Risteys · O15_POOR

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O36.5 Hospital discharge: ICD-9 — 6565A\|6565B Cause of death: ICD-10 — O36.5 Cause of death: ICD-9 — 6565A\|6565B 2 out of 7 registries used, show all original rules.	5571
4. Check minimum number of events None	5571
5. Include endpoints None	5571
6. Filter based on genotype QC (FinnGen only)	5571

	All	Female	Male
Number of individuals
Whole population	42702	42702	-
Only index persons	42233	42233	-
Unadjusted period prevalence (%)
Whole population	1.22	1.22	-
Only index persons	1.55	1.55	-
Median age at first event (years)
Whole population	-	29.46	-
Only index persons	-	29.43	-

	All	Female	Male
Number of individuals	5571	5571	-
Unadjusted period prevalence (%)	1.90	1.90	-
Median age at first event (years)	30.18	30.18	-

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
4833: Matched controls
48329

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O36.5

ICD-10 Finland

Maternal care for poor fetal growth

14773.6

323.0

4191

6565A

ICD-9 Finland

Other foetal and placental problems affecting management of mother, Poor foetal growth[SIKIÖN HIDASTUNUT INTRAUTERIININ KASVU,RASK AIK]

+∞

323.0

449

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

3.7

292.4

1637

5919

Z35.8

ICD-10 Finland

Supervision of other high-risk pregnancies

3.6

287.4

1631

5947

6565B

ICD-9 Finland

Other foetal and placental problems affecting management of mother, Poor foetal growth[SIKIÖN HIDASTUNUT INTRAUTERIININ KASVU,SYNN AIK]

+∞

274.6

261

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

2.7

213.5

2287

12220

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

2.9

209.0

1625

7116

O41.0

ICD-10 Finland

Oligohydramnios

6.6

184.5

510

852

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

2.3

163.1

2882

18935

O13

ICD-10 Finland

Gestational [pregnancy-induced] hypertension

3.5

149.2

799

2602

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

2.2

143.2

2121

12535

SPAT1379

SPAT

Health check-up of pregnant person

2.3

131.3

1677

9142

Z39.2

ICD-10 Finland

Routine postpartum follow-up

2.1

119.8

1838

10776

SPAT1197

SPAT

Extensive health check-up of expecting family

2.1

114.0

1843

10988

SPAT1380

SPAT

Postpartum check-up

2.2

111.6

1437

7736

W78

ICPC

Pregnancy

2.0

107.2

1997

12526

O68.0

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly

2.8

101.7

761

3058

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

2.2

98.3

1178

6070

XMA22

NOMESCO Finland

General examination of pregnant woman

2.5

96.3

844

3707

O80.0

ICD-10 Finland

Spontaneous vertex delivery

1.9

94.0

2789

20382

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

2.5

92.6

822

3626

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

2.5

92.4

819

3612

O32.1

ICD-10 Finland

Maternal care for breech presentation

2.8

91.4

648

2506

Z35.2

ICD-10 Finland

Supervision of pregnancy with other poor reproductive or obstetric history

4.0

89.0

378

992

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

1.9

83.7

1758

11230

O80.8

ICD-10 Finland

Other single spontaneous delivery

2.6

81.8

672

2823

MA2XE

NOMESCO Finland

Other obstetric ultrasound examination

2.2

74.7

873

4372

Z32.1

ICD-10 Finland

Pregnancy confirmed

2.0

74.2

1259

7364

W84

ICPC

Pregnancy high risk

2.7

73.8

554

2202

O14.1

ICD-10 Finland

Severe pre-eclampsia

6.4

70.0

191

307

O60

ICD-10 Finland

Preterm labour and delivery

3.2

68.9

401

1347

O10.0

ICD-10 Finland

Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium

3.9

64.2

279

744

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

1.8

59.6

1277

8000

O82.0

ICD-10 Finland

Delivery by elective caesarean section

2.4

59.6

573

2589

SPAT1196

SPAT

Monitoring of normal pregnancy

2.0

59.2

957

5426

SPAT1317

SPAT

Planned health check-up monitoring, health check-up performed based on individual need

