Divergent concomitant strabismus

H7_DIVERGSTRAB

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H50.1
  • Hospital discharge: ICD-9 3781
  • Hospital discharge: ICD-8 37301
  • Cause of death: ICD-10 H50.1
  • Cause of death: ICD-9 3781
  • Cause of death: ICD-8 37301

2 out of 7 registries used, show all original rules.

3227

4. Check minimum number of events

None

3227

5. Include endpoints

None

3227

6. Filter based on genotype QC (FinnGen only)

3227

Control definitions (FinnGen only)

Control exclude
H7_OCUMUSCLE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H50
Name in latin
Strabismus divergens concomitans

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30557 17266 13194
Only index persons 27598 15794 11804
Unadjusted period prevalence (%)
Whole population 0.44 0.49 0.37
Only index persons 0.53 0.58 0.45
Median age at first event (years)
Whole population 13.93 14.80 12.62
Only index persons 13.95 14.85 12.74

-FinnGen-

Key figures

All Female Male
Number of individuals 3227 2083 1144
Unadjusted period prevalence (%) 0.64 0.71 0.50
Median age at first event (years) 20.81 17.76 26.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2927
Matched controls
29270
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
3503
FHL
Single muscle retroposition
1784.8
323.0
311
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
16378.2
323.0
1067
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
323.0
443
*
H50.31
ICD-10 Finland
Intermittent exotropia
1510.6
323.0
393
*
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
323.0
1533
*
3781B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS DIVERGENS ALTERNANS]
+∞
275.4
260
*
3781A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS CONCOMITANS DIVERGENS]
+∞
233.5
221
*
H50.52
ICD-10 Finland
Exophoria
175.6
218.2
227
14
3507
FHL
Retroposition and resection
+∞
191.8
182
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
1900.8
177.9
171
*
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
+∞
151.4
144
*
H50.2
ICD-10 Finland
Vertical strabismus
1486.8
145.0
140
*
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
132.3
126
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
104.8
100
*
3505
FHL
Single muscle resection
+∞
103.7
99
*
CEC30
NOMESCO Finland
Resection of extraocular muscle
1033.5
102.8
100
*
H53.0
ICD-10 Finland
Amblyopia ex anopsia
32.9
84.0
111
35
3782B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Intermittent heterotropia[STRABISMUS DIVERGENS INTERMITTENS]
+∞
73.2
70
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
69.0
66
*
H53.2
ICD-10 Finland
Diplopia
8.0
64.4
151
197
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
58.5
56
*
H50.30
ICD-10 Finland
Intermittent esotropy
579.1
57.8
57
*
3504
FHL
Retroposition of two muscles
+∞
53.3
51
*
3784B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Heterophoria[EXOPHORIA]
+∞
50.1
48
*
37720
ICD-8 Finland
Other diseases of retina and optic nerve, Amblyopia
78.7
48.1
54
7
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.7
43.6
334
1347
WX140
NOMESCO Finland
Parabulbar anesthesy
4.4
43.5
167
401
H50.9
ICD-10 Finland
Strabismus, unspecified
68.1
41.1
47
7
H51.1
ICD-10 Finland
Convergence insufficiency and excess
+∞
40.7
39
*
H52.0
ICD-10 Finland
Hypermetropia
12.7
36.8
66
53
CEC50
NOMESCO Finland
Advancement of extraocular muscle
+∞
34.4
33
*
37302
ICD-8 Finland
Strabismus, Concomitans sursum sive deorsum vergens
+∞
33.4
32
*
H50.51
ICD-10 Finland
Esophoria
75.0
32.9
37
5
CEC20
NOMESCO Finland
Recession and advancement of extraocular muscle
+∞
32.3
31
*
3781X
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS DIVERGENS ALIUS]
+∞
32.3
31
*
H52.1
ICD-10 Finland
Myopia
6.5
30.5
81
128
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
30.2
459
2536
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.7
29.7
814
5454
3508
FHL
Transposition or anteposition
+∞
28.2
27
*
37001
ICD-8 Finland
Refractive errors, Hypermetropia. Hyperopia
+∞
28.2
27
*
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
20.8
27.8
41
20
XCK00
NOMESCO Finland
Perimetry
2.7
27.4
193
736
H52.2
ICD-10 Finland
Astigmatism
11.5
26.9
50
44
F95
ICPC
Strabismus
273.4
26.8
27
*
H50.8
ICD-10 Finland
Other specified strabismus
136.2
25.6
27
*
3780A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONCOMITANS CONVERGENS]
+∞
24.0
23
*
3783A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Other and unspecified heterotropia
+∞
22.9
22
*
3680A
ICD-9 Finland
Visual disturbances, Amblyopia ex anopsia
+∞
22.9
22
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.7
22.9
159
600
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
231.7
22.6
23
*
37002
ICD-8 Finland
Refractive errors, Myopia
+∞
21.9
21
*
CEC40
NOMESCO Finland
Resection and advancement of extraocular muscle
+∞
21.9
21
*
H50.4
ICD-10 Finland
Other and unspecified heterotropia
+∞
20.9
20
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
20.7
958
7174
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.1
20.5
231
1125
ZXA00
NOMESCO Finland
Right side
1.6
20.0
629
4299
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.1
19.0
229
1143
H27.0
ICD-10 Finland
Aphakia
14.9
17.1
28
19
H50.3
ICD-10 Finland
Intermittent heterotropia
+∞
16.7
16
*
3780B
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONVERGENS ALTERNANS]
+∞
16.7
16
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.0
16.3
205
1044
N05AH03
ATC
olanzapine; systemic
2.1
16.0
179
868
N03AG01
ATC
valproic acid; systemic, rectal
2.1
16.0
183
896
3519
FHL
Other measure in this category
+∞
15.6
15
*
ZXA05
NOMESCO Finland
Left side
1.5
15.2
584
4150
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.8
14.9
96
350
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
9.2
14.7
30
33
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
80.5
14.6
16
*
N03AX09
ATC
lamotrigine; oral
2.2
14.4
148
689
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
42.7
14.1
17
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
42.7
14.1
17
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.0
14.0
194
1027
F20.9
ICD-10 Finland
Schizophrenia, unspecified
3.2
14.0
74
238
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
30.2
13.9
18
6
N05AH04
ATC
quetiapine; oral
1.6
13.8
438
2976
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
34.2
13.5
17
5
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
11.5
13.3
24
21
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
13.2
458
3173
37405
ICD-8 Finland
Cataract, Traumatica
40.2
13.1
16
*
183
Kela drug reimbursment
Lamotrigin and topiramate
4.7
13.0
43
92
N05AH02
ATC
clozapine; systemic
3.0
12.8
73
245
H53.1
ICD-10 Finland
Subjective visual disturbances
2.0
12.1
148
747
N05AA02
ATC
levomepromazine; systemic
2.3
11.8
108
480
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
11.8
374
2533
H53.3
ICD-10 Finland
Other disorders of binocular vision
9.6
11.7
23
24
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.9
11.3
174
956
N05BA01
ATC
diazepam; systemic, rectal
1.6
11.1
309
2029
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
11.0
348
2356
N03AF02
ATC
oxcarbazepine; oral
2.4
11.0
88
367
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
11.9
10.8
19
16
WX002
NOMESCO Finland
Sedation and analgesia
1.5
10.7
431
3073
3501
FHL
Myotomy or tenotomy
+∞
10.4
10
*
H51.8
ICD-10 Finland
Other specified disorders of binocular movement
+∞
10.4
10
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
10.3
310
2068
N03AF01
ATC
carbamazepine; oral, rectal
2.1
10.3
119
586
ZXA10
NOMESCO Finland
Bilateral
1.5
10.3
400
2830
N06AX11
ATC
mirtazapine; oral
1.3
10.3
768
6117
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
13.1
10.1
17
13
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.7
10.1
189
1113
H26.4
ICD-10 Finland
After-cataract
1.9
10.0
140
747
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
4.2
9.9
36
86
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
9.9
627
4860
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
9.9
455
3328
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.7
9.6
200
1212
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
9.4
235
1498
A06AD11
ATC
lactulose; oral
1.6
9.4
261
1709
37000
ICD-8 Finland
Refractive errors, Astigmatismus
+∞
9.4
9
*
3510
FHL
Cardiac surgery on three or more muscles
+∞
9.4
9
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.7
9.4
179
1060
SPAT1101
SPAT
Orthostatic test
2.3
9.3
81
354
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.6
9.2
262
1726
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.9
9.2
53
183
114
Kela drug reimbursment
Glaucoma
1.8
8.9
148
839
H26.02
ICD-10 Finland
Presenil cataract
2.6
8.9
64
253
N03AX14
ATC
levetiracetam; systemic
2.6
8.9
61
236
N05AX12
ATC
aripiprazole; systemic
2.0
8.8
108
549
S01ED01
ATC
timolol; ophthalmic
2.4
8.8
73
311
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
3.1
8.7
46
151
37003
ICD-8 Finland
Refractive errors, Anisometropia
50.1
8.7
10
*
3431A
ICD-9 Finland
Infantile cerebral palsy, Hemiplegic
50.1
8.7
10
*
34301
ICD-8 Finland
Cerebral spastic infantile paralysis, Diplegia spastica
27.6
8.5
11
*
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
90.3
8.4
9
*
N05BA09
ATC
clobazam; oral
4.8
8.4
26
54
3506
FHL
Resection of two muscles
+∞
8.3
8
*
N03AE01
ATC
clonazepam; systemic
1.8
8.3
136
767
N06AB06
ATC
sertraline; oral
1.5
8.3
274
1868
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
2.6
8.3
57
220
N03AX12
ATC
gabapentin; oral
1.5
8.3
342
2446
H54.4
ICD-10 Finland
Blindness, monocular
10.8
8.3
15
14
R62.0
ICD-10 Finland
Delayed milestone
5.8
8.3
22
38
L28
ICPC
Limited function/disability (L)
1.5
8.2
284
1960
CE2W4
NOMESCO Finland
Eye movement mapping
17.2
8.1
12
7
F20.39
ICD-10 Finland
Undifferentiated schizophrenia UNS
4.8
8.1
25
52
N04AA02
ATC
biperiden; systemic
2.6
8.0
56
219
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
8.0
296
2068
Q12.0
ICD-10 Finland
Congenital cataract
22.1
8.0
11
5
N05CF01
ATC
zopiclone; oral
1.3
8.0
693
5609
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.3
7.9
68
296
L17
ICPC
Foot/toe symptom/complaint
1.3
7.9
541
4229
WX704
NOMESCO Finland
Intubation
1.7
7.9
165
1004
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.8
7.8
119
658
P72
ICPC
Schizophrenia
2.7
7.8
50
185
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
7.8
217
1425
K59.09
ICD-10 Finland
Constipation, unspecified
1.9
7.8
116
635
H03AA01
ATC
levothyroxine sodium; systemic
1.3
7.8
528
4122
G40.10
ICD-10 Finland
Simple partial seizures
4.2
7.7
27
64
N05AB03
ATC
perphenazine; systemic, rectal
2.0
7.7
89
446
188
Kela drug reimbursment
Psychosis requiring demanding treatment
3.3
7.6
36
110
F82
ICD-10 Finland
Specific developmental disorder of motor function
6.7
7.6
18
27
S01CA03
ATC
hydrocortisone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.6
7.5
32
90
H52.4
ICD-10 Finland
Presbyopia
2.8
7.4
45
163
G91.1
ICD-10 Finland
Obstructive hydrocephalus
6.5
7.4
18
28
N06AB04
ATC
citalopram; systemic
1.3
7.4
495
3855
N05AD01
ATC
haloperidol; systemic
2.3
7.4
64
281
H05.2
ICD-10 Finland
Exophthalmic conditions
8.4
7.3
15
18
N06AA09
ATC
amitriptyline; systemic
1.5
7.3
211
1398
37929
ICD-8 Finland
Blindness, one eye, specifically defined
+∞
7.3
7
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
7.3
7
*
H50.6
ICD-10 Finland
Mechanical strabismus
+∞
7.3
7
*
H50.39
ICD-10 Finland
Intermittent heterotropia
+∞
7.3
7
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
2.8
7.3
43
153
N03AX11
ATC
topiramate; oral
2.2
7.3
72
338
87011
ICD-8 Finland
Open wound of eye and orbit, Perforans oculi, Complicata
15.8
7.2
11
7
N05AX08
ATC
risperidone; systemic
1.6
7.2
162
1007
SPAT1240
SPAT
Therapeutic discussion
1.5
7.2
269
1886
R03AC02
ATC
salbutamol; inhalant
1.2
7.2
1317
11657
37404
ICD-8 Finland
Cataract, Secundaria
30.1
7.1
9
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
6.6
7.1
17
26
N06AX16
ATC
venlafaxine; oral
1.4
7.1
338
2486
WX702
NOMESCO Finland
Supraglottic ventilation device
1.8
7.0
122
705
A10BA02
ATC
metformin; oral
1.3
6.9
515
4075
H54.7
ICD-10 Finland
Unspecified visual loss
4.8
6.8
21
44
M41.9
ICD-10 Finland
Scoliosis, unspecified
3.1
6.8
35
115
34300
ICD-8 Finland
Cerebral spastic infantile paralysis, Hemiplegia spastica
40.1
6.8
8
*
34408
ICD-8 Finland
Other cerebral paralysis, Alia definita
40.1
6.8
8
*
SPAT1234
SPAT
Support of social functional capacity
1.9
6.7
94
507
37520
ICD-8 Finland
Glaucoma, Secondary
22.6
6.7
9
*
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.5
6.7
189
1250
A46
ICD-10 Finland
Erysipelas
1.4
6.6
263
1872
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.3
6.6
504
4001
N02BE01
ATC
paracetamol; systemic, rectal
1.3
6.6
2237
21072
F20.32
ICD-10 Finland
Undifferentiated schizophrenia stable periodically
8.7
6.5
13
15
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
1.9
6.5
90
482
H54.5
ICD-10 Finland
Severe visual impairment, monocular
5.3
6.5
18
34
H50.50
ICD-10 Finland
Alternating hyperphoria
70.0
6.4
7
*
XA800
NOMESCO Finland
Neuropsychological investigation
1.8
6.3
95
525
M54.4
ICD-10 Finland
Lumbago with sciatica
1.4
6.3
361
2736
WX725
NOMESCO Finland
Noninvasive ventilation
1.8
6.3
100
560
S01EX03
ATC
NA
2.7
6.3
39
145
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.6
6.3
162
1044
3430A
ICD-9 Finland
Infantile cerebral palsy, Diplegic
18.0
6.3
9
5
A28
ICPC
Limited function/disability NOS
1.5
6.3
231
1620
3782A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Intermittent heterotropia[STRABISMUS CONVERGENS INTERMITTENS]
+∞
6.2
6
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
+∞
6.2
6
*
3671A
ICD-9 Finland
Disorders of refraction and accommodation, Myopia
+∞
6.2
6
*
ZSC00
NOMESCO Finland
Procedure related to previous procedure classified in chapter C
+∞
6.2
6
*
78112
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Nystagmus
+∞
6.2
6
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
6.2
692
5764
N03AX16
ATC
pregabalin; oral
1.3
6.2
496
3958
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
6.2
877
7512
F20
ICD-10 Finland
Schizophrenia
3.9
6.2
23
59
WX110
NOMESCO Finland
Local anesthesy
1.2
6.1
1799
16598
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.5
6.1
187
1257
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
12.5
6.1
10
8
XCK10
NOMESCO Finland
Photography of fundus of eye
1.5
6.0
192
1303

