Benign neoplasm: Choroid

CD2_BENIGN_CHOROID

choroid cancer: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D31.3&
  • Hospital discharge: ICD-9 2246
  • Cause of death: ICD-10 D31.3&
  • Cause of death: ICD-9 2246

2 out of 7 registries used, show all original rules.

2345

4. Check minimum number of events

None

2345

5. Include endpoints

None

2345

6. Filter based on genotype QC (FinnGen only)

2273

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D31
Name in latin
Neoplasma benignum chorioideae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 11875 7347 4502
Only index persons 11506 7160 4346
Unadjusted period prevalence (%)
Whole population 0.18 0.21 0.13
Only index persons 0.23 0.26 0.17
Median age at first event (years)
Whole population 65.87 65.27 66.87
Only index persons 65.71 65.12 66.70

-FinnGen-

Key figures

All Female Male
Number of individuals 2273 1372 901
Unadjusted period prevalence (%) 0.46 0.49 0.41
Median age at first event (years) 65.65 63.64 68.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2345
Matched controls
23450
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
XCD10
NOMESCO Finland
Electrophysiological examination of eye
19.2
307.7
371
227
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
64.0
307.7
252
44
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
15.7
307.7
837
800
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
4503599627370496.0
307.7
2336
30
XCK10
NOMESCO Finland
Photography of fundus of eye
6.8
307.7
693
1358
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.9
294.7
652
1431
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
78.9
170.1
91
12
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.6
168.9
765
2786
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.7
133.7
505
1608
CKE65
NOMESCO Finland
Removal of brachytherapeutic plate from eye
57.9
110.1
62
11
CKE60
NOMESCO Finland
Brachytherapy of choroid and retina
56.9
108.0
61
11
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
24.6
84.5
60
25
XCD20
NOMESCO Finland
Photoangiography of eye
6.9
67.7
106
159
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
51.9
288
1116
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
14.3
49.4
45
32
D31.2
ICD-10 Finland
Benign neoplasm: Retina
106.3
48.0
52
5
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
42.2
1154
8182
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
87.6
38.9
43
5
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
8.0
33.3
45
57
WX140
NOMESCO Finland
Parabulbar anesthesy
2.8
32.8
169
626
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.9
29.6
408
2295
XCH00
NOMESCO Finland
Eye pressure measurement
2.8
28.9
156
592
D31.4
ICD-10 Finland
Benign neoplasm: Ciliary body
76.1
26.8
30
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.1
25.7
282
1459
ZXA10
NOMESCO Finland
Bilateral
1.7
22.7
473
2995
CD2S4
NOMESCO Finland
Photography of eye
7.1
20.8
31
44
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
20.0
812
6022
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
2.5
20.0
126
516
H26.4
ICD-10 Finland
After-cataract
1.8
18.6
277
1584
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.6
18.5
113
456
XCW10
NOMESCO Finland
Assessment of vision
4.1
18.0
49
121
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
67.1
17.7
20
*
OAB50, ,
SPAT
2.2
17.6
147
682
D31.0
ICD-10 Finland
Benign neoplasm: Conjunctiva
5.3
17.0
34
65
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
16.6
683
5038
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
2.1
16.5
163
809
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.9
16.0
228
1284
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
2.2
15.9
134
624
A98
ICPC
Health maint/preventive medicine
2.3
15.7
2248
21294
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
15.5
222
1251
CK2J4
NOMESCO Finland
Infrared imaging of ocular fundus
+∞
14.6
14
*
CKC12
NOMESCO Finland
Photocoagulation of retina
2.3
14.4
106
467
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.7
14.3
318
2032
H53.1
ICD-10 Finland
Subjective visual disturbances
2.0
14.2
162
846
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
2.2
14.0
118
550
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
14.0
270
1660
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
53.7
13.8
16
*
C69.3
ICD-10 Finland
Malignant neoplasm: Choroid
34.2
13.5
17
5
CH2S4
NOMESCO Finland
Photography of iris
40.3
13.2
16
*
ZXA00
NOMESCO Finland
Right side
1.4
13.1
619
4656
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
4.4
12.9
32
74
H40.0
ICD-10 Finland
Glaucoma suspect
1.8
12.7
199
1153
SPAT1262
SPAT
Handing over of treatment supplies
1.5
12.6
405
2814
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
2.4
12.6
82
342
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.4
12.1
560
4184
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
12.0
1061
8845
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
5.1
11.7
24
47
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.0
11.7
51
173
SPAT1153
SPAT
Removal of sutures
1.4
11.6
734
5789
ZXA05
NOMESCO Finland
Left side
1.4
11.5
568
4292
CA1ME
NOMESCO Finland
Ultrasound oculometry
4.7
11.4
26
56
H35.7
ICD-10 Finland
Separation of retinal layers
3.8
11.3
34
91
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
11.1
1525
13535
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.4
10.7
781
6283
H3600, E113,
ICD-10 Finland
3.4
10.6
37
110
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.5
10.5
429
3122
H35.4
ICD-10 Finland
Peripheral retinal degeneration
4.4
10.3
25
57
J01DB01
ATC
cefalexin; oral
1.4
10.1
1820
16709
8720/3-C69.9
ICD-O-3
Malignant melanoma, NOS, of eye, NOS
40.2
10.0
12
*
8720/3-C69.3
ICD-O-3
Malignant melanoma, NOS, of choroid
26.1
9.8
13
5
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.3
9.7
75
338
SPAT1263
SPAT
Sampling
1.3
9.7
888
7364
H31.8
ICD-10 Finland
Other specified disorders of choroid
55.2
9.6
11
*
R44
ICPC
Respiratory, Preventive immunization/medic
2.8
9.6
47
171
E0000UV, ,
ATC
1.3
9.5
865
7168
XCK00
NOMESCO Finland
Perimetry
1.8
9.4
142
813
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.1
9.4
84
403
H25.0
ICD-10 Finland
Senile incipient cataract
1.7
9.2
159
948
C69.39
ICD-10 Finland
Malignant tumor in chorioidea other or unspecified histology
36.8
9.0
11
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
3.7
8.9
27
73
R01AD09
ATC
mometasone; nasal
1.3
8.9
911
7655
Z2221
NOMESCO Finland
Medical doctor
1.4
8.8
562
4403
N02BE01
ATC
paracetamol; systemic, rectal
1.5
8.8
2030
19118
T90
ICPC
Diabetes non-insulin dependent
1.4
8.7
535
4168
WX002
NOMESCO Finland
Sedation and analgesia
1.4
8.7
434
3269
A02BC05
ATC
esomeprazole; systemic
1.3
8.5
871
7308
SFA20
NOMESCO Finland
Two-surface restoration
1.3
8.4
1179
10302
T89
ICPC
Diabetes insulin dependent
2.1
8.3
76
368
G04CB01
ATC
finasteride; oral
1.6
8.3
216
1429
CF2S4
NOMESCO Finland
Photography of conjunctiva
10.8
8.3
15
14
SPAT1301
SPAT
No procedures
1.3
8.2
663
5373
WX142
NOMESCO Finland
Sub-tenon anesthesy
3.9
8.1
23
59
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.0
8.1
88
454
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
1.6
8.0
194
1264
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
4.6
7.9
18
39
H3601, E103,
ICD-10 Finland
4.6
7.9
18
39
103
Kela drug reimbursment
Diabetes, insulin-treated
1.3
7.8
574
4583
WX720
NOMESCO Finland
Own respiration
1.8
7.8
104
574
SPAT1325
SPAT
Vaccination
1.3
7.8
727
6002
D31.1
ICD-10 Finland
Benign neoplasm: Cornea
45.1
7.7
9
*
L17
ICPC
Foot/toe symptom/complaint
1.3
7.7
611
4933
F29
ICPC
Eye symptom/complaint other
1.6
7.7
194
1274
L15
ICPC
Knee symptom/complaint
1.3
7.7
509
4002
SDA03
NOMESCO Finland
Periodontal treatment
1.3
7.7
772
6437
SPAT1310
SPAT
Counselling related to known health issue
1.3
7.4
662
5427
1906B
ICD-9 Finland
Malignant neoplasm of eye, Choroid[MELANOMA CHORIOIDEAE]
+∞
7.3
7
*
Z010, D313,
ICD-10 Finland
+∞
7.3
7
*
C10AA05
ATC
atorvastatin; oral
1.3
7.3
941
8086
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
7.3
532
4243
H35.37
ICD-10 Finland
Macular holes
2.5
7.1
41
163
G04BD12
ATC
mirabegron; oral
1.5
7.1
268
1916
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
3.8
7.1
21
56
R42
ICD-10 Finland
Dizziness and giddiness
1.3
7.0
481
3795
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.4
7.0
271
1946
H35.9
ICD-10 Finland
Retinal disorder, unspecified
4.4
7.0
17
39
S18
ICPC
Laceration/cut
1.3
6.9
991
8605
UDC00
NOMESCO Finland
Ear microscopy
1.6
6.9
150
952
D31.9
ICD-10 Finland
Benign neoplasm: Eye, unspecified
13.8
6.9
11
8
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
6.9
836
7118
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
6.8
877
7518
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
6.8
565
4582
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
1.9
6.7
82
441
D18.0
ICD-10 Finland
Haemangioma, any site
2.2
6.7
54
249
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.3
6.7
576
4687
F01
ICPC
Eye pain
2.1
6.7
57
269
WX704
NOMESCO Finland
Intubation
1.6
6.7
162
1055
C10AA01
ATC
simvastatin; oral
1.3
6.6
948
8217
H36.00
ICD-10 Finland
Diabetic background retinopathy
2.8
6.6
31
111
SPAT1260
SPAT
Consultation of another employee
1.4
6.6
359
2735
JAETT, ,
NOMESCO Finland
3.8
6.5
19
50
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
6.5
364
2787
C69.02
ICD-10 Finland
Malignant tumor in conjunctival melanoma
70.0
6.4
7
*
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
6.4
756
6404
H25.8
ICD-10 Finland
Other senile cataract
1.4
6.3
244
1751
2246A
ICD-9 Finland
Benign neoplasm of eye, Choroid
+∞
6.3
6
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.2
618
5118
SPAT1312
SPAT
General health counselling
1.3
6.2
625
5184
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
6.2
462
3684
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.2
6.2
1110
9845
M01AH05
ATC
etoricoxib; oral
1.2
6.2
1282
11551
R74
ICPC
Upper respiratory infection acute
1.3
6.2
528
4292
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
6.1
582
4792
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.3
6.1
507
4103
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
6.1
729
6175
F05
ICPC
Visual disturbance other
2.0
6.1
66
342
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.6
6.1
128
807
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
6.1
1318
11925
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.3
6.0
511
4146
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.4
6.0
282
2094

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
2052
18494
1.88
22.30
6.9
6.1
40.76
40.20
mmol/mol
1.88
1871
16998
2205
20556
2.22
19.03
19.3
17.7
139.78
139.67
mmol/l
1.31
2159
20038
2208
20602
2.23
18.90
19.4
17.9
3.97
3.98
mmol/l
0.19
2159
20057
844
6371
1.51
18.85
3.7
3.2
566.43
350.43
mg/l
0.49
528
4014
2232
20930
2.38
18.66
12.7
11.0
25.04
25.26
u/l
0.30
2145
20165
2281
21609
3.04
18.65
24.8
22.6
40.16
39.77
%
2.27
2059
20111
2281
21624
3.01
18.33
25.0
22.5
248.26
249.79
e9/l
0.55
2231
21054
2281
21629
3.00
18.23
24.9
22.5
6.66
6.74
e9/l
0.65
2224
20992
2281
21629
3.00
18.23
24.8
22.5
91.19
91.35
fl
0.98
2249
21293
866
6606
1.49
18.22
3.6
3.1
7.08
7.20
mmol/l
0.33
701
5539
2281
21632
3.00
18.16
24.9
22.5
4.46
4.44
e12/l
0.74
2221
20993
2281
21636
2.99
18.08
25.0
22.7
134.73
134.04
g/l
1.61
2250
21303
2280
21631
2.95
17.88
24.8
22.4
30.34
30.35
pg
0.12
2249
21292
873
6707
1.48
17.56
4.3
3.8
10.36
8.33
mg/mmol
0.47
531
4172
2177
20304
2.01
17.08
16.8
14.5
—
—
—
0
0
2223
20911
2.21
16.73
19.8
17.9
79.07
77.89
umol/l
0.76
2223
20903
2097
19381
1.78
16.17
5.3
4.8
6.01
5.99
mmol/l
0.27
1885
17533
2139
19932
1.83
15.39
5.8
5.2
2.65
2.72
mmol/l
3.06
1933
18225
1254
10580
1.40
13.94
7.1
6.7
1.22
1.22
mmol/l
0.78
1027
8978
1177
9845
1.39
13.66
15.5
16.2
1.25
1.28
inr
0.56
358
2817
1989
18312
1.57
13.40
5.5
4.9
4.36
2.02
mu/l
0.75
1792
16646
2106
19688
1.68
12.97
16.4
15.2
21.53
24.43
mg/l
4.17
1673
15722
2092
19524
1.66
12.97
5.1
4.6
4.57
4.64
mmol/l
2.14
1907
17958
1150
9643
1.38
12.83
6.5
5.9
1.22
1.21
mmol/l
1.66
1038
8772
2077
19370
1.63
12.65
5.0
4.6
1.48
1.48
mmol/l
0.28
1880
17695
1344
11700
1.35
11.07
9.4
9.0
4.01
4.12
e9/l
1.13
1199
10188
1741
15788
1.40
11.04
8.8
7.6
76.80
78.86
u/l
1.27
1632
14868
1694
15293
1.39
11.03
4.4
4.1
14.92
14.90
pmol/l
0.11
1513
13808
700
5525
1.38
10.87
1.8
1.7
1.34
1.37
mmol/l
0.34
588
4604
1510
13431
1.35
10.49
5.0
4.7
38.69
1847.99
e6/l
2.87
13
206
1601
14386
1.36
10.28
4.4
4.0
—
—
—
0
0
1550
13865
1.35
10.22
5.1
4.5
—
—
—
0
0
989
8296
1.33
10.14
2.4
2.1
—
—
—
0
0
539
4119
1.40
10.03
1.3
1.2
0.92
1.31
u/ml
1.07
131
1060
1035
8763
1.32
9.85
2.1
2.0
98.08
94.61
pmol/l
1.21
489
4434
1651
15014
1.34
9.08
4.6
4.2
12.22
13.03
mm/h
1.46
1518
13855
1995
18720
1.44
8.87
4.5
4.1
1.28
1.29
mmol/l
0.37
1799
16957
1089
9400
1.30
8.57
6.9
6.2
—
—
—
0
0
767
6327
1.32
8.43
4.6
4.0
7.40
7.40
ph
0.20
153
1224
1817
16838
1.35
8.28
19.3
18.1
17.42
15.15
%
0.51
1786
16531
996
8536
1.29
8.14
2.5
2.2
80.21
78.86
nmol/l
0.69
868
7584
120
684
1.80
8.14
5.0
6.6
1.32
1.31
mmol/l
0.00
103
596
1180
10367
1.28
7.80
6.2
5.9
0.19
0.19
e9/l
0.01
1061
9031
1345
12053
1.27
7.38
5.2
4.8
6.80
6.77
mmol/l
0.15
1281
11335
303
2204
1.43
7.31
1.8
2.2
120.97
140.17
ug/g
0.35
235
1746
90
488
1.88
7.20
5.3
7.6
105.13
105.19
mmol/l
0.04
80
434
90
488
1.88
7.20
5.3
7.6
11.24
11.22
mmol/l
0.02
80
434
1218
10807
1.26
7.17
7.0
6.3
11.06
11.43
umol/l
0.77
1158
10268
65
327
2.02
6.49
1.3
1.4
—
—
—
0
0
1069
9432
1.25
6.29
6.7
6.2
8.56
8.69
%
0.71
1008
8804
1126
10001
1.24
6.20
6.2
5.7
0.58
0.59
e9/l
0.65
1008
8593
1064
9393
1.24
6.19
6.4
5.9
2.84
2.83
%
0.03
1002
8755
211
1479
1.47
6.19
1.2
1.2
—
—
—
0
0
1073
9493
1.24
6.09
6.2
5.8
57.26
57.48
%
0.25
1010
8872
74
399
1.88
6.07
1.9
1.9
5.42
5.02
mmol/24h
0.42
61
341
1126
10024
1.24
6.00
6.2
5.7
0.04
0.04
e9/l
0.41
1007
8613
1033
9116
1.24
5.95
6.4
5.9
0.69
0.67
%
0.44
970
8487
455
3643
1.31
5.92
1.5
1.4
2.31
2.50
g/l
1.34
256
2174
721
6124
1.26
5.84
5.8
5.2
2.51
2.93
ug/l
0.62
632
5469
1085
9639
1.23
5.83
6.5
6.0
28.08
27.44
%
1.09
1024
9016
1025
9059
1.23
5.76
5.4
4.8
35.48
35.23
g/l
0.75
944
8442
1144
10254
1.23
5.54
6.3
5.7
1.93
1.92
e9/l
0.05
1040
9014
257
1910
1.39
5.47
4.0
2.9
193.11
200.59
ng/l
0.09
231
1741
232
1698
1.41
5.40
3.5
3.7
92.03
90.41
ng/l
0.08
193
1464
905
7941
1.23
5.33
4.1
3.8
27.82
111.82
ng/l
0.88
622
5722
728
6269
1.23
5.07
4.3
4.0
—
—
—
0
0
1091
9791
1.21
5.04
5.2
5.1
0.00
0.00
estimate
0.50
222
1843
1090
9788
1.21
4.99
4.1
3.9
0.00
0.00
estimate
0.99
229
1972
1363
12511
1.21
4.96
3.5
3.2
46.85
50.73
u/l
0.65
1255
11564
739
6390
1.23
4.92
2.0
2.2
165.64
216.75
u/l
1.29
687
5975
188
1351
1.43
4.87
8.4
7.0
24.50
24.51
mmol/l
0.02
179
1281
50
259
1.95
4.69
1.1
1.1
0.17
2.38
u/ml
2.71
28
131
330
2611
1.31
4.64
1.3
1.3
619.02
546.92
titre
0.21
61
584
740
6433
1.22
4.62
2.9
2.5
57.72
71.80
u/l
0.57
679
5932
1097
9916
1.20
4.52
4.1
3.9
0.00
0.01
estimate
1.08
216
1789
44
225
1.97
4.31
1.1
1.0
5.60
4.21
u/ml
0.20
26
105
224
1705
1.35
4.13
4.5
4.1
—
—
—
0
0
484
4087
1.23
3.94
4.3
3.8
429.53
360.00
ng/l
0.13
378
3293
729
6411
1.20
3.92
3.8
3.2
30.34
34.49
u/l
1.69
700
6091
159
1163
1.39
3.78
7.0
10.0
—
—
—
0
0
198
1501
1.35
3.77
2.7
2.8
10.45
10.59
g/l
0.14
181
1361
288
2302
1.29
3.75
1.3
1.3
—
—
—
0
0
515
4398
1.22
3.74
2.0
1.8
0.97
1.25
mg/l
2.72
399
3394
871
7814
1.18
3.68
3.7
3.5
5.88
5.82
ph
0.24
73
474
155
1134
1.39
3.68
2.4
2.4
—
—
—
0
0
613
5335
1.20
3.65
4.8
4.2
0.00
0.00
estimate
1.08
214
1783
22
91
2.43
3.64
2.1
2.6
1959.59
1104.96
u/ml
0.36
22
91
38
197
1.94
3.63
1.1
1.0
1.41
1.40
u/ml
0.00
22
97
41
220
1.88
3.55
1.1
1.1
0.76
1.51
u/ml
0.49
21
89
327
2674
1.26
3.54
1.4
1.3
—
—
—
0
0
32
158
2.04
3.50
1.1
1.2
—
—
—
0
0
595
5184
1.20
3.48
3.4
3.5
—
—
—
0
0
160
1190
1.37
3.46
1.9
1.8
1.25
1.49
g/l
0.53
143
1080
322
2637
1.26
3.44
5.1
4.7
33.29
32.93
%
0.24
218
1753
159
1190
1.36
3.31
3.8
3.3
4.33
4.44
pmol/l
0.79
139
1044
126
909
1.41
3.28
1.3
1.2
—
—
—
0
0
917
8337
1.16
3.17
2.9
2.8
123.11
134.64
ug/l
0.92
838
7653
192
1491
1.31
3.13
1.5
1.4
—
—
—
0
0
471
4059
1.20
3.08
1.8
1.8
1235.16
1186.54
nmol/l
0.53
349
3046
64
408
1.58
3.06
1.8
1.4
—
—
—
0
0
712
6394
1.16
2.82
3.2
3.0
1650.29
1389.45
ng/l
0.42
602
5490
8
18
4.46
2.79
4.5
2.9
—
—
—
0
0
735
6641
1.16
2.66
3.1
3.2
—
—
—
0
0
32
176
1.83
2.64
3.9
5.1
55.75
42.09
u/ml
—
10
50
795
7229
1.15
2.63
3.7
3.4
2.36
2.36
mmol/l
0.01
672
6332
84
592
1.43
2.55
1.4
1.3
28.94
33.99
iu/l
0.80
77
505
331
2809
1.21
2.55
6.2
5.5
1.05
1.03
mmol/l
0.51
295
2597
117
874
1.36
2.53
4.5
5.5
0.93
0.89
%
0.78
107
815
14
56
2.51
2.53
1.6
1.5
—
—
—
0
0
181
1440
1.28
2.51
5.8
4.9
—
—
—
0
0
570
5075
1.16
2.50
1.5
1.6
21.91
20.82
nmol/l
0.69
480
4291
29
158
1.85
2.48
1.0
1.1
0.41
3.99
u/ml
2.11
14
61
230
1886
1.24
2.47
1.4
1.4
—
—
—
0
0
18
82
2.20
2.47
1.1
1.1
5060.71
441.28
ng/l
—
7
21
117
881
1.35
2.42
4.5
5.5
1.70
1.58
%
0.71
107
822
378
3275
1.18
2.32
1.3
1.3
11.95
12.42
u/ml
0.04
130
1218
512
4548
1.16
2.30
1.7
1.7
42752269.25
24866742.92
pmol/l
0.24
407
3740
339
2913
1.19
2.29
1.2
1.2
—
—
—
0
0
13
53
2.46
2.27
2.3
2.2
33.15
27.04
%
0.56
13
46
13
53
2.46
2.27
2.4
2.2
8.46
12.18
%
0.52
13
45
27
468
0.57
2.24
3.4
3.0
1.32
1.56
mmol/l
2.08
27
455
66
457
1.46
2.24
1.5
1.2
3.92
3.83
mmol/l
0.18
59
428
25
441
0.56
2.21
3.6
3.1
7.59
7.51
mmol/l
0.06
25
430
1028
9596
1.13
2.18
2.6
2.6
—
—
—
0
0
72
510
1.42
2.17
1.1
1.1
4.17
5.73
u/ml
—
7
52
259
2186
1.21
2.13
4.8
4.3
—
—
—
0
0
30
174
1.73
2.13
1.2
1.5
0.33
0.39
g/l
0.53
19
120
30
174
1.73
2.13
1.2
1.5
2.84
2.93
g/l
0.09
19
120
30
174
1.73
2.13
1.2
1.5
5.95
7.00
g/l
0.96
19
120
388
3395
1.17
2.12
1.3
1.3
31.56
37.52
iu/ml
0.50
126
1107
23
123
1.88
2.11
5.0
6.6
—
—
—
0
0
65
457
1.43
2.06
4.0
3.9
—
—
—
0
0
31
184
1.69
2.04
1.1
1.1
—
—
—
0
0
277
2364
1.19
2.03
1.7
1.8
—
—
—
0
0
73
529
1.39
1.97
2.5
2.0
11.85
12.10
mg/l
0.10
65
487
216
1807
1.22
1.96
3.0
2.8
66.31
66.38
g/l
0.05
192
1649
85
633
1.36
1.94
1.4
1.4
298.04
279.90
ug/g
0.35
48
376
95
720
1.33
1.94
1.2
1.2
2.23
0.87
u/ml
0.31
13
61
10
39
2.57
1.94
1.3
1.1
—
—
—
0
0
212
1776
1.21
1.90
4.6
3.7
1.23
1.23
mmol/l
0.26
178
1549
268
2296
1.19
1.89
4.6
4.1
17.29
21.18
ug/l
0.18
225
1879
145
1169
1.26
1.87
1.2
1.3
154.23
199.16
u/ml
0.42
130
1075
183
1514
1.23
1.86
2.2
2.5
—
—
—
0
0
119
937
1.28
1.86
1.9
1.9
—
—
—
0
0
23
129
1.79
1.85
1.3
1.5
0.86
0.97
g/l
1.13
23
129
23
129
1.79
1.85
2.1
2.1
14.26
16.04
%
0.39
23
122
35
221
1.59
1.85
3.0
4.3
—
—
—
0
0
285
2467
1.18
1.79
6.6
7.2
1.18
1.18
mmol/l
0.00
221
1940
31
192
1.62
1.78
3.0
3.1
109.19
29.74
mg/l
0.45
24
145
240
2050
1.19
1.77
7.3
7.9
118.35
120.73
g/l
1.07
231
1991
386
3425
1.15
1.77
4.1
3.2
0.83
0.82
mmol/l
1.05
350
3211
73
541
1.36
1.75
1.2
1.2
410.00
1227.50
titre
—
5
20
480
4326
1.14
1.75
4.5
4.3
1.02
1.02
kg/l
0.41
67
642
284
2465
1.17
1.74
6.6
7.2
11.92
12.24
kpa
0.48
272
2352
284
2465
1.17
1.74
6.6
7.2
5.03
5.10
kpa
0.60
271
2353
52
364
1.44
1.73
1.6
1.3
10.61
11.98
u/l
0.29
43
291
29
178
1.64
1.73
1.2
1.5
—
—
—
0
0
19
103
1.85
1.71
1.5
1.5
—
—
—
0
0
23
133
1.74
1.70
2.1
2.1
75.39
71.00
%
0.89
23
122
625
5742
1.12
1.66
4.4
4.3
—
—
—
0
0
10
40
2.51
1.66
1.2
1.5
—
—
—
0
0
71
529
1.35
1.66
3.1
3.1
1.67
1.59
mg/l
0.33
63
486
43
293
1.48
1.65
1.3
1.7
1.29
0.85
g/l
0.30
30
221
73
547
1.35
1.65
1.6
1.6
0.22
0.24
g/l
1.28
68
519
586
5367
1.12
1.64
2.9
2.7
2251.68
5653.37
umol/l
2.07
495
4665
50
352
1.43
1.63
1.7
1.5
—
—
—
0
0
145
1191
1.23
1.61
2.4
2.1
13.03
12.57
nmol/l
0.26
127
1046
164
1371
1.21
1.55
2.6
3.1
3.91
5.20
e9/l
1.66
129
1091
56
407
1.39
1.54
4.2
3.3
55.21
57.52
%
0.79
56
407
37
249
1.49
1.52
1.6
1.5
49.30
61.23
%
0.96
23
158
237
2052
1.17
1.52
1.5
1.6
—
—
—
0
0
261
2278
1.16
1.51
3.4
2.6
9.13
8.20
umol/l
0.20
229
1990
214
1839
1.18
1.50
2.2
2.7
70.47
70.42
e9/l
0.00
166
1412
18
101
1.79
1.49
1.3
1.4
1.58
1.57
g/l
0.05
18
101
13
65
2.01
1.48
1.3
1.5
—
—
—
0
0
38
546
0.69
1.47
3.8
4.5
—
—
—
0
0
43
301
1.44
1.47
4.8
2.7
—
—
—
0
0
34
227
1.51
1.46
4.2
6.5
6.85
7.39
mmol/l
0.54
26
190
60
446
1.35
1.46
1.6
1.4
8.02
31.74
e6/l
1.02
48
348
60
446
1.35
1.46
1.7
1.5
323.71
963.30
e6/l
0.98
49
367
29
187
1.56
1.45
1.4
1.8
—
—
—
0
0
365
3273
1.14
1.45
2.5
2.5
12.68
12.84
umol/l
0.17
332
3059
103
827
1.26
1.43
4.0
3.9
24.76
24.87
mmol/l
0.16
85
770
253
2214
1.16
1.42
7.0
7.6
95.49
95.52
%
0.02
242
2132
36
245
1.48
1.42
1.8
1.5
—
—
—
0
0
511
4686
1.12
1.40
4.2
3.8
—
—
—
0
0
598
5531
1.11
1.40
3.4
3.1
—
—
—
0
0
53
390
1.37
1.38
3.8
3.0
3.61
4.25
e9/l
1.70
53
390
181
1546
1.19
1.38
4.4
4.2
0.30
0.46
%
0.18
56
437
36
247
1.46
1.38
2.8
2.7
—
—
—
0
0
75
582
1.30
1.37
1.0
1.1
—
—
—
0
0
200
1724
1.18
1.37
4.3
4.1
1.14
0.92
%
0.48
76
611
5
17
2.94
1.36
1.4
1.6
—
—
—
0
0
214
1857
1.17
1.35
2.5
2.2
343.04
370.75
nmol/l
1.51
191
1692
157
1328
1.20
1.34
3.7
3.6
7.40
7.41
ph
0.23
25
172
14
75
1.87
1.34
3.4
2.0
1159.51
129.17
ug/l
0.41
14
63
47
341
1.39
1.34
2.0
2.6
—
—
—
0
0
147
1237
1.20
1.33
1.2
1.2
78.51
151.64
iu/ml
3.15
57
456
32
464
0.69
1.33
3.1
3.8
31.33
27.69
mg/l
0.14
22
291
480
4400
1.11
1.32
2.9
2.6
5.50
5.67
e6/l
0.04
435
3960
1658
16112
1.10
1.31
21.4
19.9
332.52
331.75
g/l
3.17
1648
15986
6
24
2.50
1.30
1.0
1.1
—
—
—
0
0
14
76
1.85
1.29
2.6
2.5
—
—
—
0
0
158
1344
1.19
1.28
3.7
3.6
5.12
5.16
kpa
0.22
141
1285
557
5157
1.11
1.27
6.7
6.6
—
—
—
0
0
21
130
1.62
1.26
2.0
1.6
—
—
—
0
0
269
2388
1.14
1.26
1.5
1.4
—
—
—
0
0
26
170
1.54
1.26
1.0
1.0
0.23
2.44
u/ml
4.05
11
79
18
107
1.69
1.25
3.1
2.9
—
—
—
0
0
182
1574
1.17
1.22
4.1
3.9
0.73
0.67
%
0.16
66
529
389
3544
1.12
1.21
3.6
3.1
0.72
0.76
ug/l
0.55
266
2444
30
206
1.46
1.17
3.1
3.3
64.24
56.43
%
1.16
25
175
59
456
1.30
1.15
2.6
2.5
15.31
16.19
%
0.84
33
228
98
806
1.23
1.15
1.6
2.6
9.30
10.30
g/l
1.54
85
725
8
40
2.00
1.12
11.3
7.0
—
—
—
0
0
61
476
1.29
1.12
4.3
4.7
2.57
2.61
mmol/l
0.04
45
336
22
143
1.54
1.11
1.0
1.0
0.04
0.35
u/ml
—
5
50
208
1833
1.15
1.11
1.5
1.5
—
—
—
0
0
44
329
1.34
1.09
2.2
2.0
3356.72
2060.59
u/l
0.21
15
129
39
286
1.37
1.09
1.8
1.8
198.62
201.77
pmol/l
0.06
39
270
65
515
1.27
1.07
1.3
1.3
—
—
—
0
0
45
339
1.33
1.06
3.0
3.5
1.30
1.37
%
0.06
40
301
38
279
1.37
1.06
1.0
1.1
1.47
1.53
g/l
0.38
30
251
762
7215
1.08
1.05
4.1
3.7
87.63
111.46
e6/l
0.48
551
5159
14
82
1.71
1.05
10.8
7.5
244.37
66.82
mg/l
—
8
60
49
375
1.31
1.05
1.5
1.5
—
—
—
0
0
65
517
1.26
1.04
2.5
2.3
225.93
114.29
ug/min
0.36
35
316
610
5725
1.09
1.04
3.5
3.1
0.35
0.48
e6/l
0.81
466
4393
99
825
1.21
1.04
3.0
2.5
—
—
—
0
0
67
535
1.26
1.04
1.2
1.2
56.00
83.85
titre
—
5
39
186
1635
1.15
1.04
4.5
4.2
0.08
0.12
%
0.52
63
525
42
315
1.34
1.03
1.9
2.2
—
—
—
0
0
90
1082
0.83
1.02
3.2
3.5
—
—
—
0
0
20
131
1.53
0.99
2.1
2.1
515.80
490.80
min
—
10
95
39
291
1.35
0.99
1.3
1.3
0.59
0.65
nmol/l
0.49
39
278
323
2949
1.11
0.99
2.0
2.1
—
—
—
0
0
171
1942
0.87
0.98
3.5
3.5
2.05
2.00
mmol/l
0.07
154
1622
80
968
0.82
0.98
3.2
2.6
0.63
0.64
%
0.09
80
961
5
23
2.18
0.98
1.0
1.3
—
—
—
0
0
5
23
2.18
0.98
1.0
1.3
—
—
—
0
0
5
23
2.18
0.98
1.0
1.3
—
—
—
0
0
25
173
1.45
0.97
1.2
1.2
—
—
—
0
0
117
998
1.18
0.97
1.5
1.6
—
—
—
0
0
142
1235
1.16
0.94
1.3
1.3
124.52
59.80
au/ml
—
5
70
37
277
1.34
0.93
1.5
1.4
23.01
50.89
mu/l
1.62
32
248
8
143
0.56
0.93
1.5
1.1
—
—
—
0
0
9
52
1.73
0.92
1.4
2.2
—
—
—
0
0
554
5208
1.08
0.91
3.7
3.9
89.22
89.50
%
0.09
531
5080
34
253
1.35
0.90
1.4
1.2
—
—
nmol/l
—
0
0
123
1062
1.17
0.90
1.4
1.2
—
—
—
0
0
17
254
0.67
0.89
3.4
2.5
—
—
—
0
0
19
127
1.50
0.88
1.3
1.0
—
—
—
0
0
348
3211
1.10
0.88
2.0
2.1
29.53
29.85
s
0.47
336
3105
82
686
1.20
0.86
3.7
3.5
3.47
1.73
ratio
—
8
57
65
531
1.23
0.86
4.3
3.6
—
—
—
0
0
11
64
1.72
0.86
1.4
1.4
1.89
2.07
umol/l
0.34
11
59
59
478
1.24
0.85
1.9
1.9
3.15
4.71
iu/l
0.89
23
158
6
31
1.94
0.84
2.7
2.2
17.17
19.04
umol/l
—
6
31
33
248
1.34
0.83
1.3
1.2
—
—
—
0
0
10
57
1.76
0.83
1.5
1.1
303.40
296.50
pmol/l
—
5
40
45
354
1.28
0.83
2.0
1.9
2.02
1.72
mmol/l
0.91
45
347
84
992
0.84
0.83
3.1
2.6
1.27
1.17
%
0.45
84
983
21
146
1.44
0.82
1.3
1.3
—
—
—
0
0
31
232
1.34
0.81
1.0
1.1
—
—
—
0
0
51
410
1.25
0.80
1.2
1.5
0.76
0.82
nmol/l
0.19
35
336
12
74
1.62
0.78
1.3
1.3
—
—
—
0
0
31
234
1.33
0.77
1.0
1.1
—
—
—
0
0
308
2846
1.09
0.77
2.5
2.5
22.76
22.53
%
0.10
239
2432
34
261
1.31
0.76
1.6
1.4
261.43
323.97
pmol/l
1.00
28
226
68
570
1.20
0.73
4.3
4.4
7.42
7.42
ph
0.19
63
515
8
135
0.59
0.73
5.5
3.4
—
—
—
0
0
675
6446
1.07
0.72
3.0
3.0
—
—
—
0
0
12
76
1.58
0.71
1.3
1.1
—
—
—
0
0
325
3024
1.09
0.71
2.6
2.5
2.28
2.31
g/l
0.40
293
2807
5
26
1.93
0.70
1.0
1.1
—
—
—
0
0
15
101
1.49
0.70
11.6
12.8
—
—
—
0
0
30
230
1.31
0.69
2.7
2.1
—
—
—
0
0
10
157
0.64
0.69
1.5
1.5
—
—
—
0
0
5
27
1.85
0.68
1.0
1.2
1.51
1.84
umol/24h
—
5
27
25
187
1.34
0.68
1.0
1.0
—
—
—
0
0
19
136
1.40
0.66
1.2
1.2
—
—
—
0
0
5
28
1.79
0.66
1.4
1.2
—
—
—
0
0
13
86
1.51
0.66
1.2
1.2
—
—
—
0
0
650
6221
1.06
0.65
3.6
3.3
173.16
82.49
e6/l
0.56
504
4814
82
708
1.16
0.65
3.8
3.5
52.99
63.64
mg/l
0.32
63
584
17
120
1.42
0.64
1.5
3.0
7.41
7.42
ph
—
6
40
26
198
1.32
0.64
1.8
1.5
—
—
—
0
0
82
710
1.16
0.63
3.8
3.5
35.94
77.51
mg/l
1.25
64
587
35
436
0.80
0.63
1.3
1.3
117.18
218.27
miu/ml
1.03
11
190
34
270
1.26
0.62
2.6
2.2
550.77
1117.60
u/ml
0.22
34
264
17
234
0.72
0.62
1.1
1.2
—
—
—
0
0
110
975
1.13
0.62
3.8
3.7
—
—
—
0
0
193
1767
1.10
0.62
4.3
3.4
—
—
—
0
0
5
30
1.67
0.61
7.2
7.7
—
—
—
0
0
10
152
0.66
0.61
1.4
1.4
—
—
—
0
0
34
271
1.26
0.61
1.3
1.3
—
—
—
0
0
0
20
0.00
0.60
0.0
1.7
—
0.07
—
0
13
56
472
1.19
0.60
2.3
2.2
122.34
129.46
g/l
1.50
44
348
20
148
1.35
0.59
2.6
1.6
—
—
—
0
0
10
151
0.66
0.59
1.4
1.4
—
—
—
0
0
142
1284
1.11
0.58
1.4
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
717.88
—
0
8
23
298
0.77
0.57
1.3
1.7
—
—
—
0
0
159
1739
0.91
0.55
6.7
8.0
—
—
—
0
0
45
375
1.20
0.55
1.7
1.6
—
—
—
0
0
13
90
1.45
0.55
1.2
1.3
127.69
163.87
mmol/24h
0.91
13
90
203
1876
1.09
0.55
9.6
7.1
10.64
9.99
mmol/l
0.63
191
1788
47
394
1.20
0.55
2.9
2.8
—
—
—
0
0
219
2036
1.08
0.52
2.4
2.2
0.21
0.21
g/l
0.08
204
1906
28
224
1.25
0.51
5.3
2.3
1.24
1.46
g/24h
0.17
14
107
9
65
1.39
0.50
1.0
1.1
1328.00
1680.91
miu/ml
—
9
65
124
1364
0.90
0.50
9.4
8.6
1.26
1.33
%
0.46
124
1355
6
41
1.46
0.50
1.2
1.3
—
—
—
0
0
16
119
1.35
0.48
2.9
2.8
37.75
40.17
%
—
8
68
124
1359
0.91
0.47
9.3
8.7
0.67
0.67
%
0.00
124
1350
19
146
1.30
0.47
1.2
1.2
0.70
1.31
u/ml
0.38
14
78
58
504
1.15
0.47
1.7
1.6
8265.72
13871.97
e6/l
1.09
39
369
173
1865
0.92
0.46
2.5
2.4
6.49
6.71
ug/l
0.07
140
1653
55
477
1.16
0.46
2.0
1.6
—
—
—
0
0
202
1885
1.08
0.46
2.5
2.3
35.06
40.13
u/l
0.73
177
1625
7
51
1.37
0.44
1.1
1.1
—
—
—
0
0
76
678
1.12
0.43
1.4
2.4
38.56
37.69
g/l
0.53
63
599
22
175
1.26
0.43
2.0
2.3
816.83
629.22
ml
0.90
12
117
97
878
1.11
0.43
1.8
2.0
4.13
2.09
ug/l
0.54
78
778
5
31
1.61
0.43
3.4
1.4
154.20
86.72
ng/l
—
5
31
148
1370
1.09
0.42
2.6
2.4
23.96
25.18
au/ml
0.04
16
88
20
158
1.27
0.41
1.2
1.2
—
—
—
0
0
8
58
1.38
0.41
1.0
1.2
—
—
—
0
0
18
228
0.79
0.41
3.7
3.1
—
—
—
0
0
64
567
1.13
0.41
2.4
2.6
—
—
—
0
0
137
1266
1.09
0.41
1.4
1.3
—
—
—
0
0
198
1857
1.07
0.41
1.6
1.5
—
—
—
0
0
5
34
1.47
0.40
2.8
3.4
50.60
43.48
umol/l
—
5
26
8
60
1.33
0.40
1.6
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
9.3
—
—
—
0
0
8
61
1.31
0.39
1.8
1.6
71.38
83.98
nmol/24h
—
8
61
258
2447
1.06
0.38
2.1
2.6
1.85
1.83
%
0.07
223
2173
34
289
1.18
0.38
1.2
1.1
—
—
—
0
0
77
697
1.11
0.36
1.6
1.6
—
—
—
0
0
11
82
1.34
0.34
1.0
1.0
—
8.97
—
0
9
20
163
1.23
0.34
1.3
1.2
384.75
377.80
nmol/l
0.07
20
142
6
45
1.33
0.33
1.8
1.4
—
—
—
0
0
43
488
0.88
0.33
1.0
1.2
—
—
—
0
0
50
444
1.13
0.33
1.7
1.6
257.07
308.21
mu/l
0.90
42
407
6
88
0.68
0.33
1.2
1.2
—
—
—
0
0
53
473
1.12
0.33
3.1
3.3
0.93
0.83
nmol/l
0.61
38
369
34
294
1.16
0.32
1.6
1.4
126.08
126.22
u/ml
0.00
12
56
28
238
1.18
0.32
1.7
1.1
—
—
—
0
0
549
5333
1.04
0.32
2.4
2.2
2.61
3.03
mg/l
5.69
461
4542
24
201
1.20
0.32
1.5
1.3
9316.33
107890.27
e6/l
1.21
15
135
18
146
1.23
0.32
1.6
2.1
8.64
6.98
mmol/l
0.49
12
91
92
996
0.92
0.31
1.5
1.8
1.59
1.54
g/l
0.21
73
862
144
1353
1.07
0.31
1.2
1.3
—
—
—
0
0
7
54
1.30
0.30
1.0
1.0
—
—
—
0
0
28
240
1.17
0.30
1.5
2.4
—
—
—
0
0
491
5055
0.96
0.30
2.5
2.4
—
—
—
0
0
7
55
1.27
0.30
1.1
1.0
—
—
—
0
0
20
166
1.21
0.29
2.3
2.4
—
—
—
0
0
7
56
1.25
0.29
1.4
1.7
16.23
14.50
pmol/l
—
7
45
673
6576
1.03
0.29
2.5
2.4
—
—
—
0
0
8
63
1.27
0.27
1.1
1.9
2.15
1.28
ug/l
—
8
57
13
104
1.25
0.26
1.5
1.3
138.85
140.01
nmol/l
0.03
13
104
10
77
1.30
0.26
2.5
2.4
—
—
—
0
0
17
202
0.84
0.24
1.3
2.2
—
—
—
0
0
22
189
1.17
0.24
1.1
1.2
—
—
—
0
0
10
78
1.28
0.24
1.8
2.0
—
—
—
0
0
10
78
1.28
0.24
1.1
1.2
—
0.32
—
0
7
38
341
1.12
0.23
1.2
1.7
—
—
—
0
0
28
246
1.14
0.23
1.2
1.1
7.51
2.32
u/ml
—
10
96
428
4169
1.03
0.23
3.3
2.9
503.80
536.23
mosm/kgh2o
2.78
376
3592
897
8832
1.03
0.23
11.3
9.8
0.00
0.00
e9/l
1.48
750
7194
22
190
1.16
0.23
1.5
1.5
0.25
0.27
nmol/l
0.07
13
142
22
190
1.16
0.23
1.1
1.1
—
—
—
0
0
14
168
0.83
0.22
1.6
1.2
—
—
—
0
0
23
200
1.15
0.22
1.7
1.6
—
—
—
0
0
22
191
1.15
0.22
1.3
1.4
31.44
31.36
%
—
9
120
179
1865
0.96
0.21
5.6
6.7
1.40
1.37
mmol/l
0.14
174
1820
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
12.74
—
0
10
0
10
0.00
0.21
0.0
3.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
6.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
33.66
—
0
10
0
12
0.00
0.21
0.0
6.4
—
—
—
0
0
25
283
0.88
0.21
3.2
4.7
348.17
357.32
umol/l
0.08
18
247
8
104
0.77
0.21
2.0
1.3
240.17
345.44
u/l
—
8
95
11
89
1.24
0.21
1.8
1.4
159.55
162.36
pmol/l
0.02
11
89
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
35
318
1.10
0.18
1.1
1.1
139.50
69.37
iu/ml
—
7
70
144
1381
1.05
0.18
2.4
3.1
—
—
—
0
0
81
857
0.94
0.18
8.3
4.4
—
—
—
0
0
7
58
1.21
0.18
1.6
1.6
—
—
—
0
0
17
147
1.16
0.18
1.4
1.4
12.76
13.63
u/l
0.26
17
139
336
3280
1.03
0.17
3.2
2.9
1.80
2.57
e6/l
1.92
177
1794
8
70
1.14
0.16
1.1
2.0
—
—
—
0
0
39
360
1.08
0.16
1.2
1.6
—
—
—
0
0
21
235
0.89
0.16
1.8
1.6
—
—
—
0
0
359
3517
1.02
0.15
3.0
2.7
1.02
1.26
e6/l
0.76
202
2016
51
479
1.07
0.14
1.3
1.2
—
—
—
0
0
256
2499
1.03
0.14
1.7
1.6
—
—
—
0
0
14
122
1.15
0.13
1.2
1.3
—
—
—
0
0
31
286
1.09
0.13
1.2
1.1
—
—
—
0
0
39
365
1.07
0.12
1.2
1.7
—
—
—
0
0
12
104
1.15
0.12
1.2
2.5
—
—
—
0
0
31
334
0.93
0.12
1.4
1.5
—
—
—
0
0
60
630
0.95
0.12
2.9
3.4
—
—
—
0
0
39
366
1.07
0.11
1.2
1.7
—
—
—
0
0