1.9

57.4

1100

6623

MAC10

NOMESCO Finland

Antepartum dilatation of cervical canal

2.9

57.1

366

1310

Z36.0

ICD-10 Finland

Antenatal screening for chromosomal anomalies

2.2

57.1

658

3241

O35.8

ICD-10 Finland

Maternal care for other (suspected) fetal abnormality and damage

3.4

56.6

298

929

Z35.9

ICD-10 Finland

Supervision of high-risk pregnancy, unspecified

2.6

56.3

443

1798

MAA00

NOMESCO Finland

Amniocentesis

3.1

54.3

318

1070

O14.0

ICD-10 Finland

Mild to moderate pre-eclampsia

3.3

50.9

270

846

8811

FHL

Cesarean section

2.7

48.9

364

1425

O14.9

ICD-10 Finland

Pre-eclampsia, unspecified

3.7

48.0

220

613

WX320

NOMESCO Finland

Spinalanesthesy

1.8

47.7

962

5842

MA1AE

NOMESCO Finland

Ultrasound examination of early pregnancy (before 12. postmenstrual week)

1.7

45.3

1187

7793

MAC96

NOMESCO Finland

Other induction or advancement of labour

2.5

43.5

356

1472

Z87.5

ICD-10 Finland

Personal history of complications of pregnancy, childbirth and the puerperium

4.0

40.8

169

432

MAX99

NOMESCO Finland

Assistance to normal delivery

1.7

40.2

1104

7305

C07AG01

ATC

labetalol; systemic

4.2

38.7

152

370

W90

ICPC

Uncompl labour/delivery livebirth

2.0

37.9

563

3045

O28.8

ICD-10 Finland

Other abnormal findings on antenatal screening of mother

3.5

34.2

164

476

O35.1

ICD-10 Finland

Maternal care for (suspected) chromosomal abnormality in fetus

2.7

34.0

246

945

O30.0

ICD-10 Finland

Twin pregnancy

2.9

33.8

213

752

O99.80

ICD-10 Finland

The fear of childbirth

1.9

33.2

577

3293

MAC01

NOMESCO Finland

Rupture of aminiotic membrane for induction of labor

2.6

32.5

246

971

O99.3

ICD-10 Finland

Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium

2.6

31.3

244

980

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

2.5

30.7

255

1060

Z34.0

ICD-10 Finland

Supervision of normal first pregnancy

1.5

30.6

1369

10090

W92

ICPC

Compl labour/ delivery livebirth

2.4

30.1

279

1226

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

1.6

29.5

978

6720

MAC40

NOMESCO Finland

Pharmacological induction or advancement of labor

2.5

28.9

233

953

SPAT1249

SPAT

Treatment-related counselling outside office

1.4

28.3

1973

15826

O36.8

ICD-10 Finland

Maternal care for other specified fetal problems

2.6

27.6

205

801

O20.0

ICD-10 Finland

Threatened abortion

2.2

27.0

276

1271

O20.9

ICD-10 Finland

Haemorrhage in early pregnancy, unspecified

2.1

27.0

324

1606

SPAT1399

SPAT

Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.

