nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2866 |
4. Check minimum number of eventsNone |
2866 |
5. Include endpointsNone |
2866 |
6. Filter based on genotype QC (FinnGen only) |
2866 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E04
- Name in latin
- Struma atoxica uninodularis
Similar endpoints
↥List of similar endpoints to
Nontoxic single thyroid nodule
based on the number of shared cases.
Similar with more cases:
- Nontoxic goitre/thyroid nodule
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17821 | 14391 | 3351 |
| Only index persons | 16839 | 13735 | 3104 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.35 | 0.41 | 0.09 |
| Only index persons | 0.43 | 0.50 | 0.12 |
| Median age at first event (years) | |||
| Whole population | 51.50 | 50.54 | 55.53 |
| Only index persons | 50.93 | 50.05 | 54.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2866 | 2312 | 554 |
| Unadjusted period prevalence (%) | 0.68 | 0.79 | 0.24 |
| Median age at first event (years) | 51.34 | 49.48 | 59.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2583
- Matched controls
- 25830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
106.5
323.0
427
48
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
223.0
323.0
639
38
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
9098.8
323.0
2220
16
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
360.7
323.0
816
33
H03AA01
ATC
levothyroxine sodium; systemic
66.9
323.0
1098
282
104
Kela drug reimbursment
Thyroid insufficiency
365.0
323.0
399
13
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
309.7
291
*
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
69.8
306.2
351
58
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
63.3
280.8
327
59
2504
FHL
Unilateral resection or enucleation
159.8
235.2
246
17
EP1AE
NOMESCO Finland
Neck ultrasound examination
10.8
219.3
449
494
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
+∞
197.5
187
*
BAA60
NOMESCO Finland
Total thyroidectomy
411.3
193.6
192
5
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
42.1
189.5
238
62
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
56.3
182.6
217
42
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
406.1
155.0
154
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
164.7
148.2
155
10
E03
ICD-10 Finland
Other hypothyroidism
63.0
146.6
171
29
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
457.0
132.3
131
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
115.9
122.3
132
12
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
51.8
122.0
147
30
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
213.2
118.7
122
6
T86
ICPC
Hypothyroidism/myxoedema
36.7
97.7
126
36
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
127.2
91.6
98
8
2462A
ICD-9 Finland
Other disorders of thyroid, Cyst of thyroid
+∞
83.8
80
*
H03BB01
ATC
carbimazole; oral
55.3
80.8
96
18
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
198.3
74.6
77
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
137.5
63.2
67
5
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
622.6
62.0
61
*
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
+∞
57.5
55
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
5.3
56.3
182
367
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
+∞
50.2
48
*
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
+∞
49.1
47
*
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
9.9
48.1
99
104
E04.8
ICD-10 Finland
Other specified nontoxic goitre
106.7
38.8
42
*
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
101.6
36.8
40
*
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
+∞
35.5
34
*
E04
ICD-10 Finland
Other nontoxic goitre
47.4
34.7
42
9
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
33.4
571
3331
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
75.2
32.9
37
5
BAA30
NOMESCO Finland
Excision of thyroid isthmus
+∞
31.3
30
*
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
31.3
30
*
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
316.5
30.9
31
*
QX3LT
NOMESCO Finland
Subcutaneous sclerotherapy
68.8
29.9
34
5
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
29.2
28
*
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
53.9
27.2
32
6
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.0
27.0
167
590
106
Kela drug reimbursment
Hypoparathyroidism
52.2
26.2
31
6
A02BC05
ATC
esomeprazole; systemic
1.6
26.1
1043
7731
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
+∞
25.0
24
*
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