30
279
1.08
0.11
1.2
1.8
—
—
—
0
0
27
250
1.08
0.11
1.3
1.2
—
—
—
0
0
39
368
1.06
0.10
1.2
1.7
—
—
—
0
0
513
5189
0.99
0.10
1.4
1.4
—
—
—
0
0
38
402
0.94
0.10
5.0
3.8
40.47
33.48
u/ml
0.18
38
394
5
45
1.11
0.09
5.4
3.9
—
—
—
0
0
5
47
1.06
0.09
1.0
1.3
—
141.25
—
0
8
13
145
0.90
0.09
4.2
2.2
—
—
—
0
0
71
736
0.96
0.09
1.9
2.3
244.62
750.78
ug/l
1.12
66
695
6
55
1.09
0.09
1.3
1.6
—
—
—
0
0
15
136
1.10
0.08
1.7
1.5
179.13
83.74
umol/l
0.43
15
136
23
214
1.08
0.08
1.2
1.4
6.79
6.59
mmol/l
0.15
23
202
5
63
0.79
0.08
1.4
1.1
—
—
—
0
0
7
64
1.09
0.08
1.9
1.7
—
—
—
0
0
79
766
1.03
0.08
6.9
3.7
1.13
1.35
mmol/l
2.10
79
755
22
205
1.07
0.08
1.1
1.2
—
—
—
0
0
6
71
0.84
0.07
2.0
1.5
3.52
4.03
%
—
6
60
11
98
1.12
0.07
3.2
3.9
—
—
—
0
0
21
225
0.93
0.07
1.8
1.5
—
—
—
0
0
10
112
0.89
0.07
1.3
1.3
—
—
—
0
0
7
85
0.82
0.07
19.7
10.6
0.66
0.64
mmol/l
—
7
79
8
94
0.85
0.06
1.3
2.6
9.00
9.85
mmol/l
—
8
94
11
99
1.11
0.06
1.2
1.0
—
—
—
0
0
13
142
0.92
0.06
1.1
1.1
—
—
—
0
0
67
653
1.03
0.05
7.8
3.9
3.84
3.89
mmol/l
0.42
67
647
46
445
1.03
0.05
2.7
2.9
—
—
—
0
0
30
313
0.96
0.05
1.3
1.2
299.50
271.05
u/ml
0.22
18
175
408
4053
1.01
0.04
3.0
3.0
2.45
2.46
mmol/l
0.44
338
3583
35
338
1.04
0.04
1.5
1.4
—
—
—
0
0
70
713
0.98
0.03
2.9
3.1
0.34
0.26
g/l
0.23
29
276
58
568
1.02
0.03
1.1
1.1
—
—
—
0
0
40
390
1.03
0.02
4.6
2.9
—
—
—
0
0
86
872
0.99
0.02
1.6
1.5
—
—
—
0
0
31
319
0.97
0.02
1.0
1.1
—
—
—
0
0
39
399
0.98
0.02
1.3
1.2
—
—
—
0
0
11
117
0.94
0.01
1.5
2.3
—
—
—
0
0
14
133
1.05
0.01
1.0
1.1
28.43
33.93
mmol/l
0.63
14
117
20
193
1.04
0.01
1.2
1.4
—
29.82
—
0
11
40
393
1.02
0.01
1.3
1.3
59.33
61.14
mmol/l
0.13
33
315
215
2142
1.00
0.01
1.6
1.5
—
—
—
0
0
81
803
1.01
0.01
1.6
1.8
—
—
—
0
0
12
114
1.05
0.00
1.1
1.1
—
—
—
0
0
46
454
1.01
0.00
3.7
3.5
1777.58
778.93
u/ml
0.24
40
420
31
315
0.98
0.00
1.0
1.3
—
—
—
0
0
24
241
1.00
0.00
1.6
1.4
36603.92
104494.71
e6/l
0.97
12
139
27
271
1.00
0.00
1.2
1.2
2.00
5.17
u/ml
—
9
115
27
271
1.00
0.00
1.5
1.4
1102.55
1777.63
e6/l
1.74
20
190
68
685
0.99
0.00
1.1
1.1
—
—
—
0
0
11
106
1.04
0.00
1.2
1.0
—
—
—
0
0
12
116
1.03
0.00
1.7
1.4
—
—
—
0
0
17
168
1.01
0.00
1.5
2.6
9.81
11.11
%
0.65
17
168
17
168
1.01
0.00
1.1
2.1
—
—
—
0
0
66
656
1.01
0.00
15.9
9.9
—
—
—
0
0
59
588
1.00
0.00
1.3
1.2
—
—
—
0
0
79
788
1.00
0.00
3.9
3.4
111.95
1966.99
u/ml
0.84
67
674
26
263
0.99
0.00
1.2
1.3
—
—
—
0
0
39
393
0.99
0.00
1.2
1.2
47.74
53.27
u/ml
—
7
41
118
1177
1.00
0.00
1.3
1.4
—
—
—
0
0
11
107
1.03
0.00
3.0
1.6
—
—
—
0
0
22
217
1.01
0.00
1.6
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
9
97
0.93
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
259.50
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
22
220
1.00
-0.00
1.5
1.3
289.41
276.93
mosm/kgh2o
0.84
17
164
6
69
0.87
-0.00
1.7
1.4
19.73
26.19
%
—
6
63
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.6
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
25
250
1.00
-0.00
1.3
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
75
750
1.00
-0.00
2.0
2.0
21.00
21.69
s
0.80
59
669
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CHOROID and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CHOROID 0.835 [0.74, 0.94] 0.002
Birth year 0.994 [0.98, 1.0] 0.195

During the follow-up period (1.1.1998 — 31.12.2019), 842 out of 5914 females with CD2_BENIGN_CHOROID died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CHOROID 0.838 [0.73, 0.97] 0.016
Birth year 0.989 [0.98, 1.0] 0.023

During the follow-up period (1.1.1998 — 31.12.2019), 654 out of 3580 males with CD2_BENIGN_CHOROID died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CHOROID.

N-year risk Females Males
1 0.083% 0.147%
5 0.466% 1.013%
10 1.192% 2.645%
15 2.354% 4.999%
20 4.394% 8.679%

Relationships between endpoints

Index endpoint: CD2_BENIGN_CHOROID – Benign neoplasm: Choroid

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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