Postpartum haemorrhage due to retained placenta

O15_POSTPART_HAEMORRH_PLACENTA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O72.0
  • Hospital discharge: ICD-9 6660
  • Cause of death: ICD-10 O72.0
  • Cause of death: ICD-9 6660

2 out of 7 registries used, show all original rules.

5523

4. Check minimum number of events

None

5523

5. Include endpoints

None

5523

6. Filter based on genotype QC (FinnGen only)

5523

Control definitions (FinnGen only)

Control exclude
!(NUMBER_OF_OFFSPRING>0), !(O15_DELIVERY, O15_DELIVERY_PROXY)

Extra metadata

First used in FinnGen datafreeze
DF8

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37145 37145 -
Only index persons 36716 36716 -
Unadjusted period prevalence (%)
Whole population 1.06 1.06 -
Only index persons 1.35 1.35 -
Median age at first event (years)
Whole population - 30.09 -
Only index persons - 30.08 -

-FinnGen-

Key figures

All Female Male
Number of individuals 5523 5523 -
Unadjusted period prevalence (%) 1.88 1.88 -
Median age at first event (years) 30.45 30.45 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
4955
Matched controls
49550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
30.8
323.0
1182
499
6660B
ICD-9 Finland
Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM CUM RETENT PLAC TOTALI]
+∞
323.0
421
*
6660C
ICD-9 Finland
Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM CUM RETENT PLAC PARTIALI]
+∞
323.0
448
*
6660A
ICD-9 Finland
Postpartum haemorrhage, Third-stage haemorrhage[HAEMORRHAGIA POST PARTUM STADII III]
+∞
323.0
1020
*
O72.0
ICD-10 Finland
Third-stage haemorrhage
16384.0
323.0
3130
*
8832
FHL
Manual placenta removal and associated scraping
23.9
230.4
335
150
8831
FHL
Uterine exploration and / or scraping or suction emptying (ad 24 hours)
23.1
165.1
242
110
MBA04
NOMESCO Finland
Curettage of uterus after delivery
13.9
147.5
261
198
MBA03
NOMESCO Finland
Curettage of uterus after delivery or abortion
3.7
115.4
546
1586
8841
FHL
Uterine emptying and scraping (ad 6 weeks)
18.0
104.7
166
95
O72.1
ICD-10 Finland
Other immediate postpartum haemorrhage
3.6
100.8
489
1443
WW500
NOMESCO Finland
Blood transfusion
5.0
81.2
276
579
MBC30
NOMESCO Finland
Repair of partial rupture of perineum
3.5
74.7
373
1119
O72.2
ICD-10 Finland
Delayed and secondary postpartum haemorrhage
3.9
72.3
314
837
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.2
60.5
686
3355
MBC20
NOMESCO Finland
Repair of obstetric laceration of vulva
7.6
55.8
134
180
O73.0
ICD-10 Finland
Retained placenta without haemorrhage
4.7
51.3
182
399
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
2.6
51.3
400
1610
O73.1
ICD-10 Finland
Retained portions of placenta and membranes, without haemorrhage
4.0
31.8
132
339
MBC00
NOMESCO Finland
Repair of obstetric laceration of cervix uteri
8.9
27.6
59
67
O71.3
ICD-10 Finland
Obstetric laceration of cervix
9.1
27.1
57
63
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.6
25.8
362
6015
MBB10
NOMESCO Finland
Packing of delivered uterus
14.8
24.7
41
28
MBC10
NOMESCO Finland
Repair of obstetric laceration of vagina
2.2
23.6
243
1124
MAX99
NOMESCO Finland
Assistance to normal delivery
1.4
21.4
1084
8080
WX600
NOMESCO Finland
Single shot through catheter
2.3
21.0
207
938
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
1.4
19.5
977
7248
MBA00
NOMESCO Finland
Vacuum aspiration from uterus after delivery or abortion
2.0
18.7
234
1179
6671A
ICD-9 Finland
Retained placenta or membranes, without haemorrhage, Retained portions of placenta or membranes, without haemorrhage
4.5
18.1
64
144
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
0.7
17.7
642
8791
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.9
16.8
105
373
O70.0
ICD-10 Finland
First degree perineal laceration during delivery
2.6
16.5
122
478
8834
FHL
Kerviksrupure repair
13.6
15.9
27
20
SPAT1197
SPAT
Extensive health check-up of expecting family
1.3
15.4
1530
12615
MBA96
NOMESCO Finland
Other removal of retained products of conception after delivery or abortion
1.9
15.2
211
1109
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
1.3
14.9
1671
13996
W92
ICPC
Compl labour/ delivery livebirth
1.8
14.4
254
1450
Z39.2
ICD-10 Finland
Routine postpartum follow-up
1.3
14.3
1513
12559
8502
FHL
Evacuation and abrasion
1.7
14.0
321
1981
W85
ICPC
Gestational diabetes
1.5
13.8
442
2971
Z35.2
ICD-10 Finland
Supervision of pregnancy with other poor reproductive or obstetric history
1.9
13.1
208
1146
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
1.7
12.9
296
1831
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
1.3
12.9
1561
13142
O48
ICD-10 Finland
Prolonged pregnancy
1.6
12.8
354
2301
W78
ICPC
Pregnancy
1.3
12.4
1668
14212
O82.0
ICD-10 Finland
Delivery by elective caesarean section
0.6
12.4
208
3334
O81.4
ICD-10 Finland
Vacuum extractor delivery
1.4
12.0
609
4499
6653B
ICD-9 Finland
Other obstetrical trauma, Laceration of cervix
7.2
12.0
28
39
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
0.7
11.8
305
4465
Z39.1
ICD-10 Finland
Care and examination of lactating mother
1.7
11.7
220
1285
SPAT1380
SPAT
Postpartum check-up
1.3
11.6
1158
9483
8839
FHL
Other measure in this category
15.0
11.3
18
12
SPAT1379
SPAT
Health check-up of pregnant person
1.3
10.9
1319
11058
B01AB05
ATC
enoxaparin; parenteral
1.3
10.9
974
7857
MAE00
NOMESCO Finland
Outlet vacuum delivery
1.4
10.7
521
3816
MBB96
NOMESCO Finland
Other manual procedure on delivered uterus
23.4
10.2
14
6
8801
FHL
Suction cup delivery
1.9
10.2
156
854
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
1.2
10.0
1649
14297
2800A
ICD-9 Finland
Iron deficiency anaemias, Secondary to blood loss (chronic)
6.8
9.6
23
34
SPAT1246
SPAT
Screening of depression or other psychiatric problem
1.4
9.3
376
2660
H01CC01
ATC
ganirelix; parenteral
1.7
9.2
196
1194
6482A
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Anaemia
4.4
9.1
31
70
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
9.0
959
7886
MBA10
NOMESCO Finland
Manual exploration of delivered uterus
12.5
8.9
15
12
TMA00
NOMESCO Finland
Episiotomy
1.5
8.8
319
2207
6670A
ICD-9 Finland
Retained placenta or membranes, without haemorrhage, Retained placenta without haemorrhage
3.1
8.5
44
142
G02AB01
ATC
methylergometrine; systemic
2.7
8.5
54
199
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
1.3
8.4
860
7031
O85
ICD-10 Finland
Puerperal sepsis
2.1
8.4
94
458
PC7NT
NOMESCO Finland
Endovascular occlusion of uteral arteries to stop puerperal bleeding
7.8
8.3
18
23
N81.2
ICD-10 Finland
Incomplete uterovaginal prolapse
1.6
8.3
189
1170
O42.0
ICD-10 Finland
Premature rupture of membranes, onset of labour within 24 hours
1.7
8.3
177
1075
O20.0
ICD-10 Finland
Threatened abortion
1.5
8.3
239
1573
O44.1
ICD-10 Finland
Placenta praevia with haemorrhage
2.4
8.1
64
268
8833
FHL
Correction of II ^ 0 or III ^ 0 perineumrupth or vaginal rupture
3.1
8.0
41
132
MBC33
NOMESCO Finland
Repair of complete rupture of perineum
2.3
8.0
71
314
SPAT1375
SPAT
Structural ultrasound screening, weeks 18+0-21+6
1.8
7.9
133
754
MAC96
NOMESCO Finland
Other induction or advancement of labour
1.5
7.9
244
1633
O36.6
ICD-10 Finland
Maternal care for excessive fetal growth
1.4
7.9
338
2420
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.3
7.7
848
6991
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
1.3
7.7
895
7424
N81.1
ICD-10 Finland
Cystocele
1.6
7.6
213
1394
A10AE04
ATC
insulin glargine; parenteral
0.5
7.5
72
1326
G03GA05
ATC
follitropin alfa; parenteral
1.5
7.5
230
1536
O63.1
ICD-10 Finland
Prolonged second stage (of labour)
1.5
7.5
268
1854
SPAT1373
SPAT
Combined screening in early pregnancy
1.6
7.5
196
1261
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
0.5
7.4
51
1040
O99.80
ICD-10 Finland
The fear of childbirth
1.3
7.4
501
3875
Z10.8
ICD-10 Finland
Routine general health check-up of other defined subpopulations
1.6
7.2
182
1164
O36.8
ICD-10 Finland
Maternal care for other specified fetal problems
1.6
7.2
159
980
WX306
NOMESCO Finland
Lumbar epidural anesthesy
1.3
7.1
560
4418
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.2
7.1
1986
17941
6748X
ICD-9 Finland
Other and unspecified complications of the puerperium, not elsewhere classified, Other
3.5
7.1
31
90
O44.0
ICD-10 Finland
Placenta praevia specified as without haemorrhage
2.1
7.0
79
388
6641B
ICD-9 Finland
Trauma to perineum and vulva during delivery, Second-degree perineal laceration
4.0
6.9
25
62
6400A
ICD-9 Finland
Haemorrhage in early pregnancy, Threatened abortion
2.0
6.8
80
402
6611B
ICD-9 Finland
Abnormality of forces of labour, Secondary uterine inertia
2.0
6.8
84
429
O03.1
ICD-10 Finland
Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage
1.7
6.8
137
826
N81.6
ICD-10 Finland
Rectocele
1.5
6.8
246
1706
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
0.6
6.7
70
1257
O02.1
ICD-10 Finland
Missed abortion
1.3
6.6
462
3586
W90
ICPC
Uncompl labour/delivery livebirth
1.3
6.6
489
3831
C03CA01
ATC
furosemide; systemic
0.7
6.6
173
2525
ULC02
NOMESCO Finland
Hysteroscopy
1.4
6.6
259
1828
O41.8
ICD-10 Finland
Other specified disorders of amniotic fluid and membranes
2.6
6.5
43
164
MBW96
NOMESCO Finland
Other operation after delivery or abortion
3.7
6.5
26
71
Z32.1
ICD-10 Finland
Pregnancy confirmed
1.2
6.2
991
8494
2851A
ICD-9 Finland
Other and unspecified anaemias, Acute posthaemorrhagic anaemia
12.5
6.1
10
8
Z36.4
ICD-10 Finland
Antenatal screening for fetal growth retardation using ultrasound and other physical methods
1.6
6.0
130
800
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
1.9
6.0
76
393
MA2DE
NOMESCO Finland
Detailed ultrasound examination of fetus including color doppler method
1.2
6.0
858
7269

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
398
1385
3.02
85.53
1.7
2.3
3.5
3.7
g/l
2.75
373
1302
695
4641
1.57
24.79
1.7
2.0
28.6
28.9
s
0.94
663
4472
834
5892
1.49
22.76
1.5
1.5
—
—
—
0
0
1210
9712
1.31
14.76
2.3
2.1
—
—
—
0
0
1380
11346
1.29
13.93
1.9
1.8
—
—
—
0
0
275
1711
1.64
13.05
1.7
1.8
20.8
20.6
s
0.23
237
1372
1745
14917
1.25
12.44
1.7
1.7
—
—
—
0
0
2807
25327
1.22
11.73
4.4
3.9
—
—
—
0
0
2001
17448
1.23
11.69
1.8
1.8
—
—
—
0
0
1805
15571
1.24
11.66
1.9
1.8
—
—
—
0
0
937
7628
1.28
9.81
1.6
1.5
—
—
—
0
0
1389
11931
1.22
8.86
4.1
4.2
1.1
1.0
inr
0.52
496
4242
2093
18787
1.18
8.11
2.0
2.0
—
—
—
0
0
48
198
2.44
7.63
1.2
1.2
—
—
—
0
0
400
3006
1.36
7.45
2.4
3.1
—
—
—
0
0
2121
19269
1.16
6.70
2.2
1.9
—
—
—
0
0
29
106
2.75
5.94
1.0
1.0
—
—
—
0
0
1111
9663
1.19
5.89
3.0
3.0
98.6
100.4
%
2.17
1078
9329
168
1225
1.38
3.93
1.6
1.5
—
—
—
0
0
121
836
1.46
3.83
2.9
3.3
22.1
22.5
mg/l
0.04
75
510
686
5969
1.17
3.56
1.2
1.2
—
—
—
0
0
87
578
1.51
3.39
3.4
3.1
—
—
—
0
0
4240
43527
0.89
3.35
11.7
11.7
332.5
332.2
g/l
2.08
4206
43243
998
11038
0.88
3.15
3.2
3.2
—
—
—
0
0
557
4828
1.17
3.05
1.6
1.6
—
—
—
0
0
977
10784
0.89
2.98
3.2
3.4
1.0
1.0
kg/l
0.85
165
1751
544
4740
1.16
2.80
1.5
1.5
—
—
—
0
0
11
36
3.06
2.80
1.3
1.3
—
—
—
0
0
544
4747
1.16
2.75
1.5
1.5
—
—
—
0
0
1582
14762
1.10
2.63
3.9
4.4
1.2
1.2
mmol/l
3.57
1439
13630
30
525
0.57
2.51
1.7
1.7
50.3
49.2
mu/l
0.02
25
487
2511
24005
1.08
2.35
3.5
3.6
6.1
6.2
mmol/l
3.15
2144
21061
301
2548
1.19
2.25
2.4
2.2
5.3
4.8
umol/l
0.69
198
1871
176
2169
0.81
2.14
2.3
3.1
57.8
73.3
ng/l
5.19
159
1974
5172
51177
1.17
2.11
9.6
9.0
—
—
—
0
0
10
237
0.42
2.10
2.0
1.5
116.4
126.7
nmol/l
—
10
237
2144
20438
1.08
2.09
1.9
1.9
—
—
—
0
0
226
1889
1.20
1.98
1.3
1.3
24.1
26.5
u/l
0.51
181
1560
194
2339
0.82
1.94
1.1
1.1
1.0
8.9
u/ml
—
5
32
78
1051
0.74
1.93
1.2
1.2
266.6
258.1
u/ml
0.08
55
733
4876
48101
1.12
1.92
9.2
9.4
18.1
17.7
mg/l
0.40
3880
37409
1773
16831
1.08
1.89
4.4
5.0
1.2
1.2
mmol/l
6.80
1491
14316
3418
33230
1.08
1.88
4.0
3.9
920.4
1863.3
e6/l
1.19
39
341
21
114
1.85
1.86
1.0
1.2
—
—
—
0
0
2666
27620
0.93
1.84
2.6
2.5
—
—
—
0
0
85
639
1.34
1.82
2.1
2.2
—
—
—
0
0
52
740
0.70
1.82
1.4
1.6
4686.6
7421.8
e6/l
1.10
36
555
216
1819
1.20
1.78
1.4
1.4
0.5
0.5
nmol/l
0.09
181
1433
722
7874
0.90
1.77
3.5
3.8
11.8
10.9
mg/mmol
0.20
436
5024
77
1019
0.75
1.72
4.0
4.6
1.3
1.2
mmol/l
0.85
66
901
120
954
1.26
1.72
1.1
1.2
—
—
—
0
0
57
406
1.41
1.71
1.1
1.2
—
—
—
0
0
31
481
0.64
1.69
1.2
1.4
—
—
—
0
0
1187
11137
1.08
1.69
1.8
1.7
1.3
0.8
mg/l
5.01
925
8311
518
4679
1.12
1.64
3.1
3.2
—
—
—
0
0
33
500
0.66
1.63
3.5
3.0
34.9
32.1
umol/l
0.36
28
435
32
487
0.66
1.61
1.3
1.4
267.3
340.7
pmol/l
1.61
24
376
34
510
0.66
1.60
1.3
1.2
—
—
—
0
0
127
1028
1.24
1.58
3.1
2.6
—
—
—
0
0
4497
45633
0.92
1.58
4.9
5.0
1.6
1.8
mu/l
1.72
4303
43714
317
3599
0.87
1.57
3.3
4.7
1.0
1.0
mmol/l
0.64
304
3398
513
5643
0.90
1.51
2.4
2.3
2.4
2.4
mmol/l
0.32
447
4897
112
900
1.25
1.50
3.1
3.5
56.0
57.1
%
0.50
112
900
967
10326
0.92
1.50
1.3
1.3
7.9
8.4
u/ml
0.12
432
4595
1804
18832
0.94
1.48
2.2
2.2
75.9
4678.2
nmol/l
0.50
1704
17812
5420
53949
1.25
1.46
14.7
14.3
131.4
133.1
g/l
22.92
5395
53616
1162
12302
0.93
1.44
3.0
2.9
2.3
2.3
mmol/l
0.02
1054
11253
89
701
1.27
1.42
1.9
2.0
135.7
131.4
g/l
1.38
65
538
264
3010
0.87
1.42
1.6
1.9
—
—
—
0
0
58
431
1.35
1.40
1.7
1.6
5.4
5.6
mmol/l
0.26
53
368
242
2106
1.16
1.40
1.2
1.2
11.8
12.2
u/l
0.20
218
1809
221
1911
1.16
1.39
1.2
1.3
2.9
3.9
ug/l
2.74
200
1771
35
239
1.47
1.36
1.1
1.1
—
—
—
0
0
278
3147
0.88
1.35
1.2
1.3
—
—
—
0
0
14
75
1.87
1.34
1.4
2.2
—
—
—
0
0
1447
15168
0.94
1.33
3.7
4.0
37.1
37.0
g/l
0.31
1351
14243
81
637
1.28
1.33
1.4
1.3
—
—
—
0
0
5417
53933
1.23
1.32
14.6
14.2
7.0
6.7
e9/l
11.38
5354
53078
5415
53917
1.22
1.27
14.5
14.1
30.0
30.0
pg
0.24
5390
53590
5416
53928
1.22
1.27
14.5
14.2
4.4
4.5
e12/l
18.52
5353
53104
5411
53874
1.22
1.27
14.5
14.2
260.1
267.5
e9/l
16.96
5354
53100
42
576
0.73
1.27
1.2
1.5
—
—
—
0
0
21
130
1.62
1.26
1.3
1.1
3.4
3.7
iu/ml
—
5
6
5415
53921
1.22
1.24
14.5
14.1
90.1
90.1
fl
0.18
5389
53594
36
504
0.71
1.23
1.2
1.2
—
—
nmol/l
—
0
0
56
425
1.32
1.22
1.1
1.1
3.1
8.2
iu/ml
3.79
18
125
125
1490
0.84
1.21
4.1
4.7
—
—
—
0
0
703
7534
0.92
1.21
2.9
3.2
338.7
551.8
mg/l
0.71
418
4689
14
78
1.80
1.21
1.0
1.0
—
—
—
0
0
129
1532
0.84
1.20
5.7
6.3
23.2
24.3
mmol/l
4.13
121
1421
477
5183
0.91
1.14
1.6
1.6
—
—
—
0
0
590
5475
1.09
1.14
2.2
2.3
5.0
4.8
e6/l
0.11
327
2863
47
621
0.75
1.13
5.1
6.0
11.1
10.9
mmol/l
0.18
42
553
47
621
0.75
1.13
5.1
6.0
106.5
105.7
mmol/l
0.57
42
553
100
824
1.22
1.13
1.9
2.3
—
—
—
0
0
2096
20295
1.05
1.10
7.2
7.3
0.0
0.0
e9/l
0.22
1784
16885
535
5771
0.92
1.09
2.6
2.6
363.4
306.3
ng/l
0.12
289
2644
5
21
2.38
1.09
1.2
1.9
—
—
—
0
0
64
806
0.79
1.08
1.4
1.5
0.7
0.6
g/l
0.50
46
616
1013
10667
0.94
1.08
1.3
1.3
21.1
27.0
iu/ml
0.92
315
3450
274
3049
0.89
1.06
2.2
2.0
—
—
—
0
0
26
372
0.70
1.04
1.7
1.5
—
—
—
0
0
26
372
0.70
1.04
1.7
1.5
—
—
—
0
0
26
372
0.70
1.04
1.7
1.5
—
—
—
0
0
26
372
0.70
1.04
1.7
1.5
—
—
—
0
0
349
3180
1.10
1.02
1.1
1.1
120.4
217.9
titre
0.71
12
90
274
3039
0.90
1.01
2.1
1.9
—
—
—
0
0
273
3028
0.90
1.01
2.1
2.0
—
—
—
0
0
22
322
0.68
1.00
1.1
1.2
—
68.0
—
0
5
20
298
0.67
1.00
2.3
2.5
36.9
71.8
mg/l
0.50
14
207
890
9386
0.94
1.00
2.8
3.1
7.2
7.7
mmol/l
2.04
772
8226
109
921
1.19
0.98
1.2
1.2
2.7
4.3
u/ml
1.86
41
367
0
30
0.00
0.97
0.0
1.0
—
0.1
—
0
12
0
31
0.00
0.96
0.0
1.3
—
0.2
—
0
12
1233
11815
1.06
0.95
3.2
3.8
—
—
—
0
0
4040
40947
0.95
0.95
4.4
4.4
14.2
14.2
pmol/l
0.62
3826
38975
270
2983
0.90
0.94
1.1
1.1
—
—
—
0
0
18
117
1.54
0.93
1.1
1.0
1.2
1.6
u/ml
0.12
11
77
107
909
1.18
0.92
1.4
1.3
—
—
—
0
0
55
436
1.26
0.92
1.3
1.2
—
—
—
0
0
1050
10988
0.95
0.92
1.3
1.4
2.1
2.1
g/l
0.62
685
7239
10
55
1.82
0.92
1.2
1.2
—
—
—
0
0
604
5667
1.07
0.92
1.1
1.2
—
—
—
0
0
648
6100
1.07
0.90
1.3
1.3
28.8
28.8
iu/l
0.01
592
5417
490
4566
1.08
0.90
1.2
1.3
—
—
—
0
0
5
105
0.48
0.88
1.2
1.1
—
297.1
—
0
7
2077
20199
1.05
0.88
2.2
2.2
—
—
—
0
0
2814
27555
1.04
0.86
3.0
2.9
64.8
65.1
ug/l
0.05
2671
26310
58
468
1.24
0.85
1.0
1.1
—
—
—
0
0
925
8834
1.06
0.82
2.4
2.4
—
—
—
0
0
92
1079
0.85
0.82
1.5
1.4
8663.3
1225.1
e6/l
0.57
77
898
92
1078
0.85
0.81
1.5
1.3
24.6
23.4
e6/l
0.04
74
850
1291
13389
0.95
0.81
1.3
1.3
1.6
1.6
u/ml
0.02
416
4126
763
8022
0.94
0.80
2.1
2.2
7.3
8.5
e6/l
1.59
652
6905
11
176
0.62
0.79
3.1
2.0
—
—
—
0
0
43
542
0.79
0.79
2.4
2.6
79.5
96.0
ug/min
0.09
26
361
6
33
1.82
0.79
1.0
1.2
1.8
1.5
umol/24h
—
6
33
35
268
1.31
0.79
2.8
2.7
—
26.4
—
0
5
8
48
1.67
0.78
1.3
1.2
—
—
—
0
0
0
26
0.00
0.78
0.0
1.0
—
0.0
—
0
7
459
4902
0.93
0.78
1.6
1.7
1203.2
1189.3
nmol/l
0.13
358
4019
1545
14968
1.04
0.77
2.7
2.7
—
—
—
0
0
70
584
1.20
0.77
1.5
1.3
—
—
—
0
0
443
4731
0.93
0.76
1.2
1.2
—
—
—
0
0
61
503
1.22
0.76
1.5
1.6
—
—
—
0
0
3363
34139
0.96
0.74
3.4
3.6
8.8
9.2
mm/h
1.20
3177
32388
7
39
1.80
0.72
1.3
1.1
20.4
20.8
mmol/l
—
7
31
9
56
1.61
0.72
1.1
1.2
—
—
—
0
0
944
9834
0.95
0.72
1.8
1.9
141.3
131.6
u/l
0.16
917
9367
67
562
1.19
0.71
1.8
2.0
—
—
—
0
0
7
40
1.75
0.71
1.4
1.5
—
—
—
0
0
17
241
0.70
0.71
2.2
2.0
—
1.5
—
0
31
176
1950
0.90
0.70
4.4
6.5
6.5
6.6
mmol/l
0.18
170
1881
18
126
1.43
0.70
1.1
1.1
—
—
—
0
0
3474
34254
1.04
0.69
3.8
3.9
—
—
—
0
0
1275
13169
0.96
0.67
2.2
2.3
53.6
57.0
u/l
2.41
1191
12363
650
6191
1.06
0.66
2.4
2.3
9139.6
7248.3
u/l
0.74
358
2868
112
1267
0.88
0.65
1.1
1.2
—
—
—
0
0
1835
18802
0.96
0.65
2.8
3.0
—
6.1
—
0
7
86
745
1.16
0.64
1.0
1.1
—
—
—
0
0
66
775
0.85
0.64
1.1
1.1
14.4
12654.1
iu/ml
0.64
23
212
10
154
0.65
0.64
18.1
16.0
907.7
1362.6
nmol/l
—
10
144
5
29
1.72
0.64
1.4
1.1
—
—
—
0
0
21
281
0.75
0.63
1.2
1.4
4004.5
23383.5
e6/l
1.21
11
198
255
2757
0.92
0.63
2.2
2.1
—
—
—
0
0
69
589
1.17
0.63
2.4
2.4
—
—
—
0
0
837
8039
1.05
0.63
1.5
1.6
—
—
—
0
0
108
955
1.13
0.62
1.2
1.3
—
—
—
0
0
691
7222
0.95
0.61
2.2
2.3
526.4
530.4
mosm/kgh2o
0.15
573
6120
463
4380
1.06
0.61
1.8
2.2
23.5
24.7
%
1.07
389
3782
34
271
1.26
0.60
1.1
1.1
0.2
2.6
nmol/l
—
10
40
0
20
0.00
0.60
0.0
2.3
—
—
—
0
0
110
976
1.13
0.60
1.3
1.2
—
—
—
0
0
45
543
0.83
0.60
1.2
1.3
—
—
—
0
0
190
1738
1.10
0.60
1.4
1.4
52.0
83.8
pmol/l
2.62
185
1698
2186
22302
0.97
0.60
4.7
5.2
0.0
0.0
e9/l
1.41
1981
19796
89
779
1.14
0.60
1.1
1.1
—
—
—
0
0
399
3761
1.07
0.59
2.2
2.4
29.2
30.3
u/ml
0.13
385
3642
45
542
0.83
0.59
1.2
1.3
6.7
6.6
g/l
0.15
29
378
3166
32098
0.97
0.58
6.2
6.2
72.4
72.1
u/l
0.15
2984
30420
45
541
0.83
0.58
1.2
1.3
0.4
0.4
g/l
0.28
31
376
45
541
0.83
0.58
1.2
1.3
3.2
3.1
g/l
0.19
31
374
55
464
1.19
0.58
1.7
1.8
8.4
330.4
u/ml
0.49
41
366
191
2081
0.91
0.58
1.1
1.2
—
—
—
0
0
106
942
1.13
0.57
1.8
2.4
24.4
24.7
mmol/l
0.99
100
877
3770
38101
0.97
0.56
3.6
3.9
36.9
37.2
mmol/mol
1.81
3598
36374
289
2700
1.07
0.56
2.6
3.0
1.2
1.2
mmol/l
0.48
258
2386
96
1083
0.88
0.56
1.2
1.2
3.5
3.6
mmol/l
0.48
88
1027
1071
10374
1.04
0.56
2.0
2.0
2.7
2.6
mg/l
0.41
928
9030
28
352
0.79
0.55
1.2
1.4
10.0
9.3
umol/l
0.55
28
340
235
2531
0.93
0.55
1.4
1.3
3.7
0.8
u/ml
0.75
15
222
204
1882
1.09
0.55
7.5
7.2
—
—
—
0
0
10
148
0.68
0.55
14.5
11.6
529.7
731.0
nmol/l
—
10
141
160
1751
0.91
0.55
2.7
2.5
73.0
71.6
e9/l
0.19
116
1269
429
4068
1.06
0.54
1.3
1.3
135.3
160.8
u/ml
0.48
399
3790
90
1015
0.88
0.53
3.5
4.4
1.6
1.8
%
1.71
85
937
20
261
0.77
0.53
1.1
1.1
—
—
—
0
0
160
1463
1.10
0.53
6.5
6.7
—
—
—
0
0
276
2948
0.93
0.53
3.2
3.2
—
—
—
0
0
18
134
1.34
0.53
1.0
1.4
—
—
—
0
0
9
63
1.43
0.52
1.0
1.1
—
—
—
0
0
40
479
0.83
0.51
1.8
1.5
—
—
—
0
0
250
2676
0.93
0.51
1.4
1.4
—
—
—
0
0
129
1421
0.91
0.51
1.2
1.1
—
—
—
0
0
214
2304
0.93
0.51
2.3
2.2
—
—
—
0
0
613
5879
1.05
0.51
2.1
2.2
0.8
1.1
e6/l
2.10
345
3253
170
1847
0.92
0.51
2.0
2.3
0.1
0.2
e6/l
1.64
158
1752
16
214
0.75
0.51
2.2
2.7
51.0
44.1
%
—
6
76
89
999
0.89
0.50
3.5
4.6
0.9
1.0
%
0.93
84
923
14
101
1.39
0.49
1.2
2.0
—
—
—
0
0
492
4705
1.05
0.47
1.3
1.4
—
—
—
0
0
17
128
1.33
0.47
1.3
1.5
—
—
—
0
0
7
47
1.49
0.47
2.1
2.4
—
—
—
0
0
537
5147
1.05
0.47
1.6
1.7
—
—
—
0
0
147
1600
0.92
0.47
1.8
2.2
57.4
70.9
ng/l
0.54
132
1419
26
321
0.81
0.46
2.3
1.5
1.8
1.2
promille
0.98
19
236
23
182
1.26
0.46
1.1
1.1
—
—
—
0
0
349
3677
0.95
0.46
1.4
1.5
275.7
289.3
mu/l
0.41
309
3266
115
1045
1.10
0.45
1.8
2.5
—
—
—
0
0
5
82
0.61
0.45
1.0
1.2
—
—
—
0
0
119
1084
1.10
0.45
1.1
1.1
3.7
3.0
u/ml
0.16
65
603
1329
13606
0.97
0.45
3.3
3.4
0.0
0.0
estimate
2.55
589
5276
153
1658
0.92
0.45
1.8
1.8
9.1
4.8
ug/l
0.39
138
1469
767
7927
0.96
0.45
1.4
1.4
639.4
568.8
titre
0.35
137
1597
999
10274
0.97
0.45
1.6
1.6
1.3
1.3
mmol/l
0.51
858
9031
1436
14681
0.97
0.44
2.9
3.1
76.0
66.3
e6/l
0.26
920
9452
952
9798
0.97
0.44
2.9
3.3
7.4
7.4
ph
1.34
208
1962
269
2853
0.94
0.44
2.3
2.1
0.2
0.2
g/l
0.28
256
2701
33
274
1.21
0.44
2.2
1.8
1.8
2.4
u/field
—
8
141
92
829
1.11
0.43
1.3
1.5
—
—
—
0
0
30
248
1.21
0.42
1.9
2.8
0.1
0.3
e9/l
0.98
30
243
246
2610
0.94
0.42
2.2
2.5
1.7
1.7
%
0.12
224
2362
51
444
1.15
0.41
1.2
1.2
—
—
—
0
0
39
456
0.85
0.41
1.1
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
0.4
—
0
11
341
3579
0.95
0.41
2.0
2.0
4.0
4.1
e9/l
0.14
281
3096
2467
25006
0.98
0.40
3.0
3.2
0.0
0.0
estimate
0.96
581
5148
35
296
1.18
0.40
1.1
1.4
—
—
—
0
0
91
1003
0.91
0.40
1.3
1.3
301.3
326.8
ug/g
0.55
46
510
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
0.1
—
0
12
118
1084
1.09
0.39
1.0
1.1
4.2
4.1
u/ml
0.01
42
426
877
9015
0.97
0.39
1.5
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
27
324
0.83
0.39
1.0
1.0
—
—
—
0
0
2277
23090
0.98
0.38
4.6
5.1
2.0
2.0
e9/l
0.37
2092
20970
198
2106
0.94
0.38
3.5
2.8
—
—
—
0
0
25
206
1.21
0.37
1.6
1.9
11.0
9.6
mg/l
0.71
18
169
2191
22222
0.98
0.37
4.7
5.2
0.5
0.5
e9/l
0.02
1987
19788
307
3221
0.95
0.37
1.2
1.2
—
—
—
0
0
9
69
1.30
0.37
1.0
1.2
—
—
—
0
0
161
1505
1.07
0.36
2.0
2.5
7.4
7.4
ph
0.88
20
206
3438
34079
1.02
0.36
2.6
2.7
33.8
33.2
u/l
0.17
3302
32804
24
289
0.83
0.36
1.3
1.3
—
—
—
0
0
34
396
0.86
0.36
3.3
4.0
6.0
6.9
mmol/l
1.00
27
312
5
76
0.66
0.35
1.0
1.4
—
—
—
0
0
133
1236
1.08
0.35
2.5
2.9
0.2
0.3
g/l
0.78
52
506
20
162
1.24
0.35
1.8
2.3
—
—
—
0
0
5
80
0.62
0.35
2.4
2.9
0.9
0.9
nmol/l
—
5
52
2033
20622
0.98
0.35
5.0
4.9
9.7
9.3
umol/l
1.19
1910
19449
135
1449
0.93
0.35
1.5
1.6
6.5
6.5
mmol/l
0.10
88
1034
10
73
1.37
0.34
1.0
1.1
—
—
—
0
0
18
222
0.81
0.34
1.0
1.1
—
—
—
0
0
57
509
1.12
0.34
1.0
1.1
6.5
1.2
u/ml
0.39
12
132
2480
25091
0.98
0.34
4.2
4.3
0.0
0.0
estimate
0.31
593
5322
12
91
1.32
0.33
1.0
1.1
—
—
—
0
0
121
1124
1.08
0.33
2.2
2.1
1.0
1.3
g/l
4.96
103
985
120
1291
0.93
0.33
3.1
2.7
—
—
—
0
0
15
118
1.27
0.33
1.2
1.2
12.1
3.1
u/ml
—
5
18
518
5013
1.04
0.33
1.6
1.8
—
—
—
0
0
442
4267
1.04
0.32
3.7
3.4
4.6
4.5
pmol/l
0.53
403
3894
4660
46395
1.03
0.31
10.0
9.9
39.0
39.5
%
4.68
3829
38582
122
1137
1.07
0.31
1.0
1.1
6.0
5.1
u/ml
0.13
40
425
28
239
1.17
0.31
2.5
2.3
—
—
—
0
0
338
3516
0.96
0.31
1.2
1.2
—
—
—
0
0
4253
42298
1.02
0.31
11.1
11.1
13.5
13.4
%
0.37
4195
41596
22
262
0.84
0.31
3.8
2.3
56.5
56.0
%
0.03
13
173
4503
45241
0.97
0.31
3.4
3.6
3.0
3.0
mmol/l
0.68
4292
43171
33
286
1.15
0.31
2.2
2.7
—
—
—
0
0
7
96
0.73
0.30
1.4
1.6
—
—
—
0
0
10
131
0.76
0.30
1.3
1.5
—
—
—
0
0
7
99
0.71
0.30
2.3
1.6
—
—
—
0
0
7
100
0.70
0.30
4.1
3.7
—
—
—
0
0
76
829
0.92
0.30
3.4
3.7
1.5
1.3
mmol/l
0.70
76
819
153
1622
0.94
0.29
2.2
2.2
—
—
—
0
0
52
577
0.90
0.29
1.2
1.4
—
—
—
0
0
16
195
0.82
0.28
1.1
1.1
—
—
—
0
0
241
2517
0.96
0.27
1.6
1.8
1.3
1.3
g/l
0.07
223
2371
510
4955
1.03
0.27
1.5
1.4
—
—
—
0
0
44
491
0.90
0.27
2.9
3.2
23.9
42.3
mg/l
1.26
36
392
49
441
1.11
0.27
1.6
2.5
1.3
1.4
e9/l
0.30
28
257
65
710
0.91
0.27
2.3
2.0
152.9
241.2
ug/l
0.87
59
617
281
2924
0.96
0.27
1.2
1.2
—
—
—
0
0
293
3046
0.96
0.27
3.5
4.0
0.0
0.2
%
0.60
46
531
161
1525
1.06
0.27
2.0
2.5
5.0
5.1
kpa
0.59
151
1415
27
233
1.16
0.27
1.1
1.1
8.6
6.7
u/ml
—
6
39
15
183
0.82
0.27
3.1
1.8
417.7
186.3
umol/l
—
9
89
21
177
1.19
0.27
2.7
2.8
—
—
—
0
0
19
226
0.84
0.27
1.4
1.8
—
—
—
0
0
29
252
1.15
0.27
1.0
1.0
—
—
—
0
0
70
643
1.09
0.27
4.2
4.1
189.9
87.8
u/ml
0.52
25
215
330
3185
1.04
0.26
2.6
2.6
—
—
—
0
0
376
3638
1.04
0.26
2.2
2.3
33.6
35.7
u/l
0.18
307
3132
1041
10600
0.98
0.26
5.2
5.5
—
—
—
0
0
136
1284
1.06
0.26
1.0
1.1
1.5
1.3
u/ml
0.20
32
315
15
182
0.82
0.26
1.2
1.2
—
—
—
0
0
18
214
0.84
0.26
2.1
1.7
—
—
—
0
0
39
436
0.89
0.26
1.2
1.2
—
—
—
0
0
159
1674
0.95
0.25
2.2
2.0
1.2
1.2
g/l
0.13
148
1598
105
1120
0.94
0.25
1.2
1.2
—
—
—
0
0
44
488
0.90
0.25
2.9
3.2
18.4
24.9
mg/l
2.02
36
390
1247
12275
1.02
0.25
2.2
2.2
15.2
22.0
ng/l
1.76
475
4581
2504
25270
0.98
0.25
3.1
3.2
0.0
0.0
estimate
0.47
587
5264
58
632
0.92
0.24
2.3
2.7
2.3
2.1
mmol/l
0.17
32
377
145
1376
1.06
0.24
9.2
8.1
1.3
1.5
%
1.46
145
1367
280
2903
0.96
0.24
9.0
8.5
1.2
1.1
inr
0.46
29
551
11
137
0.80
0.24
1.3
1.5
41.1
36.8
g/l
0.73
11
128
292
3022
0.96
0.23
3.3
3.8
0.7
0.6
%
0.23
45
493
5
38
1.32
0.23
2.0
2.8
29.8
39.4
pmol/l
—
5
29
34
380
0.89
0.23
1.2
1.6
46.6
46.2
%
0.02
21
214
450
4621
0.97
0.23
1.3
1.4
—
—
—
0
0
16
134
1.19
0.22
1.0
1.4
—
—
—
0
0
67
621
1.08
0.22
1.5
1.4
—
—
—
0
0
115
1215
0.95
0.22
1.3
1.3
535.6
452.2
mg/l
0.59
110
1170
39
352
1.11
0.22
1.5
2.1
13.3
12.6
%
0.10
16
188
39
352
1.11
0.22
1.1
1.2
—
—
—
0
0
2297
23176
0.98
0.22
4.7
5.2
0.2
0.2
e9/l
0.19
2105
20997
1337
13550
0.98
0.22
1.6
1.7
103.1
100.3
pmol/l
1.31
723
7435
21
242
0.87
0.22
3.1
6.6
9.8
10.8
mg/l
0.47
16
228
5
41
1.22
0.22
1.0
1.7
65.4
55.6
%
—
5
35
25
284
0.88
0.22
2.3
2.6
—
—
—
0
0
177
1696
1.05
0.21
1.1
1.2
—
—
—
0
0
191
1989
0.96
0.21
2.1
3.1
2.0
1.8
mmol/l
0.23
153
1592
102
1080
0.94
0.21
1.2
1.3
112.3
109.6
u/ml
0.18
33
274
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
11.1
—
—
—
0
0
192
1844
1.04
0.21
2.8
2.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
427
4380
0.97
0.21
1.9
2.0
374.2
372.5
nmol/l
0.07
403
4074
12
145
0.83
0.21
1.2
1.3
—
0.3
—
0
8
119
1130
1.05
0.21
1.1
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
465.2
—
0
13
143
1366
1.05
0.20
1.0
1.1
5.6
5.3
u/ml
0.07
59
691
572
5601
1.02
0.20
1.2
1.2
148.5
155.7
iu/ml
0.16
219
2346
336
3266
1.03
0.20
2.2
2.4
10.6
10.5
g/l
0.17
297
3022
240
2320
1.04
0.20
1.7
1.7
—
—
—
0
0
39
355
1.10
0.20
1.8
2.2
51.4
44.9
%
—
8
56
43
469
0.92
0.20
2.9
3.1
1.5
1.4
ratio
—
5
68
514
5030
1.02
0.19
1.7
2.0
2.6
2.5
g/l
1.81
468
4672
71
665
1.07
0.19
3.0
2.9
—
—
—
0
0
6
51
1.18
0.19
2.2
1.8
—
—
—
0
0
2106
20880
1.01
0.19
4.8
5.4
7.8
7.8
%
0.06
2006
19741
155
1616
0.96
0.19
2.2
2.0
0.2
0.2
g/l
0.19
144
1539
179
1860
0.96
0.19
2.0
2.1
68.0
67.6
g/l
0.28
162
1734
70
746
0.94
0.19
2.1
2.7
7.4
7.4
ph
0.61
57
623
4461
44751
0.98
0.18
3.3
3.4
1.5
1.6
mmol/l
1.69
4282
42995
144
1381
1.04
0.18
9.2
8.1
0.7
0.7
%
0.01
144
1374
109
1038
1.05
0.18
2.3
2.4
—
—
—
0
0
26
290
0.90
0.18
2.3
2.5
—
—
—
0
0
271
2632
1.03
0.18
7.0
6.4
14.6
13.9
kpa
1.04
260
2520
4914
49028
1.02
0.18
9.0
9.5
64.3
65.1
umol/l
3.16
4909
49002
37
404
0.92
0.18
1.3
1.2
—
—
—
0
0
271
2633
1.03
0.18
7.0
6.4
4.9
5.0
kpa
0.72
260
2523
80
756
1.06
0.17
1.4
1.3
28.1
49.8
u/ml
—
6
51
489
4990
0.98
0.17
2.7
3.0
0.8
0.8
mmol/l
0.77
460
4725
278
2704
1.03
0.17
3.4
3.5
11.8
34.7
ug/l
0.86
186
1909
24
268
0.90
0.17
1.3
1.2
—
—
—
0
0
188
1817
1.04
0.17
2.1
2.2
3.9
8.3
iu/l
0.59
77
798
190
1837
1.04
0.17
1.6
1.6
7.4
7.5
mmol/l
0.18
113
1113
577
5668
1.02
0.17
1.8
2.1
14.8
14.9
umol/l
0.18
527
5268
17
148
1.15
0.16
1.1
1.1
—
—
—
0
0
461
4702
0.98
0.16
2.3
2.3
6.4
5.8
umol/l
0.30
376
3992
35
381
0.92
0.16
2.5
3.4
—
—
—
0
0
87
914
0.95
0.16
1.0
1.1
—
—
—
0
0
153
1476
1.04
0.15
1.4
1.3
2.1
9.3
u/ml
1.22
18
156
118
1132
1.04
0.15
1.2
1.2
—
—
—
0
0
17
193
0.88
0.15
1.1
1.1
—
—
—
0
0
4949
49585
0.98
0.15
7.8
8.0
24.1
24.2
u/l
0.20
4805
48405
2532
25469
0.99
0.15
6.8
7.3
3.9
3.9
e9/l
0.39
2273
22566
18
159
1.13
0.15
1.2
1.5
11.6
5.8
%
—
8
26
322
3293
0.98
0.15
3.4
3.9
1.0
0.9
%
0.23
63
673
1533
15462
0.99
0.14
2.7
2.9
30.6
28.9
u/l
0.38
1455
14844
778
7680
1.02
0.14
3.1
3.3
—
—
—
0
0
39
419
0.93
0.14
1.3
1.2
—
—
—
0
0
136
1407
0.97
0.13
2.0
1.9
—
—
—
0
0
4282
42935
0.99
0.13
3.2
3.3
5.5
5.5
mmol/l
0.96
4060
40804
747
7375
1.01
0.13
2.4
2.4
115.7
98.1
ug/g
0.85
582
5792
155
1502
1.03
0.13
1.4
1.3
7.5
6.9
u/ml
0.05
25
250
82
856
0.96
0.12
3.0
3.2
98.8
255.2
u/ml
0.44
72
713
36
386
0.93
0.12
1.1
1.1
307.7
298.2
mg/l
0.23
30
361
311
3172
0.98
0.12
3.4
4.0
0.2
0.2
%
0.16
57
627
12
104
1.15
0.12
1.3
1.6
—
—
—
0
0
39
365
1.07
0.12
6.9
6.3
—
—
—
0
0
225
2302
0.98
0.12
7.3
6.9
96.9
96.5
%
0.37
215
2199
46
487
0.94
0.11
1.1
1.1
—
—
—
0
0
155
1507
1.03
0.11
1.8
1.8
—
—
—
0
0
4484
44935
0.99
0.11
3.3
3.4
4.9
4.9
mmol/l
1.57
4305
43193
789
7805
1.01
0.11
1.3
1.3
—
—
—
0
0
43
405
1.06
0.11
2.1
2.1
—
—
—
0
0
4539
45297
1.01
0.11
7.9
8.4
139.5
139.6
mmol/l
3.01
4436
44218
135
1310
1.03
0.11
1.3
1.3
104.7
157.9
titre
0.50
15
126
44
466
0.94
0.11
2.2
2.9
—
—
—
0
0
25
230
1.09
0.11
1.2
1.4
—
—
—
0
0
49
464
1.06
0.11
1.1
1.2
0.4
0.9
u/ml
0.53
15
177
40
425
0.94
0.11
2.2
2.6
0.8
1.5
%
1.98
32
331
116
1123
1.03
0.11
2.0
1.8
—
—
—
0
0
2005
19940
1.01
0.11
4.6
5.3
0.7
0.7
%
0.54
1898
18681
34
363
0.94
0.11
1.0
1.1
—
—
—
0
0
15
134
1.12
0.10
1.1
1.1
—
—
—
0
0
15
167
0.90
0.10
1.4
1.4
—
—
—
0
0
10
115
0.87
0.10
1.4
1.6
—
—
—
0
0
47
495
0.95
0.10
1.2
1.1
1.1
1.0
ratio
0.08
17
184
19
173
1.10
0.10
2.8
3.2
—
—
—
0
0
26
280
0.93
0.10
1.5
1.2
45.5
72.7
%
—
6
27
2088
20776
1.01
0.10
4.6
5.2
2.7
2.8
%
1.16
1978
19431
345
3505
0.98
0.10
1.3
1.3
43.0
34.2
au/ml
0.27
13
163
269
2642
1.02
0.10
7.0
6.5
-0.3
0.8
mmol/l
5.01
191
1993
28
300
0.93
0.10
1.9
2.8
839.5
863.9
e6/l
0.06
15
133
1134
11424
0.99
0.09
2.5
2.6
45.3
75.8
e6/l
0.83
837
8495
237
2415
0.98
0.09
1.1
1.1
—
—
—
0
0
96
930
1.03
0.09
1.0
1.1
0.3
0.4
u/ml
0.08
14
186
204
1999
1.02
0.09
1.7
1.7
—
—
—
0
0
99
1020
0.97
0.09
2.1
2.6
0.7
0.7
%
0.17
91
976
132
1287
1.03
0.09
1.0
1.1
0.6
1.2
u/ml
1.61
45
508
17
186
0.91
0.09
1.3
1.7
—
—
—
0
0
25
233
1.07
0.09
1.1
1.4
—
—
—
0
0
766
7594
1.01
0.09
1.5
1.5
16815906.1
47243240.2
pmol/l
1.40
672
6746
15
165
0.91
0.08
1.1
1.2
—
—
—
0
0
134
1372
0.98
0.08
1.3
1.3
40.0
38.7
u/ml
—
9
144
5
62
0.81
0.08
1.4
1.7
—
—
—
0
0
5
63
0.79
0.08
1.4
1.5
—
18.3
—
0
6
39
371
1.05
0.08
1.3
1.4
—
—
—
0
0
5
64
0.78
0.08
1.4
1.2
—
—
—
0
0
26
277
0.94
0.08
2.0
2.8
—
—
—
0
0
10
88
1.14
0.08
1.4
1.4
—
—
—
0
0
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
141
1380
1.02
0.08
1.1
1.1
—
—
—
0
0
117
1143
1.02
0.07
1.2
1.3
—
—
—
0
0
460
4553
1.01
0.07
1.4
1.3
—
—
—
0
0
217
2205
0.98
0.07
7.5
7.1
115.2
122.2
g/l
5.51
210
2109
113
1157
0.98
0.07
1.9
2.1
8.6
10.1
mg/l
1.71
107
1088
37
388
0.95
0.07
1.8
2.9
68.2
62.7
%
0.95
37
388
8
78
1.03
0.07
2.1
1.5
7.6
54.1
u/l
—
8
64
9
87
1.03
0.07
1.1
1.5
—
—
—
0
0
9
88
1.02
0.07
1.1
1.6
63.8
41.5
%
—
9
76
131
1284
1.02
0.06
8.7
8.2
—
—
—
0
0
8
90
0.89
0.06
1.1
1.1
—
—
—
0
0
8
90
0.89
0.06
1.1
1.1
—
—
—
0
0
8
90
0.89
0.06
1.1
1.1
—
—
—
0
0
12
132
0.91
0.06
1.0
1.0
—
—
—
0
0
2183
21760
1.01
0.06
4.6
5.2
30.2
30.2
%
0.12
2075
20495
9
105
0.86
0.06
1.2
1.2
—
—
—
0
0
1337
13430
0.99
0.06
2.2
2.2
—
—
—
0
0
217
2140
1.01
0.06
1.7
1.7
—
—
—
0
0
170
1673
1.02
0.06
1.4
1.3
57.4
31.0
u/ml
0.39
11
129
92
941
0.98
0.06
3.8
4.3
—
—
—
0
0
22
233
0.94
0.05
1.4
1.6
1.0
2.6
u/field
1.42
12
158
58
597
0.97
0.05
1.1
1.1
1.4
1.4
g/l
0.42
49
561
306
3033
1.01
0.04
1.3
1.3
—
—
—
0
0
142
1400
1.01
0.04
1.4
1.3
—
—
—
0
0
58
595
0.97
0.04
2.1
1.7
39.6
39.4
g/l
0.10
47
540
84
825
1.02
0.04
1.4
1.4
11.2
5.1
iu/ml
—
6
15
375
3775
0.99
0.04
2.3
2.3
22.3
23.8
au/ml
0.12
26
324
1361
13648
1.00
0.03
4.9
5.4
—
—
—
0
0
2151
21468
1.00
0.03
4.5
5.0
56.2
56.1
%
0.12
2056
20275
13
121
1.07
0.03
1.0
2.3
—
—
—
0
0
339
3413
0.99
0.03
1.3
1.3
225.9
237.8
miu/ml
0.26
184
1756
81
796
1.02
0.03
1.3
1.3
1.3
1.3
nmol/l
0.10
70
667
196
1942
1.01
0.03
1.1
1.1
13.1
5.2
u/ml
0.40
25
328
1038
10350
1.00
0.03
2.4
2.5
—
—
—
0
0
31
300
1.03
0.03
1.3
1.6
34.3
39.8
%
0.31
21
166
21
218
0.96
0.02
1.1
1.1
2.0
2.2
u/ml
0.04
11
109
23
238
0.97
0.02
1.0
1.2
—
—
—
0
0
28
272
1.03
0.02
1.9
2.3
33.0
32.1
pg
0.48
28
272
34
332
1.02
0.01
1.6
2.5
0.2
0.2
e9/l
0.24
28
279
33
338
0.98
0.01
1.6
2.5
484.5
532.0
e6/l
0.31
27
279
16
153
1.05
0.01
1.2
1.2
—
—
—
0
0
51
502
1.02
0.01
1.6
1.4
—
—
—
0
0
702
7007
1.00
0.01
1.4
1.4
21.4
21.1
nmol/l
0.32
623
6312
4297
42983
1.00
0.01
3.0
3.1
1.2
1.2
mmol/l
0.25
4135
41280
120
1208
0.99
0.01
1.1
1.1
—
—
—
0
0
51
517
0.99
0.01
1.1
1.0
2.0
0.7
u/ml
0.37
11
113
1030
10309
1.00
0.00
2.0
2.0
1448.4
1637.1
umol/l
0.12
927
9304
1025
10258
1.00
0.00
2.5
2.6
0.2
0.3
e6/l
0.51
750
7498
4546
45453
1.00
0.00
8.0
8.5
3.9
3.9
mmol/l
1.78
4424
44265
18
178
1.01
0.00
1.7
2.6
12.4
11.1
%
0.62
18
178
26
262
0.99
0.00
1.1
1.1
—
—
—
0
0
17
165
1.03
0.00
1.2
1.8
—
—
—
0
0
40
402
0.99
0.00
1.1
1.1
1519.5
1480.4
miu/ml
0.10
40
402
51
515
0.99
0.00
1.2
1.2
36.8
37.0
mg/l
0.01
41
432
100
995
1.01
0.00
1.5
1.3
—
—
—
0
0
12
124
0.97
0.00
1.0
1.0
—
—
—
0
0
12
124
0.97
0.00
1.0
1.0
—
—
—
0
0
12
124
0.97
0.00
1.0
1.0
—
—
—
0
0
13
134
0.97
0.00
1.1
1.1
—
—
—
0
0
19
186
1.02
0.00
2.5
2.1
2109.7
1923.2
ml
0.55
19
174
10
103
0.97
0.00
1.1
1.0
—
—
—
0
0
25
246
1.02
0.00
1.9
1.5
—
—
—
0
0
15
153
0.98
0.00
1.1
1.1
—
—
—
0
0
16
157
1.02
0.00
1.2
2.1
266.7
185.5
e6/l
—
9
89
30
296
1.01
0.00
2.1
1.6
—
—
—
0
0
31
306
1.01
0.00
1.1
1.1
8.7
10.7
u/ml
—
6
65
37
366
1.01
0.00
2.0
2.2
—
—
—
0
0
42
416
1.01
0.00
1.1
1.1
—
—
—
0
0
27
267
1.01
0.00
2.7
2.4
—
—
—
0
0
54
544
0.99
0.00
1.9
1.9
18.0
17.0
%
1.49
30
258
32
323
0.99
0.00
2.0
1.7
—
—
—
0
0
102
1024
1.00
0.00
1.2
1.1
7.3
9.7
au/ml
0.29
11
73
104
1036
1.00
0.00
1.8
3.4
24.6
24.2
mmol/l
0.54
90
912
61
607
1.00
0.00
2.3
2.5
24.1
24.1
mmol/l
0.06
55
537
10
99
1.01
0.00
1.1
1.1
—
—
—
0
0
153
1533
1.00
0.00
1.1
1.1
0.6
1.5
u/ml
3.08
49
556
30
299
1.00
0.00
2.7
2.3
—
—
—
0
0
45
451
1.00
0.00
1.0
1.0
—
—
—
0
0
50
501
1.00
0.00
1.1
1.1
197.7
202.7
mg/l
0.14
41
445
89
891
1.00
0.00
1.2
1.4
31.2
30.8
nmol/l
0.04
73
818
0
6
0.00
0.00
0.0
1.0
—
4.5
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
994.6
—
0
6
0
6
0.00
0.00
0.0
6.8
—
14.3
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
0.00
3.2
3.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
0.00
2.2
1.8
16.5
40.0
pmol/l
—
6
58
5
51
0.98
0.00
1.0
1.1
1.9
1.2
u/ml
—
5
35
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
160.2
—
0
5
7
77
0.91
0.00
1.6
2.1
1.9
2.7
ug/l
—
7
67
5
56
0.89
0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
73.3
—
0
9
9
99
0.91
0.00
2.3
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
358.9
—
0
9
121
1210
1.00
0.00
1.1
1.1
—
—
—
0
0
7
73
0.96
0.00
3.3
1.9
—
—
—
0
0
9
91
0.99
0.00
1.1
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
104.2
—
0
7
0
5
0.00
0.00
0.0
9.8
—
10.1
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
8
89
0.90
0.00
1.4
1.6
—
—
—
0
0
5
57
0.88
0.00
1.4
1.2
82.3
41.2
ng/l
—
5
31
0
5
0.00
0.00
0.0
2.0
—
53.4
—
0
5

Mortality – FinRegistry

Association

Association between endpoint O15_POSTPART_HAEMORRH_PLACENTA and mortality.

Females

Parameter HR [95% CI] p-value
O15_POSTPART_HAEMORRH_PLACENTA 0.584 [0.46, 0.74] < 0.001
Birth year 0.994 [0.99, 1.0] 0.144

During the follow-up period (1.1.1998 — 31.12.2019), 93 out of 19150 females with O15_POSTPART_HAEMORRH_PLACENTA died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_POSTPART_HAEMORRH_PLACENTA.

N-year risk Females Males
1 0.043% No data
5 0.36% No data
10 0.906% No data
15 1.602% No data
20 2.71% No data

Relationships between endpoints

Index endpoint: O15_POSTPART_HAEMORRH_PLACENTA – Postpartum haemorrhage due to retained placenta

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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