24.0
23
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
24.0
23
*
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
12.5
23.6
42
34
N02BE01
ATC
paracetamol; systemic, rectal
1.7
23.4
2186
19670
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
45.4
22.4
27
6
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
221.8
21.6
22
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
221.8
21.6
22
*
R13
ICD-10 Finland
Dysphagia
2.5
21.6
170
696
E06.3
ICD-10 Finland
Autoimmune thyroiditis
28.3
20.9
28
10
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
77.4
20.7
23
*
T81
ICPC
Goitre
18.4
20.4
31
17
E06.9
ICD-10 Finland
Thyroiditis, unspecified
74.1
19.7
22
*
2506
FHL
Thyroidectomy
201.4
19.6
20
*
BA1AE
SPAT
NA
8.6
18.2
39
46
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
17.7
17
*
E07.89
ICD-10 Finland
Other specified disorders of thyroid
37.0
17.6
22
6
4CJ01
NOMESCO Finland
NA
181.2
17.5
18
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
17.5
626
4420
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
29.0
17.4
23
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
16.7
843
6407
1930A
ICD-9 Finland
Malignant neoplasm of thyroid gland[CARCINOMA PAPILLARE THYREOIDEAE]
+∞
16.7
16
*
T71
ICPC
Malignant neoplasm thyroid
+∞
16.7
16
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
16.2
529
3644
T72
ICPC
Benign neoplasm thyroid
21.1
16.0
23
11
R49.08
ICD-10 Finland
Other specified dysphonia
3.7
15.9
69
189
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
+∞
15.6
15
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
15.0
658
4838
R49.01
ICD-10 Finland
Functional dysphonia
2.9
14.7
90
318
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.8
14.0
87
312
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
14.0
524
3714
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.8
13.9
245
1411
J01FA10
ATC
azithromycin; systemic
1.4
13.9
1398
11925
A02BC02
ATC
pantoprazole; systemic
1.4
13.7
1550
13467
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
13.5
13
*
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
+∞
13.5
13
*
A11CC02
ATC
dihydrotachysterol; oral
34.2
13.5
17
5
BAA99
NOMESCO Finland
Other operation on thyroid gland
140.7
13.5
14
*
EP1AE
SPAT
NA
4.3
13.4
49
116
R01AD09
ATC
mometasone; nasal
1.4
13.0
1066
8750
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
12.8
801
6266
BA2AT
NOMESCO Finland
Biopsy of thyroid with ultrasound quidance
32.2
12.6
16
5
M54.5
ICD-10 Finland
Low back pain
1.4
12.5
752
5834
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
12.5
12
*
M01AE02
ATC
naproxen; oral, rectal
1.4
12.4
1344
11503
J37.0
ICD-10 Finland
Chronic laryngitis
2.6
12.1
87
340
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
11.8
378
2575
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
16.5
11.7
18
11
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.8
11.5
220
1302
R03AC02
ATC
salbutamol; inhalant
1.3
11.5
1234
10499
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
11.5
11
*
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
11.5
11
*
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
120.5
11.4
12
*
SPAT1263
SPAT
Sampling
1.3
11.3
971
7976
ZXA05
NOMESCO Finland
Left side
1.4
11.3
567
4245
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
11.1
531
3935
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
3.5
11.1
51
149
ZXA00
NOMESCO Finland
Right side
1.4
11.0
607
4625
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
10.9
230
1402
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
43.5
10.9
13
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
10.9
557
4180
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
3.9
10.8
43
112
R51.80
ICD-10 Finland
Headache
1.6
10.7
329
2216
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
10.6
1150
9752
R01AD08
ATC
fluticasone; nasal
1.4
10.5
657
5107
S04
ICPC
Lump/swelling localized
1.7
10.5
201
1190
GB1AA
NOMESCO Finland
Tracheal X-ray examination
110.4
10.4
11
*
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
+∞
10.4
10
*
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
+∞
10.4
10
*
M25.5
ICD-10 Finland
Pain in joint
1.4
10.4
653
5083
A11CC03
ATC
alfacalcidol; systemic
3.2
10.3
52
164
J01DB01
ATC
cefalexin; oral
1.4
10.2
1949
17912
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.6
10.2
276
1803
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
10.1
915
7538
J01FA09
ATC
clarithromycin; systemic
1.4
10.0
736
5871
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
