otitis externa: Inflammation of the anatomical structures of the outer ear and ear canal secondary to an infectious process. Bacterial etiology is most common, but fungal infection is also possible. Symptoms include erythema, edema, and pain.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2333 |
4. Check minimum number of eventsNone |
2333 |
5. Include endpointsNone |
2333 |
6. Filter based on genotype QC (FinnGen only) |
2333 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H60
- Name in latin
- Alia otitis externa infectiosa
Similar endpoints
↥List of similar endpoints to
Other infective otitis externa
based on the number of shared cases.
Similar with more cases:
- Otitis externa
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16526 | 8526 | 7935 |
| Only index persons | 15476 | 8098 | 7378 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.23 | 0.24 | 0.22 |
| Only index persons | 0.29 | 0.30 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 46.95 | 45.50 | 48.53 |
| Only index persons | 47.01 | 45.65 | 48.51 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2333 | 1303 | 1030 |
| Unadjusted period prevalence (%) | 0.45 | 0.44 | 0.45 |
| Median age at first event (years) | 52.78 | 48.38 | 58.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2110
- Matched controls
- 21100
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1103
7366
1.94
52.51
2.2
1.9
95.9
95.3
pmol/l
0.14
570
3924
1261
9068
1.85
45.26
6.8
5.9
57.2
56.9
%
0.26
1167
8540
440
2205
2.23
45.13
4.8
4.3
31.8
32.3
%
0.39
308
1536
1264
9196
1.82
42.67
7.2
6.0
28.2
28.3
%
0.03
1166
8629
1151
8204
1.80
41.02
6.9
6.1
1.2
1.2
mmol/l
2.99
1055
7437
1751
14470
1.84
34.70
8.3
7.4
76.6
77.8
u/l
0.54
1667
13648
1704
13980
1.81
34.41
4.7
4.0
12.5
11.7
mm/h
1.38
1579
12976
505
2919
1.93
34.25
3.0
2.9
3.4
2.3
e6/l
1.31
290
1591
1210
9061
1.70
33.63
8.1
6.8
1.2
1.2
mmol/l
1.63
1089
7660
1269
9680
1.68
32.40
5.6
6.1
10.5
11.4
umol/l
3.24
1203
9176
1399
10961
1.69
32.16
5.3
4.8
6.9
6.7
mmol/l
2.06
1320
10214
332
1727
2.08
30.06
2.6
2.4
28.5
67.8
u/l
0.81
274
1476
231
1041
2.35
29.84
1.7
1.6
—
—
—
0
0
690
4561
1.73
29.47
2.5
2.4
—
—
—
0
0
1393
11047
1.65
29.21
9.4
8.9
4.2
4.1
e9/l
0.39
1184
9691
1987
17493
1.92
27.16
5.7
4.6
1.9
2.1
mu/l
1.00
1806
16133
2121
19124
2.20
26.84
18.3
13.6
22.2
23.3
mg/l
0.86
1795
15068
502
3101
1.79
26.81
2.9
2.7
1.0
1.1
e6/l
0.43
286
1761
471
2886
1.79
25.74
2.0
1.8
—
—
—
0
0
173
738
2.45
25.17
5.1
4.3
24.7
24.9
mmol/l
0.32
160
698
1041
7884
1.58
24.82
5.6
4.9
35.7
35.7
g/l
0.01
959
7332
576
3778
1.70
24.58
1.5
1.5
2.5
2.4
g/l
0.42
308
2354
384
2246
1.85
24.33
24.5
23.4
1.1
1.3
inr
3.73
37
343
2003
17847
1.86
24.01
16.3
12.4
83.7
83.0
ml/min/173m2
0.68
1687
14697
766
5459
1.60
23.31
2.1
2.1
165.1
234.6
u/l
1.78
729
5135
537
3503
1.69
23.21
3.9
3.6
482.9
450.1
ng/l
0.06
392
2619
2133
19463
2.12
23.09
20.3
15.4
139.5
139.7
mmol/l
1.97
2083
18973
1526
12744
1.57
22.70
3.6
3.1
50.8
47.6
u/l
0.58
1426
11942
2136
19530
2.11
22.52
20.6
15.5
4.0
4.0
mmol/l
0.40
2080
19008
359
2112
1.83
22.18
2.4
2.7
9.1
8.1
umol/l
0.25
314
1841
499
3229
1.69
22.10
1.8
1.7
973.2
1161.6
nmol/l
5.18
353
2486
599
4137
1.60
20.27
1.6
1.5
19.9
20.5
nmol/l
0.41
517
3572
597
4169
1.58
19.10
1.7
1.7
1.1
1.1
mg/l
0.01
451
3165
985
7670
1.49
18.96
2.6
2.2
75.7
76.5
nmol/l
0.36
885
6939
837
6310
1.51
18.83
3.3
3.2
33.1
33.1
u/l
0.00
788
5999
1062
8412
1.48
18.68
3.2
2.8
110.1
121.5
ug/l
1.12
981
7833
695
5088
1.52
17.75
3.6
3.1
0.3
0.4
e6/l
1.67
517
3825
672
4910
1.52
17.23
2.9
3.0
1438.1
1319.1
ng/l
0.27
551
4173
601
4294
1.54
17.08
1.4
1.3
1.6
1.5
u/ml
0.03
99
1147
1676
14661
1.51
17.07
4.5
4.0
14.6
14.7
pmol/l
0.92
1510
13426
154
739
2.16
16.98
2.1
1.9
—
—
—
0
0
141
658
2.22
16.66
1.9
1.8
—
—
—
0
0
1909
17223
1.60
16.48
7.1
5.5
41.0
39.6
mmol/mol
7.62
1743
16026
216
1186
1.91
16.40
5.0
3.9
5.2
5.1
kpa
0.36
203
1106
662
4864
1.50
16.37
2.8
2.7
1355.0
4972.2
umol/l
3.73
573
4246
480
3288
1.58
16.36
1.3
1.3
25.1
31.5
iu/ml
0.51
128
1043
206
1124
1.91
15.93
5.0
3.9
1.1
1.8
mmol/l
1.86
164
833
764
5804
1.47
15.91
4.0
3.2
7.5
7.7
mmol/l
0.63
618
4941
641
4706
1.50
15.82
2.5
2.2
2.9
2.9
mg/l
0.07
525
4016
264
1583
1.75
15.02
7.9
7.5
1.3
1.4
mmol/l
0.80
256
1517
1456
12572
1.42
14.42
3.4
3.1
—
—
—
0
0
2161
20299
1.88
14.20
12.6
10.0
27.7
26.5
u/l
1.73
2089
19628
275
1733
1.67
12.98
2.2
2.3
0.2
0.2
g/l
0.61
253
1615
307
1990
1.62
12.96
1.9
1.7
—
—
—
0
0
165
896
1.91
12.94
4.6
4.4
24.1
24.0
mmol/l
0.11
152
817
350
2351
1.57
12.72
2.7
2.4
147.4
126.5
ug/g
0.43
263
1883
172
952
1.87
12.72
10.2
10.2
24.2
24.3
mmol/l
0.11
161
899
743
5807
1.41
12.62
2.7
2.5
54.1
56.6
u/l
1.11
682
5371
724
5646
1.41
12.41
4.8
4.0
10.1
8.9
mg/mmol
0.26
482
3630
384
2648
1.54
12.40
2.8
2.4
2.3
2.3
g/l
0.45
352
2454
122
606
2.07
12.33
1.7
1.7
—
—
—
0
0
782
6197
1.39
12.14
3.4
3.4
2.4
2.4
mmol/l
0.17
661
5461
360
2459
1.55
12.12
2.9
2.5
22.5
23.4
%
0.74
314
2099
408
2867
1.51
12.04
2.8
2.5
13.2
13.4
umol/l
0.23
372
2656
2147
20268
1.74
11.92
20.3
15.6
79.0
76.5
umol/l
1.97
2147
20261
201
1197
1.74
11.66
1.2
1.3
—
47.6
—
0
58
1976
18308
1.52
11.64
5.4
4.4
6.1
5.9
mmol/l
6.58
1805
16786
87
388
2.29
11.53
1.3
1.3
—
—
—
0
0
87
388
2.29
11.53
1.3
1.3
—
—
—
0
0
302
2008
1.58
11.41
1.9
1.8
—
—
—
0
0
437
3153
1.47
11.27
1.3
1.2
19.0
11.5
u/ml
0.27
136
1263
2231
21354
2.02
11.22
26.6
19.9
253.1
251.8
e9/l
0.42
2177
20831
2232
21369
2.03
11.18
26.6
19.8
4.5
4.5
e12/l
0.12
2173
20782
59
223
2.69
11.12
2.3
2.3
19.8
25.5
mg/l
0.49
16
59
2232
21373
2.02
11.11
26.7
19.9
7.0
6.7
e9/l
3.97
2175
20790
2232
21377
2.02
11.04
26.8
19.9
135.0
135.6
g/l
1.28
2205
21083
1911
17653
1.46
10.77
20.4
14.5
40.1
39.9
%
0.51
1474
13021
415
2990
1.47
10.73
3.3
3.4
0.8
0.8
mmol/l
1.67
380
2812
350
2445
1.51
10.53
7.8
5.8
1.0
1.0
mmol/l
0.19
316
2270
115
593
1.99
10.52
1.4
1.4
—
—
—
0
0
215
1348
1.66
10.31
5.0
4.0
100.4
88.6
ng/l
0.72
184
1186
838
6864
1.34
10.11
3.6
3.5
45.4
55.4
ng/l
0.29
548
4527
20
38
5.30
10.11
1.1
1.1
—
—
—
0
0
210
1317
1.65
10.06
2.4
2.4
12.5
22.2
au/ml
1.12
11
85
342
2401
1.50
10.02
1.7
1.7
1.5
1.5
%
0.95
300
2114
1055
8978
1.32
9.63
4.0
4.1
—
—
—
0
0
117
627
1.91
9.59
2.3
2.5
2.9
3.1
g/l
1.26
92
494
102
528
1.97
9.26
1.5
1.4
279.3
284.2
ug/g
0.08
53
305
121
668
1.86
9.07
2.3
2.4
—
—
—
0
0
121
668
1.86
9.07
2.3
2.4
7.4
7.3
g/l
0.22
96
504
48
182
2.67
9.05
1.3
1.2
44.4
56.8
u/l
1.19
26
125
192
1219
1.63
8.77
1.4
1.3
547.2
201.0
u/ml
0.72
180
1131
293
2048
1.49
8.73
3.9
4.2
231.6
247.3
u/l
1.49
278
1944
203
1310
1.60
8.67
1.7
1.6
—
—
—
0
0
106
571
1.90
8.59
2.1
2.5
0.1
1.1
g/l
6.02
93
500
119
668
1.82
8.48
2.3
2.4
3.7
3.8
g/l
0.83
91
483
577
7139
0.75
8.36
3.8
3.6
—
—
—
0
0
98
523
1.91
8.18
2.2
2.3
39.1
37.7
g/l
1.75
85
456
432
3295
1.38
7.95
3.3
3.0
2.4
2.4
mmol/l
0.03
383
2887
53
225
2.39
7.95
1.5
1.5
—
—
—
0
0
53
225
2.39
7.95
1.5
1.5
—
—
—
0
0
378
4958
0.72
7.93
4.3
3.8
0.0
0.0
estimate
1.08
115
1703
78
389
2.04
7.90
1.2
1.2
1.5
4.7
u/ml
—
8
29
94
501
1.91
7.89
2.3
2.3
0.0
0.0
g/l
0.54
88
460
53
226
2.38
7.88
1.5
1.5
—
—
—
0
0
98
531
1.88
7.82
1.3
1.2
4.0
50.5
u/ml
—
5
30
53
227
2.37
7.80
1.5
1.5
—
—
—
0
0
79
398
2.02
7.79
1.4
1.4
—
—
—
0
0
217
1461
1.54
7.71
2.2
2.7
10.5
10.5
g/l
0.06
198
1345
2015
19055
1.42
7.70
5.5
4.7
2.7
2.8
mmol/l
1.11
1838
17671
53
229
2.34
7.66
1.5
1.5
—
—
—
0
0
53
229
2.34
7.66
1.5
1.5
—
—
—
0
0
491
3856
1.35
7.46
2.7
2.5
6.2
6.0
e6/l
0.11
414
3367
109
621
1.79
7.43
2.3
2.5
9.8
10.2
g/l
0.58
95
530
611
4956
1.32
7.42
1.7
1.7
1.5
1.4
mmol/l
2.15
550
4173
165
1055
1.61
7.34
1.6
1.5
—
—
—
0
0
91
493
1.88
7.29
1.3
1.2
21.3
10.5
u/ml
0.39
17
80
88
473
1.89
7.22
2.3
2.3
0.0
0.0
g/l
0.00
82
433
374
2829
1.38
7.20
2.0
2.1
30.4
29.8
s
0.78
363
2742
89
486
1.86
6.97
1.3
1.2
5.8
2.6
u/ml
—
10
47
83
1479
0.55
6.97
4.9
3.7
1.2
1.2
mmol/l
0.14
75
1274
1981
18745
1.38
6.95
5.0
4.3
4.6
4.7
mmol/l
3.37
1811
17504
233
1631
1.48
6.88
9.8
7.4
10.8
9.6
mmol/l
1.40
211
1555
86
469
1.87
6.77
2.4
2.3
0.0
0.0
g/l
0.00
80
432
32
115
2.81
6.74
1.6
1.6
11.4
7.5
u/l
0.28
14
60
1905
17967
1.33
6.44
4.4
3.8
1.4
1.3
mmol/l
5.85
1723
16588
59
289
2.07
6.34
5.4
5.8
346.3
363.9
umol/l
0.46
54
255
23
71
3.26
6.28
1.7
1.4
—
—
—
0
0
23
71
3.26
6.28
1.7
1.4
—
—
—
0
0
286
2122
1.40
6.15
2.3
1.9
—
—
—
0
0
28
99
2.85
6.10
1.3
1.1
20.7
26.0
u/l
0.38
23
72
311
2344
1.38
6.08
2.4
2.1
—
—
—
0
0
95
556
1.74
5.97
1.9
1.7
0.2
0.2
g/l
1.16
90
528
206
1453
1.46
5.86
2.8
2.7
67.2
66.4
g/l
0.82
182
1337
234
1692
1.43
5.83
4.7
4.0
1.4
1.9
mmol/l
1.53
197
1338
273
2029
1.39
5.81
2.6
2.7
1.8
1.8
%
0.04
230
1809
1960
18630
1.33
5.76
5.0
4.2
1.4
1.5
mmol/l
10.68
1783
17288
27
97
2.80
5.73
1.6
1.9
—
—
—
0
0
27
97
2.80
5.73
1.6
1.9
—
—
—
0
0
27
97
2.80
5.73
1.6
1.9
—
—
—
0
0
27
97
2.80
5.73
1.6
1.9
—
—
—
0
0
234
1700
1.42
5.68
4.7
4.0
5.9
5.9
kpa
0.42
228
1648
114
711
1.63
5.67
1.4
1.2
0.4
1.0
u/ml
—
6
63
447
3591
1.30
5.66
1.7
1.6
—
—
—
0
0
15
37
4.07
5.63
1.0
1.1
—
—
—
0
0
35
145
2.44
5.62
1.2
1.1
—
—
—
0
0
35
145
2.44
5.62
1.2
1.1
—
—
—
0
0
25
87
2.89
5.62
1.8
1.4
—
—
—
0
0
35
146
2.42
5.55
1.2
1.1
—
—
—
0
0
23
77
3.01
5.53
1.6
2.1
—
—
—
0
0
23
77
3.01
5.53
1.6
2.1
—
—
—
0
0
23
77
3.01
5.53
1.6
2.1
—
—
—
0
0
25
88
2.86
5.51
1.8
1.4
—
—
—
0
0
58
301
1.95
5.37
1.5
1.3
—
—
—
0
0
47
226
2.10
5.35
1.3
1.4
—
—
—
0
0
11
22
5.02
5.26
1.3
1.4
47.5
49.7
umol/l
0.07
11
22
34
144
2.38
5.23
1.2
1.1
—
—
—
0
0
34
144
2.38
5.23
1.2
1.1
—
—
—
0
0
71
398
1.81
5.20
1.3
1.2
8.3
45.2
u/ml
—
8
31
124
807
1.57
5.19
2.1
1.9
1.6
1.5
g/l
0.72
111
704
190
1358
1.43
5.06
2.3
1.9
—
—
—
0
0
19
60
3.18
5.04
1.2
1.1
—
—
—
0
0
23
82
2.82
4.98
1.6
3.1
126.9
114.8
umol/l
—
9
49
48
247
1.96
4.60
2.8
1.7
1792.0
1506.7
titre
—
5
6
11
25
4.42
4.56
1.2
1.0
—
—
—
0
0
90
565
1.62
4.43
1.2
1.2
—
—
—
0
0
34
156
2.20
4.40
1.2
1.3
—
—
—
0
0
37
176
2.12
4.39
3.1
4.0
—
—
—
0
0
18
62
2.92
4.17
1.1
1.3
—
—
—
0
0
35
167
2.11
4.13
3.1
3.3
58.8
54.8
%
0.35
23
113
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
93
601
1.57
4.08
3.0
3.1
0.3
0.3
u/ml
0.80
47
333
92
594
1.57
4.06
1.7
1.9
—
—
—
0
0
88
563
1.59
4.04
1.2
1.2
—
—
—
0
0
187
1392
1.37
3.98
3.8
3.3
4.8
4.6
kpa
0.56
180
1346
149
1068
1.42
3.96
2.2
1.8
—
—
—
0
0
90
583
1.57
3.92
2.4
2.7
—
—
—
0
0
185
1379
1.37
3.91
2.1
2.2
11.9
12.8
nmol/l
0.61
149
1227
24
102
2.37
3.74
1.3
1.2
15.0
16.0
u/l
0.07
19
88
11
30
3.68
3.64
4.1
6.1
—
—
—
0
0
22
91
2.43
3.64
9.8
5.9
41.6
40.2
u/ml
—
10
20
193
1466
1.35
3.63
3.3
2.9
179.5
191.2
ng/l
0.19
168
1329
29
136
2.15
3.61
1.3
1.2
—
—
—
0
0
229
1786
1.31
3.60
3.1
4.2
15.5
21.8
ug/l
0.23
183
1453
137
989
1.41
3.53
11.1
10.9
—
—
—
0
0
86
567
1.54
3.50
2.2
2.6
3.9
3.6
g/l
0.84
78
532
28
133
2.12
3.39
1.7
2.5
941.4
722.3
e6/l
0.79
14
56
115
811
1.44
3.38
1.6
1.9
38.3
39.0
u/l
0.15
99
721
13
42
3.11
3.37
1.0
1.2
115.8
102.0
ug/l
—
8
17
7
10
7.02
3.36
8.6
3.8
—
—
—
0
0
75
485
1.56
3.34
1.4
1.3
—
—
—
0
0
81
536
1.53
3.27
1.4
1.3
—
—
—
0
0
177
1350
1.34
3.27
1.2
1.2
160.6
158.3
iu/ml
0.02
56
516
21
90
2.35
3.24
1.0
1.0
—
—
—
0
0
48
281
1.72
3.16
3.5
3.2
1.5
1.4
%
0.08
35
226
49
291
1.70
3.08
1.2
1.1
—
—
—
0
0
222
1764
1.29
3.06
2.4
2.1
395.2
372.6
nmol/l
0.83
202
1627
23
106
2.18
3.03
1.6
1.5
—
—
—
0
0
45
264
1.72
2.96
1.5
1.5
—
—
—
0
0
254
2066
1.26
2.90
8.7
8.0
5.2
5.1
kpa
0.82
244
1970
254
2067
1.26
2.89
8.7
8.0
11.6
12.4
kpa
1.70
245
1973
253
2058
1.26
2.89
8.7
8.0
0.6
1.0
mmol/l
0.75
204
1604
36
200
1.81
2.85
1.4
1.4
2701.3
1716.2
e6/l
0.48
27
137
60
384
1.58
2.84
5.1
5.4
422.0
730.7
iu/ml
—
5
52
77
521
1.49
2.84
1.1
1.1
24.3
4.7
u/ml
0.52
12
69
16
356
0.45
2.78
1.4
1.5
—
—
—
0
0
133
998
1.35
2.77
1.1
1.0
—
—
—
0
0
55
347
1.60
2.77
1.2
1.2
—
372.5
—
0
8
21
98
2.15
2.71
2.0
2.2
39.6
146.4
ug/min
—
8
23
67
447
1.51
2.66
1.4
1.7
6524.1
14206.0
e6/l
1.73
42
331
12
43
2.80
2.64
1.1
1.1
—
—
—
0
0
32
177
1.82
2.60
3.8
4.7
45.4
65.3
u/ml
—
7
46
9
25
3.61
2.57
1.1
1.5
—
—
—
0
0
264
2191
1.23
2.54
5.3
6.7
—
—
—
0
0
49
308
1.60
2.53
1.3
1.2
5.5
5.3
u/ml
0.05
23
135
22
108
2.05
2.51
1.2
2.0
—
—
—
0
0
75
520
1.46
2.49
1.2
1.1
—
—
—
0
0
74
515
1.45
2.42
5.2
4.0
1.6
1.5
mg/l
0.24
68
475
14
58
2.42
2.37
1.4
3.1
—
—
—
0
0
151
1185
1.29
2.34
2.6
3.3
4.4
4.5
pmol/l
0.47
127
1056
48
731
0.65
2.32
1.6
1.9
—
—
—
0
0
22
112
1.97
2.30
2.0
1.4
1.3
1.3
nmol/l
0.02
16
89
8
23
3.49
2.27
1.3
1.0
—
—
—
0
0
22
113
1.96
2.25
1.2
1.3
—
—
—
0
0
662
6000
1.14
2.25
5.1
4.8
2.1
3.0
ug/l
2.56
580
5387
24
430
0.55
2.24
2.1
1.7
—
—
—
0
0
75
533
1.42
2.22
1.8
1.8
—
—
—
0
0
58
395
1.48
2.15
2.2
3.0
34.7
35.4
umol/l
0.09
52
337
8
25
3.21
2.09
2.5
1.4
—
—
—
0
0
71
506
1.42
2.09
1.6
2.1
12.0
11.0
mg/l
0.48
65
464
27
153
1.77
2.08
1.3
1.2
88.6
203.0
titre
—
7
30
22
117
1.89
2.06
1.2
1.1
—
—
—
0
0
183
1497
1.24
2.05
1.9
2.4
6.1
7.4
ug/l
0.65
146
1346
145
1156
1.27
2.03
11.9
9.6
93.3
94.0
%
0.60
145
1149
30
177
1.70
2.02
1.5
1.4
39525.5
78109.9
e6/l
0.42
17
102
74
535
1.40
2.01
1.8
1.7
46.2
40.0
nmol/l
1.11
67
518
119
926
1.30
2.01
3.4
3.2
100.4
51.0
u/ml
0.67
112
895
398
3505
1.16
2.01
3.4
3.0
0.8
0.7
ug/l
0.06
299
2309
96
725
1.34
2.00
1.6
1.5
333.4
308.7
mu/l
0.31
88
653
121
945
1.30
1.99
1.5
1.4
22.5
27.8
iu/l
1.10
102
795
77
562
1.38
1.99
1.3
1.4
11.1
9.8
u/l
0.38
59
449
13
57
2.29
1.97
1.0
1.1
—
—
—
0
0
53
363
1.47
1.94
1.6
1.6
—
—
—
0
0
55
380
1.46
1.93
1.9
1.8
174.6
204.9
pmol/l
1.07
50
361
23
397
0.58
1.92
3.8
3.8
26.9
25.4
mg/l
—
10
260
42
275
1.54
1.90
1.4
1.4
27.9
26.0
u/l
0.14
29
225
28
166
1.70
1.87
1.6
1.7
—
—
—
0
0
28
166
1.70
1.87
1.6
1.7
—
—
—
0
0
28
166
1.70
1.87
1.6
1.7
—
—
—
0
0
5
12
4.17
1.82
1.4
1.2
—
—
—
0
0
143
1155
1.25
1.82
12.0
9.6
0.6
0.7
%
1.63
143
1146
21
364
0.57
1.80
6.0
3.3
7.5
7.6
mmol/l
0.06
21
357
29
461
0.62
1.77
1.4
1.5
—
—
—
0
0
1666
16109
1.12
1.71
22.3
16.3
13.7
13.6
%
0.81
1641
15758
38
250
1.53
1.71
2.4
2.2
6.8
7.1
umol/l
0.06
29
178
16
82
1.96
1.69
2.4
2.5
—
—
—
0
0
22
369
0.59
1.68
3.3
2.5
16.8
16.3
%
0.25
12
190
53
375
1.42
1.67
1.1
1.1
0.7
2.0
u/ml
1.30
26
157
11
49
2.25
1.63
1.1
1.2
292.2
310.8
pmol/l
—
5
37
118
946
1.26
1.63
2.6
2.9
0.3
0.2
e6/l
0.28
113
919
65
480
1.36
1.61
1.3
1.2
—
—
—
0
0
5
14
3.58
1.61
1.0
1.1
—
—
—
0
0
45
313
1.45
1.57
1.1
1.1
2.9
3.1
u/ml
0.04
13
80
141
1161
1.23
1.55
12.1
9.5
1.3
1.4
%
0.11
141
1153
20
115
1.75
1.52
1.1
1.0
—
—
—
0
0
5
15
3.34
1.52
1.2
1.1
—
—
—
0
0
21
123
1.71
1.51
1.4
1.5
18.8
21.6
u/ml
—
5
29
16
86
1.87
1.50
1.3
1.9
—
—
—
0
0
67
505
1.34
1.48
1.4
1.4
—
—
—
0
0
37
251
1.48
1.48
1.2
1.3
—
—
—
0
0
67
506
1.33
1.47
1.4
1.4
—
—
—
0
0
163
1928
0.83
1.46
3.3
3.2
—
—
—
0
0
47
649
0.72
1.46
1.4
1.5
—
—
—
0
0
14
254
0.55
1.45
1.7
1.6
—
—
—
0
0
67
507
1.33
1.45
1.4
1.4
—
—
—
0
0
67
508
1.33
1.43
1.4
1.4
—
—
—
0
0
9
39
2.31
1.43
1.1
1.2
—
—
—
0
0
24
376
0.63
1.43
3.2
3.6
3.7
4.1
e9/l
0.73
24
376
46
329
1.41
1.41
1.2
1.1
1.7
1642.3
iu/ml
—
7
81
45
321
1.41
1.40
1.3
1.2
2.6
3.4
u/ml
0.40
16
114
7
29
2.42
1.39
1.1
1.2
—
—
—
0
0
39
272
1.44
1.37
1.1
1.1
1.5
1.5
g/l
0.15
34
247
28
183
1.54
1.34
1.5
1.7
—
—
—
0
0
27
175
1.55
1.34
1.1
1.0
—
—
—
0
0
0
38
0.00
1.34
0.0
1.2
—
135.6
—
0
26
22
136
1.62
1.32
2.3
1.6
—
—
—
0
0
55
411
1.35
1.31
1.8
1.3
—
12.5
—
0
7
6
24
2.50
1.30
7.0
9.5
4.8
6.2
mmol/l
—
6
24
26
390
0.66
1.29
4.3
3.9
52.1
57.3
%
0.99
26
390
20
122
1.64
1.27
1.2
1.2
—
—
—
0
0
6
25
2.40
1.24
1.3
1.0
—
—
—
0
0
20
124
1.62
1.20
1.2
1.2
—
—
—
0
0
55
418
1.32
1.20
1.5
1.2
—
—
—
0
0
18
109
1.66
1.18
1.2
1.6
6.5
9.6
ug/l
0.74
18
94
8
38
2.11
1.18
1.9
2.3
21.6
17.2
umol/l
—
8
38
21
133
1.58
1.17
1.1
2.2
11.0
14.3
%
0.96
16
65
23
149
1.55
1.17
1.3
1.4
1.4
1.2
promille
0.15
18
121
64
499
1.29
1.17
1.2
1.4
—
—
—
0
0
26
174
1.50
1.15
3.2
2.6
—
—
—
0
0
79
635
1.25
1.14
1.3
1.3
217.7
228.7
miu/ml
0.10
40
293
23
151
1.53
1.11
1.2
1.2
1.7
0.7
u/ml
0.26
13
67
34
243
1.41
1.09
1.1
1.1
11.3
5.6
u/ml
0.47
14
97
5
21
2.38
1.09
1.0
1.0
—
—
—
0
0
15
89
1.69
1.07
1.1
1.2
—
—
—
0
0
21
137
1.54
1.05
2.0
1.4
77.1
265.0
pmol/l
0.44
12
45
7
33
2.12
1.05
1.0
1.2
—
—
—
0
0
19
121
1.57
1.05
1.5
2.0
—
—
—
0
0
9
46
1.96
1.03
1.2
1.2
—
—
—
0
0
5
22
2.28
1.03
1.2
1.3
—
—
—
0
0
5
22
2.28
1.03
1.6
2.0
—
—
—
0
0
5
22
2.28
1.03
1.8
1.5
87.6
119.4
ng/l
—
5
22
19
122
1.56
1.02
1.0
1.1
0.7
2.8
nmol/l
—
5
22
96
803
1.20
0.98
3.7
3.0
0.6
0.7
%
1.08
91
775
19
124
1.54
0.96
1.1
2.3
—
—
—
0
0
66
532
1.25
0.96
2.1
1.7
—
—
—
0
0
6
116
0.52
0.94
1.7
1.5
—
—
—
0
0
36
269
1.34
0.92
1.1
1.1
10.4
3.9
u/ml
0.96
13
100
68
554
1.23
0.91
1.4
1.5
—
—
—
0
0
89
746
1.20
0.91
2.3
2.1
2832.8
4331.8
u/l
0.27
30
302
15
94
1.60
0.90
1.5
1.7
—
—
—
0
0
15
94
1.60
0.90
1.5
1.7
—
—
—
0
0
66
540
1.23
0.86
2.9
3.6
25.2
71.4
mg/l
1.20
57
433
53
423
1.26
0.86
1.8
1.5
—
—
—
0
0
25
178
1.41
0.86
1.1
1.7
—
—
—
0
0
40
308
1.30
0.85
1.1
1.1
—
—
—
0
0
54
669
0.80
0.85
1.3
1.5
—
—
—
0
0
41
317
1.30
0.85
1.1
1.1
—
—
—
0
0
61
496
1.24
0.85
1.7
1.9
4.7
4.8
iu/l
0.02
16
176
21
145
1.45
0.85
1.1
1.1
—
—
—
0
0
30
222
1.36
0.83
1.1
1.1
92.0
96.1
%
0.36
30
209
31
410
0.75
0.82
2.6
2.2
132.6
130.5
g/l
0.14
17
303
47
373
1.27
0.81
2.7
3.4
41.5
1064.7
u/ml
0.87
42
347
28
206
1.36
0.81
1.5
1.7
—
—
—
0
0
30
224
1.34
0.80
1.0
1.0
3.4
0.4
u/ml
—
10
59
0
25
0.00
0.79
0.0
1.2
—
—
—
0
0
11
66
1.67
0.78
1.3
1.6
—
—
—
0
0
75
630
1.20
0.78
2.7
3.4
104.3
6297.6
u/ml
0.79
64
531
65
539
1.21
0.77
2.9
3.6
52.1
69.8
mg/l
0.41
58
431
121
1059
1.15
0.77
1.4
1.3
—
—
—
0
0
14
92
1.52
0.72
1.2
1.2
185.7
217.6
iu/ml
0.22
14
92
7
40
1.75
0.71
1.0
1.1
—
—
—
0
0
955
9225
1.06
0.70
3.6
3.5
0.0
0.0
estimate
0.00
109
1740
166
1496
1.12
0.69
3.8
2.5
69.3
68.3
ml/min/173m2
0.13
68
566
21
152
1.39
0.69
1.0
1.1
—
—
—
0
0
10
61
1.64
0.68
1.9
1.5
14.0
13.5
pmol/l
—
10
52
5
27
1.85
0.68
1.0
1.2
—
—
—
0
0
39
312
1.25
0.66
1.5
1.4
0.4
0.3
nmol/l
0.65
30
245
5
95
0.53
0.66
1.8
1.6
—
—
—
0
0
18
128
1.41
0.65
1.0
1.0
776.9
712.8
ng/l
0.22
12
78
5
29
1.73
0.64
1.0
1.2
—
—
—
0
0
35
278
1.26
0.64
1.2
1.1
7.4
2.2
u/ml
1.09
18
129
18
129
1.40
0.63
1.0
1.0
39.4
44.4
ng/l
0.28
13
79
8
50
1.60
0.61
2.3
2.6
—
—
—
0
0
8
50
1.60
0.61
2.3
2.6
—
—
—
0
0
54
453
1.20
0.61
2.3
2.4
103.6
113.4
ug/min
0.07
35
286
48
398
1.21
0.61
1.6
1.3
198.2
249.5
u/ml
1.12
31
238
0
20
0.00
0.60
0.0
1.1
—
23.3
—
0
14
9
141
0.64
0.60
1.7
1.6
—
—
—
0
0
89
780
1.15
0.60
1.6
1.7
3.6
3.8
mg/l
0.09
66
547
0
22
0.00
0.59
0.0
1.4
—
—
—
0
0
10
64
1.56
0.58
1.0
1.4
—
90.5
—
0
34
68
586
1.17
0.57
1.6
1.6
25.1
11.3
iu/ml
0.21
14
107
5
89
0.56
0.56
2.2
2.8
—
—
—
0
0
10
65
1.54
0.55
1.2
1.5
—
—
—
0
0
10
66
1.52
0.52
1.0
1.1
—
91.7
—
0
35
6
96
0.62
0.52
1.2
1.4
—
68.4
%
—
0
11
6
96
0.62
0.52
1.7
1.6
—
—
—
0
0
950
9240
1.05
0.52
5.1
4.8
0.0
0.0
estimate
0.50
120
1778
6
41
1.46
0.50
2.2
2.9
—
—
—
0
0
52
447
1.17
0.48
1.6
1.6
—
—
—
0
0
17
128
1.33
0.47
1.0
1.0
294.2
305.6
ng/l
0.09
12
81
71
626
1.14
0.47
1.6
1.4
—
—
—
0
0
76
852
0.89
0.44
4.3
3.3
24.5
25.3
mmol/l
1.24
76
822
18
230
0.78
0.43
1.3
1.1
—
—
—
0
0
20
157
1.28
0.43
1.4
1.4
—
—
—
0
0
25
203
1.23
0.42
1.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
5.7
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
15
194
0.77
0.40
1.6
1.7
—
—
—
0
0
19
150
1.27
0.40
1.5
1.2
—
—
—
0
0
28
232
1.21
0.40
1.1
1.1
—
—
—
0
0
8
61
1.31
0.39
1.0
1.1
—
—
—
0
0
955
9338
1.04
0.39
3.6
3.5
0.0
0.0
estimate
0.37
111
1706
30
251
1.20
0.39
1.3
1.5
—
—
—
0
0
37
318
1.17
0.36
1.6
1.7
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
14
108
1.30
0.35
1.0
1.1
—
—
—
0
0
23
191
1.21
0.33
1.1
1.2
—
—
—
0
0
21
174
1.21
0.31
1.6
2.6
—
—
—
0
0
13
164
0.79
0.30
1.3
2.0
18.8
20.4
nmol/l
0.22
13
153
26
221
1.18
0.30
1.0
1.1
—
—
—
0
0
17
138
1.23
0.30
1.0
1.2
—
—
—
0
0
27
231
1.17
0.29
1.0
1.1
—
—
—
0
0
7
56
1.25
0.29
1.0
1.1
—
—
—
0
0
7
57
1.23
0.29
1.0
1.1
—
—
—
0
0
13
103
1.26
0.28
1.1
1.1
—
—
—
0
0
10
76
1.32
0.28
3.1
4.0
—
—
—
0
0
9
119
0.76
0.27
1.3
1.2
—
—
—
0
0
495
4819
1.03
0.27
4.1
4.3
23.1
21.6
%
1.27
238
2337
389
4011
0.96
0.26
3.6
3.8
1.0
1.0
kg/l
0.46
67
569
90
966
0.93
0.26
1.4
1.5
—
—
—
0
0
77
712
1.08
0.26
2.0
2.0
2.1
1.8
ug/l
0.14
61
632
36
320
1.13
0.25
1.3
1.5
—
—
—
0
0
171
1792
0.95
0.24
1.8
1.7
—
—
—
0
0
9
76
1.18
0.24
1.0
1.0
—
—
—
0
0
20
171
1.17
0.23
1.4
1.4
14.3
12.0
mmol/l
0.38
12
41
5
39
1.28
0.23
1.4
1.0
85.6
42.6
u/ml
—
5
39
0
11
0.00
0.21
0.0
1.7
—
21.7
—
0
6
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
45
411
1.10
0.21
3.7
2.2
0.9
0.8
nmol/l
0.11
36
344
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
14
117
1.20
0.20
1.6
1.5
—
—
—
0
0
6
48
1.25
0.20
1.0
1.1
—
—
—
0
0
6
53
1.13
0.18
1.0
1.3
—
—
—
0
0
7
59
1.19
0.18
1.4
1.4
7.5
9.3
ug/l
—
7
59
7
61
1.15
0.17
1.0
1.1
—
—
—
0
0
8
71
1.13
0.16
1.1
1.2
—
—
—
0
0
9
81
1.11
0.15
1.4
2.1
17.3
119.0
ug/l
—
9
70
7
87
0.80
0.14
1.0
1.1
1582.9
1652.2
miu/ml
—
7
87
40
372
1.08
0.14
1.5
1.4
—
—
—
0
0
12
139
0.86
0.14
1.4
1.6
—
—
—
0
0
23
252
0.91
0.12
1.3
1.5
—
—
—
0
0
17
152
1.12
0.12
1.5
2.2
0.6
2.0
u/field
—
5
70
47
444
1.06
0.11
1.2
1.5
18.8
31.6
e6/l
0.32
36
348
47
444
1.06
0.11
1.3
1.5
112.3
1201.5
e6/l
1.11
36
363
50
475
1.05
0.10
3.8
3.2
24.7
24.7
mmol/l
0.05
42
413
307
3119
0.98
0.10
1.4
1.5
—
—
—
0
0
14
126
1.11
0.09
1.0
1.1
0.9
1.1
u/l
—
5
58
29
273
1.06
0.08
1.1
1.1
—
—
—
0
0
76
784
0.97
0.08
4.7
3.8
52.7
48.8
%
0.62
76
774
13
143
0.91
0.07
1.3
1.5
1.0
1.0
g/l
0.08
13
143
45
433
1.04
0.06
1.6
1.7
—
—
—
0
0
35
335
1.05
0.06
3.3
3.0
0.8
0.8
nmol/l
0.00
21
258
14
151
0.93
0.05
2.8
1.9
3.7
4.3
mg/l
0.22
14
145
389
3865
1.01
0.04
1.7
1.7
54902365.3
35135563.8
pmol/l
0.20
306
3256
17
162
1.05
0.02
3.2
3.5
30.9
47.4
u/ml
0.48
17
162
28
288
0.97
0.02
1.4
1.4
—
—
—
0
0
15
156
0.96
0.00
2.2
2.2
656.8
621.9
ml
—
9
103
12
121
0.99
0.00
1.0
1.1
—
—
—
0
0
11
108
1.02
0.00
1.6
1.6
—
—
—
0
0
34
342
0.99
0.00
2.0
1.7
—
—
—
0
0
23
233
0.99
0.00
1.1
1.7
61.8
60.7
%
0.04
12
148
0
8
0.00
0.00
0.0
1.4
—
2.4
—
0
8
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1765.2
—
0
5
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
0.00
1.3
1.2
108.7
109.0
%
—
6
58
6
61
0.98
0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.2
—
0
5
18
180
1.00
0.00
1.1
1.4
5791.0
113797.5
e6/l
—
9
125
6
65
0.92
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
0.00
1.0
1.1
—
—
—
0
0
9
93
0.97
0.00
1.7
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
9
93
0.97
0.00
1.2
2.6
528.8
1249.7
u/ml
—
9
93
0
6
0.00
0.00
0.0
5.0
—
382.8
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXT_INFNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_INFNAS | 1.229 [1.08, 1.4] | 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.402 |
During the follow-up period (1.1.1998 — 31.12.2019), 922 out of 7274 females with H8_EXT_INFNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_INFNAS | 1.296 [1.15, 1.46] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.025 |
During the follow-up period (1.1.1998 — 31.12.2019), 1222 out of 6899 males with H8_EXT_INFNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXT_INFNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.084% | 0.247% |
| 5 | 0.761% | 1.604% |
| 10 | 1.791% | 4.07% |
| 15 | 3.653% | 7.977% |
| 20 | 6.526% | 13.166% |
Relationships between endpoints
↥Index endpoint: H8_EXT_INFNAS – Other infective otitis externa
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data