Barrett oesophagus

K11_BARRET

Barrett's esophagus: Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K22.7
  • Hospital discharge: ICD-9 5301B
  • Cause of death: ICD-10 K22.7
  • Cause of death: ICD-9 5301B

2 out of 7 registries used, show all original rules.

1730

4. Check minimum number of events

None

1730

5. Include endpoints

None

1730

6. Filter based on genotype QC (FinnGen only)

1730

Control definitions (FinnGen only)

Control exclude
K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K22

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9000 3115 5865
Only index persons 8584 2996 5588
Unadjusted period prevalence (%)
Whole population 0.14 0.09 0.16
Only index persons 0.18 0.11 0.21
Median age at first event (years)
Whole population 66.17 67.73 65.35
Only index persons 66.10 67.56 65.32

-FinnGen-

Key figures

All Female Male
Number of individuals 1730 609 1121
Unadjusted period prevalence (%) 0.39 0.21 0.49
Median age at first event (years) 66.18 66.64 65.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1530
Matched controls
15301
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
87.8
323.0
1383
1478
K22.7
ICD-10 Finland
Barrett oesophagus
4503599627370496.0
323.0
1487
7
K22.1
ICD-10 Finland
Ulcer of oesophagus
3160.7
323.0
420
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
35.9
323.0
628
291
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
139.0
323.0
727
99
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
34.2
268.4
355
134
A02BC02
ATC
pantoprazole; systemic
5.3
166.4
1264
7198
A02BC05
ATC
esomeprazole; systemic
4.2
150.4
886
3760
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
246.5
133.2
135
6
UJD02
NOMESCO Finland
Gastroscopy
15.2
121.2
208
157
UJF32
NOMESCO Finland
Coloscopy
3.3
87.3
568
2303
A02BC03
ATC
lansoprazole; oral
3.2
86.8
598
2525
A02BC01
ATC
omeprazole; systemic
3.1
74.5
537
2286
UJF30
NOMESCO Finland
Ileoscopy through colon
4.8
69.1
254
610
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
6.2
66.9
193
349
A02BA02
ATC
ranitidine; systemic
3.3
65.4
399
1487
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
18.7
64.1
100
57
K29.3
ICD-10 Finland
Chronic superficial gastritis
74.2
62.7
71
10
K22.2
ICD-10 Finland
Oesophageal obstruction
578.9
57.0
56
*
JCA45
NOMESCO Finland
Endoscopic mucosal or submucosal resection in oesophagus
578.9
57.0
56
*
K30
ICD-10 Finland
Functional dyspepsia
5.6
56.7
177
351
D64.9
ICD-10 Finland
Anaemia, unspecified
4.1
55.8
240
664
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
53.8
557
2834
A02BC04
ATC
rabeprazole; oral
4.8
53.3
192
446
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.9
53.2
381
1557
K20
ICD-10 Finland
Oesophagitis
35.5
52.7
68
20
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.3
50.3
285
983
5301B
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[BARRETT'S OESOPHAGUS]
+∞
49.2
47
*
C15.5
ICD-10 Finland
Malignant neoplasm: Lower third of oesophagus
25.5
47.1
66
27
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
62.1
46.6
54
9
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
460.9
45.5
45
*
K92.0
ICD-10 Finland
Haematemesis
13.0
44.0
79
64
R13
ICD-10 Finland
Dysphagia
4.8
43.7
154
347
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
11.5
43.7
83
76
JCA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in oesophagus
+∞
40.8
39
*
K29.7
ICD-10 Finland
Gastritis, unspecified
18.6
39.5
61
34
6241
FHL
Fund application (Nissen)
136.8
37.9
40
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
37.8
756
4971
WX002
NOMESCO Finland
Sedation and analgesia
2.4
36.0
379
1871
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
30.3
35.3
47
16
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
34.7
379
1899
N02BE01
ATC
paracetamol; systemic, rectal
2.4
33.7
1326
11195
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
5.4
32.9
103
203
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
40.0
31.3
39
10
N06AX11
ATC
mirtazapine; oral
2.0
30.3
476
2776
JCC12
NOMESCO Finland
Thoracoscopic or laparoscopic partial oesophagectomy
38.9
30.3
38
10
5301A
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS REFLUENS]
+∞
29.3
28
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
29.2
452
2612
UJC12
NOMESCO Finland
Flexible oesophagoscopy
21.0
29.2
43
21
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
6.4
29.1
78
127
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
28.9
233
985
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
27.9
339
1762
N03AX16
ATC
pregabalin; oral
2.1
27.8
383
2102
K22.9
ICD-10 Finland
Disease of oesophagus, unspecified
48.1
27.5
33
7
K25.7
ICD-10 Finland
Gastric ulcer, Chronic without haemorrhage or perforation
275.7
26.8
27
*
R06.0
ICD-10 Finland
Dyspnoea
2.0
26.8
393
2212
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
26.5
448
2663
K26.9
ICD-10 Finland
Duodenal ulcer, unspecified as acute or chronic, without haemorrhage or perforation
+∞
26.1
25
*
K31.8
ICD-10 Finland
Other specified diseases of stomach and duodenum
+∞
26.1
25
*
M79.6
ICD-10 Finland
Pain in limb
1.9
25.5
529
3379
K22.0
ICD-10 Finland
Achalasia of cardia
+∞
25.1
24
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
25.0
360
2001
A03FA02
ATC
cisapride; oral, rectal
3.3
24.9
132
425
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
254.1
24.7
25
*
K92.1
ICD-10 Finland
Melaena
3.8
24.7
108
298
N02AX02
ATC
tramadol; systemic, rectal
1.8
23.9
664
4639
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
88.2
23.7
26
*
XJC10
NOMESCO Finland
Oesophageal pH monitoring
127.0
23.6
25
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
23.4
229
1069
R03AC02
ATC
salbutamol; inhalant
1.7
23.3
715
5139
AA1AD
NOMESCO Finland
CT of head and brain
1.9
23.2
401
2380
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.0
23.1
143
513
K44
ICD-10 Finland
Diaphragmatic hernia
13.8
22.8
39
29
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
3.3
22.7
122
397
JD1EE
NOMESCO Finland
Ultrasound examination of gastro-oesophageal reflux
29.5
21.9
29
10
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.9
21.7
92
247
K29.8
ICD-10 Finland
Duodenitis
223.0
21.6
22
*
R12
ICD-10 Finland
Heartburn
3.4
21.6
111
349
SPAT1263
SPAT
Sampling
1.7
21.1
619
4344
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
20.9
374
2238
D03
ICPC
Heartburn
5.1
20.8
66
133
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
20.7
252
1295
K31.7
ICD-10 Finland
Polyp of stomach and duodenum
212.8
20.6
21
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
20.5
181
800
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.3
20.4
200
929
D13.0
ICD-10 Finland
Benign neoplasm: Oesophagus
48.7
20.2
24
5
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.0
20.1
279
1513
WX402
NOMESCO Finland
General anaesthesia
2.0
20.0
278
1509
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
20.0
433
2759
R53
ICD-10 Finland
Malaise and fatigue
2.0
19.6
268
1442
K29.1
ICD-10 Finland
Other acute gastritis
20.3
19.1
28
14
D02
ICPC
Abdominal pain epigastric
3.5
19.0
91
271
R51.80
ICD-10 Finland
Headache
2.4
19.0
179
816
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
18.9
306
1757
JBC00
NOMESCO Finland
Gastro-oesophageal antireflux operation
101.3
18.6
20
*
C03CA01
ATC
furosemide; systemic
1.8
18.6
418
2681
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
18.6
682
5040
WX110
NOMESCO Finland
Local anesthesy
1.6
18.0
976
7960
J01MA12
ATC
levofloxacin; systemic
1.9
17.9
279
1575
P01AB01
ATC
metronidazole; oral, rectal
1.7
17.8
514
3543
R11
ICD-10 Finland
Nausea and vomiting
3.0
17.8
107
376
5308A
ICD-9 Finland
Diseases of oesophagus, Other specified disorders of oesophagus[HERNIA HIATUS OESOPHAGI (""""SLIDING HERNIA"""")]
+∞
17.7
17
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
17.7
574
4089
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
17.6
151
654
K25.4
ICD-10 Finland
Gastric ulcer, Chronic or unspecified with haemorrhage
182.0
17.5
18
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
17.5
178
839
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
17.0
925
7493
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
10.9
17.0
32
30
N03AX12
ATC
gabapentin; oral
2.0
17.0
237
1281
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
17.0
547
3878
A02BA03
ATC
famotidine; systemic
3.8
16.9
72
195
C15.9
ICD-10 Finland
Malignant neoplasm: Oesophagus, unspecified
19.5
16.9
25
13
N05CF01
ATC
zopiclone; oral
1.7
16.8
457
3087
H02AB06
ATC
prednisolone; systemic
1.6
16.8
659
4913
N06AB10
ATC
escitalopram; oral
2.0
16.8
243
1332
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
16.6
439
2939
S18
ICPC
Laceration/cut
1.6
16.5
646
4806
JCA98
NOMESCO Finland
Other local endoscopic operation on oesophagus
171.8
16.5
17
*
Z01.2
ICD-10 Finland
Dental examination
1.6
16.5
540
3834
N06AX16
ATC
venlafaxine; oral
2.2
16.4
178
865
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
16.1
167
794
L08
ICPC
Shoulder symptom/complaint
1.8
16.1
290
1721
J01DB01
ATC
cefalexin; oral
1.7
16.1
1185
10299
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.8
15.7
105
396
J45.9
ICD-10 Finland
Asthma, unspecified
1.9
15.7
242
1356
N06AX21
ATC
duloxetine; oral
2.3
15.7
149
679
K25.0
ICD-10 Finland
Gastric ulcer, Acute with haemorrhage
+∞
15.6
15
*
J01FF01
ATC
clindamycin; systemic
1.7
15.6
399
2635
N06AB04
ATC
citalopram; systemic
1.8
15.6
284
1687
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
15.6
247
1400
SPAT1254
SPAT
Administration of medicine
2.0
15.6
208
1104
XJC00
NOMESCO Finland
Oesophageal manometry
86.0
15.6
17
*
WX704
NOMESCO Finland
Intubation
2.6
15.4
120
493
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.5
15.3
766
6012
M54.5
ICD-10 Finland
Low back pain
1.7
15.3
429
2911
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
15.1
253
1459
R63.4
ICD-10 Finland
Abnormal weight loss
3.7
15.1
65
179
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
15.0
230
1287
JBB01
NOMESCO Finland
Laparoscopic repair of paraoesophageal hernia
32.0
14.8
19
6
8140/3-C15.9
ICD-O-3
Adenocarcinoma, NOS, of esophagus, NOS
32.0
14.8
19
6
L03
ICPC
Low back symptom/complaint
1.8
14.7
318
1994
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
2.4
14.6
130
574
R03BB04
ATC
tiotropium bromide; inhalant
2.2
14.6
154
738
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
14.6
126
547
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.8
14.5
263
1558
K44.0
ICD-10 Finland
Diaphragmatic hernia with obstruction, without gangrene
17.2
14.3
22
13
K29.6
ICD-10 Finland
Other gastritis
22.5
14.2
20
9
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
14.1
460
3235
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.7
14.1
356
2336
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
14.1
222
1251
XG410
NOMESCO Finland
Flow-volume spirometry
3.2
14.0
73
234
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
14.0
338
2186
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.1
14.0
159
787
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
14.0
562
4159
WX892
NOMESCO Finland
Monitored bed care
2.3
13.9
133
609
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
4.3
13.7
51
123
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.7
13.5
95
368
XG466
NOMESCO Finland
Sleep oxymetry
3.3
13.5
68
213
K25.3
ICD-10 Finland
Gastric ulcer, Acute without haemorrhage or perforation
141.2
13.5
14
*
A02BD07
ATC
lansoprazole, amoxicillin and clarithromycin; systemic
3.0
13.4
77
263
R02
ICPC
Shortness of breath/dyspnoea
2.0
13.4
170
884
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.2
13.2
70
227
M01AH05
ATC
etoricoxib; oral
1.5
13.2
818
6642
J37.0
ICD-10 Finland
Chronic laryngitis
3.9
13.1
53
139
UJF92
NOMESCO Finland
Capsular endoscopy
5.6
13.0
37
67
L17
ICPC
Foot/toe symptom/complaint
1.6
12.9
348
2319
A04
ICPC
Weakness/tiredness general
2.0
12.9
164
853
R4190
NOMESCO Finland
Nutritional therapy
3.6
12.8
58
167
M25.5
ICD-10 Finland
Pain in joint
1.6
12.8
362
2441
N05AH04
ATC
quetiapine; oral
1.9
12.8
205
1164
K59.09
ICD-10 Finland
Constipation, unspecified
2.6
12.7
95
384
R03BA05
ATC
fluticasone; inhalant
1.8
12.7
225
1318
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
12.7
664
5182
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
12.6
238
1426
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.3
12.6
114
510
WX320
NOMESCO Finland
Spinalanesthesy
1.6
12.3
329
2183
D01
ICPC
Abdominal pain/cramps general
2.2
12.2
131
634
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.6
12.1
361
2461
JCF12
NOMESCO Finland
Endoscopic insertion of prosthetic tube into oesphagus
12.5
12.1
21
17
WX725
NOMESCO Finland
Noninvasive ventilation
2.7
12.1
80
301
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
12.1
254
1570
XJD02
NOMESCO Finland
Peroral endoscopic ultrasonography
8.2
12.1
26
32
TPH07
NOMESCO Finland
Cathetrisation of artery
2.0
12.0
167
897
N05CF02
ATC
zolpidem; oral
1.8
12.0
229
1375
A01
ICPC
Pain general/multiple sites
2.3
11.9
107
476
EBA00
NOMESCO Finland
Extraction of tooth
1.5
11.8
449
3249
J01CA04
ATC
amoxicillin; systemic
1.5
11.8
1082
9431
R60.0
ICD-10 Finland
Localized oedema
2.0
11.7
159
847
K02.1
ICD-10 Finland
Caries of dentine
1.5
11.7
735
5927
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
11.7
415
2953
K22.8
ICD-10 Finland
Other specified diseases of oesophagus
65.5
11.6
13
*
R05
ICPC
Cough
1.7
11.6
286
1854
R42
ICD-10 Finland
Dizziness and giddiness
1.7
11.6
283
1831
J20
ICD-10 Finland
Acute bronchitis
2.1
11.5
131
652
K26.3
ICD-10 Finland
Duodenal ulcer, acute without haemorrhage or perforation
+∞
11.5
11
*
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
+∞
11.5
11
*
K26.0
ICD-10 Finland
Duodenal ulcer, acute with haemorrhage
+∞
11.5
11
*
F10.25
ICD-10 Finland
Alcohol dependence continuous use
4.1
11.4
44
111
A02BA04
ATC
nizatidine; systemic
2.3
11.4
111
512
N05BA04
ATC
oxazepam; oral
1.6
11.3
310
2066
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.9
11.3
164
896
C07AB07
ATC
bisoprolol; oral
1.5
11.3
691
5527
B01AB05
ATC
enoxaparin; parenteral
1.5
11.3
449
3280
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.4
11.2
99
435
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
2.9
11.1
66
233
H02AB07
ATC
prednisone; oral
1.8
11.1
193
1123
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
6.1
11.1
29
48
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.4
11.0
98
432
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
11.0
355
2464
A06AD11
ATC
lactulose; oral
1.8
11.0
190
1101
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
11.0
212
1276
R07.3
ICD-10 Finland
Other chest pain
2.0
11.0
134
686
K29.4
ICD-10 Finland
Chronic atrophic gastritis
14.0
11.0
18
13
B80
ICPC
Iron deficiency anaemia
5.0
11.0
34
69
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
3.4
10.9
52
157
SPAT1262
SPAT
Handing over of treatment supplies
1.6
10.9
290
1914
P15
ICPC
Chronic alcohol abuse
3.1
10.9
58
190
SPAT1255
SPAT
Intravenous administration of medicine
2.2
10.9
108
505
G47.3
ICD-10 Finland
Sleep apnoea
1.6
10.8
334
2293
UJC02
NOMESCO Finland
Rigid oesophagoscopy
7.2
10.8
25
35
R05
ICD-10 Finland
Cough
1.7
10.7
249
1584
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
2.6
10.7
75
293
8140/3-C16.0
ICD-O-3
Adenocarcinoma, NOS, of cardia, NOS
21.6
10.7
15
7
N06AA09
ATC
amitriptyline; systemic
2.0
10.6
139
732
M03BX02
ATC
tizanidine; oral
1.4
10.6
830
6931
D06
ICPC
Abdominal pain localized other
2.3
10.5
101
465
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.6
10.5
78
315
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.3
10.5
100
457
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
10.5
451
3340
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
5.4
10.4
30
56
K22.6
ICD-10 Finland
Gastro-oesophageal laceration-haemorrhage syndrome
+∞
10.4
10
*
JBC91
NOMESCO Finland
Revision antireflux surgery, endoscopic suture repair
+∞
10.4
10
*
N07BB01
ATC
disulfiram; oral
2.5
10.4
80
329
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
10.4
695
5622
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
10.4
484
3645
XF402
NOMESCO Finland
ECG with work load test
1.8
10.3
174
999
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
10.2
122
618
T18.1
ICD-10 Finland
Foreign body in oesophagus
7.5
10.2
23
31
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.7
10.2
232
1467
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.8
10.2
185
1091
M70.6
ICD-10 Finland
Trochanteric bursitis
1.9
10.2
155
862
L28
ICPC
Limited function/disability (L)
1.7
10.1
216
1340
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
4.0
10.1
39
99
A09AA02
ATC
multienzymes (lipase, protease etc.)
4.3
10.1
36
85
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
10.1
125
645
M34.1
ICD-10 Finland
CR(E)ST syndrome
14.7
10.0
16
11
K29.0
ICD-10 Finland
Acute haemorrhagic gastritis
40.3
10.0
12
*
JDA55
NOMESCO Finland
Endoscopic dilatation of stomach, pylorus or anastomosis of stomach
40.3
10.0
12
*
N03AE01
ATC
clonazepam; systemic
2.4
9.9
83
357
PD5AD
NOMESCO Finland
CT of aorta
4.6
9.9
33
73
XQ800
NOMESCO Finland
Prick test
2.4
9.9
83
359
WX290
NOMESCO Finland
Other blockade of nerve
1.4
9.8
530
4098
UJD10
SPAT
NA
5.7
9.8
27
48
D11
ICPC
Diarrhoea
2.0
9.8
121
622
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.4
9.8
79
333
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
9.8
622
4963
F10.24
ICD-10 Finland
Alcohol depence active use
4.2
9.8
36
88
R07.0
ICD-10 Finland
Pain in throat
2.6
9.8
70
278
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
9.8
155
873
A03
ICPC
Fever
1.8
9.7
173
1015
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
2.0
9.5
125
660
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.6
9.5
68
270
G44.2
ICD-10 Finland
Tension-type headache
1.9
9.5
142
785
WZA90
NOMESCO Finland
Other doctors statement
1.6
9.5
296
2033
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
3.2
9.4
47
149
R35
ICD-10 Finland
Polyuria
2.1
9.3
106
525
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
3.0
9.3
53
181
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
2.6
9.3
67
267
WX722
NOMESCO Finland
PEEP
2.3
9.3
82
363
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
9.3
805
6775
R4110
NOMESCO Finland
Physiotherapy
1.5
9.3
371
2691
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
3.0
9.2
53
183
A02BD03
ATC
lansoprazole, amoxicillin and metronidazole; systemic
2.1
9.2
97
467
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.3
9.2
84
379
F10.20
ICD-10 Finland
Alcohol dependence currently independent
3.5
9.2
41
119
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
9.2
512
3978
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.5
9.1
69
283
E0000UV
ATC
NA
1.4
9.1
484
3719
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
5.2
9.1
27
53
D07AB02
ATC
hydrocortisone butyrate; topical
1.5
9.1
351
2528
J01AA02
ATC
doxycycline; systemic
1.4
9.1
1100
9813
C08CA01
ATC
amlodipine; oral
1.4
9.1
534
4184
FN1AD
NOMESCO Finland
CT of coronary arteries
4.7
9.0
29
62
L01
ICPC
Neck symptom/complaint
1.8
9.0
153
883
D13.2
ICD-10 Finland
Benign neoplasm: Duodenum
9.1
9.0
18
20
R52.9
ICD-10 Finland
Pain, unspecified
2.0
9.0
108
547
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
9.0
234
1534
JDA05
NOMESCO Finland
Endoscopic polypectomy in stomach or pylorus
18.7
8.9
13
7
R06.2
ICD-10 Finland
Wheezing
2.8
8.9
57
212
A04.8
ICD-10 Finland
Other specified bacterial intestinal infections
6.1
8.9
23
38
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
8.9
110
566
SAA01
NOMESCO Finland
Simple examination of mouth
1.4
8.9
916
7919
C01DA14
ATC
isosorbide mononitrate; oral
1.7
8.9
201
1268
R06AE07
ATC
cetirizine; oral
1.4
8.9
507
3948
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.9
8.9
129
704
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.6
8.8
285
1967
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.9
8.8
129
708
1300
FHL
Esophagogastroduodenoscopy (also includes staining)
9.5
8.8
17
18
L15
ICPC
Knee symptom/complaint
1.6
8.7
271
1853
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
4.5
8.7
29
65
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.2
8.7
85
395
N05BA12
ATC
alprazolam; oral
1.9
8.6
135
758
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
8.6
227
1492
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
8.6
125
682
A03FA01
ATC
metoclopramide; systemic, rectal
1.6
8.6
250
1681
A28
ICPC
Limited function/disability NOS
1.7
8.5
190
1192
UKC02
NOMESCO Finland
Cystoscopy
1.6
8.5
245
1647
JCA08
NOMESCO Finland
Endoscopic removal of foreign body from oesophagus
27.7
8.5
11
*
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
8.4
734
6141
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
8.4
228
1506
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
8.4
128
714
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.4
8.4
70
302
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.5
8.4
368
2718
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.3
8.4
78
355
C159, 8148, 2
ICD-O-3
NA
+∞
8.3
8
*
K26.4
ICD-10 Finland
Duodenal ulcer, chronic or unspecified with haemorrhage
+∞
8.3
8
*
SPAT1240
SPAT
Therapeutic discussion
2.0
8.3
105
545
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
8.3
218
1431
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
8.2
404
3045
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.0
8.2
98
497
K29.9
ICD-10 Finland
Gastroduodenitis, unspecified
14.6
8.2
13
9
SPAT1310
SPAT
Counselling related to known health issue
1.4
8.2
423
3221
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.6
8.2
197
1264
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.8
8.1
131
743
P03
ICPC
Feeling depressed
2.2
8.1
81
381
A02BX02
ATC
sucralfate; oral
2.6
8.1
56
220
E66.8
ICD-10 Finland
Other obesity
2.5
8.0
62
257
L05
ICPC
Flank/axilla symptom/complaint
2.2
8.0
76
349
D50
ICD-10 Finland
Iron deficiency anaemia
4.3
8.0
28
66
JDA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in stomach or pylorus
22.1
8.0
11
5
N05CD07
ATC
temazepam; oral
1.7
8.0
166
1021
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.8
8.0
48
173
W19
ICD-10 Finland
Unspecified fall
1.9
8.0
124
693
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.1
8.0
83
398
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
2.3
8.0
73
330
GD1AD
NOMESCO Finland
Thorax CT examination
2.3
8.0
68
298
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
3.4
8.0
37
112
K59.1
ICD-10 Finland
Functional diarrhoea
2.4
7.9
65
279
SPAT1097
SPAT
Recording of ECG
1.6
7.9
214
1411
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
1.9
7.9
112
607
J01DA01
ATC
[U] cefalexin; systemic
1.4
7.9
809
6925
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.4
7.9
62
262
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
7.8
322
2341
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.9
7.8
114
626
R50.9
ICD-10 Finland
Fever, unspecified
1.7
7.8
172
1073
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.9
7.8
45
157
N05AA02
ATC
levomepromazine; systemic
2.4
7.8
63
267
N02AA05
ATC
oxycodone; systemic
1.6
7.8
187
1197
J45.1
ICD-10 Finland
Nonallergic asthma
2.1
7.8
84
410
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.7
7.7
157
960
M01AB05
ATC
diclofenac; systemic, rectal
1.4
7.7
924
8092
M54
ICD-10 Finland
Dorsalgia
1.8
7.7
129
739
F51.0
ICD-10 Finland
Nonorganic insomnia
1.8
7.7
138
811
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
7.7
508
4038
SGA01
NOMESCO Finland
Tooth opening as first aid
1.6
7.7
189
1219
C07AA05
ATC
propranolol; systemic
1.6
7.7
213
1418
N17
ICPC
Vertigo/dizziness
1.8
7.7
141
837
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.0
7.7
41
138
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
3.0
7.6
42
144
F34.1
ICD-10 Finland
Dysthymia
3.0
7.6
42
144
D12
ICPC
Constipation
2.7
7.6
50
191
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
7.6
275
1943
U02
ICPC
Urinary frequency/urgency
1.7
7.6
147
886
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
2.1
7.5
82
402
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.5
7.5
55
221
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
3.6
7.5
32
91
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.8
7.5
136
804
SPAT1153
SPAT
Removal of sutures
1.4
7.5
466
3663
SPAT1301
SPAT
No procedures
1.4
7.5
412
3168
M01AE02
ATC
naproxen; oral, rectal
1.3
7.4
711
5995
J45
ICD-10 Finland
Asthma
1.8
7.4
118
668
C03DA01
ATC
spironolactone; oral
1.7
7.4
142
851
C10AA01
ATC
simvastatin; oral
1.4
7.4
658
5485
A11
ICPC
Chest pain NOS
1.9
7.4
104
562
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.4
7.4
61
263
R03DA04
ATC
theophylline; systemic, rectal
2.3
7.4
62
271
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
1.9
7.4
102
549
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
4.4
7.3
25
58
D25
ICPC
Abdominal distension
4.2
7.3
26
63
K26.7
ICD-10 Finland
Duodenal ulcer, chronic without haemorrhage or perforation
+∞
7.3
7
*
JCA42
NOMESCO Finland
Other endoscopic procedure for hemostasis
+∞
7.3
7
*
53094
ICD-8 Finland
Diseases of oesophagus, Oesophagitis
+∞
7.3
7
*
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
2.3
7.3
66
298
R95
ICPC
Chron obstructive pulmonary disease
2.8
7.3
43
154
UJG02
NOMESCO Finland
Proctoscopy
3.2
7.3
36
115
A98
ICPC
Health maint/preventive medicine
1.7
7.2
1417
13492
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.3
7.2
65
292
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.8
7.2
126
735
103
Kela drug reimbursment
Diabetes, insulin-treated
1.4
7.2
386
2951
WVA20
NOMESCO Finland
Medicine administration
3.0
7.1
38
128
N30.0
ICD-10 Finland
Acute cystitis
1.7
7.1
143
872
P01
ICPC
Feeling anxious/nervous/tense
2.1
7.1
73
351
N06AX12
ATC
bupropion; oral
2.4
7.1
59
255
Z97.2
ICD-10 Finland
Presence of dental prosthetic device (complete)(partial)
2.9
7.1
41
144
NG2AA
NOMESCO Finland
Patella X-ray examination
2.9
7.1
41
144
SPAT1260
SPAT
Consultation of another employee
1.5
7.1
235
1632
X58
ICD-10 Finland
Exposure to other specified factors
1.6
7.1
166
1056
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.0
7.0
85
433
A10BA02
ATC
metformin; oral
1.4
7.0
404
3124
C09CA06
ATC
candesartan; oral
1.5
7.0
282
2036
N01
ICPC
Headache
2.0
7.0
89
463
N05BA01
ATC
diazepam; systemic, rectal
1.6
7.0
169
1085
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.4
7.0
337
2524
E61.1
ICD-10 Finland
Iron deficiency
7.0
7.0
16
23
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
1.7
7.0
145
893
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.9
7.0
27
71
C10AA05
ATC
atorvastatin; oral
1.3
7.0
578
4753
SPAT1229
SPAT
Assessment of need for aid
1.9
6.9
106
590
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.7
6.9
157
988
R03BA02
ATC
budesonide; inhalant
1.6
6.9
195
1301
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.5
6.9
299
2193
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
4.3
6.9
24
57
P06
ICPC
Sleep disturbance
1.8
6.9
117
677
Z53.0
ICD-10 Finland
Procedure not carried out because of contraindication
13.8
6.9
11
8
L02
ICPC
Back symptom/complaint
1.9
6.9
98
532
R74
ICPC
Upper respiratory infection acute
1.5
6.9
267
1916
U05
ICPC
Urination problems other
2.2
6.9
68
319
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.5
6.9
245
1725
R52.0
ICD-10 Finland
Acute pain
2.9
6.9
40
142
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
1.9
6.8
96
521
WX720
NOMESCO Finland
Own respiration
2.4
6.8
57
246
S22.3
ICD-10 Finland
Fracture of rib
1.9
6.8
92
492
TQW40
NOMESCO Finland
Remowal of suture of skin
1.9
6.8
98
537
M94.0
ICD-10 Finland
Chondrocostal junction syndrome [Tietze]
3.5
6.8
30
88
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.5
6.8
30
88
K55.2
ICD-10 Finland
Angiodysplasia of colon
6.7
6.8
16
24
K85
ICPC
Elevated blood pressure
1.6
6.8
205
1388
D09
ICPC
Nausea
2.8
6.8
41
150
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.7
6.8
44
167
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.5
6.8
22
49
Z72.1
ICD-10 Finland
Alcohol use
3.7
6.8
27
73
SPAT1325
SPAT
Vaccination
1.4
6.8
465
3703
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
16.8
6.7
10
6
J02AC01
ATC
fluconazole; systemic
1.4
6.7
384
2961
R01AD08
ATC
fluticasone; nasal
1.4
6.7
327
2449
E66
ICD-10 Finland
Obesity
2.4
6.7
52
219
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
6.7
210
1438
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
3.3
6.7
31
95
L76
ICPC
Fracture: other
2.9
6.7
39
139
M50.3
ICD-10 Finland
Other cervical disc degeneration
2.9
6.7
39
139
JN4BD
NOMESCO Finland
Extensive body CT
1.6
6.7
161
1034
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
6.7
142
881
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
6.7
104
585
B82
ICPC
Anaemia other/unspecified
3.0
6.7
36
123
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.6
6.6
171
1114
F41.1
ICD-10 Finland
Generalized anxiety disorder
2.8
6.6
39
140
R01AD09
ATC
mometasone; nasal
1.3
6.6
519
4219
R52.2
ICD-10 Finland
Other chronic pain
2.7
6.6
41
153
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.8
6.6
116
679
ZXA00
NOMESCO Finland
Right side
1.4
6.6
361
2765
R96
ICPC
Asthma
1.8
6.6
107
612
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.3
6.6
30
91
SPAT1216
SPAT
Assessment of functional ability
1.5
6.6
198
1340
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.4
6.5
51
216
A03CA02
ATC
clidinium and psycholeptics; oral
2.0
6.5
77
390
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.7
6.5
127
767
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
6.5
246
1752
M79.1
ICD-10 Finland
Myalgia
1.7
6.5
137
848
G43.9
ICD-10 Finland
Migraine, unspecified
2.7
6.5
42
159
R20.2
ICD-10 Finland
Paraesthesia of skin
2.0
6.5
77
393
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
2.7
6.5
40
149
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
2.0
6.5
81
422
M01AB55
ATC
diclofenac, combinations; oral
1.9
6.5
89
480
A07EA06
ATC
budesonide; oral, local oral
2.7
6.5
42
160
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
6.4
89
481
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.4
6.4
285
2097
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
3.1
6.4
33
109
A97
ICPC
No disease
1.6
6.4
185
1240
R30.0
ICD-10 Finland
Dysuria
2.6
6.4
45
179
T90
ICPC
Diabetes non-insulin dependent
1.4
6.4
341
2600
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
2.6
6.4
43
169
R07.2
ICD-10 Finland
Precordial pain
3.1
6.3
32
105
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.2
6.3
62
292
F32.1
ICD-10 Finland
Moderate depressive episode
2.5
6.3
48
199
T08
ICPC
Weight loss
4.2
6.3
22
53
J01FA10
ATC
azithromycin; systemic
1.3
6.3
677
5758
D84
ICPC
Oesophagus disease
11.1
6.3
11
10
N06AB03
ATC
fluoxetine; oral
1.6
6.3
143
904
K25.1
ICD-10 Finland
Gastric ulcer, Acute with perforation
+∞
6.3
6
*
5301X
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[OESOPHAGITIS NUD]
+∞
6.3
6
*
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.4
6.2
294
2189
A06AC51
ATC
ispaghula, combinations; systemic
2.1
6.2
62
295
D14
ICPC
Haematemesis/vomiting blood
26.8
6.2
8
*
K29.2
ICD-10 Finland
Alcoholic gastritis
26.8
6.2
8
*
NF1AA
NOMESCO Finland
Hip X-ray examination
1.8
6.2
111
653
J01.4
ICD-10 Finland
Acute pansinusitis
7.1
6.2
14
20
R21
ICPC
Throat symptom/complaint
1.6
6.2
174
1159
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.8
6.2
96
539
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
6.2
105
608
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.2
6.2
61
289
M01AX17
ATC
nimesulide; oral
1.4
6.1
319
2417
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.5
6.1
44
178
WX004
NOMESCO Finland
Patient-controlled sedation
7.7
6.1
13
17
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
6.1
183
1236
WX882
NOMESCO Finland
High dependency care
2.6
6.1
40
154
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.1
6.1
67
331
L16
ICPC
Ankle symptom/complaint
1.7
6.1
118
713
R03AC12
ATC
salmeterol; inhalant
2.2
6.1
55
250
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
2.2
6.1
55
250
R03DC03
ATC
montelukast; oral
1.6
6.1
162
1067
Z98.8
ICD-10 Finland
Other specified postsurgical states
4.4
6.0
20
46
Z53.8
ICD-10 Finland
Procedure not carried out for other reasons
10.1
6.0
11
11
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
6.0
572
4770
K43.0
ICD-10 Finland
Incisional hernia with obstruction, without gangrene
5.2
6.0
17
33
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
2.1
6.0
65
321
H02AB04
ATC
methylprednisolone; systemic
1.6
6.0
169
1128
SPAT1104
SPAT
Monitoring of emergency patient
1.9
6.0
89
492
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
3.6
6.0
25
71

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1128
1334
22.43
307.65
2.1
1.2
—
—
—
0
0
745
3381
3.11
112.41
2.9
2.1
3.2
3.0
mg/l
1.31
654
2840
964
5214
2.92
103.13
3.7
2.6
118.7
170.5
ug/l
8.10
889
4757
823
4228
2.81
94.89
3.4
2.4
56.3
58.7
u/l
0.91
764
3885
1187
7428
2.91
92.06
6.9
6.5
11.4
12.0
umol/l
0.63
1143
7070
991
5917
2.58
79.84
2.5
1.9
97.0
94.4
pmol/l
0.87
554
3095
854
4795
2.54
77.82
6.2
5.7
—
—
—
0
0
481
2062
2.85
75.50
2.6
2.5
2.4
2.3
g/l
3.79
453
1923
1025
6334
2.52
74.94
10.5
10.2
1.3
1.3
inr
0.00
244
1805
1018
6315
2.49
73.12
6.4
4.8
34.5
35.3
g/l
3.96
959
5874
498
2222
2.74
71.93
2.7
2.5
11.1
13.1
umol/l
7.57
472
2071
1032
6488
2.46
71.26
6.7
6.0
59.1
57.8
%
2.94
962
6086
1486
11167
3.34
70.99
9.4
7.6
80.7
78.9
u/l
0.78
1417
10508
795
4469
2.44
70.23
3.3
2.4
—
—
—
0
0
1025
6482
2.43
68.97
7.3
6.4
8.8
9.0
%
1.06
967
6075
1038
6603
2.43
68.89
7.0
6.2
25.3
27.0
%
5.21
969
6153
1021
6453
2.42
68.68
6.8
6.1
3.0
2.9
%
0.60
964
6023
410
1699
2.85
67.79
2.1
2.5
1.7
1.7
%
0.02
343
1517
449
1955
2.75
67.49
2.7
2.5
19.0
23.3
%
7.24
373
1678
998
6280
2.39
67.29
6.8
6.1
0.7
0.7
%
0.30
941
5868
1412
10470
2.90
65.96
5.1
3.8
13.6
12.5
mm/h
1.77
1290
9669
646
3410
2.43
64.40
1.8
1.6
19.7
20.5
nmol/l
0.66
538
2873
369
1484
2.89
64.20
1.4
1.3
—
—
—
0
0
1243
8733
2.50
63.67
7.1
4.8
6.9
6.8
mmol/l
0.09
1187
8230
1085
7277
2.32
60.27
8.9
7.0
1.2
1.2
mmol/l
0.61
941
6109
1069
7175
2.28
58.55
6.9
6.0
0.2
0.2
e9/l
0.38
956
6202
1318
9677
2.52
58.53
5.5
4.1
—
—
—
0
0
1043
6936
2.27
58.34
6.4
5.8
0.0
0.0
e9/l
0.75
930
5907
1056
7066
2.27
58.07
6.5
5.9
1.8
1.9
e9/l
2.93
939
6122
1038
6908
2.26
57.69
6.4
5.8
0.6
0.6
e9/l
2.63
926
5875
529
2670
2.41
57.08
2.0
1.7
1027.0
1190.6
nmol/l
3.96
403
1987
1014
6751
2.21
55.38
5.1
3.9
—
—
—
0
0
1239
8952
2.35
55.35
4.8
3.0
62.3
55.0
u/l
1.23
1148
8260
209
661
3.46
54.29
2.7
2.4
—
—
—
0
0
999
6649
2.19
54.11
7.9
6.3
1.2
1.2
mmol/l
0.86
894
6006
319
1304
2.77
53.01
2.1
2.6
67.2
67.9
e9/l
0.12
249
983
876
5573
2.16
52.84
2.6
2.1
—
—
—
0
0
618
3465
2.22
50.99
3.1
2.3
—
—
—
0
0
339
1477
2.61
49.37
2.6
2.8
8.4
9.1
umol/l
0.19
306
1311
472
2414
2.31
48.21
1.3
1.2
2.2
1.8
u/ml
0.18
82
657
1132
8143
2.13
47.20
9.3
9.1
4.3
4.2
e9/l
0.46
1019
7033
1234
9190
2.20
46.81
5.7
4.2
145.9
1014.2
e6/l
0.97
16
146
863
5645
2.06
46.27
4.6
3.5
40.0
59.4
ng/l
0.67
652
4187
838
5454
2.04
45.23
2.6
2.2
75.5
77.5
nmol/l
1.16
725
4812
390
1926
2.32
42.61
5.6
6.1
1.0
1.0
mmol/l
0.08
363
1791
431
2238
2.23
41.65
1.4
1.5
2.9
2.6
g/l
1.05
234
1378
312
1413
2.47
41.31
4.5
4.3
—
—
—
0
0
695
4386
1.98
39.39
5.4
3.9
—
—
—
0
0
284
1263
2.49
38.95
2.4
2.3
129.7
174.9
ug/g
1.95
233
1005
1640
14267
3.87
38.87
24.0
14.3
24.5
26.5
mg/l
1.63
1448
11252
300
1393
2.40
37.32
2.6
2.0
0.2
0.2
g/l
0.14
280
1308
708
4558
1.94
37.32
3.3
3.0
1582.3
1410.7
ng/l
0.44
604
3928
608
3730
1.97
36.85
5.5
3.9
87.9
87.4
%
0.18
594
3653
222
909
2.65
35.99
3.9
3.7
5.2
5.1
kpa
0.34
204
835
664
4224
1.93
35.94
5.1
4.4
—
—
—
0
0
220
898
2.66
35.89
3.9
3.7
7.4
7.4
ph
0.47
21
121
1513
12764
2.48
35.13
5.2
4.3
1.9
2.1
mu/l
0.92
1353
11497
156
541
3.07
34.41
4.1
4.2
24.5
24.8
mmol/l
0.59
142
499
172
644
2.86
33.05
4.1
3.9
—
—
—
0
0
174
659
2.82
32.72
1.2
1.3
—
—
—
0
0
183
720
2.72
31.97
1.5
1.8
1.6
1.6
g/l
0.35
163
613
115
357
3.38
30.42
1.7
1.6
—
—
—
0
0
680
4558
1.81
29.77
2.4
2.1
357.2
250.7
u/l
0.40
642
4287
483
2915
1.91
29.53
5.3
3.7
493.0
796.9
ng/l
0.43
398
2417
1677
15206
4.36
28.84
28.3
17.0
139.3
139.7
mmol/l
8.98
1640
14837
202
885
2.45
28.18
11.7
10.8
—
—
—
0
0
419
2452
1.94
27.88
3.5
3.4
0.8
0.8
mmol/l
2.15
390
2294
1676
15256
4.16
27.26
28.5
17.1
4.0
4.0
mmol/l
0.16
1633
14868
496
3104
1.84
26.61
1.8
1.7
104177321.1
22451016.4
pmol/l
1.04
407
2530
111
367
3.16
26.48
1.3
1.3
—
16.7
—
0
9
301
1594
2.08
26.45
3.4
4.4
9.5
15.4
ug/l
0.57
242
1317
194
866
2.40
25.90
1.3
1.1
—
—
—
0
0
304
1630
2.05
25.78
1.4
1.3
703.2
482.5
titre
0.98
74
322
328
1808
2.00
25.76
9.9
7.9
0.7
1.0
mmol/l
0.71
272
1425
1250
10239
1.80
25.39
4.0
3.6
15.0
14.9
pmol/l
0.22
1117
9178
255
1287
2.15
25.36
3.9
2.3
31.0
41.3
u/l
1.37
214
1116
305
1650
2.03
25.20
10.2
8.2
95.6
95.7
%
0.05
294
1592
595
3988
1.75
25.01
3.5
3.1
—
—
—
0
0
472
2957
1.82
24.98
1.8
1.7
1.3
1.3
mg/l
0.06
367
2297
193
874
2.36
24.91
3.5
3.4
4.3
4.3
e9/l
0.01
127
666
1644
14899
3.08
24.80
23.8
13.5
—
—
—
0
0
323
1810
1.96
24.05
10.1
7.9
5.1
5.1
kpa
0.67
311
1740
322
1810
1.96
23.74
10.1
7.9
11.9
12.1
kpa
0.41
311
1737
1677
15451
3.79
22.99
14.8
10.5
26.5
27.4
u/l
1.06
1616
14853
451
2902
1.75
21.27
3.2
2.7
544.3
563.6
mosm/kgh2o
1.04
376
2479
276
1542
1.94
20.49
10.9
8.6
118.5
122.9
g/l
3.29
267
1484
352
2134
1.82
20.22
2.3
2.0
—
—
—
0
0
703
5140
1.62
20.12
4.2
4.0
12.8
8.2
mg/mmol
0.79
469
3320
1544
13828
2.08
20.04
7.6
6.0
40.7
40.4
mmol/mol
0.71
1404
12721
516
3498
1.68
19.88
6.9
6.9
—
—
—
0
0
1449
12724
1.85
19.67
27.5
15.8
38.8
40.1
%
5.05
935
8685
716
5285
1.61
19.54
3.7
3.2
—
5.9
—
0
7
688
5030
1.61
19.54
3.4
3.1
7.4
7.9
mmol/l
2.66
556
4231
1700
15955
4.78
19.46
35.9
21.2
6.9
6.8
e9/l
1.19
1666
15444
1699
15946
4.65
19.30
35.9
21.2
249.5
241.2
e9/l
5.18
1667
15490
1699
15949
4.64
19.23
35.8
21.1
90.9
91.5
fl
5.88
1677
15692
1699
15949
4.64
19.23
35.7
21.1
30.1
30.5
pg
12.19
1677
15690
1699
15951
4.64
19.19
35.9
21.1
4.4
4.5
e12/l
10.58
1663
15445
1699
15955
4.62
19.09
36.1
21.3
132.0
137.3
g/l
32.68
1678
15698
1579
14328
2.17
18.70
6.0
4.7
6.1
6.1
mmol/l
1.43
1432
12945
168
809
2.19
18.61
11.2
10.9
24.1
24.4
mmol/l
0.43
162
759
888
6945
1.57
18.60
4.1
3.5
0.0
0.0
estimate
0.80
115
1268
96
359
2.77
18.39
1.7
1.4
294.9
272.6
ug/g
0.48
58
218
216
1150
2.00
18.33
2.1
2.4
384.0
372.4
nmol/l
0.32
195
1059
657
4807
1.59
18.27
3.1
3.5
2.3
2.4
mmol/l
1.78
530
4189
876
6861
1.56
18.01
5.8
4.6
0.0
0.0
estimate
0.00
123
1339
278
1620
1.85
17.99
1.9
1.8
—
—
—
0
0
233
1282
1.94
17.97
2.5
2.8
65.1
66.2
g/l
1.15
210
1172
376
2408
1.72
17.61
2.0
2.1
29.9
30.0
s
0.08
358
2337
87
316
2.85
17.61
3.4
2.4
32.9
37.1
umol/l
0.55
75
267
246
1390
1.90
17.50
6.8
7.5
10.7
10.2
mmol/l
0.49
235
1315
372
2391
1.71
17.14
3.7
3.0
2.2
1.7
e6/l
0.49
233
1291
660
4891
1.56
17.06
3.6
3.2
1110.1
262.0
mg/l
2.07
425
3186
441
2971
1.65
16.97
4.2
3.8
1.0
1.0
kg/l
0.81
103
401
868
6855
1.53
16.70
4.1
3.5
0.0
0.0
estimate
0.00
113
1309
199
1065
1.98
16.59
2.2
2.6
—
—
—
0
0
226
1286
1.87
15.65
1.4
1.5
—
—
—
0
0
138
658
2.19
15.63
8.1
5.2
0.9
0.9
%
0.20
130
619
319
2014
1.72
15.55
9.0
7.2
104.5
104.4
mmol/l
0.09
312
1962
92
368
2.58
15.46
10.5
6.8
104.4
105.3
mmol/l
0.73
86
330
92
368
2.58
15.46
10.5
6.8
11.3
11.3
mmol/l
0.02
86
330
112
494
2.35
15.26
10.0
6.2
1.2
1.3
mmol/l
0.65
101
439
609
4519
1.54
15.22
4.4
3.2
42.2
84.9
e6/l
2.13
493
3511
275
1682
1.75
14.97
1.5
1.4
—
—
—
0
0
553
4029
1.55
14.97
3.0
2.8
4152.9
5312.1
umol/l
0.26
467
3495
188
1029
1.93
14.63
4.0
4.1
102.3
95.2
ng/l
0.32
165
889
1602
14830
2.08
14.58
5.9
5.2
2.6
2.7
mmol/l
5.13
1440
13559
223
1295
1.83
14.43
11.1
9.2
—
—
—
0
0
136
666
2.13
14.40
8.2
5.1
1.7
1.7
%
0.59
128
627
230
1350
1.81
14.37
9.4
7.8
1.4
1.4
mmol/l
0.14
224
1307
189
1043
1.91
14.34
1.5
1.4
—
—
—
0
0
1577
14536
1.96
14.27
5.2
4.6
4.4
4.6
mmol/l
6.33
1432
13365
221
1287
1.82
14.16
1.6
1.5
—
—
—
0
0
116
537
2.24
14.13
2.9
3.9
40.4
61.5
mg/l
0.74
102
437
258
1576
1.75
14.06
1.5
1.5
—
—
—
0
0
214
1237
1.83
14.04
1.5
1.6
—
—
—
0
0
116
539
2.23
14.00
2.9
3.9
56.8
53.9
mg/l
0.13
103
437
584
4358
1.51
13.93
4.5
4.2
7.4
7.4
ph
1.57
78
868
327
2138
1.65
13.83
1.3
1.2
31.7
40.0
iu/ml
0.48
105
667
137
689
2.07
13.53
2.7
2.8
—
—
—
0
0
234
1422
1.75
12.94
4.8
3.7
1.7
2.0
mmol/l
0.55
190
1140
180
1021
1.85
12.52
2.6
2.8
10.4
10.4
g/l
0.01
165
932
184
1056
1.83
12.32
7.2
4.7
—
—
—
0
0
103
481
2.21
12.30
2.9
3.2
0.5
0.3
g/l
1.44
40
211
303
2004
1.62
12.12
26.1
26.1
1.5
1.4
inr
0.82
37
276
661
5164
1.45
12.11
5.1
3.6
122.8
99.2
e6/l
0.18
514
3761
1557
14427
1.79
11.94
5.4
4.6
1.4
1.4
mmol/l
3.84
1402
13170
147
794
1.93
11.87
1.5
1.9
1.2
1.4
g/l
0.28
133
722
47
151
3.17
11.85
1.4
1.2
—
—
—
0
0
369
2574
1.55
11.72
3.6
2.8
0.9
1.0
e6/l
0.28
227
1467
61
229
2.72
11.67
1.8
1.4
—
—
—
0
0
229
1424
1.70
11.60
4.8
3.6
5.7
5.9
kpa
2.16
222
1378
62
236
2.69
11.56
1.6
1.2
—
—
—
0
0
110
542
2.10
11.48
3.0
3.5
145.8
2639.3
u/ml
0.76
94
469
1513
13941
1.68
11.42
4.7
4.1
1.3
1.3
mmol/l
0.70
1369
12636
131
691
1.97
11.34
1.4
1.3
377.5
242.2
u/ml
0.51
116
636
61
236
2.64
11.03
1.5
1.3
60.2
60.6
mmol/l
0.03
49
193
52
185
2.87
11.01
1.6
1.5
0.8
0.9
g/l
0.27
38
136
86
392
2.26
10.91
2.8
4.2
—
—
—
0
0
28
68
4.17
10.63
14.0
16.5
—
—
—
0
0
48
168
2.91
10.48
2.9
2.4
—
—
—
0
0
108
553
2.02
10.18
2.3
2.7
10.6
10.3
g/l
0.34
81
477
521
4002
1.43
10.03
4.1
3.1
—
—
—
0
0
423
3128
1.47
9.96
3.1
2.5
3.7
4.5
e6/l
0.92
371
2768
81
375
2.22
9.92
1.6
1.4
0.2
0.2
g/l
0.36
72
359
205
1300
1.65
9.59
1.3
1.4
—
—
—
0
0
211
1358
1.63
9.31
3.5
2.8
182.5
200.4
ng/l
0.36
199
1249
167
1014
1.72
9.19
9.2
6.9
24.6
24.5
mmol/l
0.06
157
950
75
351
2.19
8.97
2.3
3.3
341.1
1198.0
u/ml
0.58
69
325
70
320
2.24
8.86
1.2
1.2
89.0
101.2
titre
—
10
25
80
387
2.12
8.81
1.7
1.4
1.2
1.2
g/l
0.36
71
369
26
69
3.81
8.79
1.4
1.2
135.6
138.1
nmol/l
0.07
26
69
165
1018
1.69
8.57
11.6
9.9
94.4
94.0
%
0.62
165
1012
527
4148
1.39
8.56
4.3
3.1
0.4
0.5
e6/l
0.14
417
3153
78
378
2.11
8.55
3.1
2.9
25.7
24.8
mmol/l
1.13
70
322
120
677
1.83
8.50
1.3
1.3
—
—
—
0
0
31
95
3.30
8.50
1.2
1.2
336.6
366.1
nmol/l
0.28
24
76
20
45
4.48
8.37
1.3
1.4
60.6
68.5
umol/l
—
7
25
108
594
1.87
8.29
2.2
1.7
—
—
—
0
0
27
77
3.55
8.26
1.3
1.4
1.6
1.1
nmol/l
0.59
20
58
873
7494
1.33
7.88
5.6
4.9
2.5
3.4
ug/l
0.56
768
6735
41
155
2.69
7.83
1.3
1.1
—
—
—
0
0
27
80
3.41
7.81
3.8
2.6
—
—
—
0
0
286
2050
1.47
7.72
1.3
1.2
9.4
12.4
u/ml
0.23
79
795
114
655
1.79
7.62
2.6
2.0
2.1
2.8
ug/l
0.29
101
580
66
315
2.14
7.56
1.4
1.2
3.4
2.9
u/ml
—
10
23
421
3269
1.38
7.24
3.6
3.4
—
—
—
0
0
176
1154
1.58
7.17
3.8
2.9
4.6
4.5
kpa
0.18
170
1115
25
76
3.32
6.97
1.1
1.1
—
—
—
0
0
460
3641
1.36
6.97
4.0
3.2
—
—
—
0
0
122
734
1.71
6.97
5.1
4.1
23.5
24.2
mmol/l
1.30
114
659
69
350
2.01
6.76
3.8
3.0
—
—
—
0
0
35
132
2.69
6.75
1.1
1.2
—
—
nmol/l
—
0
0
38
152
2.53
6.54
1.4
1.2
108.0
55.4
u/ml
—
6
5
64
322
2.03
6.43
2.2
2.1
130.0
129.9
g/l
0.01
42
232
71
376
1.93
6.18
4.3
4.1
—
—
—
0
0
17
43
3.98
6.17
1.2
1.9
—
—
—
0
0
23
72
3.22
6.15
1.1
1.0
—
—
—
0
0
103
616
1.71
6.04
1.2
1.2
—
—
—
0
0
479
3884
1.32
6.04
1.3
1.3
—
—
—
0
0
43
190
2.30
5.99
2.2
2.3
499.8
291.5
u/ml
0.17
43
182
261
1930
1.41
5.90
1.5
1.3
—
—
—
0
0
41
179
2.32
5.88
1.2
1.6
57.3
62.3
%
0.33
29
106
29
107
2.74
5.87
1.5
1.2
7.5
7.3
g/l
0.09
21
66
29
107
2.74
5.87
1.5
1.2
3.2
3.0
g/l
0.23
20
67
29
107
2.74
5.87
1.5
1.2
0.5
0.4
g/l
0.36
21
67
62
320
1.97
5.83
1.1
1.2
—
—
—
0
0
29
108
2.71
5.77
1.5
1.2
—
—
—
0
0
25
86
2.93
5.74
2.3
1.5
—
—
—
0
0
114
712
1.64
5.70
2.9
2.5
1.3
1.2
%
0.12
114
707
30
115
2.64
5.65
1.3
1.3
11.2
13.5
u/l
0.43
25
107
34
139
2.48
5.63
1.2
1.3
275.5
277.0
mosm/kgh2o
0.12
28
100
46
215
2.17
5.63
1.1
1.2
—
—
—
0
0
69
374
1.88
5.63
1.6
1.6
6616.7
15410.0
e6/l
2.08
51
262
75
421
1.82
5.49
3.6
3.4
—
—
—
0
0
83
481
1.76
5.46
2.0
2.6
36.4
37.5
g/l
0.93
70
418
34
142
2.42
5.39
3.3
1.8
—
—
—
0
0
133
877
1.56
5.32
3.7
2.9
—
—
—
0
0
51
257
2.01
5.16
1.3
1.4
—
—
—
0
0
39
177
2.23
5.15
1.1
1.1
1.6
1.5
g/l
0.25
34
161
123
810
1.56
4.97
1.3
1.4
—
—
—
0
0
33
142
2.35
4.93
2.5
3.1
31.8
22.9
mg/l
0.23
23
109
13
32
4.09
4.90
1.4
1.1
247.0
265.1
pmol/l
—
8
21
199
1455
1.42
4.78
2.7
2.2
12.9
13.1
nmol/l
0.18
168
1277
37
170
2.20
4.76
2.5
2.4
—
—
—
0
0
421
5049
0.78
4.62
3.3
3.0
—
—
—
0
0
23
86
2.70
4.59
2.1
1.8
6.9
7.3
mmol/l
0.20
15
51
196
1443
1.40
4.53
1.6
1.5
—
—
—
0
0
22
81
2.74
4.52
1.7
3.0
7.4
7.4
ph
—
5
31
32
142
2.28
4.49
1.2
1.1
—
—
—
0
0
12
30
4.02
4.44
1.5
2.8
—
—
—
0
0
33
151
2.21
4.32
1.4
1.2
—
—
—
0
0
40
198
2.04
4.30
2.1
1.3
—
—
—
0
0
44
227
1.96
4.23
1.2
1.4
96.9
130.4
u/ml
—
10
35
23
90
2.58
4.22
2.0
1.5
—
—
—
0
0
13
36
3.63
4.20
1.5
1.5
—
—
—
0
0
34
160
2.15
4.17
1.1
1.3
0.2
0.3
nmol/l
—
5
16
59
337
1.78
4.15
1.6
1.7
—
—
—
0
0
50
272
1.86
4.12
1.4
1.6
—
—
—
0
0
29
129
2.27
4.07
2.8
1.9
—
—
—
0
0
14
42
3.35
4.04
1.2
1.2
4.4
186.8
ug/l
—
7
20
24
99
2.44
3.97
2.1
1.4
1837.2
1880.2
ml
—
6
16
477
4045
1.25
3.97
1.7
1.7
1.4
1.4
mmol/l
0.75
406
3335
64
380
1.71
3.95
1.6
2.1
11.4
11.9
mg/l
0.16
56
351
58
335
1.76
3.95
3.2
3.3
7.8
7.9
kpa
0.21
53
303
41
212
1.96
3.93
1.4
1.5
29.4
32.8
g/l
0.93
35
192
13
38
3.44
3.90
1.8
2.3
—
—
—
0
0
10
24
4.19
3.89
1.1
1.5
—
—
—
0
0
50
278
1.82
3.86
3.2
2.7
—
—
—
0
0
106
718
1.51
3.82
4.3
3.2
—
—
—
0
0
55
316
1.76
3.82
1.9
1.4
0.9
0.8
nmol/l
0.18
45
263
15
49
3.08
3.81
2.7
2.1
—
—
—
0
0
68
416
1.66
3.78
1.1
1.1
—
—
—
0
0
41
217
1.91
3.69
2.1
1.3
—
—
—
0
0
31
149
2.10
3.64
1.0
1.3
—
—
—
0
0
24
104
2.33
3.60
1.6
1.2
—
—
—
0
0
26
117
2.24
3.58
1.2
1.1
—
—
—
0
0
8
13
6.18
3.50
1.8
1.2
—
—
mmol/l
—
0
0
8
13
6.18
3.50
1.1
1.3
—
—
—
0
0
40
215
1.88
3.46
2.1
1.3
—
—
—
0
0
100
685
1.49
3.44
3.3
3.5
4.6
4.4
pmol/l
1.07
87
601
13
42
3.11
3.37
1.9
2.3
—
—
—
0
0
38
203
1.89
3.36
2.3
2.3
—
—
—
0
0
15
53
2.85
3.36
38.9
33.0
7.7
7.2
ug/l
0.44
15
47
166
1254
1.36
3.32
3.6
4.0
1.1
0.9
%
0.37
41
382
30
148
2.05
3.31
1.8
1.3
238838.8
83386.6
e6/l
0.30
16
96
32
162
1.99
3.30
1.5
1.6
—
—
—
0
0
47
272
1.75
3.23
2.0
1.8
6.4
4.7
iu/l
0.27
20
82
39
214
1.84
3.19
2.1
1.3
—
—
—
0
0
41
229
1.81
3.17
1.1
1.2
360.2
289.2
u/ml
0.51
22
136
29
145
2.02
3.11
3.4
3.5
—
—
—
0
0
39
217
1.82
3.07
2.1
1.3
—
—
—
0
0
31
160
1.95
3.05
1.4
1.5
—
—
—
0
0
26
126
2.08
3.03
1.7
1.5
—
—
—
0
0
177
1371
1.32
3.01
2.0
2.3
6.9
8.2
ug/l
0.46
146
1224
22
100
2.22
3.00
1.9
1.6
—
—
—
0
0
1147
10771
1.19
2.99
4.7
4.0
—
—
—
0
0
14
51
2.76
2.98
1.9
1.7
—
—
—
0
0
713
6432
1.18
2.98
11.7
9.8
0.0
0.0
e9/l
0.78
596
5277
35
190
1.86
2.98
1.5
1.4
3300.4
2049.8
e6/l
0.34
26
136
33
176
1.89
2.96
1.1
1.5
—
—
—
0
0
52
322
1.63
2.83
3.6
3.7
—
—
—
0
0
38
217
1.77
2.77
2.3
2.4
—
—
—
0
0
10
31
3.24
2.77
1.1
1.0
—
—
—
0
0
32
175
1.84
2.69
1.7
1.5
—
—
—
0
0
32
175
1.84
2.69
1.7
1.5
—
—
—
0
0
32
175
1.84
2.69
1.7
1.5
—
—
—
0
0
32
175
1.84
2.69
1.7
1.5
—
—
—
0
0
30
161
1.88
2.67
1.3
1.4
5.7
6.5
mmol/l
1.56
25
152
57
367
1.57
2.67
1.2
1.1
—
—
—
0
0
30
163
1.86
2.58
2.3
1.3
—
—
—
0
0
43
261
1.66
2.55
1.7
1.4
—
—
—
0
0
31
171
1.83
2.55
1.5
1.4
59661.2
108137.7
e6/l
0.35
21
107
322
2740
1.22
2.51
2.9
3.2
2.5
2.5
mmol/l
0.02
275
2442
18
83
2.18
2.41
1.1
1.7
—
—
—
0
0
19
90
2.12
2.39
3.2
3.9
—
—
—
0
0
20
97
2.07
2.37
1.3
1.2
102.5
75.5
titre
—
8
20
32
183
1.76
2.36
2.1
2.3
—
—
—
0
0
8
22
3.65
2.36
1.8
1.1
—
—
—
0
0
42
261
1.62
2.31
1.2
1.2
—
—
—
0
0
10
35
2.87
2.30
1.1
1.1
—
—
—
0
0
36
215
1.69
2.30
1.1
1.3
72.7
173.4
miu/ml
—
6
86
30
171
1.77
2.25
2.8
3.8
—
—
—
0
0
18
86
2.10
2.23
1.1
1.1
—
—
—
0
0
9
29
3.11
2.22
5.0
8.2
—
—
—
0
0
151
1197
1.29
2.22
3.7
4.1
0.1
0.1
%
0.11
36
353
10
36
2.79
2.20
1.3
1.4
—
—
—
0
0
53
353
1.52
2.19
1.0
1.1
—
—
—
0
0
8
24
3.34
2.18
1.9
1.4
—
—
—
0
0
23
122
1.90
2.16
1.5
2.5
0.8
1.0
e9/l
—
9
67
8
25
3.21
2.09
1.9
1.6
—
—
—
0
0
144
1146
1.28
2.07
3.4
3.9
0.9
0.6
%
0.40
28
275
10
38
2.64
2.01
4.7
8.2
—
—
—
0
0
9
32
2.82
2.00
1.6
1.4
—
—
—
0
0
48
321
1.51
1.97
1.3
1.1
—
—
—
0
0
39
249
1.58
1.96
1.3
1.4
30.0
29.3
iu/l
0.04
31
210
12
51
2.36
1.95
1.8
2.7
—
—
—
0
0
46
306
1.52
1.94
1.6
1.4
6.9
8.5
u/l
0.67
35
252
429
3826
1.16
1.93
4.4
3.8
0.0
0.0
estimate
0.38
116
1255
6
16
3.76
1.93
1.7
1.7
—
—
—
0
0
10
39
2.57
1.92
1.7
2.4
—
—
—
0
0
28
458
0.60
1.91
1.2
1.7
—
—
—
0
0
12
52
2.32
1.88
1.9
2.7
369.8
682.8
e6/l
—
6
41
55
384
1.45
1.85
2.7
3.2
1.8
1.6
mg/l
0.86
46
347
341
2998
1.17
1.84
4.8
4.5
—
—
—
0
0
48
327
1.48
1.82
3.0
3.1
0.7
0.8
nmol/l
0.94
37
252
17
87
1.96
1.80
1.0
1.1
—
—
—
0
0
139
1123
1.26
1.80
3.7
4.1
0.1
0.1
%
0.13
32
294
37
239
1.56
1.79
2.1
3.5
—
—
—
0
0
25
148
1.70
1.70
2.6
1.8
11.6
11.3
%
0.14
25
148
17
90
1.90
1.65
1.4
1.3
0.1
0.7
u/ml
0.79
11
48
25
151
1.67
1.60
1.5
1.2
—
—
—
0
0
7
26
2.70
1.58
1.0
1.2
—
—
—
0
0
41
280
1.48
1.57
1.2
1.4
—
—
—
0
0
31
199
1.57
1.57
1.1
1.1
—
—
—
0
0
1233
11882
1.13
1.55
32.2
18.9
330.9
333.1
g/l
12.82
1227
11795
15
78
1.93
1.54
3.1
2.4
—
—
—
0
0
80
1028
0.77
1.53
1.3
1.4
—
—
—
0
0
47
332
1.43
1.53
3.0
2.5
16.4
16.1
%
0.23
30
164
50
686
0.72
1.50
1.3
1.5
—
—
—
0
0
12
58
2.08
1.49
3.3
2.9
—
—
—
0
0
23
139
1.66
1.48
1.1
1.5
—
—
—
0
0
9
37
2.44
1.48
1.1
1.2
—
9.6
%
—
0
5
10
45
2.23
1.46
1.1
1.3
—
—
—
0
0
26
164
1.59
1.43
1.4
1.4
—
—
—
0
0
30
198
1.52
1.38
1.0
1.1
—
—
—
0
0
6
23
2.61
1.37
1.0
1.0
—
—
—
0
0
83
659
1.27
1.30
1.2
1.2
198.5
141.1
iu/ml
0.27
25
240
18
106
1.71
1.29
1.4
2.4
622.0
629.8
e6/l
0.02
12
43
1225
11854
1.11
1.27
31.6
17.7
14.2
13.7
%
19.44
1210
11561
32
220
1.46
1.24
1.1
1.1
1.2
98.1
iu/ml
—
5
45
48
357
1.35
1.21
1.2
1.3
539.6
560.6
mg/l
0.12
43
330
44
323
1.37
1.20
1.2
1.2
3.7
3.8
mmol/l
0.52
39
299
12
64
1.88
1.18
3.3
2.8
—
—
—
0
0
28
190
1.48
1.16
1.2
1.2
—
—
—
0
0
0
34
0.00
1.16
0.0
1.3
—
—
—
0
0
0
34
0.00
1.16
0.0
1.3
—
—
—
0
0
0
35
0.00
1.15
0.0
1.4
—
—
—
0
0
19
119
1.60
1.11
1.1
1.2
—
—
—
0
0
10
52
1.93
1.06
2.2
2.5
—
—
—
0
0
19
121
1.58
1.05
2.2
2.3
—
—
—
0
0
5
106
0.47
1.01
2.2
5.9
—
38.0
—
0
31
67
539
1.25
0.99
1.6
2.1
23.0
21.9
s
0.24
59
485
23
156
1.48
0.98
1.2
1.1
0.4
2.0
u/ml
—
9
61
0
30
0.00
0.97
0.0
6.3
—
—
—
0
0
9
50
1.80
0.96
1.1
1.3
—
—
—
0
0
11
62
1.78
0.94
1.2
1.0
—
—
—
0
0
16
101
1.59
0.93
1.3
1.3
20.6
34.3
u/l
—
9
78
61
491
1.25
0.92
3.7
4.0
4.0
3.9
mmol/l
0.47
55
461
10
56
1.79
0.88
1.1
1.1
—
—
—
0
0
14
87
1.61
0.87
1.4
2.4
13.6
12.5
%
—
5
31
64
523
1.23
0.86
1.3
1.4
—
—
—
0
0
36
273
1.33
0.86
2.1
1.2
48.1
39.1
u/l
0.17
27
232
8
44
1.82
0.86
2.5
5.0
—
—
—
0
0
17
113
1.51
0.82
1.3
2.0
2.0
1.6
u/field
—
10
42
6
32
1.88
0.82
2.7
2.8
3.8
6.3
mg/l
—
6
27
19
131
1.46
0.78
2.3
2.2
635.0
615.5
ml
0.06
13
82
23
165
1.40
0.78
1.1
1.1
—
—
—
0
0
9
53
1.70
0.75
1.3
2.3
—
—
—
0
0
48
388
1.24
0.73
4.7
4.5
7.4
7.4
ph
2.25
39
330
7
38
1.85
0.73
1.7
1.5
—
—
—
0
0
21
150
1.40
0.73
2.0
1.4
37.8
27.5
%
0.66
12
91
20
142
1.41
0.72
1.1
1.0
0.2
4.9
u/ml
—
8
61
9
56
1.61
0.72
1.2
1.3
—
—
—
0
0
38
301
1.27
0.69
2.9
2.0
—
—
—
0
0
7
43
1.63
0.67
1.0
1.0
1593.6
1234.2
miu/ml
—
7
43
25
188
1.33
0.66
1.2
1.3
—
—
—
0
0
39
483
0.80
0.66
1.2
1.2
—
—
—
0
0
41
335
1.23
0.60
4.9
4.7
2.2
2.6
mmol/l
0.42
28
225
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
13
89
1.46
0.58
1.5
1.1
—
—
—
0
0
17
123
1.39
0.58
1.2
1.1
—
—
—
0
0
52
438
1.19
0.57
1.7
1.6
—
—
—
0
0
14
98
1.43
0.56
1.3
1.4
—
—
—
0
0
6
37
1.62
0.55
1.0
1.1
—
—
—
0
0
6
38
1.58
0.54
1.0
1.2
—
—
—
0
0
49
415
1.19
0.52
2.8
2.3
205.0
79.2
ug/min
0.63
28
252
109
1209
0.89
0.52
5.0
3.8
—
—
—
0
0
6
40
1.50
0.51
1.3
1.4
—
—
—
0
0
15
109
1.38
0.51
1.1
1.0
0.9
3.0
u/ml
—
9
39
10
67
1.50
0.49
1.6
1.1
—
—
—
0
0
33
274
1.21
0.45
1.1
1.5
—
—
—
0
0
5
31
1.61
0.43
1.2
3.1
—
—
—
0
0
8
56
1.43
0.42
1.4
1.1
—
—
—
0
0
136
1256
1.09
0.41
2.9
3.3
—
—
—
0
0
0
16
0.00
0.41
0.0
8.6
—
0.3
—
0
16
455
4382
1.05
0.41
3.4
3.0
0.7
0.8
ug/l
0.08
313
2906
9
68
1.33
0.37
1.1
3.0
1039.7
1402.4
u/ml
—
9
68
22
179
1.23
0.37
1.3
1.1
—
13.0
—
0
11
61
549
1.12
0.33
1.1
1.1
—
—
—
0
0
38
332
1.15
0.32
2.9
3.4
18.0
27.8
mg/l
1.65
22
208
19
156
1.22
0.31
1.1
1.1
—
—
—
0
0
16
196
0.81
0.30
3.3
3.9
15.3
30.5
u/ml
1.77
16
191
30
259
1.16
0.30
3.2
3.2
4.1
4.3
e9/l
0.23
30
259
19
157
1.21
0.29
1.1
1.1
—
—
—
0
0
17
139
1.23
0.29
1.1
1.0
0.3
1.2
u/ml
—
6
50
24
204
1.18
0.28
1.2
1.1
3.7
4.5
u/ml
0.23
14
86
21
177
1.19
0.27
1.3
1.4
41.6
47.7
mu/l
0.09
21
153
17
140
1.22
0.27
2.2
2.3
—
—
—
0
0
35
310
1.13
0.26
1.2
1.5
171.5
871.2
e6/l
0.92
28
245
35
310
1.13
0.26
1.2
1.4
2.7
35.7
e6/l
1.00
25
235
9
72
1.25
0.25
1.3
1.8
—
—
—
0
0
118
1251
0.94
0.25
4.3
4.0
1.2
1.2
mmol/l
1.58
110
1091
18
152
1.19
0.23
1.5
1.2
—
—
—
0
0
29
256
1.14
0.23
1.1
1.3
—
—
—
0
0
10
124
0.81
0.21
2.5
3.0
13.5
13.2
%
—
10
124
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
11
89
1.24
0.21
1.3
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.9
—
—
—
0
0
6
52
1.15
0.19
1.3
1.0
—
—
—
0
0
30
270
1.11
0.19
3.2
3.5
60.4
58.0
%
0.60
30
270
12
101
1.19
0.16
1.2
1.1
1.7
3.0
u/ml
—
5
35
9
81
1.11
0.15
2.0
2.7
—
—
—
0
0
17
155
1.10
0.09
1.4
1.2
—
—
—
0
0
7
80
0.87
0.07
1.9
2.8
1985.7
1922.1
ml
—
7
68
7
85
0.82
0.07
1.7
2.6
—
—
—
0
0
77
749
1.03
0.06
1.3
1.3
—
—
—
0
0
15
138
1.09
0.06
1.3
1.6
—
—
—
0
0
10
90
1.11
0.05
1.3
1.7
—
—
—
0
0
51
497
1.03
0.04
13.4
10.5
—
—
—
0
0
63
640
0.98
0.02
4.8
4.4
—
—
—
0
0
13
137
0.95
0.01
1.4
1.5
67.0
275.2
pmol/l
—
7
45
10
98
1.02
0.00
1.1
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
0.00
1.4
1.4
—
76.1
—
0
9
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
96.4
—
0
7
9
93
0.97
0.00
3.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_BARRET and mortality.

Females

Parameter HR [95% CI] p-value
K11_BARRET 1.414 [1.09, 1.83] 0.008
Birth year 0.992 [0.98, 1.0] 0.077

During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 2231 females with K11_BARRET died.

Males

Parameter HR [95% CI] p-value
K11_BARRET 1.55 [1.25, 1.92] < 0.001
Birth year 0.99 [0.98, 1.0] 0.039

During the follow-up period (1.1.1998 — 31.12.2019), 580 out of 4061 males with K11_BARRET died.

Mortality risk

Mortality risk for people of age

years, who have K11_BARRET.

N-year risk Females Males
1 0.123% 0.313%
5 0.75% 1.877%
10 1.949% 5.046%
15 3.682% 9.446%
20 6.433% 16.279%

Relationships between endpoints

Index endpoint: K11_BARRET – Barrett oesophagus

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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