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
98
393
2.54
16.19
5.4
5.6
383.6
368.1
umol/l
0.40
87
346
376
2458
1.60
15.01
8.1
8.0
1.6
1.1
mmol/l
1.97
286
1898
337
2182
1.61
13.97
8.4
8.5
95.6
95.9
%
0.54
324
2100
1093
8882
1.35
13.62
3.4
3.2
32.6
34.0
u/l
0.23
1032
8457
318
2043
1.62
13.60
8.5
8.7
123.3
122.6
g/l
0.21
305
1969
368
2449
1.57
13.56
8.2
8.0
5.2
5.1
kpa
1.56
345
2337
368
2450
1.57
13.54
8.2
8.0
12.2
12.8
kpa
1.07
345
2338
887
7012
1.37
13.11
3.2
2.8
—
—
—
0
0
747
5799
1.37
12.25
3.8
3.4
—
—
—
0
0
1377
11786
1.29
11.21
6.6
6.5
1.2
1.2
mmol/l
1.10
1175
10021
704
5495
1.36
11.00
4.5
3.7
1.0
1.0
kg/l
0.04
90
796
876
7067
1.33
10.97
2.2
2.1
208.9
214.0
u/l
0.04
815
6679
857
6910
1.33
10.73
3.5
3.8
7.4
7.4
ph
0.53
135
1319
216
1339
1.66
10.64
8.9
7.0
24.8
24.5
mmol/l
0.52
204
1246
1161
9781
1.29
10.47
3.6
3.2
—
5.8
—
0
6
2142
19498
1.29
10.37
6.8
7.3
78.5
77.0
u/l
0.81
2029
18430
1457
12659
1.28
10.20
3.9
3.4
0.0
0.0
estimate
0.80
237
2352
1453
12682
1.27
9.57
5.1
4.6
0.0
0.0
estimate
0.50
247
2415
1239
10615
1.27
9.52
6.3
5.9
1.2
1.2
mmol/l
0.92
1137
9688
1464
12805
1.26
9.42
3.9
3.4
0.0
0.0
estimate
0.17
242
2341
1629
14428
1.26
9.42
5.1
4.6
6.8
6.6
mmol/l
2.11
1523
13417
216
1383
1.60
9.37
6.2
4.9
—
—
—
0
0
2450
22825
1.30
9.22
17.7
15.1
13.7
13.6
%
1.59
2410
22350
1118
9497
1.27
9.11
1.9
1.9
98.0
96.6
pmol/l
0.43
580
5014
1205
10338
1.26
9.01
4.5
4.8
35.9
36.1
g/l
0.62
1124
9665
2816
26818
1.39
8.81
16.0
13.6
139.7
139.7
mmol/l
0.24
2757
26145
408
3014
1.40
8.79
1.9
1.7
—
—
—
0
0
742
6047
1.29
8.27
4.4
4.2
—
—
—
0
0
1936
17659
1.24
7.98
3.7
3.3
—
—
—
0
0
2817
26919
1.37
7.84
15.9
13.7
4.0
3.9
mmol/l
0.21
2753
26191
2524
23799
1.28
7.43
19.8
15.5
332.5
332.8
g/l
0.94
2507
23639
180
1168
1.57
7.42
9.1
11.1
—
—
—
0
0
139
847
1.67
7.40
5.3
5.2
1.7
1.6
%
0.34
129
786
368
2765
1.37
7.13
8.2
7.4
104.7
104.6
mmol/l
0.20
363
2708
204
1379
1.51
7.01
10.2
10.1
0.7
0.7
%
0.64
204
1368
337
2506
1.38
6.96
2.0
2.1
379.1
371.2
nmol/l
0.32
318
2306
118
700
1.71
6.96
5.9
6.1
1.4
1.3
mmol/l
0.63
103
600
1022
8806
1.23
6.90
3.3
3.2
38.5
48.3
ng/l
0.44
593
5231
2244
20946
1.23
6.82
4.6
4.0
14.7
14.6
pmol/l
1.37
2102
19400
202
1381
1.49
6.59
10.2
10.0
1.6
1.4
%
0.95
202
1372
2088
19402
1.22
6.37
4.2
3.9
11.2
10.9
mm/h
0.46
1965
18153
252
1810
1.43
6.37
2.2
2.3
7.5
7.1
ug/l
0.09
215
1616
133
845
1.60
6.06
5.5
5.3
0.9
0.9
%
0.04
123
786
1469
13242
1.20
6.05
6.6
6.1
0.0
0.0
e9/l
0.06
1284
11535
198
1375
1.47
6.00
10.5
10.2
93.4
94.2
%
1.18
198
1368
109
663
1.67
5.91
6.5
4.1
3.9
3.9
mmol/l
0.67
104
620
1462
13211
1.19
5.76
6.6
6.0
0.6
0.6
e9/l
1.11
1278
11518
545
4456
1.27
5.73
3.6
3.4
381.0
467.8
ng/l
0.24
395
3087
1511
13700
1.19
5.72
7.4
6.3
0.2
0.2
e9/l
0.83
1351
12152
49
233
2.12
5.70
1.3
1.4
11.5
12.3
mmol/l
—
10
54
905
7830
1.22
5.65
2.6
2.5
54.9
57.0
u/l
0.72
832
7276
1660
15201
1.19
5.55
10.6
9.2
4.1
4.0
e9/l
1.32
1456
13350
622
5188
1.25
5.49
1.5
1.5
20.0
20.7
nmol/l
0.66
549
4515
1502
13646
1.19
5.47
6.5
6.1
2.0
2.0
e9/l
0.26
1340
12146
1421
12852
1.19
5.44
5.5
6.1
11.1
11.3
umol/l
0.16
1346
12204
781
6699
1.22
5.27
4.5
3.7
0.0
0.0
estimate
1.49
238
2349
82
478
1.73
5.23
7.1
7.3
11.2
11.3
mmol/l
0.09
73
425
82
479
1.73
5.20
7.1
7.3
104.2
105.5
mmol/l
1.13
73
426
98
602
1.65
5.16
1.8
1.6
1964.5
1246.4
e6/l
0.30
83
484
98
602
1.65
5.16
1.7
1.6
11.4
31.1
e6/l
1.01
78
461
163
1128
1.47
5.07
9.9
10.9
24.5
24.3
mmol/l
0.53
147
1065
20
66
3.04
4.94
2.6
2.2
18.8
16.2
umol/l
0.39
20
66
599
5032
1.23
4.92
2.5
2.5
5.2
6.4
e6/l
1.69
526
4391
2781
26836
1.26
4.91
14.3
12.5
22.4
21.8
mg/l
0.35
2228
20914
1190
10682
1.18
4.79
2.4
2.2
74.2
75.7
nmol/l
1.10
1108
9812
11
25
4.41
4.56
10.9
9.8
—
—
—
0
0
1797
16718
1.17
4.55
4.9
4.0
1821.9
1745.1
e6/l
0.02
34
206
477
3951
1.24
4.44
1.7
1.7
1200.9
1173.4
nmol/l
0.28
385
3051
273
2109
1.32
4.44
4.2
4.1
5.9
5.8
kpa
0.35
266
2049
767
6670
1.20
4.39
1.7
1.6
1.4
1.4
mmol/l
0.07
671
5731
278
2162
1.31
4.32
4.2
4.1
—
7.4
—
0
10
1896
17761
1.16
4.25
4.4
4.0
—
—
—
0
0
461
3823
1.24
4.25
3.2
3.8
0.8
0.8
mmol/l
0.23
436
3603
243
1860
1.33
4.22
1.3
1.3
108.7
204.8
u/ml
4.56
227
1729
381
3095
1.26
4.21
5.4
