Asthma and opportunity respiratory infection

ASTHMA_OPPORTUNIST_INFECTIONS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • J10_ASTHMA
61122

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

1648

6. Filter based on genotype QC (FinnGen only)

1648

Control definitions (FinnGen only)

Control conditions
not J10_ASTHMA

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 8980 5319 3578
Only index persons 7807 4794 3013
Unadjusted period prevalence (%)
Whole population 0.13 0.15 0.10
Only index persons 0.15 0.18 0.12
Median age at first event (years)
Whole population 63.65 63.39 64.10
Only index persons 63.61 63.28 64.15

-FinnGen-

Key figures

All Female Male
Number of individuals 1648 997 651
Unadjusted period prevalence (%) 0.32 0.34 0.29
Median age at first event (years) 62.45 60.77 65.03

-FinRegistry-

Age distribution of first events

01020304050607080900.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6k1.8k2.0kAgeIndividuals

-FinnGen-

Age distribution of first events

0102030405060708090050100150200250300350400AgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4k1.6kYearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200020052010201520202023050100150200250300350YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.0AgeProbability of first incidence (%)

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1440
Matched controls
14399
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R03BA05
ATC
fluticasone; inhalant
15.4
323.0
772
1005
J45.9
ICD-10 Finland
Asthma, unspecified
364.7
323.0
1252
260
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
104.5
323.0
1183
605
H02AB06
ATC
prednisolone; systemic
18.0
323.0
1275
4318
J45.1
ICD-10 Finland
Nonallergic asthma
368.9
323.0
664
33
R03AK06
ATC
salmeterol and fluticasone; inhalant
32.5
323.0
879
662
J45
ICD-10 Finland
Asthma
28.1
323.0
488
258
R03DC03
ATC
montelukast; oral
33.5
323.0
864
617
R03BB04
ATC
tiotropium bromide; inhalant
39.7
323.0
856
512
J47
ICD-10 Finland
Bronchiectasis
1421.8
323.0
1265
73
J45.0
ICD-10 Finland
Predominantly allergic asthma
232.2
323.0
607
45
R03AC12
ATC
salmeterol; inhalant
51.8
323.0
424
115
R03AC02
ATC
salbutamol; inhalant
30.0
323.0
1342
4512
R03BA02
ATC
budesonide; inhalant
12.5
323.0
675
950
R03DA04
ATC
theophylline; systemic, rectal
31.4
317.0
431
193
UGC12
NOMESCO Finland
Flexible bronchoscopy
16.0
312.8
554
540
R03BA01
ATC
beclometasone; inhalant
13.9
310.7
595
692
R03AK08
ATC
formoterol and beclometasone; inhalant
75.0
305.4
344
60
J01MA14
ATC
moxifloxacin; systemic
14.7
304.8
564
604
J18.9
ICD-10 Finland
Pneumonia, unspecified
8.8
300.9
876
2158
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
22.3
288.2
438
277
J46
ICD-10 Finland
Status asthmaticus
307.1
277.4
274
11
R96
ICPC
Asthma
22.0
275.2
419
263
J45.8
ICD-10 Finland
Mixed asthma
221.1
267.8
270
15
R03AK07
ATC
formoterol and budesonide; inhalant
9.7
254.7
605
1002
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
8.0
231.8
641
1318
R03BA08
ATC
ciclesonide; inhalant
16.1
217.9
374
308
R03AC13
ATC
formoterol; inhalant
25.7
217.9
312
153
R03AC03
ATC
terbutaline; inhalant
9.5
213.6
497
758
J01FA06
ATC
roxithromycin; oral
6.0
213.5
987
3856
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
10.5
206.0
444
586
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
5.5
190.4
1054
4775
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
14.1
175.6
317
283
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
175.1
1031
4778
H02AB04
ATC
methylprednisolone; systemic
7.1
174.4
499
1003
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
21.4
173.4
263
149
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
17.2
172.2
284
203
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
7.9
169.6
439
758
J01AA02
ATC
doxycycline; systemic
10.3
161.7
1364
9151
49300
ICD-8 Finland
Asthma, bronchiale
+∞
161.6
152
*
J01MA12
ATC
levofloxacin; systemic
5.5
160.2
597
1646
H02AB07
ATC
prednisone; oral
6.5
160.0
485
1036
R03AK11
ATC
formoterol and fluticasone; inhalant
38.7
157.4
201
60
XG474
NOMESCO Finland
Exhalation nntrogen oxide
47.0
154.3
189
46
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
10.3
149.3
316
382
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
7.6
147.1
385
660
R03BB01
ATC
ipratropium bromide; inhalant
14.7
146.9
258
211
J01FA10
ATC
azithromycin; systemic
4.3
139.0
1041
5463
A31.0
ICD-10 Finland
Pulmonary mycobacterial infection
157.3
136.0
142
10
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
23.0
134.6
198
99
R06.0
ICD-10 Finland
Dyspnoea
4.4
134.3
640
2194
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
12.0
129.0
249
247
J01FA09
ATC
clarithromycin; systemic
4.1
128.8
704
2715
TDM10
NOMESCO Finland
Puncture of maxillary antrum
16.1
125.2
210
151
R01AD09
ATC
mometasone; nasal
3.7
120.7
843
3941
R01AD08
ATC
fluticasone; nasal
4.1
117.7
618
2250
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
91.2
113.2
125
15
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
129.6
111.9
119
10
XG410
NOMESCO Finland
Flow-volume spirometry
12.3
111.8
212
200
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
8.7
110.5
256
350
R03DC01
ATC
zafirlukast; oral
42.7
109.0
136
35
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
28.8
107.9
148
57
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
10.7
107.2
218
236
TGC00
NOMESCO Finland
Bronchial lavation
14.6
105.2
183
142
R05
ICD-10 Finland
Cough
4.1
104.1
498
1629
51899
ICD-8 Finland
Bronchiectasis
110.3
103.6
112
11
R04.2
ICD-10 Finland
Haemoptysis
11.1
100.9
201
208
J01FA15
ATC
telithromycin; oral
5.9
100.5
316
660
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
7.9
98.6
242
359
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
+∞
98.0
93
*
R02
ICPC
Shortness of breath/dyspnoea
5.0
95.6
351
872
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
13.0
91.3
167
144
J01.0
ICD-10 Finland
Acute maxillary sinusitis
3.8
86.6
451
1546
R01AD01
ATC
beclometasone; nasal
4.4
86.3
366
1042
UDH02
NOMESCO Finland
Rhinopharyngoscopy
7.0
85.7
228
377
XQ800
NOMESCO Finland
Prick test
7.7
84.0
208
309
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
8.2
83.7
198
274
4940A
ICD-9 Finland
Bronchiectasis[BRONCHIECTASIAE]
290.6
81.4
82
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.9
75.1
647
3138
R05
ICPC
Cough
3.3
74.4
487
1954
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
10.8
74.2
148
151
GD1AD
NOMESCO Finland
Thorax CT examination
7.6
73.9
183
270
R06AE07
ATC
cetirizine; oral
2.8
72.7
736
3927
R01AD05
ATC
budesonide; nasal
5.6
72.2
228
466
J01CA04
ATC
amoxicillin; systemic
3.5
72.0
1235
9151
J20
ICD-10 Finland
Acute bronchitis
4.7
71.9
270
669
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
57.1
68.7
81
15
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
3.0
68.3
505
2180
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
3.5
67.6
376
1319
A01AB09
ATC
miconazole; local oral
4.6
67.1
261
667
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
8.1
67.0
158
215
4930A
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA SINE EXACERBATIONE]
+∞
66.1
63
*
A07AA02
ATC
nystatin; oral
5.2
65.3
219
477
J01MA02
ATC
ciprofloxacin; systemic
2.6
65.1
736
4094
R81
ICPC
Pneumonia
8.5
62.7
143
184
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
62.3
437
1800
B44.1
ICD-10 Finland
Other pulmonary aspergillosis
634.5
62.3
61
*
J32.4
ICD-10 Finland
Chronic pansinusitis
26.9
60.6
84
33
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
11.0
60.1
118
116
R01AD12
ATC
fluticasone furoate; nasal
2.8
59.3
476
2128
A02BC02
ATC
pantoprazole; systemic
2.6
58.5
1063
7481
R06.2
ICD-10 Finland
Wheezing
9.1
58.3
127
151
J31.0
ICD-10 Finland
Chronic rhinitis
4.9
55.9
196
445
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
8.6
55.8
126
159
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
55.8
676
3797
R01BA52
ATC
pseudoephedrine, combinations; oral
2.6
55.4
561
2852
J40
ICD-10 Finland
Bronchitis, not specified as acute or chronic
9.1
55.0
120
143
R06AX27
ATC
desloratadine; oral
2.8
54.0
422
1838
4930B
ICD-9 Finland
Asthma, Extrinsic asthma[EXTRINSIC ASTHMA CUM EXACERBATIONE]
+∞
53.5
51
*
A02BC05
ATC
esomeprazole; systemic
2.4
52.3
704
4127
J02AC01
ATC
fluconazole; systemic
2.4
52.0
650
3667
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
12.5
51.8
95
81
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
+∞
51.4
49
*
J33.0
ICD-10 Finland
Polyp of nasal cavity
11.0
50.7
99
96
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.3
50.5
206
542
R03BC03
ATC
nedocromil; inhalant
4.5
49.6
189
465
J01DA06
ATC
[U] cefuroxime; systemic
3.1
48.3
303
1129
A03
ICPC
Fever
3.3
48.2
280
988
SPAT1325
SPAT
Vaccination
2.3
46.2
661
3914
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.9
45.7
205
586
C03CA01
ATC
furosemide; systemic
2.3
45.5
578
3222
WW200
NOMESCO Finland
Immunization
7.9
44.8
106
144
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
8.4
44.5
101
128
XG405
NOMESCO Finland
Education on PEF monitoring
19.5
43.9
67
36
J01DB01
ATC
cefalexin; oral
2.6
43.7
1215
9710
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
43.7
348
1504
ZXA10
NOMESCO Finland
Bilateral
2.6
43.3
390
1809
A01AB04
ATC
amphotericin B; local oral
5.0
42.9
147
322
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
42.6
531
2907
J96.1
ICD-10 Finland
Chronic respiratory failure
9.9
42.3
87
93
G47.3
ICD-10 Finland
Sleep apnoea
2.7
42.1
344
1505
J01DA01
ATC
[U] cefalexin; systemic
2.2
42.0
957
6863
A02BC01
ATC
omeprazole; systemic
2.3
41.8
506
2729