7.4
9.7
22
30
A02BC01
ATC
omeprazole; systemic
1.4
9.6
604
4691
ZX114
NOMESCO Finland
Intramuscular
3.6
9.5
41
115
Z50.5
ICD-10 Finland
Speech therapy
3.9
9.5
37
95
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
9.4
377
2687
T15
ICPC
THYROID LUMP/MASS
30.1
9.4
12
*
T85
ICPC
Hyperthyroidism/thyrotoxicosis
17.6
9.4
14
8
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
9.4
9
*
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
+∞
9.4
9
*
C07AA05
ATC
propranolol; systemic
1.4
9.4
424
3104
J01AA02
ATC
doxycycline; systemic
1.3
9.2
1905
17528
G47.3
ICD-10 Finland
Sleep apnoea
1.5
9.1
384
2769
A02BC04
ATC
rabeprazole; oral
1.7
9.1
195
1197
R00.2
ICD-10 Finland
Palpitations
1.8
9.0
160
930
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
8.6
681
5471
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.3
8.6
1254
10952
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
3.9
8.6
34
89
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
12.8
8.4
14
11
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
8.3
559
4375
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
8.3
8
*
A12AA04
ATC
calcium carbonate; oral
3.6
8.3
35
97
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
8.2
930
7846
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.1
8.2
93
461
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
1.9
8.1
121
663
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
3.8
8.1
32
84
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
1.6
8.1
231
1531
A02BA02
ATC
ranitidine; systemic
1.4
8.1
418
3133
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
8.0
1622
14710
C07AB07
ATC
bisoprolol; oral
1.3
8.0
960
8157
R07.0
ICD-10 Finland
Pain in throat
1.8
8.0
129
726
XKD00
NOMESCO Finland
Uroflowmetry
1.6
7.9
214
1399
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
7.9
889
7484
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.8
7.9
130
737
J01DA01
ATC
[U] cefalexin; systemic
1.3
7.9
1451
12993
SPAT1312
SPAT
General health counselling
1.3
7.9
710
5800
R42
ICD-10 Finland
Dizziness and giddiness
1.4
7.8
463
3545
R01AD12
ATC
fluticasone furoate; nasal
1.3
7.6
643
5200
A77
ICPC
Viral disease other/NOS
2.2
7.6
76
357
E83.51
ICD-10 Finland
Hypocalcemia
6.7
7.6
18
27
SPAT1211
SPAT
Application of soft bandage
1.6
7.5
187
1196
UKC02
NOMESCO Finland
Cystoscopy
1.5
7.5
265
1841
UJF32
NOMESCO Finland
Coloscopy
1.3
7.4
542
4290
Z85.8
ICD-10 Finland
Personal history of malignant neoplasms of other organs and systems
80.3
7.4
8
*
C739
ICD-10 Finland
NA
80.3
7.4
8
*
Z00.0
ICD-10 Finland
General medical examination
1.4
7.4
387
2897
Z01.2
ICD-10 Finland
Dental examination
1.3
7.4
924
7864
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
7.4
216
1438
M01AB05
ATC
diclofenac; systemic, rectal
1.3
7.4
1552
14065
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.4
7.3
450
3468
L01
ICPC
Neck symptom/complaint
1.4
7.3
300
2150
R52.9
ICD-10 Finland
Pain, unspecified
1.6
7.3
172
1083
N03AX16
ATC
pregabalin; oral
1.3
7.3
510
4010
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
7.3
7
*
2502
FHL
Thyroid exploration and possible biopsy
+∞
7.3
7
*
C05AA08
ATC
fluocortolone; rectal, topical
1.4
7.3
305
2197
M01AH05
ATC
etoricoxib; oral
1.3
7.2
1362
12174
SPAT1153
SPAT
Removal of sutures
1.3
7.2
692
5693
R12
ICD-10 Finland
Heartburn
1.7
7.1
151
923
A12AA06
ATC
calcium lactate gluconate; oral
30.1
7.1
9
*
BA3AT
SPAT
NA
30.1
7.1
9
*
K07.60
ICD-10 Finland
Snapping jaw
1.8
7.1
111
620
R03BA05
ATC
fluticasone; inhalant
1.4
7.1
390
2949
J01FA06
ATC
roxithromycin; oral
1.3
7.0
910
7774
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
7.0
277
1967
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
4.1
7.0
25
61
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
7.0
734
6108
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
3.3
7.0
33
102
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
6.9
1227
10860
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.2
6.8
64
294
J02AC01
ATC
fluconazole; systemic
1.3
6.8
1013
8784
M01AC06
ATC
meloxicam; systemic, rectal
1.3
6.8
833
7059
SAA03
NOMESCO Finland
Extended examination of mouth
1.3
6.8
814
6879
K30
ICD-10 Finland
Functional dyspepsia
1.5
6.7
229
1580
E06
ICD-10 Finland
Thyroiditis
22.6
6.7
9
*
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.5
6.6
194
1295
N40
ICD-10 Finland
Hyperplasia of prostate
1.5
6.5
218
1499
62630
ICD-8 Finland
Disorders of menstruation, Painful
3.5
6.5
28
81
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.5
627
5150