5.9
1.1
1.1
mmol/l
0.35
361
2889
255
1972
1.32
4.13
7.9
7.8
1.3
1.4
mmol/l
0.42
240
1893
2561
24605
1.20
4.12
5.3
4.7
3.1
2.0
mu/l
0.64
2414
22943
269
2098
1.31
4.10
4.1
4.2
1.9
1.9
mmol/l
0.14
220
1690
93
601
1.56
4.06
1.7
1.4
3.7
3.7
mmol/l
0.10
87
564
249
1926
1.32
4.03
3.6
3.3
—
—
—
0
0
976
8717
1.17
4.03
3.6
3.5
72.1
91.6
e6/l
0.61
695
6020
916
8140
1.17
4.03
2.9
3.3
2.4
2.4
mmol/l
0.01
810
7256
834
7355
1.18
4.02
3.4
3.3
7.4
7.8
mmol/l
1.32
716
6303
550
4671
1.21
4.02
2.5
2.7
543.2
546.0
mosm/kgh2o
0.10
460
3962
1013
9078
1.17
4.01
7.1
8.1
1.1
1.2
inr
1.74
288
2753
225
1721
1.33
3.95
1.5
1.4
—
—
—
0
0
222
1696
1.33
3.93
2.8
2.9
118.6
182.0
ng/l
3.26
197
1522
570
4872
1.21
3.90
1.3
1.3
27.5
28.1
iu/ml
0.03
186
1530
778
6838
1.18
3.89
3.9
4.0
12.6
8.9
mg/mmol
0.63
494
4364
824
7279
1.18
3.88
3.1
3.1
42.6
82.2
e6/l
1.63
648
5535
87
562
1.56
3.82
1.8
1.6
—
—
—
0
0
2468
23680
1.18
3.82
5.7
5.0
39.6
39.0
mmol/mol
2.32
2327
22239
479
4040
1.22
3.75
2.6
2.6
1.0
1.3
e6/l
0.97
276
2247
757
6661
1.18
3.72
3.0
3.0
0.4
0.4
e6/l
0.12
582
4975
225
1746
1.31
3.59
4.2
3.7
5.0
4.7
kpa
0.95
218
1689
122
859
1.44
3.56
6.9
4.8
—
—
—
0
0
244
1920
1.29
3.51
9.2
9.1
—
—
—
0
0
755
6670
1.17
3.51
8.6
6.9
—
—
—
0
0
737
6510
1.17
3.43
3.2
3.3
498.8
389.3
mg/l
0.22
469
4121
1304
12009
1.14
3.42
6.7
6.2
0.7
0.7
%
0.13
1225
11256
89
595
1.51
3.39
4.8
4.4
8.5
8.6
kpa
0.32
84
556
744
6584
1.17
3.38
2.9
2.9
—
—
—
0
0
663
5814
1.18
3.37
3.2
3.0
1042.9
1167.8
ng/l
0.47
558
4868
1341
12384
1.14
3.36
6.7
6.2
2.8
2.8
%
0.04
1260
11593
452
3834
1.21
3.34
1.3
1.4
506.7
540.3
titre
0.14
84
772
106
742
1.44
3.23
1.1
1.3
93.3
130.3
titre
0.36
15
60
963
8715
1.15
3.22
6.4
6.2
—
—
—
0
0
102
710
1.45
3.20
1.4
1.3
—
—
—
0
0
2887
28194
1.23
3.19
13.4
11.5
—
—
—
0
0
1347
12476
1.14
3.18
7.1
6.5
8.4
8.4
%
0.08
1271
11748
25
117
2.15
3.16
4.0
2.2
142.7
157.3
nmol/l
0.42
20
102
250
2004
1.27
3.13
2.5
2.7
10.6
10.5
g/l
0.11
231
1843
353
2941
1.22
3.13
2.6
3.0
9.0
7.6
umol/l
0.34
295
2550
1314
12164
1.14
3.10
3.1
2.8
105.4
106.6
ug/l
0.06
1237
11424
41
231
1.78
3.08
1.2
1.2
38.2
39.7
mg/l
0.10
33
189
1370
12722
1.13
3.07
6.5
6.0
56.9
56.6
%
0.50
1288
11972
40
225
1.79
3.02
1.1
1.1
232.8
266.6
mg/l
0.45
35
193
30
154
1.96
2.99
2.3
1.9
—
—
—
0
0
12
40
3.01
2.97
1.4
1.6
—
—
—
0
0
10
30
3.34
2.90
1.6
1.3
—
—
—
0
0
227
1817
1.27
2.90
3.6
3.3
4.4
4.5
pmol/l
0.64
209
1618
433
3709
1.19
2.89
2.5
2.4
12.9
13.9
umol/l
2.04
406
3449
409
3487
1.20
2.87
2.1
2.0
—
—
—
0
0
177
2256
0.77
2.85
3.6
4.0
—
—
—
0
0
1384
12902
1.13
2.85
6.7
6.2
28.7
28.9
%
0.42
1297
12106
101
725
1.41
2.73
2.0
1.9
4.0
4.3
iu/l
0.11
44
271
33
181
1.83
2.73
1.3
1.2
—
—
—
0
0
12
43
2.80
2.64
1.0
1.2
—
—
—
0
0
12
43
2.80
2.64
1.0
1.2
—
—
—
0
0
12
43
2.80
2.64
1.0
1.2
—
—
—
0
0
561
4953
1.16
2.60
1.7
1.6
77236226.5
32772941.6
pmol/l
0.55
492
4220
127
959
1.34
2.54
3.9
3.3
—
—
—
0
0
967
10489
0.89
2.46
2.7
2.5
—
—
—
0
0
317
2686
1.20
2.41
21.3
20.8
1.2
1.3
inr
0.02
44
401
8
22
3.64
2.36
1.1
1.1
—
—
—
0
0
703
6347
1.14
2.36
4.0
4.0
90.8
92.9
%
1.45
683
6187
150
1174
1.29
2.34
1.1
1.1
1.3
0.9
u/ml
—
6
15
45
283
1.60
2.34
2.3
2.0
—
—
—
0
0
128
982
1.32
2.32
3.7
3.3
0.7
0.7
%
0.19
123
948
155
1221
1.28
2.31
1.4
1.6
358.6
284.5
mu/l
1.52
141
1098
686
6195
1.14
2.29
4.4
4.5
—
—
—
0
0
676
6104
1.14
2.26
2.4
2.2
2.8
2.9
mg/l
0.34
597
5226
3065
30248
1.26
2.25
21.5
18.1
90.4
90.5
fl
1.52
3029
29888
3063
30227
1.26
2.24
21.6
18.2
258.6
257.4
e9/l
0.44
2992
29551
138
1077
1.29
2.22
1.3
1.3
0.3
0.9
u/ml
1.53
11
91
25
135
1.86
2.22
3.8
2.9
146.0
179.9
umol/l
0.25
17
73
3066
30264
1.26
2.21
21.7
18.3
136.0
136.1
g/l
0.21
3029
29895
3065
30254
1.26
2.20
21.6
18.2
4.5
4.5
e12/l
0.75
2987
29518
391
3402
1.17
2.20
2.6
2.4
2.4
2.4
g/l
0.94
361
3170
41
257
1.60
2.18
1.6
1.5
286.5
282.1
mosm/kgh2o
0.58
31
198
363
3143
1.17
2.17
2.6
2.5
21.9
23.8
%
1.86
290
2718
45
289
1.56
2.16
1.8
1.7
—
—
—
0
0
72
510
1.42
2.16
2.7
3.1
32.5
36.5
umol/l
0.65
62
440
3064
30248
1.26
2.16
21.5
18.1
30.1
30.2
pg
1.70
3028
29885
2616
25504
1.14
2.15
16.4
13.2
40.2
40.2
%
0.13
1956
19867
26
144
1.81
2.14
1.1
1.1
—
7.6
nmol/l
—
0
26
3065
30262
1.26
2.13
21.7
18.2
6.8