1.8

26.5

480

2771

Z35.4

ICD-10 Finland

Supervision of pregnancy with grand multiparity

4.1

26.5

104

255

O35.9

ICD-10 Finland

Maternal care for (suspected) fetal abnormality and damage, unspecified

3.2

25.6

138

440

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

1.6

25.5

707

4623

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

1.5

25.5

881

6086

SPAT1263

SPAT

Sampling

1.4

25.3

1981

16111

SPAT1357

SPAT

Monitoring of problem during pregnancy

2.0

25.3

341

1770

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

1.5

25.3

865

5963

O36.3

ICD-10 Finland

Maternal care for signs of fetal hypoxia

4.2

24.9

227

SPAT1189

SPAT

Other ultrasound examination during pregnancy

1.9

24.9

378

2052

O02.1

ICD-10 Finland

Missed abortion

1.7

23.7

532

3277

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

2.4

23.6

205

871

MA3AE

NOMESCO Finland

Combined first trimester screening

1.7

23.1

489

2960

MA5AE

NOMESCO Finland

Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation

1.7

23.0

494

3001

SPAT1301

SPAT

No procedures

1.4

22.8

1236

9367

6563B

ICD-9 Finland

Other foetal and placental problems affecting management of mother, Foetal distress[ASPHYXIA FOETALIS, SYNNYTYKSEN AIKANA]

3.1

22.2

124

406

O30.00

ICD-10 Finland

Twin pregnancy with separate amniotic and chorionic sacs

4.6

21.8

171

Z36.4

ICD-10 Finland

Antenatal screening for fetal growth retardation using ultrasound and other physical methods

2.5

21.7

172

698

FM1QE

NOMESCO Finland

Extensive ultrasound of fetal heart

3.4

21.5

104

307

C08CA05

ATC

nifedipine; systemic

2.3

21.0

204

918

O36.4

ICD-10 Finland

Maternal care for intrauterine death

4.2

20.8

189

W29

ICPC

Pregnancy symptom/complaint other

2.0

20.8

294

1553

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

1.7

20.0

446

2738

O35.6

ICD-10 Finland

Maternal care for (suspected) damage to fetus by radiation

73.8

19.7

WX306

NOMESCO Finland

Lumbar epidural anesthesy

1.6

19.6

612

4106

Z35.7

ICD-10 Finland

Supervision of high-risk pregnancy due to social problems

5.4

19.4

108

O82.11

ICD-10 Finland

Childbirth with an emergency caesarean section in an emergency

2.7

19.4

133

499

FM1NE

NOMESCO Finland

Ultrasound examination of fetal heart

4.1

19.4

188

O47.1

ICD-10 Finland

False labour at or after 37 completed weeks of gestation

1.8

19.3

369

2161

6563A

ICD-9 Finland

Other foetal and placental problems affecting management of mother, Foetal distress[ASPHYXIA FOETALIS, RASKAUDEN AIKANA]

11.7

19.2

O43.8

ICD-10 Finland

Other placental disorders

11.7

19.2

O47.9

ICD-10 Finland

False labour, unspecified

2.3

19.1

186

838

WX307

NOMESCO Finland

Obstetric epidural analgesia

1.4

18.4

861

6299

O99.1

ICD-10 Finland

Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium

3.2

18.4

312

Z39.1

ICD-10 Finland

Care and examination of lactating mother

2.1

18.1

221

1103

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.4

18.1

1431

11478

O99.4

ICD-10 Finland

Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium

3.5

18.0

237

O03.9

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, without complication

1.7

17.4

397

2452

O72.2

ICD-10 Finland

Delayed and secondary postpartum haemorrhage

2.2

16.6

170

788

O26.82

ICD-10 Finland

Exhaustion and fatigue pregnancy-related

2.0

16.6

213

1084

O28.3

ICD-10 Finland

Abnormal ultrasonic finding on antenatal screening of mother

3.1

16.4

299

6423A

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Transient hypertension of pregnancy[HYPERTENSIO GRAVIDARUM, ENNEN SYNNYTYSTÄ]

3.6

16.3

209

O46.9

ICD-10 Finland

Antepartum haemorrhage, unspecified

2.1

16.2

181

870

6425A

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Severe pre-eclampsia[PRAE-ECLAMPSIA GRAVIS, ENNEN SYNNYTYSTÄ]

7.6

16.1

6424A

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Mild or unspecified pre-eclampsia[PRAE-ECLAMPSIA LEVIS, ENNEN SYNNYTYSTÄ]

3.7

16.0

187

6420X

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Benign essential hypertension complicating pregnancy, childbirth and the puerperium

