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Nontoxic single thyroid nodule

DOID EFO Endpoint Browser PheWeb

E4_GOITRENOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E04.1
  • Hospital discharge: ICD-9 — 2410|2462
  • Cause of death: ICD-10 — E04.1
  • Cause of death: ICD-9 — 2410|2462

2 out of 7 registries used, show all original rules.

2866

4. Check minimum number of events

None

2866

5. Include endpoints

None

2866

6. Filter based on genotype QC (FinnGen only)

2866

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E04
Name in latin
Struma atoxica uninodularis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17821 14391 3351
Only index persons 16839 13735 3104
Unadjusted period prevalence (%)
Whole population 0.35 0.41 0.09
Only index persons 0.43 0.50 0.12
Median age at first event (years)
Whole population 51.50 50.54 55.53
Only index persons 50.93 50.05 54.82

-FinnGen-

Key figures

All Female Male
Number of individuals 2866 2312 554
Unadjusted period prevalence (%) 0.68 0.79 0.24
Median age at first event (years) 51.34 49.48 59.10

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2583
Matched controls
25830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
360.7
323.0
816
33
H03AA01
ATC
levothyroxine sodium; systemic
66.9
323.0
1098
282
104
Kela drug reimbursment
Thyroid insufficiency
365.0
323.0
399
13
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
223.0
323.0
639
38
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
106.5
323.0
427
48
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
9098.8
323.0
2220
16
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
309.7
291
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
69.8
306.2
351
58
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
63.3
280.8
327
59
2504
FHL
Unilateral resection or enucleation
159.8
235.2
246
17
EP1AE
NOMESCO Finland
Neck ultrasound examination
10.8
219.3
449
494
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
197.5
187
*
BAA60
NOMESCO Finland
Total thyroidectomy
411.3
193.6
192
5
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
42.1
189.5
238
62
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
56.3
182.6
217
42
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
406.1
155.0
154
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
164.7
148.2
155
10
E03
ICD-10 Finland
Other hypothyroidism
63.0
146.6
171
29
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
457.0
132.3
131
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
115.9
122.3
132
12
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
51.8
122.0
147
30
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
213.2
118.7
122
6
T86
ICPC
Hypothyroidism/myxoedema
36.7
97.7
126
36
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
127.2
91.6
98
8
2462A
ICD-9 Finland
Other disorders of thyroid, Cyst of thyroid
+∞
83.8
80
*
H03BB01
ATC
carbimazole; oral
55.3
80.8
96
18
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
198.3
74.6
77
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
137.5
63.2
67
5
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
622.6
62.0
61
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
57.5
55
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
5.3
56.3
182
367
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
50.2
48
*
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
49.1
47
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
9.9
48.1
99
104
E04.8
ICD-10 Finland
Other specified nontoxic goitre
106.7
38.8
42
*
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
101.6
36.8
40
*
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
+∞
35.5
34
*
E04
ICD-10 Finland
Other nontoxic goitre
47.4
34.7
42
9
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
33.4
571
3331
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
75.2
32.9
37
5
BAA30
NOMESCO Finland
Excision of thyroid isthmus
+∞
31.3
30
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
31.3
30
*
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
316.5
30.9
31
*
QX3LT
NOMESCO Finland
Subcutaneous sclerotherapy
68.8
29.9
34
5
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
29.2
28
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
53.9
27.2
32
6
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.0
27.0
167
590
106
Kela drug reimbursment
Hypoparathyroidism
52.2
26.2
31
6
A02BC05
ATC
esomeprazole; systemic
1.6
26.1
1043
7731
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
+∞
25.0
24
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
24.0
23
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
24.0
23
*
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
12.5
23.6
42
34
N02BE01
ATC
paracetamol; systemic, rectal
1.7
23.4
2186
19670
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
45.4
22.4
27
6
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
221.8
21.6
22
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
221.8
21.6
22
*
R13
ICD-10 Finland
Dysphagia
2.5
21.6
170
696
E06.3
ICD-10 Finland
Autoimmune thyroiditis
28.3
20.9
28
10
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
77.4
20.7
23
*
T81
ICPC
Goitre
18.4
20.4
31
17
E06.9
ICD-10 Finland
Thyroiditis, unspecified
74.1
19.7
22
*
2506
FHL
Thyroidectomy
201.4
19.6
20
*
BA1AE
SPAT
NA
8.6
18.2
39
46
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
17.7
17
*
E07.89
ICD-10 Finland
Other specified disorders of thyroid
37.0
17.6
22
6
4CJ01
NOMESCO Finland
NA
181.2
17.5
18
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
17.5
626
4420
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
29.0
17.4
23
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
16.7
843
6407
1930A
ICD-9 Finland
Malignant neoplasm of thyroid gland[CARCINOMA PAPILLARE THYREOIDEAE]
+∞
16.7
16
*
T71
ICPC
Malignant neoplasm thyroid
+∞
16.7
16
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
16.2
529
3644
T72
ICPC
Benign neoplasm thyroid
21.1
16.0
23
11
R49.08
ICD-10 Finland
Other specified dysphonia
3.7
15.9
69
189
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
+∞
15.6
15
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
15.0
658
4838
R49.01
ICD-10 Finland
Functional dysphonia
2.9
14.7
90
318
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
14.0
87
312
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
14.0
524
3714
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
13.9
245
1411
J01FA10
ATC
azithromycin; systemic
1.4
13.9
1398
11925
A02BC02
ATC
pantoprazole; systemic
1.4
13.7
1550
13467
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
13.5
13
*
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
+∞
13.5
13
*
A11CC02
ATC
dihydrotachysterol; oral
34.2
13.5
17
5
BAA99
NOMESCO Finland
Other operation on thyroid gland
140.7
13.5
14
*
EP1AE
SPAT
NA
4.3
13.4
49
116
R01AD09
ATC
mometasone; nasal
1.4
13.0
1066
8750
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
12.8
801
6266
BA2AT
NOMESCO Finland
Biopsy of thyroid with ultrasound quidance
32.2
12.6
16
5
M54.5
ICD-10 Finland
Low back pain
1.4
12.5
752
5834
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
12.5
12
*
M01AE02
ATC
naproxen; oral, rectal
1.4
12.4
1344
11503
J37.0
ICD-10 Finland
Chronic laryngitis
2.6
12.1
87
340
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
11.8
378
2575
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
16.5
11.7
18
11
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.8
11.5
220
1302
R03AC02
ATC
salbutamol; inhalant
1.3
11.5
1234
10499
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
11.5
11
*
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
11.5
11
*
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
120.5
11.4
12
*
SPAT1263
SPAT
Sampling
1.3
11.3
971
7976
ZXA05
NOMESCO Finland
Left side
1.4
11.3
567
4245
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
11.1
531
3935
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
3.5
11.1
51
149
ZXA00
NOMESCO Finland
Right side
1.4
11.0
607
4625
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
10.9
230
1402
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
43.5
10.9
13
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
10.9
557
4180
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
3.9
10.8
43
112
R51.80
ICD-10 Finland
Headache
1.6
10.7
329
2216
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
10.6
1150
9752
R01AD08
ATC
fluticasone; nasal
1.4
10.5
657
5107
S04
ICPC
Lump/swelling localized
1.7
10.5
201
1190
GB1AA
NOMESCO Finland
Tracheal X-ray examination
110.4
10.4
11
*
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
+∞
10.4
10
*
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
+∞
10.4
10
*
M25.5
ICD-10 Finland
Pain in joint
1.4
10.4
653
5083
A11CC03
ATC
alfacalcidol; systemic
3.2
10.3
52
164
J01DB01
ATC
cefalexin; oral
1.4
10.2
1949
17912
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
10.2
276
1803
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
10.1
915
7538
J01FA09
ATC
clarithromycin; systemic
1.4
10.0
736
5871
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
7.4
9.7
22
30
A02BC01
ATC
omeprazole; systemic
1.4
9.6
604
4691
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
9.6
808
6574
ZX114
NOMESCO Finland
Intramuscular
3.6
9.5
41
115
Z50.5
ICD-10 Finland
Speech therapy
3.9
9.5
37
95
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
9.4
377
2687
T15
ICPC
THYROID LUMP/MASS
30.1
9.4
12
*
T85
ICPC
Hyperthyroidism/thyrotoxicosis
17.6
9.4
14
8
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
9.4
9
*
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
+∞
9.4
9
*
C07AA05
ATC
propranolol; systemic
1.4
9.4
424
3104
J01AA02
ATC
doxycycline; systemic
1.3
9.2
1905
17528
G47.3
ICD-10 Finland
Sleep apnoea
1.5
9.1
384
2769
A02BC04
ATC
rabeprazole; oral
1.7
9.1
195
1197
R00.2
ICD-10 Finland
Palpitations
1.8
9.0
160
930
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
8.6
681
5471
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
8.6
1254
10952
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
3.9
8.6
34
89
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
12.8
8.4
14
11
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
8.3
559
4375
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
8.3
8
*
A12AA04
ATC
calcium carbonate; oral
3.6
8.3
35
97
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
8.2
930
7846
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.1
8.2
93
461
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
1.9
8.1
121
663
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
3.8
8.1
32
84
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
1.6
8.1
231
1531
A02BA02
ATC
ranitidine; systemic
1.4
8.1
418
3133
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
8.0
1622
14710
C07AB07
ATC
bisoprolol; oral
1.3
8.0
960
8157
R07.0
ICD-10 Finland
Pain in throat
1.8
8.0
129
726
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.8
8.0
145
847
XKD00
NOMESCO Finland
Uroflowmetry
1.6
7.9
214
1399
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
7.9
889
7484
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.8
7.9
130
737
J01DA01
ATC
[U] cefalexin; systemic
1.3
7.9
1451
12993
SPAT1312
SPAT
General health counselling
1.3
7.9
710
5800
R42
ICD-10 Finland
Dizziness and giddiness
1.4
7.8
463
3545
R01AD12
ATC
fluticasone furoate; nasal
1.3
7.6
643
5200
A77
ICPC
Viral disease other/NOS
2.2
7.6
76
357
E83.51
ICD-10 Finland
Hypocalcemia
6.7
7.6
18
27
SPAT1211
SPAT
Application of soft bandage
1.6
7.5
187
1196
UKC02
NOMESCO Finland
Cystoscopy
1.5
7.5
265
1841
UJF32
NOMESCO Finland
Coloscopy
1.3
7.4
542
4290
C739
ICD-10 Finland
NA
80.3
7.4
8
*
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
80.3
7.4
8
*
Z00.0
ICD-10 Finland
General medical examination
1.4
7.4
387
2897
Z01.2
ICD-10 Finland
Dental examination
1.3
7.4
924
7864
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
7.4
216
1438
M01AB05
ATC
diclofenac; systemic, rectal
1.3
7.4
1552
14065
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.4
7.3
450
3468
L01
ICPC
Neck symptom/complaint
1.4
7.3
300
2150
R52.9
ICD-10 Finland
Pain, unspecified
1.6
7.3
172
1083
N03AX16
ATC
pregabalin; oral
1.3
7.3
510
4010
2502
FHL
Thyroid exploration and possible biopsy
+∞
7.3
7
*
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
7.3
7
*
C05AA08
ATC
fluocortolone; rectal, topical
1.4
7.3
305
2197
M01AH05
ATC
etoricoxib; oral
1.3
7.2
1362
12174
SPAT1153
SPAT
Removal of sutures
1.3
7.2
692
5693
R12
ICD-10 Finland
Heartburn
1.7
7.1
151
923
A12AA06
ATC
calcium lactate gluconate; oral
30.1
7.1
9
*
BA3AT
SPAT
NA
30.1
7.1
9
*
K07.60
ICD-10 Finland
Snapping jaw
1.8
7.1
111
620
R03BA05
ATC
fluticasone; inhalant
1.4
7.1
390
2949
J01FA06
ATC
roxithromycin; oral
1.3
7.0
910
7774
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
7.0
277
1967
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
4.1
7.0
25
61
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
7.0
734
6108
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
3.3
7.0
33
102
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
6.9
1227
10860
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.2
6.8
64
294
J02AC01
ATC
fluconazole; systemic
1.3
6.8
1013
8784
M01AC06
ATC
meloxicam; systemic, rectal
1.3
6.8
833
7059
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
6.8
814
6879
K30
ICD-10 Finland
Functional dyspepsia
1.5
6.7
229
1580
E06
ICD-10 Finland
Thyroiditis
22.6
6.7
9
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.5
6.6
194
1295
N40
ICD-10 Finland
Hyperplasia of prostate
1.5
6.5
218
1499
62630
ICD-8 Finland
Disorders of menstruation, Painful
3.5
6.5
28
81
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.5
627
5150
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.6
6.4
163
1050
A98
ICPC
Health maint/preventive medicine
1.5
6.3
2441
23705
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
6.3
854
7306
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.5
6.3
238
1675
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
6.3
391
3013
R05FB02
ATC
cough suppressants and expectorants
1.3
6.3
853
7304
R21
ICPC
Throat symptom/complaint
1.4
6.3
389
2995
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
6.3
233
1637
8290/3-C73.9
ICD-O-3
Oxyphilic adenocarcinoma of thyroid gland
+∞
6.3
6
*
R06.0
ICD-10 Finland
Dyspnoea
1.3
6.2
492
3929
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
6.2
1049
9203
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
2.4
6.2
47
194
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
6.3
6.2
15
24
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.4
6.1
244
1737
L03
ICPC
Low back symptom/complaint
1.3
6.1
512
4120
G44.2
ICD-10 Finland
Tension-type headache
1.4
6.1
289
2126
XA402
NOMESCO Finland
ENMG
2.2
6.1
59
277
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
6.1
170
1123
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.6
6.1
150
961

Mortality – FinRegistry

↥

Association

Association between endpoint E4_GOITRENOD and mortality.

Females

Parameter HR [95% CI] p-value
E4_GOITRENOD 0.933 [0.84, 1.03] 0.168
Birth year 0.994 [0.99, 1.0] 0.161

During the follow-up period (1.1.1998 — 31.12.2019), 978 out of 10026 females with E4_GOITRENOD died.

Males

Parameter HR [95% CI] p-value
E4_GOITRENOD 0.863 [0.76, 0.98] 0.019
Birth year 0.993 [0.98, 1.0] 0.145

During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 2426 males with E4_GOITRENOD died.

Mortality risk

Mortality risk for people of age

years, who have E4_GOITRENOD.

N-year risk Females Males
1 0.064% 0.205%
5 0.56% 1.157%
10 1.27% 3.068%
15 2.514% 5.741%
20 4.303% 10.132%

Relationships between endpoints

↥

Index endpoint: E4_GOITRENOD – Nontoxic single thyroid nodule

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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