6.7
e9/l
1.10
2989
29517
520
4634
1.15
2.12
1.4
1.3
2.8
10.0
u/ml
8.67
198
1901
429
3786
1.15
2.01
2.7
2.8
3.9
3.0
e6/l
0.55
222
2011
2592
25283
1.13
2.01
4.5
4.0
5.9
5.8
mmol/l
1.75
2416
23437
191
1571
1.23
2.00
1.6
1.9
1.2
1.4
g/l
1.26
178
1457
348
3030
1.17
1.96
1.5
1.4
—
—
—
0
0
471
4194
1.14
1.95
2.7
2.9
2.4
2.4
mmol/l
0.21
402
3683
237
1999
1.20
1.94
6.6
8.3
8.6
8.8
mmol/l
0.17
222
1920
1958
18838
1.10
1.92
3.3
3.0
47.0
44.2
u/l
0.43
1864
17848
55
382
1.45
1.87
2.7
2.9
—
—
—
0
0
82
612
1.35
1.85
4.4
3.1
—
—
—
0
0
209
1757
1.20
1.79
1.2
1.2
—
—
—
0
0
172
2073
0.82
1.78
1.4
1.4
—
—
—
0
0
19
103
1.85
1.71
1.2
1.1
0.2
1.9
u/ml
1.31
13
57
277
2399
1.17
1.70
2.4
2.4
33.5
59.7
u/l
0.72
227
2070
214
1814
1.19
1.69
1.3
1.4
32.6
28.6
iu/l
0.92
175
1552
707
6509
1.11
1.69
2.3
2.5
1931.8
4243.3
umol/l
1.55
611
5751
2902
28579
1.15
1.68
10.4
9.6
27.8
26.7
u/l
1.45
2824
27751
73
546
1.34
1.66
3.0
3.3
24.8
24.8
mmol/l
0.02
61
486
103
810
1.28
1.64
1.1
1.2
—
—
—
0
0
92
713
1.30
1.64
1.3
1.2
6.2
7.2
u/ml
0.08
11
76
109
864
1.27
1.63
1.4
1.8
1.3
1.2
g/l
2.40
99
814
27
167
1.62
1.58
1.1
1.5
—
—
—
0
0
1238
11739
1.09
1.57
9.8
9.1
0.0
0.0
e9/l
0.18
1006
9601
105
833
1.27
1.57
1.4
1.8
0.2
0.2
g/l
1.04
95
784
43
297
1.45
1.55
1.5
1.6
—
—
—
0
0
43
297
1.45
1.55
1.5
1.6
—
—
—
0
0
43
297
1.45
1.55
1.5
1.6
—
—
—
0
0
43
297
1.45
1.55
1.5
1.6
—
—
—
0
0
66
492
1.35
1.55
4.6
3.6
—
—
—
0
0
12
57
2.11
1.55
1.0
1.0
—
—
—
0
0
145
1196
1.22
1.54
4.0
4.6
24.5
24.1
mmol/l
0.75
129
1091
392
3511
1.13
1.52
1.7
1.6
—
—
—
0
0
177
1493
1.20
1.50
4.2
4.1
5.2
5.2
kpa
0.11
167
1398
131
1073
1.23
1.50
1.3
1.3
204.9
226.0
miu/ml
0.24
47
535
18
101
1.79
1.48
1.8
1.7
—
—
—
0
0
52
376
1.39
1.48
1.3
1.4
63.5
62.7
mmol/l
0.04
38
310
11
52
2.12
1.44
1.4
1.4
—
—
—
0
0
122
997
1.23
1.44
2.2
2.5
20.7
21.3
s
0.81
103
859
104
835
1.25
1.43
1.1
1.1
1.1
4.8
u/ml
2.61
17
122
611
5633
1.10
1.42
1.4
1.5
2.4
2.3
g/l
1.15
371
3532
19
110
1.73
1.42
1.2
1.7
—
—
—
0
0
6
136
0.44
1.40
1.0
1.2
—
—
—
0
0
28
181
1.55
1.40
1.1
1.4
82803.7
84745.3
e6/l
0.01
19
107
7
29
2.42
1.39
1.1
1.2
1.4
1.8
umol/24h
—
7
29
174
1478
1.19
1.39
4.3
4.1
7.4
7.4
ph
0.01
23
178
31
206
1.51
1.37
1.1
1.4
2736.8
2678.6
e6/l
0.02
24
144
28
420
0.66
1.37
1.0
1.1
0.0
0.3
u/ml
—
10
102
5
123
0.41
1.36
2.8
2.8
2150.0
1999.5
ml
—
5
112
695
6462
1.10
1.36
1.3
1.3
1.1
1.6
u/ml
1.11
201
1749
103
833
1.24
1.35
2.8
2.0
1.5
2.0
ug/l
0.36
95
751
641
5943
1.10
1.33
1.8
1.9
1.1
1.1
mg/l
0.12
477
4427
12
61
1.97
1.32
1.2
1.4
52.0
31.3
%
—
5
41
140
1174
1.20
1.30
1.1
1.1
—
—
—
0
0
186
1600
1.17
1.30
1.2
1.2
—
—
—
0
0
89
713
1.26
1.28
3.4
3.1
—
—
—
0
0
8
35
2.29
1.26
1.3
1.8
73.8
104.6
ng/l
—
8
35
202
1755
1.16
1.25
2.9
2.8
71.2
71.2
e9/l
0.01
149
1314
559
6031
0.91
1.22
2.2
2.2
—
—
—
0
0
270
2400
1.14
1.22
2.6
2.8
1.7
1.8
%
0.53
242
2143
390
3547
1.11
1.20
2.1
2.4
29.5
29.7
s
0.30
380
3424
15
86
1.75
1.19
1.8
2.3
—
—
—
0
0
74
587
1.27
1.17
1.6
1.9
190.4
200.6
pmol/l
0.45
68
553
134
1133
1.19
1.17
3.4
3.2
—
—
—
0
0
6
127
0.47
1.16
1.2
1.1
—
—
—
0
0
262
2335
1.13
1.14
1.2
1.2
—
—
—
0
0
66
518
1.28
1.14
4.0
4.1
—
—
—
0
0
19
118
1.61
1.14
2.8
2.6
—
—
—
0
0
8
153
0.52
1.14
1.1
1.4
140.5
131.9
nmol/l
—
8
153
141
1203
1.18
1.12
2.4
2.3
—
—
—
0
0
73
583
1.26
1.11
1.5
1.4
—
—
—
0
0
167
1446
1.16
1.11
1.1
1.1
358.3
120.7
titre
—
6
36
64
505
1.27
1.08
2.1
2.3
135.4
131.4
g/l
0.68
49
376
17
267
0.63
1.07
3.4
3.9
—
—
—
0
0
160
1385
1.16
1.07
1.8
2.3
—
—
—
0
0
36
261
1.38
1.07
1.0
1.1
—
—
—
0
0
129
1098
1.18
1.06
3.3
2.3
—
—
—
0
0
53
409
1.30
1.06
3.5
3.0
7.4
7.3
mmol/l
0.11
53
398
195
1716
1.15
1.05
2.2
2.6
66.3
66.8
g/l
0.34
182
1579
67
535
1.26
1.03
1.5
1.4
21.1
26.2
u/l
0.75
55
440
68
544
1.26
1.03
1.6
1.4
108.6
114.4
u/ml
0.23
26
105
42
553
0.76
1.02
2.2
2.3
0.8
0.8
nmol/l
0.30
36
472
620
6605
0.92
1.02
3.5
3.5
—
—
—
0
0
56
439
1.28
1.01
3.4
2.9
1.6
1.5
mmol/l
0.23
56
424
18
115
1.57
0.99
2.7
3.2
7.4
7.4
ph
—
5
34
758
7171
1.07
0.98
3.3
3.0
—
—
—
0
0
29
206
1.41
0.98
1.1
1.0
—
—
—
0
0
11
186
0.59
0.95
1.0
1.2
—
—
—
0
0
0
32
0.00
0.95
0.0
1.0
—
—
—
0
0
194
1722
1.13
0.94
3.8
3.8
89.0
80.8
ng/l
0.54
174
1513
31
225
1.38
0.94
1.4
1.4
3405.9
98332.6
