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Asthma

J10_ASTHMA

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493
Cause of death: ICD-10 J45, J46
Cause of death: ICD-9 493
Cause of death: ICD-8 493

2 out of 7 registries used, show all original rules.

48366

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Check minimum number of events None

48366

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Include endpoints None

48366

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Remove individuals based on genotype QC

46683

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J10_ASTHMA

Control definitions

Control exclude ASTHMA_EXCL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 46683 28570 18113
Unadjusted prevalence (%) 11.33 12.41 9.97
Mean age at first event (years) 45.03 43.42 47.58

Mortality

Not a core endpoint, no data to show.

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Not a core endpoint, no data to show.

Correlations

Index endpoint: J10_ASTHMA – Asthma
GWS hits:

Survival analyses between endpoints

Plot

before Asthma
after Asthma

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