No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersCheck mode of ICD-10 codes: %J300 Registry filters: 2 out of 7 registries used, show all original rules. |
2860 |
4. Check minimum number of eventsNone |
2860 |
5. Include endpointsNone |
2860 |
6. Filter based on genotype QC (FinnGen only) |
2860 |
Control definitions (FinnGen only)
- Control exclude
- ASTHMA_NOS
Extra metadata
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Vasomotor rhinitis (mode)
based on the number of shared cases.
Similar with more cases:
- Vasomotor and allergic rhinitis
- Other diseases of upper respiratory tract
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
- COPD differential diagnosis
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 18772 | 10965 | 7751 |
| Only index persons | 18144 | 10727 | 7417 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.31 | 0.22 |
| Only index persons | 0.35 | 0.39 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 46.83 | 47.11 | 46.47 |
| Only index persons | 46.74 | 47.05 | 46.29 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2860 | 1834 | 1026 |
| Unadjusted period prevalence (%) | 0.56 | 0.63 | 0.45 |
| Median age at first event (years) | 50.99 | 48.66 | 55.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2560
- Matched controls
- 25597
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R01AD09
ATC
mometasone; nasal
5.5
323.0
1868
8395
J30.0
ICD-10 Finland
Vasomotor rhinitis
4503599627370496.0
323.0
2558
94
R01AD08
ATC
fluticasone; nasal
4.7
272.8
1338
4878
J31.0
ICD-10 Finland
Chronic rhinitis
7.4
221.6
583
978
R01AD12
ATC
fluticasone furoate; nasal
3.4
167.7
1169
5104
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
3.6
160.3
915
3389
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.7
152.9
424
737
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.4
125.6
417
895
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.5
123.1
489
1270
J34.2
ICD-10 Finland
Deviated nasal septum
6.5
119.0
334
580
R01BA52
ATC
pseudoephedrine, combinations; oral
2.8
117.1
1095
5444
R03DC03
ATC
montelukast; oral
3.4
115.9
667
2381
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.5
111.7
313
540
R01AD01
ATC
beclometasone; nasal
3.4
111.1
644
2302
R01AX03
ATC
ipratropium bromide; nasal
11.5
108.9
211
199
DHB50
NOMESCO Finland
Turbinoplasty
9.2
105.8
231
272
XQ800
NOMESCO Finland
Prick test
4.5
98.4
385
969
R01AD05
ATC
budesonide; nasal
4.3
96.4
392
1023
R06AX27
ATC
desloratadine; oral
2.6
95.5
929
4584
R01AD11
ATC
triamcinolone; nasal
3.9
90.0
413
1200
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.7
89.3
772
3528
R03AC02
ATC
salbutamol; inhalant
2.3
86.2
1534
10125
H02AB06
ATC
prednisolone; systemic
2.2
80.3
1357
8620
J45.9
ICD-10 Finland
Asthma, unspecified
2.8
76.5
588
2468
J30.3
ICD-10 Finland
Other allergic rhinitis
6.5
76.5
209
344
J01AA02
ATC
doxycycline; systemic
2.5
75.8
2109
16681
J01FA10
ATC
azithromycin; systemic
2.1
70.4
1647
11755
DJD20
NOMESCO Finland
Plastic repair of septum of nose
5.6
66.4
206
397
R06AE07
ATC
cetirizine; oral
2.1
65.0
1278
8362
J34.3
ICD-10 Finland
Hypertrophy of nasal turbinates
8.3
64.9
149
189
A02BC05
ATC
esomeprazole; systemic
2.0
62.3
1158
7364
J45.1
ICD-10 Finland
Nonallergic asthma
3.8
61.1
285
825
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
61.0
1415
9788
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
6.6
56.7
151
239
TDM10
NOMESCO Finland
Puncture of maxillary antrum
4.9
54.3
186
400
ZXC60
NOMESCO Finland
Application of heat
8.6
53.3
119
144
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.0
52.5
224
598
UDM02
NOMESCO Finland
Sinoscopy
7.4
52.0
128
181
J01CA04
ATC
amoxicillin; systemic
2.1
51.2
2114
17617
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.3
50.9
560
2779
R06AE09
ATC
levocetirizine; oral
2.4
50.1
485
2256
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
6.5
50.1
135
217
R06.0
ICD-10 Finland
Dyspnoea
2.1
49.0
691
3829
R03BA02
ATC
budesonide; inhalant
2.3
48.1
528
2609
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
47.0
618
3312
R05
ICD-10 Finland
Cough
2.2
46.4
575
3000
R06AX22
ATC
ebastine; oral
2.2
45.9
538
2736
R03BA05
ATC
fluticasone; inhalant
2.2
45.2
533
2714
A02BC03
ATC
lansoprazole; oral
1.9
44.0
809
4934
J01FA09
ATC
clarithromycin; systemic
1.9
43.7
891
5642
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.9
42.7
290
1095
H02AB04
ATC
methylprednisolone; systemic
2.3
41.9
437
2092
M03BX02
ATC
tizanidine; oral
1.8
40.4
1614
12592
R03AC03
ATC
terbutaline; inhalant
2.3
39.3
420
2027
R09
ICPC
Sinus symptom/complaint
2.8
39.1
266
1003
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
4.4
39.1
148
352
R06AX13
ATC
loratadine; oral
2.2
38.9
473
2424
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
38.9
1132
7974
J33.8
ICD-10 Finland
Other polyp of sinus
7.5
38.2
92
126
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.9
37.0
719
4420
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.1
36.9
151
387
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
4.3
36.8
144
354
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
35.2
746
4708
J01FA06
ATC
roxithromycin; oral
1.7
34.4
1042
7336
J33.0
ICD-10 Finland
Polyp of nasal cavity
5.2
33.3
106
210
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
33.1
1031
7295
N02BE01
ATC
paracetamol; systemic, rectal
1.9
33.0
2164
18982
J01DB01
ATC
cefalexin; oral
1.8
32.8
2062
17800
A02BC02
ATC
pantoprazole; systemic
1.7
32.4
1612
12955
R03BA01
ATC
beclometasone; inhalant
2.1
32.3
405
2090
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
32.0
637
3914
R06.5
ICD-10 Finland
Mouth breathing
2.5
31.2
267
1146
G47.3
ICD-10 Finland
Sleep apnoea
1.9
31.0
550
3243
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
30.7
895
6176
XG474
NOMESCO Finland
Exhalation nntrogen oxide
4.6
30.7
110
248
A02BA02
ATC
ranitidine; systemic
1.9
30.6
507
2914
J02AC01
ATC
fluconazole; systemic
1.6
30.2
1064
7731
R03AK07
ATC
formoterol and budesonide; inhalant
1.9
29.6
507
2944
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
29.3
353
1785
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
6.4
29.2
78
125
UJF32
NOMESCO Finland
Coloscopy
1.8
28.9
643
4075
A02BC01
ATC
omeprazole; systemic
1.7
28.6
706
4617
R51.80
ICD-10 Finland
Headache
2.0
27.3
399
2176
N03AX12
ATC
gabapentin; oral
2.0
26.9
411
2282
J45
ICD-10 Finland
Asthma
2.3
26.0
270
1271
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.8
26.0
174
647
N03AX16
ATC
pregabalin; oral
1.7
25.6
590
3756
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.2
25.5
274
1310
M79.6
ICD-10 Finland
Pain in limb
1.6
25.5
875
6231
R03BA08
ATC
ciclesonide; inhalant
2.4
25.4
239
1074
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.2
25.2
274
1316
J01DA01
ATC
[U] cefalexin; systemic
1.6
25.0
1547
12697
R96
ICPC
Asthma
2.3
24.7
245
1129
M25.5
ICD-10 Finland
Pain in joint
1.7
24.6
718
4888
J32.2
ICD-10 Finland
Chronic ethmoidal sinusitis
8.3
24.4
54
66
J32.4
ICD-10 Finland
Chronic pansinusitis
7.0
24.2
60
87
J34.1
ICD-10 Finland
Cyst and mucocele of nose and nasal sinus
5.6
24.0
71
130
M54.5
ICD-10 Finland
Low back pain
1.6
23.9
808
5711
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.9
23.7
375
2099
M01AH05
ATC
etoricoxib; oral
1.5
23.6
1451
11809
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.0
23.4
141
490
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
23.4
281
1411
XG410
NOMESCO Finland
Flow-volume spirometry
3.2
23.2
128
419
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.0
23.1
347
1904
A02BC04
ATC
rabeprazole; oral
2.2
22.9
238
1120
Z00.0
ICD-10 Finland
General medical examination
1.8
22.6
459
2796
R03BC03
ATC
nedocromil; inhalant
2.4
22.4
204
901
R53
ICD-10 Finland
Malaise and fatigue
1.7
21.8
474
2949
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.2
21.1
225
1068
R06.2
ICD-10 Finland
Wheezing
2.9
21.1
129
454
S01GX01
ATC
cromoglicic acid; ophthalmic
1.7
21.0
515
3314
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
21.0
260
1321
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
6.4
21.0
55
87
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.0
20.8
289
1536
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
20.4
1107
8649
R05FA02
ATC
opium derivatives and expectorants; systemic
1.5
19.9
978
7468
M01AE02
ATC
naproxen; oral, rectal
1.5
19.9
1386
11391
SPAT1263
SPAT
Sampling
1.5
19.8
1014
7807
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
19.8
982
7511
R03AK08
ATC
formoterol and beclometasone; inhalant
3.1
19.8
113
379
UDC00
NOMESCO Finland
Ear microscopy
2.3
19.7
197
910
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.6
19.6
144
567
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.3
19.6
190
864
ZXA10
NOMESCO Finland
Bilateral
1.7
19.4
434
2713
M03BC51
ATC
orphenadrine, combinations; systemic
1.6
19.1
686
4864
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
18.8
609
4208
L03
ICPC
Low back symptom/complaint
1.6
18.6
565
3840
R75
ICPC
Sinusitis acute/chronic
2.6
18.6
135
528
SPAT1310
SPAT
Counselling related to known health issue
1.5
18.5
760
5552
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
18.4
679
4841
J01FA15
ATC
telithromycin; oral
1.9
18.2
267
1448
J35.0
ICD-10 Finland
Chronic tonsillitis
2.5
18.2
145
597
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
3.1
18.2
103
342
N06AX21
ATC
duloxetine; oral
1.9
18.2
276
1516
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
18.1
530
3566
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
18.0
410
2569
J45.8
ICD-10 Finland
Mixed asthma
3.4
18.0
87
259
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
17.9
546
3709
SPAT1301
SPAT
No procedures
1.5
17.8
729
5316
R01AC02
ATC
levocabastine; nasal
3.2
17.7
94
301
K07.60
ICD-10 Finland
Snapping jaw
2.5
17.6
139
570
E0000UV
ATC
NA
1.5
17.6
935
7202
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
17.5
348
2095
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
17.5
552
3781
SPAT1153
SPAT
Removal of sutures
1.5
17.5
743
5454
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
17.4
323
1901
R07
ICPC
Sneezing/nasal congestion
2.3
17.4
166
752
G44.2
ICD-10 Finland
Tension-type headache
1.8
17.3
341
2043
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
17.3
1696
14715
R01BA51
ATC
phenylpropanolamine, combinations; oral
1.8
17.1
293
1682
SPAT1312
SPAT
General health counselling
1.5
16.9
750
5553
M54.2
ICD-10 Finland
Cervicalgia
2.2
16.8
181
865
N02AX02
ATC
tramadol; systemic, rectal
1.4
16.7
965
7538
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
2.3
16.7
161
730
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.4
16.7
150
659
R06AX26
ATC
fexofenadine; oral
2.2
16.6
178
850
J30
ICD-10 Finland
Vasomotor and allergic rhinitis
4.7
16.6
56
121
R08
ICPC
Nose symptom/complaint other
3.1
16.6
91
299
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.7
16.5
388
2453
L17
ICPC
Foot/toe symptom/complaint
1.5
16.3
570
3994
S18
ICPC
Laceration/cut
1.4
16.2
946
7399
M01AB05
ATC
diclofenac; systemic, rectal
1.4
15.9
1610
13923
K30
ICD-10 Finland
Functional dyspepsia
1.9
15.9
256
1436
XQ802
NOMESCO Finland
Epicutan test
2.6
15.7
117
465
R07.0
ICD-10 Finland
Pain in throat
2.2
15.6
161
756
J46
ICD-10 Finland
Status asthmaticus
3.4
15.4
76
231
M01AC06
ATC
meloxicam; systemic, rectal
1.4
15.3
863
6681
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
15.3
1251
10376
C05AA08
ATC
fluocortolone; rectal, topical
1.7
15.1
337
2093
R05
ICPC
Cough
1.5
15.0
517
3601
M48.0
ICD-10 Finland
Spinal stenosis
1.8
15.0
268
1555
A07AA02
ATC
nystatin; oral
2.2
14.8
151
704
J31
ICD-10 Finland
Chronic rhinitis, nasopharyngitis and pharyngitis
5.5
14.8
43
79
N02AJ06
ATC
codeine and paracetamol; systemic
1.4
14.7
850
6600
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
14.6
390
2548
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
14.6
1141
9358
R21
ICPC
Throat symptom/complaint
1.6
14.5
451
3062
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.6
14.4
369
2383
R05FB02
ATC
cough suppressants and expectorants
1.4
14.4
859
6704
J01.9
ICD-10 Finland
Acute sinusitis, unspecified
2.7
14.4
101
389
J01MA02
ATC
ciprofloxacin; systemic
1.4
14.3
853
6657
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
2.5
14.2
108
435
J01DC02
ATC
cefuroxime; systemic
2.2
14.1
148
699
R01BA01
ATC
phenylpropanolamine; oral
2.2
14.1
141
654
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.8
14.1
246
1417
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
14.0
860
6736
R03AC13
ATC
formoterol; inhalant
2.3
14.0
127
561
A01AB09
ATC
miconazole; local oral
1.9
14.0
214
1177
N05CF01
ATC
zopiclone; oral
1.4
13.8
707
5345
R74
ICPC
Upper respiratory infection acute
1.5
13.8
646
4799
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
9.1
13.7
28
31
P01AB01
ATC
metronidazole; oral, rectal
1.4
13.7
923
7349
SPAT1058
SPAT
PEF monitoring instruction
1.9
13.6
200
1084
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
13.6
1515
13131
M79.1
ICD-10 Finland
Myalgia
1.7
13.3
300
1869
R03BB04
ATC
tiotropium bromide; inhalant
1.9
13.1
206
1144
A01AB04
ATC
amphotericin B; local oral
2.3
13.1
118
520
G04CA02
ATC
tamsulosin; oral
1.6
12.9
396
2672
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.5
12.9
600
4446
M01AH02
ATC
rofecoxib; oral
1.7
12.5
290
1818
C07AB07
ATC
bisoprolol; oral
1.4
12.4
981
7986
N05BA04
ATC
oxazepam; oral
1.5
12.4
546
3995
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.4
12.4
721
5563
J01DA06
ATC
[U] cefuroxime; systemic
1.6
12.3
339
2226
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
12.1
895
7199
N06AX11
ATC
mirtazapine; oral
1.4
12.1
703
5422
DHB20
NOMESCO Finland
Polypectomy of internal nose
4.6
12.0
41
91
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.7
12.0
258
1585
J01FF01
ATC
clindamycin; systemic
1.4
11.9
609
4584
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
11.9
630
4773
J01
ICD-10 Finland
Acute sinusitis
2.2
11.9
116
533
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.7
11.8
245
1487
R49.01
ICD-10 Finland
Functional dysphonia
2.7
11.8
82
315
L08
ICPC
Shoulder symptom/complaint
1.5
11.7
414
2884
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
11.7
514
3751
D07AC01
ATC
betamethasone; topical
1.4
11.7
739
5777
M02AA07
ATC
piroxicam; topical
1.4
11.6
817
6504
N06AA09
ATC
amitriptyline; systemic
1.7
11.6
230
1380
SPAT1059
SPAT
Spirometry at the office
2.1
11.6
124
594
KMAK
NOMESCO Finland
NA
1.3
11.6
1208
10244
J05AB01
ATC
aciclovir; systemic
1.5
11.6
478
3448
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
11.5
920
7479
J01MA14
ATC
moxifloxacin; systemic
1.8
11.5
197
1127
N06AB04
ATC
citalopram; systemic
1.5
11.5
482
3489
R03AC12
ATC
salmeterol; inhalant
2.3
11.5
102
448
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
4.9
11.4
36
74
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.5
11.4
433
3065
M54
ICD-10 Finland
Dorsalgia
1.7
11.4
249
1537
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.5
11.4
90
373
M70.6
ICD-10 Finland
Trochanteric bursitis
1.7
11.3
269
1697
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.5
11.2
379
2611
DPA30
NOMESCO Finland
Sphenotomy
7.3
11.2
26
36
G50.1
ICD-10 Finland
Atypical facial pain
3.4
11.2
52
153
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
3.9
11.1
45
118
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
11.1
382
2643
-1
NOMESCO Finland
NA
1.4
11.0
748
5906
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.6
11.0
274
1754
G04CB02
ATC
dutasteride; oral
2.2
10.9
116
552
R52.9
ICD-10 Finland
Pain, unspecified
1.8
10.9
187
1072
R49.08
ICD-10 Finland
Other specified dysphonia
3.0
10.9
60
201
UKC02
NOMESCO Finland
Cystoscopy
1.6
10.8
316
2104
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
10.8
918
7509
J47
ICD-10 Finland
Bronchiectasis
3.6
10.8
48
137
M01AX17
ATC
nimesulide; oral
1.4
10.7
551
4137
N41.1
ICD-10 Finland
Chronic prostatitis
3.3
10.7
53
164
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
2.5
10.7
82
332
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.1
10.7
115
551
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.4
10.7
609
4659
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.3
10.7
1109
9357
EMB10
NOMESCO Finland
Tonsillectomy
2.0
10.6
130
657
J01MA12
ATC
levofloxacin; systemic
1.5
10.6
379
2642
DHW99
NOMESCO Finland
Other operation on nose
60.2
10.6
12
*
J01AA04
ATC
lymecycline; systemic
1.6
10.6
288
1886
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.6
10.5
307
2044
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
10.5
692
5431
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
10.5
662
5155
G04CA01
ATC
alfuzosin; oral
1.7
10.4
205
1224
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.9
10.4
153
834
A06AC51
ATC
ispaghula, combinations; systemic
2.0
10.3
122
611
J34.8
ICD-10 Finland
Other specified disorders of nose and nasal sinuses
4.3
10.3
37
88
R13
ICD-10 Finland
Dysphagia
1.9
10.2
143
763
A03FA02
ATC
cisapride; oral, rectal
1.8
10.1
171
976
XF402
NOMESCO Finland
ECG with work load test
1.7
10.1
233
1458
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.7
10.1
202
1215
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
10.0
351
2435
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.8
10.0
161
901
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.6
10.0
234
1472
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.6
10.0
245
1561
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.7
10.0
186
1097
H13
ICPC
Plugged feeling ear
1.5
9.8
360
2523
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.0
9.8
130
680
H02AB07
ATC
prednisone; oral
1.5
9.8
307
2081
R03DC01
ATC
zafirlukast; oral
3.4
9.8
45
133
WZA90
NOMESCO Finland
Other doctors statement
1.4
9.7
501
3760
A03CA02
ATC
clidinium and psycholeptics; oral
2.0
9.7
129
675
XQ809
NOMESCO Finland
NA
55.2
9.6
11
*
R5140
NOMESCO Finland
Monitoring the use of the aid
1.7
9.6
212
1312
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.3
9.5
89
400
J01CE02
ATC
phenoxymethylpenicillin; oral
1.3
9.4
1596
14320
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
9.4
220
1384
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
1.8
9.4
161
924
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
3.5
9.3
42
122
R03AK11
ATC
formoterol and fluticasone; inhalant
2.7
9.3
60
223
N05CF02
ATC
zolpidem; oral
1.5
9.3
390
2811
XF404
NOMESCO Finland
Ambulatory ECG
1.7
9.3
190
1151
K02.1
ICD-10 Finland
Caries of dentine
1.3
9.2
1289
11248
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
9.2
97
464
M01AG02
ATC
tolfenamic acid; oral, rectal
1.5
9.2
349
2465
L50.3
ICD-10 Finland
Dermatographic urticaria
3.2
9.0
46
147
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
9.0
853
7044
G43.9
ICD-10 Finland
Migraine, unspecified
1.9
9.0
130
703
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
3.1
9.0
47
153
L01
ICPC
Neck symptom/complaint
1.5
9.0
292
1994
R03DA04
ATC
theophylline; systemic, rectal
2.1
8.9
98
477
L15
ICPC
Knee symptom/complaint
1.4
8.9
440
3269
M01AE01
ATC
ibuprofen; systemic, rectal
1.4
8.9
2190
20669
N40
ICD-10 Finland
Hyperplasia of prostate
1.5
8.9
335
2362
H92.0
ICD-10 Finland
Otalgia
2.0
8.9
115
598
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.5
8.8
67
274
M01AX01
ATC
nabumetone; oral
2.0
8.8
103
514
M02AA10
ATC
ketoprofen; topical
1.5
8.8
329
2317
E000001
ATC
NA
1.4
8.7
440
3281
R02
ICPC
Shortness of breath/dyspnoea
1.6
8.7
241
1584
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
1.7
8.7
164
969
M03BC01
ATC
orphenadrine (citrate); systemic
1.4
8.7
537
4150
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.9
8.7
129
705
SPAT1260
SPAT
Consultation of another employee
1.4
8.7
379
2750
D07CC01
ATC
betamethasone and antibiotics; topical
1.5
8.6
274
1858
M75
ICD-10 Finland
Shoulder lesions
2.1
8.6
95
462
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
2.4
8.6
72
309
XKC03
NOMESCO Finland
Water cystometry
2.3
8.6
76
337
XCC00
NOMESCO Finland
Investigative irrigation of lacrimal passages
3.6
8.5
36
100
H01
ICPC
Ear pain/earache
1.6
8.4
224
1456
SPAT1081
SPAT
Cardiorespiratory global assessment
1.9
8.4
115
610
A02BA04
ATC
nizatidine; systemic
1.7
8.4
161
956
ENC30
NOMESCO Finland
Plastic operation of pharynx
3.5
8.4
37
107
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.4
8.3
401
2963
F45.8
ICD-10 Finland
Other somatoform disorders
1.8
8.3
150
873
C09CA06
ATC
candesartan; oral
1.4
8.3
447
3369
H29
ICPC
Ear symptom/complaint other
1.6
8.3
203
1292
K59.09
ICD-10 Finland
Constipation, unspecified
1.9
8.3
116
620
H02
ICPC
Hearing complaint
1.6
8.3
229
1506
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.8
8.2
146
849
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
1.8
8.2
135
766
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
8.2
228
1502
R01AC01
ATC
cromoglicic acid; nasal
2.1
8.2
90
440
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.5
8.1
264
1802
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
8.1
946
8018
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
8.1
1239
10867
SBB10
NOMESCO Finland
Teeth copy
1.8
8.1
132
748
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
8.1
620
4951
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
4.8
8.1
25
52
J32.1
ICD-10 Finland
Chronic frontal sinusitis
6.3
8.0
20
32
F51.0
ICD-10 Finland
Nonorganic insomnia
1.5
8.0
271
1868
R51.81
ICD-10 Finland
Facial pain NOS
2.6
8.0
53
203
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.6
7.9
219
1436
M01AX05
ATC
glucosamine; oral
1.4
7.9
393
2917
UJH02
NOMESCO Finland
Anoscopy
2.1
7.9
90
444
XKD00
NOMESCO Finland
Uroflowmetry
1.5
7.9
278
1928
S01GX02
ATC
levocabastine; ophthalmic
1.8
7.9
139
808
H03AA01
ATC
levothyroxine sodium; systemic
1.4
7.9
500
3878
M02AA15
ATC
diclofenac; topical (antiinflammatory prep., non-steroids for topical use)
1.7
7.8
159
963
R20.2
ICD-10 Finland
Paraesthesia of skin
1.7
7.8
144
849
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.5
7.8
284
1988
R01AD
ATC
Corticosteroids
3.4
7.8
35
103
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.6
7.8
185
1170
R05DA01
ATC
ethylmorphine; oral
1.7
7.8
169
1045
C07AA05
ATC
propranolol; systemic
1.4
7.8
416
3133
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.6
7.7
198
1279
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
7.6
412
3105
L82
ICD-10 Finland
Seborrhoeic keratosis
1.4
7.6
316
2271
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
1.9
7.6
109
593
SPAT1325
SPAT
Vaccination
1.3
7.6
710
5831
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
7.5
1295
11479
AN1
HP
Coronary angiography
1.6
7.5
207
1361
Z01.2
ICD-10 Finland
Dental examination
1.3
7.5
899
7623
H66.9
ICD-10 Finland
Otitis media, unspecified
1.8
7.5
114
632
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
7.5
322
2329
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.3
7.4
963
8241
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
2.0
7.4
95
492
Z00.8
ICD-10 Finland
Other general examinations
1.7
7.4
147
884
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.6
7.4
189
1218
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
2.3
7.4
62
269
D06AX01
ATC
fusidic acid; topical (antibiotics for topical use)
1.6
7.4
207
1364
J37.0
ICD-10 Finland
Chronic laryngitis
2.1
7.4
77
369
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.6
7.3
191
1235
H25.8
ICD-10 Finland
Other senile cataract
1.6
7.3
174
1102
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.6
7.3
164
1021
J31.1
ICD-10 Finland
Chronic nasopharyngitis
4.2
7.3
26
63
K60.1
ICD-10 Finland
Chronic anal fissure
2.5
7.3
55
227
A03
ICPC
Fever
1.4
7.3
314
2273
J20
ICD-10 Finland
Acute bronchitis
1.6
7.2
198
1299
C10AA03
ATC
pravastatin; oral
1.7
7.2
135
797
R01AC03
ATC
azelastine; nasal
5.8
7.2
19
33
N02CC04
ATC
rizatriptan; oral
1.7
7.2
129
754
L16
ICPC
Ankle symptom/complaint
1.6
7.1
201
1327
SAA04
NOMESCO Finland
Special inverstigation of mouth
1.8
7.1
120
689
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
1.9
7.1
97
518
R15
ICD-10 Finland
Faecal incontinence
2.4
7.1
59
254
M77.1
ICD-10 Finland
Lateral epicondylitis
1.7
7.0
150
919
D01
ICPC
Abdominal pain/cramps general
1.5
7.0
218
1472
H53.1
ICD-10 Finland
Subjective visual disturbances
1.7
7.0
135
805
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
2.1
7.0
75
364
C10AA07
ATC
rosuvastatin; oral
1.3
7.0
471
3676
R50.9
ICD-10 Finland
Fever, unspecified
1.5
7.0
270
1908
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.4
7.0
367
2751
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
7.0
542
4324
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.8
7.0
124
721
R00.2
ICD-10 Finland
Palpitations
1.7
7.0
141
852
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.5
6.9
240
1663
J01DC04
ATC
cefaclor; oral
3.0
6.9
37
125
R29
ICPC
Respiratory symptom/complaint other
1.7
6.9
127
750
DHB40
NOMESCO Finland
Conchotomy
13.8
6.9
11
8
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
1.7
6.9
140
848
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.6
6.9
180
1166
D06BX01
ATC
metronidazole; topical
1.5
6.9
219
1490
L02
ICPC
Back symptom/complaint
1.6
6.9
180
1168
N81.6
ICD-10 Finland
Rectocele
1.7
6.9
137
829
AA1AD
NOMESCO Finland
CT of head and brain
1.3
6.8
455
3547
4226
FHL
Posterior radical surgery and possible etmoidectomy
4.8
6.8
21
44
J32
ICD-10 Finland
Chronic sinusitis
4.8
6.8
21
44
L57.0
ICD-10 Finland
Actinic keratosis
1.6
6.8
172
1105
D07AC13
ATC
mometasone; topical
1.3
6.8
598
4856
R35
ICD-10 Finland
Polyuria
1.8
6.8
119
691
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.5
6.8
269
1916
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.6
6.8
190
1253
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
6.7
327
2416
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
1.8
6.7
115
663
R07.3
ICD-10 Finland
Other chest pain
1.6
6.7
183
1198
SPAT1097
SPAT
Recording of ECG
1.4
6.7
292
2114
H25.0
ICD-10 Finland
Senile incipient cataract
1.8
6.7
111
634
SPAT1202
SPAT
Intra-articular injection
2.1
6.7
72
349
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
1.9
6.7
96
523
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.6
6.7
150
935
207
Kela drug reimbursment
Chronic arrhythmias
1.5
6.7
248
1739
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.5
6.6
242
1694
S83.2
ICD-10 Finland
Tear of meniscus, current
1.7
6.6
141
865
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
2.0
6.6
80
407
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.4
6.5
316
2339
J01DA08
ATC
[U] cefaclor; oral
1.5
6.5
233
1627
ENC40
NOMESCO Finland
Uvulopalatopharyngoplasty
3.6
6.5
27
76
SPAT1193
SPAT
Pap smear
1.5
6.5
197
1328
R42
ICD-10 Finland
Dizziness and giddiness
1.3
6.5
433
3379
H69.0
ICD-10 Finland
Patulous Eustachian tube
5.3
6.5
18
34
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.3
6.5
540
4353
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
1.8
6.4
97
535
L86
ICPC
Back syndrome with radiating pain
1.7
6.4
114
666
N04BC05
ATC
pramipexole; oral
1.6
6.4
144
898
WX110
NOMESCO Finland
Local anesthesy
1.2
6.4
1569
14358
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.4
6.4
344
2592
R03BB01
ATC
ipratropium bromide; inhalant
2.0
6.4
72
358
D20
ICPC
Mouth/tongue/lip symptom/complaint
1.9
6.3
87
467
C08DA01
ATC
verapamil; systemic
1.9
6.3
81
424
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.7
6.3
123
736
K59.0
ICD-10 Finland
Constipation
1.8
6.3
107
616
R60.0
ICD-10 Finland
Localized oedema
1.5
6.3
203
1384
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.7
6.3
131
803
DM1ZD
NOMESCO Finland
NA
+∞
6.3
6
*
H26.4
ICD-10 Finland
After-cataract
1.6
6.2
150
952
M13.9
ICD-10 Finland
Arthritis, unspecified
1.6
6.2
139
867
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.3
6.2
571
4657
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
1.9
6.2
90
493
T78.4
ICD-10 Finland
Allergy, unspecified
1.8
6.2
95
527
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.3
6.2
519
4181
G04BD12
ATC
mirabegron; oral
1.5
6.2
192
1298
SDA02
NOMESCO Finland
Parodonthologic therapy
1.3
6.2
678
5657
T81.9
ICD-10 Finland
Unspecified complication of procedure
2.6
6.2
41
159
H04.5
ICD-10 Finland
Stenosis and insufficiency of lacrimal passages
2.4
6.1
48
203
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.6
6.1
160
1036
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
1.5
6.1
233
1647
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.3
6.1
521
4206
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.6
6.1
155
999
C05AA01
ATC
hydrocortisone; rectal, topical
1.8
6.1
102
586
K59.1
ICD-10 Finland
Functional diarrhoea
1.8
6.1
96
538
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
12.5
6.1
10
8
J01FA01
ATC
erythromycin; systemic
1.4
6.1
294
2171
K03.00
ICD-10 Finland
Approximal wear
1.8
6.1
98
556
M54.6
ICD-10 Finland
Pain in thoracic spine
1.6
6.1
136
851
XJH00
NOMESCO Finland
Transanal ultrasonography
1.7
6.1
112
660
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
6.0
219
1533
M75.8
ICD-10 Finland
Other shoulder lesions
2.0
6.0
72
368
R30.1
ICD-10 Finland
Vesical tenesmus
2.7
6.0
39
147
Mortality – FinRegistry
↥Association
Association between endpoint RHINITIS_VASOMOTOR and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHINITIS_VASOMOTOR | 0.877 [0.78, 0.98] | 0.021 |
| Birth year | 0.999 [0.99, 1.01] | 0.818 |
During the follow-up period (1.1.1998 — 31.12.2019), 736 out of 10047 females with RHINITIS_VASOMOTOR died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHINITIS_VASOMOTOR | 0.866 [0.77, 0.97] | 0.011 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 835 out of 7091 males with RHINITIS_VASOMOTOR died.
Mortality risk
Mortality risk for people of age
years, who have RHINITIS_VASOMOTOR.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.106% | 0.16% |
| 5 | 0.563% | 0.996% |
| 10 | 1.343% | 2.368% |
| 15 | 2.626% | 4.437% |
| 20 | 4.741% | 7.455% |
Relationships between endpoints
↥Index endpoint: RHINITIS_VASOMOTOR – Vasomotor rhinitis (mode)
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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