6.6

15.8

6440B

ICD-9 Finland

Early or threatened labour, Threatened premature labour[PARTUS PRAEMATURUS]

3.2

15.8

269

Z39.0

ICD-10 Finland

Care and examination immediately after delivery

2.5

15.8

128

530

MBA03

NOMESCO Finland

Curettage of uterus after delivery or abortion

1.8

15.7

254

1408

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

1.3

15.4

2007

17198

O04.9

ICD-10 Finland

Medical abortion, complete or unspecified, without complication

1.4

15.2

801

5971

WX290

NOMESCO Finland

Other blockade of nerve

1.3

15.0

2460

21670

O68.8

ICD-10 Finland

Labour and delivery complicated by other evidence of fetal stress

2.7

15.0

102

382

O02.0

ICD-10 Finland

Blighted ovum and nonhydatidiform mole

1.8

14.7

277

1615

O26.88

ICD-10 Finland

Other specified pregnancy-related conditions

2.2

14.2

152

718

O30.01

ICD-10 Finland

Twin pregnancy with a shared chorionic sac and a separate amniotic sac

6.8

14.2

O84.0

ICD-10 Finland

Multiple delivery, all spontaneous

3.2

14.1

235

SGA01

NOMESCO Finland

Tooth opening as first aid

1.4

14.0

803

6073

O99.6

ICD-10 Finland

Diseases of the digestive system complicating pregnancy, childbirth and the puerperium

2.6

14.0

100

387

Z30.2

ICD-10 Finland

Sterilization

1.4

13.9

615

4434

Z72.0

ICD-10 Finland

Tobacco use

2.4

13.9

115

480

K02.1

ICD-10 Finland

Caries of dentine

1.3

13.7

2863

25854

SPAT1200

SPAT

Guidance for breast-feeding and breast care

1.7

13.6

285

1720

SPAT1246

SPAT

Screening of depression or other psychiatric problem

1.6

13.5

380

2477

O42.9

ICD-10 Finland

Premature rupture of membranes, unspecified

1.6

13.1

312

1947

O35.5

ICD-10 Finland

Maternal care for (suspected) damage to fetus by drugs

5.8

13.1

O99.0

ICD-10 Finland

Anaemia complicating pregnancy, childbirth and the puerperium

2.4

13.1

108

453

O45.9

ICD-10 Finland

Premature separation of placenta, unspecified

4.5

13.1

100

B01AB05

ATC

enoxaparin; parenteral

1.3

12.8

873

6784

WX234

NOMESCO Finland

Paracervical blockade

1.7

12.7

272

1648

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.3

12.7

1709

14590

O64.1

ICD-10 Finland

Obstructed labour due to breech presentation

2.1

12.6

149

738

O16

ICD-10 Finland

Unspecified maternal hypertension

3.7

12.6

143

6580A

ICD-9 Finland

Other problems associated with amniotic cavity and membranes, Oligohydramnios[OLIGOHYDRAMNION, RASKAUDEN AIKANA]

