multiple sclerosis: A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
3147 |
4. Check minimum number of eventsNone |
3147 |
5. Include endpointsNone |
3147 |
6. Filter based on genotype QC (FinnGen only) |
3002 |
Control definitions (FinnGen only)
- Control exclude
- G6_DISSOTH, G6_OTHDEMYEL, G6_ADEM, G6_ENCEPHBACT, G6_ENCEPHOTH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G35-G37
- Name in latin
- Sclerosis multiplex
Similar endpoints
↥List of similar endpoints to
MS-disease / Multiple Sclerosis
based on the number of shared cases.
Similar with more cases:
- Demyelinating diseases of the central nervous system
- Autoimmune diseases related-to ILD
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Neurological diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19836 | 13288 | 6385 |
| Only index persons | 17256 | 11971 | 5285 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.31 | 0.38 | 0.18 |
| Only index persons | 0.37 | 0.44 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 39.19 | 38.69 | 40.18 |
| Only index persons | 38.41 | 38.12 | 39.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3002 | 2256 | 746 |
| Unadjusted period prevalence (%) | 0.69 | 0.80 | 0.34 |
| Median age at first event (years) | 38.05 | 37.00 | 41.23 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3147
- Matched controls
- 31470
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N06BA07
ATC
modafinil; oral
48.2
318.4
186
41
R20.2
ICD-10 Finland
Paraesthesia of skin
6.0
311.2
635
1274
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
12243.2
307.7
896
*
164
Kela drug reimbursment
Fingolimod
+∞
307.7
521
*
M03BX01
ATC
baclofen; systemic
32.5
307.7
528
194
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
+∞
307.7
1853
*
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
18.1
307.7
375
233
XA800
NOMESCO Finland
Neuropsychological investigation
11.6
307.7
530
538
N86
ICPC
Multiple sclerosis
2243.9
307.7
939
6
L04AA27
ATC
[U] fingolimod
+∞
307.7
368
*
H46
ICD-10 Finland
Optic neuritis
192.5
307.7
804
56
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
+∞
307.7
1748
*
L04AX07
ATC
dimethyl fumarate; oral
+∞
307.7
604
*
TAB00
NOMESCO Finland
Lumbar puncture
24.9
307.7
1030
604
L03AX13
ATC
glatiramer acetate; parenteral
+∞
307.7
766
*
109
Kela drug reimbursment
Multiple sclerosis
+∞
307.7
2165
*
G04BD09
ATC
trospium; oral
18.7
307.7
303
178
N07XX09
ATC
[U] dimethyl fumarate
+∞
307.7
366
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.5
307.7
754
1458
G35
ICD-10 Finland
Multiple sclerosis
4503599627370496.0
307.7
3065
5
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
16.4
307.7
294
196
XKD06
NOMESCO Finland
Physiologic investigation of micturition
18.0
307.7
367
229
XCK00
NOMESCO Finland
Perimetry
9.1
307.7
480
613
L04AA31
ATC
[U] teriflunomide
+∞
307.7
463
*
2AB04, ,
NOMESCO Finland
224.3
307.7
248
12
L03AB07
ATC
interferon beta-1a; parenteral
+∞
307.7
964
*
353
Kela drug reimbursment
Cladribine and fingolimod
+∞
307.7
468
*
G04BD12
ATC
mirabegron; oral
6.3
307.7
657
1271
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
36.0
307.7
350
109
L03AB08
ATC
interferon beta-1b; parenteral
+∞
307.7
417
*
N04BB01
ATC
amantadine; oral
68.3
307.7
613
111
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
22.5
307.7
1530
1271
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.5
306.3
355
376
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
33.2
278.1
179
57
XKD00
NOMESCO Finland
Uroflowmetry
5.7
274.6
590
1234
ZX120
NOMESCO Finland
Intravenous
5.4
268.7
613
1351
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
6.5
255.0
457
802
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.2
252.5
