Premature rupture of membranes

O15_MEMBR_PREMAT_RUPT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O42
  • Hospital discharge: ICD-9 6581A
  • Hospital discharge: ICD-8 63495
  • Cause of death: ICD-10 O42
  • Cause of death: ICD-9 6581A
  • Cause of death: ICD-8 63495

2 out of 7 registries used, show all original rules.

10872

4. Check minimum number of events

None

10872

5. Include endpoints

None

10872

6. Filter based on genotype QC (FinnGen only)

10872

Control definitions (FinnGen only)

Control exclude
O15_MATERN_CARE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O30-O48
Name in latin
Ruptura membranarum fetalium praematura

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 74821 74821 -
Only index persons 74107 74107 -
Unadjusted period prevalence (%)
Whole population 2.14 2.14 -
Only index persons 2.72 2.72 -
Median age at first event (years)
Whole population - 30.02 -
Only index persons - 30.01 -

-FinnGen-

Key figures

All Female Male
Number of individuals 10872 10872 -
Unadjusted period prevalence (%) 3.71 3.71 -
Median age at first event (years) 30.45 30.45 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
8265
Matched controls
64832
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
SPAT1196
SPAT
Monitoring of normal pregnancy
5.7
323.0
1525
2467
O32.1
ICD-10 Finland
Maternal care for breech presentation
381.2
323.0
755
17
O80.0
ICD-10 Finland
Spontaneous vertex delivery
3.2
323.0
4695
18878
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
+∞
323.0
2095
*
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
9.1
323.0
1858
1996
O47.1
ICD-10 Finland
False labour at or after 37 completed weeks of gestation
241.2
323.0
544
19
O80.8
ICD-10 Finland
Other single spontaneous delivery
12.7
323.0
1526
1136
Z39.2
ICD-10 Finland
Routine postpartum follow-up
5.4
323.0
3093
6486
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
17.9
323.0
1937
1087
SPAT1379
SPAT
Health check-up of pregnant person
5.9
323.0
3029
5794
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
5.1
323.0
1653
3032
Z34.9
ICD-10 Finland
Supervision of normal pregnancy, unspecified
3.7
323.0
2138
5641
6581A
ICD-9 Finland
Other problems associated with amniotic cavity and membranes, Premature rupture of membranes
+∞
323.0
765
*
W90
ICPC
Uncompl labour/delivery livebirth
5.7
323.0
1190
1850
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
7.9
323.0
1946
2432
O60
ICD-10 Finland
Preterm labour and delivery
30.0
323.0
1187
360
SPAT1197
SPAT
Extensive health check-up of expecting family
5.5
323.0
3206
6692
63495
ICD-8 Finland
Other complications of pregnancy, Effluxus liquoris amnii praetemporarius
+∞
323.0
514
*
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
3.1
323.0
2410
7543
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
448.8
323.0
537
10
O42.9
ICD-10 Finland
Premature rupture of membranes, unspecified
4503599627370496.0
323.0
4359
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
4.6
323.0
1679
3392
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
4.4
323.0
4498
13749
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
2934.1
323.0
1015
*
O48
ICD-10 Finland
Prolonged pregnancy
2763.1
323.0
346
*
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
4.2
323.0
2968
7670
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
4.2
323.0
2904
7339
SPAT1380
SPAT
Postpartum check-up
5.8
323.0
2572
4685
W78
ICPC
Pregnancy
5.0
323.0
3568
8539
O42.1
ICD-10 Finland
Premature rupture of membranes, onset of labour after 24 hours
+∞
323.0
1374
*
O36.5
ICD-10 Finland
Maternal care for poor fetal growth
406.2
323.0
396
8
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
6.3
323.0
3349
6346
MAX99
NOMESCO Finland
Assistance to normal delivery
3.9
323.0
2022
4953
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
10.4
323.0
1244
1085
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
1415.5
315.1
335
*
O35.8
ICD-10 Finland
Maternal care for other (suspected) fetal abnormality and damage
1390.6
310.3
330
*
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
3.2
300.2
1934
5608
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
3.3
288.1
1766
4917
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
4.8
282.5
1084
1988
Z32.1
ICD-10 Finland
Pregnancy confirmed
3.2
281.5
1776
5042
O46.9
ICD-10 Finland
Antepartum haemorrhage, unspecified
409.7
277.2
303
6
O30.0
ICD-10 Finland
Twin pregnancy
1214.6
275.8
294
*
O41.1
ICD-10 Finland
Infection of amniotic sac and membranes
+∞
272.6
286
*
SPAT1373
SPAT
Combined screening in early pregnancy
10.1
256.4
560
461
W84
ICPC
Pregnancy high risk
6.4
255.7
752
998
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
3.7
249.7
1267
3004
WX307
NOMESCO Finland
Obstetric epidural analgesia
3.2
233.1
1484
4179
MA2XE
NOMESCO Finland
Other obstetric ultrasound examination
3.8
229.9
1114
2527
O35.1
ICD-10 Finland
Maternal care for (suspected) chromosomal abnormality in fetus
+∞
228.5
240
*
SPAT1375
SPAT
Structural ultrasound screening, weeks 18+0-21+6
15.1
226.6
411
224
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
3.1
224.1
1457
4154
O41.0
ICD-10 Finland
Oligohydramnios
642.4
221.3
239
*
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
4.3
215.7
920
1851
O47.9
ICD-10 Finland
False labour, unspecified
18.6
214.8
360
158
O82.0
ICD-10 Finland
Delivery by elective caesarean section
9.0
208.2
486
449
W92
ICPC
Compl labour/ delivery livebirth
9.1
206.4
477
433
SPAT1200
SPAT
Guidance for breast-feeding and breast care
5.8
204.5
646
933
W85
ICPC
Gestational diabetes
4.6
203.7
795
1460
O68.0
ICD-10 Finland
Labour and delivery complicated by fetal heart rate anomaly
4.1
192.5
854
1774
XMA22
NOMESCO Finland
General examination of pregnant woman
3.8
192.1
943
2144
ZXD05
NOMESCO Finland
Urgent procedure
2.2
187.0
2622
11350
SPAT1189
SPAT
Other ultrasound examination during pregnancy
4.8
183.2
686
1202
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
10.2
182.4
395
317
O35.9
ICD-10 Finland
Maternal care for (suspected) fetal abnormality and damage, unspecified
1404.9
171.8
183
*
O99.80
ICD-10 Finland
The fear of childbirth
4.0
169.3
777
1657
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
5.3
168.8
576
908
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
5.1
162.2
570
928
O40
ICD-10 Finland
Polyhydramnios
455.2
156.8
171
*
SPAT1357
SPAT
Monitoring of problem during pregnancy
5.7
156.1
496
716
MAB20
NOMESCO Finland
Failed external version
232.1
154.1
173
6
Z35.0
ICD-10 Finland
Supervision of pregnancy with history of infertility
4.8
152.8
562
961
O81.4
ICD-10 Finland
Vacuum extractor delivery
2.9
145.9
1011
2942
W29
ICPC
Pregnancy symptom/complaint other
5.0
144.9
519
861
O75.6
ICD-10 Finland
Delayed delivery after spontaneous or unspecified rupture of membranes
6.0
144.6
443
610
O42.2
ICD-10 Finland
Premature rupture of membranes, labour delayed by therapy
+∞
144.4
152
*
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
141.0
3588
19039
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
5.1
137.8
485
788
O20.0
ICD-10 Finland
Threatened abortion
5.0
128.5
458
754
MAE00
NOMESCO Finland
Outlet vacuum delivery
2.9
121.7
853
2484
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
3.5
121.6
643
1531
MAA00
NOMESCO Finland
Amniocentesis
7.7
120.2
304
318
WX320
NOMESCO Finland
Spinalanesthesy
2.2
116.7
1375
5318
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
2.9
116.2
815
2372
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
15.2
115.7
208
110
Z87.5
ICD-10 Finland
Personal history of complications of pregnancy, childbirth and the puerperium
15.8
113.6
201
102
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
2.1
111.9
1532
6326
SPAT1195
SPAT
Antenatal classes
3.5
111.1
584
1381
WX306
NOMESCO Finland
Lumbar epidural anesthesy
2.8
108.8
800
2393
MA3AE
NOMESCO Finland
Combined first trimester screening
2.8
106.9
779
2317
O44.0
ICD-10 Finland
Placenta praevia specified as without haemorrhage
308.6
105.8
117
*
O34.3
ICD-10 Finland
Maternal care for cervical incompetence
897.7
105.3
113
*
Z3232
NOMESCO Finland
Midwife
2.2
104.9
1229
4717
O02.1
ICD-10 Finland
Missed abortion
2.7
101.3
783
2410
O63.0
ICD-10 Finland
Prolonged first stage (of labour)
6.1
101.1
300
395
O72.0
ICD-10 Finland
Third-stage haemorrhage
4.5
100.5
397
726
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
5.3
99.7
335
514
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
6.9
98.1
267
312
NE1AG
NOMESCO Finland
MRI pelvimetry with high intensity magnet
93.1
97.3
117
10
MAC40
NOMESCO Finland
Pharmacological induction or advancement of labor
5.7
96.2
301
424
WYA40
NOMESCO Finland
Assessment of oral health and treatment needs for family expecting first child
4.6
96.2
371
662
MAC96
NOMESCO Finland
Other induction or advancement of labour
4.6
94.2
363
647
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
4.8
91.5
333
559
O41.8
ICD-10 Finland
Other specified disorders of amniotic fluid and membranes
+∞
91.1
96
*
Z34
ICD-10 Finland
Supervision of normal pregnancy
2.7
89.8
674
2033
Z39.1
ICD-10 Finland
Care and examination of lactating mother
4.4
89.0
355
655
O30.00
ICD-10 Finland
Twin pregnancy with separate amniotic and chorionic sacs
736.8
86.3
93
*
O84.0
ICD-10 Finland
Multiple delivery, all spontaneous
61.9
86.2
109
14
SPAT1263
SPAT
Sampling
1.6
86.2
3413
19669
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.6
84.6
3380
19493
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
5.4
83.2
272
404
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.7
83.0
657
2043
O03.9
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, without complication
2.7
82.5
627
1902
O44.1
ICD-10 Finland
Placenta praevia with haemorrhage
704.7
82.5
89
*
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
3.4
82.1
434
1026
6440B
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]
6.5
80.9
228
280
O13
ICD-10 Finland
Gestational [pregnancy-induced] hypertension
2.8
79.6
580
1715
O80.1
ICD-10 Finland
Spontaneous breech delivery
16.9
76.9
132
62
O36.9
ICD-10 Finland
Maternal care for fetal problem, unspecified
656.7
76.8
83
*
FM1QE
NOMESCO Finland
Extensive ultrasound of fetal heart
10.6
76.8
161
121
O32.2
ICD-10 Finland
Maternal care for transverse and oblique lie
225.5
75.7
85
*
O21.9
ICD-10 Finland
Vomiting of pregnancy, unspecified
5.1
75.2
257
402
MAG00
NOMESCO Finland
Assisted breech delivery
20.8
73.8
118
45
G03GA01
ATC
chorionic gonadotrophin; parenteral
2.5
72.7
633
2073
O64.0
ICD-10 Finland
Obstructed labour due to incomplete rotation of fetal head
4.2
72.1
302
584
ZXD00
NOMESCO Finland
Emergency procedure
3.9
64.8
296
619
O46.8
ICD-10 Finland
Other antepartum haemorrhage
552.7
64.6
70
*
O28.8
ICD-10 Finland
Other abnormal findings on antenatal screening of mother
6.7
64.4
178
213
MBC10
NOMESCO Finland
Repair of obstetric laceration of vagina
3.7
63.3
308
680
SPAT1190
SPAT
Insertion or removal of intrauterine contraceptive device
2.0
62.8
932
3893
Z36.8
ICD-10 Finland
Other antenatal screening
3.7
61.8
300
661
6441A
ICD-9 Finland
Early or threatened labour, Other threatened labour
+∞
61.6
65
*
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
4.0
61.1
268
541
O36.4
ICD-10 Finland
Maternal care for intrauterine death
+∞
60.7
64
*
WX234
NOMESCO Finland
Paracervical blockade
2.8
60.2
416
1185
O02.0
ICD-10 Finland
Blighted ovum and nonhydatidiform mole
2.8
59.9
428
1247
O41.9
ICD-10 Finland
Disorder of amniotic fluid and membranes, unspecified
+∞
57.8
61
*
W05
ICPC
Pregnancy vomiting/nausea
5.6
57.4
181
258
MAB10
NOMESCO Finland
External version
45.6
56.7
75
13
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
3.8
55.6
253
528
O82.11
ICD-10 Finland
Childbirth with an emergency caesarean section in an emergency
7.1
55.5
146
163
SPAT1301
SPAT
No procedures
1.6
55.0
2113
11741
O34.1
ICD-10 Finland
Maternal care for tumour of corpus uteri
242.6
54.6
61
*
G03GA05
ATC
follitropin alfa; parenteral
2.5
53.9
466
1515
MBA20
NOMESCO Finland
Expression of placenta
8.0
52.1
127
126
Z10.8
ICD-10 Finland
Routine general health check-up of other defined subpopulations
2.5
51.9
453
1479
MAC10
NOMESCO Finland
Antepartum dilatation of cervical canal
3.8
51.2
237
502
O36.3
ICD-10 Finland
Maternal care for signs of fetal hypoxia
+∞
50.2
53
*
Z32.0
ICD-10 Finland
Pregnancy, not (yet) confirmed
2.8
49.8
354
1027
O26.7
ICD-10 Finland
Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
5.5
49.7
158
228
O63.1
ICD-10 Finland
Prolonged second stage (of labour)
2.6
49.5
396
1232
SPAT1383
SPAT
Extensive health check-up at 4 years of age
6.0
49.5
148
198
H01CC01
ATC
ganirelix; parenteral
2.6
49.2
382
1168
Z39.0
ICD-10 Finland
Care and examination immediately after delivery
4.7
49.1
181
309
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
3.8
47.9
223
475
6584B
ICD-9 Finland
Other problems associated with amniotic cavity and membranes, Infection of amniotic cavity[AMNIONITIS, SYNNYTYKSEN AIKANA]
+∞
47.4
50
*
Z37.0
ICD-10 Finland
Single live birth
1.7
47.0
1162
5725
FM1NE
NOMESCO Finland
Ultrasound examination of fetal heart
15.8
47.0
82
41
O61.0
ICD-10 Finland
Failed medical induction of labour
6.4
46.9
132
163
O32.0
ICD-10 Finland
Maternal care for unstable lie
401.2
46.7
51
*
W27
ICPC
Fear of complications of pregnancy
4.8
45.7
164
272
W03
ICPC
Antepartum bleeding
5.6
45.5
143
204
SPAT1310
SPAT
Counselling related to known health issue
1.5
45.2
2346
13812
O84.2
ICD-10 Finland
Multiple delivery, all by caesarean section
63.2
44.7
56
7
W30
ICPC
Pregnancy, Medical examin/health eval complete
6.8
44.6
121
142
O47
ICD-10 Finland
False labour
6.1
44.5
130
169
O28.3
ICD-10 Finland
Abnormal ultrasonic finding on antenatal screening of mother
8.5
44.4
104
97
MA3AE
SPAT
NA
8.2
44.2
106
103
O91.2
ICD-10 Finland
Nonpurulent mastitis associated with childbirth
4.3
43.7
176
329
O45.9
ICD-10 Finland
Premature separation of placenta, unspecified
+∞
43.6
46
*
O84.8
ICD-10 Finland
Other multiple delivery
131.5
43.2
50
*
WX600
NOMESCO Finland
Single shot through catheter
3.7
42.3
200
432
SPAT1391
SPAT
Counselling and guidance related to family situation
3.9
42.2
185
374
O23.5
ICD-10 Finland
Infections of the genital tract in pregnancy
4.9
42.1
149
244
SPAT1315
SPAT
Periodic health check-up of children and adolescents
2.1
42.1
501
1901
TLW12
NOMESCO Finland
Insertion of frozen embryo
3.2
41.9
242
611
SPAT1312
SPAT
General health counselling
1.4
41.8
2537
15346
D82
ICPC
Teeth/gum disease
1.4
41.8
3064
19190
LAA10
NOMESCO Finland
Percutaneous or transvaginal puncture and recovery of oocyte
2.5
41.7
360
1169
O03.4
ICD-10 Finland
Spontaneous abortion, Incomplete, without complication
2.8
41.5
292
842
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
1.5
41.0
1673
9320
O34.0
ICD-10 Finland
Maternal care for congenital malformation of uterus
+∞
40.7
43
*
J01DB01
ATC
cefalexin; oral
1.4
40.1
6399
45688
MA4AT
NOMESCO Finland
Chorion biopsy with ultrasound guidance
33.4
39.3
55
13
SPAT1308
SPAT
Sexual health counselling
1.5
39.1
1965
11425
SPAT1192
SPAT
Gynaecological examination
1.5
39.0
1439
7822
O68.8
ICD-10 Finland
Labour and delivery complicated by other evidence of fetal stress
4.9
38.8
137
224
N61
ICD-10 Finland
Inflammatory disorders of breast
2.5
38.8
332
1071
SPAT1187
SPAT
General ultrasound examination in early pregnancy
4.6
38.5
143
247
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
38.4
2175
12938
Z35.1
ICD-10 Finland
Supervision of pregnancy with history of abortive outcome
8.1
38.3
92
90
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
5.3
38.3
124
184
O03.1
ICD-10 Finland
Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage
3.2
38.3
218
546
SPAT1128
SPAT
Instruction of pelvic floor / sphincter exercises
4.7
37.7
138
235
O24.9
ICD-10 Finland
Diabetes mellitus in pregnancy, unspecified
3.2
37.3
210
521
MBA96
NOMESCO Finland
Other removal of retained products of conception after delivery or abortion
2.8
36.8
250
706
O85
ICD-10 Finland
Puerperal sepsis
4.6
36.7
135
231
W18
ICPC
Post-partum symptom/complaint other
6.9
36.1
96
110
N97.9
ICD-10 Finland
Female infertility, unspecified
1.8
36.1
748
3477
SPAT1381
SPAT
Extensive health check-up at 4 months of age
6.0
35.8
106
141
ZXE00
NOMESCO Finland
One hour or less
1.4
35.7
2676
16695
HMAK
NOMESCO Finland
NA
1.6
35.7
1110
5782
TLW10
NOMESCO Finland
Transfer of fresh embryo
2.8
35.5
241
679
MA5AE
SPAT
NA
6.4
34.8
98
122
SPAT1382
SPAT
Extensive health check-up at 18 months of age
6.1
34.8
101
131
O75.0
ICD-10 Finland
Maternal distress during labour and delivery
3.5
34.8
172
387
MBA40
NOMESCO Finland
Pharmacological evacuation of uterus after abortion
3.0
34.7
215
571
SAD02
NOMESCO Finland
Assessment of need for oral health care, extensive
2.0
34.6
461
1831
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
4.5
34.1
130
231
O61.8
ICD-10 Finland
Other failed induction of labour
14.6
34.1
61
33
R4110
NOMESCO Finland
Physiotherapy
0.6
33.8
754
8927
6582B
ICD-9 Finland
Other problems associated with amniotic cavity and membranes, Delayed delivery after spontaneous or unspecified rupture of membranes
+∞
33.2
35
*
TLW00
NOMESCO Finland
Insemination
2.5
33.1
278
889
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
4.7
32.8
118
198
O20.8
ICD-10 Finland
Other haemorrhage in early pregnancy
6.3
32.6
92
115
O21
ICD-10 Finland
Excessive vomiting in pregnancy
4.3
32.4
128
236
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
2.2
32.0
336
1203
Z35.4
ICD-10 Finland
Supervision of pregnancy with grand multiparity
6.2
31.2
89
113
A02BC01
ATC
omeprazole; systemic
1.5
31.2
1504
8613
O73.0
ICD-10 Finland
Retained placenta without haemorrhage
4.0
30.9
130
255
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
30.6
2440
15285
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
3.3
30.5
162
386
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
4.9
30.4
106
172
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
30.3
1972
11935
O21.0
ICD-10 Finland
Mild hyperemesis gravidarum
4.2
30.2
121
227
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
29.9
2780
17820
W94
ICPC
Puerperal mastitis
4.6
29.6
109
188
N71.0
ICD-10 Finland
Acute inflammatory disease of uterus
2.2
29.5
333
1233
O75.7
ICD-10 Finland
Vaginal delivery following previous caesarean section
30.1
29.5
42
11
O64.8
ICD-10 Finland
Obstructed labour due to other malposition and malpresentation
6.1
29.3
85
111
SPAT1316
SPAT
Extensive health check-up of children and adolescents
2.2
29.0
332
1237
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
2.4
28.9
252
824
MAB00
NOMESCO Finland
Cerclage of cervix of pregnant uterus
250.1
28.8
32
*
W12
ICPC
Contraception intrauterine
1.5
28.5
1334
7580
LGA20
NOMESCO Finland
Sterilisation by constriction of Fallopian tubes
4.5
28.4
107
189
MBA04
NOMESCO Finland
Curettage of uterus after delivery
5.0
28.4
96
151
G03GA06
ATC
follitropin beta; parenteral
2.2
28.2
314
1156
TMW99
NOMESCO Finland
Other minor surgical procedure in obstetrics
4.8
27.9
99
164
O30.01
ICD-10 Finland
Twin pregnancy with a shared chorionic sac and a separate amniotic sac
+∞
27.5
29
*
MBA05
NOMESCO Finland
Curettage of uterus after abortion
3.7
27.3
128
277
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
1.6
27.2
861
4484
N97.0
ICD-10 Finland
Female infertility associated with anovulation
2.2
26.5
288
1047
63494
ICD-8 Finland
Other complications of pregnancy, Insufficientia cervicis
+∞
26.5
28
*
O35.2
ICD-10 Finland
Maternal care for (suspected) hereditary disease in fetus
+∞
26.5
28
*
MAA10
NOMESCO Finland
Biopsy of chorionic villus
9.8
26.3
56
45
H01CA02
ATC
nafarelin; nasal
2.0
26.3
337
1319
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.5
25.8
190
3021
MBC30
NOMESCO Finland
Repair of partial rupture of perineum
2.4
25.8
228
750
Z63.7
ICD-10 Finland
Other stressful life events affecting family and household
2.9
25.6
166
456
6510B
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]
+∞
25.6
27
*
G03GA02
ATC
human menopausal gonadotrophin; parenteral
2.1
25.1
304
1162
O04.9
ICD-10 Finland
Medical abortion, complete or unspecified, without complication
1.5
25.1
1075
5983
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.5
24.9
1050
5824
6500B
ICD-9 Finland
Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]
0.7
24.9
972
10408
R87.5
ICD-10 Finland
Abnormal findings in specimens from female genital organs, abnormal microbiological findings
2.7
24.9
176
512
6450B
ICD-9 Finland
Prolonged pregnancy[GRAVIDITAS PROLANGATA CUM PARTU]
+∞
24.6
26
*
O73.1
ICD-10 Finland
Retained portions of placenta and membranes, without haemorrhage
4.3
24.5
96
177
Z37.2
ICD-10 Finland
Twins, both liveborn
42.0
24.2
32
6
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.3
24.0
4772
33545
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
23.9
5505
39425
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
23.9
1553
9339
Z35
ICD-10 Finland
Supervision of high-risk pregnancy
3.7
23.7
110
237
6510A
ICD-9 Finland
Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]
+∞
23.7
25
*
Z76.0
ICD-10 Finland
Issue of repeat prescription
0.7
23.4
608
7018
G02CB01
ATC
bromocriptine; systemic
2.5
23.4
198
637
SPAT1303
SPAT
Counselling and guidance related to growth and development
3.4
23.0
118
276
N05AX08
ATC
risperidone; systemic
0.4
22.8
134
2295
WZB00
SPAT
NA
0.5
22.8
192
2925
O35.0
ICD-10 Finland
Maternal care for (suspected) central nervous system malformation in fetus
+∞
22.7
24
*
G01AA10
ATC
clindamycin; vaginal
1.4
22.7
1475
8858
Z39
ICD-10 Finland
Postpartum care and examination
3.1
22.4
130
333
W82
ICPC
Abortion spontaneous
3.4
22.3
112
258
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
2.8
22.1
147
413
K02.1
ICD-10 Finland
Caries of dentine
1.3
22.0
4671
32920
Z12
ICPC
Relationship problem with partner
2.5
21.8
183
589
Z30.2
ICD-10 Finland
Sterilization
1.5
21.5
884
4868
ZXA00
NOMESCO Finland
Right side
0.7
21.5
624
7061
SCA03
NOMESCO Finland
Preventive oral health care, extensive
1.8
21.5
411
1860
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
5.2
21.2
69
105
WX230
NOMESCO Finland
Plexus blockade of nervus pudendus
2.7
21.2
152
446
SPAT1262
SPAT
Handing over of treatment supplies
1.5
21.0
690
3617
L02BG04
ATC
letrozole; oral
1.7
20.9
457
2152
Z31.5
ICD-10 Finland
Genetic counselling
1.7
20.5
419
1932
SPAT1188
SPAT
Monitoring of foetal growth
5.5
20.3
63
91
F20.9
ICD-10 Finland
Schizophrenia, unspecified
0.2
19.8
14
682
O33.9
ICD-10 Finland
Maternal care for disproportion, unspecified
173.0
19.5
22
*
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
3.8
19.4
87
183
N05AH03
ATC
olanzapine; systemic
0.5
19.4
162
2475
O10.0
ICD-10 Finland
Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium
2.5
19.4
158
500
WX322
NOMESCO Finland
Combined spinal-epidural analgesia in obstetrics
2.2
19.4
204
734
O14.9
ICD-10 Finland
Pre-eclampsia, unspecified
2.7
19.1
133
385
O34.4
ICD-10 Finland
Maternal care for other abnormalities of cervix
+∞
18.9
20
*
O33.5
ICD-10 Finland
Maternal care for disproportion due to unusually large fetus
+∞
18.9
20
*
O45.8
ICD-10 Finland
Other premature separation of placenta
+∞
18.9
20
*
O34.9
ICD-10 Finland
Maternal care for abnormality of pelvic organ, unspecified
+∞
18.9
20
*
SPAT1393
SPAT
Guidance to support interaction between parent and child
4.1
18.7
75
143
W31
ICPC
Pregnancy, Medical examin/health eval partial
2.4
18.7
171
576
O03
ICD-10 Finland
Spontaneous abortion
3.9
18.4
78
157
F29
ICD-10 Finland
Unspecified nonorganic psychosis
0.4
18.1
94
1681
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
18.1
4551
32338
Z3226
NOMESCO Finland
Physiotherapist
0.7
17.9
538
6059
SPAT1260
SPAT
Consultation of another employee
1.4
17.8
1029
6035
O26.6
ICD-10 Finland
Liver disorders in pregnancy, childbirth and the puerperium
2.4
17.6
151
493
SPAT1307
SPAT
Psychosocial counselling and guidance
1.5
17.6
661
3566
LA2AE
NOMESCO Finland
Ultrasound examination of ovarian cyst
1.9
17.5
266
1112
ZXD10
NOMESCO Finland
Scheduled procedure
0.8
17.4
1528
14662
O62.0
ICD-10 Finland
Primary inadequate contractions
5.5
17.3
53
76
SPAT1283
SPAT
Restricted health certificate
1.3
17.2
2067
13488
ZXA05
NOMESCO Finland
Left side
0.7
17.2
612
6691
SPAT1153
SPAT
Removal of sutures
1.3
17.2
1521
9532
P01AB01
ATC
metronidazole; oral, rectal
1.2
17.2
2939
19991
SPAT1281
SPAT
Other administrative function
1.6
17.1
493
2501
O34.8
ICD-10 Finland
Maternal care for other abnormalities of pelvic organs
+∞
17.0
18
*
W99
ICPC
Disorder of pregn/delivery other
5.8
17.0
50
68
N05AH02
ATC
clozapine; systemic
0.2
17.0
24
773
N05AX12
ATC
aripiprazole; systemic
0.5
17.0
132
2063
SPAT1273
SPAT
Structured assessment of psychoactive substance / tobacco use
1.7
16.8
342
1577
O24
ICD-10 Finland
Diabetes mellitus in pregnancy
5.3
16.8
53
79
G02BA03
ATC
plastic IUD with progestogen
1.3
16.8
1428
8900
Z31.2
ICD-10 Finland
In vitrofertilization
2.9
16.7
107
295
O00.9
ICD-10 Finland
Ectopic pregnancy, unspecified
2.6
16.7
128
391
8811
FHL
Cesarean section
1.7
16.7
374
1776
MAA96
NOMESCO Finland
Other intrauterine operation on pregnant uterus or fetus
6.7
16.7
44
52
O03.0
ICD-10 Finland
Spontaneous abortion, Incomplete, complicated by genital tract and pelvic infection
3.6
16.5
76
165
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
16.4
5796
42461
J01CA08
ATC
pivmecillinam; oral
1.2
16.4
3733
26130
SPAT1388
SPAT
Extensive health check-up based on individual need
4.7
16.4
57
95
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.3
16.3
1918
12472
G03DA04
ATC
progesterone; systemic, rectal, vaginal
1.8
16.3
298
1330
W28
ICPC
Limited function/disability (W)
7.7
16.2
39
40
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
0.2
16.2
14
601
O69.0
ICD-10 Finland
Labour and delivery complicated by prolapse of cord
11.6
16.1
31
21
SPAT1193
SPAT
Pap smear
1.3
16.0
1240
7614
SPAT1389
SPAT
Visit based on need for special support
1.9
16.0
250
1060
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.3
15.9
1682
10783
Z31.1
ICD-10 Finland
Artificial insemination
3.6
15.8
74
163
Z82.7
ICD-10 Finland
Family history of congenital malformations, deformations and chromosomal abnormalities
4.9
15.8
53
85
OAA12
SPAT
NA
2.1
15.7
185
703
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
15.6
4069
28815
SPAT1325
SPAT
Vaccination
1.3
15.5
1665
10696
A78
ICPC
Infectious disease other/NOS
2.2
15.4
164
594
O83.0
ICD-10 Finland
Breech extraction
15.7
15.4
26
13
N97.4
ICD-10 Finland
Female infertility associated with male factors
1.9
15.2
221
911
6584A
ICD-9 Finland
Other problems associated with amniotic cavity and membranes, Infection of amniotic cavity[AMNIONITIS, RASKAUDEN AIKANA]
+∞
15.2
16
*
6418A
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Other antepartum haemorrhage[ALIA HAEMORRHAGIA IN GRAVIDITATE,HOITOJ ENNEN SYNN]
+∞
15.2
16
*
O32.8
ICD-10 Finland
Maternal care for other malpresentation of fetus
+∞
15.2
16
*
SPAT1384
SPAT
Extensive health check-up on first grade
3.7
15.1
69
149
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
2.1
15.1
178
676
Z01.2
ICD-10 Finland
Dental examination
1.2
15.0
3226
22376
SPAT1238
SPAT
Brief therapy
2.0
14.8
198
790
MBC33
NOMESCO Finland
Repair of complete rupture of perineum
3.3
14.7
77
186
O69.1
ICD-10 Finland
Labour and delivery complicated by cord around neck, with compression
4.1
14.6
58
111
LCH11
NOMESCO Finland
Pharmacologic abortion
1.5
14.5
506
2690
O03.6
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, complicated by delayed or excessive haemorrhage
3.1
14.3
81
206
C08CA05
ATC
nifedipine; systemic
1.9
14.3
220
926
MAW96
NOMESCO Finland
Other operation in pregnancy or at delivery
4.0
14.3
59
117
O43.8
ICD-10 Finland
Other placental disorders
+∞
14.2
15
*
O36.0
ICD-10 Finland
Maternal care for rhesus isoimmunization
+∞
14.2
15
*
Z29
ICPC
Social problem NOS
2.3
14.1
128
433
O24.1
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent
4.4
14.1
52
93
N96
ICD-10 Finland
Habitual aborter
2.9
14.0
86
233
6440A
ICD-9 Finland
Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS IMMINENS]
2.2
13.9
149
544
O66.5
ICD-10 Finland
Failed application of vacuum extractor and forceps, unspecified
5.7
13.9
41
57
Z86.4
ICD-10 Finland
Personal history of psychoactive substance abuse
4.6
13.8
49
84
WX110
SPAT
NA
0.5
13.8
120
1812
SPAT1392
SPAT
Counselling and guidance related to couple relationship
2.8
13.8
89
248
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
13.7
4074
29064
O26.9
ICD-10 Finland
Pregnancy-related condition, unspecified
4.1
13.7
55
107
O62.3
ICD-10 Finland
Precipitate labour
7.4
13.6
33
35
LGA10
NOMESCO Finland
Sterilisation by destruction or division of Fallopian tubes
3.5
13.4
63
140
G03DB01
ATC
dydrogesterone; oral
1.3
13.4
1283
8104
L02AE02
ATC
leuprorelin; implant, parenteral
2.0
13.3
178
711
6419A
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Unspecified antepartum haemorrhage[HAEMORRHAGIA NUD IN GRAVIDITATE,HOITOJ ENN SYNN NUD]
+∞
13.3
14
*
LGA00
NOMESCO Finland
Sterilisation by ligature of Fallopian tubes
4.4
13.2
49
88
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
0.5
13.2
129
1879
O28.0
ICD-10 Finland
Abnormal haematological finding on antenatal screening of mother
10.8
13.2
26
19
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
1.5
13.1
427
2232
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
13.1
236
1053
MAE20
NOMESCO Finland
Failed vacuum delivery
6.4
13.1
35
43
N02BE01
ATC
paracetamol; systemic, rectal
1.2
13.0
6194
46051
E66.01
ICD-10 Finland
Obesity due to excess calories
1.4
12.8
610
3453
LC2HE
NOMESCO Finland
Hystero-salpingography with ultrasound
1.5
12.8
492
2668
NE1MA
NOMESCO Finland
Birth channel measurement with X-ray
28.3
12.8
18
5
WYA50
NOMESCO Finland
Student oral health check consistent with decree to assess need for oral health guidance and services
0.5
12.8
139
1964
EB1AA
SPAT
NA
0.5
12.7
116
1724
P25
ICPC
Phase of life problem adult
1.6
12.7
365
1856
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
0.5
12.6
107
1624
M01AE01
ATC
ibuprofen; systemic, rectal
1.3
12.6
7332
55624
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.5
12.5
470
2539
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
12.5
3686
26188
-31
ICPC
Medical examin/health eval partial
1.6
12.4
366
1874
O35.5
ICD-10 Finland
Maternal care for (suspected) damage to fetus by drugs
+∞
12.3
13
*
O31.2
ICD-10 Finland
Continuing pregnancy after intrauterine death of one fetus or more
+∞
12.3
13
*
6412B
ICD-9 Finland
Antepartum haemorrhage, abruptio placentae and placenta praevia, Premature separation of placenta[ABLATIO PLACENTAE ANTETEMPUS,SYNN PÄÄTT HOITOJAKSO]
+∞
12.3
13
*
L03
ICPC
Low back symptom/complaint
1.2
12.1
1547
10112
J01CA04
ATC
amoxicillin; systemic
1.2
12.0
6632
49769
N05AH04
ATC
quetiapine; oral
0.8
12.0
831
8260
O00.1
ICD-10 Finland
Tubal pregnancy
1.9
12.0
172
710
MBC20
NOMESCO Finland
Repair of obstetric laceration of vulva
3.3
12.0
62
150
ZXE20
NOMESCO Finland
More than three and less than five hours
0.7
11.8
288
3375
O86.8
ICD-10 Finland
Other specified puerperal infections
4.6
11.7
41
70
O70.0
ICD-10 Finland
First degree perineal laceration during delivery
2.4
11.7
97
314
A98
ICPC
Health maint/preventive medicine
1.6
11.7
8055
62188
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
0.6
11.7
209
2612
N97.8
ICD-10 Finland
Female infertility of other origin
1.7
11.6
221
1002
O75.3
ICD-10 Finland
Other infection during labour
7.3
11.6
28
30
O12.0
ICD-10 Finland
Gestational oedema
3.7
11.5
51
109
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
0.5
11.5
116
1677
O42
ICD-10 Finland
Premature rupture of membranes
+∞
11.4
12
*
O33.4
ICD-10 Finland
Maternal care for disproportion of mixed maternal and fetal origin
+∞
11.4
12
*
O36
ICD-10 Finland
Maternal care for other known or suspected fetal problems
55.1
11.3
14
*
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
0.2
11.2
14
481
Z16
ICPC
Relationship problem with child
3.8
11.2
48
100
O14.0
ICD-10 Finland
Mild to moderate pre-eclampsia
2.0
11.2
140
548
P72
ICPC
Schizophrenia
0.3
11.1
20
564
K04.0
ICD-10 Finland
Pulpitis
1.3
11.1
767
4621
ZXD20
NOMESCO Finland
Day surgery
0.7
10.9
442
4745
Z09.8
ICD-10 Finland
Follow-up examination after other treatment for other conditions
1.7
10.9
247
1182
R4120
NOMESCO Finland
Occupational therapy
0.6
10.9
128
1771
JN3AD
NOMESCO Finland
Abdominal CT examination
1.6
10.9
296
1487
O23.1
ICD-10 Finland
Infections of bladder in pregnancy
4.7
10.8
37
62
R21
ICPC
Throat symptom/complaint
1.2
10.8
1867
12581
WX610
NOMESCO Finland
Patient controlled analgesia
3.3
10.6
53
126
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
2.1
10.6
121
459
O70.2
ICD-10 Finland
Third degree perineal laceration during delivery
3.0
10.6
62
165
XF400
NOMESCO Finland
ECG with 12 standard connections
0.7
10.5
282
3244
N05AA02
ATC
levomepromazine; systemic
0.5
10.4
62
1054
O33.1
ICD-10 Finland
Maternal care for disproportion due to generally contracted pelvis
+∞
10.4
11
*
O33.3
ICD-10 Finland
Maternal care for disproportion due to outlet contraction of pelvis
+∞
10.4
11
*
6545A
ICD-9 Finland
Abnormality of organs and soft tissues of pelvis, Cervical incompetence[INSUFFICIENTIA CERVICIS UTERI, RASKAUDEN AIKANA]
+∞
10.4
11
*
SPAT1240
SPAT
Therapeutic discussion
1.3
10.4
984
6192
O80.9
ICD-10 Finland
Single spontaneous delivery, unspecified
2.2
10.3
105
378
R09
ICPC
Sinus symptom/complaint
1.4
10.3
632
3738
R01AD12
ATC
fluticasone furoate; nasal
1.2
10.3
2503
17397
R51.80
ICD-10 Finland
Headache
1.3
10.1
1090
6967
O68.1
ICD-10 Finland
Labour and delivery complicated by meconium in amniotic fluid
3.1
10.1
57
146
LGA22
NOMESCO Finland
Hysteroscopic sterilisation
2.0
10.1
132
527
O99.5
ICD-10 Finland
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
2.9
10.1
62
169
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
10.0
969
6110
O69.8
ICD-10 Finland
Labour and delivery complicated by other cord complications
14.8
10.0
17
9
O04.6
ICD-10 Finland
Medical abortion, complete or unspecified, complicated by delayed or excessive haemorrhage
2.0
9.9
120
464
SGA01
NOMESCO Finland
Tooth opening as first aid
1.3
9.9
1149
7409
W17
ICPC
Post-partum bleeding
6.8
9.9
25
29
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.2
9.9
1663
11163
-48
ICPC
Clarification/discussion RFE/demand
1.6
9.8
239
1166
N39.3
ICD-10 Finland
Stress incontinence
1.5
9.8
370
2002
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
1.8
9.8
169
746
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
0.4
9.8
47
857
ULC02
NOMESCO Finland
Hysteroscopy
1.5
9.8
356
1913
B01AB05
ATC
enoxaparin; parenteral
1.2
9.7
1293
8464
O86.4
ICD-10 Finland
Pyrexia of unknown origin following delivery
3.8
9.7
41
85
O28.1
ICD-10 Finland
Abnormal biochemical finding on antenatal screening of mother
3.1
9.7
55
142
WX810
NOMESCO Finland
Neonatal intesive care
7.0
9.7
24
27
O68.9
ICD-10 Finland
Labour and delivery complicated by fetal stress, unspecified
6.2
9.7
26
33
WZC00
SPAT
NA
0.6
9.6
124
1673
WX290
NOMESCO Finland
Other blockade of nerve
1.2
9.6
3806
27474
O20
ICD-10 Finland
Haemorrhage in early pregnancy
4.1
9.6
37
71
63497
ICD-8 Finland
Other complications of pregnancy, Partus prematurus imminens, alibi non classificabilis
2.2
9.5
97
351
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.3
9.5
718
4382
OAB38
SPAT
NA
0.4
9.5
28
622
R3110
NOMESCO Finland
Psychosocial training
2.0
9.5
119
469
O36.2
ICD-10 Finland
Maternal care for hydrops fetalis
+∞
9.5
10
*
6570A
ICD-9 Finland
Polyhydramnios[POLYHYDRAMNION, RASKAUDEN AIKANA]
+∞
9.5
10
*
O43.0
ICD-10 Finland
Placental transfusion syndromes
+∞
9.5
10
*
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
0.7
9.4
395
4212
N05AB03
ATC
perphenazine; systemic, rectal
0.5
9.4
72
1122
TLW14
NOMESCO Finland
ICSI
2.3
9.4
83
281
EB1SA
SPAT
NA
0.6
9.4
111
1533
MA2BG
NOMESCO Finland
Fetal examination with high intensity magnet
86.4
9.4
11
*
W01
ICPC
Question of pregnancy
2.1
9.4
107
406
N71.9
ICD-10 Finland
Inflammatory disease of uterus, unspecified
2.5
9.4
71
222
Z30.5
ICD-10 Finland
Surveillance of (intrauterine) contraceptive device
1.3
9.4
728
4462
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
0.5
9.3
82
1229
C10AA01
ATC
simvastatin; oral
0.8
9.3
526
5375
OAA11
SPAT
NA
1.5
9.3
301
1578
SAB02
NOMESCO Finland
Oral and dental health check by dental hygienist or dental assistant
1.4
9.3
494
2851
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.4
9.3
471
2698
O62.1
ICD-10 Finland
Secondary uterine inertia
2.5
9.3
73
233
J03.9
ICD-10 Finland
Acute tonsillitis, unspecified
1.4
9.2
461
2635
LCD00
NOMESCO Finland
Hysterectomy
0.5
9.2
97
1380
N04AA02
ATC
biperiden; systemic
0.3
9.1
19
496
Z37.1
ICD-10 Finland
Single stillbirth
25.5
9.1
13
*
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
0.4
9.1
28
611
KAY40
NOMESCO Finland
NA
0.6
9.1
158
1988
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
0.6
9.1
143
1837
F34.1
ICD-10 Finland
Dysthymia
0.6
9.0
112
1523
O69.2
ICD-10 Finland
Labour and delivery complicated by other cord entanglement, with compression
7.5
9.0
21
22
O65.4
ICD-10 Finland
Obstructed labour due to fetopelvic disproportion, unspecified
3.7
8.9
38
80
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
0.5
8.9
76
1149
O28.9
ICD-10 Finland
Abnormal finding on antenatal screening of mother, unspecified
8.8
8.9
19
17
O66.2
ICD-10 Finland
Obstructed labour due to unusually large fetus
6.1
8.9
24
31
A11JC
ATC
Vitamins, other combinations
31.4
8.8
12
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
0.2
8.8
6
297
N06AX11
ATC
mirtazapine; oral
0.8
8.8
1555
14046
J01CE02
ATC
phenoxymethylpenicillin; oral
1.2
8.8
5579
41574
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
0.5
8.8
59
956
O03.5
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, complicated by genital tract and pelvic infection
4.8
8.7
29
48
Z36.4
ICD-10 Finland
Antenatal screening for fetal growth retardation using ultrasound and other physical methods
2.0
8.7
113
451
WX290
SPAT
NA
0.5
8.7
70
1075
EMB10
NOMESCO Finland
Tonsillectomy
1.3
8.7
565
3373
LAA06
NOMESCO Finland
Transvaginal puncture of ovarian cyst
2.4
8.6
72
237
SPAT1374
SPAT
Serum screening during second trimester
20.4
8.6
13
5
O04.1
ICD-10 Finland
Medical abortion, incomplete, complicated by delayed or excessive haemorrhage
2.2
8.6
83
294
O66.0
ICD-10 Finland
Obstructed labour due to shoulder dystocia
3.8
8.6
36
75
N76.0
ICD-10 Finland
Acute vaginitis
1.3
8.6
662
4050
N05CF01
ATC
zopiclone; oral
0.8
8.6
1155
10692
O83.1
ICD-10 Finland
Other assisted breech delivery
13.1
8.5
15
9
MAB03
NOMESCO Finland
Removal of cerclage of cervix uteri before childbirth
+∞
8.5
9
*
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
0.5
8.5
70
1066
O30.1
ICD-10 Finland
Triplet pregnancy
78.5
8.5
10
*
O83.8
ICD-10 Finland
Other specified assisted single delivery
4.3
8.5
31
57
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
0.6
8.5
114
1519
Z2221
NOMESCO Finland
Medical doctor
0.8
8.5
1379
12550
MBW96
NOMESCO Finland
Other operation after delivery or abortion
4.6
8.4
29
50
IHZ02
SPAT
NA
0.3
8.4
20
489
Z36.9
ICD-10 Finland
Antenatal screening, unspecified
1.9
8.4
129
550
O62.2
ICD-10 Finland
Other uterine inertia
3.6
8.4
37
81
O71.4
ICD-10 Finland
Obstetric high vaginal laceration
2.5
8.3
63
196
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.4
8.3
466
2717
N03AG01
ATC
valproic acid; systemic, rectal
0.6
8.3
181
2166
I10
ICD-10 Finland
Essential (primary) hypertension
0.8
8.3
1287
11764
G03GB02
ATC
clomifene; oral
1.6
8.2
201
986
N81.6
ICD-10 Finland
Rectocele
1.5
8.2
265
1391
O68.3
ICD-10 Finland
Labour and delivery complicated by biochemical evidence of fetal stress
2.8
8.1
52
148
O12.1
ICD-10 Finland
Gestational proteinuria
2.6
8.1
59
181
D73
ICPC
Gastroenteritis presumed infection
1.5
8.1
260
1363
Z3231
NOMESCO Finland
Registered nurse
0.8
8.1
1048
9743
O64.3
ICD-10 Finland
Obstructed labour due to brow presentation
6.3
8.1
21
26
N05BA06
ATC
lorazepam; systemic, sublingual
0.5
8.0
78
1134
R01AD08
ATC
fluticasone; nasal
1.2
8.0
2053
14271
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
0.6
8.0
141
1763
XMA20
NOMESCO Finland
Early examination of pregnancy
1.9
8.0
107
434
-30
ICPC
Medical examin/health eval complete
1.5
8.0
242
1252
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
0.4
8.0
36
669
R75
ICPC
Sinusitis acute/chronic
1.4
7.9
324
1785
Z18
ICPC
Illness problem with child
3.8
7.9
33
69
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
0.3
7.9
20
475
MAC00
NOMESCO Finland
Rupture of amniotic membrane
3.7
7.9
34
73
Z32
ICD-10 Finland
Pregnancy examination and test
2.2
7.9
80
290
N05BA01
ATC
diazepam; systemic, rectal
0.7
7.8
395
4102
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
1.5
7.8
236
1221
W64
ICPC
Pregnancy, Encounter/prob initiated by provider
18.8
7.8
12
5
SGC00
NOMESCO Finland
Local medication of root channels of tooth
1.3
7.8
724
4542
63230
ICD-8 Finland
Haemorrhage of pregnancy, Threatened abortion
2.1
7.8
86
322
G03GA09
ATC
corifollitropin alfa; parenteral
2.8
7.8
50
143
N06AX16
ATC
venlafaxine; oral
0.8
7.7
763
7290
O23.4
ICD-10 Finland
Unspecified infection of urinary tract in pregnancy
5.6
7.7
22
31
F43.00
ICD-10 Finland
Acute stress reaction mild
1.6
7.7
211
1066
O75.2
ICD-10 Finland
Pyrexia during labour, not elsewhere classified
4.2
7.6
28
52
N81.1
ICD-10 Finland
Cystocele
1.5
7.6
235
1219
EBA00
SPAT
NA
0.4
7.6
25
530
O33.2
ICD-10 Finland
Maternal care for disproportion due to inlet contraction of pelvis
+∞
7.6
8
*
8702
FHL
Placement of Cerglagen during pregnancy
70.7
7.6
9
*
O31.1
ICD-10 Finland
Continuing pregnancy after abortion of one fetus or more
70.7
7.6
9
*
SPAT1385
SPAT
Extensive health check-up on fifth grade
2.8
7.6
46
128
SPAT1387
SPAT
Health survey during first study year, university level
0.5
7.5
45
757
RD211
NOMESCO Finland
NA
1.5
7.5
217
1112
J01DA01
ATC
[U] cefalexin; systemic
1.1
7.5
4417
32547
R72
ICPC
Strep throat
2.1
7.5
84
319
Q51.3
ICD-10 Finland
Bicornate uterus
3.9
7.5
30
61
-67
ICPC
Referral to physician/hospital
3.0
7.5
42
109
O66.4
ICD-10 Finland
Failed trial of labour, unspecified
11.0
7.4
14
10
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.3
7.4
469
2790
D25.1
ICD-10 Finland
Intramural leiomyoma of uterus
0.7
7.4
207
2363
WGA11
SPAT
NA
0.2
7.4
5
246
TMA00
NOMESCO Finland
Episiotomy
1.4
7.4
293
1606
SPAT1322
SPAT
Pre-employment physical examination
1.6
7.4
170
823
O21.1
ICD-10 Finland
Hyperemesis gravidarum with metabolic disturbance
3.4
7.4
35
82
O67.9
ICD-10 Finland
Intrapartum haemorrhage, unspecified
3.5
7.3
33
74
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.3
7.3
552
3371
Z09.9
ICD-10 Finland
Follow-up examination after unspecified treatment for other conditions
2.1
7.3
78
290
205
Kela drug reimbursment
Chronic hypertension
0.7
7.3
291
3125
O23.0
ICD-10 Finland
Infections of kidney in pregnancy
4.9
7.2
23
37
ZYC02
SPAT
NA
0.5
7.2
61
918
SPAT1097
SPAT
Recording of ECG
1.3
7.2
460
2740
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
1.6
7.1
176
868
WX110
NOMESCO Finland
Local anesthesy
1.1
7.1
5306
39632
P22
ICPC
Child behaviour symptom/complaint
3.6
7.1
31
68
SDA02
NOMESCO Finland
Parodonthologic therapy
1.2
7.1
2325
16449
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
1.7
7.0
140
650
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
1.7
7.0
140
650
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.8
7.0
595
5784
SPAT1359
SPAT
Use of symptom diary
1.8
7.0
108
464
-35
ICPC
Urine test
1.8
7.0
113
493
A23
ICPC
Risk factor NOS
1.3
7.0
580
3586
LCH13
NOMESCO Finland
Vacuum aspiration from uterus after medically induced abortion
1.7
7.0
148
701
ZXY49
NOMESCO Finland
Other health care provider
0.1
7.0
*
203
C03CA01
ATC
furosemide; systemic
0.7
6.9
335
3496
J01
ICD-10 Finland
Acute sinusitis
1.4
6.9
354
2035
L02AE01
ATC
buserelin; implant, nasal, parenteral
1.8
6.9
114
500
O02.9
ICD-10 Finland
Abnormal product of conception, unspecified
3.0
6.9
39
102
K02.0
ICD-10 Finland
Caries limited to enamel
1.2
6.9
1170
7837
N88.3
ICD-10 Finland
Incompetence of cervix uteri
35.3
6.9
9
*
MCA00
NOMESCO Finland
Upper uterine segment caesarean section
9.2
6.8
14
12
F20
ICD-10 Finland
Schizophrenia
0.0
6.8
*
162
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.2
6.8
2177
15357
Z97.5
ICD-10 Finland
Presence of (intrauterine) contraceptive device
1.7
6.8
131
603
N03AX09
ATC
lamotrigine; oral
0.7
6.8
224
2480
SXA20
NOMESCO Finland
Local application of medicine to mouth
1.3
6.8
462
2784
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.2
6.7
1691
11721
O70.21
ICD-10 Finland
III degree perineal tear involving less than one half of external anal sphincter thickness torn during childbirth
3.5
6.7
30
68
Q51.2
ICD-10 Finland
Other doubling of uterus
3.6
6.6
29
64
O34.6
ICD-10 Finland
Maternal care for abnormality of vagina
+∞
6.6
7
*
O32.9
ICD-10 Finland
Maternal care for malpresentation of fetus, unspecified
+∞
6.6
7
*
O43.2
ICD-10 Finland
Morbidly adherent placenta
+∞
6.6
7
*
O35.4
ICD-10 Finland
Maternal care for (suspected) damage to fetus from alcohol
+∞
6.6
7
*
O43.9
ICD-10 Finland
Placental disorder, unspecified
+∞
6.6
7
*
O31.8
ICD-10 Finland
Other complications specific to multiple gestation
+∞
6.6
7
*
WZA10
SPAT
NA
0.4
6.6
20
436
N05AF05
ATC
zuclopenthixol; systemic
0.2
6.6
5
230
F20.09
ICD-10 Finland
Paranoid schizophrenia UNS
0.2
6.6
5
231
M54.5
ICD-10 Finland
Low back pain
1.1
6.6
2157
15240
O03.8
ICD-10 Finland
Spontaneous abortion, Complete or unspecified, with other and unspecified complications
4.0
6.6
25
49
O90.8
ICD-10 Finland
Other complications of the puerperium, not elsewhere classified
4.0
6.6
25
49
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.2
6.6
1902
13319
LCH00
NOMESCO Finland
Vacuum aspiration of products of conception from uterus
1.4
6.5
269
1489
MCA96
NOMESCO Finland
Other caesarean section
7.4
6.5
15
16
F20.0
ICD-10 Finland
Paranoid schizophrenia
0.1
6.5
*
155
XLA00
NOMESCO Finland
NA
2.9
6.5
38
104
JAF10
NOMESCO Finland
Repair of umbilical hernia
2.0
6.4
79
314
SGC10
NOMESCO Finland
Covering pulpa of tooth
1.2
6.4
701
4485
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
1.4
6.4
280
1565
XLA10
NOMESCO Finland
NA
1.4
6.4
332
1917
N03AE01
ATC
clonazepam; systemic
0.6
6.3
135
1621
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.2
6.3
848
5548
TQW30
NOMESCO Finland
Acupuncture
2.4
6.3
52
173
6400A
ICD-9 Finland
Haemorrhage in early pregnancy, Threatened abortion
2.1
6.3
71
270
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
0.5
6.3
45
713
ZY010
NOMESCO Finland
Hospital outpatient
0.7
6.3
202
2246
SPAT1182
SPAT
Ultrasound examination of uterus, appendages and lower abdomen
1.8
6.3
107
475
ZX080
NOMESCO Finland
Image guided radiotherapy
1.8
6.3
100
436
A05AA02
ATC
ursodeoxycholic acid; oral
1.8
6.3
94
401
WX100
NOMESCO Finland
Conjunctival surface anesthesia
0.5
6.3
60
872
Z19
ICPC
Loss/death of child problem
6.9
6.3
15
17
W79
ICPC
Unwanted pregnancy
1.6
6.3
171
867
N05AF03
ATC
chlorprothixene; systemic
0.5
6.2
61
879
-2
ICD-10 Finland
NA
0.6
6.2
103
1303
N77.1*B37.3
ICD-10 Finland
Candidiasis of vulva and vagina
1.5
6.2
175
895
TLW20
NOMESCO Finland
Medical ovulation induction
3.6
6.2
26
56
ICB02
NOMESCO Finland
Psychiatric treatment plan, extended/prolonged
0.4
6.1
18
398
IER01
NOMESCO Finland
Psychoeducation, group
0.2
6.1
7
248
OAB36
SPAT
NA
0.4
6.1
28
515
C10AA05
ATC
atorvastatin; oral
0.8
6.1
587
5624
Z36.2
ICD-10 Finland
Other antenatal screening based on amniocentesis
4.3
6.0
21
38
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.1
6.0
2087
14785
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.3
6.0
505
3132
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
0.6
6.0
124
1494

Mortality – FinRegistry

Association

Association between endpoint O15_MEMBR_PREMAT_RUPT and mortality.

Females

Parameter HR [95% CI] p-value
O15_MEMBR_PREMAT_RUPT 0.562 [0.47, 0.67] < 0.001
Birth year 0.994 [0.99, 1.0] 0.164

During the follow-up period (1.1.1998 — 31.12.2019), 264 out of 58310 females with O15_MEMBR_PREMAT_RUPT died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_MEMBR_PREMAT_RUPT.

N-year risk Females Males
1 0.059% No data
5 0.306% No data
10 0.776% No data
15 1.459% No data
20 2.687% No data

Relationships between endpoints

Index endpoint: O15_MEMBR_PREMAT_RUPT – Premature rupture of membranes

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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