11.0

12.5

MBA00

NOMESCO Finland

Vacuum aspiration from uterus after delivery or abortion

1.9

12.4

187

1016

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.2

12.4

2503

22379

SPAT1315

SPAT

Periodic health check-up of children and adolescents

1.6

12.3

320

2048

SPAT1310

SPAT

Counselling related to known health issue

1.3

12.3

1269

10459

SPAT1307

SPAT

Psychosocial counselling and guidance

1.5

12.2

435

2998

G02CB01

ATC

bromocriptine; systemic

2.1

12.2

138

669

MAA10

NOMESCO Finland

Biopsy of chorionic villus

4.1

11.8

111

SPAT1312

SPAT

General health counselling

1.3

11.8

1424

11968

J01CA08

ATC

pivmecillinam; oral

1.2

11.5

2305

20514

O03.4

ICD-10 Finland

Spontaneous abortion, Incomplete, without complication

1.8

11.4

199

1137

Z35.0

ICD-10 Finland

Supervision of pregnancy with history of infertility

1.6

11.4

262

1624

O21.9

ICD-10 Finland

Vomiting of pregnancy, unspecified

2.0

11.3

138

693

SAA01

NOMESCO Finland

Simple examination of mouth

1.3

11.2

3505

32735

O84.2

ICD-10 Finland

Multiple delivery, all by caesarean section

3.2

11.2

174

V230A

ICD-9 Finland

Supervision of high-risk pregnancy, Pregnancy with history of infertility

3.2

11.2

185

N71.0

ICD-10 Finland

Acute inflammatory disease of uterus

1.7

11.2

237

1436

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.2

11.1

2289

20407

SPAT1391

SPAT

Counselling and guidance related to family situation

2.1

11.0

116

550

MAG00

NOMESCO Finland

Assisted breech delivery

2.8

10.9

242

P01AB01

ATC

metronidazole; oral, rectal

1.2

10.8

1827

15929

Z37.0

ICD-10 Finland

Single live birth

1.3

10.7

908

7270

O80.1

ICD-10 Finland

Spontaneous breech delivery

2.5

10.6

316

O44.0

ICD-10 Finland

Placenta praevia specified as without haemorrhage

2.4

10.6

353

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.3

10.5

1216

10136

N02BE01

ATC

paracetamol; systemic, rectal

1.3

10.4

3714

35020

SPAT1240

SPAT

Therapeutic discussion

1.4

10.4

658

5042

O10.9

ICD-10 Finland

Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium

4.7

10.2

O20.8

ICD-10 Finland

Other haemorrhage in early pregnancy

2.8

10.1

234

SPAT1260

SPAT

Consultation of another employee

1.4

10.1

628

4802

N07BA03

ATC

varenicline; oral

1.7

10.0

217

1322

O99.5

ICD-10 Finland

Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium

2.5

10.0

301

Z31.5

ICD-10 Finland

Genetic counselling

1.5

10.0

318

2139

Z32.0

ICD-10 Finland

Pregnancy, not (yet) confirmed

1.6

9.9

231

1437

SPAT1153

SPAT

Removal of sutures

1.3

9.9

885

7128

Z37.2

ICD-10 Finland

Twins, both liveborn

3.6

9.9

116

WX110

NOMESCO Finland

Local anesthesy

1.2

9.7

3251

30281

A02BC01

ATC

omeprazole; systemic

1.3

9.7

892

7213

J01DB01

ATC

cefalexin; oral

1.3

9.7

3755

35534

O36.9

ICD-10 Finland

Maternal care for fetal problem, unspecified

2.2

9.7

444

XMA20

NOMESCO Finland

Early examination of pregnancy

2.0

9.7

113

561

O34.3

ICD-10 Finland

Maternal care for cervical incompetence

2.8

9.6

207

Z86.4

ICD-10 Finland

Personal history of psychoactive substance abuse

3.4

9.4

126

SPAT1272

SPAT

Drug screening

4.1

9.4

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.3

9.3

860

6953

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.3

9.2

1047

8694

O03.1

ICD-10 Finland

Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage

1.9

9.1

138

754

C07AB02

ATC

metoprolol; systemic

1.5

9.1

342

2385

MAC98

NOMESCO Finland

Other induction of labor

6.5

8.9

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.2

8.9

2753

25314

SPAT1190

SPAT

Insertion or removal of intrauterine contraceptive device

1.3

8.9

552

4214

MBA30

NOMESCO Finland

Manual removal of placenta from delivered uterus

1.8

8.8

141

787

K04.0

ICD-10 Finland

Pulpitis

1.4

8.8

515

3896

Z35

ICD-10 Finland

Supervision of high-risk pregnancy

2.1

8.7

474

SPAT1373

SPAT

Combined screening in early pregnancy

1.7

8.7

172

1023

SAA02

NOMESCO Finland

Basic examination of mouth

1.2

8.6

3274

30664

O03.6

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, complicated by delayed or excessive haemorrhage