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.6
6.4
163
1050
A98
ICPC
Health maint/preventive medicine
1.5
6.3
2441
23705
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
6.3
854
7306
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.5
6.3
238
1675
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
6.3
391
3013
R05FB02
ATC
cough suppressants and expectorants
1.3
6.3
853
7304
R21
ICPC
Throat symptom/complaint
1.4
6.3
389
2995
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
6.3
233
1637
8290/3-C73.9
ICD-O-3
Oxyphilic adenocarcinoma of thyroid gland
+∞
6.3
6
*
R06.0
ICD-10 Finland
Dyspnoea
1.3
6.2
492
3929
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
6.2
1049
9203
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
2.4
6.2
47
194
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
6.3
6.2
15
24
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.4
6.1
244
1737
L03
ICPC
Low back symptom/complaint
1.3
6.1
512
4120
G44.2
ICD-10 Finland
Tension-type headache
1.4
6.1
289
2126
XA402
NOMESCO Finland
ENMG
2.2
6.1
59
277
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
6.1
170
1123
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.6
6.1
150
961
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
445
563
9.17
307.65
1.5
1.3
—
—
—
0
0
487
797
7.16
293.34
4.0
1.7
4.6
4.5
pmol/l
1.10
441
702
181
73
26.40
260.03
6.5
1.2
174.3
261.0
u/ml
—
58
9
2562
18319
4.76
165.46
6.7
2.6
15.3
14.4
pmol/l
57.04
2409
16525
1719
11766
2.15
84.01
6.3
6.1
1.2
1.2
mmol/l
0.13
1455
9926
2670
22251
3.92
83.51
8.0
3.5
1.9
2.0
mu/l
0.36
2509
20293
366
1268
3.16
81.21
1.3
1.1
93.7
79.8
iu/ml
0.30
121
411
142
275
5.38
69.87
1.5
1.2
3.9
2.2
iu/l
0.76
33
53
1513
10627
1.90
60.15
5.3
5.5
1.2
1.2
mmol/l
0.42
1374
9578
2155
17999
1.80
38.77
4.5
4.1
11.0
12.5
mm/h
6.30
1998
16646
1381
10320
1.65
37.04
2.4
2.2
81.1
78.8
nmol/l
2.26
1231
9275
351
1725
2.18
36.66
2.9
3.5
63.6
88.1
ng/l
11.23
287
1473
513
2987
1.87
33.07
4.8
4.4
33.1
32.9
%
0.08
370
1968
2139
18640
1.58
24.21
7.6
7.4
76.2
77.5
u/l
0.75
2022
17481
1119
8602
1.49
22.64
3.7
3.4
40.0
97.7
ng/l
0.51
741
5654
1416
11449
1.47
21.97
3.7
3.9
—
—
—
0
0
2505
22897
1.75
21.38
13.7
12.4
80.0
80.8
ml/min/173m2
1.10
2188
18778
2605
24185
1.85
19.73
14.3
13.4
18.4
23.2
mg/l
12.96
2118
18935
1397
11441
1.43
19.24
5.8
6.0
28.9
28.2
%
1.79
1286
10643
326
1940
1.77
18.90
4.3
3.5
1.2
1.2
mmol/l
0.02
298
1678
1379
11304
1.42
18.68
5.5
5.8
56.6
57.2
%
1.27
1285
10547
2659
24920
1.93
18.48
15.9
14.9
139.9
139.7
mmol/l
3.76
2601
24294
1054
8265
1.44
18.09
2.9
3.4
2.3
2.4
mmol/l
4.31
903
7192
2663
24996
1.92
18.02
16.0
15.0
3.9
3.9
mmol/l
2.73
2599
24307
2545
23596
1.70
17.66
5.0
4.4
5.8
5.9
mmol/l
0.14
2312
21520
1469
12250
1.41
17.65
5.7
6.0
0.2
0.2
e9/l
0.12
1316
10715
963
7453
1.44
17.64
2.5
2.5
54.8
57.3
u/l
1.63
898
6866
1350
11102
1.41
17.54
5.6
6.0
2.9
2.8
%
0.33
1245
10330
333
2035
1.72
17.53
2.3
2.0
366.0
371.8
nmol/l
0.22
305
1864
2567
23983
1.67
15.67
4.8
4.3
4.8
4.8
mmol/l
0.39
2361
22190
2475
22922
1.58
15.63
4.3
3.8
1.3
1.3
mmol/l
0.54
2253
20938
773
5854
1.44
15.53
2.2
2.2
—
—
—
0
0
1440
12127
1.38
15.46
5.7
5.8
1.9
1.9
e9/l
0.85
1290
10640
1791
15643
1.39
15.26
3.1
3.0
41.8
44.9
u/l
1.09
1658
14519
1596
13692
1.37
15.13
3.8
4.3
6.5
6.6
mmol/l
0.79
1510
12757
2396
22089
1.52
14.83
6.0
5.4
39.2
39.3
mmol/mol
0.03
2204
20409
2713
25810
1.96
14.82
11.1
10.2
24.4
24.5
u/l
0.14
2620
24894
2549
23831
1.63
14.79
4.8
4.2
1.5
1.5
mmol/l
2.23
2335
21928
896
7036
1.40
14.46
2.0
2.1
143.6
197.8
u/l
2.41
836
6591
2597
24441
1.67
14.09
5.2
4.7
2.8
2.8
mmol/l
0.12
2374
22483
1469
12539
1.35
13.83
5.6
6.1
10.4
10.8
umol/l
0.81
1381
11892
594
4394
1.44
13.25
1.3
1.3
21.4
33.2
iu/ml
3.93
180
1374
567
4171
1.45
13.01
1.3
1.2
7.4
11.6
u/ml
1.09
223
1600
800
6301
1.37
12.28
3.2
2.8
1029.2
1166.5
ng/l
0.59
675
5372
100
464
2.20
11.99
3.5
3.0
7.1
7.5
mmol/l
0.96
100
457
2786
26928
2.24
11.87
22.2
19.7
257.6
258.2
e9/l
0.20
2735
26231
1214
10230
1.32
11.76
3.1
2.8
114.7
112.2
ug/l
0.14
1121
9487
2787
26950
2.24
11.72
22.3
19.8
134.7
133.3
g/l
7.26
2760
26563
2786
26943
2.22
11.60
22.2
19.7
4.5
4.4
e12/l
9.16
2729
26164
2786
26946
2.22
11.54
22.2
19.7
6.5
6.6
e9/l
3.29
2730
26156
102
487
2.13
11.40
3.5
2.9
1.4
1.6
mmol/l
1.35
102
477
16
22
7.31
10.98
1.9
1.1
—
—
—
0
0
1577
13887
1.30
10.65
8.6
9.1
3.9
4.0
e9/l
1.95
1421
12088
687
5409
1.36
10.28
1.3
1.2
0.8
1.6
u/ml
3.52
181
1398
1145
9696
1.30
10.26
2.0
1.9
100.7
96.7
pmol/l
1.78
579
4739
622
4874
1.35
9.51
1.7
1.6
45473275.4
43232962.8
pmol/l
0.03
497