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.5
41.4
210
663
R50.9
ICD-10 Finland
Fever, unspecified
3.0
41.1
275
1059
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
40.2
398
1929
4931B
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA CUM EXACERBATIONE]
+∞
39.8
38
*
R05DA20
ATC
opium alkaloids and derivatives - combinations
2.3
39.7
450
2335
J01DA08
ATC
[U] cefaclor; oral
3.5
39.0
197
618
R06AX13
ATC
loratadine; oral
3.0
38.9
260
996
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
15.6
38.2
63
42
C01CA24
ATC
epinephrine; parenteral
5.2
38.1
123
252
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
10.4
38.1
76
77
49302
ICD-8 Finland
Asthma, Rhinitis allergica cum asthmate bronchiali
+∞
37.7
36
*
N02AX02
ATC
tramadol; systemic, rectal
2.1
37.6
691
4428
R4110
NOMESCO Finland
Physiotherapy
2.2
37.2
472
2569
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
84.4
37.0
41
5
A02BC03
ATC
lansoprazole; oral
2.2
36.7
517
2950
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
36.3
236
887
J42
ICD-10 Finland
Unspecified chronic bronchitis
12.8
36.2
65
53
R74
ICPC
Upper respiratory infection acute
2.4
36.2
384
1914
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
80.2
35.0
39
5
R5140
NOMESCO Finland
Monitoring the use of the aid
3.2
35.0
203
705
M05BA04
ATC
alendronic acid; oral
3.0
34.7
226
847
J01DC02
ATC
cefuroxime; systemic
4.5
34.5
130
313
WZC30
NOMESCO Finland
Teaching
2.7
34.4
262
1085
R03BC01
ATC
cromoglicic acid; inhalant
17.5
34.3
54
32
R06AE09
ATC
levocetirizine; oral
2.9
34.2
238
932
H02AB09
ATC
hydrocortisone; systemic
8.0
34.0
79
104
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.3
32.5
126
312
J01GB01
ATC
tobramycin; inhalant, parenteral
323.9
32.0
32
*
4859X
ICD-9 Finland
Bronchopneumonia, organism unspecified[PNEUMONIA NUD]
8.3
31.8
72
91
120
Kela drug reimbursment
Hypogammaglobulinaemia
168.7
31.8
33
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.5
31.8
297
1376
S01GX01
ATC
cromoglicic acid; ophthalmic
2.5
31.7
296
1368
R05CB01
ATC
acetylcysteine; inhalant, oral
8.6
31.7
70
85
R05FB02
ATC
cough suppressants and expectorants
2.0
31.6
629
4068
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
9.9
31.6
64
67
B05XA03
ATC
sodium chloride; parenteral
+∞
31.4
30
*
N02BE01
ATC
paracetamol; systemic, rectal
2.5
31.3
1275
10897
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
14.4
31.3
53
38
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.4
31.3
160
504
R06AX22
ATC
ebastine; oral
2.6
31.0
267
1179
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
163.5
30.8
32
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
30.7
299
1408
J01FF01
ATC
clindamycin; systemic
2.1
30.5
438
2476
R01AD11
ATC
triamcinolone; nasal
3.4
30.2
160
517
J41.1
ICD-10 Finland
Mucopurulent chronic bronchitis
21.6
30.1
44
21
R06AX26
ATC
fexofenadine; oral
4.0
30.0
125
331
R95
ICPC
Chron obstructive pulmonary disease
6.2
29.8
82
138
J33.8
ICD-10 Finland
Other polyp of sinus
8.9
29.7
64
75
A02BA02
ATC
ranitidine; systemic
2.2
29.4
361
1901
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.3
29.3
329
1660
C07AB07
ATC
bisoprolol; oral
1.9
29.0
778
5544
J15.1
ICD-10 Finland
Pneumonia due to Pseudomonas
81.9
28.8
32
*
R03BB02
ATC
oxitropium bromide; inhalant
19.2
28.4
43
23
R05FA02
ATC
opium derivatives and expectorants; systemic
1.9
28.1
627
4167
50301
ICD-8 Finland
Chronic sinusitis, Maxillaris NUD
12.6
27.9
50
41
R29
ICPC
Respiratory symptom/complaint other
3.7
27.8
130
380
SPAT1254
SPAT
Administration of medicine
2.4
27.7
279
1333
R07.4
ICD-10 Finland
Chest pain, unspecified
2.0
27.6
453
2682
A46
ICD-10 Finland
Erysipelas
2.4
27.5
259
1197
R28
ICPC
Limited function/disability (R)
9.1
27.4
58
66
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
63.3
27.0
31
5
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
15.6
26.9
44
29
H65.2
ICD-10 Finland
Chronic serous otitis media
14.6
26.2
44
31
J01XB01
ATC
colistin; inhalant, parenteral
+∞
26.1
25
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
25.9
673
4675
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
6.1
25.6
71
121
DHB20
NOMESCO Finland
Polypectomy of internal nose
12.9
25.4
45
36
XG466
NOMESCO Finland
Sleep oxymetry
5.0
25.2
83
174
UDM02
NOMESCO Finland
Sinoscopy
6.3
25.0
68
113
E0000UV
ATC
NA
1.8
24.8
573
3806
R78
ICPC
Acute bronchitis/bronchiolitis
6.4
24.8
66
107
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
6.3
24.4
66
109
N03AX16
ATC
pregabalin; oral
2.0
24.1
379
2187
H65.3
ICD-10 Finland
Chronic mucoid otitis media
8.4
24.0
53
65
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.3
23.8
258
1269
J15.8
ICD-10 Finland
Other bacterial pneumonia
17.2
23.6
37
22
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
23.6
289
1499
XG404
NOMESCO Finland
Peak expiratory flow (PEF) measurement
36.9
23.0
29
8
SPAT1263
SPAT
Sampling
1.8
23.0
645
4533
4939A
ICD-9 Finland
Asthma, unspecified[ASTHMA ALIA DEFINITA SINE EXACERBATIONE]
+∞
23.0
22
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
22.7
244
1192
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
4.6
22.7
81
185
R03BB07
ATC
umeclidinium bromide; inhalant
14.4
22.7
38
27
ZX120
NOMESCO Finland
Intravenous
2.6
22.6
179
749
J30.3
ICD-10 Finland
Other allergic rhinitis
6.1
22.4
62
106
SPAT1255
SPAT
Intravenous administration of medicine
3.0
22.2
136
485
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
12.5
21.9
39
32
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
6.4
21.8
58
94
49099
ICD-8 Finland
Bronchitis, unspecified
11.1
21.7
41
38
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
8.2
21.5
48
60
Z71.8
ICD-10 Finland
Other specified counselling
2.0
21.5
333
1898
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
5.1
21.2
68
139
R03AK
ATC
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
28.5
21.0
28
10
N03AX12
ATC
gabapentin; oral
2.1
20.9
253
1301
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.5
20.9
183
807
B44.8
ICD-10 Finland
Other forms of aspergillosis
+∞
20.9
20
*
S18
ICPC
Laceration/cut
1.7
20.8
641
4585
R60.0
ICD-10 Finland
Localized oedema
2.3
20.8
205
959
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.1
20.8
120
411
1240
FHL
Bronchoscopy
9.2
20.7
43
48
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.5
20.2
164
692
J02AC03
ATC
voriconazole; systemic
48.7
20.2
24
5
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
5.0
20.0
65
135
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
20.0
645
4659
A31.9
ICD-10 Finland
Mycobacterial infection, unspecified
74.5
19.7
22
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
7.8
19.7
45
59
J01FA01
ATC
erythromycin; systemic
2.3
19.6
197
931
J18.1
ICD-10 Finland
Lobar pneumonia, unspecified
8.9
19.4
41
47
4222
FHL
Endonasal etmoidectomy
14.8
19.4
32
22
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.9
19.3
347
2079
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.8
19.3
381
2359
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
19.3
190
888
R99
ICPC
Respiratory disease other
6.6
19.1
49
76
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
20.4
19.1
28
14
R01AC01
ATC
cromoglicic acid; nasal
4.5
18.9
68
157
N05CF01
ATC
zopiclone; oral
1.7
18.9
501
3401
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.7
18.8
553
3866
49109
ICD-8 Finland
Chronic bronchitis, Unspecified
24.0
18.7
26
11
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
101.4
18.6
20
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
18.5
238
1254
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.6
18.4
141
575
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
30.5
18.4
24
8
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.2
18.1
192
927
L17
ICPC
Foot/toe symptom/complaint
1.8
18.1
385
2433
J37.0
ICD-10 Finland
Chronic laryngitis
4.2
18.1
69
169
XG480
NOMESCO Finland
Histamine provocation of respiratroy tract
11.6
18.0
33
29
J34.2
ICD-10 Finland
Deviated nasal septum
3.6
18.0
84
246
J32.8
ICD-10 Finland
Other chronic sinusitis
33.4
18.0
23
7
6BA02
NOMESCO Finland
NA
33.4
18.0
23
7
J13
ICD-10 Finland
Pneumonia due to Streptococcus pneumoniae
9.7
17.9
36
38
M79.6
ICD-10 Finland
Pain in limb
1.7
17.9
517
3585
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.6
17.9
63
143
E000001
ATC
NA
1.9
17.9
291
1675
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
5.1
17.7
56
113
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
17.7
484
3298
R05CA10
ATC
expectorants - combinations
5.2
17.7
55
109
WX892
NOMESCO Finland
Monitored bed care
2.5
17.5
139
580
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.8
17.4
379
2409
J98.0
ICD-10 Finland
Diseases of bronchus, not elsewhere classified
17.2
17.4
27
16
J43.9
ICD-10 Finland
Emphysema, unspecified
6.6
17.3
44
68
R09
ICPC
Sinus symptom/complaint
2.8
17.1
116
440
348
Kela drug reimbursment
Roflumilast
31.9
17.1
22
7
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.5
16.9
135
565
P01AB01
ATC
metronidazole; oral, rectal
1.6
16.8
538
3825
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
16.7
393
2553
R09.3
ICD-10 Finland
Abnormal sputum
9.4
16.7
34
37
O99.5
ICD-10 Finland
Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium
171.9
16.5
17
*
A03FA02
ATC
cisapride; oral, rectal
2.4
16.5
141
611
J01.1
ICD-10 Finland
Acute frontal sinusitis
9.1
16.5
34
38
4711A
ICD-9 Finland
Nasal polyps, Polypoid sinus degeneration
20.3
16.4
24
12
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
5.1
16.4
52
106
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
16.1
342
2151
49101
ICD-8 Finland