2.4

8.5

290

Z32

ICD-10 Finland

Pregnancy examination and test

2.2

8.5

395

MBC10

NOMESCO Finland

Repair of obstetric laceration of vagina

1.7

8.5

165

978

SPAT1192

SPAT

Gynaecological examination

1.3

8.5

877

7185

O26.7

ICD-10 Finland

Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium

2.0

8.5

100

501

J01DA01

ATC

[U] cefalexin; systemic

1.2

8.4

2732

25170

Z36.5

ICD-10 Finland

Antenatal screening for isoimmunization

12.8

8.4

Z34

ICD-10 Finland

Supervision of normal pregnancy

1.4

8.3

430

3181

WYA40

NOMESCO Finland

Assessment of oral health and treatment needs for family expecting first child

1.7

8.3

162

963

SPAT1283

SPAT

Restricted health certificate

1.2

8.3

1299

11159

O44.1

ICD-10 Finland

Placenta praevia with haemorrhage

2.5

8.3

252

6425B

ICD-9 Finland

Hypertension complicating pregnancy, childbirth and the puerperium, Severe pre-eclampsia[PRAE-ECLAMPSIA GRAVIS, SYNNYTYKSEN AIKANA]

5.5

8.3

O34.0

ICD-10 Finland

Maternal care for congenital malformation of uterus

3.1

8.2

135

6510A

ICD-9 Finland

Multiple gestation, Twin pregnancy[GEMINI, RASKAUDEN AIKANA]

4.4

8.2

LGA10

NOMESCO Finland

Sterilisation by destruction or division of Fallopian tubes

2.3

8.1

307

MAB20

NOMESCO Finland

Failed external version

1.9

8.1

113

602

WZB00

SPAT

0.6

8.0

107

1804

SPAT1303

SPAT

Counselling and guidance related to growth and development

2.1

8.0

388

W03

ICPC

Antepartum bleeding

2.2

7.9

356

6522B

ICD-9 Finland

Malposition and malpresentation of foetus, Breech presentation without mention of version[PRAESENTATIO CLUNIUM,SYNNYTYKSEN AIKANA]

2.1

7.9

390

MAC02

NOMESCO Finland

Rupture of aminiotic membrane for advancement of labor

2.7

7.9

190

Z35.6

ICD-10 Finland

Supervision of very young primigravida

3.9

7.8

MBA20

NOMESCO Finland

Expression of placenta

2.3

7.6

308

R51.80

ICD-10 Finland

Headache

1.3

7.6

727

5894

O61.0

ICD-10 Finland

Failed medical induction of labour

2.0

7.5

465

O34.1

ICD-10 Finland

Maternal care for tumour of corpus uteri

2.7

7.5

177

NE1AG

NOMESCO Finland

MRI pelvimetry with high intensity magnet

2.2

7.5

325

Z29

ICPC

Social problem NOS

1.9

7.5

512

O00.1

ICD-10 Finland

Tubal pregnancy

1.7

7.4

136

794

MA4AT

NOMESCO Finland

Chorion biopsy with ultrasound guidance

2.4

7.4

260

O04.6

ICD-10 Finland

Medical abortion, complete or unspecified, complicated by delayed or excessive haemorrhage