4034
196
1234
1.63
9.16
2.8
3.6
1.6
2.0
mmol/l
0.63
135
931
204
1307
1.60
8.88
2.8
3.6
5.1
5.2
kpa
0.64
187
1205
140
815
1.75
8.76
3.0
4.0
24.9
25.0
mmol/l
0.20
127
752
46
181
2.57
8.08
1.2
1.2
72.5
58.2
u/ml
—
6
10
382
2841
1.40
7.98
17.5
23.1
1.2
1.3
inr
0.37
54
404
520
4064
1.34
7.95
1.7
1.7
1047.5
1178.7
nmol/l
2.64
397
3052
152
932
1.67
7.90
4.3
3.7
46.2
48.4
%
0.55
152
922
1050
9033
1.26
7.62
4.5
3.9
—
—
—
0
0
1343
11897
1.24
7.45
5.9
4.9
0.0
0.0
estimate
0.80
267
2121
223
1526
1.50
7.26
1.3
1.3
18.7
47.8
au/ml
—
7
69
82
432
1.92
7.13
1.2
1.3
13.6
14.1
u/l
0.12
69
350
1352
12025
1.24
7.10
4.3
3.7
0.0
0.0
estimate
1.08
269
2112
388
2960
1.36
6.90
2.1
2.2
102.3
108.8
ug/g
0.20
287
2298
151
960
1.60
6.84
1.9
1.9
—
—
—
0
0
240
1690
1.46
6.78
2.4
2.4
20.7
24.8
au/ml
0.26
12
93
69
351
1.99
6.66
1.2
1.4
23.5
32.2
u/l
1.15
57
293
116
696
1.69
6.60
1.4
1.2
26.3
33.7
u/ml
—
9
42
107
629
1.73
6.55
1.4
1.3
1.7
8.0
u/ml
0.74
14
66
108
637
1.72
6.54
1.4
1.3
2.9
4.7
u/ml
0.90
25
114
815
6934
1.25
6.26
4.2
3.9
9.7
8.6
mg/mmol
0.17
474
4127
655
5450
1.26
6.09
1.5
1.5
21.0
20.9
nmol/l
0.04
556
4594
460
3674
1.30
5.92
3.0
3.2
0.8
0.8
mmol/l
2.05
431
3423
1316
11821
1.21
5.84
4.2
3.7
0.0
0.0
estimate
0.50
266
2097
126
800
1.60
5.79
2.0
2.0
12.1
11.7
nmol/l
0.23
106
694
367
2850
1.33
5.78
5.2
5.3
1.0
1.0
mmol/l
0.19
332
2639
66
349
1.91
5.74
1.5
1.4
—
—
—
0
0
676
5693
1.25
5.60
2.2
2.2
3.0
3.0
mg/l
0.06
582
4863
49
237
2.09
5.48
1.3
1.2
—
—
—
0
0
259
1926
1.38
5.41
1.8
1.9
—
—
—
0
0
133
878
1.54
5.20
1.7
1.8
—
—
—
0
0
86
510
1.71
5.18
1.4
1.2
1.1
4.3
u/ml
—
9
39
806
6973
1.22
5.10
3.2
3.1
7.0
7.0
mmol/l
0.01
678
5825
118
762
1.57
5.09
2.0
2.0
—
—
—
0
0
184
1305
1.44
5.06
3.1
3.0
130.9
127.5
g/l
1.44
184
1279
116
759
1.55
4.74
2.1
2.0
4000.0
4414.0
u/l
0.07
42
311
629
5367
1.22
4.50
2.1
1.7
1.0
1.1
mg/l
0.74
500
4109
140
965
1.47
4.50
1.7
2.0
39.0
39.4
u/l
0.10
124
868
144
999
1.46
4.48
2.6
2.7
1.1
1.2
%
0.25
144
991
1732
16181
1.18
4.34
5.1
4.4
1944.3
2446.3
e6/l
0.15
20
201
142
989
1.46
4.34
1.4
1.3
0.2
1.0
u/ml
1.65
13
91
249
1908
1.33
4.32
3.9
3.6
1.9
2.0
mmol/l
0.28
212
1574
106
697
1.54
4.27
1.2
1.4
320.0
289.8
ug/g
0.97
55
386
53
292
1.83
4.16
1.7
1.5
—
—
—
0
0
265
2062
1.31
4.14
3.5
3.1
0.8
0.8
ug/l
0.32
187
1413
53
294
1.82
4.08
1.5
2.1
28.4
25.5
mg/l
—
10
75
277
2180
1.30
3.99
1.9
2.0
—
—
—
0
0
53
297
1.80
3.96
1.8
1.5
—
—
—
0
0
52
291
1.80
3.90
1.8
1.5
—
—
—
0
0
61
358
1.72
3.90
1.3
1.3
0.2
0.4
nmol/l
—
5
20
51
286
1.80
3.81
1.8
1.5
—
—
—
0
0
51
286
1.80
3.81
1.8
1.5
—
—
—
0
0
51
286
1.80
3.81
1.8
1.5
—
—
—
0
0
173
1288
1.37
3.66
1.1
1.0
—
—
—
0
0
383
3170
1.24
3.64
2.5
2.3
2.4
2.3
g/l
0.56
354
2939
24
106
2.27
3.45
1.8
1.8
—
—
—
0
0
412
3463
1.22
3.39
2.6
2.4
13.0
13.1
umol/l
0.18
380
3210
108
754
1.45
3.33
1.9
1.8
—
—
—
0
0
1120
10251
1.15
3.33
4.0
4.6
36.0
35.6
g/l
2.05
1035
9531
198
1530
1.32
3.30
1.2
1.3
106.0
197.6
u/ml
2.77
178
1411
28
136
2.07
3.22
1.6
1.3
—
—
—
0
0
495
4257
1.20
3.21
1.6
1.4
—
—
—
0
0
421
3568
1.21
3.19
5.7
5.1
2.5
2.9
ug/l
0.49
372
3166
24
110
2.19
3.18
2.1
1.6
5.1
4.4
nmol/l
0.09
18
90
77
512
1.52
3.05
3.1
3.3
26.4
26.5
mg/l
0.01
40
318
231
1843
1.28
3.04
2.3
2.8
67.0
66.6
g/l
0.35
204
1683
658
5834
1.17
2.96
2.5
2.4
8866.2
5050.8
umol/l
0.95
557
5042
35
191
1.84
2.92
2.3
2.0
2.2
2.1
u/field
0.01
13
70
95
669
1.43
2.85
1.3
1.3
—
—
—
0
0
10
31
3.23
2.77
1.6
1.7
—
—
—
0
0
349
2947
1.21
2.76
2.6
2.4
22.6
22.8
%
0.09
313
2508
287
2395
1.22
2.56
2.9
3.2
—
—
—
0
0
338
2870
1.20
2.53
4.7
4.4
21.4
21.1
%
0.11
184
1432
11
39
2.83
2.47
1.8
1.3
132.4
85.5
ng/l
0.43
11
39
211
1711
1.25
2.47
1.6
1.7
—
—
—
0
0
286
2397
1.21
2.46
2.2
2.5
1.7
1.8
%
0.77
255
2129
218
1779
1.24
2.42
2.9
3.8
90.7
58.2
u/ml
0.24
211
1721
65
441
1.48
2.41
2.4
2.8
8.2
8.1
kpa
0.18
60
406
696
6283
1.14
2.40
4.5
4.1
0.0
0.0
estimate
1.28
266
2093
213
1738
1.24
2.37
2.8
2.7
10.2
10.4
g/l
0.57
190
1598
21
104
2.03
2.36
1.8
1.4
—
—
—
0
0
21
104
2.03
2.36
1.8
1.4
—
—
—
0
0
14
61
2.30
2.14
4.1
3.2
—
—
—
0
0
74
529
1.41
2.12
1.7
1.4
—
—
—
0
0
419
3682
1.16
2.11
3.0
2.7
3.4
3.4
e6/l
0.04
278
1931
19
95
2.01
2.10
2.3
1.7
—
—
—
0
0
19
95
2.01
2.10
2.3
1.7
—
—
—
0
0
19
95
2.01
2.10
2.3
1.7
—
—
—
0
0
289
2464
1.19
2.10
5.6
4.1
236.0
250.0
u/l
0.83
268
2331
74
532
1.40
2.06
1.4
1.2
26.7
43.2
u/ml
—
9
68
14
63
2.23
2.01
1.1
1.2
152.4
46.7
pmol/l
—
5
18
35
216
1.63
2.00
2.9
2.8
—
—
—
0
0
1593
15206
1.11
1.99
2.9
2.9
—
—
—
0
0
72
522
1.39
1.93
2.2
2.9
24.4
25.0
mmol/l
0.51
63
454
25
143
1.75
1.89
3.2
2.6
697.7
775.4
e6/l
0.26
14
57
90
680
1.33
1.88
1.5
1.3
—
—
—
0
