MS-disease / Multiple Sclerosis

G6_MS

multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G35
  • Hospital discharge: ICD-9 340
  • Hospital discharge: ICD-8 34099
  • Cause of death: ICD-10 G35
  • Cause of death: ICD-9 340
  • Cause of death: ICD-8 34099
  • KELA reimbursements: KELA codes 109

3 out of 7 registries used, show all original rules.

2752

4. Check minimum number of events

None

2752

5. Include endpoints

None

2752

6. Filter based on genotype QC (FinnGen only)

2620

Control definitions (FinnGen only)

Control exclude
G6_DISSOTH, G6_OTHDEMYEL, G6_ADEM, G6_ENCEPHBACT, G6_ENCEPHOTH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G35-G37
Name in latin
Sclerosis multiplex

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19836 13288 6385
Only index persons 17256 11971 5285
Unadjusted period prevalence (%)
Whole population 0.31 0.38 0.18
Only index persons 0.37 0.44 0.20
Median age at first event (years)
Whole population 39.19 38.69 40.18
Only index persons 38.41 38.12 39.08

-FinnGen-

Key figures

All Female Male
Number of individuals 2620 1984 636
Unadjusted period prevalence (%) 0.67 0.78 0.32
Median age at first event (years) 38.02 36.86 41.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
2752
Matched controls
27519
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L03AB07
ATC
interferon beta-1a; parenteral
+∞
323.0
867
*
H46
ICD-10 Finland
Optic neuritis
308.8
323.0
694
30
109
Kela drug reimbursment
Multiple sclerosis
+∞
323.0
1876
*
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
+∞
323.0
758
*
L04AA31
ATC
teriflunomide; oral
+∞
323.0
408
*
TAB00
NOMESCO Finland
Lumbar puncture
24.3
323.0
878
521
L04AA27
ATC
fingolimod; oral
+∞
323.0
321
*
N86
ICPC
Multiple sclerosis
10262.7
323.0
762
*
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
+∞
323.0
1503
*
N04BB01
ATC
amantadine; oral
75.3
323.0
511
83
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
+∞
323.0
1579
*
164
Kela drug reimbursment
Fingolimod
+∞
323.0
438
*
N07XX09
ATC
[U] dimethyl fumarate; oral
+∞
323.0
333
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
23.2
323.0
1299
1022
L03AB08
ATC
interferon beta-1b; parenteral
+∞
323.0
382
*
L04AX07
ATC
dimethyl fumarate; oral
+∞
323.0
510
*
G35
ICD-10 Finland
Multiple sclerosis
4503599627370496.0
323.0
2676
*
L03AX13
ATC
glatiramer acetate; parenteral
+∞
323.0
672
*
353
Kela drug reimbursment
Cladribine and fingolimod
+∞
323.0
386
*
M03BX01
ATC
baclofen; systemic
30.9
307.6
417
158
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
21.6
223.1
336
176
2AB04
NOMESCO Finland
NA
589.0
222.7
218
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
30.7
215.5
292
106
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
+∞
211.2
200
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
20.7
209.5
320
174
XA800
NOMESCO Finland
Neuropsychological investigation
11.2
209.3
418
433
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
+∞
191.9
182
*
XCK00
NOMESCO Finland
Perimetry
8.6
182.8
425
572
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
+∞
181.3
172
*
R20.2
ICD-10 Finland
Paraesthesia of skin
6.3
178.9
523
982
G04BD09
ATC
trospium; oral
18.2
170.0
271
164
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.8
167.8
532
1100
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
166.3
746
2228
G04BD12
ATC
mirabegron; oral
6.2
163.5
483
912
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.5
161.7
534
1155
XKD00
NOMESCO Finland
Uroflowmetry
5.7
159.8
510
1058
34099
ICD-8 Finland
Multiple sclerosis
+∞
152.5
145
*
ZX120
NOMESCO Finland
Intravenous
5.3
150.3
512
1140
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
16.9
145.5
238
153
L03AB13
ATC
peginterferon beta-1a; parenteral
+∞
140.8
134
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.2
136.4
283
306
G04BD04
ATC
oxybutynin; oral, transdermal
8.2
136.4
324
442
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
6.4
131.4
374
662
N06BA07
ATC
modafinil; oral
55.4
127.6
152
29
N03AX12
ATC
gabapentin; oral
3.6
121.8
655
2210
XKC03
NOMESCO Finland
Water cystometry
10.1
118.2
245
263
UKC02
NOMESCO Finland
Cystoscopy
4.1
112.4
494
1393
4AA23
NOMESCO Finland
NA
+∞
112.2
107
*
N03AE01
ATC
clonazepam; systemic
5.3
108.5
357
747
H53.2
ICD-10 Finland
Diplopia
9.8
102.2
215
236
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
29.0
100.9
138
50
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.7
100.0
373
891
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
18.5
97.4
153
87
G04BD07
ATC
tolterodine; oral
7.3
97.3
246
364
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
10.2
96.5
198
207
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
96.4
92
*
R1250
NOMESCO Finland
Evaluation of functional capability
10.0
93.8
195
209
TKC22
NOMESCO Finland
Catheterisation instruction
14.1
88.1
154
115
G04BD08
ATC
solifenacin; oral
5.4
85.5
275
555
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
20.6
82.0
124
63
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
9.7
80.2
169
185
L04AA40
ATC
cladribine; oral
+∞
79.6
76
*
R35
ICD-10 Finland
Polyuria
5.3
77.8
252
511
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
27.8
77.6
107
40
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.5
76.0
293
715
SPAT1229
SPAT
Assessment of need for aid
4.4
73.2
285
701
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
24.8
72.4
103
43
N29
ICPC
Neurological sympt/complt other
10.9
71.0
140
135
H02AB04
ATC
methylprednisolone; systemic
2.8
70.4
528
2156
R33
ICD-10 Finland
Retention of urine
5.3
69.4
223
447
N03AX16
ATC
pregabalin; oral
2.3
66.0
730
3677
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.4
64.6
350
1141
Z2445
NOMESCO Finland
Psychologist
4.6
63.7
238
560
J01EA01
ATC
trimethoprim; systemic
2.1
59.5
821
4545
N28
ICPC
Limited function/disability (N)
13.9
58.9
103
77
Z3231
NOMESCO Finland
Registered nurse
2.1
58.6
804
4433
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
+∞
58.5
56
*
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
38.0
58.1
74
20
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
58.0
491
2131
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.7
57.9
209
474
Z3226
NOMESCO Finland
Physiotherapist
2.4
57.3
576
2739
L28
ICPC
Limited function/disability (L)
2.8
56.7
403
1576
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.6
56.2
279
845
XKD03
NOMESCO Finland
Urethral pressure profilometry
7.8
55.4
132
177
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
54.5
787
4409
TKC20
NOMESCO Finland
Catheterisation of bladder
4.1
53.9
223
577
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.0
52.2
133
197
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
5.5
50.9
158
303
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
7.5
50.7
124
173
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
33.8
50.6
66
20
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
3.3
50.3
276
901
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
47.9
50.3
61
13
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
135.0
50.0
53
*
G04BD11
ATC
fesoterodine; oral
6.3
49.7
138
230
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
+∞
49.1
47
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
12.9
49.0
88
70
N99
ICPC
Neurological disease other
12.2
48.3
89
75
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.9
48.3
140
247
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
12.4
48.1
88
73
L01BB04
ATC
cladribine; systemic
+∞
48.0
46
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.3
47.1
261
857
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
46.5
415
1836
R4110
NOMESCO Finland
Physiotherapy
2.0
46.3
714
4063
H53.1
ICD-10 Finland
Subjective visual disturbances
3.4
44.9
237
750
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.1
44.5
184
475
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.2
44.1
254
855
N03AF01
ATC
carbamazepine; oral, rectal
3.8
44.0
198
551
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
11.5
43.9
83
74
SPAT1231
SPAT
Assessment of adjustments needed in living environment
9.7
43.4
90
96
N05CF01
ATC
zopiclone; oral
1.9
43.3
836
5153
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
12.3
43.1
79
66
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
14.9
41.7
70
48
C10AC01
ATC
colestyramine; oral
5.3
41.6
132
260
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
19.5
41.4
63
33
4AA36
NOMESCO Finland
NA
+∞
40.7
39
*
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
403.2
40.2
40
*
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
13.2
40.1
71
55
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
5.9
39.8
115
202
H47.2
ICD-10 Finland
Optic atrophy
28.4
39.1
53
19
R4120
NOMESCO Finland
Occupational therapy
3.1
39.0
224
753
J01CA08
ATC
pivmecillinam; oral
1.7
36.7
1237
8974
L04AX01
ATC
azathioprine; systemic
3.3
36.3
191
602
RF120
NOMESCO Finland
NA
8.4
35.7
80
98
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
351.6
35.0
35
*
CS494
NOMESCO Finland
Other visual field testing
6.4
34.9
94
151
N30.0
ICD-10 Finland
Acute cystitis
2.2
34.6
405
2023
R42
ICD-10 Finland
Dizziness and giddiness
2.0
33.5
522
2931
3419X
ICD-9 Finland
Other demyelinating diseases of central nervous system, Demyelinating disease of central nervous system, unspecified
+∞
33.4
32
*
N04BD01
ATC
selegiline; oral
10.7
33.4
65
62
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
14.6
33.2
56
39
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
15.1
33.1
55
37
G50.0
ICD-10 Finland
Trigeminal neuralgia
6.4
33.1
89
143
A28
ICPC
Limited function/disability NOS
2.5
32.9
271
1137
A06AD11
ATC
lactulose; oral
2.4
32.4
311
1413
N06AX16
ATC
venlafaxine; oral
2.0
32.2
481
2654
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
19.5
31.8
48
25
SPAT1216
SPAT
Assessment of functional ability
2.2
31.6
341
1639
G04CA02
ATC
tamsulosin; oral
2.4
31.3
293
1312
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
21.8
30.9
45
21
H02AB07
ATC
prednisone; oral
2.1
29.4
376
1943
M03BX02
ATC
tizanidine; oral
1.6
29.4
1750
14389
U07
ICPC
Urine symptom/complaint other
3.2
29.0
162
533
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
81.0
28.8
32
*
Z43.5
ICD-10 Finland
Attention to cystostomy
29.6
28.5
38
13
L89
ICD-10 Finland
Decubitus ulcer and pressure area
8.5
28.2
62
74
N06AA09
ATC
amitriptyline; systemic
2.3
26.7
273
1275
F02.89
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere without information of additional symptoms
141.4
26.7
28
*
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.8
26.5
184
696
N04BC05
ATC
pramipexole; oral
2.7
26.4
188
723
N03AF02
ATC
oxcarbazepine; oral
3.6
26.4
125
363
SPAT1167
SPAT
Insertion of urinary catheter
5.7
26.3
77
139
34109
ICD-8 Finland
Other demyelinating diseases of central nervous system, Unspecified
+∞
26.1
25
*
U04
ICPC
Incontinence urine
3.5
26.0
126
373
R39.1
ICD-10 Finland
Other difficulties with micturition
4.7
24.7
85
184
U13
ICPC
Bladder symptom/complaint other
3.9
24.2
102
269
AA1AD
NOMESCO Finland
CT of head and brain
1.8
24.2
471
2829
A02BC02
ATC
pantoprazole; systemic
1.5
24.1
1591
13079
G81.9
ICD-10 Finland
Hemiplegia, unspecified
6.7
24.1
62
95
H48.1
ICD-10 Finland
Retrobulbar neuritis in diseases classified elsewhere
+∞
24.0
23
*
G37.8
ICD-10 Finland
Other specified demyelinating diseases of central nervous system
+∞
24.0
23
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
9.2
24.0
50
55
J01XX05
ATC
methenamine; oral
9.1
23.7
50
56
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
17.4
23.1
36
21
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
23.0
480
2942
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
22.7
251
1213
RF420
NOMESCO Finland
NA
5.4
22.2
67
126
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
22.1
265
1327
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
22.0
522
3321
U05
ICPC
Urination problems other
3.4
22.0
111
340
Z50.1
ICD-10 Finland
Other physical therapy
2.7
21.8
153
584
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
21.6
282
1461
RF410
NOMESCO Finland
NA
5.8
21.4
61
107
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
21.4
270
1379
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
21.4
546
3547
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
21.1
334
1864
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.3
20.9
78
185
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
20.8
885
6526
R03CA02
ATC
ephedrine; oral
19.6
20.8
31
16
H53.4
ICD-10 Finland
Visual field defects
4.5
20.7
74
168
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.6
20.5
157
631
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.9
20.5
130
467
Z3229
NOMESCO Finland
Other healthcare associate professional
2.2
20.5
209
971
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
20.4
660
4559
G04BD01
ATC
emepronium; systemic
9.4
20.1
41
44
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
7.3
20.0
48
67
G70.0
ICD-10 Finland
Myasthenia gravis
17.4
20.0
31
18
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.4
19.7
99
303
H57.1
ICD-10 Finland
Ocular pain
3.0
19.6
115
394
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
5.3
19.5
60
116
J01XE01
ATC
nitrofurantoin; oral
4.3
19.3
72
171
R32
ICD-10 Finland
Unspecified urinary incontinence
3.9
19.0
79
207
Z2446
NOMESCO Finland
Social worker
2.3
18.9
187
858
N18
ICPC
Paralysis/weakness
5.4
18.9
57
108
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.1
18.8
236
1201
G82.2
ICD-10 Finland
Paraplegia, unspecified
11.5
18.5
34
30
U28
ICPC
Limited function/disability (U)
8.8
18.4
39
45
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
18.4
595
4096
G04CA01
ATC
alfuzosin; oral
2.4
18.2
161
700
WW400
NOMESCO Finland
Plasmaferesis
25.2
18.2
25
10
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
18.1
929
7084
N07AA02
ATC
pyridostigmine; systemic
11.5
18.0
33
29
SPAT1325
SPAT
Vaccination
1.5
17.6
698
5031
J01MA02
ATC
ciprofloxacin; systemic
1.5
17.6
852
6414
G51.0
ICD-10 Finland
Bell palsy
3.5
17.4
81
234
G04BE03
ATC
sildenafil; oral
6.7
17.4
44
67
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
17.3
255
1385
359
Kela drug reimbursment
Mirabegroni
11.1
17.2
32
29
N06AB04
ATC
citalopram; systemic
1.6
17.2
570
3937
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.3
17.1
159
709
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.3
17.1
87
270
N06AX21
ATC
duloxetine; oral
1.8
16.9
316
1858
RS221
NOMESCO Finland
NA
4.4
16.6
60
139
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.3
16.5
83
256
N87
ICPC
Parkinsonism
7.5
16.4
38
51
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.0
16.2
96
332
G04BD10
ATC
darifenacin; oral
8.4
16.2
35
42
XCK10
NOMESCO Finland
Photography of fundus of eye
2.0
16.0
203
1038
R15
ICD-10 Finland
Faecal incontinence
3.6
15.8
71
200
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
15.8
249
1383
6BA02
NOMESCO Finland
NA
12.3
15.8
28
23
G04BDXX
ATC
NA
12.3
15.8
28
23
N30.9
ICD-10 Finland
Cystitis, unspecified
2.3
15.8
150
677
N07AA03
ATC
distigmine; systemic
15.7
15.7
25
16
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
10.4
15.7
30
29
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
4.6
15.6
54
120
SPAT1262
SPAT
Handing over of treatment supplies
1.7
15.4
363
2285
Z93.5
ICD-10 Finland
Cystostomy status
38.3
15.4
19
5
R20.0
ICD-10 Finland
Anaesthesia of skin
6.1
15.3
41
68
119
Kela drug reimbursment
Trigeminal neuralgia or glossofaryngeusneuralgia
10.9
15.0
28
26
R20.1
ICD-10 Finland
Hypoaesthesia of skin
7.4
14.9
35
48
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
15.1
14.9
24
16
R51.80
ICD-10 Finland
Headache
1.6
14.8
407
2675
K59.09
ICD-10 Finland
Constipation, unspecified
2.4
14.8
126
537
K59.0
ICD-10 Finland
Constipation
2.5
14.7
117
482
G04BE01
ATC
alprostadil; parenteral, urethral
6.9
14.7
36
53
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
14.6
283
1683
Z2221
NOMESCO Finland
Medical doctor
1.5
14.5
708
5294
RF432
NOMESCO Finland
NA
36.2
14.4
18
5
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.4
14.4
119
501
G04BD
ATC
Drugs for urinary frequency and incontinence
17.0
14.3
22
13
U08
ICPC
Urinary retention
5.9
14.2
39
67
U29
ICPC
Urinary symptom/complaint other
3.2
13.9
73
233
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.2
13.7
52
127
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.0
13.7
54
137
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
3.7
13.5
58
159
36702
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica. Papillitis
140.6
13.5
14
*
108
Kela drug reimbursment
Myasthenia gravis
13.8
13.2
22
16
RS340
NOMESCO Finland
NA
9.1
13.2
27
30
N02BE01
ATC
paracetamol; systemic, rectal
1.4
13.2
2182
20030
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
5.5
13.1
38
70
H30.2
ICD-10 Finland
Posterior cyclitis
12.2
13.1
23
19
RS121
NOMESCO Finland
NA
7.1
13.0
31
44
ABD40
NOMESCO Finland
Implantation of spinal injection device
28.5
12.9
17
6
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
12.9
210
1180
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
50.2
12.8
15
*
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.9
12.8
52
136
J01MA06
ATC
norfloxacin; oral
1.6
12.5
322
2072
G37.0
ICD-10 Finland
Diffuse sclerosis
+∞
12.5
12
*
S97
ICPC
Chronic ulcer skin
2.5
12.5
97
397
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.6
12.4
56
160
G20
ICD-10 Finland
Parkinson disease
3.7
12.4
53
145
R5110
SPAT
NA
3.3
12.4
60
182
RS222
NOMESCO Finland
NA
4.4
12.3
43
98
R47.1
ICD-10 Finland
Dysarthria and anarthria
7.0
12.1
29
42
R13
ICD-10 Finland
Dysphagia
2.1
12.0
131
632
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.1
11.7
64
212
U02
ICPC
Urinary frequency/urgency
1.6
11.7
292
1869
RF122
NOMESCO Finland
NA
12.6
11.6
20
16
3773A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[PAPILLITIS OPTICA]
65.2
11.6
13
*
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
11.6
228
1360
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
3.2
11.5
60
193
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.7
11.4
271
1707
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.2
11.4
57
178
N07AB01
ATC
carbachol; systemic
15.1
11.3
18
12
N03AX09
ATC
lamotrigine; oral
1.9
11.2
160
859
G61.9
ICD-10 Finland
Inflammatory polyneuropathy, unspecified
25.1
11.1
15
6
R31
ICD-10 Finland
Unspecified haematuria
2.0
11.0
143
740
AAH30
NOMESCO Finland
Thermal destruction of cranial nerve
43.5
10.9
13
*
U71
ICPC
Cystitis/urinary infection other
2.0
10.8
145
761
N06AX11
ATC
mirtazapine; oral
1.4
10.8
758
5999
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.4
10.7
51
154
SPAT1260
SPAT
Consultation of another employee
1.5
10.6
371
2574
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.2
10.5
102
468
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.5
10.5
84
348
G61.0
ICD-10 Finland
Guillain-Barré syndrome
9.2
10.5
21
23
1DB07
NOMESCO Finland
NA
110.4
10.4
11
*
34108
ICD-8 Finland
Other demyelinating diseases of central nervous system, Alii definiti
+∞
10.4
10
*
G36.8
ICD-10 Finland
Other specified acute disseminated demyelination
+∞
10.4
10
*
SPAT1293
SPAT
Other function in accordance with rehabilitation guidance nomenclature
5.9
10.4
28
48
R5599
NOMESCO Finland
Other rehabilitation service
2.8
10.4
66
242
J01MA12
ATC
levofloxacin; systemic
1.5
10.3
354
2441
XA412
NOMESCO Finland
VEP
32.6
10.3
13
*
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
5.1
10.3
31
61
G61.8
ICD-10 Finland
Other inflammatory polyneuropathies
23.4
10.2
14
6
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
10.2
658
5127
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
4.4
10.1
35
80
H52.1
ICD-10 Finland
Myopia
2.2
10.1
104
492
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.1
10.0
119
593
ZXA10
NOMESCO Finland
Bilateral
1.5
9.9
352
2447
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
4.0
9.9
38
96
N02AX02
ATC
tramadol; systemic, rectal
1.3
9.9
865
7066
SPAT1263
SPAT
Sampling
1.3
9.8
1005
8393
N06
ICPC
Sensation disturbance other
3.8
9.8
40
107
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.0
9.6
116
584
J01DB01
ATC
cefalexin; oral
1.3
9.6
2114
19591
J01MA01
ATC
ofloxacin; systemic
1.8
9.6
165
944
M05BA04
ATC
alendronic acid; oral
2.0
9.6
123
637
RF210
NOMESCO Finland
NA
2.4
9.6
79
336
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.5
9.6
311
2117
F05
ICPC
Visual disturbance other
2.7
9.6
61
225
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
9.5
182
1078
J05AB01
ATC
aciclovir; systemic
1.4
9.5
498
3736
ZXY02
NOMESCO Finland
Neuropsychologist
5.0
9.4
29
59
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
12.4
9.3
16
13
Z73.6
ICD-10 Finland
Limitation of activities due to disability
5.3
9.3
27
51
R60.0
ICD-10 Finland
Localized oedema
1.7
9.3
197
1200
J05AB11
ATC
valaciclovir; oral
1.5
9.2
307
2105
R27.0
ICD-10 Finland
Ataxia, unspecified
7.3
9.2
21
29
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
4.4
9.2
32
74
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
7.7
9.1
20
26
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
2.9
9.1
54
191
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
9.1
777
6310
SPAT1234
SPAT
Support of social functional capacity
2.2
9.1
89
412
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
9.0
9.0
18
20
H50.52
ICD-10 Finland
Exophoria
3.8
8.8
35
92
XKW99
NOMESCO Finland
Other physiological examination of urinary or male genital system
5.9
8.7
23
39
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.0
8.7
110
567
N06AB10
ATC
escitalopram; oral
1.4
8.7
547
4234
H02AB06
ATC
prednisolone; systemic
1.3
8.5
1024
8692
SPAT1254
SPAT
Administration of medicine
1.5
8.4
268
1817
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
6.0
8.4
22
37
R53
ICD-10 Finland
Malaise and fatigue
1.4
8.4
443
3325
NA1BM
NOMESCO Finland
Cervical spine MRI examination with 3 Tesla magnet
7.9
8.4
18
23
SPAT1281
SPAT
Other administrative function
1.7
8.3
174
1059
H02AB02
ATC
dexamethasone; systemic
0.5
8.3
71
1346
XA402
NOMESCO Finland
ENMG
2.4
8.2
67
284
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
1.9
8.2
118
637
R30.1
ICD-10 Finland
Vesical tenesmus
3.2
8.1
41
131
G83.9
ICD-10 Finland
Paralytic syndrome, unspecified
17.2
8.1
12
7
KCW98
NOMESCO Finland
Other transluminal endoscopic operation on bladder
11.7
8.1
14
12
U01
ICPC
Dysuria/painful urination
1.7
8.0
168
1027
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.7
8.0
149
879
XKX00
NOMESCO Finland
Pelvic floor electromyography
7.2
8.0
18
25
A02BA02
ATC
ranitidine; systemic
1.4
7.9
361
2633
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
7.9
125
698
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
7.9
322
2301
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
3.3
7.9
38
118
T83.0
ICD-10 Finland
Mechanical complication of urinary (indwelling) catheter
45.1
7.7
9
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.5
7.7
239
1609
N05BA01
ATC
diazepam; systemic, rectal
1.5
7.7
275
1912
RF310
NOMESCO Finland
NA
6.4
7.7
19
30
M05BX04
ATC
denosumab; parenteral
2.2
7.7
72
328
H20.1
ICD-10 Finland
Chronic iridocyclitis
3.6
7.6
32
89
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
3.8
7.6
30
79
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
18.4
7.6
11
6
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
7.6
126
2006
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
3.1
7.5
38
122
RF312
NOMESCO Finland
NA
10.0
7.5
14
14
G83.1
ICD-10 Finland
Monoplegia of lower limb
10.0
7.5
14
14
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
4.6
7.5
24
52
TKC10
SPAT
NA
80.3
7.4
8
*
SPAT1301
SPAT
No procedures
1.3
7.4
653
5304
D12
ICPC
Constipation
2.4
7.3
58
244
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.8
7.3
122
697
3418X
ICD-9 Finland
Other demyelinating diseases of central nervous system
+∞
7.3
7
*
Z74.0
ICD-10 Finland
Need for assistance due to reduced mobility
+∞
7.3
7
*
4AA34
NOMESCO Finland
NA
+∞
7.3
7
*
G37.1
ICD-10 Finland
Central demyelination of corpus callosum
+∞
7.3
7
*
H01AA02
ATC
tetracosactide; parenteral
+∞
7.3
7
*
SPAT1172
SPAT
Guidance concerning hydration
3.2
7.3
35
109
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
7.3
167
1045
A04
ICPC
Weakness/tiredness general
1.5
7.3
264
1845
A04AA55
ATC
palonosetron, combinations; systemic
0.2
7.2
10
405
D17
ICPC
Incontinence of bowel
5.4
7.2
20
37
SPAT1312
SPAT
General health counselling
1.3
7.2
726
6000
F43.29
ICD-10 Finland
Adaptation disorder UNS
2.3
7.1
65
291
W19
ICD-10 Finland
Unspecified fall
1.6
7.1
175
1115
R2110
NOMESCO Finland
Giving the first information
1.6
7.1
181
1164
K07
ICPC
Swollen ankles/oedema
2.3
7.1
63
282
RS130
NOMESCO Finland
NA
5.6
7.1
19
34
L17
ICPC
Foot/toe symptom/complaint
1.3
7.0
493
3870
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
6.3
6.9
17
27
N86
ICD-10 Finland
Erosion and ectropion of cervix uteri
5.5
6.9
19
35
R30.0
ICD-10 Finland
Dysuria
2.0
6.9
81
409
R26.0
ICD-10 Finland
Ataxic gait
13.8
6.9
11
8
G11.9
ICD-10 Finland
Hereditary ataxia, unspecified
13.8
6.9
11
8
SPAT1125
SPAT
Stoma care and guidance
4.4
6.8
23
53
SPAT1171
SPAT
Bladder puncture
40.1
6.8
8
*
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
3.7
6.8
27
73
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
3.7
6.8
27
73
G04AC01
ATC
NA
2.1
6.8
70
334
34400
ICD-8 Finland
Other cerebral paralysis, Hemiplegia NUD
16.7
6.7
10
6
RF311
NOMESCO Finland
NA
16.7
6.7
10
6
KH1AT
NOMESCO Finland
Urinary tract cathetrisation with ultrasound guidance
22.6
6.7
9
*
N03AX14
ATC
levetiracetam; systemic
2.2
6.7
60
271
183
Kela drug reimbursment
Lamotrigin and topiramate
3.1
6.6
33
106
U07.2
ICD-10 Finland
COVID-19, virus not identified
0.7
6.6
315
4134
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.2
6.6
937
8054
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
6.6
260
1843
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
2.1
6.6
72
353
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
2.5
6.6
50
206
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
6.6
802
6771
A29
ICPC
General symptom/complaint other
1.5
6.6
204
1379
H81.4
ICD-10 Finland
Vertigo of central origin
4.8
6.5
20
42
N04BC04
ATC
ropinirole; oral
4.8
6.5
20
42
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
6.5
249
1760
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
3.7
6.5
26
71
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
2.8
6.5
38
136
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
6.4
133
812
3499X
ICD-9 Finland
Other and unspecified disorders of the nervous system, Unspecified disorders of nervous system
70.0
6.4
7
*
R83.4
ICD-10 Finland
Abnormal findings in cerebrospinal fluid, Abnormal immunological findings
70.0
6.4
7
*
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
4.3
6.4
22
52
KCE02
NOMESCO Finland
Transluminal endoscopic extraction of calculus from bladder
7.4
6.4
14
19
G04BE08
ATC
tadalafil; oral
14.3
6.4
10
7
N27
ICPC
Fear of neurological disease other
3.5
6.4
27
77
ZY010
NOMESCO Finland
Hospital outpatient
1.7
6.3
132
808
M48.0
ICD-10 Finland
Spinal stenosis
1.6
6.3
165
1071
D21
ICPC
Swallowing problem
3.5
6.3
27
78
R5130
SPAT
NA
18.0
6.3
9
5
Z46.6
ICD-10 Finland
Fitting and adjustment of urinary device
+∞
6.2
6
*
A06AC51
ATC
ispaghula, combinations; systemic
1.8
6.2
96
536
A46
ICD-10 Finland
Erysipelas
1.5
6.2
206
1411
K59.01
ICD-10 Finland
Constipation outlet obstruction type
3.1
6.2
31
101
XX1XW
NOMESCO Finland
Extensive written report from radiologist
2.4
6.2
47
194
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
2.6
6.1
41
159
A02BA04
ATC
nizatidine; systemic
1.7
6.1
127
777
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
7.7
6.1
13
17
H52.2
ICD-10 Finland
Astigmatism
2.8
6.1
36
130
G04BX05
ATC
NA
12.5
6.1
10
8
G96.9
ICD-10 Finland
Disorder of central nervous system, unspecified
12.5
6.1
10
8
U72
ICPC
Urethritis
2.2
6.0
55
249

Mortality – FinRegistry

Association

Association between endpoint G6_MS and mortality.

Females

Parameter HR [95% CI] p-value
G6_MS 1.952 [1.74, 2.19] < 0.001
Birth year 0.998 [0.99, 1.01] 0.613

During the follow-up period (1.1.1998 — 31.12.2019), 690 out of 8943 females with G6_MS died.

Males

Parameter HR [95% CI] p-value
G6_MS 1.862 [1.65, 2.1] < 0.001
Birth year 0.989 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 4008 males with G6_MS died.

Mortality risk

Mortality risk for people of age

years, who have G6_MS.

N-year risk Females Males
1 0.221% 0.428%
5 1.32% 2.309%
10 3.478% 5.606%
15 6.353% 10.683%
20 10.966% 17.637%

Relationships between endpoints

Index endpoint: G6_MS – MS-disease / Multiple Sclerosis

GWS hits: 9

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data