Other and unspecified psoriasis

L12_PSORI_NAS

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L40.8, L40.9
  • Hospital discharge: ICD-9 6968X
  • Hospital discharge: ICD-8 69619
  • Cause of death: ICD-10 L40.8, L40.9
  • Cause of death: ICD-9 6968X
  • Cause of death: ICD-8 69619

2 out of 7 registries used, show all original rules.

2533

4. Check minimum number of events

None

2533

5. Include endpoints

None

2533

6. Filter based on genotype QC (FinnGen only)

2533

Control definitions (FinnGen only)

Control exclude
L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17507 7898 9423
Only index persons 14685 6954 7731
Unadjusted period prevalence (%)
Whole population 0.25 0.23 0.26
Only index persons 0.28 0.26 0.30
Median age at first event (years)
Whole population 50.61 51.59 49.78
Only index persons 49.46 50.13 48.86

-FinnGen-

Key figures

All Female Male
Number of individuals 2533 1252 1281
Unadjusted period prevalence (%) 0.50 0.43 0.56
Median age at first event (years) 51.33 49.95 52.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2249
Matched controls
22492
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L40.9
ICD-10 Finland
Psoriasis, unspecified
921.9
323.0
1194
28
69619
ICD-8 Finland
Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)
+∞
323.0
530
*
D05AX02
ATC
calcipotriol; topical
115.7
323.0
1069
175
E0000UV
ATC
NA
7.5
323.0
1622
5757
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
13.6
323.0
809
890
L40
ICD-10 Finland
Psoriasis
84.1
323.0
373
53
D05AX52
ATC
calcipotriol, combinations; topical
92.4
323.0
1205
277
E000001
ATC
NA
7.5
323.0
1094
2509
L40.5
ICD-10 Finland
Arthropathic psoriasis
1156.0
323.0
461
5
D07AC01
ATC
betamethasone; topical
9.1
323.0
1596
4778
D05AX03
ATC
calcitriol; topical
118.5
323.0
400
41
L40.0
ICD-10 Finland
Psoriasis vulgaris
462.1
323.0
1232
58
D07AD01
ATC
clobetasol; topical
11.3
323.0
1055
1632
D05BB02
ATC
acitretin; oral
146.5
323.0
586
54
D07XC01
ATC
betamethasone, combinations; topical
24.1
323.0
1301
1213
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
1142.8
323.0
527
6
L40.8
ICD-10 Finland
Other psoriasis
1926.0
323.0
765
6
D07AC13
ATC
mometasone; topical
4.9
257.4
1176
4078
319
Kela drug reimbursment
Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)
+∞
230.2
217
*
D07AB02
ATC
hydrocortisone butyrate; topical
4.5
223.2
1091
3884
M07.3
ICD-10 Finland
Other psoriatic arthropathies
223.7
217.7
222
11
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
6.2
191.6
589
1221
E000002
ATC
NA
6.0
185.1
583
1240
S91
ICPC
Psoriasis
150.6
183.6
193
14
E000003
ATC
NA
11.0
171.7
346
366
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
11.6
169.4
332
332
134
Kela drug reimbursment
General erythroderma
349.8
164.3
164
5
6961A
ICD-9 Finland
Psoriasis and similar disorders, Other psoriasis[PSORIASIS VULGARIS]
+∞
160.3
152
*
D07AB08
ATC
desonide; topical
5.4
151.4
512
1157
D05AA
ATC
Tars
83.9
139.4
156
20
L04AB04
ATC
adalimumab; parenteral
19.7
132.1
204
113
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
31.5
116.5
156
53
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
3.1
111.2
783
3277
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
6.1
111.1
329
616
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.7
109.7
417
1038
A07EC01
ATC
sulfasalazine; oral, rectal
5.1
109.5
379
853
D02AE01
ATC
carbamide; topical
5.8
109.0
338
669
L40.4
ICD-10 Finland
Guttate psoriasis
272.8
102.7
104
*
TQW80
NOMESCO Finland
Local dermatologic skincare
11.2
100.0
196
190
L40.3
ICD-10 Finland
Pustulosis palmaris et plantaris
32.7
95.9
127
41
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.0
89.3
313
705
M07.0*L40.5
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
892.3
88.3
86
*
L04AC05
ATC
ustekinumab; parenteral
100.3
87.7
96
10
L04AC10
ATC
secukinumab; parenteral
121.2
86.6
93
8
E000006
ATC
NA
4.9
85.6
302
684
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
10.1
84.1
174
186
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
9.5
84.0
179
202
377
Kela drug reimbursment
Apremilast and dimethyl fumarate (psoriasis)
+∞
79.6
76
*
6960A
ICD-9 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
78.6
75
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.0
77.9
547
2194
H02AB06
ATC
prednisolone; systemic
2.3
72.6
1180
7400
L04AB01
ATC
etanercept; parenteral
15.1
70.2
119
83
L04AC13
ATC
ixekizumab; parenteral
+∞
65.9
63
*
L04AA32
ATC
apremilast; oral
+∞
62.8
60
*
69600
ICD-8 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
59.6
57
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
57.2
1078
6938
E000007
ATC
NA
4.6
57.2
211
493
D07AA02
ATC
hydrocortisone; topical
2.8
55.6
399
1587
D07XB01
ATC
flumetasone, combinations; topical
22.1
53.8
79
37
D07BC01
ATC
betamethasone and antiseptics; topical
2.9
53.4
372
1445
L04AD01
ATC
ciclosporin; systemic
8.6
52.7
118
144
L04AA13
ATC
leflunomide; oral
6.9
52.4
136
208
L04AA01
ATC
[U] ciclosporin; systemic
9.5
52.2
110
121
L04AC16
ATC
guselkumab; systemic
+∞
51.2
49
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
3.2
48.7
277
935
D05AX05
ATC
tazarotene; topical
125.2
45.9
49
*
M07.0
ICD-10 Finland
Distal interphalangeal psoriatic arthropathy
456.6
45.4
45
*
D02AX
ATC
Other emollients and protectives
5.7
45.3
136
252
WXQ12
NOMESCO Finland
Psoralen - Ultraviolet A therapy with local sensitivisation
47.4
42.1
51
11
D05AC01
ATC
dithranol; topical
146.0
40.9
43
*
A46
ICD-10 Finland
Erysipelas
2.4
38.4
371
1715
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.0
37.9
239
860
D07CC01
ATC
betamethasone and antibiotics; topical
2.4
36.5
346
1582
M25.5
ICD-10 Finland
Pain in joint
1.9
36.4
642
3844
L40.1
ICD-10 Finland
Generalized pustular psoriasis
+∞
33.4
32
*
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.3
33.3
331
1544
J01FF01
ATC
clindamycin; systemic
1.9
33.0
632
3871
M13.9
ICD-10 Finland
Arthritis, unspecified
2.9
32.7
208
753
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
5.9
32.5
93
163
N02AX02
ATC
tramadol; systemic, rectal
1.7
31.8
952
6722
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
31.5
711
4592
J01DB01
ATC
cefalexin; oral
1.8
30.9
1796
15364
E000004
ATC
NA
6.2
30.7
84
139
L88
ICPC
Rheumatoid/seropositive arthritis
3.8
30.0
133
367
H02AB07
ATC
prednisone; oral
2.2
29.9
349
1749
L04AA11
ATC
[U] etanercept; parenteral
21.9
29.6
43
20
L43.8
ICD-10 Finland
Other lichen planus
37.6
29.3
37
10
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
29.2
227
927
M07.2*L40.5
ICD-10 Finland
Psoriatic spondylitis
+∞
28.2
27
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
5.1
28.1
91
185
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
27.6
651
4225
D05AX
ATC
Other antipsoriatics for topical use
274.2
26.8
27
*
D09AB01
ATC
zinc bandage without supplements; topical
6.0
26.5
74
126
C03CA01
ATC
furosemide; systemic
1.8
26.2
607
3907
NH3EA
NOMESCO Finland
Feet X-ray examination with load
5.3
25.7
80
156
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.3
24.9
237
1075
J01DA01
ATC
[U] cefalexin; systemic
1.6
24.7
1340
10810
L30.3
ICD-10 Finland
Infective dermatitis
3.7
24.3
109
304
A02BC02
ATC
pantoprazole; systemic
1.6
23.9
1390
11362
N05BB01
ATC
hydroxyzine; systemic
2.7
23.6
164
626
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
23.6
1213
9603
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
23.2
515
3250
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
22.4
509
3233
R06AE07
ATC
cetirizine; oral
1.6
21.2
870
6460
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
21.1
842
6207
D07AC14
ATC
methylprednisolone aceponate; topical
3.0
21.1
128
449
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
21.0
586
3938
L28
ICPC
Limited function/disability (L)
1.9
20.2
329
1863
UJF32
NOMESCO Finland
Coloscopy
1.7
20.2
556
3717
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
20.1
300
1647
SPAT1263
SPAT
Sampling
1.5
20.1
868
6504
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
20.0
219
1056
XQ848
NOMESCO Finland
Dermatological photography
4.0
20.0
82
213
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.3
19.7
102
320
WQ031
NOMESCO Finland
NA
201.7
19.6
20
*
D07AB01
ATC
clobetasone; topical
3.6
19.4
89
254
S97
ICPC
Chronic ulcer skin
2.7
19.4
134
508
XQ802
NOMESCO Finland
Epicutan test
3.2
19.4
105
341
S29
ICPC
Skin symptom/complaint other
1.8
19.1
356
2113
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
6.3
18.8
50
81
299
Kela drug reimbursment
NA
+∞
18.8
18
*
L26
ICD-10 Finland
Exfoliative dermatitis
18.9
18.6
28
15
L04AX01
ATC
azathioprine; systemic
2.9
18.5
117
422
N02BE01
ATC
paracetamol; systemic, rectal
1.6
18.3
1830
16402
M04AA01
ATC
allopurinol; systemic
1.9
18.3
289
1617
TNG10
NOMESCO Finland
Puncture of knee
5.8
18.1
51
89
WX110
NOMESCO Finland
Local anesthesy
1.5
18.1
1406
11871
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
18.0
566
3898
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.0
17.8
231
1198
M07.1*L40.5
ICD-10 Finland
Arthritis mutilans
+∞
17.7
17
*
WQ021
NOMESCO Finland
NA
37.0
17.6
22
6
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.3
17.6
161
715
UJF30
NOMESCO Finland
Ileoscopy through colon
2.1
17.5
215
1091
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.1
17.4
205
1020
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
17.4
278
1560
SPAT1262
SPAT
Handing over of treatment supplies
1.7
17.3
396
2496
S02CA02
ATC
flumetasone and antiinfectives; otic
2.5
17.2
139
578
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.6
16.9
125
496
E66.8
ICD-10 Finland
Other obesity
2.6
16.8
124
492
L40.2
ICD-10 Finland
Acrodermatitis continua
+∞
16.7
16
*
E66.00
ICD-10 Finland
Metabolic syndrome
2.5
16.6
132
546
R60.0
ICD-10 Finland
Localized oedema
2.0
16.5
230
1226
S18
ICPC
Laceration/cut
1.5
16.4
845
6494
WZA10
NOMESCO Finland
Long statement of health and health related matters
5.2
16.4
50
97
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.8
16.4
287
1661
A10BA02
ATC
metformin; oral
1.6
16.3
570
4017
S76
ICPC
Skin infection other
2.6
16.3
124
500
K50.1
ICD-10 Finland
Crohn disease of large intestine
5.6
16.2
47
86
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.6
16.0
122
492
RJ411
NOMESCO Finland
NA
9.0
15.9
33
37
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
15.7
339
2096
R03AC02
ATC
salbutamol; inhalant
1.4
15.3
1039
8408
J02AC01
ATC
fluconazole; systemic
1.5
15.3
755
5731
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.9
15.3
239
1331
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
15.2
502
3478
TPH04
NOMESCO Finland
Cathetrisation of vein
1.6
15.2
433
2891
L04AB06
ATC
golimumab; parenteral
7.4
15.0
35
48
M45
ICD-10 Finland
Ankylosing spondylitis
3.7
14.9
64
175
R06.0
ICD-10 Finland
Dyspnoea
1.6
14.8
493
3426
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.2
14.7
152
715
L43.9
ICD-10 Finland
Lichen planus, unspecified
9.8
14.7
29
30
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.9
14.7
234
1310
D07AC03
ATC
desoximetasone; topical
4.2
14.7
55
133
H02AB04
ATC
methylprednisolone; systemic
1.7
14.6
305
1864
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.0
14.5
202
1077
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
14.5
286
1720
L04AB05
ATC
certolizumab pegol; parenteral
17.1
14.3
22
13
D01AC02
ATC
miconazole; topical
2.0
14.2
184
955
G47.3
ICD-10 Finland
Sleep apnoea
1.6
14.2
448
3069
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
14.0
303
1875
E66.01
ICD-10 Finland
Obesity due to excess calories
2.1
14.0
163
810
L17
ICPC
Foot/toe symptom/complaint
1.5
13.9
489
3431
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.5
13.9
108
441
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.2
13.8
141
661
N05CF01
ATC
zopiclone; oral
1.5
13.8
640
4774
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
3.0
13.6
79
272
L04AC18
ATC
risankizumab; parenteral
+∞
13.6
13
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
2.5
13.5
109
454
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
3.6
13.4
60
170
M54.5
ICD-10 Finland
Low back pain
1.5
13.4
632
4722
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
13.4
322
2049
J01MA02
ATC
ciprofloxacin; systemic
1.4
13.3
779
6076
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
13.3
221
1258
A06AD11
ATC
lactulose; oral
1.7
13.2
275
1680
A10BJ02
ATC
liraglutide; parenteral
3.4
13.2
64
194
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
13.1
567
4161
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.4
13.0
800
6291
XQ800
NOMESCO Finland
Prick test
2.1
12.9
144
699
D07XB02
ATC
triamcinolone, combinations; topical
4.3
12.9
47
111
R4180
NOMESCO Finland
Podiatric therapy
5.3
12.8
38
72
SPAT1254
SPAT
Administration of medicine
1.7
12.8
281
1742
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.2
12.8
137
657
A02BC01
ATC
omeprazole; systemic
1.5
12.8
541
3947
160
Kela drug reimbursment
exenatide
3.6
12.7
57
162
TQW99
NOMESCO Finland
Other minor procedure on skin
2.4
12.7
108
464
R03BB04
ATC
tiotropium bromide; inhalant
1.8
12.7
212
1205
J45.9
ICD-10 Finland
Asthma, unspecified
1.6
12.6
334
2180
K50.8
ICD-10 Finland
Other Crohn disease
4.2
12.6
47
114
L43.0
ICD-10 Finland
Hypertrophic lichen planus
70.3
12.6
14
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
12.6
227
1322
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.6
12.6
56
159
RJ421
NOMESCO Finland
NA
8.3
12.5
27
33
A10AE04
ATC
insulin glargine; parenteral
1.9
12.5
196
1089
WQ032
NOMESCO Finland
NA
+∞
12.5
12
*
L04AA21
ATC
efalizumab; parenteral
+∞
12.5
12
*
A10BH01
ATC
sitagliptin; oral
1.9
12.5
196
1092
N05CD07
ATC
temazepam; oral
1.7
12.4
256
1557
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.2
12.3
123
572
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
12.2
528
3866
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
12.1
677
5215
M01AH01
ATC
celecoxib; oral (coxibs)
1.6
11.9
358
2412
N06AB04
ATC
citalopram; systemic
1.5
11.8
422
2958
L04AA17
ATC
[U] adalimumab; parenteral
11.8
11.8
21
18
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
3.5
11.8
54
157
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
11.8
538
3981
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.8
11.7
199
1138
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.0
11.6
160
848
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
11.6
545
4052
D11AH04
ATC
alitretinoin; oral
65.3
11.6
13
*
J01MA12
ATC
levofloxacin; systemic
1.6
11.6
372
2545
J01CE02
ATC
phenoxymethylpenicillin; oral
1.4
11.5
1372
11995
N05BA04
ATC
oxazepam; oral
1.5
11.5
474
3428
RJ420
NOMESCO Finland
NA
10.1
11.5
22
22
M09.0*L40.5
ICD-10 Finland
Juvenile arthritis in psoriasis
+∞
11.5
11
*
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
11.4
1017
8471
EBA00
NOMESCO Finland
Extraction of tooth
1.4
11.4
622
4757
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
11.3
1065
8949
J01CE08
ATC
benzathine benzylpenicillin; parenteral
5.1
11.2
34
67
NG1DA
NOMESCO Finland
X-ray of knees
3.3
11.1
55
170
D07AC09
ATC
budesonide; topical
12.8
11.1
19
15
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
1.8
11.1
186
1058
B01AB05
ATC
enoxaparin; parenteral
1.4
11.1
584
4432
T82
ICPC
Obesity
2.6
11.0
79
311
A07EC02
ATC
mesalazine; oral, rectal
2.1
11.0
119
572
Z71.8
ICD-10 Finland
Other specified counselling
1.5
11.0
429
3065
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
4.2
11.0
41
100
M10.9
ICD-10 Finland
Gout, unspecified
2.0
11.0
141
729
N03AX16
ATC
pregabalin; oral
1.5
11.0
452
3267
K02.1
ICD-10 Finland
Caries of dentine
1.4
10.9
1082
9146
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.1
10.9
125
619
SPAT1211
SPAT
Application of soft bandage
1.8
10.8
178
1007
M79.6
ICD-10 Finland
Pain in limb
1.4
10.8
670
5239
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
10.7
145
764
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
10.7
224
1368
M01CB01
ATC
sodium aurothiomalate; parenteral
3.8
10.7
44
118
E66.9
ICD-10 Finland
Obesity, unspecified
2.6
10.6
76
299
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.7
10.6
210
1260
T90
ICPC
Diabetes non-insulin dependent
1.5
10.6
452
3287
J01CF05
ATC
flucloxacillin; systemic
2.5
10.6
82
337
N06AX11
ATC
mirtazapine; oral
1.4
10.5
604
4654
A10BB12
ATC
glimepiride; oral
2.0
10.5
143
756
WQ054
NOMESCO Finland
NA
110.5
10.4
11
*
M073, L409
ICD-10 Finland
NA
+∞
10.4
10
*
WX290
NOMESCO Finland
Other blockade of nerve
1.4
10.4
815
6618
A03
ICPC
Fever
1.6
10.3
278
1816
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
10.3
334
2285
D01AE15
ATC
terbinafine; topical
1.9
10.3
148
801
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.4
10.3
492
3658
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
5.5
10.3
29
53
D07CB01
ATC
triamcinolone and antibiotics; topical
3.3
10.2
50
154
N05BA01
ATC
diazepam; systemic, rectal
1.6
10.2
258
1660
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
10.2
307
2067
C07AB07
ATC
bisoprolol; oral
1.3
10.1
922
7657
R50.9
ICD-10 Finland
Fever, unspecified
1.6
10.1
264
1714
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
10.1
622
4849
WZA90
NOMESCO Finland
Other doctors statement
1.5
10.0
426
3091
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
10.0
233
1466
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.2
10.0
97
445
SPAT1229
SPAT
Assessment of need for aid
1.9
10.0
153
847
WQ066
NOMESCO Finland
NA
40.2
10.0
12
*
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
2.9
10.0
59
208
SPAT1255
SPAT
Intravenous administration of medicine
2.0
9.9
131
688
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
4.1
9.8
37
92
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.5
9.8
76
313
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
9.7
904
7518
D07XB05
ATC
dexamethasone, combinations; topical
2.7
9.7
65
244
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.9
9.7
147
810
K50.9
ICD-10 Finland
Crohn disease, unspecified
3.8
9.7
40
108
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
9.7
183
1085
J01FA06
ATC
roxithromycin; oral
1.3
9.6
774
6295
C09AA02
ATC
enalapril; systemic
1.5
9.6
373
2658
S21
ICPC
Skin texture symptom/complaint
1.6
9.6
232
1476
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
9.5
745
6026
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
9.5
760
6171
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
9.4
215
1343
R4110
NOMESCO Finland
Physiotherapy
1.4
9.4
513
3905
WQ053
NOMESCO Finland
NA
+∞
9.4
9
*
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
9.4
1367
12127
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.3
9.4
46
143
D11
ICPC
Diarrhoea
1.7
9.4
188
1132
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
9.3
572
4440
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
9.3
162
934
N02AA05
ATC
oxycodone; systemic
1.6
9.3
263
1743
M01AE02
ATC
naproxen; oral, rectal
1.3
9.3
1091
9375
M05BA04
ATC
alendronic acid; oral
1.9
9.2
143
794
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.3
9.2
84
374
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
9.2
313
2167
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
9.2
188
1142
L60.9
ICD-10 Finland
Nail disorder, unspecified
4.5
9.1
31
70
N07BB01
ATC
disulfiram; oral
2.2
9.1
94
445
A41.9
ICD-10 Finland
Sepsis, unspecified
2.4
9.1
75
318
L60.0
ICD-10 Finland
Ingrowing nail
2.2
9.1
89
412
TPH07
NOMESCO Finland
Cathetrisation of artery
1.7
9.1
204
1272
SPAT1301
SPAT
No procedures
1.4
9.1
595
4669
B35.6
ICD-10 Finland
Tinea inguinalis [Tinea cruris]
3.4
9.1
42
125
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.9
9.1
132
718
A28
ICPC
Limited function/disability NOS
1.6
9.1
260
1727
SPAT1312
SPAT
General health counselling
1.4
9.0
580
4533
QXA70
NOMESCO Finland
Guidance related to rash and skin care
36.8
9.0
11
*
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
3.7
9.0
38
105
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.5
8.9
374
2702
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
3.8
8.9
36
96
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
8.9
300
2069
J01AA02
ATC
doxycycline; systemic
1.3
8.8
1588
14455
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.1
8.8
96
465
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.2
8.8
89
419
C08CA01
ATC
amlodipine; oral
1.3
8.7
669
5381
AA1AD
NOMESCO Finland
CT of head and brain
1.4
8.7
442
3315
D05AD01
ATC
trioxysalen; topical
50.2
8.7
10
*
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.8
8.6
147
841
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
8.6
341
2431
B01AB10
ATC
tinzaparin; parenteral
1.9
8.6
132
729
J01DA06
ATC
[U] cefuroxime; systemic
1.5
8.6
271
1844
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.2
8.6
81
371
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
8.6
692
5607
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.5
8.6
296
2051
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.7
8.6
58
221
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
8.6
360
2602
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.6
8.5
226
1472
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
8.4
899
7577
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
8.4
957
8139
162
Kela drug reimbursment
liraglutide
4.0
8.4
32
81
M01AH02
ATC
rofecoxib; oral
1.6
8.4
252
1691
J01FA10
ATC
azithromycin; systemic
1.3
8.4
1092
9460
N03AX12
ATC
gabapentin; oral
1.5
8.4
284
1962
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
4.5
8.4
28
63
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.7
8.3
53
196
4AA12
NOMESCO Finland
NA
9.5
8.3
16
17
C03DA01
ATC
spironolactone; oral
1.6
8.2
200
1273
Z01.8
ICD-10 Finland
Other specified special examinations
1.4
8.2
395
2926
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
8.2
696
5677
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
2.6
8.1
56
217
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
2.4
8.1
66
280
SPAT1153
SPAT
Removal of sutures
1.3
8.1
610
4881
F10.09
ICD-10 Finland
Alcohol intoxication UNS
2.9
8.0
47
166
D06BB04
ATC
podophyllotoxin; topical
2.1
8.0
86
416
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.8
8.0
143
835
L30.4
ICD-10 Finland
Erythema intertrigo
3.6
7.9
34
96
M01AC06
ATC
meloxicam; systemic, rectal
1.3
7.9
698
5712
D01AC03
ATC
econazole; topical
1.8
7.9
132
753
N05AH04
ATC
quetiapine; oral
1.5
7.9
283
1978
R5140
NOMESCO Finland
Monitoring the use of the aid
1.6
7.9
201
1296
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
2.6
7.9
55
216
ZX120
NOMESCO Finland
Intravenous
1.6
7.9
179
1122
F10.20
ICD-10 Finland
Alcohol dependence currently independent
2.8
7.8
47
169
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
2.3
7.8
67
293
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
7.8
298
2108
H60.8
ICD-10 Finland
Other otitis externa
2.6
7.8
52
200
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
7.8
786
6558
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.1
7.8
84
406
ZX112
NOMESCO Finland
Subcutaneous
2.8
7.7
49
180
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.2
7.7
75
349
A10BJ06
ATC
semaglutide; parenteral
2.3
7.7
67
296
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.6
7.7
205
1336
L84
ICD-10 Finland
Corns and callosities
2.3
7.6
69
310
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.4
7.6
462
3563
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
7.6
469
3630
A10AE05
ATC
insulin detemir; parenteral
1.9
7.6
112
612
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
3.3
7.6
36
111
L08.0
ICD-10 Finland
Pyoderma
4.5
7.6
25
56
R51.80
ICD-10 Finland
Headache
1.5
7.5
243
1657
N06AX16
ATC
venlafaxine; oral
1.5
7.5
240
1635
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.4
7.5
345
2534
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.6
7.5
52
203
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
2.4
7.5
60
255
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
7.5
501
3932
RS221
NOMESCO Finland
NA
3.2
7.4
37
118
L03.0
ICD-10 Finland
Cellulitis of finger and toe
1.8
7.4
122
694
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
7.4
166
1035
I50.9
ICD-10 Finland
Heart failure, unspecified
1.5
7.4
227
1536
WX320
NOMESCO Finland
Spinalanesthesy
1.4
7.4
406
3083
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
1.9
7.4
101
541
M01AH05
ATC
etoricoxib; oral
1.3
7.4
1136
9997
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
3.8
7.3
29
77
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.2
7.3
74
348
R02
ICPC
Shortness of breath/dyspnoea
1.6
7.3
212
1411
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.5
7.3
238
1627
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.7
7.3
144
865
-1
NOMESCO Finland
NA
1.3
7.3
577
4635
WQ022
NOMESCO Finland
NA
+∞
7.3
7
*
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
4.9
7.3
22
45
K50.0
ICD-10 Finland
Crohn disease of small intestine
3.2
7.2
36
115
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.4
7.2
388
2931
L30.0
ICD-10 Finland
Nummular dermatitis
2.2
7.2
66
299
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
3.1
7.2
37
121
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
7.2
738
6154
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.2
7.2
71
333
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
1.9
7.2
99
529
S81.9
ICD-10 Finland
Open wound of lower leg, part unspecified
4.4
7.1
24
55
P01AB01
ATC
metronidazole; oral, rectal
1.3
7.1
724
6029
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
7.1
179
1153
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.6
7.1
188
1224
WX002
NOMESCO Finland
Sedation and analgesia
1.4
7.1
360
2692
K07
ICPC
Swollen ankles/oedema
2.1
7.0
75
364
L85.9
ICD-10 Finland
Epidermal thickening, unspecified
8.8
7.0
14
16
J01FA01
ATC
erythromycin; systemic
1.5
7.0
239
1652
WX110
SPAT
NA
2.0
7.0
86
442
N06AX21
ATC
duloxetine; oral
1.6
7.0
192
1262
P01BA02
ATC
hydroxychloroquine; oral
1.7
7.0
146
891
M01AX01
ATC
nabumetone; oral
2.0
7.0
85
433
WX780
NOMESCO Finland
Remote monitoring CPAP
2.1
7.0
76
370
N03AG01
ATC
valproic acid; systemic, rectal
1.8
7.0
107
595
L20.0
ICD-10 Finland
Besnier prurigo
1.9
7.0
103
564
N06AB10
ATC
escitalopram; oral
1.4
6.9
335
2483
L03
ICPC
Low back symptom/complaint
1.4
6.9
417
3208
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
6.9
1063
9321
A10BX07
ATC
[U] liraglutide; parenteral
3.4
6.9
31
92
A02BC03
ATC
lansoprazole; oral
1.3
6.9
535
4284
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
2.1
6.9
74
362
R56.8
ICD-10 Finland
Other and unspecified convulsions
1.9
6.9
95
511
WZC30
NOMESCO Finland
Teaching
1.5
6.8
246
1719
RS340
NOMESCO Finland
NA
8.3
6.8
14
17
K08.3
ICD-10 Finland
Retained dental root
1.7
6.8
131
784
L02
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle
2.2
6.8
66
308
205
Kela drug reimbursment
Chronic hypertension
1.3
6.8
518
4134
J45.1
ICD-10 Finland
Nonallergic asthma
1.7
6.8
122
714
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.2
6.8
65
299
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
9.3
6.8
13
14
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
2.4
6.8
55
236
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.3
6.8
478
3771
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.2
6.7
63
289
A02BC05
ATC
esomeprazole; systemic
1.3
6.7
751
6319
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
6.7
423
3279
R4120
NOMESCO Finland
Occupational therapy
1.8
6.7
116
669
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.6
6.7
150
935
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
2.6
6.7
47
185
WQ020
NOMESCO Finland
NA
22.6
6.7
9
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.2
6.6
62
287
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
1.9
6.5
84
439
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.3
6.5
808
6884
R53
ICD-10 Finland
Malaise and fatigue
1.4
6.5
343
2581
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
2.0
6.5
73
363
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
1.8
6.5
101
565
M01AB01
ATC
indometacin; systemic, rectal
1.6
6.5
149
938
J31.0
ICD-10 Finland
Chronic rhinitis
1.7
6.5
131
796
M07
ICD-10 Finland
Psoriatic and enteropathic arthropathies
70.0
6.4
7
*
M40.5
ICD-10 Finland
Lordosis, unspecified
70.0
6.4
7
*
EBA30
NOMESCO Finland
Excision of root of tooth
1.8
6.4
101
569
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
6.4
1186
10595
52100
ICD-8 Finland
Disease of hard tissues of teeth, Dental caries
14.3
6.4
10
7
R05
ICPC
Cough
1.4
6.4
378
2900
F10.25
ICD-10 Finland
Alcohol dependence continuous use
2.6
6.4
42
161
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
6.4
231
1617
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
6.4
420
3279
E0001A1
ATC
NA
2.9
6.4
37
131
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
3.3
6.3
29
88
M54
ICD-10 Finland
Dorsalgia
1.5
6.3
186
1244
J01AA07
ATC
tetracycline; systemic
1.4
6.3
258
1851
2780A
ICD-9 Finland
Obesity and other hyperalimentation, Obesity
5.2
6.3
18
35
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
1.9
6.3
84
444
L30.8
ICD-10 Finland
Other specified dermatitis
2.6
6.3
42
163
K50
ICD-10 Finland
Crohn disease [regional enteritis]
9.3
6.3
12
13
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
1.5
6.3
220
1531
N06AB03
ATC
fluoxetine; oral
1.5
6.3
220
1532
L04AC
ATC
Interleukin inhibitors
+∞
6.3
6
*
M07.2
ICD-10 Finland
Psoriatic spondylitis
+∞
6.3
6
*
L405, L400
ICD-10 Finland
NA
+∞
6.3
6
*
N07.3
ICD-10 Finland
Hereditary nephropathy, not elsewhere classified, diffuse mesangial proliferative glomerulonephritis
+∞
6.3
6
*
M09.0
ICD-10 Finland
Juvenile arthritis in psoriasis
+∞
6.3
6
*
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.6
6.3
161
1044
N06AA09
ATC
amitriptyline; systemic
1.5
6.2
176
1168
S22.3
ICD-10 Finland
Fracture of rib
1.7
6.2
117
697
69282
ICD-8 Finland
Other eczema and dermatitis, E microbis
7.0
6.2
14
20
SGA01
NOMESCO Finland
Tooth opening as first aid
1.4
6.2
271
1970
F10.24
ICD-10 Finland
Alcohol depence active use
3.0
6.2
33
112
Z72.1
ICD-10 Finland
Alcohol use
3.3
6.2
29
90
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.1
6.2
62
296
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.9
6.2
87
471
L21.0
ICD-10 Finland
Seborrhoea capitis
3.3
6.1
28
85
M47.9
ICD-10 Finland
Spondylosis, unspecified
2.1
6.1
61
288
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.0
6.1
73
373
291
Kela drug reimbursment
Tofacitinib
7.7
6.1
13
17
K59.1
ICD-10 Finland
Functional diarrhoea
1.8
6.1
96
538
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
2.8
6.1
36
130
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
1.8
6.1
94
525
B07.9
ICD-10 Finland
Verruca simplex
2.2
6.1
58
269
H70
ICPC
Otitis externa
2.6
6.1
40
154
RJ412
NOMESCO Finland
NA
8.6
6.1
12
14
N07BA03
ATC
varenicline; oral
1.9
6.0
88
482
N05CF02
ATC
zolpidem; oral
1.4
6.0
303
2259
SPAT1281
SPAT
Other administrative function
1.6
6.0
140
885
N05AA02
ATC
levomepromazine; systemic
1.9
6.0
78
411
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
3.4
6.0
26
76

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1723
10120
3.20
162.50
11.4
5.6
0.6
0.6
e9/l
6.77
1566
8750
1725
10163
3.19
161.30
11.5
5.6
0.0
0.0
e9/l
5.85
1570
8788
1742
10415
3.15
156.77
11.4
5.7
1.9
1.9
e9/l
0.40
1598
9186
1333
6888
2.97
156.75
10.4
5.7
—
—
—
0
0
1744
10518
3.11
152.82
11.8
5.8
0.2
0.2
e9/l
1.69
1599
9241
1583
9214
2.91
145.00
11.8
5.9
0.7
0.7
%
3.62
1540
8596
1602
9493
2.87
139.82
11.9
5.8
2.9
2.8
%
0.10
1559
8844
1607
9539
2.87
139.77
12.2
6.1
8.8
8.7
%
1.41
1566
8924
1623
9799
2.83
134.52
12.0
5.9
27.4
27.8
%
0.96
1578
9133
1835
11844
2.99
133.26
14.2
8.9
4.2
4.1
e9/l
1.28
1674
10352
1603
9656
2.80
132.75
11.6
5.7
58.1
57.3
%
2.50
1561
9037
629
2676
2.80
98.49
1.4
1.3
375.0
501.4
titre
1.26
123
558
290
812
3.90
90.38
1.3
1.2
—
—
—
0
0
1392
9067
2.19
79.48
15.1
9.3
0.0
0.0
e9/l
0.44
1202
7412
2063
15960
2.58
75.59
11.6
7.5
80.6
78.3
u/l
1.44
1986
15065
392
1507
2.89
72.48
5.4
4.1
0.0
0.3
%
0.77
108
391
497
2166
2.61
71.96
1.5
1.6
—
—
—
0
0
408
1609
2.83
71.90
5.3
4.1
0.1
0.1
%
2.27
116
465
421
1699
2.77
70.95
5.2
4.0
0.5
0.9
%
2.62
123
506
1980
15217
2.38
70.47
6.8
3.9
15.0
12.0
mm/h
13.67
1872
14102
394
1541
2.84
70.44
4.9
3.8
0.3
0.6
%
2.36
100
367
362
1395
2.86
66.32
1.3
1.4
—
—
—
0
0
549
2616
2.40
65.02
1.5
1.6
—
—
—
0
0
112
187
6.22
64.48
1.4
1.5
57.3
28.5
iu/ml
—
6
11
515
2418
2.42
62.84
1.6
1.4
—
—
—
0
0
61
49
12.73
62.48
1.9
2.1
8.0
8.6
mg/l
0.28
49
41
791
4457
2.13
61.91
7.9
4.4
—
—
—
0
0
494
2374
2.34
56.64
2.1
1.7
—
—
—
0
0
152
387
4.11
53.52
3.8
3.5
4.0
4.2
e9/l
0.77
152
387
153
404
3.97
51.23
3.9
3.8
55.4
58.3
%
2.21
153
404
1379
9872
1.87
50.83
6.4
4.7
0.0
0.0
estimate
0.50
332
1848
1081
7184
1.88
50.24
4.8
3.6
82.8
105.6
e6/l
0.55
781
5123
1372
9842
1.86
49.87
4.8
3.5
0.0
0.0
estimate
0.00
319
1810
1790
13981
1.96
49.87
5.8
4.1
—
—
—
0
0
1385
9978
1.86
49.52
4.9
3.5
0.0
0.0
estimate
1.08
317
1771
876
5468
1.92
49.14
3.0
2.7
2142.1
4910.2
umol/l
1.99
768
4763
591
3281
2.05
46.09
1.3
1.2
15.4
12.4
u/ml
0.36
213
1290
876
5596
1.86
44.85
5.4
4.4
—
—
—
0
0
1246
8868
1.80
44.60
5.9
5.0
34.6
35.5
g/l
7.36
1159
8276
574
3192
2.03
44.35
1.7
1.7
—
—
—
0
0
603
3424
2.00
43.87
1.3
1.3
31.0
35.8
iu/ml
0.36
167
1091
669
3978
1.93
42.32
3.3
2.7
547.0
555.3
mosm/kgh2o
0.44
594
3394
936
6190
1.81
42.24
4.0
3.2
48.6
87.9
e6/l
1.68
746
4777
135
379
3.71
41.36
1.6
1.5
—
—
—
0
0
824
5281
1.83
40.96
9.7
6.5
—
—
—
0
0
200
723
2.92
40.57
1.2
1.2
0.3
1.1
u/ml
—
7
63
840
5491
1.79
38.64
3.7
3.0
—
—
—
0
0
1418
10795
1.71
37.36
7.3
6.4
11.7
11.6
umol/l
0.06
1344
10252
1148
8255
1.71
37.34
2.6
2.2
75.7
77.1
nmol/l
0.84
1048
7427
851
5630
1.77
37.29
3.8
3.1
0.3
0.4
e6/l
1.80
663
4256
98
241
4.19
36.09
1.6
1.5
54.9
60.5
%
0.62
60
159
47
59
8.10
35.01
2.6
3.6
7.7
8.4
mg/l
0.22
27
52
377
1961
2.08
34.17
2.7
2.2
0.2
0.2
g/l
1.03
352
1831
676
4272
1.79
34.08
3.1
2.6
5.3
5.4
e6/l
0.12
609
3743
156
544
2.99
33.68
1.4
1.3
—
—
—
0
0
503
2923
1.90
33.10
2.8
2.5
2.3
2.3
g/l
0.14
467
2719
1332
10181
1.65
32.74
8.2
7.0
1.2
1.2
mmol/l
1.74
1120
8606
422
2335
1.97
32.06
3.1
2.3
150.7
134.6
ug/g
0.54
348
1862
873
6016
1.69
31.90
4.4
4.1
7.4
7.4
ph
0.49
182
1159
476
2747
1.90
31.88
2.9
2.6
21.2
23.3
%
2.50
417
2356
41
51
8.16
30.76
2.4
3.2
131.2
64.7
au/ml
—
8
12
526
3174
1.83
30.46
2.8
2.5
12.1
13.3
umol/l
3.02
489
2945
76
181
4.30
29.21
1.6
1.4
36.5
30.3
%
0.60
42
116
494
2966
1.83
28.92
2.5
2.1
—
—
—
0
0
1219
9301
1.60
28.73
7.5
6.2
1.2
1.2
mmol/l
0.90
1139
8428
1120
8381
1.60
28.61
10.8
9.5
1.2
1.3
inr
0.87
352
2389
297
1548
2.04
26.42
2.4
2.8
11.1
10.5
g/l
1.56
271
1419
1500
12148
1.58
26.40
6.0
5.0
6.8
6.7
mmol/l
0.75
1436
11398
108
355
3.13
25.82
1.1
1.2
—
—
—
0
0
737
5110
1.62
25.01
2.5
2.2
3.2
3.0
mg/l
1.36
645
4344
132
495
2.76
24.92
1.8
1.6
10983.1
15244.3
e6/l
0.53
96
358
533
3423
1.71
24.25
3.8
3.5
0.8
0.8
mmol/l
4.41
508
3219
137
537
2.64
23.72
1.2
1.2
93.3
93.9
titre
—
9
44
158
665
2.47
23.60
1.1
1.1
—
—
—
0
0
677
4660
1.62
23.40
4.7
3.5
—
—
—
0
0
444
2741
1.75
23.18
6.6
6.1
1.0
1.0
mmol/l
0.10
423
2547
37
58
6.46
22.65
1.9
1.5
—
—
—
0
0
506
3270
1.68
22.28
3.4
2.9
2.9
2.2
e6/l
0.95
263
1793
2263
20632
1.91
22.21
23.9
14.1
21.9
24.3
mg/l
3.47
1998
16293
387
2325
1.78
22.12
2.9
2.7
1.8
1.8
%
0.31
351
2068
237
1217
2.05
21.84
1.6
1.8
1.3
1.4
g/l
0.86
223
1118
743
5321
1.56
21.34
5.6
3.9
0.0
0.0
estimate
1.08
314
1768
568
3824
1.63
21.18
1.5
1.5
3.1
2.5
g/l
6.96
355
2367
1581
13273
1.51
21.15
5.6
4.3
241.3
1650.5
e6/l
2.03
24
200
739
5303
1.56
20.97
5.6
3.9
86.7
89.8
%
2.81
721
5169
526
3484
1.64
20.91
3.2
2.7
1.0
1.1
e6/l
0.22
286
2005
44
89
5.01
20.66
1.5
1.3
6.9
4.3
%
0.38
12
20
192
938
2.13
20.17
1.8
1.9
1.8
1.6
g/l
1.66
156
813
878
6604
1.50
19.76
3.6
3.2
7.4
7.7
mmol/l
1.46
752
5578
856
6427
1.50
19.34
2.9
2.6
56.3
57.5
u/l
0.20
778
5944
731
5316
1.53
19.20
4.5
3.2
—
—
—
0
0
871
6589
1.49
18.85
4.4
4.0
12.4
9.1
mg/mmol
1.07
576
4213
295
1727
1.80
18.22
5.2
3.8
—
—
—
0
0
782
5834
1.49
17.93
3.7
3.0
—
—
—
0
0
372
2337
1.69
17.90
3.5
2.8
9.7
8.4
umol/l
0.32
318
2057
1082
8605
1.45
17.82
3.4
2.8
151.8
133.3
ug/l
1.31
998
7944
1918
17110
1.50
16.37
29.4
17.1
14.0
13.7
%
16.67
1898
16725
1042
8325
1.43
16.27
2.3
2.0
92.8
94.7
pmol/l
0.70
617
4395
818
6258
1.45
16.13
3.4
3.3
323.8
316.6
mg/l
0.02
550
4023
306
1883
1.71
15.80
4.4
3.9
2.0
2.0
mmol/l
0.05
258
1505
595
4297
1.50
15.63
1.4
1.2
2.6
1.6
u/ml
0.74
155
1150
129
597
2.22
15.53
2.8
3.4
—
—
—
0
0
285
1741
1.72
15.09
10.9
9.1
—
—
—
0
0
85
332
2.61
14.89
1.6
1.4
—
—
—
0
0
303
1892
1.68
14.78
4.5
3.9
5.8
5.9
kpa
0.26
295
1833
282
1737
1.70
14.46
2.4
2.7
69.4
70.3
e9/l
0.13
206
1327
297
1871
1.67
13.98
2.4
2.2
334.9
370.6
nmol/l
2.43
271
1725
215
1238
1.81
13.95
9.0
8.1
25.1
24.9
mmol/l
0.26
215
1230
516
3705
1.49
13.73
1.8
1.7
1124.8
1179.1
nmol/l
0.68
387
2820
80
320
2.55
13.38
1.1
1.1
—
—
—
0
0
964
7794
1.38
13.23
4.1
3.6
34.9
50.0
ng/l
1.01
700
5363
749
5810
1.41
13.12
3.1
3.1
1571.8
1370.4
ng/l
0.39
646
4967
287
1821
1.65
13.11
9.4
7.7
1.3
1.4
mmol/l
1.06
273
1752
176
973
1.87
13.02
4.4
4.1
24.2
24.1
mmol/l
0.08
159
875
348
2321
1.58
12.95
1.5
1.3
—
—
—
0
0
299
1923
1.63
12.94
3.1
2.4
33.8
64.1
u/l
0.66
260
1661
18
8
22.65
12.89
2.4
3.3
2.4
4.3
mg/l
—
18
8
234
1415
1.72
12.81
1.8
2.5
—
—
—
0
0
623
4697
1.43
12.74
1.9
1.5
20.6
20.4
nmol/l
0.11
550
4019
249
1538
1.69
12.60
3.6
3.2
4.8
4.6
kpa
0.91
241
1486
446
3181
1.49
12.12
2.2
2.2
30.5
29.9
s
1.47
441
3090
1563
13762
1.35
11.88
4.2
3.1
66.9
49.7
u/l
6.15
1459
12833
137
721
1.95
11.77
2.2
2.3
369.7
521.2
ug/l
0.58
127
676
67
266
2.56
11.43
4.2
2.4
—
—
—
0
0
77
328
2.39
11.31
1.1
1.0
—
—
—
0
0
780
6217
1.37
11.26
2.2
2.2
236.2
238.8
u/l
0.02
737
5850
97
458
2.16
11.19
3.8
2.8
35.6
36.6
umol/l
0.13
81
390
381
2674
1.50
11.15
9.3
7.3
104.2
104.3
mmol/l
0.22
372
2609
1730
15551
1.35
11.00
4.2
3.9
14.8
14.8
pmol/l
0.03
1568
14143
264
1713
1.60
10.98
1.9
2.8
66.7
66.6
g/l
0.11
245
1565
593
4547
1.40
10.76
1.9
1.8
1.5
1.2
mg/l
1.25
455
3487
807
6525
1.35
10.45
3.0
2.5
—
—
—
0
0
152
861
1.81
10.43
2.0
2.0
2.2
1.8
ug/l
0.25
133
766
236
1524
1.60
10.00
4.6
4.0
94.6
91.2
ng/l
0.18
202
1341
345
2428
1.49
9.90
10.1
8.2
5.4
5.1
kpa
3.78
325
2318
345
2429
1.49
9.88
10.1
8.2
11.8
12.3
kpa
0.93
325
2318
345
2430
1.49
9.86
10.1
8.2
1.2
1.1
mmol/l
0.14
294
1899
2022
18762
1.39
9.58
5.2
4.6
1.9
2.1
mu/l
1.05
1855
17164
250
1660
1.56
9.40
3.7
3.9
1.2
1.2
mmol/l
0.39
231
1446
98
499
2.00
9.31
1.3
1.2
11.8
2.5
u/ml
—
10
46
73
334
2.22
9.16
2.8
3.7
1.2
1.3
%
0.14
68
266
54
216
2.53
9.14
1.1
1.2
—
—
—
0
0
280
1924
1.51
9.00
8.8
7.8
11.3
9.8
mmol/l
2.57
272
1836
98
507
1.97
8.91
1.3
1.2
13.5
10.0
u/ml
0.12
16
83
201
1290
1.61
8.74
4.2
3.7
7.4
7.4
ph
0.26
34
157
177
1102
1.65
8.70
13.0
10.6
24.5
24.3
mmol/l
0.33
158
1043
38
131
2.93
8.55
1.1
1.1
—
—
—
0
0
202
1307
1.59
8.50
4.2
3.7
5.3
5.1
kpa
1.45
189
1214
550
4335
1.34
8.12
1.8
1.7
35920598.3
33821925.4
pmol/l
0.02
451
3619
101
547
1.88
8.05
1.3
1.2
110.9
37.9
u/ml
—
5
28
306
2188
1.45
8.05
10.6
8.7
95.1
95.7
%
0.92
298
2104
389
2912
1.40
7.92
1.3
1.2
—
—
—
0
0
87
451
1.96
7.90
3.8
3.7
—
—
—
0
0
174
1107
1.61
7.86
1.3
1.2
—
—
—
0
0
46
185
2.51
7.75
1.0
1.2
—
—
—
0
0
2307
22096
1.49
7.58
19.8
10.2
28.4
26.9
u/l
4.06
2270
21356
71
348
2.07
7.54
1.5
1.3
60.8
61.1
mmol/l
0.02
46
285
47
194
2.45
7.50
1.5
1.3
92714.9
111292.7
e6/l
0.08
34
134
110
628
1.79
7.43
2.0
3.7
1.3
2.5
ratio
—
6
55
85
447
1.93
7.43
1.3
1.7
—
—
—
0
0
32
109
2.96
7.39
2.1
1.5
—
—
—
0
0
112
1869
0.58
7.37
1.4
1.4
—
—
—
0
0
35
126
2.80
7.33
1.1
1.0
—
—
—
0
0
82
429
1.94
7.28
2.7
2.4
16.2
16.2
%
0.04
49
218
821
6921
1.28
7.24
3.7
3.4
2.3
2.4
mmol/l
0.31
727
6087
111
646
1.75
7.04
2.0
3.7
56.4
67.3
mg/l
0.38
80
525
685
5662
1.29
7.03
1.9
1.7
1.5
1.4
mmol/l
3.43
583
4764
90
492
1.86
7.01
1.5
3.9
—
—
—
0
0
125
754
1.69
6.97
2.0
2.5
11.4
10.4
g/l
1.43
108
645
538
4311
1.31
6.97
5.6
3.9
1.0
1.0
kg/l
0.11
84
620
111
648
1.75
6.97
2.0
3.7
42.7
80.9
mg/l
0.98
82
527
25
76
3.31
6.96
1.1
1.1
1434.5
1706.5
miu/ml
0.56
25
76
1109
9727
1.25
6.88
4.5
4.1
—
—
—
0
0
69
350
2.00
6.72
1.5
1.4
—
—
—
0
0
168
1102
1.56
6.70
3.9
2.8
0.3
0.3
e6/l
0.48
162
1076
76
401
1.92
6.61
4.3
2.6
—
—
—
0
0
199
1361
1.50
6.56
13.0
10.0
93.8
93.9
%
0.15
199
1355
354
2690
1.37
6.53
22.8
24.9
1.2
1.4
inr
1.94
50
381
67
341
1.99
6.47
1.3
1.3
—
—
—
0
0
44
190
2.34
6.41
1.2
1.5
7.8
7.0
g/l
0.57
22
133
2297
22084
1.43
6.34
27.5
16.4
78.7
78.4
umol/l
0.14
2297
22075
502
4038
1.30
6.26
4.3
3.7
339.1
701.5
ng/l
0.80
392
3164
84
469
1.82
6.16
4.3
4.4
8.7
8.6
kpa
0.26
84
461
84
470
1.81
6.12
4.3
4.4
5.1
5.0
kpa
0.30
84
463
184
1259
1.50
6.06
1.4
1.3
392.0
209.0
u/ml
1.08
173
1162
276
2038
1.40
6.06
11.4
9.0
121.2
122.1
g/l
0.29
269
1962
43
190
2.28
5.97
1.2
1.5
3.0
2.9
g/l
0.06
20
133
43
190
2.28
5.97
1.2
1.5
—
—
—
0
0
43
190
2.28
5.97
1.2
1.5
0.5
0.4
g/l
0.68
22
133
93
542
1.74
5.92
1.3
1.3
240.7
210.0
miu/ml
0.24
31
249
2244
21528
1.37
5.91
20.3
13.3
—
—
—
0
0
71
381
1.89
5.91
2.7
2.8
—
—
—
0
0
197
1374
1.47
5.91
12.7
9.7
1.4
1.4
%
0.06
197
1362
952
8309
1.23
5.90
2.2
2.1
—
—
—
0
0
106
642
1.68
5.88
2.2
2.4
37.5
37.8
g/l
0.23
92
560
83
470
1.79
5.83
4.3
4.4
2.6
2.5
mmol/l
0.10
54
326
196
1371
1.47
5.80
13.1
9.9
0.6
0.7
%
1.88
196
1358
34
139
2.47
5.62
1.5
1.5
—
—
—
0
0
118
744
1.61
5.61
1.7
1.7
—
—
—
0
0
83
476
1.77
5.60
3.7
1.9
—
—
—
0
0
60
310
1.96
5.60
1.4
1.7
0.8
0.8
g/l
0.00
37
234
71
1237
0.56
5.52
1.5
1.4
—
—
—
0
0
70
384
1.85
5.47
1.6
1.3
—
—
—
0
0
2224
21360
1.34
5.36
24.2
16.4
139.3
139.7
mmol/l
8.34
2181
20839
2022
19181
1.27
5.36
6.9
5.7
41.2
39.9
mmol/mol
4.37
1888
17797
89
528
1.71
5.35
3.3
3.1
26.1
24.8
mmol/l
1.53
83
458
2230
21433
1.34
5.29
24.3
16.5
4.0
4.0
mmol/l
0.60
2186
20877
47
228
2.08
5.23
3.4
4.3
—
—
—
0
0
92
557
1.68
5.15
4.1
4.1
7.4
7.4
ph
0.28
83
463
96
592
1.65
5.02
1.4
1.4
274.8
287.3
ug/g
0.26
62
346
1586
14707
1.21
4.99
4.0
3.8
—
—
—
0
0
76
441
1.75
4.97
2.5
2.2
128.7
129.7
g/l
0.14
57
321
207
1508
1.41
4.94
1.2
1.2
—
—
—
0
0
165
1159
1.45
4.81
11.9
11.6
—
—
—
0
0
92
568
1.64
4.80
3.9
3.5
1.7
1.5
mg/l
0.60
87
522
596
5040
1.24
4.79
2.8
2.4
—
—
—
0
0
138
941
1.49
4.68
4.7
3.8
—
—
—
0
0
36
165
2.20
4.65
2.0
2.1
40.2
45.4
%
—
5
25
193
1409
1.40
4.56
4.1
3.1
4.2
4.1
e9/l
0.27
153
1115
97
616
1.60
4.54
1.2
1.2
—
—
—
0
0
36
168
2.16
4.47
3.0
1.4
1.8
1.3
promille
1.01
27
133
12
30
4.01
4.43
1.8
1.5
—
—
—
0
0
696
6026
1.21
4.41
4.2
3.8
—
—
—
0
0
93
594
1.59
4.27
1.2
1.2
—
—
—
0
0
53
290
1.85
4.25
3.1
2.6
—
—
—
0
0
18
62
2.92
4.17
2.6
2.2
—
—
—
0
0
175
1279
1.40
4.13
1.2
1.3
75.6
54.7
au/ml
—
6
62
29
128
2.28
4.13
1.2
1.1
27.3
33.9
mmol/l
0.85
23
119
89
569
1.58
4.08
3.5
2.0
—
—
—
0
0
33
157
2.12
3.94
1.2
1.4
1.9
2.0
mmol/l
0.65
26
147
83
527
1.59
3.93
2.5
2.3
139.7
112.3
ug/min
0.20
49
324
235
1816
1.32
3.90
1.4
1.4
—
—
—
0
0
59
344
1.73
3.87
3.0
3.3
—
—
—
0
0
31
145
2.15
3.86
2.1
1.4
1407.0
1838.1
ml
—
6
28
83
530
1.59
3.85
1.2
1.1
—
—
—
0
0
189
1420
1.36
3.79
2.3
2.4
30.8
22.3
au/ml
—
7
74
56
324
1.74
3.78
5.4
5.6
357.0
363.7
umol/l
0.13
49
288
37
188
1.98
3.73
2.3
2.2
1.1
1.1
e9/l
0.02
21
105
71
440
1.63
3.73
3.0
3.1
—
—
—
0
0
40
210
1.92
3.68
3.2
3.4
—
—
—
0
0
116
806
1.46
3.65
4.9
4.0
24.9
24.8
mmol/l
0.04
104
754
145
1051
1.40
3.63
2.7
2.3
—
—
—
0
0
16
56
2.87
3.62
1.1
1.2
—
—
—
0
0
76
486
1.58
3.53
2.4
2.2
1816.1
3249.2
u/l
0.53
21
198
106
730
1.47
3.50
3.2
3.2
0.3
0.3
g/l
0.07
51
301
6
6
10.02
3.49
1.0
1.0
—
—
—
0
0
22
93
2.38
3.48
3.2
2.8
—
—
—
0
0
77
499
1.56
3.39
5.2
4.3
—
—
—
0
0
29
140
2.08
3.37
1.7
2.1
14.4
13.3
%
—
10
63
91
615
1.50
3.32
3.5
1.9
—
—
—
0
0
216
1690
1.30
3.31
4.6
3.3
—
—
—
0
0
26
123
2.13
3.20
3.5
3.6
—
—
—
0
0
91
621
1.48
3.18
3.5
1.9
—
—
—
0
0
61
381
1.62
3.15
2.9
3.0
0.9
0.8
nmol/l
0.78
44
288
83
557
1.51
3.14
1.9
2.0
10.6
11.5
mg/l
0.36
78
512
19
79
2.42
3.13
1.7
3.0
279.2
138.9
umol/l
—
9
45
61
382
1.61
3.12
1.5
1.5
105.9
121.7
u/ml
0.47
18
63
216
1704
1.29
3.12
3.1
2.9
269.8
193.9
ng/l
1.04
189
1547
158
1193
1.35
3.12
2.7
3.5
4.4
4.5
pmol/l
0.38
140
1058
184
1421
1.32
3.11
6.4
5.5
—
—
—
0
0
44
253
1.75
3.09
1.2
1.3
—
—
—
0
0
66
423
1.58
3.08
1.5
1.5
—
—
—
0
0
90
618
1.47
3.06
3.5
1.9
—
—
—
0
0
6
8
7.51
3.05
1.0
1.0
—
—
—
0
0
43
247
1.75
3.04
1.2
1.2
—
—
—
0
0
62
393
1.59
3.03
1.3
1.2
241.0
259.9
u/ml
0.25
46
246
18
75
2.41
2.97
1.6
2.0
—
—
—
0
0
88
606
1.47
2.96
3.3
1.8
—
—
—
0
0
47
280
1.69
2.93
2.7
2.7
—
—
—
0
0
24
472
0.50
2.93
1.5
1.7
—
—
—
0
0
6
9
6.68
2.87
1.2
1.0
—
—
—
0
0
52
322
1.63
2.82
1.2
1.3
—
—
—
0
0
116
852
1.38
2.76
6.2
4.7
—
—
—
0
0
187
1475
1.29
2.74
1.6
1.4
—
—
—
0
0
172
1342
1.30
2.73
9.5
7.8
25.3
24.5
mmol/l
2.07
162
1249
17
72
2.37
2.72
1.8
1.3
—
—
—
0
0
108
789
1.39
2.66
2.5
2.2
22.5
21.5
s
0.51
95
693
13
49
2.66
2.62
1.3
1.1
—
—
—
0
0
15
61
2.47
2.62
1.9
2.4
—
—
—
0
0
435
3776
1.18
2.58
3.3
3.0
2.5
2.4
mmol/l
3.22
388
3341
260
2152
1.23
2.54
4.4
4.2
4.7
24.5
ug/l
3.13
219
1752
7
16
4.38
2.47
2.4
1.1
—
—
—
0
0
114
852
1.35
2.46
5.7
6.3
1.7
1.7
%
0.01
106
793
15
63
2.39
2.46
3.1
1.5
12.6
13.3
g/l
—
10
48
5
8
6.26
2.37
1.6
2.3
11.6
22.6
mmol/l
—
5
8
12
46
2.62
2.36
1.2
1.2
—
—
—
0
0
2078
20173
1.17
2.35
5.1
4.5
6.2
6.0
mmol/l
6.21
1891
18420
121
922
1.33
2.32
1.7
1.8
—
—
—
0
0
15
65
2.32
2.31
1.3
1.6
—
—
—
0
0
76
537
1.43
2.30
1.3
1.3
502.1
523.0
mg/l
0.21
68
502
27
148
1.83
2.28
1.3
1.1
—
—
—
0
0
12
47
2.56
2.27
1.2
1.0
—
—
—
0
0
12
47
2.56
2.27
1.2
1.0
—
—
—
0
0
12
47
2.56
2.27
1.2
1.0
—
—
—
0
0
218
1795
1.23
2.26
2.3
2.4
5.8
7.6
ug/l
1.50
191
1616
177
1427
1.26
2.22
1.6
1.6
—
—
—
0
0
316
2708
1.19
2.18
1.4
1.3
—
—
—
0
0
65
452
1.45
2.16
2.7
3.5
189.0
916.2
u/ml
0.69
59
419
6
14
4.29
2.15
2.7
1.1
0.5
0.5
%
—
6
8
7
19
3.69
2.15
1.0
1.0
—
—
—
0
0
7
19
3.69
2.15
1.0
1.0
—
—
—
0
0
63
437
1.45
2.13
1.2
1.5
—
—
—
0
0
17
81
2.11
2.12
3.6
2.7
410.0
785.3
e6/l
0.91
12
66
15
68
2.21
2.11
1.1
1.3
—
—
—
0
0
38
236
1.62
2.11
3.0
2.8
—
—
—
0
0
25
138
1.82
2.09
2.8
2.1
—
—
—
0
0
13
56
2.33
2.04
1.2
1.1
188.1
276.1
pmol/l
—
8
41
110
846
1.31
2.01
5.8
6.4
0.8
0.9
%
1.47
103
790
20
104
1.93
2.00
2.4
2.3
943.9
1120.9
u/ml
0.21
20
104
398
4503
0.86
2.00
2.9
3.0
0.7
0.8
ug/l
1.51
269
2983
33
201
1.65
1.98
2.9
3.8
59.2
56.2
%
0.32
27
135
89
665
1.35
1.98
6.4
7.6
1.3
1.3
mmol/l
0.03
78
576
2039
19838
1.14
1.93
4.8
4.0
1.4
1.3
mmol/l
11.06
1889
18196
25
142
1.77
1.93
2.1
2.0
7.1
6.9
mmol/l
0.13
18
91
15
71
2.12
1.92
3.7
2.4
1201.7
25518.9
e6/l
—
7
45
10
39
2.57
1.92
1.1
1.0
—
—
—
0
0
109
844
1.30
1.91
2.7
2.6
—
—
—
0
0
36
228
1.59
1.87
1.3
2.2
—
—
—
0
0
16
79
2.03
1.85
2.9
2.6
26.8
30.1
umol/l
—
9
55
111
868
1.29
1.83
1.0
1.1
—
—
—
0
0
39
254
1.54
1.81
1.4
1.6
—
—
—
0
0
32
201
1.60
1.74
2.4
3.0
25.4
29.4
mg/l
0.12
22
152
5
13
3.85
1.71
1.0
1.1
—
—
—
0
0
53
374
1.43
1.69
1.6
1.6
—
—
—
0
0
31
195
1.60
1.68
1.2
1.2
—
—
—
0
0
18
97
1.86
1.66
1.3
1.2
—
—
—
0
0
18
97
1.86
1.66
1.2
1.1
—
14.6
u/ml
—
0
9
7
25
2.80
1.65
1.0
1.0
—
—
—
0
0
8
32
2.50
1.59
2.0
1.7
123.2
131.1
ng/l
—
8
32
7
26
2.70
1.58
1.1
1.7
63.1
47.5
umol/l
—
7
26
2110
20642
1.13
1.57
5.4
4.4
4.5
4.7
mmol/l
6.62
1974
19166
22
129
1.71
1.56
2.0
2.1
495.6
490.6
min
0.06
15
93
68
509
1.35
1.56
1.5
1.3
13.0
9.9
u/l
0.77
53
406
27
168
1.61
1.55
2.1
2.3
850.3
624.4
ml
0.84
16
113
235
2030
1.17
1.53
1.4
1.5
—
—
—
0
0
48
340
1.42
1.53
1.3
1.1
6.3
113.6
iu/ml
2.05
12
72
33
217
1.53
1.51
1.6
1.3
270.6
280.5
mosm/kgh2o
0.75
22
170
24
146
1.65
1.50
1.2
1.2
—
—
—
0
0
96
767
1.26
1.39
3.9
3.5
91.9
5309.4
u/ml
0.83
87
657
22
134
1.65
1.39
2.5
2.3
0.2
0.2
e9/l
0.12
17
120
63
476
1.33
1.39
1.3
1.3
3.9
3.8
mmol/l
0.11
56
444
123
1013
1.23
1.37
4.8
3.3
—
—
—
0
0
5
17
2.94
1.36
1.2
1.3
136.4
145.5
mmol/l
—
5
12
10
47
2.13
1.33
1.8
2.0
—
—
—
0
0
36
249
1.45
1.33
1.7
1.5
—
—
—
0
0
36
249
1.45
1.33
1.7
1.5
—
—
—
0
0
36
249
1.45
1.33
1.7
1.5
—
—
—
0
0
36
249
1.45
1.33
1.7
1.5
—
—
—
0
0
1932
18860
1.10
1.32
26.1
15.1
39.3
40.0
%
2.28
1311
13581
24
152
1.58
1.31
1.1
1.2
46.0
43.0
mg/l
0.06
16
124
19
113
1.69
1.31
1.0
1.0
—
—
—
0
0
2331
23008
1.16
1.30
35.6
20.7
255.0
249.3
e9/l
3.74
2297
22436
250
2211
1.15
1.23
1.7
1.6
—
—
—
0
0
22
139
1.59
1.23
2.7
2.3
268.1
548.1
e6/l
2.82
17
121
2331
23021
1.16
1.22
35.5
20.6
91.9
91.0
fl
15.74
2309
22696
8
37
2.17
1.21
1.3
1.1
—
—
—
0
0
8
37
2.17
1.21
1.4
1.4
—
—
—
0
0
14
78
1.80
1.21
6.1
2.9
—
—
—
0
0
2331
23023
1.16
1.20
35.4
20.6
30.5
30.3
pg
3.70
2308
22695
23
148
1.56
1.20
1.0
1.1
313.8
293.2
mg/l
0.08
16
125
2331
23025
1.16
1.19
35.6
20.6
4.4
4.5
e12/l
9.65
2293
22388
8
38
2.11
1.18
1.3
1.6
—
—
—
0
0
6
127
0.47
1.16
6.8
6.7
—
—
—
0
0
159
1366
1.17
1.16
1.2
1.3
—
—
—
0
0
46
611
0.75
1.16
1.1
1.1
—
—
—
0
0
2331
23031
1.15
1.16
35.7
20.7
7.1
6.7
e9/l
12.41
2294
22393
2331
23032
1.15
1.15
35.8
20.8
134.2
136.1
g/l
7.27
2311
22707
60
465
1.30
1.15
1.3
1.5
9.8
28.8
e6/l
0.76
39
355
60
465
1.30
1.15
1.3
1.5
172.8
861.6
e6/l
1.32
42
372
15
87
1.73
1.15
5.9
2.8
—
—
—
0
0
151
1296
1.18
1.12
1.1
1.2
51.2
148.6
iu/ml
7.72
56
480
32
225
1.43
1.12
1.2
1.5
—
—
—
0
0
5
21
2.38
1.09
1.2
1.1
127.2
230.7
ug/l
—
5
10
82
666
1.24
1.09
6.4
4.2
3.9
3.9
mmol/l
0.07
76
618
8
41
1.95
1.08
1.3
1.9
—
—
—
0
0
8
41
1.95
1.08
1.3
1.3
—
—
—
0
0
94
777
1.22
1.06
1.5
1.4
28.5
30.5
iu/l
0.26
76
660
10
52
1.93
1.06
2.4
1.6
—
—
—
0
0
14
82
1.71
1.05
1.3
8.8
78.5
76.5
mg/l
—
6
64
23
154
1.50
1.03
2.9
2.2
568.7
683.4
e6/l
0.35
11
69
5
22
2.28
1.03
1.2
1.5
31.8
21.1
%
—
5
14
5
22
2.28
1.03
1.0
1.1
—
—
—
0
0
83
1004
0.82
1.00
1.6
1.7
—
—
—
0
0
14
84
1.67
0.97
3.3
2.6
—
—
—
0
0
23
157
1.47
0.96
1.3
1.3
0.8
0.8
u/ml
—
7
78
6
27
2.23
0.93
1.2
1.1
—
—
—
0
0
18
118
1.53
0.90
1.4
1.2
—
—
—
0
0
32
236
1.36
0.89
1.5
1.3
—
—
nmol/l
—
0
0
34
254
1.34
0.88
1.6
1.5
0.2
0.3
nmol/l
1.15
22
191
24
169
1.42
0.87
1.2
1.2
304.8
383.8
nmol/l
1.33
17
150
61
495
1.24
0.86
1.5
2.0
2.4
5.1
iu/l
3.85
13
173
13
80
1.63
0.84
1.4
1.7
—
—
—
0
0
28
205
1.37
0.83
1.2
1.2
—
—
—
0
0
2081
20506
1.08
0.83
5.0
4.4
1.4
1.4
mmol/l
12.93
1922
18927
36
275
1.31
0.82
1.5
1.3
0.6
0.6
nmol/l
0.03
36
262
33
249
1.33
0.82
1.5
1.4
215.8
297.2
pmol/l
1.36
26
196
2130
21014
1.09
0.81
5.6
4.9
2.7
2.8
mmol/l
4.68
1973
19403
10
58
1.73
0.79
1.5
1.8
—
—
—
0
0
11
66
1.67
0.78
2.1
1.9
0.4
1.3
ug/l
2.06
11
59
5
100
0.50
0.77
1.0
1.1
—
—
—
0
0
11
67
1.64
0.75
1.2
1.1
—
—
—
0
0
9
54
1.67
0.74
1.1
1.4
-1.0
0.8
mmol/l
—
9
48
5
25
2.00
0.72
1.0
1.2
—
—
—
0
0
10
60
1.67
0.72
1.4
1.5
—
—
—
0
0
54
446
1.22
0.68
1.3
2.0
0.9
0.8
nmol/l
0.48
45
368
12
77
1.56
0.68
1.7
1.8
16.6
19.2
ug/l
0.16
12
68
5
27
1.85
0.68
1.2
1.3
—
—
—
0
0
11
69
1.60
0.68
4.1
5.1
—
—
—
0
0
55
458
1.21
0.65
1.8
1.9
193.0
209.5
pmol/l
0.56
50
434
12
78
1.54
0.65
1.6
1.5
1.7
2.0
umol/l
0.48
12
71
10
62
1.62
0.65
1.3
1.1
—
—
—
0
0
16
112
1.43
0.63
2.1
3.1
7.4
7.4
ph
—
6
35
8
49
1.63
0.62
4.1
1.7
—
—
—
0
0
29
226
1.29
0.61
1.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
17
122
1.40
0.60
1.1
1.2
142.7
139.1
nmol/l
0.15
17
122
15
105
1.43
0.60
1.4
1.6
9.6
8.6
ug/l
0.16
15
91
8
53
1.51
0.58
1.1
1.0
—
—
—
0
0
17
123
1.38
0.57
1.3
1.2
1.0
1.1
ratio
—
10
48
15
106
1.42
0.57
1.9
1.6
—
—
—
0
0
223
2065
1.09
0.57
4.3
4.3
—
—
—
0
0
19
141
1.35
0.56
1.1
1.4
11.5
12.3
mmol/l
—
8
40
719
7454
0.95
0.55
3.3
2.8
—
—
—
0
0
71
617
1.16
0.54
1.7
1.6
279.5
312.9
mu/l
0.36
64
563
9
60
1.50
0.54
1.2
1.8
—
—
—
0
0
26
204
1.28
0.54
1.3
1.2
—
—
—
0
0
6
41
1.46
0.50
2.2
2.2
14.5
19.4
umol/l
—
6
41
12
84
1.43
0.49
10.1
12.9
—
—
—
0
0
15
110
1.37
0.48
1.3
1.7
—
—
—
0
0
1729
17533
0.96
0.48
31.8
18.1
331.4
332.6
g/l
5.85
1720
17412
14
102
1.37
0.47
1.9
2.5
—
—
—
0
0
21
165
1.28
0.45
1.9
1.5
1.0
1.0
g/l
0.04
21
165
31
256
1.21
0.44
1.5
1.3
—
—
—
0
0
22
175
1.26
0.43
2.9
2.1
5.7
1.8
u/field
—
7
78
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.6
1.2
—
—
—
0
0
27
223
1.21
0.39
2.5
2.4
—
—
—
0
0
26
214
1.22
0.39
1.3
1.2
—
—
—
0
0
25
205
1.22
0.39
2.1
1.9
—
—
—
0
0
10
71
1.41
0.39
1.0
1.1
—
—
—
0
0
20
248
0.80
0.39
1.5
1.4
—
—
—
0
0
20
247
0.81
0.38
1.5
1.4
—
—
—
0
0
21
257
0.82
0.37
1.6
1.4
—
—
—
0
0
15
116
1.29
0.37
2.0
2.3
—
—
—
0
0
19
152
1.25
0.37
1.1
1.2
—
—
—
0
0
20
162
1.24
0.35
1.2
1.1
—
—
—
0
0
13
167
0.78
0.34
1.1
1.1
—
—
—
0
0
36
311
1.16
0.34
1.3
1.2
—
—
—
0
0
32
274
1.17
0.34
1.1
1.0
1.2
2.2
u/ml
1.94
12
123
54
482
1.12
0.33
8.8
8.9
11.2
11.3
mmol/l
0.06
48
427
54
483
1.12
0.32
8.8
8.9
104.0
105.5
mmol/l
2.16
48
428
27
229
1.18
0.32
1.3
1.2
—
—
—
0
0
26
220
1.18
0.31
1.3
1.5
17664.3
75327.6
e6/l
1.13
16
133
29
248
1.17
0.31
1.3
1.3
—
—
—
0
0
39
342
1.14
0.31
1.3
1.1
4.8
2.0
u/ml
0.28
16
145
177
1676
1.06
0.30
2.1
2.2
11.3
13.0
nmol/l
2.04
152
1473
10
75
1.33
0.30
2.8
2.2
—
—
—
0
0
17
207
0.82
0.30
1.3
1.0
0.1
0.4
u/ml
—
6
54
8
64
1.25
0.27
1.3
1.2
—
—
—
0
0
25
215
1.16
0.26
1.2
1.1
0.7
3.8
u/ml
—
10
81
16
132
1.21
0.25
9.8
13.9
1115.8
837.3
nmol/l
1.82
16
127
9
73
1.23
0.25
1.0
1.0
—
—
—
0
0
39
435
0.89
0.25
1.3
1.3
—
—
—
0
0
43
476
0.90
0.24
1.8
2.0
—
—
—
0
0
15
124
1.21
0.24
1.1
1.0
—
—
—
0
0
33
294
1.12
0.23
1.2
1.2
—
—
—
0
0
16
134
1.20
0.23
1.8
2.1
2.7
2.1
ug/l
0.41
11
115
25
219
1.14
0.22
1.3
1.7
—
—
—
0
0
13
107
1.22
0.21
1.3
1.8
—
10.4
—
0
7
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
5
42
1.19
0.21
1.6
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
13.1
—
0
12
8
104
0.77
0.21
1.1
1.2
—
—
—
0
0
49
450
1.09
0.21
4.3
3.7
28.4
26.9
mg/l
0.10
29
282
0
14
0.00
0.20
0.0
1.4
—
357.8
—
0
14
25
221
1.13
0.20
2.7
2.3
—
—
—
0
0
28
250
1.12
0.19
1.5
1.5
2599.9
1764.8
e6/l
0.21
22
181
23
203
1.13
0.19
1.3
1.6
—
—
—
0
0
15
175
0.86
0.18
1.1
1.4
72.4
222.7
pmol/l
—
8
59
35
318
1.10
0.18
1.5
1.2
8.8
5.2
u/ml
0.41
16
142
180
1737
1.04
0.18
1.4
1.4
—
—
—
0
0
125
1303
0.96
0.17
4.4
2.8
—
—
—
0
0
9
78
1.15
0.15
1.2
1.1
—
—
—
0
0
26
237
1.10
0.14
1.2
1.1
2.1
2.9
u/ml
—
9
86
22
199
1.11
0.13
1.7
2.0
—
—
—
0
0
15
132
1.14
0.13
1.1
1.6
—
—
—
0
0
14
159
0.88
0.13
1.4
1.5
—
73.3
—
0
16
33
307
1.08
0.12
1.2
1.1
3.1
6.1
u/ml
0.59
16
154
65
680
0.95
0.11
15.5
9.6
—
—
—
0
0
33
308
1.07
0.11
1.1
1.1
—
—
—
0
0
12
107
1.12
0.08
1.2
1.3
—
—
—
0
0
561
5662
0.99
0.08
1.5
1.4
—
—
—
0
0
7
66
1.06
0.08
1.9
1.9
—
—
—
0
0
7
67
1.04
0.08
3.7
2.5
—
—
—
0
0
6
72
0.83
0.07
1.2
1.3
—
—
—
0
0
8
93
0.86
0.06
1.9
1.4
24.5
28.3
umol/l
—
8
88
8
95
0.84
0.06
1.4
1.5
—
—
—
0
0
20
189
1.06
0.04
1.7
1.5
—
—
—
0
0
46
474
0.97
0.04
1.1
1.2
—
—
—
0
0
22
209
1.05
0.04
1.2
1.5
—
—
—
0
0
32
308
1.04
0.04
1.1
1.1
—
—
—
0
0
31
299
1.04
0.03
1.2
1.1
0.6
1.9
u/ml
0.95
15
128
11
117
0.94
0.01
1.4
1.4
—
—
—
0
0
769
7677
1.00
0.01
4.4
4.9
2.4
2.8
ug/l
0.40
675
6890
10
101
0.99
0.00
1.0
1.2
—
—
—
0
0
28
285
0.98
0.00
1.2
1.1
0.3
2.2
u/ml
—
7
67
20
201
0.99
0.00
1.4
1.5
—
—
—
0
0
16
158
1.01
0.00
1.3
1.6
2.0
4.8
ug/l
0.92
11
134
21
208
1.01
0.00
1.6
1.6
—
—
—
0
0
22
222
0.99
0.00
3.2
2.8
—
—
—
0
0
7
72
0.97
0.00
1.0
1.0
—
—
—
0
0
7
71
0.99
0.00
1.6
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
42.9
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
1140.2
—
0
6
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
0.00
3.2
2.6
—
—
—
0
0
7
74
0.95
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
259.0
—
0
5
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
2.2
—
0
9
0
9
0.00
0.00
0.0
1.9
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_PSORI_NAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_PSORI_NAS 1.614 [1.41, 1.85] < 0.001
Birth year 0.995 [0.99, 1.0] 0.201

During the follow-up period (1.1.1998 — 31.12.2019), 797 out of 4508 females with L12_PSORI_NAS died.

Males

Parameter HR [95% CI] p-value
L12_PSORI_NAS 2.294 [2.01, 2.61] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1294 out of 5256 males with L12_PSORI_NAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_NAS.

N-year risk Females Males
1 0.15% 0.417%
5 0.863% 2.543%
10 2.182% 6.287%
15 4.563% 11.503%
20 8.04% 18.71%

Relationships between endpoints

Index endpoint: L12_PSORI_NAS – Other and unspecified psoriasis

GWS hits: 9

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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