Chronic bronchitis, Nonpurulenta (simplex)
24.8
16.0
22
9
R49.01
ICD-10 Finland
Functional dysphonia
4.1
16.0
62
155
L28
ICPC
Limited function/disability (L)
1.9
15.9
282
1667
4900A
ICD-9 Finland
Bronchitis, not specified as acute or chronic[BRONCHITIS NUD]
14.7
15.9
26
18
R05CB03
ATC
carbocisteine; oral
4.7
15.8
54
119
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
15.8
450
3083
49102
ICD-8 Finland
Chronic bronchitis, Purulenta
33.8
15.7
20
6
DPA30
NOMESCO Finland
Sphenotomy
15.9
15.7
25
16
3028
Kela drug reimbursment
Mepolizumab
+∞
15.6
15
*
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
15.6
257
1480
J01.9
ICD-10 Finland
Acute sinusitis, unspecified
4.1
15.6
61
154
A01AB10
ATC
natamycin; local oral
4.1
15.6
61
154
B96.5
ICD-10 Finland
Pseudomonas (aeruginosa) as the cause of diseases classified to other chapters
86.0
15.6
17
*
XF600
NOMESCO Finland
Bloodpressure measurement
2.6
15.5
114
454
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
15.4
194
1006
WX725
NOMESCO Finland
Noninvasive ventilation
3.2
15.4
82
267
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
15.3
294
1784
R05CB02
ATC
bromhexine; systemic
5.8
15.3
43
76
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
15.3
213
1152
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.4
15.2
136
605
J05AH02
ATC
oseltamivir; oral
18.0
15.2
23
13
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.2
15.1
82
270
R79
ICPC
Chronic bronchitis
23.6
15.1
21
9
J82
ICD-10 Finland
Pulmonary eosinophilia, not elsewhere classified
23.6
15.1
21
9
Y0499
ICD-8 Finland
Investigation of respiratory system
7.4
15.0
35
48
4779A
ICD-9 Finland
Allergic rhinitis, Cause unspecified
10.2
15.0
29
29
N06AX11
ATC
mirtazapine; oral
1.7
14.9
426
2910
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.1
14.8
171
853
WX722
NOMESCO Finland
PEEP
3.0
14.8
86
297
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
10.6
14.7
28
27
J98.1
ICD-10 Finland
Pulmonary collapse
10.6
14.7
28
27
D72.1
ICD-10 Finland
Eosinophilia
25.3
14.7
20
8
J32.1
ICD-10 Finland
Chronic frontal sinusitis
25.3
14.7
20
8
N06AB04
ATC
citalopram; systemic
1.8
14.6
302
1872
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
14.6
14
*
297
Kela drug reimbursment
NA
+∞
14.6
14
*
R03DX09
ATC
mepolizumab; parenteral
+∞
14.6
14
*
B90.9
ICD-10 Finland
Sequelae of respiratory and unspecified tuberculosis
12.0
14.6
26
22
C08DA01
ATC
verapamil; systemic
3.0
14.5
83
284
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
14.5
524
3804
F2680
NOMESCO Finland
NA
36.4
14.5
18
5
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
36.4
14.5
18
5
4239
FHL
Other measure in this category
15.6
14.4
23
15
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.7
14.3
100
387
TPH07
NOMESCO Finland
Cathetrisation of artery
2.1
14.3
168
847
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.4
14.3
130
583
R24
ICPC
Haemoptysis
10.6
14.2
27
26
R03AC04
ATC
fenoterol; inhalant
22.5
14.2
20
9
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
9.2
14.2
29
32
J10.1
ICD-10 Finland
Influenza with other respiratory manifestations, seasonal influenza virus identified
5.4
14.1
42
80
48609
ICD-8 Finland
Pneumonia, unspecified
6.7
14.1
35
53
R03DA54
ATC
theophylline, combinations excl. psycholeptics; systemic
6.7
14.1
35
53
RK250
NOMESCO Finland
NA
14.6
14.1
23
16
R49.08
ICD-10 Finland
Other specified dysphonia
4.7
14.1
47
102
R75
ICPC
Sinusitis acute/chronic
3.2
13.9
73
236
R53
ICD-10 Finland
Malaise and fatigue
1.8
13.8
298
1867
R03AC18
ATC
indacaterol; inhalant
11.5
13.8
25
22
A44
ICPC
General and Unspecified, Preventive immunization/medic
2.3
13.8
125
560
N02AA05
ATC
oxycodone; systemic
1.8
13.8
242
1423
A02BA04
ATC
nizatidine; systemic
2.2
13.7
137
643
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
14.9
13.6
22
15
B44.0
ICD-10 Finland
Invasive pulmonary aspergillosis
+∞
13.6
13
*
4939B
ICD-9 Finland
Asthma, unspecified[ASTHMA ALIA DEFINITA CUM EXACERBATIONE]
+∞
13.6
13
*
J96.0
ICD-10 Finland
Acute respiratory failure
5.2
13.5
41
80
M25.5
ICD-10 Finland
Pain in joint
1.7
13.5
369
2480
WX002
NOMESCO Finland
Sedation and analgesia
1.7
13.5
304
1930
UJF32
NOMESCO Finland
Coloscopy
1.6
13.5
389
2651
4224
FHL
Endonasal anthrostomy
7.8
13.4
30
39
R03DX07
ATC
roflumilast; oral
26.0
13.4
18
7
N06AX21
ATC
duloxetine; oral
2.2
13.3
143
693
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.7
13.3
93
360
I45.9
ICD-10 Finland
Conduction disorder, unspecified
9.1
13.2
27
30
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
13.2
441
3117
46100
ICD-8 Finland
Acute sinusitis, Maxillaris
5.2
13.2
40
78
RF410
NOMESCO Finland
NA
5.9
13.2
36
62
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
13.2
147
725
UGC02
NOMESCO Finland
Rigid bronchoscopy
40.5
13.2
16
*
B37.0
ICD-10 Finland
Candidal stomatitis
8.0
13.1
29
37
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
13.0
607
4650
N06AA09
ATC
amitriptyline; systemic
2.1
13.0
158
805
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
3.0
13.0
74
252
UDC00
NOMESCO Finland
Ear microscopy
2.3
13.0
119
535
H25.1
ICD-10 Finland
Senile nuclear cataract
1.6
13.0
433
3060
ZXA00
NOMESCO Finland
Right side
1.6
12.9
412
2877
48509
ICD-8 Finland
Bronchopneumonia, unspecified
7.0
12.9
31
45
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
12.9
205
1159
D07AA02
ATC
hydrocortisone; topical
2.0
12.9
179
963
N02AJ06
ATC
codeine and paracetamol; systemic
1.6
12.8
482
3507
4226
FHL
Posterior radical surgery and possible etmoidectomy
8.6
12.8
27
32
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
9.1
12.7
26
29
L03
ICPC
Low back symptom/complaint
1.7
12.7
336
2235
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
12.6
366
2491
SPAT1260
SPAT
Consultation of another employee
1.7
12.5
274
1720
Q89.34
ICD-10 Finland
Cartagena syndrome (immotile cilia)
+∞
12.5
12
*
J20.0
ICD-10 Finland
Acute bronchitis due to Mycoplasma pneumoniae
8.8
12.5
26
30
E88.0
ICD-10 Finland
Disorders of plasma-protein metabolism, not elsewhere classified
24.5
12.5
17
7
E000007
ATC
NA
2.7
12.4
86
333
M54.5
ICD-10 Finland
Low back pain
1.6
12.4
420
2974
N05BA01
ATC
diazepam; systemic, rectal
1.9
12.3
188
1046
SAA01
NOMESCO Finland
Simple examination of mouth
1.5
12.3
871
7271
M05BA07
ATC
risedronic acid; oral
2.9
12.3
76
274
RK110
NOMESCO Finland
NA
8.5
12.3
26
31
R42
ICD-10 Finland
Dizziness and giddiness
1.6
12.3
332
2216
J01DC04
ATC
cefaclor; oral
6.8
12.2
30
45
RF210
NOMESCO Finland
NA
3.5
12.2
56
164
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.1
12.1
139
695
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
12.0
523
3926
R03
ICPC
Wheezing
7.6
11.9
27
36
DJD20
NOMESCO Finland
Plastic repair of septum of nose
3.5
11.9
55
162
RK320
NOMESCO Finland
NA
8.0
11.9
26
33
4610A
ICD-9 Finland
Acute sinusitis, Maxillary
7.1
11.8
28
40
DHB50
NOMESCO Finland
Turbinoplasty
4.4
11.8
42
98
T78.4
ICD-10 Finland
Allergy, unspecified
3.1
11.8
65
218
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
11.8
323
2163
R83
ICPC
Respiratory infection other
1.8
11.7
231
1403
S81.0
ICD-10 Finland
Open wound of knee
6.4
11.7
30
48
R51.80
ICD-10 Finland
Headache
1.9
11.7
181
1012
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
11.7
110
499
J01MA11
ATC
grepafloxacin; oral
30.3
11.6
15
5
ZXA05
NOMESCO Finland
Left side
1.6
11.6
380
2662
R06.5
ICD-10 Finland
Mouth breathing
2.3
11.6
113
525
SPAT1058
SPAT
PEF monitoring instruction
2.2
11.6
120
573
J01MA01
ATC
ofloxacin; systemic
2.1
11.5
139
705
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
11.5
11
*
R04
ICPC
Breathing problem other
3.4
11.4
54
162
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
120.9
11.4
12
*
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.9
11.4
46
121
-1
NOMESCO Finland
NA
1.6
11.4
400
2846
G44.2
ICD-10 Finland
Tension-type headache
1.9
11.4
168
926
WX110
NOMESCO Finland
Local anesthesy
1.5
11.4
874
7365
R03AC19
ATC
olodaterol; inhalant
11.9
11.3
20
17
XG499
NOMESCO Finland
Other fysiological examination of respiatory function
15.2
11.3
18
12
N05BA04
ATC
oxazepam; oral
1.6
11.3
331
2252
J33.9
ICD-10 Finland
Nasal polyp, unspecified
8.4
11.3
24
29
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
11.3
269
1728
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
6.6
11.3
28
43
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
11.2
225
1371
A06AD11
ATC
lactulose; oral
1.8
11.2
228
1396
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.1
11.2
60
198
69100
ICD-8 Finland
Infantile eczema and related conditions, Eczema atopicum. Prurigo Besnier. Eczema pruriginosum allergicum
6.9
11.2
27
40
H66.0
ICD-10 Finland
Acute suppurative otitis media
2.8
11.2
73
272
RF420
NOMESCO Finland
NA
5.1
11.1
34
68
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
4.2
11.1
41
100
I50.0
ICD-10 Finland
Congestive heart failure
2.2
11.0
120
583
R03BB05
ATC
aclidinium bromide; inhalant
14.0
11.0
18
13
50300
ICD-8 Finland
Chronic sinusitis, Maxillaris cum empyemate
14.0
11.0
18
13
J01
ICD-10 Finland
Acute sinusitis
2.9
11.0
68
246
RS221
NOMESCO Finland
NA
5.8
10.9
30
53
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
4.1
10.8
41
102
A15.0
ICD-10 Finland
Tuberculosis of lung, confirmed by sputum microscopy with or without culture
12.0
10.8
19
16
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.4
10.8
95
420
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
5.4
10.8
31
58
49104
ICD-8 Finland
Chronic bronchitis, Cum emphysemate
28.2
10.7
14
5
Q32.21
ICD-10 Finland
Secondary congenital bronchomalacia
21.6
10.7
15
7
4732A
ICD-9 Finland
Chronic sinusitis, Ethmoidal
21.6
10.7
15
7
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.3
10.7
94
416
J18
ICD-10 Finland
Pneumonia, organism unspecified
7.6
10.7
24
32
Z96.1
ICD-10 Finland
Presence of intraocular lens
1.7
10.7
223
1376
N05BB01
ATC
hydroxyzine; systemic
2.4
10.6
87
370
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
10.6
169
957
M05BX04
ATC
denosumab; parenteral
2.3
10.5
101
466
L95
ICPC
Osteoporosis
2.7
10.5
71
272
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
3.3
10.5
51
157
R11
ICD-10 Finland
Nausea and vomiting
2.1
10.4
123
620
B44.9
ICD-10 Finland
Aspergillosis, unspecified
110.8
10.4
11
*
49309
ICD-8 Finland
Asthma, Unspecified
+∞
10.4
10
*
S97
ICPC
Chronic ulcer skin
2.3
10.4
92
408
S22.3
ICD-10 Finland
Fracture of rib
2.3
10.4
95
429
J05AB11
ATC
valaciclovir; oral
1.8
10.4
186
1095
4660A
ICD-9 Finland
Acute bronchitis and bronchiolitis, Acute bronchitis
9.6
10.3
20
21
M03BX02
ATC
tizanidine; oral
1.4
10.1
762
6325
L14
ICPC
Leg/thigh symptom/complaint
2.1
10.1
116
576
R13
ICD-10 Finland
Dysphagia
2.3
10.1
97
445
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.6
10.1
72
286
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
9.2
10.0
20
22
W22
ICD-10 Finland
Striking against or struck by other object(s)
2.5
10.0
75
306
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
3.9
9.9
39
101
R03CC02
ATC
salbutamol; systemic
3.1
9.9
54
181
A28
ICPC
Limited function/disability NOS
1.7
9.9
247
1603
SPAT1059
SPAT
Spirometry at the office
2.4
9.9
80
338
L88
ICPC
Rheumatoid/seropositive arthritis
2.7
9.9
66
250
4221
FHL
Polyp removal from the nasal cavity, sinus puncture or irrigation, or biopsy under general anesthesia or operating room
12.3
9.9
17
14
TKC20
NOMESCO Finland
Catheterisation of bladder
2.1
9.9
112
556
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
3.7
9.8
42
117
SPAT1262
SPAT
Handing over of treatment supplies
1.6
9.8
265
1756
D20
ICPC
Mouth/tongue/lip symptom/complaint
2.6
9.8
70
277
N06AB10
ATC
escitalopram; oral
1.7
9.8
212
1320
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.2
9.8
98
461
J41.0
ICD-10 Finland
Simple chronic bronchitis
8.8
9.8
20
23
R4190
NOMESCO Finland
Nutritional therapy
3.3
9.8
47
144
J12.9
ICD-10 Finland
Viral pneumonia, unspecified
10.7
9.8
18
17
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.1
9.8
114
574
A04
ICPC
Weakness/tiredness general
1.8
9.7
186
1118
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.6
9.7
72
290
JN4BD
NOMESCO Finland
Extensive body CT
1.8
9.7
172
1007
RF120
NOMESCO Finland
NA
5.2
9.7
29
57
M48.0
ICD-10 Finland
Spinal stenosis
1.8
9.7
190
1148
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.4
9.7
46
140
R35
ICD-10 Finland
Polyuria
2.2
9.7
97
457
H53.1
ICD-10 Finland
Subjective visual disturbances
2.3
9.7
92
423
SPAT1310
SPAT
Counselling related to known health issue
1.5
9.6
427
3183
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.8
9.6
159
909
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
4.9
9.6
30
62
B01AB05
ATC
enoxaparin; parenteral
1.5
9.6
435
3253
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.9
9.5
140
770
Z94.2
ICD-10 Finland
Lung transplant status
100.7
9.4
10
*
L04AX01
ATC
azathioprine; systemic
2.7
9.4
64
247
R03DA74
ATC
theophylline, combinations with psycholeptics; systemic
30.2
9.4
12
*
E27.4
ICD-10 Finland
Other and unspecified adrenocortical insufficiency
17.7
9.4
14
8
G01AF04
ATC
miconazole; vaginal
2.6
9.4
67
265
GDG10
NOMESCO Finland
Bilateral transplantation of lung
+∞
9.4
9
*
4911A
ICD-9 Finland
Chronic bronchitis, Mucopurulent chronic bronchitis
+∞
9.4
9
*
J20.8
ICD-10 Finland
Acute bronchitis due to other specified organisms
21.8
9.4
13
6
R03DB04
ATC
theophylline and adrenergics; systemic
21.8
9.4
13
6
UGC18
NOMESCO Finland
Flexible bronchoscopy with biopsy of lung
8.1
9.3
20
25
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.7
9.3
62
235
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.8
9.3
59
219
M02AA07
ATC
piroxicam; topical
1.4
9.3
526
4114
A92
ICPC
Allergy/allergic reaction NOS
4.1
9.3
35
88
J32.2
ICD-10 Finland
Chronic ethmoidal sinusitis
6.1
9.2
24
40
SPAT1216
SPAT
Assessment of functional ability
1.6
9.2
259
1735
SPAT1257
SPAT
Teaching of medicine inhalation technique
2.8
9.2
58
213
A02BX02
ATC
sucralfate; oral
2.5
9.2
69
280
J05AB01
ATC
aciclovir; systemic
1.6
9.2
280
1911
WX320
NOMESCO Finland
Spinalanesthesy
1.5
9.2
314
2204
WX872
NOMESCO Finland
Intensive care
2.4
9.2
76
327
D02AX
ATC
Other emollients and protectives
3.2
9.2
46
146
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.1
9.1
109
552
R01BA51
ATC
phenylpropanolamine, combinations; oral
1.9
9.1
142
797
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.8
9.0
145
822
UJD02
NOMESCO Finland
Gastroscopy
2.4
9.0
77
337
AA1AD
NOMESCO Finland
CT of head and brain
1.5
8.9
349
2527
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
8.9
204
1294
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.0
8.9
112
583
SAA02
NOMESCO Finland
Basic examination of mouth
1.4
8.9
759
6384
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.1
8.9
96
467
J01EA01
ATC
trimethoprim; systemic
1.5
8.9
351
2546
M01AH02
ATC
rofecoxib; oral
1.7
8.9
202
1279
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.7
8.8
57
214
H66.9
ICD-10 Finland
Otitis media, unspecified
2.6
8.8
63
250
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.9
8.8
121
651
S51.8
ICD-10 Finland
Open wound of other parts of forearm
6.0
8.8
23
39
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.1
8.8
93
449
P01BA02
ATC
hydroxychloroquine; oral
1.9
8.8
119
637
R07.3
ICD-10 Finland
Other chest pain
1.9
8.7
128
703
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.2
8.7
86
403
S21
ICPC
Skin texture symptom/complaint
1.7
8.7
175
1068
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
8.7
441
3365
R06AX12
ATC
terfenadine; oral
2.6
8.7
63
253
R01BA01
ATC
phenylpropanolamine; oral
2.3
8.7
80
362
J86.9
ICD-10 Finland
Pyothorax without fistula
6.6
8.7
21
32
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.3
8.6
78
351
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.0
8.6
108
560
C01DA14
ATC
isosorbide mononitrate; oral
1.6
8.6
234
1552
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.9
8.6
133
746
B01AF02
ATC
apixaban; oral
1.8
8.6
157
929
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.8
8.6
34
90
7860A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Dyspnoea and respiratory abnormalities[DYSPNOEA]
7.0
8.6
20
29
J30.4
ICD-10 Finland
Allergic rhinitis, unspecified
3.3
8.5
40
122
M70.6
ICD-10 Finland
Trochanteric bursitis
1.7
8.5
181
1124
C03DA01
ATC
spironolactone; oral
1.8
8.4
156
926
J02AC02
ATC
itraconazole; systemic
1.6
8.4
238
1594
R60.9
ICD-10 Finland
Oedema, unspecified
2.4
8.4
71
309
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.8
8.4
147
855
A16.0
ICD-10 Finland
Tuberculosis of lung, bacteriologically and histologically negative
90.6
8.4
9
*
R4120
NOMESCO Finland
Occupational therapy
2.2
8.4
88
422
R01AC07
ATC
nedocromil; nasal
12.8
8.4
14
11
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.7
8.4
197
1255
E66.01
ICD-10 Finland
Obesity due to excess calories
2.2
8.4
79
364
E84.0
ICD-10 Finland
Cystic fibrosis with pulmonary manifestations
+∞
8.3
8
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.6
8.3
60
239
N02AC04
ATC
dextropropoxyphene; oral
2.5
8.3
63
258
7862A
ICD-9 Finland
Symptoms involving respiratory system and other chest symptoms, Cough
7.1
8.3
19
27
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.8
8.3
144
839
A41.9
ICD-10 Finland
Sepsis, unspecified
2.6
8.2
60
241
N06AX16
ATC
venlafaxine; oral
1.8
8.2
146
857
L16
ICPC
Ankle symptom/complaint
1.8
8.2
130
735
Z50.1
ICD-10 Finland
Other physical therapy
2.1
8.2
87
420
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.8
8.2
50
182
B01AA03
ATC
warfarin; systemic
1.5
8.2
304
2168
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.6
8.2
238
1604
A01
ICPC
Pain general/multiple sites
1.9
8.2
114
616
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.7
8.1
52
195
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.4
8.1
662
5489
E000002
ATC
NA
1.8
8.1
130
736
M30.1
ICD-10 Finland
Polyarteritis with lung involvement [Churg-Strauss]
33.5
8.1
10
*
B01AC04
ATC
clopidogrel; oral
1.6
8.1
234
1573
L04AA01
ATC
[U] ciclosporin; systemic
4.9
8.1
25
52
D86.0
ICD-10 Finland
Sarcoidosis of lung
4.9
8.1
25
52
50503
ICD-8 Finland
Nasal polyp, Ethmoidalis
17.3
8.1
12
7
SPAT1036
SPAT
Maxillary puncture
11.8
8.1
14
12
P03
ICPC
Feeling depressed
2.1
8.1
88
430
SPAT1301
SPAT
No procedures
1.4
8.1
441
3402
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
8.0
203
1319
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
9.0
8.0
16
18
R01AD
ATC
Corticosteroids
5.1
8.0
24
48
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
8.0
142
830
J01.4
ICD-10 Finland
Acute pansinusitis
10.1
8.0
15
15
R03DA05
ATC
aminophylline; systemic, rectal
6.3
8.0
20
32
K02.1
ICD-10 Finland
Caries of dentine
1.4
8.0
652
5400
C08DB01
ATC
diltiazem; oral
2.1
8.0
90
448
M01AB55
ATC
diclofenac, combinations; oral
1.9
7.9
110
591
A99
ICPC
Disease/condition unspecnature/site
1.9
7.9
116
638
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
7.9
255
1763
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.2
7.9
80
379
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.0
7.9
96
493
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.4
7.9
657
5459
L12
ICPC
Hand/finger symptom/complaint
1.7
7.9
175
1096
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.4
7.9
64
274
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.7
7.8
173
1082
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.3
7.8
69
307
M79.1
ICD-10 Finland
Myalgia
1.7
7.8
162
999
M54.4
ICD-10 Finland
Lumbago with sciatica
1.6
7.8
196
1274
R43
ICPC
Respiratory, Other diagnostic procedure
7.0
7.8
18
26
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.1
7.8
86
424
H01
ICPC
Ear pain/earache
1.9
7.7
120
673
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.5
7.7
246
1694
J43.1
ICD-10 Finland
Panlobular emphysema
45.2
7.7
9
*
78559
ICD-8 Finland
Symptoms referable to abdomen and lower gastro-intestinal tract, Colica abdominalis NUD
2.8
7.7
47
172
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.9
7.7
116
644
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.7
7.6
144
861
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
4.8
7.6
24
51
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
6.7
7.6
18
27
Z00.0
ICD-10 Finland
General medical examination
1.5
7.6
240
1647
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.8
7.6
48
177
SPAT1252
SPAT
Overall medication plan or its review
1.9
7.5
107
581
SPAT1060
SPAT
Administration of oxygen
10.1
7.5
14
14
G04CA02
ATC
tamsulosin; oral
1.5
7.5
283
2020
DHA10
NOMESCO Finland
Biopsy of cavity of nose
5.8
7.5
20
35
SPAT1342
SPAT
Referral to specialised care
4.7
7.5
24
52
SPAT1057
SPAT
Peak expiratory flow measurement
3.3
7.5
36
112
D01
ICPC
Abdominal pain/cramps general
1.8
7.5
127
734
AN1
HP
Coronary angiography
1.6
7.5
176
1122
N05AH04
ATC
quetiapine; oral
1.7
7.4
171
1085
ZX114
NOMESCO Finland
Intramuscular
4.3
7.4
26
62
C09CA01
ATC
losartan; oral
1.5
7.4
332
2458
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
3.5
7.4
32
92
-44
ICPC
Preventive immunization/medic
1.8
7.4
135
801
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.5
7.4
302
2197
R23.3
ICD-10 Finland
Spontaneous ecchymoses
3.2
7.4
36
114
XW000
NOMESCO Finland
Bone marrow biopsy
2.3
7.3
66
296
S01
ICPC
Pain/tenderness of skin
2.3
7.3
67
305
A02BC04
ATC
rabeprazole; oral
1.9
7.3
109
603
251
Kela drug reimbursment
NA
+∞
7.3
7
*
M36.8*D80.1
ICD-10 Finland
Systemic disorders of connective tissue in hypogammaglobulinaemia
+∞
7.3
7
*
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
7.3
7
*
49308
ICD-8 Finland
Asthma, Alia definita
+∞
7.3
7
*
3027
Kela drug reimbursment
Benralizumab
+∞
7.3
7
*
D80.6
ICD-10 Finland
Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinaemia
+∞
7.3
7
*
R03DX10
ATC
benralizumab; systemic
+∞
7.3
7
*
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.3
224
1528
M54.2
ICD-10 Finland
Cervicalgia
2.1
7.2
82
410
R01AC02
ATC
levocabastine; nasal
3.2
7.2
36
116
J30.0
ICD-10 Finland
Vasomotor rhinitis
2.9
7.2
42
150
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
30.2
7.1
9
*
S01GX02
ATC
levocabastine; ophthalmic
2.1
7.1
73
350
SPAT1131
SPAT
Colonoscopy
2.5
7.1
54
224
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
7.1
388
2980
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
1.9
7.1
94
498
M05BA06
ATC
ibandronic acid; systemic
3.0
7.1
39
134
N05CD07
ATC
temazepam; oral
1.6
7.1
180
1169
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.4
7.1
562
4603
78329
ICD-8 Finland
Symptoms referable to respiratory system, Dyspnoea alia sive NUD
8.0
7.1
15
19
J11.0
ICD-10 Finland
Influenza with pneumonia, virus not identified
8.0
7.1
15
19
SPAT1028
SPAT
Ultrasound examination of paranasal sinuses
2.2
7.1
67
308
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
3.1
7.1
37
123
SPAT1104
SPAT
Monitoring of emergency patient
1.9
7.1
98
531
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
7.1
306
2247
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.4
7.0
54
226
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
7.0
412
3204
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.4
7.0
622
5185
H11.3
ICD-10 Finland
Conjunctival haemorrhage
2.3
7.0
59
258
UJF30
NOMESCO Finland
Ileoscopy through colon
1.8
7.0
128
758
R06.4
ICD-10 Finland
Hyperventilation
4.2
7.0
25
61
M81.4
ICD-10 Finland
Drug-induced osteoporosis
7.0
7.0
16
23
RD210
NOMESCO Finland
NA
3.9
7.0
27
71
R01
ICPC
Pain respiratory system
3.9
7.0
27
71
46699
ICD-8 Finland
Acute bronchitis and bronchiolitis
4.5
7.0
23
52
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.2
7.0
69
326
L05
ICPC
Flank/axilla symptom/complaint
2.1
7.0
74
361
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
6.9
326
2435
J04.0
ICD-10 Finland
Acute laryngitis
3.3
6.9
33
103
J01AA04
ATC
lymecycline; systemic
1.7
6.9
139
849
A07DA03
ATC
loperamide; oral
2.5
6.9
52
216
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
6.9
153
962
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
2.3
6.9
60
266
L02
ICPC
Back symptom/complaint
1.8
6.8
114
655
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.8
6.8
118
689
R03BB06
ATC
glycopyrronium bromide; inhalant
6.7
6.8
16
24
R48
ICPC
Respiratory, Clarification/discussion RFE/demand
9.4
6.8
13
14
KMAK
NOMESCO Finland
NA
1.3
6.8
591
4905
J41.8
ICD-10 Finland
Mixed simple and mucopurulent chronic bronchitis
40.2
6.8
8
*
F1246
NOMESCO Finland
NA
16.8
6.7
10
6
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.2
6.7
65
304
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
3.1
6.7
34
111
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
6.7
225
1566
XG460
NOMESCO Finland
Short time oxymetry
3.7
6.7
27
74
SPAT1211
SPAT
Application of soft bandage
1.7
6.7
127
763
S01GX04
ATC
nedocromil; ophthalmic
3.8
6.7
26
69
5AH02
NOMESCO Finland
NA
22.6
6.7
9
*
XG420
NOMESCO Finland
Time-volume spirometry
22.6
6.7
9
*
XF404
NOMESCO Finland
Ambulatory ECG
1.7
6.6
133
809
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
2.6
6.6
45
177
R03AL04
ATC
indacaterol and glycopyrronium bromide; inhalant
5.9
6.6
17
29
P01
ICPC
Feeling anxious/nervous/tense
2.0
6.6
86
454
DC1AD
NOMESCO Finland
Temporalbone CT
4.6
6.6
21
46
L50.0
ICD-10 Finland
Allergic urticaria
3.1
6.6
34
113
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
6.5
230
1618
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
4.4
6.5
22
51
RS220
NOMESCO Finland
NA
4.8
6.5
20
42
J43.8
ICD-10 Finland
Other emphysema
10.1
6.5
12
12
R5599
NOMESCO Finland
Other rehabilitation service
2.8
6.5
39
142
J34.3
ICD-10 Finland
Hypertrophy of nasal turbinates
3.5
6.5
28
81
S81.9
ICD-10 Finland
Open wound of lower leg, part unspecified
5.1
6.5
19
38
L04AD01
ATC
ciclosporin; systemic
4.0
6.5
24
61
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
4.0
6.5
24
61
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
1.6
6.5
149
943
A03CA02
ATC
clidinium and psycholeptics; oral
1.9
6.5
91
496
N06AX12
ATC
bupropion; oral
2.3
6.4
53
231
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
4.3
6.4
22
52
D84.1
ICD-10 Finland
Defects in the complement system
70.1
6.4
7
*
C01AA05
ATC
digoxin; systemic
1.7
6.4
126
764
N06AB03
ATC
fluoxetine; oral
1.6
6.4
144
909
L08
ICPC
Shoulder symptom/complaint
1.5
6.4
241
1719
SPAT1097
SPAT
Recording of ECG
1.5
6.4
211
1464
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
6.6
6.3
15
23
L01AA01
ATC
cyclophosphamide; systemic
8.2
6.3
13
16
D07AB02
ATC
hydrocortisone butyrate; topical
1.4
6.3
338
2579
M81.0
ICD-10 Finland
Postmenopausal osteoporosis
2.5
6.3
48
199
I45.0
ICD-10 Finland
Right fascicular block
5.5
6.3
17
31
D01BA02
ATC
terbinafine; oral; topical
1.4
6.3
310
2330
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
6.3
203
1400
J85.1
ICD-10 Finland
Abscess of lung with pneumonia
18.1
6.3
9
5
GD1BT
NOMESCO Finland
Biopsy of lung with X-ray guidance
+∞
6.3
6
*
A31.80
ICD-10 Finland
Oral infection caused by Mycobacterium intracellulare
+∞
6.3
6
*
R91
ICPC
CHRONIC BRONCHITIS
+∞
6.3
6
*
0310A
ICD-9 Finland
Diseases due to other mycobacteria, Pulmonary
+∞
6.3
6
*
5AB14
NOMESCO Finland
NA
26.8
6.2
8
*
XG467
NOMESCO Finland
Nocturnal CO2 monitoring
26.8
6.2
8
*
M03BC51
ATC
orphenadrine, combinations; systemic
1.4
6.2
318
2406
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.7
6.2
38
141
N03AE01
ATC
clonazepam; systemic
2.0
6.2
77
401
I20.00
ICD-10 Finland
Unstable angina
2.4
6.2
50
213
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
6.2
216
1513
N39.3
ICD-10 Finland
Stress incontinence
1.8
6.2
102
587
F34.1
ICD-10 Finland
Dysthymia
2.6
6.2
41
159
GDC00
NOMESCO Finland
Lobectomy of lung
5.0
6.2
18
36
D07AC01
ATC
betamethasone; topical
1.4
6.2
429
3423
RF220
NOMESCO Finland
NA
3.3
6.2
28
85
I45.1
ICD-10 Finland
Other and unspecified right bundle-branch block
6.3
6.2
15
24
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
2.5
6.2
45
185
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.4
6.1
404
3193
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.1
6.1
65
315
ND1AA
NOMESCO Finland
Wrist X-ray examination
1.9
6.1
86
467
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
4.0
6.1
22
55
J01AA07
ATC
tetracycline; systemic
1.6
6.1
162
1064
R03CC03
ATC
terbutaline; systemic
3.9
6.1
23
60
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
12.6
6.1
10
8
N17
ICPC
Vertigo/dizziness
1.6
6.1
156
1019
D64.9
ICD-10 Finland
Anaemia, unspecified
1.6
6.1
139
881
XJC00
NOMESCO Finland
Oesophageal manometry
8.6
6.1
12
14
N06AA10
ATC
nortriptyline; systemic
3.4
6.1
27
81
A02BA03
ATC
famotidine; systemic
2.2
6.0
58
272
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
6.0
199
1380
TQW40
NOMESCO Finland
Remowal of suture of skin
1.8
6.0
91
507
E000003
ATC
NA
2.2
6.0
57
263
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.4
6.0
46
192

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
593
137
67.05
307.65
5.4
2.2
—
—
—
0
0
592
525
17.04
307.65
2.3
1.1
280.8
177.1
u/ml
1.84
570
466
314
30
129.07
307.65
2.1
1.2
2.6
0.3
u/ml
5.27
237
12
189
99
21.43
245.88
1.5
1.3
—
—
—
0
0
186
96
21.71
243.50
1.4
1.3
6.7
7.3
g/l
0.53
133
69
186
96
21.71
243.50
1.4
1.3
0.4
0.4
g/l
0.73
134
69
186
96
21.71
243.50
1.4
1.3
2.8
2.8
g/l
0.07
131
70
220
177
14.19
229.23
6.6
2.4
—
—
—
0
0
426
820
6.66
222.35
1.9
1.3
—
—
—
0
0
461
967
6.23
220.01
4.0
2.7
10.2
10.7
g/l
1.46
439
872
582
1522
5.37
216.73
2.8
1.4
—
—
—
0
0
200
171
13.17
200.27
1.5
1.5
0.7
0.8
g/l
0.49
145
133
1260
6568
4.90
178.87
10.4
5.5
0.7
0.6
e9/l
16.39
1178
5575
375
778
5.95
178.55
2.1
1.8
1.1
1.5
g/l
3.22
352
700
1261
6592
4.89
177.91
10.4
5.5
0.0
0.0
e9/l
8.62
1179
5614
1284
6811
5.01
177.41
11.0
5.8
0.2
0.2
e9/l
9.80
1206
5881
1265
6722
4.79
172.02
10.5
5.6
1.9
1.9
e9/l
0.10
1193
5823
1167
6049
4.18
159.17
10.9
5.8
0.7
0.7
%
0.19
1143
5591
1183
6230
4.19
156.64
11.4
6.1
8.8
8.9
%
0.41
1157
5776
99
30
35.05
155.99
5.3
1.7
—
—
—
0
0
1179
6210
4.16
155.68
11.1
5.8
3.0
2.8
%
2.43
1155
5730
1179
6239
4.13
153.90
10.8
5.7
60.0
57.8
%
8.24
1153
5773
1187
6365
4.09
150.58
11.2
6.0
24.8
27.1
%
11.77
1160
5861
965
4617
3.63
143.58
10.0
5.6
—
—
—
0
0
373
939
4.84
139.94
2.4
1.4
—
—
—
0
0
1315
7826
4.37
137.04
12.7
9.0
4.9
4.1
e9/l
22.21
1237
6782
86
27
33.55
133.90
1.6
1.3
—
—
—
0
0
836
4031
3.18
115.47
6.8
4.1
—
—
—
0
0
120
8
161.62
114.87
1.5
1.0
—
—
—
0
0
119
108
11.80
113.72
1.6
2.1
1.3
1.0
e9/l
2.96
64
60
532
1990
3.47
111.99
2.6
2.0
—
—
—
0
0
102
76
14.24
109.96
1.6
2.2
628.7
552.4
e6/l
0.25
79
63
99
75
13.98
105.67
1.6
2.2
0.3
0.2
e9/l
1.90
77
63
427
1507
3.47
96.99
2.7
1.7
—
—
—
0
0
551
2375
2.98
88.07
2.0
1.4
2.6
2.6
g/l
0.02
402
1354
91
84
11.41
85.74
1.6
2.0
72.6
71.8
%
0.11
83
77
90
83
11.41
84.85
1.6
2.0
14.3
13.1
%
0.28
58
34
156
287
5.90
82.11
1.4
1.1
—
—
—
0
0
66
40
17.15
79.19
1.4
2.3
30.1
26.4
%
0.71
58
34
66
42
16.33
77.25
1.4
2.3
11.2
11.9
%
0.08
56
36
1384
10265
3.17
67.80
8.0
4.1
17.9
13.6
mm/h
16.76
1336
9368
390
1614
2.86
64.69
7.6
7.0
10.6
12.4
kpa
11.30
365
1538
390
1615
2.85
64.61
7.6
7.0
5.3
5.0
kpa
3.01
368
1536
101
156
6.83
63.03
1.1
1.1
1.4
1.6
g/l
1.84
95
142
931
5867
2.35
61.71
15.0
9.7
0.0
0.0
e9/l
1.77
807
4765
382
1616
2.78
60.35
7.7
7.0
2.1
1.0
mmol/l
5.50
309
1243
629
3405
2.37
58.72
9.1
6.7
—
—
—
0
0
49
30
16.80
58.34
1.3
2.0
159.6
196.7
e6/l
—
23
9
262
920
3.20
57.74
4.9
5.0
—
—
—
0
0
72
89
8.41
54.54
1.7
1.9
45.6
41.5
%
—
8
14
1075
7447
2.28
53.58
8.4
6.5
1.2
1.2
mmol/l
0.42
921
6217
1071
7412
2.27
53.45
7.7
6.2
10.2
11.9
umol/l
6.88
1036
7002
535
2828
2.32
51.49
2.1
1.6
1.1
1.3
mg/l
0.71
417
2193
267
1009
2.96
51.45
5.2
3.9
0.6
0.5
%
0.02
60
241
215
718
3.29
51.21
8.3
9.0
25.4
24.2
mmol/l
5.66
199
668
509
2644
2.34
50.94
6.9
4.6
—
—
—
0
0
64
75
8.84
50.56
1.8
2.1
892.5
669.8
e6/l
0.93
33
35
282
1115
2.84
49.92
5.5
4.0
0.6
0.9
%
1.03
79
340
258
984
2.92
48.75
5.6
4.1
0.0
0.1
%
1.50
64
259
269
1059
2.84
47.89
5.5
4.1
0.1
0.1
%
0.44
75
309
742
4598
2.12
46.99
3.9
3.0
1451.6
1580.1
ng/l
0.35
648
3967
985
6791
2.12
46.86
8.1
5.8
1.2
1.2
mmol/l
0.78
910
6067
329
1451
2.58
46.74
7.9
7.4
94.4
95.5
%
2.29
315
1393
81
138
6.12
45.84
2.0
1.6
—
—
—
0
0
81
138
6.12
45.84
2.0
1.6
—
—
—
0
0
81
138
6.12
45.84
2.0
1.6
—
—
—
0
0
81
138
6.12
45.84
2.0
1.6
—
—
—
0
0
1372
10898
2.55
44.69
11.4
7.5
78.8
79.8
u/l
0.32
1331
10143
54
60
9.27
44.41
3.3
2.3
605.4
1757.6
u/ml
1.81
54
60
328
1487
2.51
43.73
1.5
1.6
—
—
—
0
0
346
1643
2.40
41.48
1.3
1.3
443.1
583.8
titre
0.68
64
387
697
4413
2.00
39.75
4.8
3.9
7.4
7.4
ph
0.34
133
831
292
1340
2.43
37.46
3.6
2.9
221.6
210.0
ng/l
0.13
265
1218
416
2261
2.12
35.32
2.6
2.4
10.4
12.5
umol/l
8.40
391
2075
259
1163
2.46
34.68
8.2
7.6
—
—
—
0
0
899
6404
1.89
34.35
5.3
4.6
33.6
35.0
g/l
10.62
839
5939
261
1184
2.43
34.14
2.6
2.1
292.2
385.6
nmol/l
11.51
246
1068
387
2070
2.14
34.11
2.5
2.4
2.3
2.3
g/l
0.02
364
1902
55
86
6.58
33.82
1.1
1.0
1.5
1.3
u/ml
0.04
22
16
598
3762
1.93
33.29
2.8
2.2
3.1
3.0
mg/l
0.43
536
3159
483
2834
2.00
32.93
5.9
3.8
190.0
318.0
ng/l
1.41
398
2349
117
350
3.52
32.85
2.4
1.9
10.7
12.5
mg/l
1.82
109
317
132
428
3.27
32.63
4.0
3.7
—
—
—
0
0
415
2316
2.06
32.48
4.8
3.2
0.8
0.8
mmol/l
0.20
381
2148
266
1246
2.35
32.26
7.5
6.3
1.3
1.4
mmol/l
0.80
249
1196
57
98
5.99
31.93
1.1
1.1
2.1
5.1
u/ml
0.72
39
42
603
3867
1.88
31.18
4.3
3.1
—
—
—
0
0
852
6104
1.82
30.60
10.6
9.9
1.3
1.3
inr
0.20
224
1651
60
114
5.42
30.26
1.1
1.1
0.4
0.6
u/ml
0.25
35
40
184
750
2.64
29.99
10.6
10.1
—
—
—
0
0
359
1951
2.07
29.91
2.7
2.5
18.3
22.4
%
7.95
316
1657
1185
9432
1.91
29.89
6.6
4.9
85.0
2140.6
e6/l
2.40
14
147
275
1353
2.24
29.53
3.9
3.4
6.1
5.8
kpa
3.82
262
1315
614
4014
1.84
29.49
4.4
3.2
0.4
0.5
e6/l
0.71
481
3067
790
5576
1.80
29.42
3.5
2.7
146.4
141.5
ug/l
0.06
737
5033
46
71
6.64
28.63
1.2
1.0
4.5
1.0
u/ml
0.51
27
22
1074
8342
1.83
28.62
6.8
4.6
6.5
6.8
mmol/l
6.44
1024
7824
558
3569
1.85
28.55
5.5
3.9
88.5
87.5
%
0.39
543
3480
271
1345
2.21
28.42
4.0
3.4
2.8
1.8
mmol/l
3.51
230
1070
270
1354
2.19
27.54
8.6
7.6
121.2
119.4
g/l
0.74
259
1299
53
98
5.55
27.52
1.1
1.1
0.6
2.1
u/ml
0.60
32
39
198
881
2.42
26.72
6.3
3.6
7.4
7.4
ph
2.19
20
105
643
4364
1.78
26.58
4.5
3.3
76.8
78.8
e6/l
0.02
505
3377
199
891
2.40
26.48
6.4
3.6
5.2
5.1
kpa
0.18
189
824
375
2152
1.96
26.46
1.3
1.2
43.4
36.7
iu/ml
0.25
126
684
162
659
2.62
26.43
3.7
3.8
25.0
23.9
mmol/l
3.51
148
605
43
68
6.47
26.15
1.1
1.0
1.6
2.5
u/ml
0.21
25
20
60
130
4.75
26.05
1.3
1.2
—
—
—
0
0
778
5599
1.74
25.99
5.3
3.8
37.4
47.4
ng/l
0.72
592
4157
79
212
3.86
25.99
1.8
1.4
—
—
—
0
0
1182
9623
1.81
25.02
6.1
4.6
—
—
—
0
0
485
3092
1.81
24.34
3.4
2.6
5.6
5.9
e6/l
0.16
433
2710
48
92
5.34
23.98
1.3
1.2
—
—
—
0
0
464
2931
1.81
23.95
3.5
2.8
507.3
542.2
mosm/kgh2o
3.76
403
2489
708
5055
1.70
23.64
5.3
3.7
53.4
113.1
e6/l
2.44
532
3623
154
649
2.51
23.29
7.0
3.7
—
—
—
0
0
39
64
6.22
22.88
1.1
1.0
0.1
0.9
u/ml
0.70
22
16
366
2187
1.87
22.42
2.6
2.0
30.1
29.9
s
0.23
355
2107
792
5898
1.66
22.01
2.9
2.3
83.1
79.8
nmol/l
2.54
736
5149
41
76
5.51
21.24
1.8
2.7
42.1
37.6
%
0.57
23
26
1497
13432
2.25
20.44
36.5
15.0
25.3
25.2
mg/l
0.03
1412
10699
24
5
48.65
20.18
1.1
1.0
—
—
—
0
0
83
273
3.15
20.00
4.1
3.5
58.1
58.6
%
0.10
83
273
309
1810
1.87
19.92
8.6
6.3
103.1
104.2
mmol/l
3.65
304
1764
342
2070
1.82
19.84
1.3
1.2
19.6
15.1
u/ml
0.35
122
745
80
260
3.18
19.66
3.2
3.2
4.9
4.3
e9/l
1.24
80
260
371
2320
1.77
19.23
3.8
2.9
2.4
2.7
e6/l
0.30
200
1277
388
2468
1.75
18.91
3.7
2.8
0.9
1.3
e6/l
2.12
218
1418
299
1775
1.84
18.35
2.6
2.6
1.8
1.8
%
0.01
255
1562
212
1125
2.02
18.22
3.6
2.8
4.6
4.5
kpa
0.31
199
1091
656
4823
1.60
18.08
3.9
3.3
—
—
—
0
0
237
1318
1.93
17.78
2.6
2.8
65.3
66.2
g/l
1.03
212
1179
30
49
6.22
17.68
1.4
1.4
—
—
—
0
0
180
910
2.10
17.63
8.2
6.8
25.6
24.3
mmol/l
3.67
165
838
516
3597
1.63
17.61
3.5
2.8
7982.9
7910.2
umol/l
0.01
439
3054
315
1926
1.79
17.46
1.3
1.2
—
—
—
0
0
176
889
2.10
17.27
9.9
8.5
92.3
93.9
%
1.71
176
884
246
1400
1.89
17.17
2.7
2.1
0.2
0.2
g/l
0.04
233
1304
603
4412
1.58
16.60
2.7
2.5
56.7
58.1
u/l
0.12
566
4018
175
900
2.06
16.34
9.9
8.2
1.3
1.3
%
0.07
175
892
805
6338
1.53
15.63
2.3
2.1
93.6
94.8
pmol/l
0.29
435
3148
171
890
2.03
15.44
10.1
8.4
0.6
0.7
%
1.29
171
884
22
30
7.42
15.27
1.9
1.8
—
—
—
0
0
81
307
2.72
15.17
5.3
2.8
7.8
8.0
kpa
0.47
75
279
106
462
2.38
14.86
1.1
1.2
0.4
0.5
u/ml
0.17
13
28
513
3702
1.56
14.59
1.7
1.6
19.9
20.7
nmol/l
0.63
465
3083
1236
10778
1.59
14.32
36.6
18.8
14.2
13.8
%
15.07
1227
10519
218
1262
1.84
14.30
8.4
6.6
9.9
10.5
mmol/l
0.62
208
1200
227
1333
1.82
14.21
2.7
2.6
70.5
68.5
e9/l
0.38
152
1012
86
348
2.55
14.15
3.1
2.9
25.1
25.0
mmol/l
0.09
76
299
64
222
2.96
14.12
1.5
1.5
33.5
31.9
g/l
0.45
56
200
61
208
3.01
13.87
1.4
1.4
2458.6
1640.6
e6/l
0.61
40
151
78
306
2.63
13.67
2.0
2.1
123.3
128.3
g/l
0.75
35
227
68
249
2.81
13.61
2.8
2.6
—
—
—
0
0
57
191
3.06
13.37
1.4
1.3
69474.2
90106.8
e6/l
0.15
26
114
665
5151
1.49
13.24
3.1
3.4
2.3
2.4
mmol/l
1.63
580
4424
28
57
4.98
13.12
1.4
1.3
—
—
—
0
0
668
5186
1.48
13.12
4.3
3.7
—
6.0
—
0
5
97
432
2.32
12.97
7.5
7.0
1.2
1.3
mmol/l
0.44
85
379
24
43
5.65
12.91
2.2
1.7
—
—
—
0
0
118
572
2.14
12.85
8.7
4.0
25.2
24.8
mmol/l
0.62
109
526
590
4484
1.49
12.80
2.6
2.1
178.6
212.8
u/l
0.30
549
4184
51
167
3.12
12.45
1.4
1.4
—
—
—
0
0
295
1938
1.64
12.20
6.8
5.0
1.1
1.0
mmol/l
1.03
271
1768
817
6657
1.45
12.20
4.8
4.0
0.0
0.0
estimate
0.00
180
1230
48
154
3.18
12.13
1.1
1.0
—
13.9
—
0
8
383
2681
1.56
12.11
1.4
1.2
0.9
1.5
u/ml
1.62
92
673
214
1300
1.74
11.85
2.4
2.2
28.1
38.4
u/l
3.83
182
1117
816
6691
1.43
11.52
6.4
5.4
0.0
0.0
estimate
0.00
183
1230
823
6768
1.43
11.39
4.8
4.0
0.0
0.0
estimate
1.08
179
1204
187
1109
1.77
11.24
2.5
2.6
—
—
—
0
0
49
170
2.94
10.86
1.5
1.4
—
—
—
0
0
224
1414
1.68
10.75
2.0
2.1
355.4
130.5
ug/g
1.30
171
1096
118
612
2.00
10.74
2.6
1.9
1.3
2.5
ug/l
0.85
108
531
72
307
2.41
10.65
5.3
4.0
—
—
—
0
0
695
5594
1.42
10.57
2.4
2.2
—
—
—
0
0
81
365
2.28
10.57
1.4
1.6
—
—
—
0
0
105
526
2.06
10.52
2.5
3.7
43.3
64.3
mg/l
0.65
82
438
69
291
2.43
10.46
2.7
3.1
—
—
—
0
0
1118
9796
1.44
10.43
5.5
4.1
—
—
—
0
0
27
65
4.21
10.37
1.1
1.0
12.2
12.8
iu/ml
—
5
18
104
526
2.04
10.16
2.6
3.7
99.1
62.2
mg/l
0.37
80
436
83
390
2.19
9.81
2.5
3.8
—
—
—
0
0
101
514
2.03
9.71
2.6
3.7
5.5
1.7
ratio
0.59
12
42
36
112
3.26
9.61
1.3
1.3
15.0
12.5
u/l
0.45
30
105
428
3199
1.46
9.57
4.8
3.9
—
—
—
0
0
113
605
1.93
9.40
6.2
5.5
1.7
1.6
%
1.40
105
566
396
2950
1.45
8.92
2.9
3.1
2.5
2.5
mmol/l
2.80
333
2616
44
161
2.78
8.91
3.9
3.3
—
—
—
0
0
32
98
3.31
8.78
1.2
1.3
—
—
—
0
0
121
678
1.85
8.77
3.2
2.4
1.2
1.1
%
0.52
121
673
69
317
2.23
8.65
8.4
8.0
103.8
105.5
mmol/l
1.43
61
282
69
317
2.23
8.65
8.4
8.0
11.1
11.1
mmol/l
0.03
61
282
206
1349
1.60
8.48
3.3
2.4
6.3
7.0
ug/l
0.29
168
1170
109
599
1.88
8.40
6.4
5.6
0.9
0.9
%
0.19
101
562
231
1562
1.56
8.29
2.5
2.6
8.0
9.3
umol/l
0.40
200
1355
95
504
1.94
8.15
2.5
2.5
36.4
37.1
g/l
0.59
86
425
64
294
2.22
8.04
1.5
1.3
57.6
62.0
mmol/l
0.37
50
238
56
243
2.35
8.03
4.6
3.9
1.3
1.5
%
0.14
47
193
29
89
3.30
7.95
3.5
3.3
—
—
—
0
0
1157
10401
1.38
7.88
4.6
4.0
15.1
15.0
pmol/l
0.45
1058
9270
67
317
2.16
7.84
6.4
4.8
2.5
2.8
mmol/l
0.48
51
214
44
177
2.53
7.45
1.6
1.5
—
—
—
0
0
74
376
2.01
7.20
6.1
4.5
7.4
7.4
ph
2.34
65
311
17
38
4.51
7.18
2.4
1.4
—
—
—
0
0
145
907
1.66
7.18
3.8
3.2
4.9
4.0
e9/l
2.37
120
666
187
1245
1.57
7.16
4.0
3.5
86.8
92.6
ng/l
0.46
164
1056
87
474
1.88
6.93
2.8
1.9
23.0
21.6
s
0.47
78
429
395
3067
1.38
6.80
2.0
1.8
1192.8
1171.1
nmol/l
0.15
298
2259
218
1519
1.50
6.77
1.4
1.3
—
—
—
0
0
21
58
3.65
6.76
1.0
1.1
—
—
—
0
0
1494
14175
1.58
6.72
35.3
18.0
139.1
139.7
mmol/l
12.03
1476
13795
1464
13838
1.52
6.60
26.7
14.7
—
—
—
0
0
93
530
1.80
6.44
3.8
2.1
437.8
872.6
ug/l
0.55
87
499
120
736
1.68
6.42
1.5
1.7
1.8
1.5
g/l
1.87
99
633
1494
14207
1.55
6.28
35.6
18.2
4.0
4.0
mmol/l
2.09
1475
13809
148
965
1.59
6.21
1.2
1.2
—
—
—
0
0
18
51
3.56
5.61
32.0
24.2
137.5
128.2
ug/l
0.13
11
39
29
112
2.62
5.40
2.4
2.9
11.6
11.0
%
0.25
29
112
21
70
3.03
5.11
1.3
2.8
—
—
—
0
0
272
2078
1.37
5.07
27.7
28.1
1.5
1.4
inr
0.14
27
279
56
296
1.92
4.97
3.1
2.4
15.7
15.9
%
0.18
27
141
106
686
1.58
4.64
1.4
1.2
—
—
—
0
0
73
431
1.73
4.56
1.3
1.4
300.5
278.6
ug/g
0.44
42
238
118
786
1.54
4.56
3.4
3.2
4.2
4.4
pmol/l
1.83
103
682
59
328
1.83
4.51
1.1
1.2
1.9
4.0
u/ml
—
6
37
1492
14324
1.44
4.49
34.5
18.2
78.0
78.9
umol/l
0.37
1492
14319
437
3627
1.28
4.48
5.7
4.4
0.0
0.0
estimate
0.69
180
1182
91
573
1.62
4.47
5.4
4.2
—
—
—
0
0
423
3498
1.28
4.47
4.3
3.7
—
—
—
0
0
30
132
2.30
4.30
1.3
1.1
—
—
—
0
0
65
378
1.75
4.30
3.8
3.2
0.8
0.8
nmol/l
0.06
51
289
35
166
2.13
4.21
4.9
4.7
—
—
—
0
0
1320
12468
1.29
4.20
5.7
4.9
1.9
2.1
mu/l
1.46
1224
11185
172
1260
1.41
4.12
3.8
3.6
1.2
1.2
mmol/l
1.15
159
1070
1489
14327
1.41
4.06
16.8
10.9
24.0
24.6
u/l
0.79
1463
13734
35
169
2.09
4.03
1.2
1.2
—
—
—
0
0
32
150
2.16
3.97
3.9
3.8
60.8
56.5
%
0.71
23
97
29
132
2.22
3.87
1.3
1.1
—
—
—
0
0
93
612
1.55
3.83
1.3
1.2
—
—
—
0
0
1253
11826
1.25
3.60
35.1
16.7
38.9
38.7
%
0.31
825
7645
31
150
2.09
3.58
1.2
1.2
—
—
—
0
0
31
150
2.09
3.58
1.5
1.2
268.1
275.3
mosm/kgh2o
0.82
17
110
416
3517
1.24
3.55
3.0
2.3
—
—
—
0
0
382
3202
1.25
3.52
1.7
1.7
19749706.1
19984881.8
pmol/l
0.00
319
2572
9
17
5.32
3.51
1.4
1.2
—
—
—
0
0
9
17
5.32
3.51
1.4
1.2
—
—
—
0
0
9
17
5.32
3.51
1.4
1.2
—
—
—
0
0
6
6
10.03
3.50
1.3
1.0
—
—
—
0
0
20
81
2.49
3.47
1.3
1.3
—
—
—
0
0
71
450
1.60
3.46
1.5
1.6
—
—
—
0
0
63
388
1.65
3.44
1.1
1.1
—
—
—
0
0
22
95
2.33
3.34
5.5
2.2
—
—
—
0
0
524
4569
1.22
3.30
3.0
2.4
—
—
—
0
0
10
28
3.59
3.20
4.3
4.0
—
—
—
0
0
155
1167
1.36
3.19
1.6
1.5
—
—
—
0
0
12
39
3.09
3.09
4.3
6.6
26.8
24.9
mmol/l
0.95
12
34
29
147
1.99
3.00
1.3
1.5
—
—
—
0
0
7
13
5.40
2.87
1.3
1.1
—
—
—
0
0
31
165
1.90
2.81
1.2
1.2
2.9
6.0
u/ml
0.96
13
78
113
827
1.39
2.79
2.6
2.4
—
—
—
0
0
723
6575
1.18
2.73
4.5
4.0
—
—
—
0
0
6
10
6.02
2.70
1.2
1.0
—
—
—
0
0
21
99
2.14
2.65
1.2
1.7
—
—
—
0
0
10
32
3.14
2.65
1.0
1.1
—
—
—
0
0
10
32
3.14
2.65
1.0
1.1
—
—
—
0
0
10
32
3.14
2.65
1.0
1.1
—
—
—
0
0
29
155
1.89
2.62
1.3
1.3
177.6
258.3
pmol/l
2.38
22
117
29
155
1.89
2.62
1.5
1.2
—
—
—
0
0
356
4118
0.83
2.58
2.9
3.1
—
—
—
0
0
9
25
3.61
2.57
1.6
1.4
—
—
—
0
0
52
331
1.59
2.56
1.5
1.6
7080.1
13743.2
e6/l
1.30
37
244
6
11
5.47
2.54
1.0
1.0
—
—
—
0
0
33
186
1.79
2.54
1.3
1.3
—
—
—
0
0
14
56
2.51
2.53
1.2
1.2
—
0.4
—
0
5
103
756
1.39
2.52
1.5
1.3
—
—
—
0
0
19
88
2.17
2.51
3.7
2.6
—
—
—
0
0
30
165
1.83
2.50
1.1
1.3
—
—
—
0
0
9
26
3.47
2.48
4.7
6.9
—
—
—
0
0
44
273
1.63
2.42
1.4
1.5
—
—
—
0
0
6
12
5.01
2.40
1.2
1.0
—
—
—
0
0
92
670
1.40
2.38
1.5
1.3
—
—
—
0
0
27
147
1.85
2.33
1.5
1.2
—
—
nmol/l
—
0
0
10
35
2.87
2.30
1.2
1.4
—
—
—
0
0
35
210
1.68
2.21
2.0
1.3
107.5
131.3
u/ml
—
10
39
6
14
4.30
2.15
1.0
1.2
—
—
—
0
0
9
30
3.01
2.15
1.1
1.3
—
—
—
0
0
18
89
2.03
2.06
1.6
1.7
—
—
—
0
0
18
89
2.03
2.06
1.2
1.2
—
—
—
0
0
15
69
2.18
2.04
1.3
1.2
155.1
137.7
nmol/l
0.69
15
69
9
32
2.82
2.00
1.1
1.3
—
—
—
0
0
96
727
1.34
1.99
2.3
2.1
14.0
12.3
nmol/l
1.07
79
633
29
171
1.71
1.97
1.5
1.2
—
0.5
—
0
11
101
774
1.32
1.94
1.2
1.2
67.9
144.8
iu/ml
2.39
38
287
160
1303
1.25
1.92
1.6
1.5
—
—
—
0
0
43
283
1.53
1.91
1.4
1.2
—
—
—
0
0
32
196
1.65
1.90
1.5
1.2
237.2
282.9
u/ml
0.42
19
111
23
128
1.81
1.90
1.1
1.3
—
30.4
—
0
9
27
159
1.71
1.86
1.4
1.5
52.4
62.6
%
0.62
21
105
48
326
1.49
1.85
1.1
1.1
—
—
—
0
0
194
1621
1.22
1.85
4.5
4.5
—
—
—
0
0
1507
14757
1.25
1.76
45.4
22.7
269.9
246.8
e9/l
26.11
1491
14335
15
74
2.04
1.75
1.9
2.9
7.4
7.4
ph
—
6
24
32
201
1.60
1.75
1.1
1.3
—
—
—
0
0
25
147
1.71
1.74
1.1
1.2
—
—
—
0
0
1507
14760
1.25
1.73
45.2
22.6
91.6
91.5
fl
0.14
1498
14502
1507
14761
1.24
1.73
45.2
22.6
30.1
30.4
pg
7.04
1498
14501
485
4402
1.14
1.72
3.2
3.2
897.6
352.9
mg/l
1.00
293
2693
1507
14762
1.24
1.72
45.4
22.7
4.4
4.4
e12/l
1.05
1492
14285
5
13
3.85
1.71
1.4
1.8
—
—
—
0
0
5
13
3.85
1.71
1.4
1.0
—
—
—
0
0
55
391
1.42
1.70
1.3
1.2
—
—
—
0
0
1507
14765
1.24
1.69
45.7
22.8
130.6
133.0
g/l
8.78
1498
14506
1507
14765
1.24
1.69
45.5
22.7
7.8
6.7
e9/l
34.25
1492
14290
22
126
1.76
1.68
1.2
1.6
—
—
—
0
0
12
55
2.19
1.67
1.3
1.2
1.0
1.1
ratio
—
6
16
36
236
1.54
1.66
1.9
1.3
—
—
—
0
0
415
3737
1.15
1.64
1.6
1.6
1.3
1.3
mmol/l
0.07
347
3091
11
49
2.25
1.63
1.8
1.2
18.2
14.6
g/l
—
6
36
495
4516
1.14
1.61
3.2
3.1
6.5
7.0
mmol/l
2.10
418
3724
6
20
3.01
1.58
6.0
8.1
—
—
—
0
0
39
265
1.48
1.54
1.7
2.8
—
—
—
0
0
8
33
2.43
1.54
1.3
1.1
—
—
—
0
0
60
803
0.74
1.53
4.8
3.7
—
—
—
0
0
197
1683
1.19
1.52
3.0
4.0
4.0
20.2
ug/l
2.51
174
1379
29
185
1.58
1.52
1.1
1.2
—
—
—
0
0
212
1824
1.19
1.51
1.3
1.3
—
—
—
0
0
6
21
2.86
1.50
1.2
1.1
—
—
—
0
0
44
310
1.43
1.46
2.4
2.9
31.6
34.5
umol/l
0.37
34
259
69
525
1.33
1.45
2.7
2.9
0.3
0.3
g/l
0.02
22
190
14
75
1.87
1.34
1.9
1.9
17.0
17.8
nmol/l
0.10
14
67
11
54
2.04
1.33
1.5
2.4
—
—
—
0
0
140
1177
1.21
1.31
5.5
4.2
—
—
—
0
0
8
34
2.36
1.29
1.1
1.0
—
—
—
0
0
25
377
0.66
1.28
1.3
1.3
—
—
—
0
0
20
122
1.65
1.27
1.1
1.1
—
—
—
0
0
327
2958
1.13
1.21
5.7
4.5
1.0
1.0
kg/l
0.40
60
464
6
26
2.31
1.18
2.5
1.2
—
—
—
0
0
6
26
2.31
1.18
1.2
1.1
—
—
—
0
0
8
38
2.11
1.18
2.5
1.8
—
—
—
0
0
313
3439
0.89
1.11
1.3
1.3
—
—
—
0
0
54
693
0.77
1.09
1.3
1.4
—
—
—
0
0
5
21
2.38
1.09
1.0
1.1
—
—
—
0
0
18
112
1.61
1.09
2.2
2.2
—
—
—
0
0
14
82
1.71
1.05
2.1
1.5
—
—
—
0
0
31
428
0.72
1.03
4.7
4.7
—
—
—
0
0
9
46
1.96
1.03
4.1
2.2
—
—
—
0
0
25
171
1.47
1.02
2.0
2.2
—
—
—
0
0
1302
12723
1.11
0.99
6.3
6.2
40.8
40.3
mmol/mol
1.13
1212
11557
10
54
1.86
0.96
3.0
2.1
—
—
—
0
0
155
1357
1.16
0.95
1.3
1.4
—
—
—
0
0
10
173
0.58
0.95
1.0
1.8
—
—
—
0
0
33
245
1.35
0.89
1.3
1.5
—
—
—
0
0
17
112
1.52
0.85
1.5
1.2
—
—
—
0
0
15
97
1.55
0.81
1.3
1.2
—
—
—
0
0
43
340
1.27
0.78
2.5
3.3
454.8
1163.4
u/ml
0.42
36
312
34
438
0.77
0.76
2.1
1.8
—
—
—
0
0
6
34
1.77
0.76
1.0
1.1
—
—
—
0
0
42
526
0.79
0.76
1.5
1.4
—
—
—
0
0
135
1195
1.14
0.75
5.1
3.6
—
—
—
0
0
5
25
2.00
0.72
1.4
1.2
—
—
—
0
0
473
4477
1.08
0.72
5.5
4.1
—
—
—
0
0
13
84
1.55
0.72
1.7
2.6
—
—
—
0
0
7
40
1.75
0.71
1.9
1.7
—
—
—
0
0
14
93
1.51
0.69
1.1
1.1
—
—
—
0
0
14
204
0.68
0.68
1.8
2.2
8.6
1301.1
u/ml
0.51
14
197
18
127
1.42
0.68
2.2
1.7
—
—
—
0
0
15
102
1.47
0.67
2.5
2.5
—
—
—
0
0
5
28
1.79
0.66
2.0
1.5
—
—
—
0
0
39
315
1.24
0.62
1.4
1.4
40.8
34.3
iu/l
0.43
34
272
8
49
1.64
0.62
2.0
1.9
—
—
—
0
0
8
49
1.64
0.62
3.4
1.6
—
—
—
0
0
488
4650
1.07
0.62
3.9
3.9
8.3
8.3
mg/mmol
0.00
285
2811
5
30
1.67
0.61
2.0
1.4
—
—
—
0
0
16
113
1.42
0.61
1.9
1.9
—
—
—
0
0
10
64
1.57
0.58
1.2
1.2
—
—
—
0
0
10
64
1.57
0.58
1.0
1.0
—
—
—
0
0
25
193
1.30
0.57
1.6
1.1
—
—
—
0
0
18
132
1.37
0.57
1.6
1.4
17035.1
91220.2
e6/l
—
9
89
26
203
1.29
0.55
1.3
1.3
15.6
11.1
u/l
0.46
18
156
28
222
1.27
0.54
1.4
1.5
—
—
—
0
0
25
316
0.79
0.53
1.7
1.5
92.2
210.5
pmol/l
1.95
25
309
6
39
1.54
0.53
1.0
1.0
—
—
—
0
0
32
259
1.24
0.52
1.2
1.4
—
—
—
0
0
36
297
1.22
0.50
1.3
1.4
8.1
37.7
e6/l
0.82
28
234
36
297
1.22
0.50
1.4
1.4
1650.3
597.9
e6/l
0.35
29
248
20
153
1.31
0.50
1.4
1.2
—
—
—
0
0
10
68
1.47
0.47
1.0
1.0
—
—
—
0
0
20
155
1.29
0.47
1.5
1.6
—
—
—
0
0
7
48
1.46
0.46
1.4
1.4
—
—
—
0
0
43
366
1.18
0.45
1.1
1.1
—
—
—
0
0
99
896
1.11
0.44
1.4
1.2
—
—
—
0
0
13
95
1.37
0.43
1.2
1.5
15.0
14.2
umol/l
0.13
13
89
6
93
0.64
0.42
20.3
2.6
13.7
13.2
%
—
6
93
5
32
1.56
0.42
3.0
1.3
—
—
—
0
0
14
182
0.77
0.39
1.3
1.2
—
—
—
0
0
18
142
1.27
0.38
1.9
1.4
—
—
—
0
0
10
72
1.39
0.37
2.2
1.5
—
—
—
0
0
27
226
1.20
0.36
1.5
1.4
—
—
—
0
0
5
76
0.66
0.35
1.0
1.4
—
—
—
0
0
5
76
0.66
0.35
1.0
1.4
—
—
—
0
0
5
78
0.64
0.35
1.0
1.5
—
—
—
0
0
36
310
1.16
0.35
1.8
1.9
5.6
4.9
iu/l
0.10
14
109
16
126
1.27
0.35
1.0
1.2
—
—
—
0
0
9
124
0.72
0.35
1.4
2.1
—
1.0
—
0
5
1344
13315
1.05
0.32
5.2
4.9
5.9
6.0
mmol/l
2.37
1240
11873
7
52
1.35
0.31
1.6
1.1
—
—
—
0
0
7
96
0.73
0.31
1.3
1.1
—
—
—
0
0
21
175
1.20
0.30
1.8
1.5
—
—
—
0
0
23
270
0.85
0.28
1.3
1.5
0.9
0.8
nmol/l
0.49
17
222
64
584
1.10
0.28
2.3
2.6
—
—
—
0
0
17
203
0.84
0.26
3.2
2.4
—
—
—
0
0
9
75
1.20
0.25
2.7
1.2
0.8
1.1
nmol/l
—
9
55
15
124
1.21
0.24
1.1
2.3
1.4
2.1
u/field
—
8
35
18
153
1.18
0.22
2.1
1.9
14135.4
2558.3
u/l
—
7
54
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
21
241
0.87
0.21
1.2
1.3
114.7
222.2
miu/ml
—
6
100
33
296
1.12
0.21
1.4
1.2
3.7
3.8
mmol/l
0.19
28
281
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
419
4094
1.03
0.21
5.2
5.4
2.3
4.6
ug/l
1.38
367
3619
0
13
0.00
0.21
0.0
1.0
—
10.8
—
0
5
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
1279
12697
1.03
0.20
4.2
4.1
1.2
1.3
mmol/l
2.43
1148
11298
21
184
1.14
0.19
1.5
1.5
—
—
—
0
0
10
81
1.24
0.18
2.1
1.2
—
—
—
0
0
10
82
1.22
0.17
2.6
1.7
—
—
—
0
0
21
187
1.12
0.16
1.8
1.5
—
—
—
0
0
6
77
0.78
0.15
1.8
1.8
—
—
—
0
0
17
192
0.88
0.14
1.0
1.1
—
—
—
0
0
30
275
1.09
0.14
1.2
1.2
—
—
—
0
0
31
335
0.92
0.13
5.2
3.6
29.5
26.4
mg/l
0.20
22
208
21
190
1.11
0.12
1.8
1.5
—
—
—
0
0
21
190
1.11
0.12
1.8
1.5
—
—
—
0
0
5
44
1.14
0.10
1.8
1.5
—
—
—
0
0
5
45
1.11
0.09
1.0
1.2
—
—
—
0
0
16
176
0.91
0.09
2.7
2.8
—
—
—
0
0
14
126
1.11
0.09
1.4
1.5
—
—
—
0
0
37
352
1.05
0.08
2.5
2.4
123.7
78.6
ug/min
0.30
25
203
8
77
1.04
0.07
8.5
15.1
—
—
—
0
0
33
347
0.95
0.07
3.0
2.2
—
—
—
0
0
126
1287
0.98
0.07
1.6
1.6
—
—
—
0
0
19
204
0.93
0.07
1.0
1.0
—
—
—
0
0
9
86
1.05
0.07
4.7
5.9
—
—
—
0
0
44
423
1.04
0.06
13.4
11.0
—
—
—
0
0
234
2366
0.99
0.05
3.1
3.3
0.6
0.8
ug/l
5.28
153
1661
12
112
1.07
0.03
1.1
1.2
2.1
1.5
nmol/l
0.77
12
100
10
107
0.93
0.02
1.0
1.0
958.2
679.2
ng/l
—
5
64
100
1009
0.99
0.01
3.9
3.3
—
—
—
0
0
1315
13141
1.00
0.01
4.7
4.6
1.5
1.5
mmol/l
1.85
1201
11801
10
106
0.94
0.01
1.0
1.0
296.4
334.1
ng/l
—
5
67
10
106
0.94
0.01
1.0
1.3
—
—
—
0
0
10
96
1.04
0.00
2.2
2.1
1.5
2.0
ug/l
—
10
81
58
584
0.99
0.00
2.2
3.1
105.2
6779.4
u/ml
0.80
49
500
58
578
1.00
0.00
1.8
1.5
—
—
—
0
0
1326
13262
1.00
0.00
4.8
4.7
4.5
4.6
mmol/l
3.17
1219
12010
1359
13591
1.00
0.00
5.3
5.2
2.6
2.7
mmol/l
5.54
1252
12224
63
627
1.00
0.00
2.2
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
2.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
211.2
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
19.5
—
0
5
0
7
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
14.6
—
0
6

Mortality – FinRegistry

Association

Association between endpoint ASTHMA_OPPORTUNIST_INFECTIONS and mortality.

Females

Parameter HR [95% CI] p-value
ASTHMA_OPPORTUNIST_INFECTIONS 1.696 [1.51, 1.91] < 0.001
Birth year 0.994 [0.98, 1.01] 0.305

During the follow-up period (1.1.1998 — 31.12.2019), 996 out of 3792 females with ASTHMA_OPPORTUNIST_INFECTIONS died.

Males

Parameter HR [95% CI] p-value
ASTHMA_OPPORTUNIST_INFECTIONS 1.784 [1.56, 2.04] < 0.001
Birth year 0.989 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 952 out of 2501 males with ASTHMA_OPPORTUNIST_INFECTIONS died.

Mortality risk

Mortality risk for people of age

years, who have ASTHMA_OPPORTUNIST_INFECTIONS.

N-year risk Females Males
1 0.117% 0.382%
5 0.809% 2.183%
10 2.403% 5.354%
15 5.126% 10.554%
20 8.776% 16.998%

Relationships between endpoints

Index endpoint: ASTHMA_OPPORTUNIST_INFECTIONS – Asthma and opportunity respiratory infection

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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