601
1370
G04BD04
ATC
oxybutynin; oral, transdermal
7.6
244.3
371
546
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
19.2
242.0
192
106
XKC03
NOMESCO Finland
Water cystometry
10.7
241.9
273
277
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
+∞
232.2
220
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.8
224.8
890
2962
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
+∞
222.6
211
*
R1250
NOMESCO Finland
Evaluation of functional capability
10.4
216.2
248
257
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
+∞
211.9
201
*
TKC22
NOMESCO Finland
Catheterisation instruction
15.7
210.6
185
125
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
29.8
206.1
137
48
N03AE01
ATC
clonazepam; systemic
5.7
197.9
404
797
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
9.0
188.7
242
290
L04AK02
ATC
teriflunomide; oral
+∞
188.5
179
*
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
18.6
188.2
151
85
G04BD07
ATC
tolterodine; oral
7.2
185.0
289
436
UKC02
NOMESCO Finland
Cystoscopy
4.1
183.4
591
1685
L03AB13
ATC
peginterferon beta-1a; parenteral
+∞
178.9
170
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
10.6
177.5
199
199
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
4.6
177.4
472
1163
34099
ICD-8 Finland
Multiple sclerosis
+∞
167.2
159
*
G04BD08
ATC
solifenacin; oral
5.7
165.1
329
632
H53.2
ICD-10 Finland
Diplopia
7.5
164.9
247
355
N03AX12
ATC
[U] gabapentin; oral
3.3
163.1
789
2920
L04AG12
ATC
ofatumumab; parenteral
+∞
157.6
150
*
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
56.6
155.9
88
16
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
20.6
155.7
119
60
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
35.0
150.3
95
28
L04AE01
ATC
fingolimod; oral
+∞
141.7
135
*
N28
ICPC
Limited function/disability (N)
12.5
139.5
139
116
4AA23, ,
NOMESCO Finland
1355.6
134.4
130
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
15.9
132.9
115
75
SPAT1229
SPAT
Assessment of need for aid
4.6
130.3
329
771
L04AA40
ATC
cladribine; oral
+∞
130.1
124
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.5
129.1
344
841
H02AB04
ATC
methylprednisolone; systemic
3.1
128.8
663
2512
N29
ICPC
Neurological sympt/complt other
8.9
127.8
163
193
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
64.1
124.9
69
11
R35
ICD-10 Finland
Polyuria
4.7
122.0
305
708
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
121.6
116
*
L04AA52
ATC
[U] ofatumumab; parenteral
+∞
119.5
114
*
G04BD11
ATC
fesoterodine; oral
8.6
118.6
155
189
R33
ICD-10 Finland
Retention of urine
4.9
116.9
270
587
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.7
109.4
156
211
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
11.0
108.5
117
110
L28
ICPC
Limited function/disability (L)
2.9
105.9
575
2226
Z2445
NOMESCO Finland
Psychologist
4.5
105.5
270
637
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
7.8
103.0
145
193
XKD03
NOMESCO Finland
Urethral pressure profilometry
7.7
102.1
145
195
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
11.8
100.2
103
90
N99
ICPC
Neurological disease other
10.8
99.2
108
103
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
5.7
98.0
190
353
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.3
97.5
408
1354
H47.2
ICD-10 Finland
Optic atrophy
25.3
95.6
67
27
TKC20
NOMESCO Finland
Catheterisation of bladder
4.2
92.6
261
662
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
10.7
92.2
101
97
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
19.9
90.5
70
36
SPAT1215
SPAT
Assessment of need for medical rehabilitation
4.4
87.5
231
557
J01EA01
ATC
trimethoprim; systemic
2.2
85.9
1008
5531
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
29.0
85.2
57
20
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.2
83.0
176
354
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.3
82.9
349
1158
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
12.0
82.7
84
72
C10AC01
ATC
colestyramine; oral
5.3
82.1
169
331
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
16.9
81.6
68
41
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
14.6
81.1
73
51
Z3226
NOMESCO Finland
Physiotherapist
2.4
81.1
673
3180
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
4.1
80.7
232
596
SPAT1231
SPAT
Assessment of adjustments needed in living environment
9.2
80.4
98
109
N03AX16
ATC
[U] pregabalin
2.3
80.2
835
4345
R4120
NOMESCO Finland
Occupational therapy
3.4
79.1
305
958
Z3231
NOMESCO Finland
Registered nurse
2.2
78.5
932
5106
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
10.5
78.5
87
85
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
78.0
549
2400
L04AX01
ATC
azathioprine; systemic
3.9
77.7
238
640
L89
ICD-10 Finland
Decubitus ulcer and pressure area
9.8
76.5
89
93
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
6.0
76.5
138
239
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
74.3
566
2563
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.1
73.2
333
1154
N03AF01
ATC
carbamazepine; oral, rectal
3.9
73.2
226
611
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.3
72.1
299
981
H53.1
ICD-10 Finland
Subjective visual disturbances
3.1
66.8
306
1063
R4110
NOMESCO Finland
Physiotherapy
2.1
66.6
903
5149
RF120, ,
NOMESCO Finland
8.5
66.1
86
104
N02BF01
ATC
gabapentin; oral
2.8
65.6
352
1335
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
+∞
64.8
62
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
12.3
64.3
64
53
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
15.5
63.2
55
36
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.9
62.9
317
1161
A28
ICPC
Limited function/disability NOS
2.6
61.0
394
1640
N05CF01
ATC
zopiclone; oral
1.9
60.9
1005
6107
N04BD01
ATC
selegiline; oral
9.2
59.1
72
80
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
59.0
877
5133
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
+∞
56.4
54
*
R5110, ,
SPAT
3.3
56.2
224
715
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
147.7
55.0
58
*
U04
ICPC
Incontinence urine
3.7
54.6
181
513
CS494
NOMESCO Finland
Other visual field testing
5.2
54.5
115
230
N06AX16
ATC
venlafaxine; oral
2.1
53.3
617
3284
Z43.5
ICD-10 Finland
Attention to cystostomy
18.5
52.6
42
23
A06AD11
ATC
lactulose; oral
2.4
50.3
385
1728
L01BB04
ATC
cladribine; systemic
+∞
50.1
48
*
G81.9
ICD-10 Finland
Hemiplegia, unspecified
7.4
50.0
73
101
G50.0
ICD-10 Finland
Trigeminal neuralgia
5.2
50.0
105
209
N03AF02
ATC
oxcarbazepine; oral
3.8
48.9
156
430
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
485.2
48.5
48
*
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
+∞
48.0
46
*
U07
ICPC
Urine symptom/complaint other
2.8
47.4
255
964
SPAT1216
SPAT
Assessment of functional ability
2.3
46.9
399
1872
H53.4
ICD-10 Finland
Visual field defects
5.4
46.4
92
174
4AA36, ,
NOMESCO Finland
+∞
45.9
44
*
SPAT1167
SPAT
Insertion of urinary catheter
5.5
45.5
89
166
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
12.7
45.2
44
35
L04AX09
ATC
diroximel fumarate; oral
+∞
44.9
43
*
G04CA02
ATC
tamsulosin; oral
2.3
43.9
379
1787
J01XX05
ATC
methenamine; oral
8.5
43.4
56
67
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
5.8
43.2
80
142
U13
ICPC
Bladder symptom/complaint other
3.9
42.7
126
329
J01CA08
ATC
pivmecillinam; oral
1.7
42.4
1472
10838
R39.1
ICD-10 Finland
Other difficulties with micturition
4.4
42.3
109
257
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
41.9
355
1659
N30.0
ICD-10 Finland
Acute cystitis
2.0
41.8
573
3215
6BA02, ,
NOMESCO Finland
15.8
41.8
36
23
3419X
ICD-9 Finland
Other demyelinating diseases of central nervous system, Demyelinating disease of central nervous system, unspecified
+∞
40.7
39
*
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.9
40.1
200
725
G04BD10
ATC
darifenacin; oral
10.9
40.0
43
40
N04BC05
ATC
pramipexole; oral
2.6
39.5
237
946
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
2.8
39.3
206
767
N18
ICPC
Paralysis/weakness
5.5
38.8
76
142
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
38.5
357
1729
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.8
38.4
88
189
359
Kela drug reimbursment
Mirabegroni
13.5
38.3
36
27
N06AA09
ATC
amitriptyline; systemic
2.3
38.2
305
1389
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.1
37.9
162
538
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
7.3
37.7
55
76
R42
ICD-10 Finland
Dizziness and giddiness
1.8
37.5
641
3849
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
70.8
37.0
42
6
U05
ICPC
Urination problems other
3.2
36.6
147
470
RF420, ,
NOMESCO Finland
5.4
36.5
73
139
U28
ICPC
Limited function/disability (U)
8.4
36.0
47
57
R32
ICD-10 Finland
Unspecified urinary incontinence
4.2
35.9
97
237
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.8
35.8
111
300
119
Kela drug reimbursment
Trigeminal neuralgia or glossofaryngeusneuralgia
12.2
35.0
35
29
M03BX02
ATC
tizanidine; oral
1.6
34.7
2068
17042
U08
ICPC
Urinary retention
6.6
34.5
55
84
N30.9
ICD-10 Finland
Cystitis, unspecified
2.5
34.4
219
899
AA1AD
NOMESCO Finland
CT of head and brain
1.8
33.9
642
3963
H02AB07
ATC
prednisone; oral
2.0
33.9
415
2228
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
33.1
346
1752
RF410, ,
NOMESCO Finland
5.5
32.9
64
119
N87
ICPC
Parkinsonism
7.6
32.7
46
61
Z3229
NOMESCO Finland
Other healthcare associate professional
2.4
32.5
247
1098
G04BD01
ATC
emepronium; systemic
8.2
32.5
43
53
N07AA02
ATC
pyridostigmine; systemic
9.2
32.1
39
43
N06AX21
ATC
duloxetine; oral
1.9
31.9
429
2374
Z50.1
ICD-10 Finland
Other physical therapy
2.7
31.2
175
674
R20.1
ICD-10 Finland
Hypoaesthesia of skin
7.3
31.0
45
62
R15
ICD-10 Finland
Faecal incontinence
3.7
30.3
98
273
RS221, ,
NOMESCO Finland
4.6
29.7
70
154
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
29.6
353
1873
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
29.5
381
2078
G37.8
ICD-10 Finland
Other specified demyelinating diseases of central nervous system
+∞
29.2
28
*
G82.2
ICD-10 Finland
Paraplegia, unspecified
8.5
28.8
37
44
U29
ICPC
Urinary symptom/complaint other
3.5
28.5
101
299
N02BF02
ATC
pregabalin; oral
2.4
28.3
212
936
A02BC02
ATC
pantoprazole; systemic
1.5
28.2
1974
16460
34109
ICD-8 Finland
Other demyelinating diseases of central nervous system, Unspecified
+∞
28.2
27
*
G04BE03
ATC
sildenafil; oral
5.7
27.9
52
93
G70.0
ICD-10 Finland
Myasthenia gravis
9.8
27.7
32
33
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
11.2
27.6
29
26
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
9.3
27.4
33
36
Z2446
NOMESCO Finland
Social worker
2.3
26.7
222
1025
G04CA01
ATC
alfuzosin; oral
2.3
26.5
209
944
R20.0
ICD-10 Finland
Anaesthesia of skin
5.7
26.0
48
85
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
25.9
587
3778
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
25.9
690
4630
N06AB04
ATC
citalopram; systemic
1.6
25.2
649
4315
J01XE01
ATC
nitrofurantoin; oral
3.8
24.9
77
208
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
24.7
1093
8205
G04BE01
ATC
alprostadil; parenteral, urethral
6.3
24.4
41
66
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.7
24.2
78
217
RS222, ,
NOMESCO Finland
5.0
24.2
52
106
H57.1
ICD-10 Finland
Ocular pain
2.5
24.1
153
626
Z93.5
ICD-10 Finland
Cystostomy status
33.6
23.3
30
9
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.0
23.2
277
1467
R03CA02
ATC
ephedrine; oral
28.4
23.1
31
11
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.7
23.1
72
196
F02.89
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere without information of additional symptoms
54.4
23.1
27
5
WW400
NOMESCO Finland
Plasmaferesis
30.3
22.8
30
10
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
5.6
22.7
43
78
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.8
22.5
116
428
XCK10
NOMESCO Finland
Photography of fundus of eye
2.1
22.5
223
1104
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.0
22.2
99
337
ZXY02
NOMESCO Finland
Neuropsychologist
6.1
22.0
38
63
G20
ICD-10 Finland
Parkinson disease
3.9
21.7
63
163
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
4.1
21.6
59
146
H30.2
ICD-10 Finland
Posterior cyclitis
8.8
21.5
27
31
J01MA02
ATC
ciprofloxacin; systemic
1.5
21.4
1006
7594
K59.09
ICD-10 Finland
Constipation, unspecified
2.3
21.3
165
739
RS121, ,
NOMESCO Finland
6.2
21.1
36
59
H53.9
ICD-10 Finland
Visual disturbance, unspecified
2.6
20.9
121
474
H48.1
ICD-10 Finland
Retrobulbar neuritis in diseases classified elsewhere
+∞
20.9
20
*
SPAT1293
SPAT
Other function in accordance with rehabilitation guidance nomenclature
7.1
20.8
31
44
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
20.6
284
1576
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
3.5
20.6
70
202
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
20.3
743
5321
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
5.1
20.2
42
83
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
20.2
770
5561
G51.0
ICD-10 Finland
Bell palsy
3.0
20.1
92
318
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.1
19.7
203
1018
ABD40
NOMESCO Finland
Implantation of spinal injection device
74.0
19.7
22
*
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.5
19.5
66
190
G04BDXX, ,
ATC
21.7
19.5
28
13
U02
ICPC
Urinary frequency/urgency
1.7
19.5
404
2527
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
19.4
1050
8109
Z2221
NOMESCO Finland
Medical doctor
1.5
19.2
828
6121
G61.0
ICD-10 Finland
Guillain-Barré syndrome
8.1
18.8
25
31
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
5.3
18.7
37
70
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
4.9
18.5
40
82
H04.10
ICD-10 Finland
Dry eye syndrome
1.7
18.0
339
2063
SPAT1262
SPAT
Handing over of treatment supplies
1.7
17.9
397
2525
N07AA03
ATC
distigmine; systemic
20.2
17.7
26
13
RF432, ,
NOMESCO Finland
95.6
17.6
19
*
36702
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica. Papillitis
181.0
17.5
18
*
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.2
17.3
142
653
R47.1
ICD-10 Finland
Dysarthria and anarthria
5.2
17.2
35
68
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
3.2
17.1
68
217
RS340, ,
NOMESCO Finland
14.9
17.1
28
19
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
17.1
627
4472
S97
ICPC
Chronic ulcer skin
2.3
17.0
126
554
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.7
17.0
329
2016
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
5.2
16.7
34
66
N06
ICPC
Sensation disturbance other
4.0
16.7
47
119
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
3.8
16.5
49
129
7819X
ICD-9 Finland
Symptoms involving nervous and musculoskeletal systems, Other symptoms involving nervous and musculoskeletal systems[SYMPTOMATA ALIA SYSTEMATIS NERVORUM ET MUSCULOSCEL]
5.1
16.5
34
67
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
16.4
268
1565
J01MA06
ATC
norfloxacin; oral
1.6
16.4
364
2312
SPAT1325
SPAT
Vaccination
1.4
16.3
766
5728
R60.0
ICD-10 Finland
Localized oedema
1.8
16.2
274
