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Other diseases of gallbladder

DOID EFO Endpoint Browser PheWeb

K11_GALLBLAOTH

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — K82
  • Hospital discharge: ICD-9 — 575[3-9]
  • Hospital discharge: ICD-8 — 57600|57602|57604
  • Cause of death: ICD-10 — K82
  • Cause of death: ICD-9 — 575[3-9]
  • Cause of death: ICD-8 — 57600|57602|57604

2 out of 7 registries used, show all original rules.

1717

4. Check minimum number of events

None

1717

5. Include endpoints

None

1717

6. Filter based on genotype QC (FinnGen only)

1717

Control definitions (FinnGen only)

Control exclude
K11_GALLBILPANC

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K80-K87
Name in latin
Alii morbi vesicae biliaris

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 14816 9612 5039
Only index persons 11458 7755 3703
Unadjusted period prevalence (%)
Whole population 0.23 0.28 0.14
Only index persons 0.24 0.29 0.14
Median age at first event (years)
Whole population 53.44 50.94 58.14
Only index persons 50.54 48.38 55.05

-FinnGen-

Key figures

All Female Male
Number of individuals 1717 1088 629
Unadjusted period prevalence (%) 0.34 0.37 0.28
Median age at first event (years) 49.72 45.48 57.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1535
Matched controls
15348
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
173.1
323.0
359
27
57600
ICD-8 Finland
Other diseases of gallbladder and biliary, Cholesterosis vesicae felleae
+∞
323.0
344
*
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
965.3
323.0
517
8
K82.8
ICD-10 Finland
Other specified diseases of gallbladder
3072.5
286.5
268
*
K82.9
ICD-10 Finland
Disease of gallbladder, unspecified
2588.0
247.6
233
*
K82.4
ICD-10 Finland
Cholesterolosis of gallbladder
+∞
209.2
196
*
K82.2
ICD-10 Finland
Perforation of gallbladder
+∞
162.4
153
*
5756A
ICD-9 Finland
Other disorders of gallbladder, Cholesterolosis of gallbladder
+∞
159.2
150
*
K80.0
ICD-10 Finland
Calculus of gallbladder with acute cholecystitis
+∞
123.6
117
*
JKA20
NOMESCO Finland
Cholecystectomy
50.4
114.2
138
30
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.5
108.3
719
3082
6662
FHL
Cholecystectomy
554.7
106.0
104
*
6663
FHL
Cholecystectomy and cholangiography
441.0
84.9
84
*
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
142.3
76.7
81
6
K82.0
ICD-10 Finland
Obstruction of gallbladder
+∞
75.6
72
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.8
73.7
363
1155
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
32.9
68.3
90
29
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.2
63.9
215
467
K80.1
ICD-10 Finland
Calculus of gallbladder with other cholecystitis
+∞
58.7
56
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.6
55.9
569
2878
5759X
ICD-9 Finland
Other disorders of gallbladder, Unspecified disorder of gallbladder
+∞
53.4
51
*
UJK02
NOMESCO Finland
ERCP
30.0
51.4
69
24
K81.0
ICD-10 Finland
Acute cholecystitis
172.1
48.1
50
*
57409
ICD-8 Finland
Cholelithiasis, Unspecified
+∞
47.1
45
*
K83.0
ICD-10 Finland
Cholangitis
471.4
46.5
46
*
A02BC05
ATC
esomeprazole; systemic
2.2
45.1
704
4275
K85
ICD-10 Finland
Acute pancreatitis
123.7
45.0
48
*
A02BC02
ATC
pantoprazole; systemic
2.1
41.8
1045
7668
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
40.7
223
740
N02AX02
ATC
tramadol; systemic, rectal
2.1
40.2
698
4369
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
40.0
252
927
5742A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder without mention of cholecystitis[CHOLECYSTOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
+∞
39.7
38
*
K81.9
ICD-10 Finland
Cholecystitis, unspecified
397.1
39.2
39
*
5758X
ICD-9 Finland
Other disorders of gallbladder, Other specified disorders of gallbladder
+∞
38.7
37
*
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
194.6
36.9
38
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
38.6
35.7
45
12
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
10.3
34.0
68
69
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
33.9
290
1275
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
44.4
31.9
39
9
K83.1
ICD-10 Finland
Obstruction of bile duct
168.4
31.8
33
*
A02BC03
ATC
lansoprazole; oral
2.0
30.8
509
3030
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
52.6
30.4
36
7
K80.8
ICD-10 Finland
Other cholelithiasis
52.6
30.4
36
7
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
+∞
30.3
29
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
29.9
447
2552
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
29.3
464
2705
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
+∞
29.3
28
*
A02BA02
ATC
ranitidine; systemic
2.2
29.1
368
1952
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
25.6
28.9
40
16
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
28.8
428
2429
JN3AD
NOMESCO Finland
Abdominal CT examination
3.4
28.1
144
452
UJF32
NOMESCO Finland
Coloscopy
2.0
27.5
443
2589
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
26.8
689
4751
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
25.2
574
3772
K82.3
ICD-10 Finland
Fistula of gallbladder
+∞
25.1
24
*
A02BC01
ATC
omeprazole; systemic
1.9
24.5
465
2867
J01MA02
ATC
ciprofloxacin; systemic
1.8
24.0
610
4139
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.1
23.4
314
1688
TJK01
NOMESCO Finland
Laparoscopic cholangiography
+∞
23.0
22
*
K80.4
ICD-10 Finland
Calculus of bile duct with cholecystitis
+∞
21.9
21
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
29.5
21.9
29
10
P01AB01
ATC
metronidazole; oral, rectal
1.7
20.3
590
4113
ZXE00
NOMESCO Finland
One hour or less
1.7
20.2
596
4171
K30
ICD-10 Finland
Functional dyspepsia
2.4
19.9
179
794
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
19.6
297
1666
R03AC02
ATC
salbutamol; inhalant
1.6
19.5
746
5596
N03AX16
ATC
pregabalin; oral
1.8
19.2
371
2268
K85.0
ICD-10 Finland
Idiopathic acute pancreatitis
+∞
18.8
18
*
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
3.1
18.7
107
363
N02BE01
ATC
paracetamol; systemic, rectal
1.8
18.2
1279
11249
ZXD05
NOMESCO Finland
Urgent procedure
1.7
17.8
443
2921
K85.8
ICD-10 Finland
Other acute pancreatitis
+∞
17.7
17
*
K82.1
ICD-10 Finland
Hydrops of gallbladder
+∞
17.7
17
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
181.9
17.5
18
*
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
8.4
17.5
38
46
WX402
NOMESCO Finland
General anaesthesia
2.0
17.3
232
1236
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
17.1
318
1907
A05AA02
ATC
ursodeoxycholic acid; oral
8.1
17.1
38
48
J01DB01
ATC
cefalexin; oral
1.7
16.8
1172
10101
H02AB06
ATC
prednisolone; systemic
1.6
16.6
685
5162
M79.6
ICD-10 Finland
Pain in limb
1.6
16.5
519
3642
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
15.7
579
4228
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
+∞
15.6
15
*
D06
ICPC
Abdominal pain localized other
2.5
15.1
124
523
WX002
NOMESCO Finland
Sedation and analgesia
1.8
15.1
310
1915
D02
ICPC
Abdominal pain epigastric
3.1
15.0
82
271
A03FA02
ATC
cisapride; oral, rectal
2.3
15.0
148
688
R10.0
ICD-10 Finland
Acute abdomen
4.2
15.0
57
140
5754A
ICD-9 Finland
Other disorders of gallbladder, Perforation of gallbladder
+∞
14.6
14
*
57401
ICD-8 Finland
Cholelithiasis, Cum cholecystitide chronica
+∞
14.6
14
*
TJK00
NOMESCO Finland
Intraoperative cholangiography
80.9
14.6
16
*
D01
ICPC
Abdominal pain/cramps general
2.2
14.5
147
692
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
14.5
878
7159
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
14.4
268
1599
A03CA02
ATC
clidinium and psycholeptics; oral
2.5
14.4
114
473
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
14.6
14.1
23
16
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
13.9
358
2359
JAH01
NOMESCO Finland
Laparoscopy
3.2
13.9
72
230
J01MA12
ATC
levofloxacin; systemic
1.8
13.8
272
1654
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.0
13.7
174
901
K86.1
ICD-10 Finland
Other chronic pancreatitis
+∞
13.6
13
*
57408
ICD-8 Finland
Cholelithiasis, Alia definita
+∞
13.6
13
*
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
13.5
152
750
J01DA01
ATC
[U] cefalexin; systemic
1.5
13.5
895
7387
Z2221
NOMESCO Finland
Medical doctor
1.6
13.5
405
2779
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
13.3
516
3771
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.1
13.2
158
797
M03BX02
ATC
tizanidine; oral
1.5
13.2
828
6735
M25.5
ICD-10 Finland
Pain in joint
1.6
13.2
380
2577
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
13.2
217
1241
M01AE03
ATC
ketoprofen; systemic, rectal
1.5
13.1
554
4133
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
13.1
140
677
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.9
13.0
81
294
H02AB04
ATC
methylprednisolone; systemic
1.9
12.9
217
1251
C07AB07
ATC
bisoprolol; oral
1.5
12.9
711
5616
A09AA02
ATC
multienzymes (lipase, protease etc.)
8.1
12.8
28
35
R4110
NOMESCO Finland
Physiotherapy
1.6
12.8
384
2633
M54.5
ICD-10 Finland
Low back pain
1.6
12.7
444
3162
UJK12
NOMESCO Finland
Peroral cholangioscopy
70.4
12.6
14
*
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
12.5
253
1545
C03CA01
ATC
furosemide; systemic
1.6
12.5
465
3356
M01AH05
ATC
etoricoxib; oral
1.5
12.5
783
6338
Z3226
NOMESCO Finland
Physiotherapist
1.7
12.5
279
1758
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
131.0
12.4
13
*
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
131.0
12.4
13
*
K80
ICD-10 Finland
Cholelithiasis
13.3
12.4
21
16
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
12.3
284
1809
D98
ICPC
Cholecystitis/cholelithiasis
26.9
12.0
16
6
R53
ICD-10 Finland
Malaise and fatigue
1.7
12.0
300
1950
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.0
11.8
164
880
B01AB05
ATC
enoxaparin; parenteral
1.5
11.7
431
3094
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
11.6
207
1215
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
11.5
238
1466
Z3231
NOMESCO Finland
Registered nurse
1.6
11.5
391
2754
J01FA06
ATC
roxithromycin; oral
1.5
11.5
578
4445
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
11.4
286
1856
R51.80
ICD-10 Finland
Headache
1.8
11.3
188
1077
C01DA14
ATC
isosorbide mononitrate; oral
1.7
11.3
252
1586
J45
ICD-10 Finland
Asthma
2.0
11.3
144
750
M01AH01
ATC
celecoxib; oral (coxibs)
1.7
11.2
265
1694
J01FA09
ATC
clarithromycin; systemic
1.5
11.2
418
3005
J02AC01
ATC
fluconazole; systemic
1.5
11.1
543
4141
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.9
11.0
162
890
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.6
11.0
352
2441
R96
ICPC
Asthma
2.0
10.9
135
693
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.7
10.8
273
1776
R01AD09
ATC
mometasone; nasal
1.5
10.8
585
4547
M70.6
ICD-10 Finland
Trochanteric bursitis
1.8
10.7
193
1138
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.8
10.6
70
262
M48.0
ICD-10 Finland
Spinal stenosis
1.8
10.5
193
1139
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.6
10.5
272
1782
D13.5
ICD-10 Finland
Benign neoplasm: Extrahepatic bile ducts
110.7
10.4
11
*
5740A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder with acute cholecystitis[CHOLECYSTOLITHIASIS CUM CHOLECYSTITIDE AC,SINE OBST]
+∞
10.4
10
*
5741A
ICD-9 Finland
Cholelithiasis, Calculus of gallbladder with other cholecystitis[CHOLECYSTOLITHIASIS CUM CHOLECYSTITIDE CHR,SINE OBS]
+∞
10.4
10
*
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
6.4
10.3
26
41
A02BA04
ATC
nizatidine; systemic
2.0
10.3
133
695
R06.0
ICD-10 Finland
Dyspnoea
1.5
10.3
353
2479
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
3.0
10.3
57
193
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.7
10.3
206
1254
R03DC03
ATC
montelukast; oral
1.7
10.3
209
1278
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
10.1
223
1396
M54.4
ICD-10 Finland
Lumbago with sciatica
1.7
9.9
217
1352
R07.3
ICD-10 Finland
Other chest pain
2.0
9.9
135
719
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.5
9.8
356
2534
A02BC04
ATC
rabeprazole; oral
2.0
9.7
120
615
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
9.7
513
3949
M01AE02
ATC
naproxen; oral, rectal
1.4
9.7
734
6046
J01AA02
ATC
doxycycline; systemic
1.5
9.6
1124
10021
J01FA10
ATC
azithromycin; systemic
1.4
9.6
738
6089
AA1AD
NOMESCO Finland
CT of head and brain
1.5
9.6
341
2412
78551
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Symptomata abdominalis acuta NUD
3.1
9.6
52
174
R13
ICD-10 Finland
Dysphagia
2.2
9.6
101
485
G47.3
ICD-10 Finland
Sleep apnoea
1.6
9.5
257
1699
K29.7
ICD-10 Finland
Gastritis, unspecified
2.8
9.5
60
221
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
9.5
186
1125
K86.2
ICD-10 Finland
Cyst of pancreas
100.6
9.4
10
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.6
9.4
302
2084
57609
ICD-8 Finland
Other diseases of gallbladder and biliary, Alii definiti sive NUD
+∞
9.4
9
*
K81.1
ICD-10 Finland
Chronic cholecystitis
+∞
9.4
9
*
5770A
ICD-9 Finland
Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA NONALCOHOLICA NONHAEMORRHAGICA]
+∞
9.4
9
*
57500
ICD-8 Finland
Cholecystitis and cholangitis, without mention of calculus, Cholecystitis acuta
+∞
9.4
9
*
K82
ICD-10 Finland
Other diseases of gallbladder
+∞
9.4
9
*
N05BA01
ATC
diazepam; systemic, rectal
1.7
9.3
196
1210
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
9.2
645
5216
M01AH02
ATC
rofecoxib; oral
1.7
9.2
201
1255
UJD02
NOMESCO Finland
Gastroscopy
2.4
9.2
78
338
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
3.9
9.1
36
94
M03BC51
ATC
orphenadrine, combinations; systemic
1.5
9.1
360
2602
M02AA07
ATC
piroxicam; topical
1.4
9.1
534
4182
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
9.0
138
771
N03AX12
ATC
gabapentin; oral
1.7
9.0
211
1345
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
8.9
320
2263
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
8.8
310
2183
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
8.8
424
3190
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.2
8.7
84
390
ZXA05
NOMESCO Finland
Left side
1.5
8.6
374
2754
WX110
NOMESCO Finland
Local anesthesy
1.4
8.6
891
7683
M01AX17
ATC
nimesulide; oral
1.5
8.6
350
2545
A03DA02
ATC
pitofenone and analgesics; systemic
3.3
8.5
41
127
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.0
8.5
111
586
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
8.5
194
1228
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
8.4
279
1934
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
5.1
8.3
25
50
57708
ICD-8 Finland
Diseases of pancreas, Pancreatitis acuta alia
+∞
8.3
8
*
JKB00
NOMESCO Finland
Incision of bile duct
+∞
8.3
8
*
57608
ICD-8 Finland
Other diseases of gallbladder and biliary, Dyskinesia viarum biliferarum
+∞
8.3
8
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
8.3
599
4847
R03AK07
ATC
formoterol and budesonide; inhalant
1.6
8.2
242
1629
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.0
8.2
106
556
R05
ICD-10 Finland
Cough
1.6
8.1
252
1721
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
8.1
141
820
L04AX01
ATC
azathioprine; systemic
2.5
8.1
60
245
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
3.9
8.1
31
80
N06AX21
ATC
duloxetine; oral
1.8
8.1
134
769
I20.09
ICD-10 Finland
Unstable angina
2.1
8.0
86
418
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.5
8.0
356
2630
J01CA04
ATC
amoxicillin; systemic
1.4
7.9
1086
9746
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.6
7.9
55
216
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.7
7.9
51
192
J01EA01
ATC
trimethoprim; systemic
1.4
7.8
370
2768
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
7.7
227
1530
XF600
NOMESCO Finland
Bloodpressure measurement
2.0
7.7
93
476
8140/3-C23.9
ICD-O-3
Adenocarcinoma, NOS, of gallbladder
45.2
7.7
9
*
M54.3
ICD-10 Finland
Sciatica
2.1
7.7
81
390
M01AB55
ATC
diclofenac, combinations; oral
1.9
7.7
105
563
R03BA02
ATC
budesonide; inhalant
1.6
7.7
235
1600
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
7.7
334
2453
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.5
7.6
298
2140
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
6.7
7.6
18
27
R01AD08
ATC
fluticasone; nasal
1.4
7.6
357
2664
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
25.1
7.6
10
*
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
2.2
7.6
76
361
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
2.7
7.5
48
178
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
2.7
7.5
49
186
R03AC03
ATC
terbutaline; inhalant
1.6
7.5
186
1199
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.1
7.5
80
389
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
7.5
344
2555
J01MA01
ATC
ofloxacin; systemic
1.8
7.5
127
735
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
1.8
7.4
118
667
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
7.4
649
5388
ZXA10
NOMESCO Finland
Bilateral
1.5
7.4
265
1868
E66.01
ICD-10 Finland
Obesity due to excess calories
2.1
7.4
81
396
A11
ICPC
Chest pain NOS
1.9
7.4
110
610
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
7.3
129
753
L17
ICPC
Foot/toe symptom/complaint
1.4
7.3
337
2502
K85.1
ICD-10 Finland
Biliary acute pancreatitis
+∞
7.3
7
*
57709
ICD-8 Finland
Diseases of pancreas, Pancreatitis NUD
+∞
7.3
7
*
5750A
ICD-9 Finland
Other disorders of gallbladder, Acute cholecystitis
+∞
7.3
7
*
5745A
ICD-9 Finland
Cholelithiasis, Calculus of bile duct without mention of cholecystitis[CHOLEDOCHOLITHIASIS SINE CHOLECYSTITIDE,SINE OBSTR]
+∞
7.3
7
*
R05
ICPC
Cough
1.5
7.3
277
1977
A41.9
ICD-10 Finland
Sepsis, unspecified
2.5
7.3
54
220
A03FA01
ATC
metoclopramide; systemic, rectal
1.5
7.2
282
2025
R42
ICD-10 Finland
Dizziness and giddiness
1.5
7.2
299
2174
XKC03
NOMESCO Finland
Water cystometry
2.6
7.2
50
197
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.8
7.2
126
735
A02BA03
ATC
famotidine; systemic
2.2
7.2
68
315
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
7.1
683
5744
R21
ICPC
Throat symptom/complaint
1.6
7.1
200
1332
R06AE07
ATC
cetirizine; oral
1.4
7.1
557
4540
A02BDXX
ATC
NA
2.4
7.1
57
244
J01DA06
ATC
[U] cefuroxime; systemic
1.6
7.1
201
1342
ZXK00
NOMESCO Finland
Conversion from percutaneous endoscopic to open procedure
5.3
7.1
20
38
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.3
7.1
62
276
C08CA05
ATC
nifedipine; systemic
1.9
7.1
100
544
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
7.1
303
2216
N06AA09
ATC
amitriptyline; systemic
1.7
7.0
138
834
C08CA01
ATC
amlodipine; oral
1.4
7.0
496
3975
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.4
7.0
56
240
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
2.1
6.9
71
339
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
6.9
591
4876
R02
ICPC
Shortness of breath/dyspnoea
1.6
6.9
160
1012
XKD03
NOMESCO Finland
Urethral pressure profilometry
2.8
6.9
41
148
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
6.9
882
7731
K76.9
ICD-10 Finland
Liver disease, unspecified
3.7
6.9
28
77
R03BA01
ATC
beclometasone; inhalant
1.6
6.9
193
1288
A46
ICD-10 Finland
Erysipelas
1.6
6.9
184
1213
Y0599
ICD-8 Finland
Investigation of digestive system
3.4
6.8
31
93
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
6.8
116
675
JJA21
NOMESCO Finland
Laparoscopic biopsy of liver
22.6
6.7
9
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.6
6.6
177
1162
1413
FHL
Laparoscopy and other therapeutic procedure
2.8
6.6
39
140
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.5
6.6
29
85
R12
ICD-10 Finland
Heartburn
1.9
6.6
92
496
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
3.0
6.6
35
118
JAH00
NOMESCO Finland
Laparotomy
2.7
6.6
43
164
R74
ICPC
Upper respiratory infection acute
1.4
6.5
294
2167
J20
ICD-10 Finland
Acute bronchitis
1.7
6.5
124
742
J01FA15
ATC
telithromycin; oral
1.7
6.5
124
745
N05CF01
ATC
zopiclone; oral
1.4
6.5
453
3610
R60.0
ICD-10 Finland
Localized oedema
1.6
6.5
151
958
R11
ICD-10 Finland
Nausea and vomiting
1.8
6.4
104
593
K85.2
ICD-10 Finland
Alcohol-induced acute pancreatitis
70.1
6.4
7
*
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
70.1
6.4
7
*
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.3
6.4
583
4837
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.8
6.4
100
562
J45.1
ICD-10 Finland
Nonallergic asthma
1.8
6.4
96
534
K11.2
ICD-10 Finland
Sialoadenitis
2.7
6.4
41
154
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.4
210
1452
K76.80
ICD-10 Finland
Hepatic cyst
6.0
6.3
16
27
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.5
6.3
230
1626
C10AC01
ATC
colestyramine; oral
2.9
6.3
36
126
JK3BT
NOMESCO Finland
Catherisation of bile duct with X-ray guidance
18.1
6.3
9
5
C23
ICD-10 Finland
Malignant neoplasm of gallbladder
18.1
6.3
9
5
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.8
6.3
108
630
K83.4
ICD-10 Finland
Spasm of sphincter of Oddi
+∞
6.3
6
*
57501
ICD-8 Finland
Cholecystitis and cholangitis, without mention of calculus, Cholecystitis chronica
+∞
6.3
6
*
JK1AT
NOMESCO Finland
Cathetrisation of bile cyst with radiological guidance
+∞
6.3
6
*
JK3MB
NOMESCO Finland
Postoperative cholangiography
+∞
6.3
6
*
JL5CM
NOMESCO Finland
Bile and pancreas ducts extensive MRI examination with 3 Tesla magnet
+∞
6.3
6
*
N02AA05
ATC
oxycodone; systemic
1.5
6.2
203
1401
ZXD20
NOMESCO Finland
Day surgery
1.6
6.2
171
1133
I20.99
ICD-10 Finland
Angina pectoris, unspecified
1.8
6.2
96
538
L03
ICPC
Low back symptom/complaint
1.4
6.2
297
2218
A06AD11
ATC
lactulose; oral
1.5
6.2
208
1445
G44.2
ICD-10 Finland
Tension-type headache
1.6
6.2
160
1045
ZXA00
NOMESCO Finland
Right side
1.4
6.1
379
2958
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.1
6.1
68
339
M79.1
ICD-10 Finland
Myalgia
1.6
6.1
158
1031
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.5
6.1
222
1567
H02AB07
ATC
prednisone; oral
1.5
6.0
198
1368
U01
ICPC
Dysuria/painful urination
1.8
6.0
95
539

Mortality – FinRegistry

↥

Association

Association between endpoint K11_GALLBLAOTH and mortality.

Females

Parameter HR [95% CI] p-value
K11_GALLBLAOTH 1.493 [1.32, 1.69] < 0.001
Birth year 0.991 [0.98, 1.0] 0.034

During the follow-up period (1.1.1998 — 31.12.2019), 860 out of 3457 females with K11_GALLBLAOTH died.

Males

Parameter HR [95% CI] p-value
K11_GALLBLAOTH 1.511 [1.32, 1.74] < 0.001
Birth year 0.989 [0.98, 1.0] 0.022

During the follow-up period (1.1.1998 — 31.12.2019), 816 out of 2490 males with K11_GALLBLAOTH died.

Mortality risk

Mortality risk for people of age

years, who have K11_GALLBLAOTH.

N-year risk Females Males
1 0.177% 0.305%
5 0.953% 1.729%
10 1.97% 4.354%
15 3.672% 8.803%
20 6.419% 14.59%

Relationships between endpoints

↥

Index endpoint: K11_GALLBLAOTH – Other diseases of gallbladder

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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