0
5
12
4.17
1.82
1.2
1.3
199.0
329.8
u/l
—
5
12
307
2666
1.17
1.82
3.5
4.0
21.6
19.3
ug/l
0.08
238
2131
25
145
1.73
1.81
1.7
1.3
—
—
—
0
0
23
131
1.76
1.77
1.1
1.2
18.4
25.0
u/l
0.46
17
98
23
131
1.76
1.77
1.1
1.2
60.8
83.3
u/l
1.51
18
100
6
18
3.34
1.74
1.0
1.1
—
—
—
0
0
64
465
1.38
1.73
3.2
3.8
55.7
57.6
%
0.60
64
465
5
13
3.85
1.71
1.2
1.1
—
—
—
0
0
97
752
1.30
1.71
2.0
1.7
1.2
1.2
g/l
0.42
86
713
89
682
1.31
1.71
3.0
3.2
1.4
1.8
ratio
—
8
50
91
701
1.31
1.69
2.9
3.3
44.3
60.0
mg/l
0.71
75
572
24
141
1.71
1.68
1.7
1.3
—
—
—
0
0
94
730
1.30
1.65
2.1
1.7
0.2
0.2
g/l
0.40
84
693
79
599
1.33
1.64
1.8
2.1
10.8
11.7
mg/l
0.53
69
554
16
83
1.93
1.64
1.3
1.6
0.6
0.4
ug/l
—
10
57
20
112
1.79
1.64
2.3
1.6
—
—
—
0
0
20
112
1.79
1.64
2.3
1.6
—
—
—
0
0
20
112
1.79
1.64
2.3
1.6
—
—
—
0
0
20
112
1.79
1.64
2.3
1.6
—
—
—
0
0
91
705
1.30
1.63
2.9
3.3
35.8
47.5
mg/l
0.58
74
576
48
336
1.44
1.61
1.0
1.0
1.0
3.0
u/ml
1.90
14
143
143
1175
1.23
1.58
1.4
1.3
29.7
32.9
iu/l
0.55
127
1022
73
551
1.33
1.58
1.8
1.7
—
—
—
0
0
65
482
1.36
1.57
2.1
2.5
99.0
83.3
ug/min
0.22
38
286
836
7809
1.10
1.53
3.0
3.2
32.6
33.2
u/l
0.09
796
7413
389
3484
1.13
1.53
2.6
2.0
29.2
29.6
s
0.89
378
3364
5
15
3.34
1.52
1.0
1.0
—
—
—
0
0
153
1274
1.21
1.50
1.6
1.5
—
—
—
0
0
18
101
1.79
1.48
1.7
2.0
21.2
98.2
ug/l
0.49
18
90
112
908
1.24
1.42
2.4
2.3
3.6
3.8
g/l
0.35
82
653
88
694
1.28
1.41
2.7
2.3
0.0
0.0
g/l
0.39
82
642
209
1802
1.17
1.40
2.1
2.3
7.0
6.3
ug/l
0.18
174
1565
106
856
1.25
1.40
2.5
2.4
2.9
3.1
g/l
1.63
84
673
407
3678
1.12
1.39
1.8
1.8
—
—
—
0
0
27
174
1.56
1.37
2.1
2.4
747.3
660.5
ml
0.49
20
119
18
104
1.74
1.37
2.3
2.5
—
—
—
0
0
6
23
2.61
1.36
1.8
2.1
—
—
—
0
0
104
841
1.25
1.36
2.4
2.3
10.3
10.3
g/l
0.01
88
720
32
215
1.49
1.35
2.7
3.7
—
—
—
0
0
707
6591
1.10
1.34
1.6
1.6
1.3
1.4
mmol/l
0.57
591
5555
97
780
1.25
1.34
2.6
2.4
0.9
0.9
g/l
0.06
86
687
111
907
1.23
1.33
2.4
2.3
—
—
—
0
0
42
299
1.41
1.33
1.4
1.3
270.4
278.1
pmol/l
0.04
28
238
11
54
2.04
1.32
1.1
1.8
0.6
1.2
mmol/l
0.25
11
48
111
908
1.23
1.32
2.4
2.3
7.2
7.4
g/l
0.91
85
690
9
43
2.10
1.30
1.1
1.1
—
—
—
0
0
5
18
2.78
1.28
1.2
1.3
—
—
—
0
0
11
55
2.00
1.27
1.1
1.1
—
—
—
0
0
90
723
1.25
1.27
2.6
2.2
39.0
37.7
g/l
1.28
79
625
33
227
1.46
1.26
1.1
1.2
—
—
—
0
0
6
25
2.40
1.24
1.3
3.0
1.3
0.8
u/field
—
6
25
21
324
0.65
1.20
1.3
1.5
—
—
—
0
0
6
26
2.31
1.18
1.0
1.0
—
—
—
0
0
6
26
2.31
1.18
1.8
2.1
—
—
—
0
0
525
4868
1.10
1.13
3.0
2.5
6.3
6.7
e6/l
0.14
454
4220
22
143
1.54
1.11
1.1
1.1
0.2
19.0
nmol/l
—
7
20
89
728
1.23
1.10
1.3
1.3
246.2
222.9
miu/ml
0.25
46
351
90
738
1.23
1.09
1.8
1.6
1.5
8.0
iu/ml
0.39
20
156
84
684
1.23
1.09
1.1
1.1
0.9
6.6
u/ml
—
6
71
115
1358
0.84
1.06
5.5
6.4
24.4
24.6
mmol/l
0.41
103
1249
19
121
1.57
1.05
1.1
1.1
—
—
—
0
0
687
6466
1.08
1.05
3.5
3.0
0.3
0.5
e6/l
1.25
543
4788
36
263
1.37
1.03
2.1
2.1
8.7
6.6
umol/l
0.26
22
185
5
22
2.27
1.03
1.2
1.0
—
—
—
0
0
35
255
1.38
1.02
1.1
1.0
—
—
—
0
0
79
645
1.23
1.01
2.8
2.3
0.0
0.0
g/l
0.00
73
596
79
645
1.23
1.01
1.3
1.1
—
—
—
0
0
204
2297
0.88
1.01
2.3
2.3
36.1
39.7
u/l
0.45
169
1948
27
188
1.44
1.01
2.0
1.5
—
—
—
0
0
27
188
1.44
1.01
2.0
1.5
—
—
—
0
0
27
188
1.44
1.01
2.0
1.5
—
—
—
0
0
431
3984
1.10
1.00
2.9
2.6
1.0
1.3
e6/l
0.92
286
2216
7
35
2.00
1.00
1.4
1.1
—
—
—
0
0
56
440
1.28
0.99
1.1
1.1
0.4
1.1
u/ml
1.27
21
165
205
1821
1.14
0.98
7.6
7.1
9.3
9.2
mmol/l
0.06
191
1750
5
23
2.18
0.98
3.2
2.2
—
—
—
0
0
78
639
1.23
0.98
2.9
2.4
0.0
0.0
g/l
0.00
73
595
7
36
1.95
0.97
1.1
1.5
—
—
—
0
0
11
186
0.59
0.95
1.4
1.5
1.0
0.9
g/l
0.23
11
186
14
85
1.65
0.94
1.0
1.1
85.7
213.6
iu/ml
2.54
14
85
19
125
1.52
0.94
1.5
1.8
0.4
3.8
u/field
1.40
14
81
19
125
1.52
0.94
2.2
1.5
1.0
1.3
nmol/l
0.52
14
95
157
1375
1.15
0.93
1.6
1.6
—
—
—
0
0
55
436
1.27
0.93
1.4
1.2
—
—
—
0
0
545
5109
1.08
0.92
4.3
4.1
1.0
1.0
kg/l
0.55
101
761
227
2513
0.89
0.88
4.6
6.8
5.0
5.1
kpa
0.76
212
2392
56
449
1.25
0.87
2.1
2.6
16.2
15.9
%
0.21
32
223
227
2512
0.90
0.87
4.6
6.8
13.5
12.7
kpa
1.15
212
2392
32
238
1.35
0.86
2.1
1.6
—
—
—
0
0
299
2740
1.10
0.85
4.7
6.5
104.8
104.4
mmol/l
0.77
291
2690
17
112
1.52
0.84
2.5
3.0
1050.0
844.7
u/ml
0.19
17
112
44
344
1.28
0.84
1.4
1.4
0.3
0.4
nmol/l
0.36
32
258
16
104
1.54
0.84
2.4
3.3
—
—
—
0
0
30
223
1.35
0.81
2.2
1.6
—
—
—
0
0
47
373
1.26
0.81
1.1
1.1
—
—
—
0
0
49
391
1.26
0.81
1.7
1.6
—
—
—
0
0
227
2499
0.90
0.80
4.6
6.8
1.0
1.2
mmol/l
0.42
172
1939
86
1011
0.85
0.80
1.4
1.5
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
27.2
—
0
17
19
131
1.45
0.78
3.8
2.5
0.3
0.2
e9/l
0.85
19
114
6
34
1.77
0.76
1.2
1.1
—
—
—
0
0
315
2914
1.09
0.76
6.3
6.5
—
—
—
0
0
98
847
1.16
0.74
1.8
1.9
1.5
2.3
ug/l
0.48
82
760
63
754
0.83
0.74
1.7
1.8
—
—
—
0
0
41
325
1.27
0.73
1.0
1.1
48.0
1741.8
iu/ml
—
8
74
15
100
1.50
0.72
1.1
1.3
—
—
—
0
0
297
2747
1.09
0.72
2.3
2.7
6.4
7.8
umol/l
1.17
255
2371
5
26
1.92
0.70
1.2
1.3
—
—
—
0
0
474
4475
1.07
0.69
2.8
3.0
2.4
2.5
mmol/l
1.32
421
3941
105
920
1.15
0.68
1.6
1.7
3.8
3.8
mg/l
0.01
82
659
221
2025
1.10
0.67
1.7
1.7
—
—
—
0
0
5
28
1.79
0.66
1.0
1.5
—
—
—
0
0
25
188
1.33
0.66
1.2
1.3
—
—
—
0
0
25
188
1.33
0.66
1.2
1.1
—
—
titre
—
0
0
11
167
0.66
0.66
1.1
1.7
—
—
—
0
0
12
178
0.67
0.64
1.2
1.6
—
—
—
0
0
5
29
1.73
0.64
1.0
1.0
—
—
—
0
0
188
2058
0.91
0.63
4.8
7.6
121.3
119.9
g/l
0.38
179
1978
39
314
1.25
0.63
1.4
1.3
24.0
49.6
u/ml
—
5
15
28
216
1.30
0.63
2.7
3.4
56.7
56.6
%
0.00
23
149
12
79
1.52
0.62
4.2
1.9
—
—
—
0
0
50
415
1.21
0.62
1.5
1.2
249.4
265.0
u/ml
0.17
33
249
23
302
0.76
0.62
1.9
2.0
813.0
880.1
u/ml
0.02
23
288
11
71
1.55
0.62
1.4
1.5
63.3
65.8
%
0.09
11
57
235
2541
0.92
0.61
1.7
1.7
—
—
—
0
0
208
1912
1.09
0.61
4.3
6.6
1.2
1.3
mmol/l
0.76
201
1853
55
651
0.84
0.60
1.4
1.2
—
—
—
0
0
19
139
1.37
0.60
1.1
1.4
—
755.5
—
0
11
0
21
0.00
0.60
0.0
2.2
—
0.9
—
0
14
15
105
1.43
0.60
1.0
1.4
—
71.1
%
—
0
14
10
151
0.66
0.59
1.4
1.3
—
—
—
0
0
63
735
0.85
0.59
1.2
1.2
—
—
—
0
0
8
54
1.48
0.57
1.5
1.2
—
—
—
0
0
35
283
1.24
0.56
1.2
1.2
59.5
55.5
u/l
0.18
23
196
40
329
1.22
0.56
1.3
1.2
21.6
44.0
u/l
1.17
35
281
8
126
0.63
0.54
1.0
1.2
—
—
—
0
0
41
491
0.83
0.53
1.3
1.3
—
—
—
0
0
41
491
0.83
0.53
1.3
1.3
—
—
—
0
0
24
187
1.29
0.52
1.5
1.1
0.5
0.8
u/ml
—
7
77
43
360
1.20
0.51
2.7
3.5
2.2
1.4
%
0.52
37
289
9
64
1.41
0.51
1.0
1.1
—
—
—
0
0
49
416
1.18
0.51
1.2
1.2
—
—
—
0
0
30
242
1.24
0.51
1.3
1.6
—
—
—
0
0
61
528
1.16
0.50
1.6
1.5
—
—
—
0
0
19
144
1.32
0.50
1.4
1.3
—
—
—
0
0
43
361
1.19
0.50
1.1
1.1
—
—
—
0
0
534
5119
1.05
0.50
1.4
1.4
—
—
—
0
0
6
41
1.46
0.50
1.0
1.9
—
—
—
0
0
72
633
1.14
0.49
1.3
1.4
—
—
—
0
0
22
172
1.28
0.48
1.5
1.6
12.2
6.6
u/l
0.64
11
85
42
354
1.19
0.48
1.1
1.1
—
—
—
0
0
19
146
1.30
0.47
1.4
1.3
—
—
—
0
0
64
728
0.88
0.46
1.2
1.2
—
—
—
0
0
21
165
1.27
0.45
1.3
1.6
—
—
—
0
0
12
86
1.40
0.44
12.7
14.1
0.7
0.6
mmol/l
0.68
12
78
7
51
1.37
0.44
2.1
4.1
—
—
—
0
0
7
51
1.37
0.44
2.1
4.1
—
—
—
0
0
15
196
0.76
0.42
1.5
1.5
6.2
6.6
mmol/l
0.18
15
187
2187
22083
0.96
0.42
15.2
14.4
38.8
39.2
%
0.92
1542
15883
10
70
1.43
0.41
1.1
1.2
—
—
—
0
0
60
529
1.14
0.41
1.6
1.5
—
—
—
0
0
5
33
1.52
0.41
1.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
21.7
—
0
8
40
466
0.86
0.41
1.7
1.6
—
—
—
0
0
58
511
1.14
0.40
3.0
3.1
31.0
956.4
u/ml
1.13
51
466
35
296
1.18
0.40
1.3
1.5
—
—
—
0
0
53
603
0.88
0.40
3.9
3.5
15.5
29.4
u/ml
3.67
53
586
0
18
0.00
0.40
0.0
1.1
—
45.5
—
0
5
33
388
0.85
0.38
1.5
1.6
—
—
—
0
0
11
80
1.38
0.38
1.5
2.4
—
36954.8
—
0
13
35
298
1.18
0.38
1.4
1.5
54.4
58.8
%
0.29
21
189
22
179
1.23
0.37
1.3
1.6
—
—
—
0
0
204
1923
1.07
0.37
3.0
2.5
65.7
66.8
ml/min/173m2
0.17
98
745
8
116
0.69
0.37
1.6
1.7
—
—
—
0
0
38
438
0.87
0.35
1.3
1.5
—
—
—
0
0
42
367
1.15
0.34
1.2
1.2
8.6
5.0
u/ml
0.52
19
128
83
908
0.91
0.34
1.4
1.5
—
—
—
0
0
12
91
1.32
0.33
1.2
1.1
1781.8
1562.7
miu/ml
0.20
12
91
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
10
74
1.35
0.32
1.2
1.1
115.4
117.4
%
—
10
68
12
92
1.31
0.31
1.9
1.8
—
—
—
0
0
33
380
0.87
0.31
1.5
1.7
—
—
—
0
0
17
138
1.23
0.30
1.0
1.4
—
54.4
—
0
16
46
515
0.89
0.30
1.3
1.5
—
—
—
0
0
61
553
1.11
0.30
3.3
3.2
1.6
1.5
mg/l
0.37
51
515
243
2541
0.95
0.29
1.7
1.7
—
—
—
0
0
126
1343
0.94
0.29
1.7
1.8
—
—
—
0
0
8
106
0.75
0.29
13.1
12.2
825.6
871.8
nmol/l
—
8
100
36
317
1.14
0.28
1.1
1.4
—
—
—
0
0
18
149
1.21
0.27
1.1
1.0
—
—
—
0
0
42
375
1.12
0.27
1.3
1.2
5.6
4.5
u/ml
0.12
16
106
19
159
1.20
0.26
3.6
1.9
—
—
—
0
0
52
472
1.10
0.26
1.5
1.5
—
—
—
0
0
5
75
0.67
0.25
3.4
2.5
110.6
146.1
nmol/l
—
5
64
16
132
1.21
0.25
1.4
1.4
5.7
5.8
mmol/l
0.15
16
127
46
415
1.11
0.25
1.3
2.2
0.8
0.8
nmol/l
0.11
35
347
69
747
0.92
0.25
2.4
2.8
—
—
—
0
0
14
114
1.23
0.25
1.1
1.3
—
—
—
0
0
14
114
1.23
0.25
1.1
1.3
—
—
—
0
0
13
105
1.24
0.24
1.2
1.2
—
—
—
0
0
11
87
1.27
0.24
1.3
1.6
—
—
—
0
0
107
1133
0.94
0.22
5.7
9.0
24.6
24.4
mmol/l
0.27
97
1070
59
639
0.92
0.22
4.0
3.9
3.9
3.8
mmol/l
0.50
52
605
235
2265
1.04
0.22
2.1
2.1
0.2
0.2
g/l
0.89
222
2135
19
221
0.86
0.22
1.5
1.4
56201.1
48026.5
e6/l
0.06
12
121
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
5.1
—
365.2
—
0
10
16
135
1.19
0.21
1.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
61
657
0.93
0.21
1.9
1.7
—
—
—
0
0
6
49
1.22
0.20
1.0
1.1
—
—
—
0
0
6
49
1.22
0.20
1.0
1.3
—
—
—
0
0
12
144
0.83
0.19
1.4
1.3
9.0
10.9
u/l
0.50
12
134
103
977
1.06
0.19
1.8
1.7
1.5
1.6
g/l
0.26
88
841
15
175
0.86
0.18
1.7
1.4
294.5
329.9
u/l
0.15
15
170
27
301
0.90
0.18
1.2
1.1
—
—
—
0
0
7
58
1.21
0.18
1.1
1.1
—
—
—
0
0
7
59
1.19
0.18
1.1
1.1
—
—
—
0
0
52
484
1.08
0.17
1.8
2.3
130.7
126.6
g/l
0.53
40
339
8
70
1.14
0.16
1.0
1.0
—
—
—
0
0
18
158
1.14
0.16
1.1
1.1
—
—
—
0
0
34
312
1.09
0.15
1.2
1.3
7.1
7.4
mmol/l
0.18
26
230
54
506
1.07
0.15
1.3
1.4
8.5
31.7
e6/l
1.48
43
377
62
584
1.06
0.15
1.7
1.6
15205.2
10964.8
e6/l
0.28
45
434
19
168
1.13
0.15
3.6
1.9
17.0
13.4
%
—
6
71
6
76
0.79
0.15
1.5
1.5
8.4
9.0
ug/l
—
6
76
121
1259
0.96
0.15
1.5
1.4
—
—
—
0
0
9
79
1.14
0.15
1.1
1.1
—
—
—
0
0
62
585
1.06
0.15
1.8
1.4
—
—
—
0
0
54
507
1.07
0.15
1.4
1.4
1037.3
1278.7
e6/l
0.12
47
400
16
140
1.14
0.15
1.1
1.5
—
—
—
0
0
35
323
1.08
0.14
1.8
1.5
—
—
—
0
0
453
4451
1.02
0.14
3.7
3.5
192.0
339.1
ng/l
0.50
316
3319
20
223
0.90
0.14
1.1
1.1
—
85.0
—
0
5
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
73
694
1.05
0.14
2.9
2.8
0.3
0.4
u/ml
0.62
48
389
21
189
1.11
0.13
1.2
1.1
—
—
—
0
0
24
218
1.10
0.13
1.2
1.4
38.0
33.6
%
0.24
14
135
45
422
1.07
0.13
3.1
3.1
0.8
0.8
nmol/l
0.10
34
327
21
190
1.11
0.12
1.2
1.1
—
—
—
0
0
79
756
1.05
0.12
1.9
2.2
245.7
769.2
ug/l
1.11
70
706
14
123
1.14
0.12
1.0
1.1
—
—
—
0
0
28
259
1.08
0.11
1.1
1.1
—
—
—
0
0
19
208
0.91
0.10
1.1
1.0
—
—
—
0
0
19
173
1.10
0.10
1.0
1.3
—
—
—
0
0
2006
20133
0.99
0.10
17.7
16.3
13.6
13.7
%
1.51
1965
19709
23
249
0.92
0.10
1.4
1.5
6041.2
2377.5
e6/l
0.33
17
176
27
251
1.08
0.10
1.1
1.5
1.9
4.1
ug/l
1.22
21
208
47
447
1.05
0.10
1.5
1.3
—
17.6
—
0
10
12
135
0.89
0.09
1.1
1.1
—
—
—
0
0
183
1866
0.98
0.08
3.3
2.7
201.7
174.6
ng/l
0.39
166
1699
6
70
0.86
0.07
1.3
1.2
—
—
—
0
0
20
215
0.93
0.07
1.5
1.6
—
—
—
0
0
8
74
1.08
0.07
1.0
1.1
—
—
—
0
0
39
408
0.96
0.07
1.1
1.4
—
—
—
0
0
52
539
0.96
0.07
1.3
1.6
—
—
—
0
0
46
478
0.96
0.06
1.5
1.4
—
—
—
0
0
96
982
0.98
0.06
4.2
3.9
24.6
24.2
mmol/l
0.45
84
891
46
477
0.96
0.06
1.5
1.4
—
—
—
0
0
46
477
0.96
0.06
1.5
1.4
—
—
—
0
0
46
476
0.97
0.05
1.5
1.4
—
—
—
0
0
10
90
1.11
0.05
1.7
1.2
—
—
—
0
0
12
110
1.09
0.05
1.5
1.5
—
—
—
0
0
34
353
0.96
0.04
1.1
1.4
—
—
—
0
0
20
189
1.06
0.04
1.2
1.1
—
—
—
0
0
110
1118
0.98
0.04
1.3
1.4
—
—
—
0
0
104
1057
0.98
0.04
1.5
1.7
—
—
—
0
0
20
190
1.05
0.04
1.2
1.1
—
—
—
0
0
20
190
1.05
0.04
1.2
1.1
—
—
—
0
0
21
200
1.05
0.03
1.0
1.1
—
—
—
0
0
13
121
1.07
0.03
1.1
1.6
—
—
—
0
0
13
122
1.07
0.02
1.1
1.6
—
—
—
0
0
10
93
1.08
0.02
3.5
5.0
—
—
—
0
0
11
117
0.94
0.01
1.0
1.1
—
—
—
0
0
13
137
0.95
0.01
1.3
1.5
9.8
12.7
u/l
1.32
13
132
41
402
1.02
0.01
1.3
1.3
104.2
123.4
u/ml
0.51
11
80
17
163
1.04
0.01
1.0
1.0
328.1
351.5
ng/l
0.21
12
112
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
13
124
1.05
0.00
1.0
1.1
—
—
—
0
0
24
234
1.03
0.00
1.4
1.3
15851.2
61316.0
e6/l
0.70
16
162
250
2494
1.00
0.00
1.6
1.7
1.4
1.4
%
0.17
219
2183
17
165
1.03
0.00
1.0
1.0
693.6
729.5
ng/l
0.13
12
110
24
241
1.00
0.00
1.5
1.2
—
—
—
0
0
30
301
1.00
0.00
1.1
1.4
—
—
—
0
0
13
126
1.03
0.00
1.0
1.0
1.3
1.1
u/l
—
6
69
13
132
0.98
0.00
1.1
1.1
—
—
—
0
0
17
167
1.02
0.00
1.0
1.0
47.1
47.8
ng/l
0.03
12
114
5
54
0.93
0.00
1.0
1.1
—
—
—
0
0
7
74
0.95
0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
1.4
1.3
—
—
—
0
0
8
85
0.94
0.00
1.0
1.3
—
—
—
0
0
9
92
0.98
0.00
1.2
1.1
—
—
—
0
0
6
59
1.02
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.3
—
0
5
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
91
910
1.00
0.00
3.0
3.4
214.7
2109.5
u/ml
0.98
71
771
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
32.4
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GOITRENOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITRENOD | 0.933 [0.84, 1.03] | 0.168 |
| Birth year | 0.994 [0.99, 1.0] | 0.161 |
During the follow-up period (1.1.1998 — 31.12.2019), 978 out of 10026 females with E4_GOITRENOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITRENOD | 0.863 [0.76, 0.98] | 0.019 |
| Birth year | 0.993 [0.98, 1.0] | 0.145 |
During the follow-up period (1.1.1998 — 31.12.2019), 395 out of 2426 males with E4_GOITRENOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_GOITRENOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.064% | 0.205% |
| 5 | 0.56% | 1.157% |
| 10 | 1.27% | 3.068% |
| 15 | 2.514% | 5.741% |
| 20 | 4.303% | 10.132% |
Relationships between endpoints
↥Index endpoint: E4_GOITRENOD – Nontoxic single thyroid nodule
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data