uterine fibroid: A benign smooth muscle neoplasm arising from the body of the uterus. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleonly females |
293373 |
2. Check conditionsNone |
293373 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
43521 |
4. Check minimum number of eventsNone |
43521 |
5. Include endpointsNone |
43521 |
6. Filter based on genotype QC (FinnGen only) |
43521 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D10-D36
- Name in latin
- Leiomyoma uteri
Similar endpoints
↥List of similar endpoints to
Leiomyoma of uterus
based on the number of shared cases.
Similar with more cases:
- Leiomyoma of uterus
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 302635 | 302635 | - |
| Only index persons | 283123 | 283123 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 8.67 | 8.67 | - |
| Only index persons | 10.41 | 10.41 | - |
| Median age at first event (years) | |||
| Whole population | - | 46.91 | - |
| Only index persons | - | 46.75 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 43521 | 43521 | - |
| Unadjusted period prevalence (%) | 14.83 | 14.83 | - |
| Median age at first event (years) | 46.68 | 46.68 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 10545
- Matched controls
- 73639
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D25.0
ICD-10 Finland
Submucous leiomyoma of uterus
367.9
323.0
2513
62
21899
ICD-8 Finland
Uterine fibroma
+∞
323.0
485
*
LBE20
NOMESCO Finland
Laparoscopic bilateral salpingectomy
12.8
323.0
864
509
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
3.0
323.0
6219
23766
LCD01
NOMESCO Finland
Total laparoscopic hysterectomy
9.0
323.0
1041
889
B02AA02
ATC
tranexamic acid; systemic
3.4
323.0
3629
9789
LCB14
NOMESCO Finland
Laparoscopic myolysis
84.3
323.0
689
61
LCA06
NOMESCO Finland
Biopsy of endometrium
5.0
323.0
3758
7339
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
302.2
323.0
6433
379
D25.2
ICD-10 Finland
Subserosal leiomyoma of uterus
153.0
323.0
1307
68
LCD00
NOMESCO Finland
Hysterectomy
11.8
323.0
1035
672
D25.1
ICD-10 Finland
Intramural leiomyoma of uterus
114.7
323.0
3464
313
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
4.0
323.0
3164
7180
LCD04
NOMESCO Finland
Laparoscopic hysterectomy
9.6
323.0
1314
1077
G03XB02
ATC
ulipristal; oral (progesterone receptor modulators)
152.0
313.8
378
18
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
3.5
311.3
1793
4126
LCB10
NOMESCO Finland
Myomectomy
114.6
308.3
380
24
D25
ICD-10 Finland
Leiomyoma of uterus
14.9
295.3
556
274
LBE01
NOMESCO Finland
Laparoscopic salpingectomy
4.8
265.3
1017
1595
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
3.5
242.3
1356
3004
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.7
240.6
2055
6084
LCB11
NOMESCO Finland
Laparoscopic myomectomy
222.0
235.3
277
9
LCB25
NOMESCO Finland
Hysteroscopic excision of lesion
4.1
229.6
1027
1871
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
3.5
219.4
1189
2556
LCD10
NOMESCO Finland
Vaginal hysterectomy
5.2
197.1
696
986
LCD97
NOMESCO Finland
Other laparoscopic hysterectomy
118.8
189.6
233
14
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.3
173.0
2048
7071
2180A
ICD-9 Finland
Uterine leiomyoma, Submucous leiomyoma of uterus
+∞
171.1
189
*
N84.0
ICD-10 Finland
Polyp of corpus uteri
3.0
168.5
1154
2918
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
165.5
2551
9873
LBE00
NOMESCO Finland
Salpingectomy
10.9
153.4
330
218
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
137.5
3522
16175
N92.4
ICD-10 Finland
Excessive bleeding in the premenopausal period
3.0
123.6
802
1936
O80.0
ICD-10 Finland
Spontaneous vertex delivery
0.6
116.9
3597
33813
O34.1
ICD-10 Finland
Maternal care for tumour of corpus uteri
10.6
116.3
252
169
N02BE01
ATC
paracetamol; systemic, rectal
1.8
113.4
8740
53681
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
0.6
109.6
2539
25605
WX402
NOMESCO Finland
General anaesthesia
1.9
107.3
1799
7032
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
107.1
2524
11100
ULC02
NOMESCO Finland
Hysteroscopy
2.6
105.7
896
2549
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.9
101.7
1744
6860
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.8
100.1
2030
8468
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.6
98.8
3805
19156
B01AB05
ATC
enoxaparin; parenteral
1.7
97.1
2408
10704
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
3.3
90.6
517
1133
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
87.6
1116
3875
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
0.6
86.3
1373
15383
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
84.9
3724
19156
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
2.1
84.0
1080
3762
TLC02
NOMESCO Finland
Simple extraction of IUD
2.1
77.9
985
3400
N80.1
ICD-10 Finland
Endometriosis of ovary
2.5
74.3
677
1994
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
3.0
73.1
468
1112
LCD11
NOMESCO Finland
Laparoscopically assisted vaginal hysterectomy
7.9
71.4
181
162
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.7
70.3
1990
9067
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
1.9
69.5
1192
4633
ZXE20
NOMESCO Finland
More than three and less than five hours
2.0
68.9
1014
3720
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
0.6
68.1
1427
15102
N80.3
ICD-10 Finland
Endometriosis of pelvic peritoneum
2.3
67.7
681
2107
MAX99
NOMESCO Finland
Assistance to normal delivery
0.5
66.1
576
7703
LBE10
NOMESCO Finland
Bilateral salpingectomy
25.4
64.7
101
28
N80.0
ICD-10 Finland
Endometriosis of uterus
2.9
64.5
447
1118
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.9
61.4
413
1013
W78
ICPC
Pregnancy
0.5
59.6
764
9166
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
4.7
59.3
222
333
SPAT1197
SPAT
Extensive health check-up of expecting family
0.5
59.3
636
8014
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
0.6
58.5
1271
13410
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
57.3
2891
15013
Z39.2
ICD-10 Finland
Routine postpartum follow-up
0.6
52.1
867
9765
LCA10
NOMESCO Finland
Curettage of body of uterus
2.5
50.6
431
1220
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
0.6
49.3
1009
10841
SPAT1196
SPAT
Monitoring of normal pregnancy
0.5
47.2
375
5192
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
3.3
47.1
262
563
PD2DT
NOMESCO Finland
Embolisation of gynekological tumor
193.6
46.6
55
*
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
46.3
317
786
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
5.3
45.9
154
205
R19.0
ICD-10 Finland
Intra-abdominal and pelvic swelling, mass and lump
3.0
45.7
288
676
D39.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Uterus
7.1
44.8
121
121
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
0.5
44.5
491
6169
LDA00
NOMESCO Finland
Dilatation of cervix uteri
4.4
44.2
176
283
P01AB01
ATC
metronidazole; oral, rectal
1.3
42.7
4316
25035
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
42.5
2876
15606
LCB98
NOMESCO Finland
Other transluminal endoscopic excision of lesion of uterus
3.8
42.1
198
372
SPAT1308
SPAT
Sexual health counselling
0.6
41.4
836
9045
WX307
NOMESCO Finland
Obstetric epidural analgesia
0.5
41.3
386
5094
Z30.4
ICD-10 Finland
Surveillance of contraceptive drugs
0.4
41.2
227
3561
X78
ICPC
Fibromyoma uterus
27.2
40.7
62
16
LAF10
NOMESCO Finland
Bilateral salpingo-oophorectomy
3.4
39.5
207
426
B01AB10
ATC
tinzaparin; parenteral
2.1
39.4
483
1633
Z37.0
ICD-10 Finland
Single live birth
0.6
38.0
900
9424
LAF01
NOMESCO Finland
Laparoscopic unilateral salpingo-oophorectomy
2.3
37.8
391
1222
R2110
NOMESCO Finland
Giving the first information
1.7
36.7
927
4033
SPAT1380
SPAT
Postpartum check-up
0.5
36.3
393
4978
SPAT1379
SPAT
Health check-up of pregnant person
0.6
35.4
504
5934
LCA13
NOMESCO Finland
Curettage of cervix and body of uterus
2.1
34.9
425
1433
WX704
NOMESCO Finland
Intubation
1.8
34.9
632
2479
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
34.8
9502
63185
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
34.0
579
2225
LAF00
NOMESCO Finland
Unilateral salpingo-oophorectomy
3.4
33.2
173
355
W12
ICPC
Contraception intrauterine
0.6
33.2
850
8777
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
0.7
32.6
1046
10351
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.7
32.5
250
668
LCB20
NOMESCO Finland
Transvaginal myomectomy
39.4
32.1
45
8
W11
ICPC
Contraception oral
0.5
31.8
323
4170
Z2221
NOMESCO Finland
Medical doctor
1.3
31.3
2760
15476
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.8
30.9
545
2118
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
0.4
30.8
159
2556
N95.1
ICD-10 Finland
Menopausal and female climacteric states
1.4
30.4
1713
8909
O81.4
ICD-10 Finland
Vacuum extractor delivery
0.6
29.8
455
5279
8302
FHL
Tumor removal (e.g., enucleation) or polyp removal
19.1
29.3
49
18
D39.10
ICD-10 Finland
Tumor of uncertain or unknown nature in the ovary without histology
2.3
29.3
283
858
C08CA01
ATC
amlodipine; oral
1.4
27.9
1467
7522
SPAT1190
SPAT
Insertion or removal of intrauterine contraceptive device
0.6
27.8
446
5113
JAH01
NOMESCO Finland
Laparoscopy
1.7
25.7
599
2539
MAE00
NOMESCO Finland
Outlet vacuum delivery
0.6
25.3
367
4316
Z3232
NOMESCO Finland
Midwife
0.7
25.3
773
7746
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.6
25.2
721
3233
LCC10
NOMESCO Finland
Supravaginal hysterectomy
8.3
24.6
59
50
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
0.6
24.5
609
6352
N94.5
ICD-10 Finland
Secondary dysmenorrhoea
2.0
24.0
330
1170
Z34
ICD-10 Finland
Supervision of normal pregnancy
0.5
23.1
200
2707
X06
ICPC
Menstruation excessive
2.2
23.0
243
772
N93.9
ICD-10 Finland
Abnormal uterine and vaginal bleeding, unspecified
2.0
22.6
297
1036
JN2BG
NOMESCO Finland
MRI examination of lower part of abdoment with high intensity magnet
4.3
22.3
88
143
ZXA10
NOMESCO Finland
Bilateral
1.4
21.7
1198
6177
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.2
21.6
233
747
ZXC40
NOMESCO Finland
Use of ultrasound
4.0
21.5
91
158
A02BC02
ATC
pantoprazole; systemic
1.2
21.2
5552
35074
TMA00
NOMESCO Finland
Episiotomy
0.5
20.4
160
2229
G03DC03
ATC
lynestrenol; oral
1.9
20.3
330
1248
ZXD20
NOMESCO Finland
Day surgery
1.4
20.1
1151
5969
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
0.8
20.1
1305
11640
W90
ICPC
Uncompl labour/delivery livebirth
0.5
20.0
148
2105
N99.4
ICD-10 Finland
Postprocedural pelvic peritoneal adhesions
3.1
20.0
118
268
N02AX02
ATC
tramadol; systemic, rectal
1.2
19.9
3106
18526
N920, D259
ICD-10 Finland
NA
+∞
19.9
22
*
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
0.7
19.8
906
8506
62533
ICD-8 Finland
Other diseases of uterus, Adenomyosis uteri
11.4
19.4
39
24
LDB00
NOMESCO Finland
Excision of lesion of cervix uteri
2.4
19.4
171
497
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.2
19.0
3470
21028
N921, D250
ICD-10 Finland
NA
+∞
19.0
21
*
LBF01
NOMESCO Finland
Laparoscopic perfusion of Fallopian tube
1.9
18.8
295
1104
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
0.7
18.8
854
8026
XMA22
NOMESCO Finland
General examination of pregnant woman
0.7
18.2
614
6064
N73.6
ICD-10 Finland
Female pelvic peritoneal adhesions
2.5
18.1
155
445
M01AH05
ATC
etoricoxib; oral
1.2
17.8
5611
35806
N93.8
ICD-10 Finland
Other specified abnormal uterine and vaginal bleeding
2.1
17.8
224
771
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
0.7
17.6
727
6941
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
17.4
1337
7263
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
1.2
17.4
2570
15188
UJF32
NOMESCO Finland
Coloscopy
1.3
17.3
1462
8053
JAL21
NOMESCO Finland
Laparoscopic excision or destruction of lesion of peritoneum
2.0
17.2
234
830
SPAT1153
SPAT
Removal of sutures
1.3
17.2
1859
10586
ZXE00
NOMESCO Finland
One hour or less
1.2
16.8
3609
22161
SPAT1193
SPAT
Pap smear
0.7
16.7
988
8941
D50
ICD-10 Finland
Iron deficiency anaemia
2.1
16.4
205
705
WX725
NOMESCO Finland
Noninvasive ventilation
1.8
16.0
313
1262
N25.9
ICD-10 Finland
Disorder resulting from impaired renal tubular function, unspecified
38.5
15.9
22
*
N80.9
ICD-10 Finland
Endometriosis, unspecified
1.8
15.8
306
1231
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
0.7
15.7
847
7773
O48
ICD-10 Finland
Prolonged pregnancy
0.6
15.6
210
2513
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.5
15.5
512
2377
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
2.2
15.5
159
502
Y83.6
ICD-10 Finland
Removal of other organ (partial) (total) as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.4
15.4
49
64
C09CA01
ATC
losartan; oral
1.3
15.3
1069
5721
S18
ICPC
Laceration/cut
1.2
15.2
2536
15147
O99.80
ICD-10 Finland
The fear of childbirth
0.6
15.1
337
3601
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
0.7
14.9
359
3776
A02BC05
ATC
esomeprazole; systemic
1.2
14.7
3319
20408
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.4
14.6
886
4630
N84.1
ICD-10 Finland
Polyp of cervix uteri
1.8
14.6
264
1040
N70.1
ICD-10 Finland
Chronic salpingitis and oophoritis
2.2
14.5
157
509
M01AE02
ATC
naproxen; oral, rectal
1.2
14.4
5500
35389
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
0.7
14.4
409
4165
C07AB07
ATC
bisoprolol; oral
1.2
14.4
2410
14387
O80.8
ICD-10 Finland
Other single spontaneous delivery
0.6
14.1
256
2857
N97.8
ICD-10 Finland
Female infertility of other origin
1.7
13.9
274
1111
N95.0
ICD-10 Finland
Postmenopausal bleeding
1.5
13.8
480
2256
WX110
NOMESCO Finland
Local anesthesy
1.2
13.8
6645
43519
WX702
NOMESCO Finland
Supraglottic ventilation device
1.6
13.7
419
1914
ZXK00
NOMESCO Finland
Conversion from percutaneous endoscopic to open procedure
4.1
13.6
55
94
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.4
13.5
630
3144
8113
FHL
Fractional scraping
2.1
13.3
164
562
W14
ICPC
Contraception female other
0.6
13.1
211
2418
WX400
NOMESCO Finland
Inhalation anesthesy
1.5
13.0
401
1834
N92.5
ICD-10 Finland
Other specified irregular menstruation
1.5
12.9
409
1884
205
Kela drug reimbursment
Chronic hypertension
1.3
12.8
856
4544
O63.1
ICD-10 Finland
Prolonged second stage (of labour)
0.6
12.7
208
2375
SPAT1357
SPAT
Monitoring of problem during pregnancy
0.5
12.6
133
1695
N80.4
ICD-10 Finland
Endometriosis of rectovaginal septum and vagina
1.9
12.5
199
753
C54.21
ICD-10 Finland
Leiomyosarcoma and myometrium
39.6
12.4
17
*
R93.5
ICD-10 Finland
Abnormal findings on diagnostic imaging of other abdominal regions, including retroperitoneum
2.3
12.3
114
343
C09CA06
ATC
candesartan; oral
1.2
12.3
1549
8950
LAE11
NOMESCO Finland
Unilateral laparoscopic oophorectomy
2.8
12.2
80
199
SPAT1200
SPAT
Guidance for breast-feeding and breast care
0.5
12.1
89
1262
62530
ICD-8 Finland
Other diseases of uterus, Endometriosis ovarii
10.3
12.1
25
17
G03DA02
ATC
medroxyprogesterone; systemic (pregnen (4) derivatives)
1.5
12.1
480
2324
C10AA07
ATC
rosuvastatin; oral
1.3
12.1
807
4286
Z32.1
ICD-10 Finland
Pregnancy confirmed
0.8
12.0
883
7788
SPAT1192
SPAT
Gynaecological examination
0.8
11.8
845
7479
D50.8
ICD-10 Finland
Other iron deficiency anaemias
2.2
11.8
118
369
N85.0
ICD-10 Finland
Endometrial glandular hyperplasia
1.9
11.6
168
614
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
0.8
11.6
1004
8688
A02BC03
ATC
lansoprazole; oral
1.2
11.6
2088
12518
LEE00
NOMESCO Finland
Suture of vagina
4.9
11.5
39
56
LAC00
NOMESCO Finland
Excision of ovarian cyst
3.2
11.5
61
132
LAC21
NOMESCO Finland
Laparoscopic destruction of lesion of ovary
2.0
11.3
151
537
W85
ICPC
Gestational diabetes
0.6
11.2
182
2080
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.4
11.0
463
2266
N97.9
ICD-10 Finland
Female infertility, unspecified
1.3
11.0
898
4909
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
1.8
11.0
189
735
G03DC02
ATC
norethisterone; oral
1.3
10.9
771
4129
M01AB05
ATC
diclofenac; systemic, rectal
1.2
10.9
6336
41675
H01CA02
ATC
nafarelin; nasal
1.4
10.8
451
2205
LGA21
NOMESCO Finland
Laparoscopic sterilisation by constriction of Fallopian tubes
1.3
10.7
815
4409
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.3
10.6
826
4488
W84
ICPC
Pregnancy high risk
0.6
10.5
150
1767
G03DA04
ATC
progesterone; systemic, rectal, vaginal
1.4
10.5
513
2584
J01DB01
ATC
cefalexin; oral
1.2
10.5
7942
53195
XLA10
NOMESCO Finland
NA
1.4
10.4
651
3419
M03BX02
ATC
tizanidine; oral
1.1
10.2
6372
42012
M01AE03
ATC
ketoprofen; systemic, rectal
1.2
10.2
2934
18284
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
1.3
10.2
708
3780
C10AA05
ATC
atorvastatin; oral
1.3
10.2
1092
6184
JN4BD
NOMESCO Finland
Extensive body CT
1.4
10.2
417
2033
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.3
10.2
751
4048
62620
ICD-8 Finland
Disorders of menstruation, Excessive
4.1
10.1
40
68
Z3231
NOMESCO Finland
Registered nurse
1.2
10.1
1881
11294
62660
ICD-8 Finland
Disorders of menstruation, Intermenstrual bleeding
2.8
10.1
67
170
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
1.7
10.1
209
865
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.5
10.0
373
1783
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.2
10.0
1788
10695
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
2.5
10.0
82
233
D39.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Female genital organ, unspecified
3.9
10.0
42
76
N920, D250
ICD-10 Finland
NA
+∞
9.9
11
*
N921, D259
ICD-10 Finland
NA
+∞
9.9
11
*
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
0.6
9.8
127
1532
SPAT1189
SPAT
Other ultrasound examination during pregnancy
0.6
9.8
124
1502
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.7
9.6
298
2985
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
1.6
9.6
253
1118
D26.1
ICD-10 Finland
Other benign neoplasm: Corpus uteri
6.3
9.5
26
29
JN3AD
NOMESCO Finland
Abdominal CT examination
1.4
9.5
389
1896
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
0.7
9.5
218
2312
62699
ICD-8 Finland
Disorders of menstruation, Other
2.6
9.4
70
191
N83.1
ICD-10 Finland
Corpus luteum cyst
1.7
9.3
200
835
D64.9
ICD-10 Finland
Anaemia, unspecified
1.4
9.3
395
1941
Z30.0
ICD-10 Finland
General counselling and advice on contraception
0.7
9.3
504
4627
WX002
NOMESCO Finland
Sedation and analgesia
1.2
9.2
1059
6050
N97.1
ICD-10 Finland
Female infertility of tubal origin
1.8
9.1
166
661
M03BC51
ATC
orphenadrine, combinations; systemic
1.2
9.1
2702
16854
JN2DM
NOMESCO Finland
Lower part of abdomen very extensive MRI examination with Tesla magnet
4.4
9.1
33
52
G47.3
ICD-10 Finland
Sleep apnoea
1.2
9.1
1146
6609
C09DA06
ATC
candesartan and diuretics; oral
1.5
9.0
289
1339
62551
ICD-8 Finland
NA
76.9
8.9
11
*
ZXC96
NOMESCO Finland
Robot assisted procedure
2.4
8.9
78
231
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
1.4
8.8
416
2086
R07.4
ICD-10 Finland
Chest pain, unspecified
1.2
8.8
1367
8058
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
2.0
8.8
111
390
R42
ICD-10 Finland
Dizziness and giddiness
1.2
8.7
1327
7806
N80.5
ICD-10 Finland
Endometriosis of intestine
2.2
8.7
87
274
C09DA01
ATC
losartan and diuretics; oral
1.4
8.7
374
1845
N97.2
ICD-10 Finland
Female infertility of uterine origin
4.2
8.6
33
55
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
0.6
8.6
127
1481
LCA16
NOMESCO Finland
Destruction of endometrium
1.6
8.5
238
1070
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
0.8
8.4
623
5497
WX720
NOMESCO Finland
Own respiration
1.6
8.4
219
967
D26.9
ICD-10 Finland
Other benign neoplasm: Uterus, unspecified
8.3
8.4
19
16
UKC02
NOMESCO Finland
Cystoscopy
1.3
8.4
531
2797
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
8.4
2304
14273
61610
ICD-8 Finland
Diseases of parametrium and pelvic peritoneum (female), Pelvic peritoneal adhesions, female
5.8
8.4
24
29
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.1
8.3
3872
24891
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
1.6
8.3
198
854
KCH01
NOMESCO Finland
Percutaneous endoscopic suture of bladder
11.2
8.3
16
10
Z36.4
ICD-10 Finland
Antenatal screening for fetal growth retardation using ultrasound and other physical methods
0.6
8.2
99
1214
TPH07
NOMESCO Finland
Cathetrisation of artery
1.4
8.2
386
1936
N926, D259
ICD-10 Finland
NA
+∞
8.1
9
*
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
0.7
8.1
202
2103
C08CA13
ATC
lercanidipine; oral
1.4
8.0
423
2164
A06AC01
ATC
ispaghula (psylla seeds); oral
1.2
8.0
1565
9421
ZXA00
NOMESCO Finland
Right side
1.2
8.0
1487
8914
L02AE02
ATC
leuprorelin; implant, parenteral
1.5
8.0
237
1083
C54.22
ICD-10 Finland
Endometrial stromal cell sarcoma
14.0
7.9
14
7
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
0.7
7.9
296
2873
N94.6
ICD-10 Finland
Dysmenorrhoea, unspecified
1.6
7.9
204
900
WX320
NOMESCO Finland
Spinalanesthesy
1.2
7.9
1417
8466
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
7.9
1755
10681
M03BC01
ATC
orphenadrine (citrate); systemic
1.2
7.9
2384
14869
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
1.8
7.8
140
557
J01AA02
ATC
doxycycline; systemic
1.1
7.7
7540
50669
D27.91
ICD-10 Finland
Benign epithelial tumor of the ovary (ovary)
2.0
7.7
94
327
Y60.0
ICD-10 Finland
Unintentional cut, puncture, perforation or haemorrhage during surgical and medical care during surgical operation
3.4
7.6
37
77
8811
FHL
Cesarean section
1.3
7.6
613
3349
N02AJ06
ATC
codeine and paracetamol; systemic
1.1
7.6
2979
18916
O64.0
ICD-10 Finland
Obstructed labour due to incomplete rotation of fetal head
0.6
7.5
131
1468
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
1.4
7.5
311
1524
N03AX16
ATC
pregabalin; oral
1.2
7.5
1638
9952
SPAT1316
SPAT
Extensive health check-up of children and adolescents
0.6
7.5
164
1751
8308
FHL
Hysterectomy and bilateral adnexal removal
4.0
7.5
30
53
XLD10
NOMESCO Finland
Gynaecological examination
2.6
7.4
52
139
1413
FHL
Laparoscopy and other therapeutic procedure
1.6
7.4
198
883
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.3
7.4
442
2314
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.1
7.3
2522
15860
N92
ICD-10 Finland
Excessive, frequent and irregular menstruation
1.6
7.3
182
797
N920, D251
ICD-10 Finland
NA
+∞
7.2
8
*
M01AC06
ATC
meloxicam; systemic, rectal
1.1
7.2
2805
17784
M01AH01
ATC
celecoxib; oral (coxibs)
1.2
7.1
1132
6684
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.3
7.1
753
4260
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
0.7
7.1
297
2826
N80.81
ICD-10 Finland
Endometriosis in sacrouteral ligament
2.3
7.1
61
182
Z54.0
ICD-10 Finland
Convalescence following surgery
1.8
7.0
127
507
XF402
NOMESCO Finland
ECG with work load test
1.4
7.0
325
1629
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.3
7.0
431
2264
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
2.4
7.0
58
170
M79.6
ICD-10 Finland
Pain in limb
1.1
7.0
2889
18387
KBV12
NOMESCO Finland
Transluminal endoscopic removal of stent from ureter
2.2
7.0
71
230
SPAT1195
SPAT
Antenatal classes
0.6
6.9
109
1250
D06
ICPC
Abdominal pain localized other
1.3
6.9
550
2999
N03AX12
ATC
gabapentin; oral
1.2
6.9
1043
6130
O75.6
ICD-10 Finland
Delayed delivery after spontaneous or unspecified rupture of membranes
0.5
6.9
43
635
M01AX05
ATC
glucosamine; oral
1.3
6.9
533
2900
JAL20
NOMESCO Finland
Excision or destruction of lesion of peritoneum
2.4
6.8
59
175
MAC96
NOMESCO Finland
Other induction or advancement of labour
0.7
6.8
193
1959
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.2
6.8
1507
9166
ZXA05
NOMESCO Finland
Left side
1.2
6.7
1367
8254
G03GA06
ATC
follitropin beta; parenteral
1.3
6.7
454
2424
J01MA02
ATC
ciprofloxacin; systemic
1.1
6.6
2637
16727
JN4AD
NOMESCO Finland
Body CT examination
1.5
6.6
243
1165
G03GA01
ATC
chorionic gonadotrophin; parenteral
1.3
6.6
654
3670
SPAT1315
SPAT
Periodic health check-up of children and adolescents
0.6
6.6
109
1233
R33
ICD-10 Finland
Retention of urine
1.6
6.6
171
756
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
0.6
6.6
82
995
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
0.5
6.6
64
828
N05CF02
ATC
zolpidem; oral
1.2
6.6
1488
9066
L02AE03
ATC
goserelin; implant
1.7
6.6
135
563
O75.0
ICD-10 Finland
Maternal distress during labour and delivery
0.5
6.5
57
760
22099
ICD-8 Finland
Benign neoplasm of ovary, Other and unspecified
2.6
6.4
45
120
X80
ICPC
Benign neoplasm female genital
6.3
6.4
17
19
1410
FHL
Laparoscopy
1.5
6.4
210
983
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
1.7
6.4
123
501
N39.3
ICD-10 Finland
Stress incontinence
1.3
6.4
576
3197
Z30.8
ICD-10 Finland
Other contraceptive management
0.6
6.4
92
1074
N05AH02
ATC
clozapine; systemic
0.5
6.4
47
660
KH1AD
NOMESCO Finland
CT of urinary organs
1.6
6.3
157
687
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
2.2
6.3
61
192
R103, D259
ICD-10 Finland
NA
+∞
6.3
7
*
Z30
ICD-10 Finland
Contraceptive management
0.6
6.2
109
1216
TLC00
SPAT
NA
0.4
6.2
31
496
L15
ICPC
Knee symptom/complaint
1.2
6.2
1134
6784
KC1GB
NOMESCO Finland
Cystography with X-ray
4.8
6.2
20
29
W29
ICPC
Pregnancy symptom/complaint other
0.6
6.1
101
1140
61520
ICD-8 Finland
Other diseases of ovary and Fallopian tube, Cysta (cystis) follicularis ovarii (retentio)
3.1
6.1
32
72
L02AE01
ATC
buserelin; implant, nasal, parenteral
1.5
6.1
197
920
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
0.9
6.1
1419
11242
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.2
6.1
760
4382
K66.0
ICD-10 Finland
Peritoneal adhesions
2.4
6.0
49
143
KBH20
NOMESCO Finland
Replantation of ureter
4.7
6.0
20
30
N94.4
ICD-10 Finland
Primary dysmenorrhoea
1.6
6.0
154
683
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_LEIOMYOMA_UTERI and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_LEIOMYOMA_UTERI | 0.867 [0.8, 0.94] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 9080 out of 138246 females with CD2_BENIGN_LEIOMYOMA_UTERI died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_LEIOMYOMA_UTERI.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.076% | No data |
| 5 | 0.498% | No data |
| 10 | 1.288% | No data |
| 15 | 2.456% | No data |
| 20 | 4.441% | No data |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_LEIOMYOMA_UTERI – Leiomyoma of uterus
GWS hits: 141
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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