info icon

Benign leiomyoma with endometriosis

CD2_LEIOMYOMA_ENDOMETRIOSIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

  • N14_ENDOMETRIOSIS
20882

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

6504

6. Filter based on genotype QC (FinnGen only)

6504

Control definitions (FinnGen only)

Control conditions
not N14_ENDOMETRIOSIS

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF10

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 6504 6504 -
Unadjusted period prevalence (%) 2.22 2.22 -
Median age at first event (years) 43.97 43.97 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
5903
Matched controls
59030
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
62532
ICD-8 Finland
Other diseases of uterus, Endometriosis retro-cervicalis sive retrouterina
+∞
323.0
539
*
6173A
ICD-9 Finland
Endometriosis of pelvic peritoneum[ENDOMETRIOSIS SEROSAE PELVIS]
+∞
323.0
343
*
2180A
ICD-9 Finland
Uterine leiomyoma, Submucous leiomyoma of uterus
7.4
323.0
1619
2882
6171A
ICD-9 Finland
Endometriosis of ovary
+∞
323.0
660
*
6173B
ICD-9 Finland
Endometriosis of pelvic peritoneum[ENDOMETRIOSIS RETROUTERINA]
+∞
323.0
490
*
D25.1
ICD-10 Finland
Intramural leiomyoma of uterus
6.5
323.0
1345
2571
N80.0
ICD-10 Finland
Endometriosis of uterus
1220.6
323.0
1176
12
62530
ICD-8 Finland
Other diseases of uterus, Endometriosis ovarii
+∞
323.0
579
*
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
11843.6
323.0
999
*
N80.9
ICD-10 Finland
Endometriosis, unspecified
407.4
323.0
384
10
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
6.5
323.0
2014
4336
N80.1
ICD-10 Finland
Endometriosis of ovary
2685.6
323.0
1154
5
21899
ICD-8 Finland
Uterine fibroma
7.8
323.0
1224
1917
6170A
ICD-9 Finland
Endometriosis of uterus
+∞
323.0
514
*
62533
ICD-8 Finland
Other diseases of uterus, Adenomyosis uteri
+∞
317.6
302
*
N80.4
ICD-10 Finland
Endometriosis of rectovaginal septum and vagina
1650.0
316.2
305
*
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
58.8
209.5
248
44
D25.0
ICD-10 Finland
Submucous leiomyoma of uterus
4.7
184.1
683
1598
LCD00
NOMESCO Finland
Hysterectomy
4.1
183.5
788
2126
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
4.5
173.6
680
1676
62531
ICD-8 Finland
Other diseases of uterus, Endometriosis serosae pelvis
+∞
167.5
160
*
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
2.3
166.6
4482
34234
8341
FHL
Colony removal or incineration
151.4
153.1
162
11
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
3.1
151.0
953
3456
D25.2
ICD-10 Finland
Subserosal leiomyoma of uterus
5.8
135.5
405
734
8306
FHL
Hysterectomy (related to abortion 8516, prolapse correction 8436)
4.1
132.6
568
1507
62538
ICD-8 Finland
Other diseases of uterus, Endometriosis alia
+∞
127.5
122
*
8201
FHL
Ovarian preservation exploration and related procedures, eg resection, enucleation or ovariolysis
7.9
124.0
297
395
1413
FHL
Laparoscopy and other therapeutic procedure
5.5
123.8
392
760
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
2.6
121.7
1041
4513
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.7
113.9
892
3661
LAF00
NOMESCO Finland
Unilateral salpingo-oophorectomy
8.7
109.2
245
293
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
10.4
103.5
209
207
N80.8
ICD-10 Finland
Other endometriosis
+∞
101.3
97
*
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
12.2
100.3
187
158
JAH01
NOMESCO Finland
Laparoscopy
3.7
99.2
464
1319
121
Kela drug reimbursment
Severe hypofunction of sexual glands
6.3
98.9
276
456
LAF01
NOMESCO Finland
Laparoscopic unilateral salpingo-oophorectomy
5.1
98.7
332
687
N80.5
ICD-10 Finland
Endometriosis of intestine
+∞
95.0
91
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
91.7
2247
14964
6178X
ICD-9 Finland
Endometriosis of other specified sites
+∞
86.7
83
*
LAC01
NOMESCO Finland
Laparoscopic excision of ovarian cyst
9.6
85.7
180
192
6146A
ICD-9 Finland
Inflammatory disease of ovary, Fallopian tube, pelvic cellular tissue and peritoneum, Pelvic peritoneal adhesions, female
7.1
83.4
213
311
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
6.7
81.2
216
334
B02AA02
ATC
tranexamic acid; systemic
2.0
80.0
1271
7188
8308
FHL
Hysterectomy and bilateral adnexal removal
4.6
79.7
293
665
8307
FHL
Hysterectomy and unilateral removal of adhesions
7.1
79.3
202
294
8305
FHL
Supravaginal amputation or resection
4.5
79.0
299
698
G03DC03
ATC
lynestrenol; oral
4.9
78.7
269
565
LAC21
NOMESCO Finland
Laparoscopic destruction of lesion of ovary
16.8
78.4
127
77
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
77.7