1.9

7.3

497

MAB10

NOMESCO Finland

External version

2.3

7.2

277

W27

ICPC

Fear of complications of pregnancy

1.9

7.2

506

SPAT1309

SPAT

Guidance related to psychoactive substances / risk behaviour

1.8

7.1

113

630

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.2

7.0

2432

22368

W05

ICPC

Pregnancy vomiting/nausea

2.0

7.0

425

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.2

7.0

1001

8496

O28.0

ICD-10 Finland

Abnormal haematological finding on antenatal screening of mother

4.0

6.9

H66.0

ICD-10 Finland

Acute suppurative otitis media

1.4

6.9

307

2213

O73.1

ICD-10 Finland

Retained portions of placenta and membranes, without haemorrhage

2.3

6.9

269

W99

ICPC

Disorder of pregn/delivery other

2.8

6.9

153

D68.8

ICD-10 Finland

Other specified coagulation defects

2.3

6.9

249

N30.9

ICD-10 Finland

Cystitis, unspecified

1.5

6.8

207

1385

O43.9

ICD-10 Finland

Placental disorder, unspecified

9.3

6.8

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

1.4

6.7

350

2595

O81.4

ICD-10 Finland

Vacuum extractor delivery

1.3

6.7

499

3909

P19

ICPC

Drug abuse

2.6

6.7

184

F17.29

ICD-10 Finland

Addiction caused by tobacco UNS

2.2

6.6

295

O69.8

ICD-10 Finland

Labour and delivery complicated by other cord complications

5.9

6.6

O45.8

ICD-10 Finland

Other premature separation of placenta

4.2

6.6

Z12

ICPC

Relationship problem with partner

1.7

6.6

121

709

O31.8

ICD-10 Finland

Other complications specific to multiple gestation

12.2

6.6

G03DA04

ATC

progesterone; systemic, rectal, vaginal

1.6

6.5

167

1073

WYA30

NOMESCO Finland

Preparations for expected poor cooperation

1.4

6.5

342

2544

Z82.7

ICD-10 Finland

Family history of congenital malformations, deformations and chromosomal abnormalities

2.8

6.5

142

O21.1

ICD-10 Finland

Hyperemesis gravidarum with metabolic disturbance

2.9

6.4

128

R2110

NOMESCO Finland

Giving the first information

1.4

6.4

365

2746

6412B

ICD-9 Finland

Antepartum haemorrhage, abruptio placentae and placenta praevia, Premature separation of placenta[ABLATIO PLACENTAE ANTETEMPUS,SYNN PÄÄTT HOITOJAKSO]

5.7

6.4

KAY40

NOMESCO Finland

0.5

6.4

1177

65000

ICD-8 Finland

Delivery without mention of complication, Occipital presentation

0.7

6.4

177

2556

G03GB02

ATC

clomifene; oral

1.7

6.4

126

755

SPAT1383

SPAT

Extensive health check-up at 4 years of age

1.9

6.3

465

M54.5

ICD-10 Finland

Low back pain

1.2

6.3

1358

11969

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

1.3

6.3

447

3481

O85

ICD-10 Finland

Puerperal sepsis

1.9

6.3

414

TMW99

NOMESCO Finland

Other minor surgical procedure in obstetrics

1.9

6.3

414

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

1.3

6.3

397

3043

O73.0

ICD-10 Finland

Retained placenta without haemorrhage

2.0

6.2

377

SGC10

NOMESCO Finland

Covering pulpa of tooth

1.3

6.1

484

3827

PEF23

NOMESCO Finland

Thrombendarterectomy of femoral artery

12.5

6.1

W79

ICPC

Unwanted pregnancy

1.6

6.1

135

837

D25.9

ICD-10 Finland

Leiomyoma of uterus, unspecified

0.7

6.1

186

2637

O62.3

ICD-10 Finland

Precipitate labour

3.7

6.1

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

2.1

6.0

290

MBA96

NOMESCO Finland

Other removal of retained products of conception after delivery or abortion

1.6

6.0

152

974

NAME	O15_POOR_FETGRO
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O365
HD_ICD_9	6565A\|6565B
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O365
COD_ICD_9	6565A\|6565B
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
O15_POOR_FETGRO	1.13 [0.96, 1.34]	0.154
Birth year	0.994 [0.99, 1.0]	0.179

N-year risk	Females	Males
1	0.141%	No data
5	0.614%	No data
10	1.52%	No data
15	3.059%	No data
20	5.523%	No data

Poor fetal growth

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints