Risteys · H7_HETEROPHORIA

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H50.50, H50.51, H50.52, H50.59 Hospital discharge: ICD-9 — 3784 Hospital discharge: ICD-8 — 37303 Cause of death: ICD-10 — H50.50, H50.51, H50.52, H50.59 Cause of death: ICD-9 — 3784 Cause of death: ICD-8 — 37303 2 out of 7 registries used, show all original rules.	3336
4. Check minimum number of events None	3336
5. Include endpoints None	3336
6. Filter based on genotype QC (FinnGen only)	3336

	All	Female	Male
Number of individuals
Whole population	35719	21245	14411
Only index persons	30356	18385	11971
Unadjusted period prevalence (%)
Whole population	0.52	0.61	0.40
Only index persons	0.59	0.68	0.46
Median age at first event (years)
Whole population	10.72	12.19	8.41
Only index persons	13.00	14.96	10.00

	All	Female	Male
Number of individuals	3336	2362	974
Unadjusted period prevalence (%)	0.70	0.81	0.43
Median age at first event (years)	29.79	27.66	34.95

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
2958: Matched controls
29581

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

37303

ICD-8 Finland

Strabismus, Heterophoria (exophoria, esophroria, hypophoria)

+∞

323.0

672

H50.51

ICD-10 Finland

Esophoria

1996.8

323.0

486

H50.52

ICD-10 Finland

Exophoria

2593.3

323.0

1581

H50.31

ICD-10 Finland

Intermittent exotropia

1446.7

323.0

379

CEC10

NOMESCO Finland

Recession and resection of extraocular muscle

+∞

263.5

249

H53.2

ICD-10 Finland

Diplopia

20.8

242.4

370

202

H50.1

ICD-10 Finland

Divergent concomitant strabismus

1076.4

207.8

201

3503

FHL

Single muscle retroposition

+∞

200.3

190

37301

ICD-8 Finland

Strabismus, Concomitans divergens

+∞

197.1

187

3784B

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Heterophoria[EXOPHORIA]

+∞

172.6

164

CEC00

NOMESCO Finland

Recession of extraocular muscle

+∞

141.8

135

H50.0

ICD-10 Finland

Convergent concomitant strabismus

683.2

133.7

131

H50.2

ICD-10 Finland

Vertical strabismus

+∞

133.3

127

XCW99

NOMESCO Finland

Other investigative procedure of eye

4.7

129.8

493

1213

H50.30

ICD-10 Finland

Intermittent esotropy

601.4

117.9

116

H52.1

ICD-10 Finland

Myopia

11.8

92.0

175

157

H51.1

ICD-10 Finland

Convergence insufficiency and excess

873.4

87.1

H52.0

ICD-10 Finland

Hypermetropia

30.1

85.8

116

Z01.0

ICD-10 Finland

Examination of eyes and vision

2.9

83.4

608

2455

H50.59

ICD-10 Finland

Heterophor UNS

271.1

77.9

H50.50

ICD-10 Finland

Alternating hyperphoria

205.4

77.6

3505

FHL

Single muscle resection

+∞

65.9

H52.2

ICD-10 Finland

Astigmatism

26.8

65.5

3782B

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Intermittent heterotropia[STRABISMUS DIVERGENS INTERMITTENS]

+∞

61.7

3507

FHL

Retroposition and resection

314.0

60.6

CEC30

NOMESCO Finland

Resection of extraocular muscle

+∞

56.4

37300

ICD-8 Finland

Strabismus, Concomitans convergens

+∞

51.2

H53.1

ICD-10 Finland

Subjective visual disturbances

3.5

49.1

245

742

H49.1

ICD-10 Finland

Fourth [trochlear] nerve palsy

238.7

46.1

H50.9

ICD-10 Finland

Strabismus, unspecified

75.7

46.1

AA1AD

NOMESCO Finland

CT of head and brain

2.1

44.8

604

3229

H53.3

ICD-10 Finland

Other disorders of binocular vision

28.3

44.8

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.8

43.5

1046

6911

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

2.8

42.7

294

1113

3781B

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS DIVERGENS ALTERNANS]

+∞

39.7

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

2.7

39.6

292

1152

H49.2

ICD-10 Finland

Sixth [abducent] nerve palsy

+∞

34.4

N03AX16

ATC

pregabalin; oral

1.9

32.5

602

3582

H53.0

ICD-10 Finland

Amblyopia ex anopsia

10.7

32.4

R51.80

ICD-10 Finland

Headache

1.9

32.3

505

2826

XCK00

NOMESCO Finland

Perimetry

3.0

31.7

190

655

R03AC02

ATC

salbutamol; inhalant

1.6

31.7

1521

11853

AA1BG

NOMESCO Finland

Standard MRI examination of brain with high intensity magnet

2.4

31.5

284

1245

H50.8

ICD-10 Finland

Other specified strabismus

161.7

30.7

N06AX11

ATC

mirtazapine; oral

1.7

30.1

864

5865

R42

ICD-10 Finland

Dizziness and giddiness

1.9

30.0

543

3195

H52.3

ICD-10 Finland

Anisometropia and aniseikonia

41.6

29.9

N03AX12

ATC

gabapentin; oral

2.0

29.7

422

2268

N05AH04

ATC

quetiapine; oral

1.9

29.7

524

3056

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.6

26.5

759

5120

C07AA05

ATC

propranolol; systemic

1.7

25.6

566

3537

N06AX16

ATC

venlafaxine; oral

1.9

25.5

423

2402

SPAT1301

SPAT

No procedures

1.6

25.4

880

6225

H50.5

ICD-10 Finland

Heterophoria

+∞

25.0

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.7

25.0

687

4565

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)

1.6

24.2

739

5047

H52.4

ICD-10 Finland

Presbyopia

5.4

24.2

141

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.5

23.7

1026

7621

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.5

23.7

989

7289

G44.2

ICD-10 Finland

Tension-type headache

1.9

23.4

402

2306

A02BC02

ATC

pantoprazole; systemic

1.5

22.7

1594

13097

F95

ICPC

Strabismus

84.1

22.7

M79.6

ICD-10 Finland

Pain in limb

1.5

22.7

932

6827

3504

FHL

Retroposition of two muscles

231.7

22.6

SPAT1263

SPAT

Sampling

1.5

22.6

1217

9459

N02AX02

ATC

tramadol; systemic, rectal

1.5

22.4

979

7265

ZXA10

NOMESCO Finland

Bilateral

1.8

22.3

464

2833

N06AX21

ATC

duloxetine; oral

2.0

22.1

306

1619

3784A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Heterophoria[ESOPHORIA]

+∞

21.9

N02CC01

ATC

sumatriptan; nasal, systemic, rectal

1.8

21.7

446

2712

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

2.1

21.5

261

1310

XA800

NOMESCO Finland

Neuropsychological investigation

2.8

21.5

141

517

N03AE01

ATC

clonazepam; systemic

2.6

21.3

159

629

3781A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS CONCOMITANS DIVERGENS]

+∞

20.9

H04.10

ICD-10 Finland

Dry eye syndrome

2.0

20.7

265

1358

H02AB06

ATC

prednisolone; systemic

1.5

20.5

1153

8987

G47.3

ICD-10 Finland

Sleep apnoea

1.7

20.4

480

3031

A02BC01

ATC

omeprazole; systemic

1.6

20.1

656

4524

TAB00

NOMESCO Finland

Lumbar puncture

2.6

19.9

147

579

ZXE10

NOMESCO Finland

More than one and less than three hours

1.5

19.9

893

6626

G43.1

ICD-10 Finland

Migraine with aura [classical migraine]

2.1

19.9

238

1188

CEC60

NOMESCO Finland

Transposition of extraocular muscle with adjustable suture

+∞

19.8

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

1.8

19.8

349

2017

CEW99

NOMESCO Finland

Other operation on extraocular muscle

201.3

19.6

N02BE01

ATC

paracetamol; systemic, rectal

1.5

19.4

2292

20574

CK2X4

NOMESCO Finland

Optical coherence tomography (OCT) of ocular fundus

2.2

19.4

204

961

SPAT1310

SPAT

Counselling related to known health issue

1.5

19.1

905

6782

R06.0

ICD-10 Finland

Dyspnoea

1.6

18.7

576

3907

S06.0

ICD-10 Finland

Concussion

1.9

18.7

298

1659

H52.5

ICD-10 Finland

Disorders of accommodation

38.6

18.5

N06AB10

ATC

escitalopram; oral

1.6

18.5

581

3958

A06AC01

ATC

ispaghula (psylla seeds); oral

1.6

18.5

552

3713

SPAT1312

SPAT

General health counselling

1.5

18.4

977

7477

N04BC05

ATC

pramipexole; oral

2.3

18.4

181

827

M54.5

ICD-10 Finland

Low back pain

1.5

18.4

859

6403

CE2W4

NOMESCO Finland

Eye movement mapping

30.2

18.3

F32.9

ICD-10 Finland

Depressive episode, unspecified

1.7

18.2

405

2510

SPAT1260

SPAT

Consultation of another employee

1.6

18.2

478

3109

R53

ICD-10 Finland

Malaise and fatigue

1.6

18.1

517

3438

Z96.1

ICD-10 Finland

Presence of intraocular lens

2.0

18.0

224

1137

N06AA09

ATC

amitriptyline; systemic

2.0

18.0

234

1206

A02BC05

ATC

esomeprazole; systemic

1.5

17.9

966

7405

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

1.8

17.9

347

2063

R5110

NOMESCO Finland

Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it

1.9

17.8

269

1467

G43.9

ICD-10 Finland

Migraine, unspecified

2.1

17.7

203

995

G04BD12

ATC

mirabegron; oral

2.0

17.7

224

1144

UJF32

NOMESCO Finland

Coloscopy

1.6

17.6

567

3881

N03AG01

ATC

valproic acid; systemic, rectal

2.3

17.4

169

768

N05BA04

ATC

oxazepam; oral

1.5

17.2

614

4305

A02BC03

ATC

lansoprazole; oral

1.5

17.0

645

4582

N03AX11

ATC

topiramate; oral

3.1

17.0

324

J01AA02

ATC

doxycycline; systemic

1.4

16.8

1943

17052

Z01.8

ICD-10 Finland

Other specified special examinations

1.6

16.7

540

3695

J01DB01

ATC

cefalexin; oral

1.5

16.6

2276

20589

WX140

NOMESCO Finland

Parabulbar anesthesy

3.1

16.6

309

R01AD12

ATC

fluticasone furoate; nasal

1.4

16.3

862

6560

L03

ICPC

Low back symptom/complaint

1.5

16.2

651

4676

R07.4

ICD-10 Finland

Chest pain, unspecified

1.5

16.0

578

4054

SPAT1249

SPAT

Treatment-related counselling outside office

1.4

15.9

1099

8782

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

1.9

15.8

241

1321

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.6

15.7

454

3021

SPAT1153

SPAT

Removal of sutures

1.5

15.7

733

5437

3780B

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONVERGENS ALTERNANS]

+∞

15.6

37302

ICD-8 Finland

Strabismus, Concomitans sursum sive deorsum vergens

+∞

15.6

H50.3

ICD-10 Finland

Intermittent heterotropia

+∞

15.6

N06AB04

ATC

citalopram; systemic

1.5

15.5

523

3609

J45.9

ICD-10 Finland

Asthma, unspecified

1.6

15.4

445

2955

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.4

15.4

1105

8875

Z50.8

ICD-10 Finland

Care involving use of other rehabilitation procedures

2.1

15.4

183

912

N06AB06

ATC

sertraline; oral

1.7

15.3

318

1927

N06CA01

ATC

amitriptyline and psycholeptics; systemic

1.9

15.2

239

1324

XKD00

NOMESCO Finland

Uroflowmetry

1.8

15.2

266

1528

Z3231

NOMESCO Finland

Registered nurse

1.5

15.2

683

5016

H25.1

ICD-10 Finland

Senile nuclear cataract

1.6

15.2

379

2421

N03AX09

ATC

lamotrigine; oral

2.2

15.2

158

741

F05

ICPC

Visual disturbance other

3.1

15.1

279

203

Kela drug reimbursment

Chronic asthma and similar chronic obstructive pulmonary diseases

1.6

15.0

476

3235

ZXE00

NOMESCO Finland

One hour or less

1.4

14.8

1014

8059

SPAT1240

SPAT

Therapeutic discussion

1.6

14.7

365

2326

N04BA02

ATC

levodopa and decarboxylase inhibitor; oral

3.3

14.7

229

SPAT1222

SPAT

Counselling/guidance promoting independent living

1.7

14.6

326

2019

3780A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Convergent concomitant strabismus[STRABISMUS CONCOMITANS CONVERGENS]

+∞

14.6

M54.4

ICD-10 Finland

Lumbago with sciatica

1.6

14.5

396

2592

UKC02

NOMESCO Finland

Cystoscopy

1.7

14.4

290

1742

N05CF01

ATC

zopiclone; oral

1.5

14.4

689

5119

R01AD09

ATC

mometasone; nasal

1.4

14.4

1200

9852

F32.2

ICD-10 Finland

Severe depressive episode without psychotic symptoms

1.9

14.3

212

1150

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

1.9

14.2

215

1172

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

1.6

14.2

428

2872

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

1.7

14.2

325

2026

M01AE02

ATC

naproxen; oral, rectal

1.3

14.0

1568

13477

G20

ICD-10 Finland

Parkinson disease

3.3

13.9

212

UDC00

NOMESCO Finland

Ear microscopy

2.0

13.8

188

986

N17

ICPC

Vertigo/dizziness

1.8

13.8

266

1577

M03BX02

ATC

tizanidine; oral

1.3

13.6

1572

13545

110

Kela drug reimbursment

Parkinson's disease and comparable movement disrorders

3.4

13.6

189

A02BA02

ATC

ranitidine; systemic

1.6

13.4

398

2659

R20.2

ICD-10 Finland

Paraesthesia of skin

2.0

13.4

179

936

WX408

NOMESCO Finland

General anesthesy, balanced

1.4

13.3

655

4882

H43.8

ICD-10 Finland

Other disorders of vitreous body

2.0

13.2

177

925

R25.1

ICD-10 Finland

Tremor, unspecified

3.1

13.1

238

M03BX01

ATC

baclofen; systemic

3.7

13.1

153

F33.2

ICD-10 Finland

Recurrent depressive disorder, current episode severe without psychotic symptoms

2.1

13.1

148

721

R52.2

ICD-10 Finland

Other chronic pain

2.7

12.9

346

TPH04

NOMESCO Finland

Cathetrisation of vein

1.5

12.8

454

3156

H03AA01

ATC

levothyroxine sodium; systemic

1.5

12.7

559

4066

J45.0

ICD-10 Finland

Predominantly allergic asthma

1.7

12.7

259

1560

NA1BG

NOMESCO Finland

Cervical spine MRI examination with high intensity magnet

2.1

12.7

137

657

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

2.1

12.7

152

761

SPAT1256

SPAT

Intramuscular and subcutaneous injection

1.4

12.6

1017

8252

H53.9

ICD-10 Finland

Visual disturbance, unspecified

2.8

12.6

279

CEC50

NOMESCO Finland

Advancement of extraocular muscle

+∞

12.5

H50.4

ICD-10 Finland

Other and unspecified heterotropia

+∞

12.5

M25.5

ICD-10 Finland

Pain in joint

1.4

12.5

705

5382

R06AE07

ATC

cetirizine; oral

1.3

12.5

1183

9836

R03DC03

ATC

montelukast; oral

1.5

12.5

415

2845

G43.0

ICD-10 Finland

Migraine without aura [common migraine]

1.9

12.5

195

1077

R03BA01

ATC

beclometasone; inhalant

1.6

12.4

326

2111

M01AG02

ATC

tolfenamic acid; oral, rectal

1.5

12.2

391

2655

N04BD01

ATC

selegiline; oral

4.6

12.2

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

1.6

12.0

339

2234

R03BA05

ATC

fluticasone; inhalant

1.5

11.9

481

3435

H26.4

ICD-10 Finland

After-cataract

2.0

11.9

144

722

R01AD01

ATC

beclometasone; nasal

1.6

11.8

362

2432

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

1.6

11.8

303

1945

CJB10

NOMESCO Finland

Laser discission of secondary cataract

2.1

11.8

130

629

XKD06

NOMESCO Finland

Physiologic investigation of micturition

3.0

11.7

227

X59

ICD-10 Finland

Exposure to unspecified factor

1.5

11.7

446

3148

A01

ICPC

Pain general/multiple sites

1.9

11.7

181

1000

WX402

NOMESCO Finland

General anaesthesia

1.5

11.7

415

2884

K21.9

ICD-10 Finland

Gastro-oesophageal reflux disease without oesophagitis

1.7

11.6

227

1351

M01AE03

ATC

ketoprofen; systemic, rectal

1.4

11.6

811

6410

M47.82

ICD-10 Finland

Other spondylosis, cervical region

2.4

11.5

383

M48.0

ICD-10 Finland

Spinal stenosis

1.8

11.5

217

1276

3508

FHL

Transposition or anteposition

+∞

11.5

S18

ICPC

Laceration/cut

1.3

11.4

955

7762

K07.60

ICD-10 Finland

Snapping jaw

2.0

11.4

149

771

SPAT1253

SPAT

Initiation, adjustment, discontinuation or repetition of medication

1.4

11.4

853

6810

C07AB07

ATC

bisoprolol; oral

1.3

11.4

882

7082

SHA02

NOMESCO Finland

Correction of physiology of bite - basic therapy visit

1.8

11.3

207

1206

SPAT1097

SPAT

Recording of ECG

1.6

11.3

295

1905

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.3

11.3

1309

11161

N04BC04

ATC

ropinirole; oral

5.1

11.2

N01

ICPC

Headache

1.5

11.2

386

2667

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

2.1

11.1

118

563

H06.2*E05.9

ICD-10 Finland

Dysthyroid exophthalmos

7.1

11.0

M01AX17

ATC

nimesulide; oral

1.4

11.0

491

3578

L29

ICPC

Musculoskeletal sympt/complt other

1.8

11.0

186

1058

Z01.5

ICD-10 Finland

Diagnostic skin and sensitization tests

1.6

11.0

265

1676

R41.8

ICD-10 Finland

Other and unspecified symptoms and signs involving cognitive functions and awareness

1.9

10.9

159

857

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

1.4

10.9

517

3809

N05BA01

ATC

diazepam; systemic, rectal

1.6

10.9

292

1898

R51

ICD-10 Finland

Headache

1.9

10.9

151

802

SAA01

NOMESCO Finland

Simple examination of mouth

1.3

10.9

2001

18150

Z50.9

ICD-10 Finland

Care involving use of rehabilitation procedure, unspecified

2.3

10.9

421

G43.3

ICD-10 Finland

Complicated migraine

3.0

10.9

201

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

1.7

10.8

213

1269

R52.1

ICD-10 Finland

Chronic intractable pain

4.9

10.8

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.4

10.8

650

5003

A04

ICPC

Weakness/tiredness general

1.5

10.7

348

2365

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

1.5

10.7

424

3013

F45.4

ICD-10 Finland

Persistent somatoform pain disorder

3.3

10.6

165

N04BB01

ATC

amantadine; oral

3.6

10.6

129

M79.7

ICD-10 Finland

Fibromyalgia

2.3

10.6

434

XKC03

NOMESCO Finland

Water cystometry

2.6

10.6

300

J01CA04

ATC

amoxicillin; systemic

1.4

10.6

2348

21849

CA1CG

NOMESCO Finland

Eye and orbita extensive MRI examination with high intensity magnet

5.5

10.5

H49.0

ICD-10 Finland

Third [oculomotor] nerve palsy

110.4

10.4

3783A

ICD-9 Finland

Strabismus and other disorders of binocular eye movements, Other and unspecified heterotropia

+∞

10.4

J01FA10

ATC

azithromycin; systemic

1.3

10.4

1682

14934

H25.0

ICD-10 Finland

Senile incipient cataract

2.2

10.3

105

491

C03CA01

ATC

furosemide; systemic

1.5

10.2

429

3084

R11

ICD-10 Finland

Nausea and vomiting

1.7

10.2

209

1261

H40.0

ICD-10 Finland

Glaucoma suspect

1.9

10.2

142

757

M79.1

ICD-10 Finland

Myalgia

1.5

10.2

323

2186

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.4

10.1

628

4852

E0000UV

ATC

1.3

10.1

1027

8555

NA1AD

NOMESCO Finland

Cervical spine CT examination

2.3

10.0

418

M03BC01

ATC

orphenadrine (citrate); systemic

1.4

10.0

566

4302

SPAT1033

SPAT

Irrigation or wax removal of outer auditory canal

1.5

10.0

348

2407

R01AD08

ATC

fluticasone; nasal

1.4

10.0

701

5524

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.3

9.9

1396

12139

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

2.0

9.9

127

654

A06AD11

ATC

lactulose; oral

1.6

9.9

256

1649

M79.0

ICD-10 Finland

Rheumatism, unspecified

2.2

9.9

435

R03AK07

ATC

formoterol and budesonide; inhalant

1.4

9.9

451

3296

N06BA04

ATC

methylphenidate; oral

2.3

9.8

395

M75.1

ICD-10 Finland

Rotator cuff syndrome

1.4

9.8

475

3510

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.3

9.8

1440

12584

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

2.4

9.8

338

K59.09

ICD-10 Finland

Constipation, unspecified

2.0

9.8

130

679

SPAT1325

SPAT

Vaccination

1.3

9.6

827

6711

Z03.80

ICD-10 Finland

Observation for other suspected diseases and conditions

2.2

9.6

448

P74

ICPC

Anxiety disorder/anxiety state

1.9

9.6

129

678

J01FA06

ATC

roxithromycin; oral

1.3

9.5

936

7741

G40.9

ICD-10 Finland

Epilepsy, unspecified

2.4

9.5

329

L01

ICPC

Neck symptom/complaint

1.5

9.5

345

2404

N02AJ06

ATC

codeine and paracetamol; systemic

1.3

9.5

883

7247

ZXA00

NOMESCO Finland

Right side

1.4

9.5

532

4034

SHA03

NOMESCO Finland

Correction of physiology of bite - demanding therapy visit

2.2

9.5

423

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.3

9.5

1105

9357

ZXA05

NOMESCO Finland

Left side

1.4

9.5

500

3750

111

Kela drug reimbursment

Epilepsy and comparable convulsive disorders

2.0

9.4

123

640

N06AX12

ATC

bupropion; oral

1.7

9.4

176

1037

37001

ICD-8 Finland

Refractive errors, Hypermetropia. Hyperopia

+∞

9.4

37002

ICD-8 Finland

Refractive errors, Myopia

+∞

9.4

ZXD05

NOMESCO Finland

Urgent procedure

1.3

9.3

739

5927

R03AK06

ATC

salmeterol and fluticasone; inhalant

1.5

9.3

297

2015

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

1.7

9.3

187

1126

D07AB02

ATC

hydrocortisone butyrate; topical

1.3

9.2

674

5334

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

1.7

9.2

199

1223

J01FF01

ATC

clindamycin; systemic

1.4

9.1

607

4736

F90.0

ICD-10 Finland

Disturbance of activity and attention

2.0

9.1

108

542

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.4

9.1

588

4563

SHB00

NOMESCO Finland

Prepation and fitting of bite rail to mouth

1.5

9.1

280

1884

M02AA07

ATC

piroxicam; topical

1.3

9.1

748

6028

N06AX03

ATC

mianserin; oral

2.1

9.0

103

507

M54.9

ICD-10 Finland

Dorsalgia, unspecified

1.6

9.0

254

1674

J02AC01

ATC

fluconazole; systemic

1.3

9.0

1026

8648

H02AB09

ATC

hydrocortisone; systemic

2.4

8.9

295

SPAT1211

SPAT

Application of soft bandage

1.6

8.9

235

1520

L17

ICPC

Foot/toe symptom/complaint

1.4

8.9

604

4723

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

1.6

8.8

223

1425

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

1.7

8.8

164

963

J45.1

ICD-10 Finland

Nonallergic asthma

1.7

8.8

176

1056

DM1AI

NOMESCO Finland

Cone beam CT of paranasal sinus

2.5

8.8

280

H40.11

ICD-10 Finland

Low pressure glaucoma

3.3

8.8

128

R56.8

ICD-10 Finland

Other and unspecified convulsions

1.9

8.8

127

688

H50

ICD-10 Finland

Other strabismus

50.1

8.7

Z63.7

ICD-10 Finland

Other stressful life events affecting family and household

2.6

8.7

233

C09CA06

ATC

candesartan; oral

1.4

8.7

440

3277

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

1.6

8.6

218

1396

SPAT1215

SPAT

Assessment of need for medical rehabilitation

2.0

8.6

111

575

R06AX27

ATC

desloratadine; oral

1.3

8.6

747

6057

R05DA20

ATC

opium alkaloids and derivatives - combinations

1.3

8.6

607

4772

G04CA02

ATC

tamsulosin; oral

1.5

8.5

278

1892

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

1.7

8.5

183

1125

N39.4

ICD-10 Finland

Other specified urinary incontinence

1.7

8.5

169

1013

PA7AD

NOMESCO Finland

CT angiography of head and neck vasculature

2.7

8.5

213

J01EA01

ATC

trimethoprim; systemic

1.3

8.4

601

4734

R03BA08

ATC

ciclesonide; inhalant

1.6

8.4

195

1221

WX100

NOMESCO Finland

Conjunctival surface anesthesia

1.7

8.4

170

1025

TCG00

NOMESCO Finland

Protection of cornea and sclera with soft lens

12.8

8.4

M02AA10

ATC

ketoprofen; topical

1.5

8.3

325

2298

K58.0

ICD-10 Finland

Irritable bowel syndrome with diarrhoea

1.8

8.3

143

818

183

Kela drug reimbursment

Lamotrigin and topiramate

3.6

8.3

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

1.4

8.3

427

3183

R06AX22

ATC

ebastine; oral

1.4

8.3

410

3037

G35

ICD-10 Finland

Multiple sclerosis

2.8

8.3

186

SPAT1210

SPAT

Application of cast or individual aid

1.9

8.3

110

576

N06AB03

ATC

fluoxetine; oral

1.5

8.2

303

2115

N05AH03

ATC

olanzapine; systemic

1.7

8.2

153

897

F51.0

ICD-10 Finland

Nonorganic insomnia

1.5

8.2

321

2270

T36

ICD-10 Finland

Poisoning by systemic antibiotics

1.8

8.2

125

689

H57.1

ICD-10 Finland

Ocular pain

2.1

8.1

442

F41.2

ICD-10 Finland

Mixed anxiety and depressive disorder

1.5

8.1

263

1790

M01AB05

ATC

diclofenac; systemic, rectal

1.2

8.1

1576

14115

M54.1

ICD-10 Finland

Radiculopathy

2.1

8.0

400

M01AC06

ATC

meloxicam; systemic, rectal

1.3

8.0

783

6441

N03AF02

ATC

oxcarbazepine; oral

2.1

8.0

389

ZXD20

NOMESCO Finland

Day surgery

1.5

8.0

286

1987

M01AH05

ATC

etoricoxib; oral

1.2

8.0

1389

12269

M54.6

ICD-10 Finland

Pain in thoracic spine

1.7

8.0

161

969

A28

ICPC

Limited function/disability NOS

1.6

8.0

232

1537

AA3AD

NOMESCO Finland

CT of face

5.9

8.0

SPAT1053

SPAT

Memory test

1.6

8.0

209

1351

G04CA01

ATC

alfuzosin; oral

1.7

7.9

152

900

R06AX13

ATC

loratadine; oral

1.4

7.9

396

2934

E000001

ATC

1.3

7.9

531

4134

Z2445

NOMESCO Finland

Psychologist

1.8

7.9

131

744

N87

ICPC

Parkinsonism

3.9

7.9

SAA03

NOMESCO Finland

Extended examination of mouth

1.3

7.9

1088

9345

C10AC01

ATC

colestyramine; oral

2.5

7.9

252

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

2.1

7.8

411

NA7CG

NOMESCO Finland

Spine and spinal cord extensive MRI examination with high intensity magnet

3.3

7.8

113

N05AX08

ATC

risperidone; systemic

1.7

7.8

161

975

L86

ICPC

Back syndrome with radiating pain

1.8

7.7

125

703

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.3

7.7

727

5949

J01MA14

ATC

moxifloxacin; systemic

1.6

7.7

173

1074

R01BA52

ATC

pseudoephedrine, combinations; oral

1.3

7.6

664

5373

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

1.8

7.6

126

714

CS5Z4

NOMESCO Finland

Specialised imaging for glaucoma

2.8

7.6

160

R03BA02

ATC

budesonide; inhalant

1.4

7.6

417

3142

G04BD08

ATC

solifenacin; oral

1.8

7.6

117

650

CA1BG

NOMESCO Finland

Eye and orbita MRI examination with high intensity magnet

6.7

7.6

SPAT1262

SPAT

Handing over of treatment supplies

1.4

7.6

334

2419

SPAT1234

SPAT

Support of social functional capacity

2.0

7.6

495

S21

ICPC

Skin texture symptom/complaint

1.5

7.6

275

1919

JN3AD

NOMESCO Finland

Abdominal CT examination

1.7

7.5

145

863

157

Kela drug reimbursment

Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)

3.4

7.5

101

SPAT1307

SPAT

Psychosocial counselling and guidance

1.5

7.5

225

1503

SPAT1216

SPAT

Assessment of functional ability

1.5

7.4

275

1922

M54.2

ICD-10 Finland

Cervicalgia

1.7

7.4

156

952

H51.8

ICD-10 Finland

Other specified disorders of binocular movement

80.3

7.4

XQ800

NOMESCO Finland

Prick test

1.5

7.4

217

1443

R10.1

ICD-10 Finland

Pain localized to upper abdomen

1.4

7.4

360

2658

SPAT1306

SPAT

Counselling and guidance related to nutrition and weight management

1.4

7.4

317

2283

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

1.5

7.4

230

1551

R5140

NOMESCO Finland

Monitoring the use of the aid

1.6

7.4

189

1214

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

1.8

7.4

119

672

WX142

NOMESCO Finland

Sub-tenon anesthesy

8.4

7.3

F33.9

ICD-10 Finland

Recurrent depressive disorder, unspecified

1.8

7.3

118

666

M01AH01

ATC

celecoxib; oral (coxibs)

1.4

7.3

353

2601

CEC20

NOMESCO Finland

Recession and advancement of extraocular muscle

+∞

7.3

CEC40

NOMESCO Finland

Resection and advancement of extraocular muscle

+∞

7.3

R50.9

ICD-10 Finland

Fever, unspecified

1.4

7.3

333

2430

AA4CG

NOMESCO Finland

Extensive MRI examination of sella turcica with high intensity magnet

3.5

7.3

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.3

7.3

648

5258

Z3229

NOMESCO Finland

Other healthcare associate professional

1.6

7.2

178

1132

A98

ICPC

Health maint/preventive medicine

1.6

7.2

2835

27623

J01EE02

ATC

sulfadiazine and trimethoprim; systemic

1.3

7.2

748

6191

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

1.6

7.2

170

1071

WX720

NOMESCO Finland

Own respiration

2.0

7.2

402

R39.1

ICD-10 Finland

Other difficulties with micturition

2.4

7.2

229

H35.38

ICD-10 Finland

Preretinal fibrosis of the macula

2.4

7.2

229

P29

ICPC

Psychological sympt/compl other

1.6

7.2

176

1123

N05CF02

ATC

zolpidem; oral

1.4

7.2

394

2973

TDM10

NOMESCO Finland

Puncture of maxillary antrum

1.9

7.1

528

L30.9

ICD-10 Finland

Dermatitis, unspecified

1.4

7.1

400

3028

XX3DW

NOMESCO Finland

Time consuming IT work

1.6

7.1

194

1268

D12

ICPC

Constipation

2.2

7.1

327

182

Kela drug reimbursment

Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide

2.5

7.0

217

L28

ICPC

Limited function/disability (L)

1.5

7.0

267

1878

109

Kela drug reimbursment

Multiple sclerosis

3.0

7.0

129

A03FA01

ATC

metoclopramide; systemic, rectal

1.4

7.0

432

3320

WX002

NOMESCO Finland

Sedation and analgesia

1.4

7.0

390

2947

ZYC01

NOMESCO Finland

Remote contact by phone

1.8

7.0

113

637

R02

ICPC

Shortness of breath/dyspnoea

1.5

7.0

258

1808

R00.2

ICD-10 Finland

Palpitations

1.6

6.9

166

1052

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.2

6.9

1268

11197

XCK10

NOMESCO Finland

Photography of fundus of eye

1.6

6.9

175

1122

WX704

NOMESCO Finland

Intubation

1.6

6.9

156

972

N05AX12

ATC

aripiprazole; systemic

1.8

6.9

109

610

KH1AD

NOMESCO Finland

CT of urinary organs

2.2

6.9

312

KH1AE

NOMESCO Finland

Urinary tract ultrasound examination

1.8

6.9

107

595

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.3

6.9

838

7067

S13.4

ICD-10 Finland

Sprain and strain of cervical spine

1.9

6.9

101

551

SPAT1305

SPAT

Counselling and guidance related to physical exercise

1.5

6.9

205

1368

SPAT1254

SPAT

Administration of medicine

1.4

6.9

355

2645

N02AA05

ATC

oxycodone; systemic

1.5

6.9

230

1579

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

1.7

6.9

147

903

193

Kela drug reimbursment

Rasagiline

4.8

6.8

WX110

NOMESCO Finland

Local anesthesy

1.2

6.8

1883

17361

F60.9

ICD-10 Finland

Personality disorder, unspecified

2.7

6.8

166

R05FA02

ATC

opium derivatives and expectorants; systemic

1.2

6.8

925

7903

SAA02

NOMESCO Finland

Basic examination of mouth

1.2

6.8

1861

17140

CS444

NOMESCO Finland

Visual field testing with Octopus automated perimetry

2.2

6.8

299

N03AX14

ATC

levetiracetam; systemic

2.2

6.7

276

ZXM10

NOMESCO Finland

Intraoperative use of conventional X-ray imaging

1.8

6.7

117

678

S01GX01

ATC

cromoglicic acid; ophthalmic

1.3

6.7

512

4060

P76

ICPC

Depressive disorder

1.6

6.7

174

1128

F33.10

ICD-10 Finland

Recurrent depression, moderate episode without somatic syndrome

1.6

6.7

147

913

F41.9

ICD-10 Finland

Anxiety disorder, unspecified

1.4

6.7

268

1910

UDQ12

NOMESCO Finland

Flexible laryngoscopy

1.8

6.6

112

640

J01DA01

ATC

[U] cefalexin; systemic

1.2

6.6

1553

14051

303

Kela drug reimbursment

Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)

3.1

6.6

106

SPAT1148

SPAT

Treatment of chronic ulcer or burn

1.5

6.6

234

1621

J05AB01

ATC

aciclovir; systemic

1.3

6.6

477

3749

H02.3

ICD-10 Finland

Blepharochalasis

1.8

6.6

114

659

M21.4

ICD-10 Finland

Flat foot [pes planus] (acquired)

2.1

6.6

340

KMAK

NOMESCO Finland

1.2

6.6

1346

12005

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.3

6.6

575

4645

N02CC03

ATC

zolmitriptan; nasal, oral

1.7

6.6

141

866

P03

ICPC

Feeling depressed

1.4

6.6

282

2035

I49.9

ICD-10 Finland

Cardiac arrhythmia, unspecified

1.5

6.6

239

1668

J34.2

ICD-10 Finland

Deviated nasal septum

1.8

6.5

102

569

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

2.4

6.5

215

A02BC04

ATC

rabeprazole; oral

1.6

6.5

177

1160

AAF20

NOMESCO Finland

Revision of shunt of ventricle of brain

6.8

6.5

I49.3

ICD-10 Finland

Ventricular premature depolarization

1.7

6.5

132

801

JN3BD

NOMESCO Finland

Extensive abdominal CT

1.5

6.5

202

1362

R03AC12

ATC

salmeterol; inhalant

1.9

6.5

441

D07AC01

ATC

betamethasone; topical

1.3

6.5

739

6177

R03AK11

ATC

formoterol and fluticasone; inhalant

2.3

6.5

229

N03AF01

ATC

carbamazepine; oral, rectal

1.8

6.4

530

SHA04

NOMESCO Finland

Correction of physiology of bite - very demanding therapy visit

2.7

6.4

149

AA1CM

NOMESCO Finland

Extensive MRI examination of brain with 3 Tesla magnet

2.3

6.4

241

NH3EA

NOMESCO Finland

Feet X-ray examination with load

2.4

6.4

203

D32.02

ICD-10 Finland

Benign tumor of the meninges at the base of the brain

4.3

6.4

XJH00

NOMESCO Finland

Transanal ultrasonography

2.0

6.4

420

K58.9

ICD-10 Finland

Irritable bowel syndrome without diarrhoea

1.9

6.4

434

N06AG02

ATC

moclobemide; oral

1.9

6.4

507

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

1.5

6.4

245

1728

NA1BA

NOMESCO Finland

Cervical spine extensive X-ray examination without contrast

3.5

6.4

H35.39

ICD-10 Finland

Degeneration of macula and posterior pole

2.5

6.4

186

S01GX08

ATC

ketotifen; ophthalmic

1.8

6.3

510

R47.1

ICD-10 Finland

Dysarthria and anarthria

4.4

6.3

WX723

NOMESCO Finland

CPAP therapy

2.0

6.3

346

TKC22

NOMESCO Finland

Catheterisation instruction

2.7

6.3

145

R06.5

ICD-10 Finland

Mouth breathing

1.5

6.3

179

1182

M47.9

ICD-10 Finland

Spondylosis, unspecified

2.2

6.3

257

E03.89

ICD-10 Finland

Other specified hypothyroidism

2.0

6.3

389

M70.6

ICD-10 Finland

Trochanteric bursitis

1.5

6.3

228

1591

G81.9

ICD-10 Finland

Hemiplegia, unspecified

3.7

6.3

G23.9

ICD-10 Finland

Degenerative disease of basal ganglia, unspecified

18.0

6.3

N06AB05

ATC

paroxetine; oral

1.6

6.3

138

858

H50.39

ICD-10 Finland

Intermittent heterotropia

+∞

6.3

H50.6

ICD-10 Finland

Mechanical strabismus

+∞

6.3

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

1.8

6.2

505

R01AD58

ATC

fluticasone, combinations; inhalant, nasal

1.3

6.2

533

4291

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.2

6.2

1427

12848

J46

ICD-10 Finland

Status asthmaticus

2.1

6.2

293

G03BA03

ATC

testosterone; systemic, rectal, sublingual, transdermal

1.9

6.2

448

P99

ICPC

Psychological disorders other

2.0

6.2

355

R96

ICPC

Asthma

1.5

6.2

194

1310

M89.0

ICD-10 Finland

Algoneurodystrophy

3.6

6.2

TDW99

NOMESCO Finland

Other minor procedure in surgery of ear, nose and larynx

2.1

6.2

333

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

1.6

6.2

137

854

P01

ICPC

Feeling anxious/nervous/tense

1.4

6.2

356

2707

PA6BD

NOMESCO Finland

Extensive CT of neck arteries

2.0

6.1

372

R35

ICD-10 Finland

Polyuria

1.7

6.1

108

630

SPAT1229

SPAT

Assessment of need for aid

1.6

6.1

135

840

SPAT1104

SPAT

Monitoring of emergency patient

1.6

6.1

135

840

L03AX13

ATC

glatiramer acetate; parenteral

4.7

6.1

N04BD02

ATC

rasagiline; oral

4.0

6.1

ICD-10 Finland

2.3

6.1

224

D07AA02

ATC

hydrocortisone; topical

1.4

6.1

362

2765

H02AB04

ATC

methylprednisolone; systemic

1.4

6.0

296

2187

G62.9

ICD-10 Finland

Polyneuropathy, unspecified

2.2

6.0

281

R74

ICPC

Upper respiratory infection acute

1.2

6.0

818

6968

M53.0

ICD-10 Finland

Cervicocranial syndrome

1.5

6.0

195

1328

NAME	H7_HETEROPHORIA
CONTROL_EXCLUDE	H7_OCUMUSCLE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H505
HD_ICD_9	3784
HD_ICD_8	37303
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H505
COD_ICD_9	3784
COD_ICD_8	37303
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
H7_HETEROPHORIA	1.155 [0.95, 1.41]	0.151
Birth year	0.992 [0.98, 1.0]	0.064

Parameter	HR [95% CI]	p-value
H7_HETEROPHORIA	1.287 [1.06, 1.56]	0.01
Birth year	0.987 [0.98, 1.0]	0.005

N-year risk	Females	Males
1	0.067%	0.226%
5	0.553%	1.478%
10	1.46%	3.997%
15	3.001%	7.387%
20	5.346%	11.783%

Heterophoria

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints