choroid cancer: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2095 |
4. Check minimum number of eventsNone |
2095 |
5. Include endpointsNone |
2095 |
6. Filter based on genotype QC (FinnGen only) |
2095 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D31
- Name in latin
- Neoplasma benignum chorioideae
Similar endpoints
↥List of similar endpoints to Benign neoplasm: Choroid based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Choroid
- Benign neoplasm of eye and adnexa
- Benign neoplasm of eye and adnexa
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 11875 | 7347 | 4502 |
Only index persons | 11506 | 7160 | 4346 |
Unadjusted period prevalence (%) | |||
Whole population | 0.18 | 0.21 | 0.13 |
Only index persons | 0.23 | 0.26 | 0.17 |
Median age at first event (years) | |||
Whole population | 65.87 | 65.27 | 66.87 |
Only index persons | 65.71 | 65.12 | 66.70 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 2095 | 1271 | 824 |
Unadjusted period prevalence (%) | 0.41 | 0.43 | 0.36 |
Median age at first event (years) | 65.29 | 63.15 | 68.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1836
- Matched controls
- 18359
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_CHOROID and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
CD2_BENIGN_CHOROID | 0.835 [0.74, 0.94] | 0.002 |
Birth year | 0.994 [0.98, 1.0] | 0.195 |
During the follow-up period (1.1.1998 — 31.12.2019), 842 out of 5914 females with CD2_BENIGN_CHOROID died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
CD2_BENIGN_CHOROID | 0.838 [0.73, 0.97] | 0.016 |
Birth year | 0.989 [0.98, 1.0] | 0.023 |
During the follow-up period (1.1.1998 — 31.12.2019), 654 out of 3580 males with CD2_BENIGN_CHOROID died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_CHOROID.N-year risk | Females | Males |
---|---|---|
1 | 0.083% | 0.147% |
5 | 0.466% | 1.013% |
10 | 1.192% | 2.645% |
15 | 2.354% | 4.999% |
20 | 4.394% | 8.679% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_CHOROID – Benign neoplasm: Choroid
GWS hits: 1