Benign neoplasm of breast

CD2_BENIGN_BREAST

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D24&
  • Hospital discharge: ICD-9 217
  • Hospital discharge: ICD-8 21799
  • Cause of death: ICD-10 D24&
  • Cause of death: ICD-9 217
  • Cause of death: ICD-8 21799

2 out of 7 registries used, show all original rules.

4945

4. Check minimum number of events

None

4945

5. Include endpoints

None

4945

6. Filter based on genotype QC (FinnGen only)

4945

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasma benignum mammae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 36691 36691 -
Only index persons 33454 33454 -
Unadjusted period prevalence (%)
Whole population 1.05 1.05 -
Only index persons 1.23 1.23 -
Median age at first event (years)
Whole population - 43.94 -
Only index persons - 42.89 -

-FinnGen-

Key figures

All Female Male
Number of individuals 4945 4945 -
Unadjusted period prevalence (%) 1.69 1.69 -
Median age at first event (years) 42.55 42.55 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
4473
Matched controls
44730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D24
ICD-10 Finland
Benign neoplasm of breast
3842.7
323.0
2984
23
2170A
ICD-9 Finland
Benign neoplasm of breast[NEOPLASMA BENIGNUM MAMMAE]
+∞
323.0
621
*
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
36.0
323.0
1360
536
9702
FHL
Breast exploration and possible tumor removal
21.4
323.0
530
279
N63
ICD-10 Finland
Unspecified lump in breast
6.8
323.0
1095
2030
21799
ICD-8 Finland
Benign neoplasm of breast
+∞
323.0
927
*
HAB99
NOMESCO Finland
Other partial excision of mammary gland
8.2
207.9
495
672
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
3.6
150.2
761
2385
HAA10
NOMESCO Finland
Biopsy of mammary gland
13.8
116.5
206
156
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
6.0
115.9
338
598
N60.2
ICD-10 Finland
Fibroadenosis of breast
14.8
111.5
191
134
HAB40
NOMESCO Finland
Wedge excision of mammary gland
3.2
93.0
537
1814
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
4.5
87.3
327
763
D48.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Breast
5.7
85.0
259
481
HA1AA
NOMESCO Finland
X-ray mammography
2.6
83.7
683
2873
9703
FHL
Breast resection
9.0
82.2
180
208
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
3.7
69.0
328
947
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
55.5
1103
6742
N64.5
ICD-10 Finland
Other signs and symptoms in breast
4.2
54.4
219
545
N60.1
ICD-10 Finland
Diffuse cystic mastopathy
7.5
53.7
130
177
N64.9
ICD-10 Finland
Disorder of breast, unspecified
5.4
41.4
128
242
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
2.3
40.4
389
1751
X19
ICPC
Breast lump/mass female
3.9
38.0
163
430
XX2AT
NOMESCO Finland
Other injection with ultrasound examination
4.4
35.9
134
311
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
3.7
35.4
161
447
115
Kela drug reimbursment
Breast cancer
1.9
35.2
575
3225
HAB20
NOMESCO Finland
Excision of lactiferous duct
11.0
32.9
63
58
HA4GT
NOMESCO Finland
Labeling mammary gland pathology with galactographic guidance
16.4
32.4
52
32
HA1CG
NOMESCO Finland
Extensive MRI examination of mammary gland with high intensity magnet
3.7
32.3
148
414
C50.99
ICD-10 Finland
Breast, unspecified
2.7
31.8
222
836
ZXA05
NOMESCO Finland
Left side
1.6
30.8
1101
7739
N60.8
ICD-10 Finland
Other benign mammary dysplasias
9.5
28.6
59
63
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
2.9
27.8
171
595
HA3ST
NOMESCO Finland
Removal of lesion of breast with radiological guidance
9.3
26.4
55
60
ZXA00
NOMESCO Finland
Right side
1.5
26.1
1150
8421
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
1.9
25.3
386
2099
HAC20
NOMESCO Finland
Total mastectomy
2.1
25.2
292
1425
HA5CB
NOMESCO Finland
Galactography
11.3
24.6
46
41
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
24.3
1090
7990
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
2.8
23.9
163
606
HA6BA
NOMESCO Finland
Breast tomosynthesis specimen
3.6
23.0
104
290
PJA12
NOMESCO Finland
Sentinel node biopsy
1.7
22.8
471
2837
N60.0
ICD-10 Finland
Solitary cyst of breast
5.5
22.7
68
126
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
3.4
22.2
108
320
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
2.7
22.1
160
617
R92
ICD-10 Finland
Abnormal findings on diagnostic imaging of breast
6.4
21.4
56
88
L02BA01
ATC
tamoxifen; oral
2.0
20.5
262
1330
HAE99
NOMESCO Finland
Other reconstruction of breast
4.3
20.3
75
175
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
1.9
19.3
276
1466
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
3.1
19.1
109
361
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
3.2
18.8
99
313
N64.8
ICD-10 Finland
Other specified disorders of breast
6.0
17.9
49
82
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
2.0
17.9
240
1244
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
2.0
17.3
217
1097
9736
FHL
Subcutaneous tumor removal in operating room or anesthesia
3.8
17.2
73
195
C50
ICD-10 Finland
Malignant neoplasm of breast
2.3
16.6
153
673
HA1AE
SPAT
NA
2.8
16.3
106
387
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
16.1
1339
10817
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.3
15.9
1501
12354
A02BC05
ATC
esomeprazole; systemic
1.3
15.3
1679
14093
L02BG04
ATC
letrozole; oral
1.7
15.3
364
2278
Z85.3
ICD-10 Finland
Personal history of malignant neoplasm of breast
3.8
15.3
64
170
N64.4
ICD-10 Finland
Mastodynia
2.2
15.2
160
751
N61
ICD-10 Finland
Inflammatory disorders of breast
2.4
14.8
128
549
A03FA01
ATC
metoclopramide; systemic, rectal
1.4
14.8
914
7024
TQW20
NOMESCO Finland
Tatoe
3.1
14.2
79
262
WX702
NOMESCO Finland
Supraglottic ventilation device
1.9
14.1
224
1238
J01DB01
ATC
cefalexin; oral
1.3
14.1
3435
31934
X21
ICPC
Breast sympt/compl female other
2.4
14.1
123
531
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
2.6
14.0
101
393
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.7
13.9
291
1753
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
2.6
13.9
102
401
R4110
NOMESCO Finland
Physiotherapy
1.3
13.8
1020
8053
61000
ICD-8 Finland
Chronic cystic disease of breast, Fibroadenomatosis mammae
3.7
13.7
59
161
HA2AT
NOMESCO Finland
Cytology of mammary gland with ultrasound guidance
4.6
13.5
46
101
WX402
NOMESCO Finland
General anaesthesia
1.4
13.2
622
4541
6101A
ICD-9 Finland
Benign mammary dysplasias, Diffuse cystic mastopathy
4.6
13.0
44
96
Z00.0
ICD-10 Finland
General medical examination
1.4
12.9
694
5191
N02BE01
ATC
paracetamol; systemic, rectal
1.3
12.6
3720
35145
HA1TE
NOMESCO Finland
Supplementary or limited ultrasound examination of mammary glands
2.8
12.1
76
273
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
1.8
12.1
210
1196
61099
ICD-8 Finland
Chronic cystic disease of breast, Unspecified
4.7
12.1
40
86
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
12.0
1521
12901
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
2.3
12.0
106
462
N60.9
ICD-10 Finland
Benign mammary dysplasia, unspecified
4.3
11.9
43
101
Z01.6
ICD-10 Finland
Radiological examination, not elsewhere classified
1.5
11.9
366
2446
Z80.3
ICD-10 Finland
Family history of malignant neoplasm of breast
2.4
11.8
96
401
R51.80
ICD-10 Finland
Headache
1.4
11.8
607
4503
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
1.6
11.7
308
1978
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
11.7
971
7780
N60.4
ICD-10 Finland
Mammary duct ectasia
7.7
11.6
26
34
THA00
NOMESCO Finland
Needle biopsy of mamilla
8.1
11.5
25
31
HA3RT
NOMESCO Finland
Coagulation of mammary neoplasm under radiological guidance
15.0
11.3
18
12
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
2.9
11.1
67
237
WX110
NOMESCO Finland
Local anesthesy
1.2
11.0
2778
25423
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
10.9
1027
8362
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
1.4
10.9
529
3880
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.3
10.6
1396
11855
X18
ICPC
Breast pain female
2.5
10.6
83
342
8520/2-C50.9
ICD-O-3
Lobular carcinoma in situ, NOS, of breast, NOS
11.2
10.5
19
17
Z31.5
ICD-10 Finland
Genetic counselling
1.7
10.5
211
1259
J02AC01
ATC
fluconazole; systemic
1.2
10.5
1981
17518
N62
ICD-10 Finland
Hypertrophy of breast
1.7
10.5
197
1153
D05.0
ICD-10 Finland
Lobular carcinoma in situ
6.2
10.4
27
44
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.7
10.4
232
1430
A04AA02
ATC
granisetron; systemic, transdermal
1.6
10.1
233
1444
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.3
10.1
1069
8822
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
2.0
9.9
130
673
HAC25
NOMESCO Finland
Radical mastectomy
3.9
9.8
38
97
ZZR10
NOMESCO Finland
Flap of skin and muscle
3.3
9.6
46
140
C50.9
ICD-10 Finland
Malignant neoplasm: Breast, unspecified
3.3
9.5
45
136
J01FA10
ATC
azithromycin; systemic
1.2
9.2
2456
22380
Z03.8
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
9.0
159
917
J01DA01
ATC
[U] cefalexin; systemic
1.2
9.0
2549
23353
HA1RA
SPAT
NA
1.9
8.9
128
685
HAE00
NOMESCO Finland
Reconstruction of breast using prosthesis
3.8
8.8
35
92
17402
ICD-8 Finland
Malignant neoplasm of breast, Glandulae
4.1
8.7
32
78
R22.2
ICD-10 Finland
Localized swelling, mass and lump, trunk
1.9
8.7
120
634
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
2.3
8.6
73
315
H02AB02
ATC
dexamethasone; systemic
1.4
8.5
402
2931
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
1.6
8.5
224
1442
HAD50
NOMESCO Finland
Removal of prosthetic implant from breast
4.1
8.4
31
76
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
1.9
8.3
123
670
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
1.4
8.2
423
3132
A03FA02
ATC
cisapride; oral, rectal
1.5
8.2
299
2077
LC2DE
NOMESCO Finland
Demanding ultrsound examination of uterus, parametrium and lower part of abdomen with speciel methods
1.6
8.1
201
1276
9719
FHL
Other measure in this category
4.8
8.0
25
52
D01
ICPC
Abdominal pain/cramps general
1.4
8.0
410
3032
5702
FHL
Local lymph node removal (eg armpit, groin)
4.1
7.9
29
71
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
2.5
7.9
58
232
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
3.0
7.8
43
146
C50.92
ICD-10 Finland
Malignant tumor in another specified localization in lobular gland, lobular tumor
3.6
7.8
33
92
N60.3
ICD-10 Finland
Fibrosclerosis of breast
9.4
7.8
15
16
Z42.1
ICD-10 Finland
Follow-up care involving plastic surgery of breast
3.1
7.8
40
130
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
7.8
557
4348
ZZF00
NOMESCO Finland
Graft of adipose tissue
2.6
7.7
51
194
HAB10
NOMESCO Finland
Microductectomy of mammary gland
45.0
7.7
9
*
QBE20
NOMESCO Finland
Excision and repair of scar or web of skin of trunk
3.0
7.7
42
142
HA3AT
NOMESCO Finland
Pucture of mammary gland cyst with ultrasound examination
2.9
7.7
44
151
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
1.6
7.7
204
1317
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
7.6
633
5043
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
2.0
7.6
89
446
A02BC02
ATC
pantoprazole; systemic
1.2
7.5
2623
24297
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.3
7.5
457
3483
N03AX16
ATC
pregabalin; oral
1.2
7.5
885
7373
ZZQ10
NOMESCO Finland
Free microvascular graft of skin and muscle
3.7
7.4
30
81
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
7.4
908
7591
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
1.3
7.4
798
6574
J01MA02
ATC
ciprofloxacin; systemic
1.2
7.4
1326
11549
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
7.3
1688
15046
C50.31
ICD-10 Finland
Malignant tumor of the lower inner quadrant of the mammary gland, ductal tumor
2.3
7.3
62
270
ZSH00
NOMESCO Finland
Procedure related to previous procedure classified in chapter H
3.1
7.3
38
125
X79
ICPC
Benign neoplasm breast female
6.8
7.3
17
25
SPAT1336
SPAT
Request for examination
1.7
7.2
139
824
HA1CM
NOMESCO Finland
Mammary gland extensive MRI examination with 3 Tesla magnet
3.7
7.1
29
79
A02BC01
ATC
omeprazole; systemic
1.2
7.1
1024
8711
UJF32
NOMESCO Finland
Coloscopy
1.2
7.1
930
7831
C07AA05
ATC
propranolol; systemic
1.3
7.1
772
6365
L82
ICD-10 Finland
Seborrhoeic keratosis
1.3
7.1
566
4488
EB1SA
SPAT
NA
1.7
7.0
132
777
HWD00
NOMESCO Finland
Reoperation for deep haemorrhage in surgery of mammary gland
2.8
6.8
41
149
M01AE03
ATC
ketoprofen; systemic, rectal
1.2
6.8
1403
12362
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.2
6.7
2523
23399
L02
ICPC
Back symptom/complaint
1.4
6.7
337
2487
HAC10
NOMESCO Finland
Subcutaneous mastectomy with preservation of mamilla
5.2
6.6
19
37
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
1.6
6.5
175
1137
ZXA10
NOMESCO Finland
Bilateral
1.3
6.5
690
5664
C50.82
ICD-10 Finland
Overall malignant tumor of the mammary gland, lobular tumor
2.5
6.5
46
182
S18
ICPC
Laceration/cut
1.2
6.5
1484
13181
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.5
6.4
198
1327
6117B
ICD-9 Finland
Other disorders of breast, Signs and symptoms in breast[TUMOR MAMMAE]
2.9
6.4
35
120
R05
ICPC
Cough
1.2
6.4
854
7201
N05CF01
ATC
zopiclone; oral
1.2
6.4
1203
10501
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
1.5
6.3
191
1274
S04
ICPC
Lump/swelling localized
1.4
6.3
333
2475
6262A
ICD-9 Finland
Disorders of menstruation and other abnormal bleeding from female genital tract, Excessive or frequent menstruation[HYPERMENORRHOEA]
1.7
6.3
120
711
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.3
6.3
465
3647
R42
ICD-10 Finland
Dizziness and giddiness
1.2
6.3
801
6719
C50.00
ICD-10 Finland
Malignant tumor of nipple and areola, no histological veryfication
2.7
6.2
38
140
8113
FHL
Fractional scraping
1.4
6.2
326
2426
1744A
ICD-9 Finland
Malignant neoplasm of female breast, Upper-outer quadrant
2.6
6.2
41
157
HA1BG
NOMESCO Finland
MRI examination of mammary gland with high intensity magnet
2.6
6.2
41
157
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.3
6.1
378
2884
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.3
6.1
421
3267
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
1.9
6.1
81
429
R07.4
ICD-10 Finland
Chest pain, unspecified
1.2
6.1
928
7929
N02AX02
ATC
tramadol; systemic, rectal
1.2
6.0
1490
13304
C50.5
ICD-10 Finland
Malignant neoplasm: Lower-outer quadrant of breast
4.4
6.0
20
46
9733
FHL
Excision of skin change in operating room or anesthesia
2.3
6.0
53
237
P01AB01
ATC
metronidazole; oral, rectal
1.2
6.0
1673
15085
HAE05
NOMESCO Finland
Reconstruction of breast using soft tissue and prosthesis
3.0
6.0
31
103

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
640
1535
4.64
247.21
1.4
1.3
—
—
—
0
0
1004
5693
1.96
71.05
1.3
1.2
—
—
—
0
0
2524
18957
1.68
67.17
2.2
2.1
—
—
—
0
0
644
4031
1.69
30.52
1.4
1.4
—
—
—
0
0
1744
13780
1.41
27.28
2.2
2.2
—
—
—
0
0
2254
19540
1.28
15.93
5.1
5.2
1.2
1.2
mmol/l
3.08
2015
17568
216
1204
1.83
15.20
1.3
1.2
—
—
—
0
0
2345
20587
1.26
14.37
6.0
5.9
28.9
28.7
%
0.31
2181
19047
1275
10372
1.31
14.35
2.2
2.1
—
—
—
0
0
3576
33058
1.30
14.20
7.9
7.2
75.8
77.1
u/l
1.22
3352
30946
2312
20326
1.26
13.77
5.8
5.7
56.7
56.9
%
0.19
2153
18867
2448
21667
1.26
13.74
5.7
5.9
1.2
1.2
mmol/l
2.02
2073
18142
1686
14291
1.27
13.63
5.7
5.8
—
—
—
0
0
2490
22119
1.25
13.40
6.1
5.7
9.7
10.2
umol/l
3.15
2351
20826
2276
20044
1.25
13.10
6.2
6.1
8.3
8.3
%
0.12
2122
18643
2264
19928
1.25
13.09
5.9
5.9
2.7
2.8
%
1.45
2101
18421
1096
8884
1.30
12.39
1.5
1.4
2.1
2.3
g/l
1.24
588
5213
2189
19306
1.24
12.07
6.0
5.9
0.7
0.7
%
0.37
2031
17858
2752
24944
1.23
11.50
9.2
8.9
3.9
4.0
e9/l
1.29
2384
21780
4444
42734
1.39
10.97
14.3
13.3
19.8
21.0
mg/l
1.64
3502
33661
794
6253
1.32
10.95
2.7
2.7
4.1
4.5
e6/l
0.33
386
3160
2290
20431
1.23
10.90
3.9
3.9
—
—
—
0
0
2246
20056
1.22
10.42
2.3
2.3
81.2
79.1
nmol/l
2.66
1992
18065
583
4424
1.36
10.29
3.5
4.1
—
—
—
0
0
1419
12101
1.24
10.20
3.7
3.8
—
—
—
0
0
3486
32605
1.23
9.97
4.4
4.2
11.9
12.7
mm/h
3.06
3217
30139
3264
30337
1.22
9.84
5.0
4.6
—
—
—
0
0
1243
10490
1.25
9.74
3.4
3.5
94.5
94.9
%
0.20
1211
10176
197
1230
1.63
9.33
4.1
3.6
44.9
33.7
u/ml
0.29
190
1195
1299
11087
1.23
9.07
6.8
6.6
—
—
—
0
0
4281
41132
1.30
9.00
5.7
5.4
1.8
2.1
mu/l
1.78
3960
37951
782
6320
1.28
8.74
1.2
1.2
—
—
—
0
0
1685
14840
1.21
8.47
3.6
3.6
118.0
111.6
e6/l
0.08
1085
9970
2404
21931
1.19
8.01
5.7
5.7
1.9
1.9
e9/l
0.87
2101
19276
2424
22148
1.19
7.88
5.9
5.9
0.2
0.2
e9/l
0.48
2113
19397
4037
38648
1.24
7.83
16.3
14.5
38.9
38.9
%
0.04
3058
27699
1745
15537
1.19
7.56
3.9
3.2
2.4
2.4
mmol/l
1.12
1499
13451
1234
10660
1.21
7.40
1.3
1.3
1.2
1.6
u/ml
0.70
269
2859
1973
17786
1.18
7.33
2.0
2.0
100.5
98.8
pmol/l
0.72
886
8465
2339
21404
1.18
7.21
5.8
5.7
0.0
0.0
e9/l
0.20
1999
18413
2330
21316
1.18
7.20
5.7
5.7
0.6
0.6
e9/l
0.04
1994
18345
4494
43665
1.32
7.18
15.8
15.0
3.9
3.9
mmol/l
1.62
4368
42459
1493
13161
1.19
7.15
3.8
3.8
7.4
7.4
ph
0.13
235
2504
1384
12144
1.19
6.94
3.0
3.1
43.0
69.5
e6/l
0.97
991
9070
4481
43559
1.31
6.84
15.6
14.9
139.6
139.7
mmol/l
0.30
4367
42453
3157
29678
1.18
6.77
5.2
4.8
1257.1
2291.2
e6/l
0.80
53
352
1748
15678
1.18
6.75
7.5
7.7
1.2
1.2
inr
0.47
501
4585
1271
11095
1.20
6.72
2.9
2.9
—
—
—
0
0
1140
9860
1.20
6.65
1.7
1.7
1.0
1.1
mg/l
0.27
849
7471
253
3483
0.71
6.42
3.5
3.7
—
—
—
0
0
2179
19948
1.17
6.40
2.9
2.8
90.9
95.3
ug/l
0.47
2005
18449
427
3323
1.31
6.33
3.1
3.1
4.5
4.4
pmol/l
0.13
376
2936
64
324
1.99
6.25
1.1
1.1
—
—
—
0
0
818
6889
1.22
6.24
2.6
2.6
1.3
1.9
e6/l
0.71
414
3771
4612
45091
1.34
6.11
11.3
10.3
23.1
23.4
u/l
0.98
4454
43458
1522
13614
1.17
5.89
3.0
3.1
28.8
31.6
u/l
2.25
1430
12862
477
3808
1.28
5.83
2.0
2.1
0.2
0.2
g/l
0.01
444
3570
1266
11200
1.18
5.57
2.6
2.8
1112.1
1167.9
ng/l
0.17
1054
9531
502
4069
1.26
5.42
2.2
2.3
33.2
37.6
u/l
0.91
433
3418
473
3812
1.27
5.36
1.1
1.2
—
—
—
0
0
3773
36238
1.17
5.31
4.8
4.5
14.8
14.8
pmol/l
0.27
3441
33125
1272
11296
1.17
5.30
3.0
3.0
0.3
0.4
e6/l
1.74
890
8364
682
5764
1.21
4.98
2.0
2.1
119.4
118.3
ug/g
0.02
505
4434
2912
27507
1.14
4.95
3.0
2.9
40.0
41.0
u/l
0.24
2683
25478
15
41
3.67
4.92
1.5
2.7
1.0
0.9
u/field
0.16
15
41
1129
9991
1.17
4.86
3.8
4.0
—
—
—
0
0
457
3718
1.25
4.79
3.1
3.7
33.4
57.9
u/ml
4.18
444
3580
441
3592
1.25
4.58
3.1
3.1
76.1
80.9
ng/l
0.61
377
3012
4530
44366
1.25
4.53
13.3
12.6
—
—
—
0
0
383
3088
1.26
4.36
2.9
2.7
3.9
4.0
e9/l
0.88
289
2401
92
1413
0.64
4.25
7.5
9.2
—
—
—
0
0
88
555
1.60
4.21
1.1
1.1
—
—
—
0
0
4769
47065
1.37
4.14
21.9
20.0
261.0
263.4
e9/l
1.88
4645
45902
4772
47101
1.38
4.12
22.0
20.1
131.3
131.7
g/l
1.46
4712
46468
646
5538
1.19
4.04
1.9
1.9
—
—
—
0
0
1104
9876
1.15
4.04
1.5
1.5
22.1
21.5
nmol/l
0.71
923
8359
545
4604
1.21
4.00
4.0
3.7
9.3
29.2
ug/l
1.48
429
3609
4769
47090
1.36
3.88
21.9
20.0
4.4
4.4
e12/l
2.14
4634
45798
4768
47084
1.35
3.83
21.8
20.0
91.0
90.9
fl
0.23
4707
46443
4768
47085
1.35
3.82
21.8
19.9
30.1
30.1
pg
0.39
4707
46442
1818
16861
1.12
3.75
3.7
3.7
—
5.8
—
0
6
4768
47096
1.35
3.71
22.0
20.0
6.5
6.6
e9/l
2.45
4633
45793
107
733
1.47
3.57
3.9
3.7
60.8
44.5
u/ml
0.46
107
725
1648
15236
1.12
3.55
3.4
3.5
26.9
73.2
ng/l
0.79
1048
9617
739
6488
1.16
3.47
1.6
1.6
—
—
—
0
0
104
717
1.46
3.38
2.3
2.7
—
—
—
0
0
139
1012
1.38
3.35
1.1
1.1
—
—
—
0
0
532
4564
1.19
3.32
1.5
1.5
—
—
—
0
0
181
1377
1.33
3.29
1.2
1.2
—
—
—
0
0
881
7873
1.14
3.23
2.6
2.7
500.4
508.0
mosm/kgh2o
0.50
742
6650
106
741
1.44
3.22
1.6
1.6
—
—
—
0
0
870
7791
1.14
3.09
3.4
3.5
284.7
239.2
ng/l
0.29
626
5692
553
4790
1.17
3.09
2.3
2.4
5.5
7.1
umol/l
2.59
450
4046
119
857
1.40
3.08
1.8
1.7
—
—
—
0
0
652
5725
1.16
3.06
2.2
2.3
2.4
2.4
g/l
0.13
597
5248
71
465
1.53
3.00
1.1
1.2
—
—
—
0
0
88
603
1.47
2.99
1.1
1.1
—
—
—
0
0
355
2967
1.21
2.97
1.4
1.4
—
—
—
0
0
306
2522
1.23
2.94
1.4
1.3
30.4
32.4
iu/l
0.44
258
2187
556
4844
1.17
2.89
1.3
1.3
—
—
—
0
0
198
1557
1.28
2.87
2.2
2.2
3.6
3.7
g/l
0.38
136
1104
87
602
1.45
2.84
1.1
1.1
—
—
—
0
0
602
5286
1.16
2.83
2.3
2.4
21.4
21.7
%
0.17
511
4444
446
3826
1.18
2.81
1.4
1.4
—
—
—
0
0
829
7457
1.13
2.75
1.8
1.8
—
—
—
0
0
3660
35565
1.11
2.73
18.1
16.2
13.7
13.7
%
0.16
3602
34818
74
501
1.48
2.71
1.6
1.6
—
—
—
0
0
1948
18378
1.10
2.67
4.1
4.3
36.1
35.7
g/l
2.74
1785
16937
2530
24165
1.10
2.66
4.2
4.1
6.5
6.6
mmol/l
0.80
2353
22341
229
1852
1.25
2.65
2.2
2.5
0.2
0.3
e6/l
1.77
221
1787
54
343
1.58
2.64
2.1
2.9
10.0
26.2
mg/l
1.81
43
231
2299
21869
1.10
2.63
5.6
5.3
0.0
0.0
estimate
0.80
392
4001
184
1456
1.27
2.57
2.0
2.2
10.2
10.0
g/l
0.25
149
1200
158
1230
1.29
2.51
1.4
1.4
—
—
—
0
0
701
6275
1.14
2.51
2.3
2.3
12.5
12.9
umol/l
0.59
641
5756
110
813
1.36
2.51
1.2
1.2
—
—
—
0
0
2315
22067
1.09
2.48
4.1
4.0
0.0
0.0
estimate
1.57
393
4028
128
973
1.32
2.43
2.4
2.3
—
—
—
0
0
116
872
1.34
2.38
1.3
1.3
16.9
15.7
u/l
0.32
91
715
158
1241
1.28
2.37
2.0
2.0
39.1
37.8
g/l
2.00
131
1046
148
1156
1.29
2.32
1.1
1.2
—
—
—
0
0
135
1043
1.30
2.30
1.1
1.1
—
—
—
0
0
1432
13398
1.10
2.28
2.4
2.4
56.1
57.0
u/l
0.43
1293
12224
222
1825
1.23
2.26
8.8
7.5
24.5
24.4
mmol/l
0.12
203
1696
475
4176
1.15
2.23
1.9
2.1
373.7
379.0
nmol/l
0.23
424
3820
2270
21687
1.09
2.23
4.0
3.9
0.0
0.0
estimate
0.80
384
3985
203
1656
1.24
2.22
3.1
3.7
24.5
24.4
mmol/l
0.27
187
1483
242
2014
1.21
2.19
1.3
1.2
—
—
—
0
0
7
19
3.69
2.15
1.0
1.1
—
—
—
0
0
13
55
2.37
2.12
1.0
1.8
—
—
—
0
0
176
1427
1.24
2.06
1.2
1.3
65.2
38.6
u/ml
—
9
107
58
398
1.46
2.06
1.1
1.2
—
—
—
0
0
36
224
1.61
1.99
2.4
2.5
772.7
798.0
e6/l
0.06
21
96
102
777
1.32
1.97
1.4
1.4
0.3
0.4
nmol/l
1.22
78
597
1153
10747
1.10
1.97
2.3
2.3
3.0
3.0
mg/l
0.11
965
9190
183
1502
1.23
1.94
2.0
1.9
21.0
21.1
s
0.06
163
1277
160
1297
1.24
1.90
1.2
1.3
8.9
7.2
u/ml
0.12
27
236
25
143
1.75
1.88
1.0
1.1
—
—
—
0
0
10
223
0.45
1.83
1.8
1.3
60.2
64.1
%
—
5
26
328
2854
1.16
1.82
1.3
1.3
74.7
45.6
au/ml
—
10
126
180
1486
1.22
1.82
1.5
1.7
342.7
319.2
mu/l
0.30
162
1316
84
636
1.33
1.73
1.2
1.1
2.0
3.2
u/ml
0.82
39
278
232
1973
1.18
1.72
1.1
1.1
—
2.3
—
0
25
42
282
1.49
1.71
1.1
1.0
—
—
—
0
0
1233
11595
1.08
1.70
3.8
3.5
—
—
—
0
0
164
1352
1.22
1.70
1.4
1.4
266.5
290.6
ug/g
0.86
82
773
356
3134
1.15
1.70
2.4
2.4
26.9
26.6
au/ml
0.01
21
186
21
118
1.78
1.70
1.2
1.2
—
—
—
0
0
47
324
1.45
1.69
6.7
6.0
—
—
—
0
0
99
1262
0.78
1.68
2.8
3.6
1.3
1.3
mmol/l
0.12
99
1241
135
1096
1.24
1.63
1.2
1.3
25.7
40.6
u/ml
—
9
136
64
471
1.36
1.61
1.4
1.4
—
2.4
—
0
5
191
2259
0.84
1.61
5.4
6.7
25.3
24.8
mmol/l
0.84
186
2091
30
190
1.58
1.59
1.4
1.5
14.8
14.8
pmol/l
0.00
25
155
42
287
1.47
1.59
1.2
1.1
34.9
33.5
mmol/l
0.13
29
242
6
20
3.00
1.58
1.0
1.9
—
—
—
0
0
30
191
1.57
1.56
1.4
1.3
—
—
—
0
0
4191
41305
1.10
1.55
4.5
4.5
5.8
5.8
mmol/l
2.13
3791
37656
311
2734
1.15
1.54
2.3
2.3
—
—
—
0
0
39
265
1.48
1.53
1.0
1.0
0.5
1.0
u/ml
—
8
66
275
2400
1.15
1.51
1.4
1.4
—
—
—
0
0
112
900
1.25
1.50
3.3
3.5
22.7
23.9
mg/l
0.16
76
540
181
1529
1.19
1.49
1.7
1.7
—
—
—
0
0
102
812
1.26
1.49
1.3
1.4
28.6
31.2
u/l
0.33
81
673
118
1448
0.81
1.48
2.9
4.3
—
—
—
0
0
154
1285
1.20
1.46
1.2
1.3
3.4
5.3
u/ml
0.28
15
147
52
379
1.38
1.42
1.3
1.3
—
—
—
0
0
7
29
2.42
1.39
1.3
1.2
—
2.1
—
0
9
899
8418
1.08
1.38
3.2
2.8
2.5
2.5
mmol/l
0.38
781
7339
333
3730
0.89
1.38
4.1
3.4
1.2
1.2
mmol/l
0.08
281
3223
12
61
1.97
1.32
1.1
1.0
—
—
—
0
0
36
249
1.45
1.32
2.3
2.3
392.6
511.5
e6/l
1.16
29
203
364
3271
1.12
1.31
2.4
2.5
66.3
66.5
g/l
0.23
321
2936
43
308
1.40
1.31
1.1
1.1
7.8
9.6
iu/ml
—
10
71
327
2922
1.13
1.30
7.7
6.9
—
—
—
0
0
88
1096
0.80
1.30
2.7
3.9
3.9
3.8
mmol/l
1.59
83
1035
124
1027
1.21
1.30
3.8
4.5
—
—
—
0
0
5
18
2.78
1.28
1.0
1.1
—
—
—
0
0
1616
15492
1.06
1.28
3.4
3.2
—
—
—
0
0
211
1834
1.16
1.27
1.6
1.6
—
—
—
0
0
23
353
0.65
1.26
1.1
1.1
—
—
—
0
0
1235
11742
1.07
1.26
1.5
1.5
—
—
—
0
0
322
3583
0.89
1.22
4.2
4.0
0.8
0.9
%
0.15
84
916
5
19
2.63
1.21
1.0
1.0
—
—
—
0
0
24
156
1.54
1.19
1.2
1.1
—
0.4
g/l
—
0
8
36
255
1.41
1.19
3.5
3.6
—
—
—
0
0
8
38
2.11
1.18
1.1
1.5
—
—
—
0
0
26
173
1.51
1.17
1.4
1.3
—
—
—
0
0
368
3336
1.11
1.16
1.2
1.2
—
—
—
0
0
78
623
1.26
1.16
1.3
1.2
—
—
—
0
0
6
126
0.48
1.16
1.5
2.3
141.0
161.4
nmol/l
—
6
108
319
2870
1.12
1.16
1.3
1.3
154.1
180.6
u/ml
0.40
294
2662
171
1476
1.16
1.15
1.3
1.3
215.8
235.4
miu/ml
0.35
99
733
8
39
2.05
1.15
5.1
6.5
—
—
—
0
0
58
447
1.30
1.15
1.3
1.4
—
—
—
0
0
121
1015
1.20
1.14
1.4
1.4
—
—
—
0
0
49
369
1.33
1.14
1.3
1.2
—
—
—
0
0
1075
11310
0.94
1.14
3.0
3.1
969.3
470.9
mg/l
1.25
568
6438
57
440
1.30
1.12
2.1
2.6
—
—
—
0
0
28
192
1.46
1.11
1.5
1.6
2.1
2.0
umol/l
0.28
22
182
239
2120
1.13
1.11
2.0
2.0
—
—
—
0
0
30
209
1.44
1.10
2.2
2.6
—
31.4
—
0
5
185
1614
1.15
1.09
2.0
1.7
1.6
1.6
g/l
0.03
157
1367
531
4918
1.09
1.09
23.6
22.7
1.3
1.3
inr
0.20
71
715
1199
11446
1.06
1.08
1.6
1.6
1.3
1.3
mmol/l
1.92
996
9610
15
89
1.69
1.07
1.1
1.2
—
—
—
0
0
310
3425
0.90
1.06
4.2
4.0
0.1
0.2
%
0.88
78
850
33
236
1.40
1.06
3.8
3.7
—
—
—
0
0
35
253
1.39
1.06
1.4
1.3
—
1.6
—
0
20
80
650
1.23
1.05
1.6
1.4
2.8
4.1
ug/l
1.48
69
569
7
33
2.12
1.05
1.0
1.3
—
—
—
0
0
6
123
0.49
1.05
1.2
1.1
—
—
—
0
0
39
288
1.36
1.04
1.6
1.4
1422.2
1995.3
ml
—
6
64
24
162
1.48
1.04
1.2
1.1
568.6
382.0
ng/l
—
5
40
15
90
1.67
1.03
5.5
4.9
25.5
24.9
mmol/l
0.46
15
83
866
8192
1.07
1.03
1.3
1.3
8.3
12.7
u/ml
1.56
293
3217
11
60
1.84
1.02
1.0
1.0
—
—
—
0
0
11
60
1.84
1.02
1.0
1.0
—
—
—
0
0
11
60
1.84
1.02
1.0
1.0
—
—
—
0
0
905
8577
1.07
1.02
1.3
1.3
30.6
34.8
iu/ml
0.42
280
2772
155
1343
1.16
1.02
1.8
1.8
68.2
4.6
iu/l
0.50
49
498
62
491
1.27
1.02
5.0
4.5
49.4
94.3
u/ml
0.73
21
140
513
4762
1.09
1.01
1.8
1.7
—
—
—
0
0
680
6385
1.08
1.01
1.4
1.4
723.7
583.7
titre
0.70
150
1451
119
1011
1.18
1.00
1.4
1.4
—
—
—
0
0
296
2678
1.11
1.00
2.5
2.9
4.5
4.5
kpa
0.10
286
2592
172
1506
1.15
0.99
1.1
1.1
—
—
—
0
0
73
592
1.24
0.99
1.2
1.3
—
—
—
0
0
440
4063
1.09
0.99
1.4
1.4
—
—
—
0
0
443
4093
1.09
0.98
2.4
2.4
1.7
1.8
%
1.52
379
3598
33
240
1.38
0.98
2.3
2.3
0.2
0.2
e9/l
1.24
28
201
284
2568
1.11
0.98
1.3
1.2
—
—
—
0
0
9
157
0.57
0.98
1.2
1.2
—
—
—
0
0
270
2437
1.11
0.97
2.4
2.5
—
—
—
0
0
154
1341
1.15
0.96
2.6
3.5
25.4
25.1
mmol/l
0.74
138
1223
10
54
1.85
0.96
4.5
8.0
—
—
—
0
0
122
1044
1.17
0.96
1.5
1.5
—
—
—
0
0
52
407
1.28
0.95
2.5
2.5
—
—
—
0
0
152
1324
1.15
0.95
2.9
3.1
—
—
—
0
0
7
37
1.89
0.94
1.0
1.1
—
—
—
0
0
1099
10510
1.06
0.93
3.7
3.9
—
—
—
0
0
51
400
1.28
0.93
2.5
2.7
—
—
—
0
0
94
789
1.20
0.93
1.3
1.3
54.3
61.1
mmol/l
1.34
80
625
42
321
1.31
0.92
1.1
1.1
—
—
—
0
0
72
590
1.22
0.91
1.3
1.3
—
—
nmol/l
—
0
0
902
8584
1.06
0.91
2.4
2.5
7.0
7.9
e6/l
1.09
788
7463
43
331
1.30
0.90
2.2
2.2
1.7
2.1
u/field
0.34
18
137
65
528
1.23
0.89
1.8
1.5
—
—
—
0
0
64
519
1.24
0.89
1.1
1.2
—
—
—
0
0
280
3075
0.91
0.89
2.0
2.3
6.1
5.6
ug/l
0.25
227
2594
296
3241
0.91
0.89
4.3
4.1
0.1
0.5
%
1.17
73
722
616
5795
1.07
0.88
1.9
1.9
29.6
29.3
s
0.51
602
5597
12
71
1.69
0.88
1.2
1.1
—
—
—
0
0
4291
42520
1.07
0.88
4.9
4.8
2.8
2.8
mmol/l
0.00
3923
39040
9
155
0.58
0.88
3.9
2.0
—
—
—
0
0
78
648
1.21
0.87
1.1
1.1
—
—
—
0
0
30
220
1.37
0.87
1.0
1.1
3.5
5.6
u/ml
—
5
32
1140
11871
0.95
0.86
3.7
3.8
7.5
8.3
mg/mmol
0.21
604
6812
689
6515
1.07
0.86
2.7
2.9
0.8
0.8
mmol/l
0.04
630
6020
524
4908
1.08
0.85
1.5
1.4
—
—
—
0
0
55
680
0.81
0.84
1.4
2.0
0.8
0.8
nmol/l
0.23
48
569
77
642
1.20
0.84
1.3
1.3
103.0
113.5
u/ml
—
9
152
6
114
0.53
0.82
1.0
1.6
—
—
—
0
0
15
97
1.55
0.81
1.5
1.5
—
—
—
0
0
343
3169
1.09
0.80
6.6
5.6
1.2
1.3
mmol/l
0.40
333
3066
1308
12623
1.05
0.79
2.0
2.1
158.0
160.2
u/l
0.04
1223
11781
36
277
1.30
0.78
1.3
1.2
—
—
—
0
0
0
26
0.00
0.78
0.0
1.7
—
61.6
—
0
19
18
258
0.70
0.78
2.2
2.3
613.2
611.2
ml
0.01
12
180
1048
10064
1.05
0.78
2.2
2.3
3364.0
4343.2
umol/l
0.42
884
8598
4024
39833
1.05
0.77
3.9
3.8
1.2
1.2
mmol/l
3.39
3648
36247
0
27
0.00
0.77
0.0
2.8
—
887.4
—
0
27
20
140
1.43
0.76
2.4
2.6
—
—
—
0
0
47
377
1.25
0.75
2.3
2.1
1.0
1.2
e9/l
0.50
20
241
9
53
1.70
0.75
1.0
1.3
—
—
—
0
0
118
1033
1.15
0.74
1.3
1.3
—
—
—
0
0
7
38
1.84
0.73
2.3
1.2
—
—
—
0
0
1937
18890
1.04
0.73
9.4
9.1
0.0
0.0
e9/l
0.57
1522
15398
169
1516
1.12
0.73
1.5
1.4
—
—
—
0
0
5
25
2.00
0.72
1.0
1.6
—
—
—
0
0
59
489
1.21
0.71
2.6
2.8
—
—
—
0
0
5
26
1.92
0.70
1.0
1.0
—
—
—
0
0
75
637
1.18
0.70
1.3
1.3
59.8
58.2
u/ml
—
6
53
32
248
1.29
0.68
2.5
3.4
—
—
—
0
0
5
27
1.85
0.68
4.8
2.0
—
—
—
0
0
9
59
1.53
0.68
15.0
10.3
—
—
—
0
0
83
714
1.17
0.67
1.3
1.3
—
—
—
0
0
11
168
0.65
0.67
3.3
1.8
—
—
—
0
0
7
43
1.63
0.66
1.0
1.2
—
—
—
0
0
19
136
1.40
0.66
1.4
1.6
—
—
—
0
0
478
5055
0.94
0.64
1.9
1.8
—
—
—
0
0
80
690
1.16
0.64
1.1
1.1
9.9
15.9
au/ml
—
7
34
5
29
1.72
0.64
4.0
1.9
41.8
41.3
umol/l
—
5
29
5
29
1.72
0.64
1.0
1.0
—
—
—
0
0
101
887
1.14
0.63
2.0
2.2
130.8
126.9
g/l
0.85
62
632
215
2341
0.91
0.63
3.5
4.8
—
—
—
0
0
3631
35914
1.04
0.63
18.7
17.4
330.7
330.6
g/l
0.22
3607
35657
516
4893
1.06
0.63
4.4
4.7
1.1
1.0
mmol/l
0.43
463
4485
29
225
1.29
0.63
1.2
1.2
—
—
—
0
0
58
488
1.19
0.62
1.1
1.1
0.9
0.1
u/ml
0.62
12
99
347
3249
1.07
0.62
3.0
3.4
5.9
5.8
kpa
0.52
337
3160
229
2109
1.09
0.62
2.6
3.3
7.4
7.4
ph
1.74
28
299
167
1515
1.11
0.62
2.5
3.4
—
—
—
0
0
74
637
1.16
0.61
2.0
2.1
5.0
5.9
umol/l
0.39
41
462
18
130
1.39
0.61
1.2
1.3
—
—
—
0
0
1120
11566
0.96
0.61
4.6
4.4
0.0
0.0
estimate
0.35
392
4009
106
1195
0.88
0.60
4.9
6.0
1.2
1.2
mmol/l
0.13
100
1050
22
165
1.33
0.60
2.7
2.0
9.0
9.4
mmol/l
0.16
17
128
14
198
0.71
0.60
10.1
16.1
1333.3
1571.4
nmol/l
0.49
14
191
17
122
1.39
0.60
1.5
1.6
—
—
—
0
0
50
417
1.20
0.59
1.2
1.4
—
—
—
0
0
4174
41427
1.05
0.59
4.4
4.3
1.6
1.6
mmol/l
3.23
3806
38044
18
131
1.38
0.59
2.0
2.7
24.8
27.1
umol/l
0.41
13
98
14
97
1.44
0.59
1.2
1.1
0.8
0.6
umol/24h
—
5
45
14
97
1.44
0.59
1.2
1.4
—
—
—
0
0
4202
41716
1.05
0.58
4.4
4.3
4.9
4.9
mmol/l
0.92
3849
38512
37
300
1.24
0.58
2.0
2.0
42.7
42.4
%
—
8
38
14
196
0.71
0.57
1.9
2.2
528.2
503.0
min
—
9
150
6
36
1.67
0.56
1.0
1.3
—
—
—
0
0
241
2237
1.08
0.56
3.4
3.5
—
—
—
0
0
1180
12151
0.96
0.56
2.9
3.0
6.5
6.5
mmol/l
0.09
966
10137
5
87
0.57
0.56
1.0
1.2
3.8
3.1
mmol/l
—
5
79
50
592
0.84
0.56
1.5
1.5
—
—
—
0
0
6
37
1.62
0.55
1.2
1.1
—
—
—
0
0
230
2133
1.08
0.55
2.7
3.4
5.2
5.2
kpa
0.28
217
1975
260
2423
1.08
0.55
2.1
1.8
1.3
1.3
g/l
0.22
236
2201
19
251
0.76
0.55
1.0
1.0
859.6
730.5
ng/l
0.45
14
172
820
7906
1.04
0.54
1.8
1.7
1122.3
1195.0
nmol/l
1.34
585
5944
44
367
1.20
0.54
1.2
1.4
10.7
12.0
mmol/l
—
8
63
62
718
0.86
0.54
2.4
2.7
8.1
8.2
kpa
0.35
62
668
387
3662
1.06
0.53
1.3
1.2
168.1
156.5
iu/ml
0.18
135
1423
14
193
0.72
0.53
9.6
10.9
734.7
851.3
nmol/l
0.47
14
185
125
1134
1.10
0.50
1.3
1.2
150.0
193.4
titre
—
7
90
341
3225
1.06
0.49
3.1
3.4
2.0
2.1
mmol/l
0.01
298
2677
86
765
1.13
0.48
1.2
1.2
—
—
—
0
0
55
474
1.16
0.48
2.5
3.1
—
—
—
0
0
32
262
1.22
0.48
1.0
1.0
0.4
2.4
u/ml
—
10
78
7
111
0.63
0.48
2.1
2.3
—
139.8
—
0
17
913
9408
0.96
0.46
4.5
4.5
1.0
1.0
kg/l
1.35
131
1483
172
1594
1.08
0.45
1.1
1.1
—
—
—
0
0
25
201
1.25
0.44
1.1
1.1
—
—
—
0
0
24
192
1.25
0.44
4.0
2.9
7.4
7.4
ph
—
5
63
49
422
1.16
0.44
5.0
6.4
12.6
12.1
mg/l
0.36
43
389
29
351
0.83
0.44
1.1
1.1
—
—
—
0
0
5
31
1.61
0.43
2.2
2.1
—
—
—
0
0
91
821
1.11
0.42
2.8
3.3
0.7
0.8
nmol/l
2.04
71
637
313
3294
0.95
0.41
4.0
3.8
0.7
0.6
%
0.18
62
666
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
0.2
—
0
7
37
314
1.18
0.41
1.3
1.3
2.0
2.1
mmol/l
0.39
29
296
0
17
0.00
0.40
0.0
1.4
—
451.1
—
0
17
55
625
0.88
0.40
2.1
2.6
35.3
32.3
umol/l
0.30
46
532
17
132
1.29
0.40
1.6
1.8
—
—
—
0
0
33
278
1.19
0.39
1.7
2.0
9.3
10.8
%
1.38
33
278
5
35
1.43
0.39
1.2
1.2
—
—
—
0
0
313
3286
0.95
0.39
2.3
2.8
207.3
170.3
ng/l
0.77
276
2993
21
169
1.24
0.38
5.2
11.6
—
—
—
0
0
433
4159
1.05
0.38
1.6
1.6
—
—
—
0
0
8
114
0.70
0.37
1.5
1.8
—
—
—
0
0
57
641
0.89
0.37
1.1
1.5
—
—
—
0
0
2958
29292
1.02
0.36
3.7
3.6
—
—
—
0
0
47
412
1.14
0.36
2.7
3.7
—
—
—
0
0
85
933
0.91
0.36
1.4
1.4
1992.5
1287.1
e6/l
0.19
65
759
9
71
1.27
0.36
1.2
1.5
—
—
—
0
0
21
256
0.82
0.36
1.4
1.2
—
—
—
0
0
5
77
0.65
0.35
1.8
1.2
—
—
—
0
0
94
861
1.09
0.35
1.2
1.3
—
—
—
0
0
85
931
0.91
0.35
1.3
1.3
15.2
24.6
e6/l
0.60
64
711
38
329
1.16
0.35
1.2
1.3
0.1
1.4
u/ml
2.06
18
135
80
878
0.91
0.34
1.7
2.3
—
—
—
0
0
343
3575
0.96
0.33
1.3
1.3
—
—
—
0
0
324
3105
1.05
0.33
2.7
2.8
10.2
10.3
g/l
0.33
294
2839
143
1339
1.07
0.32
2.5
2.7
0.4
0.3
g/l
0.15
54
432
150
1407
1.07
0.32
2.3
1.8
0.2
0.2
g/l
0.42
139
1325
10
74
1.35
0.32
1.2
2.0
13.7
17.2
umol/l
—
10
74
10
74
1.35
0.32
1.3
1.1
—
—
—
0
0
13
101
1.29
0.31
2.1
2.7
—
—
—
0
0
83
903
0.92
0.31
2.4
2.4
—
—
—
0
0
7
100
0.70
0.30
1.4
1.3
—
—
—
0
0
22
184
1.20
0.30
1.7
2.4
87.4
159.7
umol/l
1.68
11
109
34
296
1.15
0.30
1.2
1.5
—
—
—
0
0
25
293
0.85
0.30
1.1
1.1
1.1
1.1
ratio
—
10
105
107
996
1.08
0.29
1.6
1.6
14893.3
10918.3
e6/l
0.37
79
711
317
3049
1.04
0.29
2.4
2.4
70.7
71.1
e9/l
0.06
234
2256
38
335
1.14
0.29
2.3
2.2
—
—
—
0
0
47
421
1.12
0.28
1.4
1.3
—
—
—
0
0
153
1447
1.06
0.27
2.3
1.8
1.2
1.2
g/l
0.03
142
1365
918
9365
0.98
0.27
1.7
1.6
81191273.5
30158772.5
pmol/l
1.04
739
7706
48
432
1.11
0.27
2.8
2.2
—
—
—
0
0
39
437
0.89
0.26
2.8
2.1
—
—
—
0
0
11
86
1.28
0.26
1.5
1.3
85.9
93.4
ng/l
0.21
11
86
5
71
0.70
0.26
2.4
1.7
—
—
—
0
0
10
77
1.30
0.26
1.0
1.1
99.5
74.0
ug/l
—
10
63
139
1314
1.06
0.26
1.1
1.1
2.4
7.1
u/ml
1.45
18
140
76
703
1.08
0.25
1.1
1.2
—
—
—
0
0
945
9627
0.98
0.25
4.1
4.3
—
—
—
0
0
1431
14510
0.98
0.25
2.8
2.8
—
—
—
0
0
316
3052
1.04
0.25
3.4
3.2
—
—
—
0
0
33
372
0.89
0.25
1.3
1.4
211441.2
90682.8
e6/l
0.33
23
241
212
2213
0.96
0.25
9.2
7.4
0.6
0.7
%
0.92
212
2202
70
756
0.92
0.24
2.4
2.4
19.2
72.8
ug/min
3.09
36
437
40
444
0.90
0.24
1.3
1.4
6.5
6.7
g/l
0.14
26
310
40
444
0.90
0.24
2.8
2.1
4.0
4.0
mmol/l
0.04
40
439
40
444
0.90
0.24
2.8
2.1
106.3
105.4
mmol/l
0.74
40
439
40
444
0.90
0.24
1.3
1.4
0.3
0.4
g/l
1.55
26
313
40
444
0.90
0.24
1.3
1.4
2.5
2.8
g/l
0.46
27
311
31
274
1.13
0.24
1.1
1.1
12.1
12.2
nmol/l
—
6
55
3876
38587
1.02
0.23
5.4
5.5
38.7
39.1
mmol/mol
2.43
3568
35602
40
360
1.11
0.23
1.2
1.3
1.0
1.5
nmol/l
1.88
33
289
21
243
0.86
0.23
1.5
1.6
1.3
1.1
promille
0.35
16
181
91
853
1.07
0.23
3.1
3.4
2.8
2.7
mmol/l
0.07
61
601
23
264
0.87
0.23
1.7
1.6
4.2
5.2
u/l
1.53
15
223
52
567
0.92
0.22
1.2
1.1
45.8
18031.3
iu/ml
0.55
17
132
247
2561
0.96
0.22
1.9
1.8
—
—
—
0
0
93
874
1.07
0.22
4.4
3.6
58.7
57.2
%
0.60
93
874
421
4100
1.03
0.22
6.8
6.3
1.3
1.2
mmol/l
0.15
353
3242
73
681
1.07
0.21
1.1
1.2
300.6
268.8
u/ml
0.32
41
430
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
24.3
—
0
7
460
4491
1.03
0.20
6.2
5.9
104.3
104.3
mmol/l
0.09
449
4402
19
164
1.16
0.20
1.2
1.6
—
—
—
0
0
64
596
1.07
0.20
1.1
1.1
2.4
3.6
u/ml
0.42
24
216
9
112
0.80
0.20
1.0
1.1
—
—
—
0
0
60
645
0.93
0.20
1.3
1.3
—
—
—
0
0
6
50
1.20
0.19
1.2
1.4
—
—
—
0
0
106
1006
1.05
0.19
2.9
3.3
7.4
7.4
ph
0.58
87
840
95
899
1.06
0.19
3.0
3.0
1.4
1.5
mg/l
0.38
83
827
44
404
1.09
0.19
4.2
4.2
8.5
7.1
mmol/l
0.98
37
332
61
569
1.07
0.19
1.7
2.1
—
—
—
0
0
80
754
1.06
0.18
1.7
1.5
—
—
—
0
0
389
3797
1.03
0.18
4.9
4.1
—
—
—
0
0
59
551
1.07
0.18
1.1
1.1
4.6
3.4
u/ml
0.15
22
206
119
1137
1.05
0.18
2.3
2.2
—
—
—
0
0
174
1678
1.04
0.17
1.6
1.6
5.8
15.2
u/ml
—
6
38
66
620
1.07
0.17
3.6
3.1
1.0
1.4
%
0.98
53
482
72
679
1.06
0.17
1.1
1.1
2.4
1.4
u/ml
0.19
21
154
41
444
0.92
0.17
1.3
1.4
—
—
—
0
0
10
120
0.83
0.16
1.1
1.5
—
—
—
0
0
76
720
1.06
0.16
1.1
1.1
0.8
0.9
u/ml
0.14
36
289
31
283
1.10
0.15
1.1
1.1
—
—
—
0
0
15
130
1.15
0.15
1.0
1.1
—
—
—
0
0
56
596
0.94
0.15
2.4
2.7
—
—
—
0
0
87
913
0.95
0.15
3.3
3.3
—
—
—
0
0
12
102
1.18
0.15
2.0
1.8
—
—
—
0
0
48
513
0.94
0.15
1.1
1.2
26.7
28.2
u/l
0.06
40
446
61
646
0.94
0.15
1.5
1.4
—
—
—
0
0
111
1066
1.04
0.14
1.4
1.4
—
—
—
0
0
307
3138
0.98
0.14
1.4
1.4
—
—
—
0
0
67
636
1.05
0.14
1.2
1.2
—
—
—
0
0
28
305
0.92
0.13
1.5
1.2
80.0
194.5
titre
—
5
65
8
99
0.81
0.13
1.0
1.1
—
—
—
0
0
8
99
0.81
0.13
1.0
1.1
—
—
—
0
0
8
99
0.81
0.13
1.0
1.1
—
—
—
0
0
11
94
1.17
0.13
1.2
1.1
—
—
—
0
0
9
109
0.83
0.13
1.3
1.5
—
—
—
0
0
81
846
0.96
0.13
1.2
1.1
0.7
1.0
u/ml
0.35
34
311
11
127
0.87
0.12
1.9
2.1
1569.8
756.5
e6/l
—
5
82
43
405
1.06
0.11
1.3
1.4
—
—
—
0
0
43
405
1.06
0.11
1.3
1.4
—
—
—
0
0
43
405
1.06
0.11
1.3
1.4
—
—
—
0
0
43
405
1.06
0.11
1.3
1.4
—
—
—
0
0
16
143
1.12
0.11
1.1
4.6
94.1
59.6
mg/l
—
9
98
126
1222
1.03
0.11
3.0
3.2
25.2
39.3
mg/l
1.66
94
991
126
1223
1.03
0.11
3.0
3.2
35.8
94.1
mg/l
0.68
94
995
15
134
1.12
0.10
1.2
1.1
—
—
—
0
0
25
270
0.93
0.10
1.1
1.1
—
—
—
0
0
170
1659
1.03
0.10
2.3
2.6
1.2
1.2
%
0.04
170
1645
13
115
1.13
0.10
2.2
2.0
9.3
10.1
mg/l
0.16
13
92
22
202
1.09
0.10
1.0
1.1
—
—
—
0
0
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
5
45
1.11
0.09
1.2
1.2
1.7
1.5
umol/24h
—
5
45
126
1226
1.03
0.09
1.9
2.1
425.7
614.6
ug/l
0.39
117
1128
66
634
1.04
0.09
1.2
1.2
—
—
—
0
0
354
3592
0.98
0.09
7.2
6.6
95.9
95.8
%
0.00
348
3451
66
635
1.04
0.09
1.4
1.2
2.3
4.2
u/ml
2.18
29
254
82
793
1.03
0.09
2.0
2.5
16.2
16.1
%
0.06
35
388
78
754
1.04
0.09
1.1
1.1
6.2
4.4
u/ml
0.31
40
365
416
4109
1.01
0.08
6.8
6.2
12.8
12.7
kpa
0.17
402
3899
22
204
1.08
0.08
1.2
1.9
—
—
—
0
0
6
57
1.05
0.08
1.3
2.4
—
—
—
0
0
97
998
0.97
0.08
1.6
1.7
—
—
—
0
0
90
927
0.97
0.08
1.2
1.2
3.7
3.7
mmol/l
0.19
83
877
13
144
0.90
0.08
1.2
1.7
25.3
28.2
%
0.46
13
134
416
4112
1.01
0.08
6.8
6.2
5.2
5.1
kpa
0.91
398
3909
7
64
1.09
0.08
1.0
1.0
—
—
—
0
0
11
123
0.89
0.08
3.5
3.2
—
—
—
0
0
23
246
0.93
0.08
1.0
1.1
—
—
—
0
0
121
1182
1.02
0.07
2.8
3.1
3.1
1.5
ratio
—
5
107
6
72
0.83
0.07
3.5
2.6
50.5
2220.3
u/l
—
6
66
6
73
0.82
0.07
4.3
5.1
—
—
—
0
0
6
74
0.81
0.07
1.0
1.5
30.7
21.6
%
—
6
64
8
78
1.03
0.07
1.3
1.0
—
—
—
0
0
9
85
1.06
0.07
1.0
1.1
—
288.0
—
0
5
137
1343
1.02
0.07
1.7
1.9
2.2
1.8
ug/l
0.22
113
1173
8
95
0.84
0.06
1.3
1.4
17.0
17.6
umol/l
—
8
84
35
366
0.96
0.06
1.2
1.4
5167.3
2189.2
e6/l
0.42
23
271
22
207
1.06
0.06
1.1
1.3
—
—
—
0
0
62
638
0.97
0.06
1.1
1.1
—
—
—
0
0
28
294
0.95
0.06
1.3
1.5
—
—
—
0
0
17
182
0.93
0.05
1.9
2.3
46.8
43.9
%
—
8
63
14
129
1.09
0.05
1.1
1.1
0.1
2.3
u/ml
—
6
66
12
131
0.92
0.05
1.2
2.1
1.3
2.1
ug/l
—
5
69
23
218
1.06
0.05
1.4
1.4
—
—
—
0
0
15
161
0.93
0.05
1.1
1.2
—
—
—
0
0
29
303
0.96
0.05
1.8
2.0
6.3
6.4
mmol/l
0.10
20
210
31
323
0.96
0.05
1.2
1.4
5605.9
66326.7
e6/l
1.75
14
183
127
1289
0.98
0.04
1.5
1.7
—
—
—
0
0
83
814
1.02
0.04
4.2
3.0
366.9
737.6
u/ml
0.43
74
734
18
170
1.06
0.04
2.2
1.9
—
—
—
0
0
39
378
1.03
0.04
2.9
3.0
50.9
56.9
%
0.76
29
246
22
210
1.05
0.03
3.4
3.0
—
—
—
0
0
61
597
1.02
0.03
1.7
1.5
51.5
52.7
mu/l
0.02
52
534
41
399
1.03
0.03
1.1
1.2
—
—
—
0
0
127
1285
0.99
0.03
1.5
1.7
—
—
—
0
0
116
1174
0.99
0.03
1.5
1.7
—
—
—
0
0
57
559
1.02
0.03
1.3
1.3
274.9
355.1
pmol/l
0.68
49
432
128
1293
0.99
0.02
1.5
1.7
—
—
—
0
0
45
460
0.98
0.02
1.5
1.4
279.4
276.0
mosm/kgh2o
0.47
33
354
15
142
1.06
0.02
1.3
1.2
—
—
—
0
0
52
510
1.02
0.02
1.6
1.6
51.6
55.2
%
0.27
36
305
33
321
1.03
0.02
1.2
1.6
—
—
—
0
0
18
188
0.96
0.02
1.0
1.5
—
—
—
0
0
191
1897
1.01
0.02
10.2
8.3
—
—
—
0
0
14
133
1.05
0.01
2.6
3.1
33.0
137.5
ng/l
—
5
47
16
153
1.05
0.01
1.4
2.7
—
—
—
0
0
18
187
0.96
0.01
1.3
1.4
129.7
128.4
nmol/l
0.05
18
187
126
1268
0.99
0.01
1.6
1.7
—
—
—
0
0
82
827
0.99
0.01
2.7
2.9
26.8
25.2
mmol/l
1.76
77
730
10
106
0.94
0.01
1.7
1.5
—
—
—
0
0
191
1917
1.00
0.00
2.3
2.1
6206.0
5371.4
u/l
0.14
89
774
10
95
1.05
0.00
1.9
1.8
—
—
—
0
0
28
278
1.01
0.00
2.7
3.5
21.1
26.7
mu/l
0.41
28
266
31
308
1.01
0.00
1.8
1.8
9.8
14.0
%
1.86
13
130
68
678
1.00
0.00
1.5
1.5
1.0
0.6
g/l
0.68
50
507
79
788
1.00
0.00
1.5
1.6
—
—
—
0
0
36
355
1.01
0.00
1.3
1.6
34.4
36.0
%
0.09
22
200
10
96
1.04
0.00
1.7
1.1
—
—
—
0
0
16
164
0.98
0.00
1.2
1.2
—
—
—
0
0
33
326
1.01
0.00
1.2
1.2
—
—
—
0
0
20
197
1.02
0.00
1.1
1.1
1884.1
1523.4
miu/ml
0.56
20
197
51
514
0.99
0.00
1.6
1.7
—
—
—
0
0
36
357
1.01
0.00
1.3
1.8
—
—
—
0
0
80
797
1.00
0.00
3.2
3.2
—
—
—
0
0
15
149
1.01
0.00
28.7
23.8
97.0
100.7
ug/l
0.09
15
121
19
189
1.01
0.00
1.2
1.2
—
—
—
0
0
146
1463
1.00
0.00
3.4
3.1
382.3
1134.8
u/ml
0.81
121
1240
32
321
1.00
0.00
1.2
1.1
250.9
225.9
mg/l
0.28
27
281
202
2019
1.00
0.00
1.3
1.3
1.3
1.1
u/ml
0.07
16
196
292
2921
1.00
0.00
5.4
6.3
9.0
9.0
mmol/l
0.04
277
2786
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
87.6
—
0
7
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.90
0.00
1.8
6.6
—
—
—
0
0
11
110
1.00
0.00
1.6
2.1
—
—
—
0
0
6
61
0.98
0.00
1.0
1.0
—
102.4
—
0
5
114
1140
1.00
0.00
1.7
2.1
11.0
11.3
mg/l
0.10
102
1057
8
84
0.95
0.00
1.4
1.2
—
—
—
0
0
6
64
0.94
0.00
1.0
1.1
—
—
—
0
0
5
52
0.96
0.00
1.0
1.1
—
—
—
0
0
8
82
0.98
0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1205.0
—
0
6
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
8.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
8
88
0.91
0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
13
130
1.00
0.00
1.0
1.2
41.0
37.9
g/l
—
7
61
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_BREAST and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_BREAST 1.045 [0.95, 1.15] 0.36
Birth year 0.999 [0.99, 1.01] 0.807

During the follow-up period (1.1.1998 — 31.12.2019), 1574 out of 17928 females with CD2_BENIGN_BREAST died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_BREAST.

N-year risk Females Males
1 0.102% No data
5 0.61% No data
10 1.804% No data
15 3.457% No data
20 6.259% No data

Relationships between endpoints

Index endpoint: CD2_BENIGN_BREAST – Benign neoplasm of breast

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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