
L04AB04
ATC
adalimumab; parenteral
4.8
10.8
35
75
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
3.2
10.8
56
182
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
10.8
113
545
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
10.7
126
637
L84
ICD-10 Finland
Corns and callosities
3.5
10.7
49
144
327
Kela drug reimbursment
strontium ranelate
28.3
10.7
14
5
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
6.8
10.7
26
39
EBA10
NOMESCO Finland
Surgical removal of tooth
2.2
10.7
115
561
N06AA09
ATC
amitriptyline; systemic
2.1
10.6
131
677
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
4.1
10.5
40
101
E21.4
ICD-10 Finland
Other specified disorders of parathyroid gland
+∞
10.4
10
*
E23.03
ICD-10 Finland
Lack of ACTH
+∞
10.4
10
*
25298
ICD-8 Finland
Diseases of parathyroid gland, Alii definiti
+∞
10.4
10
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
10.4
218
1361
ZXA00
NOMESCO Finland
Right side
1.6
10.4
320
2228
N18.8
ICD-10 Finland
Other chronic renal failure
4.0
10.4
40
102
T71
ICPC
Malignant neoplasm thyroid
16.2
10.4
16
10
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
10.3
149
820
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
10.3
99
460
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
4.8
10.3
33
70
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
10.7
10.3
19
18
G47.3
ICD-10 Finland
Sleep apnoea
1.8
10.3
198
1202
S72.2
ICD-10 Finland
Subtrochanteric fracture
9.7
10.3
20
21
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.2
10.2
53
172
M54.9
ICD-10 Finland
Dorsalgia, unspecified
2.0
10.1
134
714
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
4.1
10.1
38
95
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
10.1
154
863
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
10.1
522
4104
N05CF01
ATC
zopiclone; oral
1.6
10.1
364
2631
M19.0
ICD-10 Finland
Primary arthrosis of other joints
2.1
10.1
123
632
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
7.3
10.0
23
32
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.3
10.0
92
419
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
4.5
10.0
34
77
J01DA01
ATC
[U] cefalexin; systemic
1.5
9.9
664
5510
H26.4
ICD-10 Finland
After-cataract
2.0
9.9
127
668
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
3.1
9.9
54
182
NAU20
NOMESCO Finland
Removal of internal fixation device from spine or neck
12.3
9.9
17
14
JN4BD
NOMESCO Finland
Extensive body CT
2.0
9.8
130
692
N05CD07
ATC
temazepam; oral
1.9
9.8
152
856
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
9.8
150
843
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.8
9.8
179
1068
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.7
9.8
66
255
R03DA04
ATC
theophylline; systemic, rectal
2.7
9.8
66
255
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
2.5
9.7
73
299
XF640
NOMESCO Finland
NA
3.2
9.7
49
156
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
9.7
172
1015
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
6.2
9.7
25
41
L75
ICPC
Fracture: femur
5.6
9.7
27
49
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
4.5
9.7
33
75
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.4
9.7
45
135
E22.1
ICD-10 Finland
Hyperprolactinaemia
55.5
9.7
11
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.7
9.7
202
1257
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
4.9
9.6
30
62
WW200
NOMESCO Finland
Immunization
3.6
9.6
42
120
J01FA06
ATC
roxithromycin; oral
1.5
9.6
434
3299
P01AB01
ATC
metronidazole; oral, rectal
1.5
9.6
435
3306
R52.2
ICD-10 Finland
Other chronic pain
3.2
9.6
49
158
K02.1
ICD-10 Finland
Caries of dentine
1.5
9.6
550
4403
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
5.5
9.5
27
50
R60.0
ICD-10 Finland
Localized oedema
1.9
9.5
137
752
X57
ICD-10 Finland
Unspecified privation
4.2
9.5
35
86
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.8
9.5
59
215
SXC03
NOMESCO Finland
Other oral or dental procedure
6.7
9.5
23
35
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
7.6
9.4
21
28
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
6.3
9.4
24
39
78892
ICD-8 Finland
Other general symptoms, Hypocalcaemia
+∞
9.4
9
*
2522
FHL
Removal of parathyroidism or multiple parathyroidism (including removal of adenoma or total removal)
+∞
9.4
9
*
E89.1
ICD-10 Finland
Postprocedural hypoinsulinaemia
+∞
9.4
9
*
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
4.0
9.4
36
92
A41.9
ICD-10 Finland
Sepsis, unspecified
3.2
9.3
47
150
XG466
NOMESCO Finland
Sleep oxymetry
3.6
9.3
41
118
SPAT1325
SPAT
Vaccination
1.5
9.3
401
3007
NFJ62
NOMESCO Finland
Internal fixation of fracture of other parts of femur with plate
8.8
9.3
19
22
WX002
NOMESCO Finland
Sedation and analgesia
1.7
9.3
236
1551
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
3.7
9.2
38
104
N05BA01
ATC
diazepam; systemic, rectal
1.9
9.1
150
862
TK800
NOMESCO Finland
Hemodialysis
4.6
9.1
30
66
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.0
9.1
112
577
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
11.6
9.1
16
14
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
9.1
181
1109
WZC30
NOMESCO Finland
Teaching
1.9
9.1
146
835
M87.1
ICD-10 Finland
Osteonecrosis due to drugs
15.7
9.0
14
9
M01AH02
ATC
rofecoxib; oral
1.8
9.0
164
977
S22.3
ICD-10 Finland
Fracture of rib
2.4
8.9
73
311
TNB11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in shoulder joint
7.5
8.9
20
27
D68.9
ICD-10 Finland
Coagulation defect, unspecified
18.8
8.9
13
7
J04AB02
ATC
rifampicin; systemic
5.8
8.9
24
42
M96.6
ICD-10 Finland
Fracture of bone following insertion of orthopaedic implant, joint prosthesis, or bone plate
12.6
8.9
15
12
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.0
8.9
19
24
A02BC01
ATC
omeprazole; systemic
1.6
8.9
308
2194
R4180
NOMESCO Finland
Podiatric therapy
6.9
8.9
21
31
L14
ICPC
Leg/thigh symptom/complaint
2.2
8.9
89
423
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
8.8
233
1549
A01
ICPC
Pain general/multiple sites
2.1
8.8
100
501
X50
ICD-10 Finland
Overexertion and strenuous or repetitive movements
4.2
8.8
32
78
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
3.7
8.8
37
103
G72.9
ICD-10 Finland
Myopathy, unspecified
9.6
8.8
17
18
QCB10
NOMESCO Finland
Major dressing of wound of skin of upper limb
4.0
8.8
34
88
R03AK08
ATC
formoterol and beclometasone; inhalant
2.9
8.8
52
186
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
5.7
8.8
24
43
NA3BA
NOMESCO Finland
Lumbar spine extensive X-ray examination without contrast
14.2
8.7
14
10
A04
ICPC
Weakness/tiredness general
1.8
8.7
158
940
M54.6
ICD-10 Finland
Pain in thoracic spine
2.3
8.6
80
366
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.0
8.6
49
168
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
5.3
8.6
25
48
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.4
8.6
72
313
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.5
8.6
38
110
S32.8
ICD-10 Finland
Fracture of other and unspecified parts of lumbar spine and pelvis
5.5
8.6
24
44
SPAT1153
SPAT
Removal of sutures
1.5
8.6
353
2611
SPAT1210
SPAT
Application of cast or individual aid
2.5
8.6
63
257
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
9.1
8.5
17
19
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
10.1
8.5
16
16
T99
ICPC
Endocr/metab/nutrit disease other
4.6
8.5
28
62
D07AB08
ATC
desonide; topical
1.9
8.5
120
656
NCJ64
NOMESCO Finland
Other internal fixation of fracture of forearm
5.4
8.5
24
45
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
8.5
146
852
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.9
8.4
119
648
M79.6
ICD-10 Finland
Pain in limb
1.5
8.4
390
2959
M40.1
ICD-10 Finland
Other secondary kyphosis
90.7
8.4
9
*
H05BX01
ATC
cinacalcet; oral
90.7
8.4
9
*
NAK40
NOMESCO Finland
Vertebroplasty
90.7
8.4
9
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.5
8.4
62
253
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
7.9
8.4
18
23
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.9
8.4
49
174
J01DA06
ATC
[U] cefuroxime; systemic
1.8
8.4
162
982
K50.9
ICD-10 Finland
Crohn disease, unspecified
5.1
8.4
25
50
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.2
8.3
30
73
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
8.3
550
4484
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
8.3
331
2430
WX202
NOMESCO Finland
Supraclavicular plexus blockade
4.8
8.3
26
55
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.1
8.3
92
458
J45.8
ICD-10 Finland
Mixed asthma
3.0
8.3
47
162
ZZA00
NOMESCO Finland
Split skin graft
3.1
8.2
43
142
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
4.0
8.2
31
79
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.4
8.2
69
302
NDG30
NOMESCO Finland
Fusion of wrist, total
7.6
8.2
18
24
B03XA01
ATC
erythropoietin; parenteral
7.6
8.2
18
24
NDG76
NOMESCO Finland
Fusion of DIP joint
6.1
8.2
21
35
SPAT1234
SPAT
Support of social functional capacity
2.4
8.2
68
293
WX725
NOMESCO Finland
Noninvasive ventilation
2.6
8.2
57
226
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
8.1
635
5333
RS221
NOMESCO Finland
NA
4.7
8.1
26
56
ZXE40
NOMESCO Finland
More than seven and less than nine hours
3.6
8.1
35
100
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
8.2
8.1
17
21
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.2
8.1
83
396
Z49.1
ICD-10 Finland
Extracorporeal dialysis
6.9
8.1
19
28
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
8.1
120
666
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.4
8.1
37
111
Z31.5
ICD-10 Finland
Genetic counselling
2.6
8.1
56
221
71200
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Juvenile rheumatoid arthritis
22.2
8.0
11
5
NFJ60
NOMESCO Finland
Internal fixation of fracture of other parts of femur with intramedullary nail
5.9
8.0
21
36
J01FA01
ATC
erythromycin; systemic
1.8
8.0
142
837
L13
ICPC
Hip symptom/complaint
1.7
7.9
194
1261
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.6
7.9
55
217
NH1BA
NOMESCO Finland
Ankle extensive X-ray examination
3.4
7.9
37
113
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.4
7.9
65
282
Z71.8
ICD-10 Finland
Other specified counselling
1.6
7.9
243
1673
R03AC12
ATC
salmeterol; inhalant
2.6
7.9
55
218
N03AX09
ATC
lamotrigine; oral
2.8
7.9
48
176
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
7.9
236
1617
H25.8
ICD-10 Finland
Other senile cataract
1.8
7.9
136
795
Y88.3
ICD-10 Finland
Sequelae of surgical and medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
7.9
40
130
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
7.9
279
1991
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
2.5
7.9
61
256
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
4.7
7.8
25
54
SPAT1260
SPAT
Consultation of another employee
1.6
7.8
200
1313
NB1AD
NOMESCO Finland
Shoulder CT examination
3.7
7.8
32
88
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.9
7.8
30
78
J01AA02
ATC
doxycycline; systemic
1.5
7.7
832
7406
NDC40
NOMESCO Finland
Secondary prosthetic replacement in of joint of finger or metacarpal
15.1
7.7
12
8
9284
FHL
Wrist ossification surgery
15.1
7.7
12
8
NAG42
NOMESCO Finland
Posterior fusion of cervical spine with or without fixation
15.1
7.7
12
8
RD210
NOMESCO Finland
NA
3.9
7.7
30
79
N03AE01
ATC
clonazepam; systemic
2.3
7.7
69
313
NFU20
NOMESCO Finland
Removal of internal fixation device from femur
4.8
7.7
24
51
-50
ICPC
Medication/prescr/renewal
2.6
7.6
54
216
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
18.5
7.6
11
6
9289
FHL
Other measure in this category
18.5
7.6
11
6
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
11.9
7.6
13
11
M87.9
ICD-10 Finland
Osteonecrosis, unspecified
8.9
7.6
15
17
M13.9
ICD-10 Finland
Arthritis, unspecified
2.2
7.5
79
381
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
3.1
7.5
39
129
A02BC03
ATC
lansoprazole; oral
1.5
7.5
308
2264
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
3.2
7.5
37
118
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.2
7.4
37
119
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.3
7.4
69
317
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
7.4
147
897
ZX108
NOMESCO Finland
Inhalation
7.7
7.4
16
21
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
7.4
175
1124
L01BB01
ATC
NA
13.5
7.4
12
9
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
13.5
7.4
12
9
C08CA02
ATC
felodipine; oral
1.9
7.4
107
589
R06AE07
ATC
cetirizine; oral
1.4
7.4
461
3688
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
7.4
197
1308
JN4AD
NOMESCO Finland
Body CT examination
2.1
7.4
81
402
J02AC01
ATC
fluconazole; systemic
1.4
7.4
446
3544
R03AC03
ATC
terbutaline; inhalant
1.7
7.4
158
990
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
7.3
91
473
7330A
ICD-9 Finland
Other disorders of bone and cartilage, Osteoporosis[OSTEOPOROSIS CENTRALIS]
+∞
7.3
7
*
25200
ICD-8 Finland
Diseases of parathyroid gland, Hyperparathyroidism
+∞
7.3
7
*
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
+∞
7.3
7
*
H01AC01
ATC
somatropin; parenteral
+∞
7.3
7
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
7.3
7
*
M81.1
ICD-10 Finland
Postoophorectomy osteoporosis
+∞
7.3
7
*
K59.1
ICD-10 Finland
Functional diarrhoea
2.3
7.3
66
300
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
7.3
89
461
NHQ40
NOMESCO Finland
Amputation of toe
4.5
7.3
24
54
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
2.2
7.3
75
359
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
7.3
420
3308
NA3SA
NOMESCO Finland
Lumbar spine X-ray examination in standing position
6.3
7.3
18
29
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
7.2
178
1154
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
7.2
272
1961
L99
ICPC
Musculoskeletal disease other
3.3
7.2
34
105
K07
ICPC
Swollen ankles/oedema
2.3
7.2
63
282
UJF92
NOMESCO Finland
Capsular endoscopy
3.6
7.2
30
84
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
4.0
7.2
27
69
S82.1
ICD-10 Finland
Fracture of upper end of tibia
3.9
7.2
28
74
ZZH30
NOMESCO Finland
Bone allograft
30.2
7.2
9
*
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
20.2
7.1
10
5
E83.59
ICD-10 Finland
Other disorders of calcium metabolism
20.2
7.1
10
5
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
2.6
7.1
50
199
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
5.1
7.1
21
42
NG1AD
NOMESCO Finland
Knee CT examination
4.1
7.1
26
65
N18.0
ICD-10 Finland
End-stage renal disease
6.1
7.1
18
30
S92.3
ICD-10 Finland
Fracture of metatarsal bone
2.9
7.1
41
145
S72.4
ICD-10 Finland
Fracture of lower end of femur
5.7
7.1
19
34
C08CA05
ATC
nifedipine; systemic
2.1
7.1
74
359
NH1EA
NOMESCO Finland
Ankle X-ray examination with load or wrench
8.8
7.1
14
16
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.5
7.1
258
1845
WZA00
NOMESCO Finland
Short statement of of health and health related matters
2.2
7.1
67
312
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.3
7.0
59
259
H02AB08
ATC
triamcinolone; systemic
7.0
7.0
16
23
Z01.9
ICD-10 Finland
Special examination, unspecified
2.2
7.0
71
340
A07AA09
ATC
vancomycin; oral
4.5
7.0
23
52
R4120
NOMESCO Finland
Occupational therapy
2.1
7.0
76
377
D68.8
ICD-10 Finland
Other specified coagulation defects
6.4
6.9
17
27
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.8
6.9
111
634
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.1
6.9
36
120
QCB05
NOMESCO Finland
Revision of wound of skin of upper limb
7.6
6.9
15
20
M33.2
ICD-10 Finland
Polymyositis
13.9
6.9
11
8
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.4
6.9
31
93
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
2.5
6.9
49
198
I80.3
ICD-10 Finland
Phlebitis and thrombophlebitis of lower extremities, unspecified
2.5
6.9
49
198
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.6
6.8
46
180
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
6.8
388
3035
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
3.5
6.8
30
88
M01AE02
ATC
naproxen; oral, rectal
1.4
6.8
573
4810
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.0
6.8
87
456
G03XC01
ATC
raloxifene; oral
11.0
6.8
12
11
J45.1
ICD-10 Finland
Nonallergic asthma
2.0
6.8
83
430
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
6.8
296
2200
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
5.3
6.8
19
36
K22.2
ICD-10 Finland
Oesophageal obstruction
5.7
6.8
18
32
A01AB10
ATC
natamycin; local oral
2.7
6.8
44
168
7200A
ICD-9 Finland
Ankylosing spondylitis and other inflammatory spondylopathies, Ankylosing spondylitis
40.3
6.8
8
*
E23.04
ICD-10 Finland
Hypogonadotropic hypogonadism
40.3
6.8
8
*
2754A
ICD-9 Finland
Disorders of mineral metabolism, Disorders of calcium metabolism[HYPERCALCAEMIA]
40.3
6.8
8
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.2
6.8
65
305
N04BC06
ATC
cabergoline; oral (dopamine agonists)
16.8
6.7
10
6
RS222
NOMESCO Finland
NA
4.3
6.7
23
54
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.1
6.7
34
111
N02AC04
ATC
dextropropoxyphene; oral
2.5
6.7
51
213
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
4.1
6.7
24
59
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
2.6
6.7
45
176
NA2AD
NOMESCO Finland
Thoracic spine CT examination
7.2
6.7
15
21
TAB00
NOMESCO Finland
Lumbar puncture
2.6
6.7
47
187
ZZH40
NOMESCO Finland
Substitute of bone
4.9
6.7
20
41
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
4.9
6.7
20
41
K50.1
ICD-10 Finland
Crohn disease of large intestine
4.9
6.7
20
41
N19
ICD-10 Finland
Unspecified kidney failure
2.9
6.7
38
132
Z01.2
ICD-10 Finland
Dental examination
1.4
6.7
404
3198
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
6.6
181
1207
WX882
NOMESCO Finland
High dependency care
2.7
6.6
43
164
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
5.5
6.6
18
33
M02AA10
ATC
ketoprofen; topical
1.6
6.6
175
1160
E000001
ATC
NA
1.5
6.6
206
1422
J01CA04
ATC
amoxicillin; systemic
1.4
6.6
841
7582
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
8.8
6.6
13
15
M35.3
ICD-10 Finland
Polymyalgia rheumatica
2.4
6.5
53
229
S76
ICPC
Skin infection other
2.2
6.5
63
294
TNC11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in elbow joint
10.1
6.5
12
12
M41.9
ICD-10 Finland
Scoliosis, unspecified
4.2
6.5
23
56
J01FA10
ATC
azithromycin; systemic
1.4
6.5
584
4943
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
5.1
6.5
19
38
NC2AA
NOMESCO Finland
Forearm X-ray examination
4.0
6.5
24
61
S32.7
ICD-10 Finland
Multiple fractures of lumbar spine and pelvis
6.2
6.5
16
26
T84.1
ICD-10 Finland
Mechanical complication of internal fixation device of bones of limb
5.7
6.5
17
30
TQW99
NOMESCO Finland
Other minor procedure on skin
2.2
6.4
60
277
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
2.1
6.4
69
338
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.9
6.4
24
62
XF600
NOMESCO Finland
Bloodpressure measurement
2.1
6.4
69
340
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.9
6.4
37
132
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
6.4
221
1560
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
6.6
6.3
15
23
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
6.6
6.3
15
23
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
5.2
6.3
18
35
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
11.1
6.3
11
10
Z94.4
ICD-10 Finland
Liver transplant status
11.1
6.3
11
10
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.3
6.3
29
89
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
9.3
6.3
12
13
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
1.8
6.3
102
586
9527
FHL
Alloarthroplasty, implant or endoprosthesis
18.1
6.3
9
5
347
Kela drug reimbursment
denosumab
18.1
6.3
9
5
SPAT1172
SPAT
Guidance concerning hydration
3.1
6.3
32
106
N06AX11
ATC
mirtazapine; oral
1.4
6.3
326
2501
E31.0
ICD-10 Finland
Autoimmune polyglandular failure
+∞
6.3
6
*
BBA99
NOMESCO Finland
Other operations on parathyroid gland
+∞
6.3
6
*
2581B
ICD-9 Finland
Polyglandular dysfunction and related disorders, Other combinations of endocrine dysfunction[AUTOIMMUNE-POLYENDOCRINOPATHY-CANDIDOSIS-ECTOD DYST]
+∞
6.3
6
*
2520A
ICD-9 Finland
Disorders of parathyroid gland, Hyperparathyroidism
+∞
6.3
6
*
A12AA03
ATC
calcium gluconate; systemic
+∞
6.3
6
*
25810
ICD-8 Finland
Polyglandular dysfunction and other diseases of endocrine glands, Polyglandular dysfunction
+∞
6.3
6
*
8240/3-C25.9
ICD-O-3
Neuroendocrine tumor, NOS, of pancreas, NOS
+∞
6.3
6
*
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
2.8
6.2
38
141
J96.1
ICD-10 Finland
Chronic respiratory failure
3.5
6.2
27
79
D44.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Endocrine gland, unspecified
26.8
6.2
8
*
E21
ICD-10 Finland
Hyperparathyroidism and other disorders of parathyroid gland
26.8
6.2
8
*
P01BA01
ATC
chloroquine; systemic
7.1
6.2
14
20
137
Kela drug reimbursment
Uraemia requiring dialysis
7.1
6.2
14
20
NB6AA
NOMESCO Finland
Humerus X-ray examination
2.9
6.2
34
118
M47.82
ICD-10 Finland
Other spondylosis, cervical region
2.5
6.2
47
194
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.7
6.2
117
705
EBA00
NOMESCO Finland
Extraction of tooth
1.4
6.2
312
2376
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
3.0
6.2
32
107
E000002
ATC
NA
1.7
6.2
118
711
A50
ICPC
General and Unspecified, Medication/prescr/renewal
2.7
6.2
40
152
H11.3
ICD-10 Finland
Conjunctival haemorrhage
2.4
6.2
48
204
TGC00
NOMESCO Finland
Bronchial lavation
3.0
6.2
33
113
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.5
6.2
44
178
NC1BA
NOMESCO Finland
Elbow extensive X-ray examination
5.8
6.2
16
28
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
7.7
6.1
13
17
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.8
6.1
106
624
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
3.9
6.1
23
60
NDG79
NOMESCO Finland
Other excision, reconstruction or fusion of joint of II-V finger
12.6
6.1
10
8
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.1
6.1
31
103
9531
FHL
Arthrodesis of the hand joint
8.6
6.1
12
14
S32.5
ICD-10 Finland
Fracture of pubis
4.4
6.1
20
46
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.4
6.1
381
3023
L60.0
ICD-10 Finland
Ingrowing nail
2.5
6.1
46
191
UJD02
NOMESCO Finland
Gastroscopy
2.2
6.1
58
273
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.5
6.0
208
1464
S72.1
ICD-10 Finland
Pertrochanteric fracture
3.0
6.0
32
109
NCB20
NOMESCO Finland
Primary total prosthetic replacement of elbow joint
10.1
6.0
11
11
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
2.9
6.0
35
125
TNX99
NOMESCO Finland
Other orthopaedic minor procedure
2.7
6.0
39
148
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.9
6.0
89
496
TQW11
NOMESCO Finland
Vacuum treatment of wound
3.3
6.0
28
87
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
4.0
6.0
22
56
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPOPARA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPOPARA | 1.606 [1.43, 1.81] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.323 |
During the follow-up period (1.1.1998 — 31.12.2019), 1113 out of 4177 females with E4_HYPOPARA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPOPARA | 2.355 [1.88, 2.95] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 1066 males with E4_HYPOPARA died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPOPARA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.59% |
| 5 | 1.074% | 2.882% |
| 10 | 2.494% | 7.055% |
| 15 | 4.443% | 13.555% |
| 20 | 7.481% | 22.969% |
Relationships between endpoints
↥Index endpoint: E4_HYPOPARA – Hypoparathyroidism
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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