1471
8861
N94.5
ICD-10 Finland
Secondary dysmenorrhoea
6.7
77.5
205
315
8204
FHL
Salpingo-oophorectomy
6.3
76.4
213
351
N97.9
ICD-10 Finland
Female infertility, unspecified
3.7
75.4
357
1021
N80.89
ICD-10 Finland
Endometriosis with other specified or multiple localization
727.2
73.3
72
*
N97.8
ICD-10 Finland
Female infertility of other origin
9.6
72.4
152
162
1410
FHL
Laparoscopy
3.7
70.5
331
939
LBE01
NOMESCO Finland
Laparoscopic salpingectomy
4.6
68.1
246
548
62539
ICD-8 Finland
Other diseases of uterus, Endometriosis NUD
+∞
65.7
63
*
LCB11
NOMESCO Finland
Laparoscopic myomectomy
17.7
65.0
103
59
H01CA02
ATC
nafarelin; nasal
4.4
63.8
240
557
N80.81
ICD-10 Finland
Endometriosis in sacrouteral ligament
+∞
63.6
61
*
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.6
62.8
484
1930
N80.2
ICD-10 Finland
Endometriosis of fallopian tube
+∞
62.6
60
*
LCB10
NOMESCO Finland
Myomectomy
12.1
61.9
115
97
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
61.3
2173
15594
61610
ICD-8 Finland
Diseases of parametrium and pelvic peritoneum (female), Pelvic peritoneal adhesions, female
5.3
58.9
188
366
G03FA01
ATC
norethisterone and estrogen; systemic (progestogens and estrogens, fixed comb.)
0.5
57.8
481
9125
N99.4
ICD-10 Finland
Postprocedural pelvic peritoneal adhesions
7.3
57.3
142
199
8302
FHL
Tumor removal (e.g., enucleation) or polyp removal
7.5
56.8
138
188
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.0
55.1
843
4626
LBE20
NOMESCO Finland
Laparoscopic bilateral salpingectomy
6.5
55.0
148
233
G03GA01
ATC
chorionic gonadotrophin; parenteral
3.3
51.6
275
860
8351
FHL
Removal of pelvic floor brackets
8.1
51.5
119
150
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
3.3
50.2
269
845
LCD11
NOMESCO Finland
Laparoscopically assisted vaginal hysterectomy
4.2
49.4
195
474
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
47.8
2164
16196
L02AE03
ATC
goserelin; implant
7.8
47.3
111
144
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
2.6
46.9
367
1471
G03GA02
ATC
human menopausal gonadotrophin; parenteral
3.9
46.6
203
540
G03DA04
ATC
progesterone; systemic, rectal, vaginal
2.6
45.9
345
1352
L02AE02
ATC
leuprorelin; implant, parenteral
6.4
44.2
120
192
62800
ICD-8 Finland
Sterility, female, Sterilitas primaria
4.2
43.1
169
409
G03GA06
ATC
follitropin beta; parenteral
3.7
42.5
196
548
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.5
41.0
473
8230
8113
FHL
Fractional scraping
1.9
39.5
646
3605
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
38.9
1495
10660
G03XB02
ATC
ulipristal; oral (progesterone receptor modulators)
11.2
38.7
74
67
N80
ICD-10 Finland
Endometriosis
29.1
38.6
52
18
M01AE02
ATC
naproxen; oral, rectal
1.4
38.3
3270
27430
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
36.3
632
3597
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
4.4
34.7
128
293
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.1
34.4
410
2019
G03FB05
ATC
norethisterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
0.6
33.9
435
7387
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
0.6
33.3
576
9084
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
33.2
1282
9092
XLA10
NOMESCO Finland
NA
2.0
33.1
448
2324
N94.6
ICD-10 Finland
Dysmenorrhoea, unspecified
5.4
32.7
101
191
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
2.2
32.7
339
1566
LCF01
NOMESCO Finland
Laparoscopic excision of lesion of parametrium
37.5
32.4
41
11
8343
FHL
Combined endometriosis surgery
318.7
31.9
32
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
31.6
2231
17824
A02BC05
ATC
esomeprazole; systemic
1.4
30.9
2414
19612
G03GA05
ATC
follitropin alfa; parenteral
3.5
30.6
150
442
6289A
ICD-9 Finland
Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD PRIM]
5.4
29.6
91
172
LCD97
NOMESCO Finland
Other laparoscopic hysterectomy
9.9
28.8
58
59
355
Kela drug reimbursment
Dienogest
293.3
28.8
29
*
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
1.9
28.7
455
2499
LCG31
NOMESCO Finland
Laparoscopic resection or transcision of sacrouterine ligaments
150.7
28.7
30
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
28.6
432
2332
L02AE01
ATC
buserelin; implant, nasal, parenteral
4.2
28.5
111
269
LEF13
NOMESCO Finland
Colpoperineoplasty and vaginal hysterectomy
0.2
28.5
33
1497
N02AX02
ATC
tramadol; systemic, rectal
1.4
28.3
2243
18173
LAD00
NOMESCO Finland
Partial excision of ovary
17.7
28.3
44
25
LCC10
NOMESCO Finland
Supravaginal hysterectomy
5.7
28.1
82
146
G03FA12
ATC
medroxyprogesterone and estrogen; systemic (progestogens and estrogens, fixed comb.)
0.4
28.0
139
3185
N81.2
ICD-10 Finland
Incomplete uterovaginal prolapse
0.4
27.7
102
2626
N83.1
ICD-10 Finland
Corpus luteum cyst
4.2
27.5
107
259
LCD10
NOMESCO Finland
Vaginal hysterectomy
2.2
27.5
304
1448
G03DB08
ATC
dienogest; oral
+∞
27.1
26
*
LAC00
NOMESCO Finland
Excision of ovarian cyst
10.5
26.7
52
50
G03FB06
ATC
medroxyprogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
0.6
26.5
361
6066
6421
FHL
Appendicectomy
2.0
26.4
334
1684
G03AC03
ATC
levonorgestrel; systemic
0.6
26.2
386
6359
6202X
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Other and unspecified ovarian cyst
3.1
26.1
145
471
N70.1
ICD-10 Finland
Chronic salpingitis and oophoritis
3.7
25.4
115
319
LAC20
NOMESCO Finland
Destruction of lesion of ovary
19.1
25.2
38
20
LCB14
NOMESCO Finland
Laparoscopic myolysis
3.6
24.9
116
330
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
24.7
1522
11743
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.6
24.6
668
4321
A02BC02
ATC
pantoprazole; systemic
1.3
24.5
3738
33262
6200A
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Follicular cyst of ovary
4.5
24.3
87
195
61520
ICD-8 Finland
Other diseases of ovary and Fallopian tube, Cysta (cystis) follicularis ovarii (retentio)
3.0
24.1
140
469
J02AC01
ATC
fluconazole; systemic
1.3
24.0
2724
23155
N80.6
ICD-10 Finland
Endometriosis in cutaneous scar
+∞
24.0
23
*
N94.4
ICD-10 Finland
Primary dysmenorrhoea
5.1
23.2
74
147
A02BA02
ATC
ranitidine; systemic
1.4
22.9
1111
8180
N02BE01
ATC
paracetamol; systemic, rectal
1.4
22.8
5047
47375
LAD01
NOMESCO Finland
Laparoscopic partial excision of ovary
13.0
22.8
40
31
ZXE00
NOMESCO Finland
One hour or less
1.3
22.3
2147
17747
M01AH05
ATC
etoricoxib; oral
1.3
22.1
3321
29241
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
3.6
21.8
100
282
G03FA14
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, fixed comb.)
0.5
21.8
158
3183
LBE00
NOMESCO Finland
Salpingectomy
4.8
21.6
73
155
M01AG02
ATC
tolfenamic acid; oral, rectal
1.4
21.6
1006
7341
G03GB02
ATC
clomifene; oral
2.5
21.5
172
701
6288A
ICD-9 Finland
Infertility, female, Of other specified origin[STERILITAS ET INFERTILITAS MULIERIS ALIA PRIM]
12.3
21.3
38
31
P01AB01
ATC
metronidazole; oral, rectal
1.3
21.1
2392
20193
R2110
NOMESCO Finland
Giving the first information
1.7
21.1
428
2549
6262A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Excessive or frequent menstruation[HYPERMENORRHOEA]
2.1
21.0
235
1124
6175A
ICD-9 Finland
Endometriosis of intestine
+∞
20.8
20
*
LCA06
NOMESCO Finland
Biopsy of endometrium
1.5
20.7
914
6594
N83.0
ICD-10 Finland
Follicular cyst of ovary
3.1
20.5
114
373
LAE11
NOMESCO Finland
Unilateral laparoscopic oophorectomy
5.1
20.0
63
124
N95.0
ICD-10 Finland
Postmenopausal bleeding
0.6
19.7
309
5035
62400
ICD-8 Finland
Malposition of uterus, Retroversion and retroflexion
4.1
19.7
76
185
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
2.9
19.6
124
440
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
19.6
2046
17017
JAL97
NOMESCO Finland
Other laparoscopic excision of lesion of peritoneum
16.4
19.6
31
19
62660
ICD-8 Finland
Disorders of menstruation, Intermenstrual bleeding
2.0
19.3
252
1286
1411
FHL
Laparoscopy and cyst puncture
6.0
19.3
53
89
N97.1
ICD-10 Finland
Female infertility of tubal origin
4.5
19.2
68
152
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.8
19.2
339
1931
G03GA04
ATC
urofollitropin; parenteral
4.3
19.0
71
168
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.8
18.6
1570
19028
8202
FHL
Oophorectomy
5.8
18.2
51
88
N06AA09
ATC
amitriptyline; systemic
1.5
18.2
614
4173
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
3.5
18.2
85
245
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.8
18.0
325
1861
6172A
ICD-9 Finland
Endometriosis of Fallopian tube
+∞
17.7
17
*
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
2.2
17.7
192
908
8342
FHL
Cleavage and resection of sacrouterines
180.5
17.5
18
*
R01AD08
ATC
fluticasone; nasal
1.3
17.4
1549
12549
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
1.8
17.2
309
1769
J01DB01
ATC
cefalexin; oral
1.3
17.0
4518
42109
D39.10
ICD-10 Finland
Tumor of uncertain or unknown nature in the ovary without histology
2.1
16.5
191
930
62620
ICD-8 Finland
Disorders of menstruation, Excessive
2.3
16.4
147
636
G03FB08
ATC
dydrogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
0.5
16.0
179
3178
UKC02
NOMESCO Finland
Cystoscopy
1.5
15.8
556
3813
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
1.8
15.8
280
1599
N80.80
ICD-10 Finland
Bladder endometriosis
+∞
15.6
15
*
62550
ICD-8 Finland
NA
3.4
15.6
75
222
SPAT1153
SPAT
Removal of sutures
1.3
15.5
1703
14150
8349
FHL
Other measure in this category
160.4
15.5
16
*
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.7
15.4
377
5587
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
1.9
15.2
220
1172
N39.3
ICD-10 Finland
Stress incontinence
1.5
15.2
545
3753
K66.0
ICD-10 Finland
Peritoneal adhesions
4.2
15.1
56
133
M03BX02
ATC
tizanidine; oral
1.2
15.0
3459
31359
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.2
15.0
2588
22700
62699
ICD-8 Finland
Disorders of menstruation, Other
1.9
15.0
218
1164
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
4.3
14.9
54
125
H02AB06
ATC
prednisolone; systemic
1.2
14.9
2469
21553
R01AD09
ATC
mometasone; nasal
1.2
14.7
2458
21463
H01CC01
ATC
ganirelix; parenteral
2.7
14.7
99
367
UJF32
NOMESCO Finland
Coloscopy
1.3
14.5
1360
11043
LCA30
NOMESCO Finland
Transfer of oocyte or embryo to uterus in assisted fertilisation
5.2
14.2
43
83
A03CA02
ATC
clidinium and psycholeptics; oral
1.6
14.1
344
2155
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
2.9
14.0
86
302
J01AA02
ATC
doxycycline; systemic
1.3
13.9
4497
42206
M70.6
ICD-10 Finland
Trochanteric bursitis
1.4
13.8
838
6369
M79.7
ICD-10 Finland
Fibromyalgia
1.8
13.8
220
1215
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.6
13.7
200
3317
62630
ICD-8 Finland
Disorders of menstruation, Painful
2.9
13.7
80
274
N93.8
ICD-10 Finland
Other specified abnormal uterine and vaginal bleeding
2.4
13.4
116
497
G44.2
ICD-10 Finland
Tension-type headache
1.4
13.4
732
5461
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
13.4
1849
15739
J01FA10
ATC
azithromycin; systemic
1.2
13.4
3179
28739
61521
ICD-8 Finland
Other diseases of ovary and Fallopian tube, Cysta (cystis) corporis lutei ovarii
3.3
13.3
65
196
M01AB05
ATC
diclofenac; systemic, rectal
1.2
13.1
3633
33350
J02AC02
ATC
itraconazole; systemic
1.3
13.1
1016
8019
G02BA03
ATC
plastic IUD with progestogen
0.7
13.1
336
4934
1350
FHL
Hysteroscopy
2.7
13.0
90
342
M54.5
ICD-10 Finland
Low back pain
1.3
12.9
1710
14469
N06AB04
ATC
citalopram; systemic
1.3
12.7
1170
9455
XF402
NOMESCO Finland
ECG with work load test
1.5
12.4
511
3617
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
1.7
12.4
271
1649
WX402
NOMESCO Finland
General anaesthesia
1.4
12.4
788
6028
M01AH01
ATC
celecoxib; oral (coxibs)
1.3
12.3
1034
8250
C07AB07
ATC
bisoprolol; oral
1.2
12.3
2334
20533
6289B
ICD-9 Finland
Infertility, female, Of unspecified origin[STERILITAS ET INFERTILITAS MULIERIS NUD SEC]
3.7
12.3
53
146
A02BC01
ATC
omeprazole; systemic
1.3
12.0
1436
11987
L02AB02
ATC
medroxyprogesterone; systemic (progestogens)
3.6
12.0
52
144
N03AX16
ATC
pregabalin; oral
1.3
11.8
1250
10278
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
11.7
3019
27345
TLW12
NOMESCO Finland
Insertion of frozen embryo
3.4
11.7
55
162
TLW10
NOMESCO Finland
Transfer of fresh embryo
3.3
11.7
58
178
W12
ICPC
Contraception intrauterine
0.5
11.7
112
2074
A03FA02
ATC
cisapride; oral, rectal
1.5
11.6
429
2971
A02BC03
ATC
lansoprazole; oral
1.2
11.6
1581
13392
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
11.5
1476
12413
6179X
ICD-9 Finland
Endometriosis, site unspecified
+∞
11.5
11
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.3
11.4
1137
9266
J01FA09
ATC
clarithromycin; systemic
1.2
11.4
1690
14444
M79.6
ICD-10 Finland
Pain in limb
1.2
11.4
1964
17064
M79.0
ICD-10 Finland
Rheumatism, unspecified
1.7
11.4
241
1456
M01AX05
ATC
glucosamine; oral
1.3
11.3
1264
10460
C07AA05
ATC
propranolol; systemic
1.3
11.3
1025
8258
ULC02
NOMESCO Finland
Hysteroscopy
1.5
11.2
365
2460
N95.1
ICD-10 Finland
Menopausal and female climacteric states
1.4
11.2
620
4632
2200A
ICD-9 Finland
Benign neoplasm of ovary[NEOPLASMA BENIGNUM OVARII]
2.5
11.1
88
361
D25
ICD-10 Finland
Leiomyoma of uterus
2.6
11.1
79
308
M01AH02
ATC
rofecoxib; oral
1.3
11.1
732
5632
N06AX21
ATC
duloxetine; oral
1.4
11.1
564
4153
N92.4
ICD-10 Finland
Excessive bleeding in the premenopausal period
1.6
10.9
255
1583
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.3
10.8
971
7801
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
10.8
1320
11026
LAE10
NOMESCO Finland
Unilateral oophorectomy
4.2
10.7
39
93
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
10.6
839
6619
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
10.6
2563
22977
N06AX16
ATC
venlafaxine; oral
1.3
10.4
679
5204
M03BC51
ATC
orphenadrine, combinations; systemic
1.2
10.4
1490
12668
ZXE20
NOMESCO Finland
More than three and less than five hours
1.4
10.3
602
4537
6266A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Metrorrhagia
1.6
10.3
266
1697
M01AE01
ATC
ibuprofen; systemic, rectal
1.3
10.3
5034
48349
J01DA01
ATC
[U] cefalexin; systemic
1.2
10.3
3376
31120
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
10.2
2241
19886
LCA10
NOMESCO Finland
Curettage of body of uterus
1.8
10.2
183
1055
M01AX17
ATC
nimesulide; oral
1.2
10.2
1364
11506
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
10.2
1144
9454
N97.2
ICD-10 Finland
Female infertility of uterine origin
13.1
10.1
17
13
R51.80
ICD-10 Finland
Headache
1.3
10.1
703
5445
J01CA08
ATC
pivmecillinam; oral
1.2
10.1
2918
26557
O34.1
ICD-10 Finland
Maternal care for tumour of corpus uteri
4.1
10.1
38
94
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
10.1
1178
9778
6253A
ICD-9 Finland
Pain and other symptoms associated with female genital organs, Dysmenorrhoea
3.3
10.0
48
145
D01
ICPC
Abdominal pain/cramps general
1.4
10.0
505
3715
LEG10
NOMESCO Finland
Vaginal urethrocystopexy
1.7
10.0
190
1115
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.4
10.0
590
4458
M01AG01
ATC
mefenamic acid; oral
1.9
9.8
150
820
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.4
9.8
436
3137
R03AC02
ATC
salbutamol; inhalant
1.2
9.8
2811
25545
LAG01
NOMESCO Finland
Laparoscopic freeing of adhesions of ovary
10.6
9.8
18
17
E
ICD-9 Finland
NA
3.8
9.7
40
107
J01MA01
ATC
ofloxacin; systemic
1.5
9.7
367
2554
SPAT1308
SPAT
Sexual health counselling
0.6
9.7
123
2110
K07.60
ICD-10 Finland
Snapping jaw
1.6
9.5
247
1577
LBE10
NOMESCO Finland
Bilateral salpingectomy
8.4
9.5
20
24
6288B
ICD-9 Finland
Infertility, female, Of other specified origin[STERILITAS ET INFERTILITAS MULIERIS ALIA SEC]
10.0
9.5
18
18
ZXD20
NOMESCO Finland
Day surgery
1.3
9.5
658
5093
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.3
9.5
653
5053
6282A
ICD-9 Finland
Infertility, female, Of tubal origin[STERIL ET INFERT EX ORIG TUBAE UTERINAE PRIM]
4.2
9.4
34
81
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
9.4
770
6101
62801
ICD-8 Finland
Sterility, female, Sterilitas secundaria
2.7
9.4
60
220
22099
ICD-8 Finland
Benign neoplasm of ovary, Other and unspecified
2.0
9.4
109
539
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.5
9.4
288
1918
6201A
ICD-9 Finland
Noninflammatory disorders of ovary, Fallopian tube and broad ligament, Corpus luteum cyst or haematoma
3.4
9.3
44
132
S18
ICPC
Laceration/cut
1.2
9.3
2091
18548
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
9.3
1205
10109
N03AX12
ATC
gabapentin; oral
1.3
9.3
774
6148
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.4
9.3
505
3761
UJF30
NOMESCO Finland
Ileoscopy through colon
1.4
9.3
453
3313
LBF00
NOMESCO Finland
Perfusion of Fallopian tube
4.2
9.2
33
78
N97.4
ICD-10 Finland
Female infertility associated with male factors
2.5
9.2
67
265
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.3
9.2
921
7492
8203
FHL
Salpingectomy
3.7
9.2
38
103
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
9.1
2325
20854
J01MA02
ATC
ciprofloxacin; systemic
1.2
9.1
1811
15875
Z2221
NOMESCO Finland
Medical doctor
1.2
9.1
1391
11878
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.4
9.0
539
4075
C05AA08
ATC
fluocortolone; rectal, topical
1.3
9.0
713
5629
N06AX11
ATC
mirtazapine; oral
1.2
9.0
1640
14257
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
1.6
8.9
200
1234
M02AA07
ATC
piroxicam; topical
1.2
8.9
2058
18287
6280A
ICD-9 Finland
Infertility, female, Associated with anovulation[STERILITAS ET INFERTILITAS ANOVULATORIA PRIM]
5.7
8.9
24
42
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
2.0
8.8
113
579
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.2
8.8
1195
10071
R06AE07
ATC
cetirizine; oral
1.2
8.8
2405
21681
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.5
8.7
326
2267
LA2JE
NOMESCO Finland
Follow-up of menstrual cycle with repeated measurement of ovarian cyst
4.4
8.7
30
69
SPAT1190
SPAT
Insertion or removal of intrauterine contraceptive device
0.5
8.7
58
1193
LCF96
NOMESCO Finland
Other excision of lesion of parametrium
50.0
8.7
10
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
0.7
8.7
219
3224
LDW96
NOMESCO Finland
Other operation on cervix uteri
4.8
8.6
27
56
N30.0
ICD-10 Finland
Acute cystitis
1.3
8.5
807
6514
LWW96
NOMESCO Finland
Other reoperation in gynaecological surgery
4.2
8.5
30
71
LCB97
NOMESCO Finland
Other laparoscopic excision of lesion of uterus
20.0
8.5
12
6
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
2.2
8.5
85
396
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.4
8.4
495
3736
L82
ICD-10 Finland
Seborrhoeic keratosis
1.3
8.4
815
6604
LAE21
NOMESCO Finland
Bilateral laparoscopic oophorectomy
4.2
8.4
30
72
6176A
ICD-9 Finland
Endometriosis in scar of skin
+∞
8.3
8
*
N02AJ06
ATC
codeine and paracetamol; systemic
1.2
8.2
1795
15845
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
2.3
8.1
70
306
62650
ICD-8 Finland
Disorders of menstruation, Irregular
2.0
8.1
94
467
D27.91
ICD-10 Finland
Benign epithelial tumor of the ovary (ovary)
2.1
8.0
89
431
WX002
NOMESCO Finland
Sedation and analgesia
1.2
8.0
980
8156
J01FA06
ATC
roxithromycin; oral
1.2
8.0
2174
19542
M19.9
ICD-10 Finland
Arthrosis, unspecified
1.6
7.9
203
1295
M25.5
ICD-10 Finland
Pain in joint
1.2
7.9
1499
13043
8219
FHL
Other measure in this category
4.7
7.9
25
53
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.4
7.9
422
3139
D06
ICPC
Abdominal pain localized other
1.4
7.8
385
2825
XF404
NOMESCO Finland
Ambulatory ECG
1.4
7.8
398
2937
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
2.5
7.7
58
236
LAE20
NOMESCO Finland
Bilateral oophorectomy
3.3
7.7
36
109
LAA31
NOMESCO Finland
Ovarioscopy
6.3
7.7
19
30
K30
ICD-10 Finland
Functional dyspepsia
1.3
7.7
534
4136
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.2
7.6
2084
18715
MAX99
NOMESCO Finland
Assistance to normal delivery
0.6
7.6
89
1554
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
1.4
7.6
314
2230
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.2
7.6
1542
13500
XKC03
NOMESCO Finland
Water cystometry
1.6
7.6
170
1049
G03FA17
ATC
drospirenone and estrogen; systemic
0.5
7.6
52
1059
Z30.0
ICD-10 Finland
General counselling and advice on contraception
0.5
7.6
58
1140
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
1.9
7.5
97
504
JHB00
NOMESCO Finland
Hemorrhoidectomy
1.7
7.5
158
961
G04BD08
ATC
solifenacin; oral
1.4
7.5
336
2422
21900
ICD-8 Finland
Other benign neoplasm of uterus, Papiloma, polyp
2.1
7.4
80
385
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
7.4
2028
18213
Z37.0
ICD-10 Finland
Single live birth
0.6
7.4
127
2019
M54.2
ICD-10 Finland
Cervicalgia
1.4
7.3
327
2355
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.2
7.3
1124
9581
6174A
ICD-9 Finland
Endometriosis of rectovaginal septum and vagina
+∞
7.3
7
*
G04BD12
ATC
mirabegron; oral
1.3
7.2
505
3913
G01AF04
ATC
miconazole; vaginal
1.4
7.2
316
2267
61620
ICD-8 Finland
Diseases of parametrium and pelvic peritoneum (female), Pelvic congestion, female
4.5
7.2
24
54
6561
FHL
Removal of fasteners and related measures
3.8
7.2
28
73
R05
ICD-10 Finland
Cough
1.2
7.2
959
8047
Z31.2
ICD-10 Finland
In vitrofertilization
3.4
7.2
32
94
LDC03
NOMESCO Finland
Conisation of cervix uteri using diathermy or laser
0.6
7.1
82
1441
L03
ICPC
Low back symptom/complaint
1.2
7.1
1236
10653
LWE00
NOMESCO Finland
Reoperation for deep haemorrhage in gynaecological surgery
3.1
7.1
36
116
R03DC03
ATC
montelukast; oral
1.2
7.1
813
6710
C08CA01
ATC
amlodipine; oral
1.2
7.1
1668
14772
R53
ICD-10 Finland
Malaise and fatigue
1.2
7.1
960
8070
A02BC04
ATC
rabeprazole; oral
1.4
7.1
409
3078
F20.9
ICD-10 Finland
Schizophrenia, unspecified
0.2
7.1
9
384
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
1.9
7.1
99
528
LAB01
NOMESCO Finland
Laparoscopic ovariotomy
12.0
7.1
12
10
R01AD01
ATC
beclometasone; nasal
1.3
7.1
767
6291
6210A
ICD-9 Finland
Disorders of uterus, not elsewhere classified, Polyp of corpus uteri
2.2
7.0
63
282
C09CA06
ATC
candesartan; oral
1.2
7.0
1067
9074
TLC02
NOMESCO Finland
Simple extraction of IUD
1.5
7.0
201
1322
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.4
7.0
375
2787
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.8
7.0
118
671
G04BD04
ATC
oxybutynin; oral, transdermal
1.4
7.0
295
2100
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
0.5
7.0
44
920
G01AF05
ATC
econazole; vaginal
1.3
7.0
527
4128
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.4
7.0
282
1994
1530
FHL
Urethrocystoscopy
2.2
7.0
65
296
WX110
NOMESCO Finland
Local anesthesy
1.2
7.0
3543
33308
N94.1
ICD-10 Finland
Dyspareunia
2.5
6.9
49
194
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
3.2
6.9
34
108
JN2CM
NOMESCO Finland
Lower part of abdomen extensive MRI examination with Tesla magnet
5.4
6.9
19
35
R00.2
ICD-10 Finland
Palpitations
1.4
6.9
353
2605
XKD03
NOMESCO Finland
Urethral pressure profilometry
1.7
6.8
141
853
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
6.8
2051
18521
R01AD12
ATC
fluticasone furoate; nasal
1.2
6.8
1452
12747
LAA06
NOMESCO Finland
Transvaginal puncture of ovarian cyst
2.8
6.8
41
149
R01AD05
ATC
budesonide; nasal
1.4
6.8
379
2839
F51.0
ICD-10 Finland
Nonorganic insomnia
1.3
6.8
593
4740
LAC11
NOMESCO Finland
Laparoscopic fenestration or marsupialisation of ovarian cyst
16.7
6.7
10
6
LCF97
NOMESCO Finland
Other laparoscopic excision of lesion of parametrium
16.7
6.7
10
6
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.3
6.7
590
4716
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.3
6.7
386
2908
R30.0
ICD-10 Finland
Dysuria
1.6
6.7
159
1001
JGB04
NOMESCO Finland
Laparoscopic partial proctectomy with partial excision of mesorectum
5.9
6.6
17
29
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.3
6.6
558
4442
A06AC51
ATC
ispaghula, combinations; systemic
1.4
6.6
250
1750
Z3231
NOMESCO Finland
Registered nurse
1.2
6.6
1255
10907
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.2
6.5
970
8229
M01AC06
ATC
meloxicam; systemic, rectal
1.2
6.5
2046
18520
M79.1
ICD-10 Finland
Myalgia
1.3
6.5
632
5117
L01
ICPC
Neck symptom/complaint
1.3
6.5
690
5647
N05BA12
ATC
alprazolam; oral
1.3
6.5
514
4055
R06AX27
ATC
desloratadine; oral
1.2
6.5
1335
11678
R01BA51
ATC
phenylpropanolamine, combinations; oral
1.3
6.5
509
4014
J01EA01
ATC
trimethoprim; systemic
1.2
6.4
1534
13585
N02CC03
ATC
zolmitriptan; nasal, oral
1.4
6.4
265
1883
M01AB01
ATC
indometacin; systemic, rectal
1.4
6.4
251
1767
M01AB55
ATC
diclofenac, combinations; oral
1.4
6.4
353
2640
A07AA02
ATC
nystatin; oral
1.4
6.4
317
2329
Z3226
NOMESCO Finland
Physiotherapist
1.2
6.4
871
7320
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
1.5
6.4
232
1605
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.3
6.4
464
3615
Z54.0
ICD-10 Finland
Convalescence following surgery
2.0
6.4
77
391
N03AX11
ATC
topiramate; oral
1.7
6.4
112
647
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.3
6.3
494
3892
B01AB05
ATC
enoxaparin; parenteral
1.2
6.3
1563
13877
N83.9
ICD-10 Finland
Noninflammatory disorder of ovary, fallopian tube and broad ligament, unspecified
3.3
6.3
29
88
R01AD11
ATC
triamcinolone; nasal
1.3
6.3
440
3412
Z2445
NOMESCO Finland
Psychologist
1.7
6.3
124
742
M01AH03
ATC
valdecoxib; oral
1.4
6.3
307
2250
SPAT1263
SPAT
Sampling
1.2
6.3
2123
19310
M54
ICD-10 Finland
Dorsalgia
1.3
6.3
505
3992
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.2
6.3
1122
9691
LCG30
NOMESCO Finland
Resection or transcision of sacrouterine ligaments
+∞
6.2
6
*
G03DC02
ATC
norethisterone; oral
1.2
6.2
815
6824
S01GX01
ATC
cromoglicic acid; ophthalmic
1.2
6.2
1036
8887
R52.9
ICD-10 Finland
Pain, unspecified
1.3
6.2
391
2987
R31
ICD-10 Finland
Unspecified haematuria
1.4
6.2
241
1696
JEA00
NOMESCO Finland
Appendectomy
1.4
6.2
249
1762
D27.99
ICD-10 Finland
Benign tumor of the ovary (ovary), unspecified histology
2.6
6.2
41
158
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.3
6.2
491
3877
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
0.2
6.2
8
337
8380/3-C54.1
ICD-O-3
Endometrioid adenocarcinoma, NOS, of endometrium
0.4
6.2
25
610
LEB10
NOMESCO Finland
Excision of lesion of vagina
2.8
6.2
36
128
Z09.9
ICD-10 Finland
Follow-up examination after unspecified treatment for other conditions
2.2
6.1
57
262
Q50.10
ICD-10 Finland
A developmental cyst in the ovary
2.3
6.1
53
234
N02CC04
ATC
rizatriptan; oral
1.4
6.1
282
2049
LAG00
NOMESCO Finland
Freeing of adhesions of ovary
12.5
6.1
10
8
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
0.4
6.0
31
695
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.3
6.0
445
3479
M54.4
ICD-10 Finland
Lumbago with sciatica
1.2
6.0
789
6610
XKD00
NOMESCO Finland
Uroflowmetry
1.5
6.0
214
1479
J01MA06
ATC
norfloxacin; oral
1.2
6.0
762
6360

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_LEIOMYOMA_ENDOMETRIOSIS – Benign leiomyoma with endometriosis

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).