preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
9313 |
4. Check minimum number of eventsNone |
9313 |
5. Include endpointsNone |
9313 |
6. Filter based on genotype QC (FinnGen only) |
9313 |
Control definitions (FinnGen only)
- Control exclude
- O15_OEDEM_PROTUR_HYPERT
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF5
- Parent code in ICD-10
- O10-O16
- Name in latin
- Hypertensio gestationalis cum proteinuria significanti
Similar endpoints
↥List of similar endpoints to
Pre-eclampsia
based on the number of shared cases.
Similar with more cases:
- Pregnancy hypertension
- Oedema, proteinuria and hypertensive disorders in pregnancy, childbirth and the puerperium
- Delivery, wide proxy
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 64134 | 64134 | - |
| Only index persons | 62521 | 62521 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.84 | 1.84 | - |
| Only index persons | 2.30 | 2.30 | - |
| Median age at first event (years) | |||
| Whole population | - | 28.58 | - |
| Only index persons | - | 28.55 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9313 | 9313 | - |
| Unadjusted period prevalence (%) | 3.17 | 3.17 | - |
| Median age at first event (years) | 28.74 | 28.74 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 8471
- Matched controls
- 84709
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
2901.9
323.0
564
*
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
4140.9
323.0
1726
5
63703
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Prae-eclampsia levis
+∞
323.0
1975
*
C07AG01
ATC
labetalol; systemic
51.9
323.0
595
123
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
3.5
323.0
2167
7565
6424B
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, SYNNYTYKSEN AIKANA]
+∞
323.0
351
*
6425A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Severe pre-eclampsia[PRAE-ECLAMPSIA GRAVIS, ENNEN SYNNYTYSTÄ]
+∞
323.0
311
*
6424A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, ENNEN SYNNYTYSTÄ]
+∞
323.0
1258
*
O14.1
ICD-10 Finland
Severe pre-eclampsia
11342.4
323.0
1012
*
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
+∞
323.0
2468
*
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
2578.8
323.0
2104
10
63704
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Prae-eclampsia gravis
+∞
323.0
426
*
6423A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Transient hypertension of pregnancy[HYPERTENSIO GRAVIDARUM, ENNEN SYNNYTYSTÄ]
+∞
320.9
306
*
63701
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Hypertonia
+∞
317.7
303
*
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
4.0
284.4
1273
3575
205
Kela drug reimbursment
Chronic hypertension
3.1
252.7
1658
6234
I10
ICD-10 Finland
Essential (primary) hypertension
2.2
235.0
3650
21806
O12.1
ICD-10 Finland
Gestational proteinuria
468.3
230.1
229
5
6425B
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Severe pre-eclampsia[PRAE-ECLAMPSIA GRAVIS, SYNNYTYKSEN AIKANA]
+∞
226.0
216
*
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
2.8
185.8
1403
5660
8811
FHL
Cesarean section
3.2
183.6
1063
3591
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.7
182.8
1415
5792
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
2.2
174.8
2221
11746
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
3.1
174.6
1087
3858
C09AA02
ATC
enalapril; systemic
2.8
162.7
1226
4907
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.5
158.8
1428
6319
103
Kela drug reimbursment
Diabetes, insulin-treated
2.4
157.5
1646
7874
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
155.0
1620
7745
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
6.3
148.8
416
686
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.5
138.2
701
2121
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
4.1
131.2
544
1383
C08CA05
ATC
nifedipine; systemic
3.9
130.3
584
1592
A10BA02
ATC
metformin; oral
2.1
124.8
1658
8749
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.9
121.5
2142
12626
6420X
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Benign essential hypertension complicating pregnancy, childbirth and the puerperium
+∞
121.1
116
*
O60
ICD-10 Finland
Preterm labour and delivery
4.0
120.3
517
1356
Z39.2
ICD-10 Finland
Routine postpartum follow-up
2.0
119.9
1816
10090
C08CA01
ATC
amlodipine; oral
2.0
116.1
1912
10955
O16
ICD-10 Finland
Unspecified maternal hypertension
114.4
114.3
124
11
W84
ICPC
Pregnancy high risk
3.4
113.7
609
1913
E66.01
ICD-10 Finland
Obesity due to excess calories
2.5
113.1
977
4171
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
4.2
105.2
428
1066
A10AE04
ATC
insulin glargine; parenteral
3.0
102.6
659
2349
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
1.7
101.8
2940
20130
63700
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Albuminuria (proteinuria)
+∞
99.1
95
*
SPAT1262
SPAT
Handing over of treatment supplies
2.1
97.3
1209
6130
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.0
94.3
579
1998
T90
ICPC
Diabetes non-insulin dependent
2.0
92.6
1294
6877
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.7
92.5
670
2571
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
89.5
1168
6028
O12.0
ICD-10 Finland
Gestational oedema
55.9
88.3
105
19
SPAT1379
SPAT
Health check-up of pregnant person
1.9
88.3
1447
8164
O11
ICD-10 Finland
Pre-eclampsia superimposed on chronic hypertension
+∞
87.6
84
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
3.7
85.7
393
1087
C07AB02
ATC
metoprolol; systemic
2.0
83.8
1180
6269
63702
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Oedema
+∞
80.3
77
*
A10AE05
ATC
insulin detemir; parenteral
3.2
77.9
447
1469
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.8
77.5
346
934
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.1
76.4
441
1454
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
3.5
73.9
363
1061
63709
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Prae-eclampsia NUD
+∞
73.0
70
*
C07AB07
ATC
bisoprolol; oral
1.6
72.6
2622
18636
XMA22
NOMESCO Finland
General examination of pregnant woman
2.2
71.8
815
3934
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
2.8
70.9
497
1863
C09BA02
ATC
enalapril and diuretics; systemic
3.0
69.9
427
1465
C09CA01
ATC
losartan; oral
1.8
69.8
1372
8180
O30.0
ICD-10 Finland
Twin pregnancy
3.8
67.8
305
829
Z32.1
ICD-10 Finland
Pregnancy confirmed
1.8
67.6
1258
7355
A10AA01
ATC
NA
3.7
67.0
306
842
T89
ICPC
Diabetes insulin dependent
3.2
67.0
375
1210
A10AA02
ATC
NA
3.6
66.4
312
880
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.4
65.8
250
582
W78
ICPC
Pregnancy
1.7
65.5
1747
11402
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
5.4
65.5
203
380
MAC96
NOMESCO Finland
Other induction or advancement of labour
3.0
65.1
404
1399
E66.8
ICD-10 Finland
Other obesity
2.4
64.4
598
2616
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
1.9
62.4
1104
6328
MAA00
NOMESCO Finland
Amniocentesis
3.0
62.4
378
1288
O82.0
ICD-10 Finland
Delivery by elective caesarean section
2.2
61.7
648
3010
SPAT1197
SPAT
Extensive health check-up of expecting family
1.7
61.3
1557
9997
H04AA01
ATC
glucagon; nasal, parenteral
3.7
60.8
278
766
B01AB05
ATC
enoxaparin; parenteral
1.6
60.2
2106
14705
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
2.0
59.7
862
4586
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.7
59.6
1460
9267
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
3.9
58.5
250
650
O12.2
ICD-10 Finland
Gestational oedema with proteinuria
+∞
58.4
56
*
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
3.2
57.5
321
1033
C09DA01
ATC
losartan and diuretics; oral
2.2
57.4
606
2818
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.9
56.7
371
1330
O10.9
ICD-10 Finland
Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium
+∞
56.3
54
*
6462A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Unspecified renal disease in pregnancy, without mention of hypertension
+∞
56.3
54
*
C03CA01
ATC
furosemide; systemic
1.8
54.0
1131
6829
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.7
53.5
1244
7751
SPAT1263
SPAT
Sampling
1.4
53.3
3357
26477
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.9
53.2
341
1206
66180
ICD-8 Finland
Occipital presentation
3.4
53.2
270
810
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.8
52.9
961
5537
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.5
52.5
262
776
40199
ICD-8 Finland
Essential benign hypertension
8.0
50.5
117
148
C09CA06
ATC
candesartan; oral
1.6
50.4
1525
10195
WX320
NOMESCO Finland
Spinalanesthesy
1.6
50.1
1646
11233
SPAT1380
SPAT
Postpartum check-up
1.7
49.5
1121
6913
A10BK03
ATC
empagliflozin; oral
2.4
49.1
426
1798
C08CA13
ATC
lercanidipine; oral
2.0
49.0
665
3440
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.9
48.1
209
552
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
2.3
46.2
464
2105
C09AA05
ATC
ramipril; oral
1.7
45.0
1010
6202
E66.9
ICD-10 Finland
Obesity, unspecified
2.6
45.0
348
1378
SPAT1357
SPAT
Monitoring of problem during pregnancy
2.5
44.1
376
1572
O61.0
ICD-10 Finland
Failed medical induction of labour
4.1
43.8
179
448
W81
ICPC
Toxaemia of pregnancy
96.6
43.8
48
5
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
3.1
42.5
250
834
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
1.7
42.5
1086
6914
66120
ICD-8 Finland
Occipital presentation
18.0
42.2
66
37
C03AA03
ATC
hydrochlorothiazide; oral
2.1
42.1
497
2425
C02CB01
ATC
NA
40.3
41.5
52
13
C02EA02
ATC
NA
4.2
41.5
163
394
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
3.0
41.1
254
877
A10AE06
ATC
insulin degludec; parenteral
3.0
41.0
248
844
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
40.0
3160
25544
W92
ICPC
Compl labour/ delivery livebirth
2.7
39.7
284
1077
A10BH01
ATC
sitagliptin; oral
2.2
39.6
446
2132
C02AC05
ATC
moxonidine; oral
3.2
39.2
214
680
WX306
NOMESCO Finland
Lumbar epidural anesthesy
1.8
39.1
774
4564
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
1.9
39.0
597
3227
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
6.2
38.8
107
175
W85
ICPC
Gestational diabetes
2.1
38.7
470
2320
E66.00
ICD-10 Finland
Metabolic syndrome
2.3
38.6
371
1648
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.6
38.2
1093
7155
C08CA02
ATC
felodipine; oral
2.2
37.9
392
1801
J01DA01
ATC
[U] cefalexin; systemic
1.3
37.9
5090
44657
A10BJ06
ATC
semaglutide; parenteral
2.9
37.7
241
852
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
5.4
37.6
116
218
SPAT1196
SPAT
Monitoring of normal pregnancy
1.7
36.6
834
5129
C09DA06
ATC
candesartan and diuretics; oral
2.1
36.5
423
2045
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.5
35.7
172
497
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
2.7
35.7
259
990
J01DB01
ATC
cefalexin; oral
1.4
35.4
6655
61265
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.8
35.4
714
4229
H3603, E103
ICD-10 Finland
NA
4.7
34.8
121
260
C10AA01
ATC
simvastatin; oral
1.4
34.6
1718
12702
H3600, E103
ICD-10 Finland
NA
4.2
34.4
135
327
O99.80
ICD-10 Finland
The fear of childbirth
1.8
33.4
581
3280
K85
ICPC
Elevated blood pressure
1.7
33.4
769
4739
O10.1
ICD-10 Finland
Pre-existing hypertensive heart disease complicating pregnancy, childbirth and the puerperium
+∞
33.3
32
*
6480A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Diabetes mellitus
4.7
33.2
116
251
O14
ICD-10 Finland
Pre-eclampsia
328.4
32.9
33
*
A10AD01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3.9
32.6
139
364
6440B
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]
3.0
31.7
192
657
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
1.8
31.0
579
3342
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.6
30.8
852
5512
H3601, E103
ICD-10 Finland
NA
4.8
30.6
104
219
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
4.1
30.5
121
297
G47.3
ICD-10 Finland
Sleep apnoea
1.5
30.4
1148
7994
C07AG02
ATC
carvedilol; oral
2.5
30.2
246
1004
6423B
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Transient hypertension of pregnancy[HYPERTENSIO GRAVIDARUM, SYNNYTYKSEN AIKANA]
+∞
30.2
29
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
1.6
30.2
953
6370
160
Kela drug reimbursment
exenatide
3.5
30.1
147
431
K86
ICPC
Hypertension uncomplicated
1.8
29.8
525
2976
N02BE01
ATC
paracetamol; systemic, rectal
1.4
29.5
6855
63928
C10AA05
ATC
atorvastatin; oral
1.4
29.4
1622
12181
310
Kela drug reimbursment
Orlistat, sibutramine and other major and expensive medicines used to treat obesity
4.2
28.9
113
274
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
2.8
28.6
188
678
A10BB12
ATC
glimepiride; oral
2.5
28.5
228
921
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.6
28.3
908
6086
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
28.2
991
6785
SPAT1310
SPAT
Counselling related to known health issue
1.3
28.2
2284
18272
E10
ICD-10 Finland
Type 1 diabetes mellitus
3.0
28.2
169
575
Z30.2
ICD-10 Finland
Sterilization
1.5
28.1
1087
7601
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
5.1
28.0
90
179
WX307
NOMESCO Finland
Obstetric epidural analgesia
1.6
27.9
872
5807
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
2.5
27.5
216
867
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.1
27.3
331
1632
A10BK01
ATC
dapagliflozin; oral
2.4
27.2
242
1035
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
27.2
477
2699
A10BJ02
ATC
liraglutide; parenteral
3.0
27.2
163
555
A12BA01
ATC
potassium chloride; oral
3.1
26.9
155
514
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
1.5
26.8
1177
8442
SPAT1008
SPAT
Photography of fundus of the eye or interpretation of photograph
2.6
26.4
199
781
XCK10
NOMESCO Finland
Photography of fundus of eye
1.8
26.2
506
2952
6565A
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Poor foetal growth[SIKIÖN HIDASTUNUT INTRAUTERIININ KASVU,RASK AIK]
5.7
26.1
76
135
T82
ICPC
Obesity
2.0
26.0
339
1724
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.4
25.9
1174
8468
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.0
25.5
354
1841
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
2.4
25.2
221
940
SPAT1301
SPAT
No procedures
1.3
25.1
2090
16728
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
3.6
24.6
111
307
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
2.4
24.6
219
939
6563B
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Foetal distress[ASPHYXIA FOETALIS, SYNNYTYKSEN AIKANA]
2.4
24.2
216
928
6461A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Oedema or excessive weight gain in pregnancy, without mention of hypertension
+∞
24.0
23
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.9
23.7
366
1983
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
2.5
23.6
191
779
6565B
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Poor foetal growth[SIKIÖN HIDASTUNUT INTRAUTERIININ KASVU,SYNN AIK]
7.6
23.5
55
73
O21.9
ICD-10 Finland
Vomiting of pregnancy, unspecified
2.7
23.4
162
606
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
3.2
23.0
124
394
WX290
NOMESCO Finland
Other blockade of nerve
1.3
22.9
3735
32596
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
4.6
22.7
80
177
H36.00
ICD-10 Finland
Diabetic background retinopathy
3.6
22.6
103
288
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
3.7
22.5
99
269
WX892
NOMESCO Finland
Monitored bed care
1.8
22.4
367
2030
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
5.6
22.4
65
116
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
4.4
22.3
81
185
K02.1
ICD-10 Finland
Caries of dentine
1.3
21.9
4604
41303
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
21.9
2839
24047
177
Kela drug reimbursment
Insulin glargine 300 U / ml
2.8
21.6
137
486
4019X
ICD-9 Finland
Essential hypertension, Unspecified
4.6
21.5
75
164
C07FB02
ATC
metoprolol and felodipine; systemic
3.2
21.4
114
360
C10AA07
ATC
rosuvastatin; oral
1.4
21.4
1142
8477
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
21.3
2316
19158
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
4.9
21.3
70
144
C09CA03
ATC
valsartan; oral
1.8
21.0
375
2136
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
20.7
4197
37393
R51.80
ICD-10 Finland
Headache
1.4
20.5
1192
8975
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
20.5
3327
28888
C03BA11
ATC
indapamide; oral
2.8
20.5
134
485
Z39.1
ICD-10 Finland
Care and examination of lactating mother
2.1
20.3
231
1110
SPAT1153
SPAT
Removal of sutures
1.3
20.2
1910
15487
BEF00
NOMESCO Finland
Continuous subcutaneous glucose monitoring
3.8
20.2
86
228
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
20.1
655
4393
WX110
NOMESCO Finland
Local anesthesy
1.2
20.0
5511
50717
6488A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Abnormal glucose tolerance
2.4
20.0
174
738
A10BX07
ATC
[U] liraglutide; parenteral
3.6
19.9
89
246
O41.0
ICD-10 Finland
Oligohydramnios
2.2
19.9
211
986
J01CA08
ATC
pivmecillinam; oral
1.2
19.8
4055
36084
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
1.9
19.8
302
1628
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
1.8
19.6
318
1751
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
2.4
19.6
166
697
W29
ICPC
Pregnancy symptom/complaint other
1.9
19.5
276
1449
O28.8
ICD-10 Finland
Other abnormal findings on antenatal screening of mother
2.8
19.5
129
470
O02.1
ICD-10 Finland
Missed abortion
1.6
19.4
582
3827
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.5
19.3
611
4071
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
19.3
2332
19507
A08AB01
ATC
orlistat; oral
4.4
19.2
70
161
65700
ICD-8 Finland
Occipital presentation
2.9
19.2
114
390
QBJ30
NOMESCO Finland
Correction of abdominal apron
3.1
19.1
107
352
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.3
18.9
1948
15958
63799
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Toxaemia, unspecified
+∞
18.8
18
*
C09AA03
ATC
lisinopril; oral
2.2
18.7
192
884
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
18.6
1834
14933
C01DA14
ATC
isosorbide mononitrate; oral
1.8
18.4
298
1642
C07BB07
ATC
bisoprolol and thiazides; systemic
2.1
18.4
205
978
E66
ICD-10 Finland
Obesity
1.8
18.3
345
1997
O63.0
ICD-10 Finland
Prolonged first stage (of labour)
2.0
18.2
232
1172
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
18.1
2077
17234
25009
ICD-8 Finland
Diabetes mellitus, Unspecified
5.4
18.0
54
101
C07AB03
ATC
atenolol; systemic
2.0
18.0
225
1127
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
17.9
4675
42497
C09DA03
ATC
valsartan and diuretics; oral
2.1
17.9
215
1060
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
17.8
693
4829
O15.0
ICD-10 Finland
Eclampsia in pregnancy
+∞
17.7
17
*
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
17.7
1412
11153
CKC12
NOMESCO Finland
Photocoagulation of retina
1.9
17.6
242
1259
H36.01
ICD-10 Finland
Diabetic maculopathy
3.8
17.5
73
191
A10AA03
ATC
NA
3.8
17.5
73
191
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
1.3
17.4
1515
12109
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.5
17.4
535
3539
SPAT1097
SPAT
Recording of ECG
1.5
17.3
723
5114
O68.8
ICD-10 Finland
Labour and delivery complicated by other evidence of fetal stress
2.7
17.3
115
422
O46.0
ICD-10 Finland
Antepartum haemorrhage with coagulation defect
20.9
17.3
25
12
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
17.2
449
2853
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.4
17.1
801
5790
6542B
ICD-9 Finland
Abnormality of organs and soft tissues of pelvis, Previous Caesarean delivery[CICATRIX UTERI POSTOPERATIVA, SYNNYTYKSEN AIKANA]
2.7
17.0
114
420
M04AA01
ATC
allopurinol; systemic
1.8
16.7
313
1808
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.4
16.7
817
5953
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.4
16.6
973
7316
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
1.7
16.6
381
2339
MWE00
NOMESCO Finland
Reoperation for deep haemorrhage in obstetric surgery
6.9
16.6
41
60
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.1
16.2
90
295
N02AX02
ATC
tramadol; systemic, rectal
1.2
16.2
2588
22260
LGA10
NOMESCO Finland
Sterilisation by destruction or division of Fallopian tubes
2.6
16.1
116
445
J01CA04
ATC
amoxicillin; systemic
1.3
16.1
6660
63151
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.3
16.1
1857
15386
J01AA02
ATC
doxycycline; systemic
1.2
16.0
6088
57157
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.2
16.0
2906
25331
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
1.7
16.0
365
2237
162
Kela drug reimbursment
liraglutide
3.5
15.8
74
214
FM1QE
NOMESCO Finland
Extensive ultrasound of fetal heart
3.2
15.8
83
262
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.3
15.8
1038
7948
V230A
ICD-9 Finland
Supervision of high-risk pregnancy, Pregnancy with history of infertility
2.6
15.7
114
442
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
15.7
905
6790
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.4
15.4
790
5799
B01AC04
ATC
clopidogrel; oral
1.6
15.4
388
2445
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
1.6
15.3
417
2682
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
15.3
4310
39187
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.0
15.2
88
296
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.1
15.1
177
867
8221
FHL
Sterilization of the laparotomy pathway
1.8
15.1
262
1482
R80
ICD-10 Finland
Isolated proteinuria
4.4
15.0
54
124
M79.6
ICD-10 Finland
Pain in limb
1.2
15.0
2528
21824
M54.5
ICD-10 Finland
Low back pain
1.2
15.0
2430
20896
A10BX04
ATC
[U] exenatide; parenteral
3.4
14.9
73
219
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
14.9
5802
54344
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
14.9
1391
11207
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.2
14.8
2905
25468
SPAT1254
SPAT
Administration of medicine
1.4
14.8
721
5247
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.5
14.8
608
4282
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
2.6
14.8
105
403
LGA20
NOMESCO Finland
Sterilisation by constriction of Fallopian tubes
2.4
14.8
121
500
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
2.1
14.7
171
836
A10BD07
ATC
metformin and sitagliptin; systemic
2.1
14.6
171
837
C07AB08
ATC
celiprolol; oral
2.8
14.6
91
323
N02AJ06
ATC
codeine and paracetamol; systemic
1.2
14.6
2574
22317
63710
ICD-8 Finland
Pre-eclampsia, eclampsia and toxaemia, unspecified, Eclampsia
+∞
14.6
14
*
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
3.9
14.6
59
152
C10AX09
ATC
ezetimibe; oral
1.6
14.5
399
2574
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
1.8
14.5
253
1436
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.6
14.5
386
2469
J01FF01
ATC
clindamycin; systemic
1.3
14.4
1789
14917
SPAT1189
SPAT
Other ultrasound examination during pregnancy
1.7
14.4
312
1888
6542A
ICD-9 Finland
Abnormality of organs and soft tissues of pelvis, Previous Caesarean delivery[CICATRIX UTERI POSTOPERATIVA, RASKAUDEN AIKANA]
3.6
14.4
64
179
SPAT1312
SPAT
General health counselling
1.2
14.3
2261
19366
ACC51
NOMESCO Finland
Release of median nerve
1.5
14.2
510
3493
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.2
14.2
2580
22425
Z13.1
ICD-10 Finland
Special screening examination for diabetes mellitus
3.0
14.1
82
278
SGA01
NOMESCO Finland
Tooth opening as first aid
1.3
14.1
1198
9524
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
3.8
13.9
57
149
CL2S4
NOMESCO Finland
Ocular fundus photography for diabetic retinopathy screening
2.5
13.8
105
419
A10BG03
ATC
pioglitazone; oral
2.5
13.6
104
415
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
3.7
13.6
58
157
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
2.6
13.5
98
382
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.2
13.5
3009
26635
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
1.9
13.5
186
971
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.5
13.5
420
2786
C07AB05
ATC
betaxolol; oral
2.6
13.4
97
377
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.2
13.4
1998
16985
CKC15
NOMESCO Finland
Panretinal photocoagulation
3.9
13.4
54
139
C09DA07
ATC
telmisartan and diuretics; oral
1.9
13.2
182
951
A10AB06
ATC
insulin glulisine; parenteral
3.3
13.2
65
197
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
1.7
13.2
280
1686
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.5
13.0
459
3130
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
2.8
13.0
81
289
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.7
13.0
89
335
A02BC01
ATC
omeprazole; systemic
1.2
13.0
1688
14132
C03DA01
ATC
spironolactone; oral
1.5
12.9
385
2530
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
5.2
12.9
39
75
TMW99
NOMESCO Finland
Other minor surgical procedure in obstetrics
2.5
12.9
97
385
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.3
12.9
1107
8802
O32.1
ICD-10 Finland
Maternal care for breech presentation
1.5
12.9
423
2842
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
12.8
5511
51650
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
2.2
12.7
133
622
O99.5
ICD-10 Finland
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
2.7
12.7
87
327
Y6099
ICD-8 Finland
Prenatal care and observation
1.6
12.5
341
2199
O82.11
ICD-10 Finland
Childbirth with an emergency caesarean section in an emergency
2.2
12.4
120
541
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
5.0
12.4
39
79
B05DB
ATC
Hypertonic solutions
5.2
12.3
37
71
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
12.3
3781
34358
AA1AD
NOMESCO Finland
CT of head and brain
1.3
12.3
1051
8351
H03AA01
ATC
levothyroxine sodium; systemic
1.2
12.2
1839
15628
I25.2
ICD-10 Finland
Old myocardial infarction
2.4
12.2
100
418
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
1.8
12.2
225
1300
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
12.2
3886
35421
K04.0
ICD-10 Finland
Pulpitis
1.4
12.1
733
5537
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
3.4
12.0
56
164
O20.0
ICD-10 Finland
Threatened abortion
1.7
12.0
261
1583
66170
ICD-8 Finland
NA
3.9
12.0
48
124
A10BH05
ATC
linagliptin; oral
2.0
12.0
140
690
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.3
11.9
112
501
O67.0
ICD-10 Finland
Intrapartum haemorrhage with coagulation defect
46.7
11.9
14
*
FNA01
NOMESCO Finland
Anastomosis to coronary artery from internal mammary artery, one distal anastamosis
3.1
11.9
62
198
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.4
11.8
607
4455
H3600, E113
ICD-10 Finland
NA
4.0
11.8
46
116
SGC10
NOMESCO Finland
Covering pulpa of tooth
1.4
11.8
688
5162
MAW96
NOMESCO Finland
Other operation in pregnancy or at delivery
2.7
11.8
78
289
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.2
11.7
118
543
137
Kela drug reimbursment
Uraemia requiring dialysis
4.0
11.7
45
112
6563A
ICD-9 Finland
Other foetal and placental problems affecting management of mother, Foetal distress[ASPHYXIA FOETALIS, RASKAUDEN AIKANA]
4.9
11.7
37
76
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
11.6
1125
9086
2501B
ICD-9 Finland
Diabetes mellitus, Diabetes with ketoacidosis[DIABETES MELLITUS CUM KETOACIDOSI ,TYYPPI I]
4.5
11.6
40
90
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
2.4
11.5
92
380
O41.1
ICD-10 Finland
Infection of amniotic sac and membranes
2.4
11.5
94
392
H43.1
ICD-10 Finland
Vitreous haemorrhage
2.2
11.5
112
511
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.2
11.4
1947
16737
B05DA
ATC
Isotonic solutions
4.5
11.4
39
87
MBA04
NOMESCO Finland
Curettage of uterus after delivery
2.9
11.4
68
238
AN1
HP
Coronary angiography
1.6
11.3
266
1653
Z39.0
ICD-10 Finland
Care and examination immediately after delivery
2.2
11.3
112
512
C08CA10
ATC
nilvadipine; oral
2.6
11.2
78
297
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.6
11.1
292
1866
A10BJ01
ATC
exenatide; parenteral
3.1
11.1
59
191
Y4300
ICD-8 Finland
Preventive sterilization, Legal sterilization, medical reasons (illness or physical injury)
2.2
11.1
109
500
A46
ICD-10 Finland
Erysipelas
1.4
11.0
524
3796
O40
ICD-10 Finland
Polyhydramnios
2.1
10.9
115
542
A10BD03
ATC
metformin and rosiglitazone; systemic
3.3
10.9
53
161
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
10.9
136
688
N97.0
ICD-10 Finland
Female infertility associated with anovulation
1.7
10.9
206
1202
P01AB01
ATC
metronidazole; oral, rectal
1.2
10.9
3220
29064
Z36.8
ICD-10 Finland
Other antenatal screening
1.7
10.9
202
1172
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
1.5
10.9
420
2924
M65.3
ICD-10 Finland
Trigger finger
1.6
10.8
268
1688
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
1.7
10.8
224
1344
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.2
10.8
1500
12622
H3602, E103
ICD-10 Finland
NA
5.2
10.7
32
62
WW500
NOMESCO Finland
Blood transfusion
1.7
10.7
200
1162
C08DB01
ATC
diltiazem; oral
2.0
10.7
138
706
6610B
ICD-9 Finland
Abnormality of forces of labour, Primary uterine inertia
2.7
10.6
69
255
C09AA01
ATC
captopril; oral
3.5
10.6
47
133
O45.9
ICD-10 Finland
Premature separation of placenta, unspecified
3.7
10.6
45
123
SGC00
NOMESCO Finland
Local medication of root channels of tooth
1.3
10.6
767
5950
A10BB01
ATC
glibenclamide; oral
2.8
10.6
66
236
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.3
10.6
838
6584
G63.2
ICD-10 Finland
Diabetic polyneuropathy
6.0
10.5
28
47
H25.8
ICD-10 Finland
Other senile cataract
1.6
10.5
284
1828
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.9
10.5
148
784
F29
ICD-10 Finland
Unspecified nonorganic psychosis
0.5
10.5
81
1600
B01AB04
ATC
dalteparin; parenteral
1.6
10.5
238
1466
O61.1
ICD-10 Finland
Failed instrumental induction of labour
4.1
10.4
39
96
C02DE04
ATC
NA
3.5
10.2
46
133
O03.4
ICD-10 Finland
Spontaneous abortion, Incomplete, without complication
1.7
10.1
216
1304
B02AA02
ATC
tranexamic acid; systemic
1.2
10.1
1395
11720
FM1NE
NOMESCO Finland
Ultrasound examination of fetal heart
3.1
10.1
54
177
C02LM02
ATC
NA
4.4
10.1
35
80
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
1.9
10.0
138
726
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
2.0
10.0
118
584
G03GA01
ATC
chorionic gonadotrophin; parenteral
1.4
10.0
415
2934
SPAT1260
SPAT
Consultation of another employee
1.3
9.9
1070
8744
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
3.0
9.9
57
193
W05
ICPC
Pregnancy vomiting/nausea
2.3
9.9
90
399
J45.9
ICD-10 Finland
Asthma, unspecified
1.3
9.9
1084
8879
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
3.6
9.8
42
116
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
1.5
9.8
299
1981
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
9.8
459
3316
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3.3
9.8
48
148
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
9.7
496
3637
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
1.2
9.7
1944
16933
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.2
9.7
1615
13826
I20.01
ICD-10 Finland
Unstable angina
2.9
9.7
56
192
Z37.2
ICD-10 Finland
Twins, both liveborn
3.4
9.7
44
128
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.0
9.7
122
621
Z35
ICD-10 Finland
Supervision of high-risk pregnancy
2.2
9.7
99
463
O21.0
ICD-10 Finland
Mild hyperemesis gravidarum
2.1
9.7
101
475
Z49.2
ICD-10 Finland
Other dialysis
4.0
9.7
37
93
SPAT1283
SPAT
Restricted health certificate
1.2
9.7
1650
14161
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.3
9.6
702
5449
O47
ICD-10 Finland
False labour
2.3
9.6
85
370
I50.0
ICD-10 Finland
Congestive heart failure
2.0
9.6
111
547
A12AA04
ATC
calcium carbonate; oral
2.8
9.6
61
222
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
1.2
9.6
1196
9936
R09
ICPC
Sinus symptom/complaint
1.3
9.6
640
4907
C09BA03
ATC
lisinopril and diuretics; oral
2.3
9.6
82
353
H02AB06
ATC
prednisolone; systemic
1.2
9.5
3118
28281
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
2.3
9.5
85
374
ZXD08
NOMESCO Finland
NA
5.0
9.5
29
58
MA3AE
SPAT
NA
3.3
9.5
46
141
O36.3
ICD-10 Finland
Maternal care for signs of fetal hypoxia
2.7
9.5
64
242
A10BH02
ATC
vildagliptin; oral
2.5
9.4
68
269
MA3AE
NOMESCO Finland
Combined first trimester screening
1.4
9.3
375
2635
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
2.8
9.3
59
214
C09CA07
ATC
telmisartan; oral
1.5
9.3
295
1973
H66.9
ICD-10 Finland
Otitis media, unspecified
1.5
9.3
353
2452
B01AA03
ATC
warfarin; systemic
1.4
9.3
481
3542
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
2.5
9.2
70
282
J01MA02
ATC
ciprofloxacin; systemic
1.2
9.2
2223
19670
Z94.0
ICD-10 Finland
Kidney transplant status
2.9
9.2
54
189
L08
ICPC
Shoulder symptom/complaint
1.2
9.1
1071
8831
E66.0
ICD-10 Finland
Obesity due to excess calories
2.6
9.1
62
235
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.4
9.1
365
2565
O72.0
ICD-10 Finland
Third-stage haemorrhage
1.6
9.1
201
1231
A11CC03
ATC
alfacalcidol; systemic
2.2
9.1
90
416
A10BX01
ATC
guar gum; systemic
1.9
9.1
136
740
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.6
9.1
230
1460
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.4
9.0
407
2926
O36.4
ICD-10 Finland
Maternal care for intrauterine death
2.6
9.0
63
245
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.7
9.0
230
3395
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
4.7
9.0
29
62
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
2.9
9.0
53
186
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
6.5
8.9
22
34
N18.8
ICD-10 Finland
Other chronic renal failure
2.4
8.9
72
302
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
8.8
229
1465
N05AH03
ATC
olanzapine; systemic
0.6
8.8
170
2651
H3603, E113
ICD-10 Finland
NA
3.6
8.8
38
107
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.4
8.8
504
3774
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
8.8
158
913
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
8.8
5254
49676
6412B
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Premature separation of placenta[ABLATIO PLACENTAE ANTETEMPUS,SYNN PÄÄTT HOITOJAKSO]
4.1
8.7
32
78
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
1.9
8.7
127
684
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.3
8.7
940
7680
N03AX12
ATC
gabapentin; oral
1.3
8.7
906
7373
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
1.4
8.7
363
2571
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.5
8.7
319
2206
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
1.9
8.7
114
592
WZC30
NOMESCO Finland
Teaching
1.3
8.6
698
5497
I20.09
ICD-10 Finland
Unstable angina
1.9
8.6
124
666
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.2
8.6
1178
9878
XFE00
NOMESCO Finland
Epicardial ultrasonography
2.2
8.6
86
400
A10BJ05
ATC
dulaglutide; parenteral
2.9
8.6
50
174
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.1
8.6
3740
34562
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.4
8.5
374
2675
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.3
8.5
588
4528
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
0.3
8.5
19
605
O21
ICD-10 Finland
Excessive vomiting in pregnancy
2.3
8.5
72
309
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
3.1
8.5
45
148
A02BC02
ATC
pantoprazole; systemic
1.1
8.5
4533
42467
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.4
8.5
489
3668
SPAT1315
SPAT
Periodic health check-up of children and adolescents
1.5
8.5
277
1866
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
4.9
8.5
26
53
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
1.4
8.4
397
2878
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
1.3
8.4
781
6262
SPAT1192
SPAT
Gynaecological examination
1.2
8.4
974
8018
Z00.0
ICD-10 Finland
General medical examination
1.2
8.4
1057
8784
O26.7
ICD-10 Finland
Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
2.0
8.4
97
481
TPH04
NOMESCO Finland
Cathetrisation of vein
1.2
8.3
1092
9113
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.3
8.3
523
3976
A10BD08
ATC
metformin and vildagliptin; systemic
3.6
8.3
35
97
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
1.9
8.3
107
553
6510A
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]
3.0
8.3
45
151
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.1
8.2
3194
29259
8502
FHL
Evacuation and abrasion
1.4
8.1
376
2717
6466A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Infections of genito-urinary tract in pregnancy
3.6
8.1
34
94
O73.0
ICD-10 Finland
Retained placenta without haemorrhage
2.1
8.1
85
404
B01AC24
ATC
ticagrelor; oral
2.2
8.1
80
371
B01AF01
ATC
rivaroxaban; oral
1.4
8.0
412
3031
TLC00
NOMESCO Finland
Insertion of intrauterine device
1.3
8.0
667
5276
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
1.7
8.0
170
1032
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
5.2
8.0
23
44
K08.3
ICD-10 Finland
Retained dental root
1.5
8.0
287
1977
64399
ICD-8 Finland
Spontaneous abortion, Without mention of sepsis or toxaemia
1.5
7.9
250
1675
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.3
7.9
796
6451
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.3
7.8
501
3819
R06.0
ICD-10 Finland
Dyspnoea
1.2
7.8
1302
11125
J01EA01
ATC
trimethoprim; systemic
1.2
7.8
1938
17145
171
Kela drug reimbursment
Degludekinsuliini
3.1
7.8
40
130
SPAT1190
SPAT
Insertion or removal of intrauterine contraceptive device
1.3
7.7
579
4515
C10AA04
ATC
fluvastatin; oral
1.5
7.7
238
1588
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
2.4
7.7
63
266
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
1.6
7.6
208
1346
SGB30
NOMESCO Finland
Other demanding filling of root channel of tooth
1.2
7.6
832
6807
6598B
ICD-9 Finland
Other indications for care or intervention related to labour and delivery and not elsewhere classified, Other specified indications for care or intervention related to labour and delivery[INDICATIONES INTERVENTIONUM ALIAE ,SYNNYTYKSEN AIKA]
2.9
7.6
44
153
O85
ICD-10 Finland
Puerperal sepsis
2.0
7.5
86
426
82
HP
Single vessel balloon catheter extension
3.8
7.5
30
80
SGA04
NOMESCO Finland
Very demanding opening and dilatation of root canal of tooth
1.3
7.5
758
6144
S18
ICPC
Laceration/cut
1.2
7.5
2346
21116
EBA00
NOMESCO Finland
Extraction of tooth
1.2
7.5
2084
18596
B03BA03
ATC
hydroxocobalamin; parenteral
1.6
7.4
203
1317
358
Kela drug reimbursment
liraglutide
3.8
7.4
29
76
SPAT1255
SPAT
Intravenous administration of medicine
1.4
7.4
304
2149
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
2.2
7.4
71
327
XMA20
NOMESCO Finland
Early examination of pregnancy
1.9
7.4
106
570
O02.0
ICD-10 Finland
Blighted ovum and nonhydatidiform mole
1.4
7.3
293
2062
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
1.4
7.3
389
2882
6427A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Pre-eclampsia or eclampsia superimposed on pre-existing hypertension[PRAE-ECL SEU ECL CUM HYPERT ART,ENNEN SYNNYTYSTÄ]
+∞
7.3
7
*
6429A
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Unspecified hypertension complicating pregnancy, childbirth, or the puerperium[HYPERTENSIO GRAVIDARUM NUD,ENNEN SYNNYTYSTÄ]
+∞
7.3
7
*
6420A
ICD-9 Finland
NA
+∞
7.3
7
*
R75
ICPC
Sinusitis acute/chronic
1.4
7.3
340
2464
FNC20
NOMESCO Finland
Aorto-coronary venous bypass with two distal anastomoses
4.1
7.3
26
63
R03AC02
ATC
salbutamol; inhalant
1.1
7.3
4009
37470
ULC02
NOMESCO Finland
Hysteroscopy
1.3
7.3
429
3233
SPAT1240
SPAT
Therapeutic discussion
1.2
7.3
833
6851
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.3
7.3
548
4280
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
2.0
7.2
88
446
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.2
7.2
1027
8640
C08CA03
ATC
isradipine; systemic
3.0
7.2
38
126
Z11.3
ICD-10 Finland
Special screening examination for infections with a predominantly sexual mode of transmission
0.7
7.2
243
3408
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
3.1
7.2
36
115
C02EA03
ATC
NA
3.1
7.2
36
115
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
2.6
7.2
48
184
N05AH02
ATC
clozapine; systemic
0.4
7.2
25
655
SGC40
NOMESCO Finland
Restauration of tooth for rooth therapy
1.8
7.2
114
637
NHQ40
NOMESCO Finland
Amputation of toe
2.9
7.1
41
141
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
2.9
7.1
41
142
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.4
7.1
375
2773
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
1.6
7.1
154
941
SPAT1044
SPAT
Tympanometry
1.7
7.1
126
726
E10.09
ICD-10 Finland
Insulin-dependent diabetes mellitus - With coma
6.5
7.1
17
26
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.2
7.1
1178
10062
65580
ICD-8 Finland
Occipital presentation
3.0
7.1
38
128
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
2.3
7.1
62
272
R42
ICD-10 Finland
Dizziness and giddiness
1.2
7.1
1139
9702
W03
ICPC
Antepartum bleeding
2.2
7.0
70
326
R3110
NOMESCO Finland
Psychosocial training
1.7
7.0
138
820
OAB50
SPAT
NA
2.3
7.0
62
273
O24.3
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, unspecified
8.8
7.0
14
16
A10BB07
ATC
glipizide; oral
3.6
7.0
29
80
J01FA15
ATC
telithromycin; oral
1.3
7.0
682
5502
N05AX08
ATC
risperidone; systemic
0.7
7.0
176
2597
G43.9
ICD-10 Finland
Migraine, unspecified
1.3
6.9
498
3866
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
2.8
6.9
42
153
KAY20
NOMESCO Finland
NA
0.5
6.9
41
877
O75.7
ICD-10 Finland
Vaginal delivery following previous caesarean section
3.0
6.9
36
119
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
1.5
6.9
256
1776
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.3
6.9
530
4151
TK800
NOMESCO Finland
Hemodialysis
2.1
6.9
72
346
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.1
6.8
2217
19984
V252A
ICD-9 Finland
Contraceptive management, Sterilisation
1.3
6.8
617
4937
K04.4
ICD-10 Finland
Acute apical periodontitis of pulpal origin
1.3
6.8
512
3997
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.3
6.7
486
3770
A10AD04
ATC
insulin lispro; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
3.2
6.7
32
99
M54.4
ICD-10 Finland
Lumbago with sciatica
1.2
6.7
1083
9219
M14.6*E10.6
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic neuropathic
5.6
6.7
18
32
Z35.4
ICD-10 Finland
Supervision of pregnancy with grand multiparity
2.1
6.7
71
342
FN1CB
NOMESCO Finland
Coronary flow reserve measurement with pressure wire
2.3
6.7
55
236
SPAT1216
SPAT
Assessment of functional ability
1.3
6.7
621
4979
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.0
6.7
78
391
M10.9
ICD-10 Finland
Gout, unspecified
1.8
6.7
112
637
AN4
HP
Balloon angioplasty and drug eluding stent
2.2
6.7
63
288
WX408
NOMESCO Finland
General anesthesy, balanced
1.2
6.7
1604
14130
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.2
6.7
1052
8935
C09AA04
ATC
perindopril; oral
1.6
6.7
158
990
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.2
6.7
1813
16130
S97
ICPC
Chronic ulcer skin
1.6
6.7
161
1014
SPAT1325
SPAT
Vaccination
1.2
6.7
1844
16430
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
1.7
6.7
131
782
81
HP
Angiography of the heart and coronary arteries
1.9
6.6
94
506
F20.9
ICD-10 Finland
Schizophrenia, unspecified
0.4
6.6
27
660
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
2.5
6.6
47
186
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
1.6
6.6
172
1106
WYA40
NOMESCO Finland
Assessment of oral health and treatment needs for family expecting first child
1.6
6.6
144
883
B03XA02
ATC
darbepoetin alfa; parenteral
2.2
6.6
64
295
MBA96
NOMESCO Finland
Other removal of retained products of conception after delivery or abortion
1.6
6.6
179
1161
H3601, E113
ICD-10 Finland
NA
2.6
6.6
43
163
CKC10
NOMESCO Finland
Local photocoagulation of retina
2.2
6.6
64
296
M01AE01
ATC
ibuprofen; systemic, rectal
1.2
6.6
7462
72925
L03
ICPC
Low back symptom/complaint
1.2
6.5
1621
14317
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
3.7
6.5
26
70
Z13.5
ICD-10 Finland
Special screening examination for eye and ear disorders
2.6
6.5
43
164
A10BX09
ATC
[U] dapagliflozin; oral
2.6
6.5
43
164
O47.9
ICD-10 Finland
False labour, unspecified
1.7
6.5
138
840
W27
ICPC
Fear of complications of pregnancy
1.9
6.5
87
460
SPAT1308
SPAT
Sexual health counselling
1.2
6.5
1142
9800
WX704
NOMESCO Finland
Intubation
1.3
6.5
393
2976
O20.8
ICD-10 Finland
Other haemorrhage in early pregnancy
2.2
6.5
59
267
WX722
NOMESCO Finland
PEEP
1.6
6.5
154
968
L15
ICPC
Knee symptom/complaint
1.2
6.5
1214
10481
63500
ICD-8 Finland
Urinary infections arising during pregnancy and the puerperium, Pyelonephritis
2.4
6.5
50
209
Z95.5
ICD-10 Finland
Presence of coronary angioplasty implant and graft
2.2
6.4
61
281
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.5
6.4
176
1148
Z36.4
ICD-10 Finland
Antenatal screening for fetal growth retardation using ultrasound and other physical methods
1.7
6.4
127
762
J01FA06
ATC
roxithromycin; oral
1.1
6.4
2882
26537
J03.0
ICD-10 Finland
Streptococcal tonsillitis
1.5
6.4
204
1375
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
3.2
6.4
30
93
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
1.5
6.3
201
1352
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
3.7
6.3
25
67
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.3
6.3
567
4529
C07BB02
ATC
metoprolol and thiazides; systemic
2.4
6.3
50
212
6467A
ICD-9 Finland
Other complications of pregnancy, not elsewhere classified, Liver disorders in pregnancy[HEPATOSIS GRAVIDARUM]
2.2
6.3
57
255
O61.9
ICD-10 Finland
Failed induction of labour, unspecified
5.9
6.3
16
27
O68.3
ICD-10 Finland
Labour and delivery complicated by biochemical evidence of fetal stress
2.2
6.3
60
277
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
2.1
6.3
67
323
CL2L4
NOMESCO Finland
Wide-field fundus photography for diabetic retinopathy screening
5.5
6.3
17
31
A10BD20
ATC
metformin and empagliflozin; systemic
2.7
6.3
41
155
R5140
NOMESCO Finland
Monitoring the use of the aid
1.3
6.3
422
3248
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
1.8
6.3
93
511
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
1.7
6.3
127
765
R03.0
ICD-10 Finland
Elevated blood-pressure reading, without diagnosis of hypertension
1.5
6.3
232
1613
6424C
ICD-9 Finland
Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, SYNNYTYKSEN JÄLKEEN]
+∞
6.2
6
*
O10.3
ICD-10 Finland
Pre-existing hypertensive heart and renal disease complicating pregnancy, childbirth and the puerperium
+∞
6.2
6
*
O10.4
ICD-10 Finland
Pre-existing secondary hypertension complicating pregnancy, childbirth and the puerperium
+∞
6.2
6
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
1.5
6.2
174
1140
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
1.6
6.2
155
989
C09DB01
ATC
valsartan and amlodipine; oral
1.8
6.2
96
535
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
1.4
6.2
333
2478
6262A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Excessive or frequent menstruation[HYPERMENORRHOEA]
1.6
6.1
136
838
L70
ICD-10 Finland
Acne
0.5
6.1
36
769
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.2
6.1
788
6563
C10AA03
ATC
pravastatin; oral
1.5
6.1
202
1374
M01AE03
ATC
ketoprofen; systemic, rectal
1.1
6.0
2322
21143
SGA03
NOMESCO Finland
Demanding opening and dilatation of root canal of tooth
1.2
6.0
625
5086
Z49.0
ICD-10 Finland
Preparatory care for dialysis
2.8
6.0
35
124
A03
ICPC
Fever
1.2
6.0
1115
9613
Mortality – FinRegistry
↥Association
Association between endpoint O15_PREECLAMPS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_PREECLAMPS | 0.737 [0.61, 0.89] | 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.148 |
During the follow-up period (1.1.1998 — 31.12.2019), 168 out of 27833 females with O15_PREECLAMPS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_PREECLAMPS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.083% | No data |
| 5 | 0.476% | No data |
| 10 | 1.128% | No data |
| 15 | 2.111% | No data |
| 20 | 3.704% | No data |
Relationships between endpoints
↥Index endpoint: O15_PREECLAMPS – Pre-eclampsia
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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