e6/l
1.41
23
155
6
116
0.52
0.94
1.0
1.2
—
—
—
0
0
73
597
1.23
0.94
1.3
1.3
245.6
260.2
u/ml
0.20
46
369
34
454
0.75
0.93
1.0
1.1
3.8
4.0
u/ml
0.04
19
178
35
465
0.75
0.92
1.8
1.7
—
—
—
0
0
89
744
1.20
0.92
1.2
1.2
—
—
—
0
0
10
55
1.82
0.92
1.0
1.2
—
—
—
0
0
318
3467
0.91
0.90
1.3
1.3
—
—
—
0
0
344
3165
1.10
0.89
1.7
1.8
—
—
—
0
0
20
135
1.48
0.89
1.1
1.0
747.8
754.0
ng/l
0.02
12
88
38
495
0.76
0.88
1.1
1.1
3.5
4.9
u/ml
0.40
19
178
148
1298
1.15
0.87
1.1
1.1
—
—
—
0
0
181
1610
1.13
0.87
3.1
2.7
—
—
—
0
0
70
576
1.22
0.86
1.7
1.8
20146.7
12455.6
e6/l
0.49
52
416
20
136
1.47
0.86
1.1
1.0
282.4
300.1
ng/l
0.12
12
91
23
161
1.43
0.86
1.1
1.1
—
—
—
0
0
94
1105
0.85
0.86
1.5
1.4
—
—
—
0
0
18
120
1.50
0.85
1.8
2.0
2.3
2.8
ug/l
0.15
12
102
61
746
0.81
0.85
1.4
1.5
—
—
—
0
0
203
1823
1.12
0.84
2.4
2.2
12.7
12.7
nmol/l
0.03
183
1617
27
196
1.38
0.84
1.6
2.3
—
—
—
0
0
6
113
0.53
0.83
2.3
2.1
—
—
—
0
0
1027
10673
0.94
0.81
1.9
2.0
—
—
—
0
0
731
7674
0.94
0.80
1.5
1.5
—
—
—
0
0
17
247
0.69
0.79
1.0
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.6
—
—
—
0
0
16
106
1.51
0.78
3.0
2.7
—
—
—
0
0
34
260
1.31
0.78
1.1
1.1
—
—
—
0
0
28
208
1.35
0.77
3.6
1.8
34.5
19.7
ug/l
0.47
28
203
17
115
1.48
0.76
1.9
2.3
—
—
—
0
0
10
161
0.62
0.75
2.2
1.3
—
—
—
0
0
5
24
2.08
0.74
1.0
1.1
—
—
—
0
0
22
301
0.73
0.74
1.1
1.3
—
—
nmol/l
—
0
0
60
722
0.83
0.74
1.4
1.4
—
—
—
0
0
37
289
1.28
0.74
1.5
2.5
—
—
—
0
0
28
211
1.33
0.72
1.7
1.5
—
—
—
0
0
25
185
1.35
0.71
1.9
5.1
12.5
11.5
%
0.56
25
185
49
398
1.23
0.71
1.6
1.5
—
—
—
0
0
60
718
0.83
0.71
1.4
1.4
—
—
—
0
0
31
238
1.31
0.70
2.5
2.5
—
—
—
0
0
378
3537
1.08
0.69
2.1
2.5
107.5
119.6
ug/g
0.30
295
2844
12
77
1.56
0.68
1.4
1.4
—
—
—
0
0
156
1401
1.12
0.68
3.1
2.2
—
—
—
0
0
11
69
1.60
0.68
1.5
1.4
37.2
49.5
%
0.45
11
60
41
329
1.25
0.67
1.3
1.5
—
—
—
0
0
192
2107
0.91
0.67
1.3
1.4
—
—
—
0
0
17
119
1.43
0.66
2.8
2.3
34.8
86.2
ug/l
0.36
17
107
5
93
0.54
0.66
2.4
2.7
—
—
—
0
0
14
94
1.49
0.66
1.0
1.1
—
—
—
0
0
50
412
1.22
0.65
2.5
1.5
—
—
—
0
0
57
477
1.20
0.64
1.1
1.1
—
—
—
0
0
14
201
0.70
0.64
1.0
2.1
—
—
—
0
0
325
3476
0.93
0.64
1.5
1.4
—
—
—
0
0
8
128
0.62
0.64
1.1
1.8
—
7.5
—
0
14
13
189
0.69
0.63
2.0
2.1
0.6
1.7
u/field
—
8
86
1236
12012
1.05
0.63
4.0
3.9
—
—
—
0
0
24
314
0.76
0.63
1.0
1.3
—
—
—
0
0
67
571
1.18
0.62
2.7
2.0
—
—
—
0
0
21
280
0.75
0.62
5.1
4.7
12.9
81.6
u/ml
—
6
80
156
1411
1.11
0.62
3.1
2.2
—
—
—
0
0
23
173
1.33
0.61
1.2
1.5
—
—
—
0
0
14
96
1.46
0.61
1.4
1.4
—
—
—
0
0
55
462
1.19
0.61
2.2
2.8
—
—
—
0
0
766
7962
0.95
0.61
2.3
2.3
—
—
—
0
0
0
20
0.00
0.60
0.0
3.5
—
0.6
—
0
7
0
20
0.00
0.60
0.0
1.0
—
9.1
—
0
7
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
84
733
1.15
0.59
5.9
5.3
1.4
1.4
mg/l
0.15
76
692
0
22
0.00
0.59
0.0
1.5
—
344.1
—
0
22
156
1416
1.11
0.59
3.2
2.2
—
—
—
0
0
6
35
1.72
0.57
5.3
2.7
—
—
—
0
0
17
230
0.74
0.57
3.6
2.9
—
—
—
0
0
81
710
1.14
0.55
2.5
2.2
9.5
11.4
mg/l
1.26
76
659
509
4857
1.06
0.54
1.6
1.6
—
—
—
0
0
19
142
1.34
0.54
1.1
1.1
1810.3
1565.6
miu/ml
0.35
19
142
26
204
1.28
0.54
1.1
1.2
—
65.8
—
0
12
205
1896
1.09
0.54
2.4
3.6
1.2
1.2
mmol/l
0.38
175
1648
617
5923
1.05
0.53
4.4
4.3
2.7
2.3
ug/l
0.51
552
5345
104
930
1.12
0.53
1.6
1.9
1.5
1.5
g/l
0.09
91
818
27
214
1.26
0.52
1.5
1.4
1.3
1.4
nmol/l
0.17
21
192
143
1303
1.10
0.52
3.3
2.3
—
—
—
0
0
177
1920
0.92
0.52
2.5
2.7
4.0
4.1
e9/l
0.08
146
1567
15
109
1.38
0.51
1.2
1.0
—
—
—
0
0
244
2281
1.08
0.50
2.2
2.4
0.2
0.2
g/l
0.12
232
2145
229
2143
1.07
0.47
4.1
4.5
1.0
0.9
%
0.31
50
585
80
712
1.13
0.46
1.8
2.6
—
—
—
0
0
210
1961
1.08
0.46
3.6
4.2
0.9
0.6
%
0.89
36
445
124
1133
1.10
0.45
2.5
1.8
—
—
—
0
0
150
1385
1.09
0.44
3.2
2.2
—
—
—
0
0
26
211
1.23
0.43
1.3
1.1
—
—
—
0
0
22
274
0.80
0.43
1.0
1.2
—
—
—
0
0
114
1040
1.10
0.43
1.8
1.6
47.7
9.6
u/ml
—
5
32
5
31
1.61
0.43
1.0
1.1
—
—
—
0
0
13
173
0.75
0.42
7.1
6.7
—
—
—
0
0
0
15
0.00
0.41
0.0
3.4
—
—
—
0
0
0
16
0.00
0.41
0.0
2.0
—
177.3
—
0
16
16
123
1.30
0.40
2.4
2.0
1.7
1.9
umol/l
0.36
16
115
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
16
205
0.78
0.40
1.6
1.5
—
—
—
0
0
20
159
1.26
0.40
1.1
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
33
278
1.19
0.40
1.5
1.7
52.3
60.5
%
0.58
22
173
53
465
1.14
0.39
1.1
1.1
1.2
2.8
u/ml
2.38
27
233
84
759
1.11
0.39
1.8
2.5
2864.1
390.6
ug/l
0.50
75
707
100
912
1.10
0.39
1.4
1.4
13.2
10.1
u/l
0.95
77
738
55
484
1.14
0.39
1.1
1.1
—
—
—
0
0
54
475
1.14
0.39
2.1
2.5
16.9
16.6
%
0.26
32
238
17
215
0.79
0.39
2.6
3.1
67.8
55.4
%
—
8
152
241
2279
1.06
0.39
1.4
1.5
—
—
—
0
0
46
527
0.87
0.38
1.1
1.1
—
—
—
0
0
56
631
0.89
0.37
1.2
1.3
—
—
—
0
0
13
98
1.33
0.37
1.1
1.3
—
—
—
0
0
8
115
0.69
0.37
1.4
1.6
—
—
—
0
0
10
72
1.39
0.37
1.5
1.5
10.8
12.5
g/l
—
5
55
26
216
1.21
0.36
2.8
3.2
311.5
43.7
mg/l
0.50
13
159
45
393
1.15
0.36
1.3
1.5
—
—
—
0
0
46
524
0.88
0.36
1.1
1.1
—
—
—
0
0
29
342
0.85
0.35
1.1
1.3
—
0.4
nmol/l
—
0
24
5
80
0.62
0.35
1.2
1.1
—
—
—
0
0
30
352
0.85
0.35
1.9
3.5
1.3
1.4
%
0.08
20
292
40
458
0.87
0.34
1.6
1.7
0.5
0.8
g/l
2.76
32
346
47
414
1.14
0.34
2.4
2.6
5.0
5.8
umol/l
0.39
36
305
187
1763
1.06
0.34
1.3
1.3
38.6
48.0
au/ml
—
6
77
17
211
0.80
0.34
1.1
1.1
1.2
1.5
u/ml
—
8
60
68
614
1.11
0.34
1.9
2.2
39.2
38.0
g/l
1.18
60
535
177
1878
0.94
0.34
1.8
1.7
—
—
—
0
0
6
45
1.33
0.33
1.0
1.4
—
—
—
0
0
50
444
1.13
0.33
1.3
1.3
3.7
5.1
u/ml
0.53
24
192
6
47
1.28
0.32
1.7
1.4
—
—
—
0
0
69
627
1.10
0.31
1.1
1.1
3.2
5.6
u/ml
1.12
43
332
68
618
1.10
0.31
1.3
1.2
—
—
—
0
0
7
54
1.30
0.30
2.4
2.5
—
—
—
0
0
57
514
1.11
0.30
3.5
3.4
27.5
24.0
mg/l
0.22
36
324
2606
26222
0.97
0.30
4.3
4.0
1.4
1.5
mmol/l
4.65
2456
24620
148
1393
1.07
0.30
2.5
2.2
1416.8
5151.8
u/l
3.04
51
548
106
986
1.08
0.30
1.3
1.3
—
—
—
0
0
24
203
1.18
0.29
1.8
1.5
37.9
33.9
%
0.20
19
119
202
1922
1.05
0.29
2.4
2.4
17.8
21.5
au/ml
0.33
14
140
31
269
1.15
0.29
1.7
2.6
—
—
—
0
0
118
1104
1.07
0.29
4.9
4.2
—
—
—
0
0
8
108
0.74
0.29
1.6
1.3
—
—
—
0
0
75
689
1.09
0.28
1.1
1.1
1.1
1.9
u/ml
0.67
35
281
112
1047
1.07
0.28
1.2
1.2
—
—
—
0
0
53
479
1.11
0.28
2.5
3.9
—
—
—
0
0
261
2719
0.96
0.27
1.4
1.4
—
—
—
0
0
24
205
1.17
0.27
1.0
1.1
373.6
391.2
nmol/l
0.14
17
190
26
224
1.16
0.27
4.0
2.2
15.2
12.1
%
0.56
19
111
42
467
0.90
0.25
1.3
1.2
—
—
—
0
0
202
1934
1.05
0.24
4.3
4.6
0.0
0.4
%
0.94
36
464
53
580
0.91
0.24
1.1
1.1
2.0
2.3
u/ml
0.05
12
144
32
284
1.13
0.23
3.5
2.5
1.3
1.3
e9/l
0.00
22
168
5
38
1.32
0.23
1.0
1.3
—
8.4
—
0
14
99
1052
0.94
0.23
1.7
1.7
—
—
—
0
0
49
448
1.10
0.22
1.2
1.2
—
—
—
0
0
29
257
1.13
0.22
4.3
4.2
6.4
7.1
mmol/l
0.88
19
221
5
41
1.22
0.22
1.0
1.3
—
—
—
0
0
88
826
1.07
0.22
2.7
3.8
0.3
0.3
g/l
0.01
43
374
48
439
1.09
0.22
1.6
3.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
13
156
0.83
0.21
6.6
3.4
—
—
—
0
0
0
12
0.00
0.21
0.0
5.1
—
388.2
—
0
12
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
39
354
1.10
0.20
2.8
3.2
0.8
0.8
nmol/l
0.03
34
277
22
192
1.15
0.20
1.1
1.1
—
—
—
0
0
33
297
1.11
0.20
2.2
2.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
69.9
—
0
9
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
21
183
1.15
0.20
1.1
1.2
1.1
1.0
ratio
—
6
70
12
99
1.21
0.19
1.2
1.2
—
0.1
—
0
7
339
3481
0.97
0.19
2.8
2.8
0.8
0.7
ug/l
0.47
214
2086
64
599
1.07
0.18
1.1
1.1
0.3
1.3
u/ml
2.01
30
264
24
269
0.89
0.18
1.0
1.4
—
—
—
0
0
104
990
1.05
0.18
5.3
4.3
24.8
24.8
mmol/l
0.09
98
928
10
121
0.83
0.18
1.1
1.6
—
—
—
0
0
7
61
1.15
0.17
1.4
1.1
—
—
—
0
0
18
205
0.88
0.17
1.1
1.3
—
—
—
0
0
2627
26370
0.98
0.17
4.4
4.0
4.7
4.8
mmol/l
3.41
2484
24879
317
3248
0.97
0.16
1.2
1.2
—
—
—
0
0
8
68
1.18
0.16
1.9
2.2
—
—
—
0
0
20
225
0.89
0.16
1.1
1.0
—
—
—
0
0
6
78
0.77
0.15
3.0
3.1
—
—
—
0
0
2520
25298
0.98
0.15
3.9
3.6
1.3
1.3
mmol/l
1.30
2369
23650
9
81
1.11
0.15
1.0
1.1
—
—
—
0
0
43
460
0.93
0.14
1.0
1.1
3.7
18035.6
iu/ml
—
6
130
44
412
1.07
0.13
1.3
1.7
—
—
—
0
0
75
785
0.95
0.13
2.4
3.7
248.3
1931.5
u/ml
0.72
63
672
284
2781
1.02
0.13
1.3
1.3
—
—
—
0
0
586
5939
0.98
0.12
2.0
1.9
—
—
—
0
0
12
104
1.15
0.12
2.2
1.5
14.8
14.9
pmol/l
0.01
12
87
22
200
1.10
0.12
1.3
2.0
8.1
6.6
mmol/l
0.68
15
139
10
85
1.18
0.12
1.5
1.7
—
—
—
0
0
20
181
1.11
0.12
1.2
1.3
32.8
32.9
nmol/l
0.01
14
156
41
436
0.94
0.12
1.5
1.6
—
—
—
0
0
35
327
1.07
0.11
1.1
1.3
—
—
—
0
0
87
837
1.04
0.11
9.5
8.4
—
—
—
0
0
223
2182
1.02
0.11
4.3
3.7
—
—
—
0
0
24
221
1.09
0.11
1.2
1.2
0.0
0.5
u/ml
—
10
86
24
221
1.09
0.11
3.9
2.7
998.3
753.7
e6/l
—
7
85
42
444
0.95
0.10
1.6
1.8
—
—
—
0
0
5
46
1.09
0.09
1.2
2.0
—
—
—
0
0
340
3450
0.98
0.09
1.2
1.2
—
—
—
0
0
5
47
1.06
0.09
1.0
1.3
3.1
3.6
mmol/l
—
5
42
53
507
1.05
0.09
1.3
1.1
—
13.2
—
0
37
11
124
0.89
0.09
1.9
2.0
—
—
—
0
0
31
329
0.94
0.09
1.1
1.2
—
—
—
0
0
218
2142
1.02
0.08
1.2
1.2
122.3
156.5
iu/ml
0.71
84
819
17
185
0.92
0.08
1.4
1.6
—
—
—
0
0
24
224
1.07
0.08
1.1
1.3
—
62.9
—
0
7
208
2045
1.02
0.08
4.3
4.5
0.2
0.1
%
0.32
45
541
7
67
1.04
0.08
1.4
1.5
65.9
60.0
%
—
7
54
6
74
0.81
0.07
1.8
2.1
—
196.9
—
0
9
60
579
1.04
0.07
1.2
1.4
—
—
—
0
0
8
74
1.08
0.07
2.0
1.5
—
—
—
0
0
34
323
1.05
0.07
1.1
1.2
—
—
—
0
0
8
75
1.07
0.07
1.8
1.6
—
—
—
0
0
8
77
1.04
0.07
8.4
10.8
—
—
—
0
0
42
402
1.05
0.07
1.2
1.2
—
—
—
0
0
30
284
1.06
0.07
1.7
1.4
6.5
6.8
g/l
0.12
23
195
7
82
0.85
0.07
1.3
1.2
—
—
—
0
0
9
87
1.03
0.07
1.6
1.3
—
—
—
0
0
8
92
0.87
0.06
1.1
1.7
—
—
—
0
0
36
344
1.05
0.06
2.1
2.5
—
—
—
0
0
30
285
1.05
0.06
1.7
1.4
—
—
—
0
0
218
2211
0.98
0.06
2.9
4.1
8.8
20.0
ug/l
1.33
156
1755
67
690
0.97
0.06
1.4
1.4
265.1
300.7
ug/g
0.60
37
377
9
100
0.90
0.06
1.0
1.0
—
—
—
0
0
9
100
0.90
0.06
1.1
1.1
—
—
—
0
0
9
102
0.88
0.06
1.3
1.7
—
—
—
0
0
9
104
0.87
0.06
1.2
1.4
—
—
—
0
0
57
588
0.97
0.06
1.9
3.5
39.7
46.0
mg/l
0.18
44
478
30
286
1.05
0.06
1.1
1.4
759.3
352.2
pmol/l
0.63
19
226
11
121
0.91
0.06
1.2
1.0
—
—
—
0
0
14
129
1.09
0.05
1.1
1.1
139.1
193.5
iu/ml
0.79
14
129
57
587
0.97
0.05
1.9
3.5
39.2
65.9
mg/l
1.19
43
476
18
191
0.94
0.04
2.1
2.5
690.9
626.8
ml
0.23
11
132
38
367
1.04
0.04
1.3
1.8
—
—
—
0
0
21
199
1.06
0.04
1.0
1.1
18.5
10.9
iu/ml
—
7
52
54
526
1.03
0.04
5.2
3.9
3.0
2.5
mmol/l
0.48
40
341
2672
26691
1.01
0.04
4.8
4.4
2.8
2.9
mmol/l
1.76
2514
25016
18
170
1.06
0.04
4.0
2.8
40.2
42.4
%
—
5
47
20
210
0.95
0.03
2.9
3.5
16.1
25.0
mu/l
1.66
20
203
51
498
1.02
0.03
1.1
1.2
—
—
—
0
0
62
632
0.98
0.03
4.9
3.7
7.4
7.4
ph
0.14
52
517
65
661
0.98
0.02
1.1
1.1
—
—
—
0
0
52
510
1.02
0.02
3.0
3.6
58.1
57.3
%
0.19
52
510
15
158
0.95
0.02
1.5
1.5
16.7
24.6
umol/l
0.76
15
150
328
3264
1.01
0.02
1.8
1.7
—
—
—
0
0
55
541
1.02
0.02
1.3
1.5
0.6
0.4
nmol/l
0.33
38
425
42
428
0.98
0.01
2.0
1.6
—
—
—
0
0
22
213
1.03
0.01
1.0
1.2
—
—
—
0
0
24
233
1.03
0.01
4.8
3.3
—
—
—
0
0
29
283
1.02
0.01
1.7
1.4
0.4
0.4
g/l
0.24
22
193
29
283
1.02
0.01
1.7
1.4
3.0
2.9
g/l
0.10
22
194
11
104
1.06
0.01
2.2
2.6
—
—
—
0
0
43
424
1.01
0.00
1.3
1.4
2.3
4.2
ug/l
1.76
34
380
20
199
1.01
0.00
1.1
1.1
—
—
—
0
0
19
186
1.02
0.00
1.4
1.2
—
—
—
0
0
11
108
1.02
0.00
1.1
1.1
—
—
—
0
0
54
536
1.01
0.00
2.2
2.6
80.1
98.7
ug/min
0.23
33
330
19
188
1.01
0.00
1.0
1.0
—
—
—
0
0
21
208
1.01
0.00
1.0
1.1
8.2
2.6
u/ml
0.31
11
72
0
5
0.00
0.00
0.0
1.6
—
2923.3
—
0
5
0
6
0.00
0.00
0.0
1.2
—
39.8
—
0
6
0
8
0.00
0.00
0.0
2.8
—
4.3
—
0
8
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
0.00
3.6
4.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
65
0.92
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
2.6
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
65.4
—
0
5
0
7
0.00
0.00
0.0
1.1
—
119.3
—
0
7
20
200
1.00
0.00
1.1
1.2
—
—
—
0
0
8
88
0.91
0.00
2.1
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
1.8
—
0
5
0
9
0.00
0.00
0.0
1.4
—
310.5
—
0
9
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_DIVERGSTRAB and mortality.

Females

Parameter HR [95% CI] p-value
H7_DIVERGSTRAB 1.402 [1.2, 1.63] < 0.001
Birth year 0.994 [0.99, 1.0] 0.189

During the follow-up period (1.1.1998 — 31.12.2019), 367 out of 5205 females with H7_DIVERGSTRAB died.

Males

Parameter HR [95% CI] p-value
H7_DIVERGSTRAB 1.47 [1.26, 1.71] < 0.001
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 424 out of 4879 males with H7_DIVERGSTRAB died.

Mortality risk

Mortality risk for people of age

years, who have H7_DIVERGSTRAB.

N-year risk Females Males
1 0.126% 0.247%
5 0.883% 1.752%
10 1.992% 4.215%
15 3.76% 8.247%
20 6.617% 14.032%

Relationships between endpoints

Index endpoint: H7_DIVERGSTRAB – Divergent concomitant strabismus

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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