1618
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
6.0
16.0
28
47
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
47.7
16.0
19
*
Z73.6
ICD-10 Finland
Limitation of activities due to disability
5.4
15.9
31
58
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.1
15.6
65
214
U71
ICPC
Cystitis/urinary infection other
1.9
15.6
197
1063
3773A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[PAPILLITIS OPTICA]
160.8
15.5
16
*
N03AX09
ATC
lamotrigine; oral
1.9
15.4
187
994
J05AB11
ATC
valaciclovir; oral
1.6
15.4
416
2769
K59.0
ICD-10 Finland
Constipation
2.1
15.2
139
668
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.1
15.1
137
656
M05BA04
ATC
alendronic acid; oral
2.0
15.0
160
813
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
2.3
14.9
115
516
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
14.8
330
2098
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.8
14.7
216
1221
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.0
14.7
65
221
R13
ICD-10 Finland
Dysphagia
2.0
14.7
172
904
G04BD
ATC
Drugs for urinary frequency and incontinence
18.5
14.7
22
12
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
6.0
14.3
25
42
R27.0
ICD-10 Finland
Ataxia, unspecified
13.4
14.2
24
18
RF122, ,
NOMESCO Finland
17.6
13.8
21
12
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
13.8
261
1588
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.7
13.7
74
281
G37.0
ICD-10 Finland
Diffuse sclerosis
+∞
13.5
13
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.1
13.4
135
672
H52.1
ICD-10 Finland
Myopia
2.1
13.4
135
673
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.4
13.3
93
399
J01MA12
ATC
levofloxacin; systemic
1.5
13.2
413
2839
N06AX11
ATC
mirtazapine; oral
1.4
13.1
945
7552
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
12.2
13.1
23
19
R31
ICD-10 Finland
Unspecified haematuria
1.9
12.9
175
967
KCE02
NOMESCO Finland
Transluminal endoscopic extraction of calculus from bladder
9.7
12.7
25
26
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.8
12.7
176
979
OAB43, ,
SPAT
0.7
12.6
776
9750
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
2.9
12.6
57
197
G36.8
ICD-10 Finland
Other specified acute disseminated demyelination
+∞
12.5
12
*
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
2.2
12.4
103
476
1DB07, ,
NOMESCO Finland
130.5
12.4
13
*
N02BE01
ATC
paracetamol; systemic, rectal
1.4
12.3
2629
24535
OAB50, ,
SPAT
2.0
12.3
131
667
N39.9
ICD-10 Finland
Disorder of urinary system, unspecified
3.1
12.3
51
168
R5130, ,
SPAT
15.9
12.1
19
12
R51.80
ICD-10 Finland
Headache
1.4
12.1
498
3614
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.0
12.0
133
686
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
3.5
11.8
40
116
C03CA01
ATC
furosemide; systemic
1.5
11.5
437
3118
XA402
NOMESCO Finland
ENMG
2.4
11.5
74
307
108
Kela drug reimbursment
Myasthenia gravis
10.1
11.5
22
22
G04.8
ICD-10 Finland
Other encephalitis, myelitis and encephalomyelitis
+∞
11.5
11
*
R5599
NOMESCO Finland
Other rehabilitation service
2.4
11.4
77
327
R4110, ,
SPAT
1.7
11.2
208
1259
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.0
11.2
123
634
J05AB01
ATC
aciclovir; systemic
1.4
11.0
614
4689
G83.1
ICD-10 Finland
Monoplegia of lower limb
11.2
11.0
20
18
SPAT1234
SPAT
Support of social functional capacity
2.1
11.0
107
527
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
11.0
217
1335
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
5.7
11.0
20
35
T83.0
ICD-10 Finland
Mechanical complication of urinary (indwelling) catheter
43.5
10.9
13
*
SPAT1263
SPAT
Sampling
1.3
10.9
1137
9525
SPAT1254
SPAT
Administration of medicine
1.5
10.9
313
2110
RS130, ,
NOMESCO Finland
8.9
10.7
22
25
KCW98
NOMESCO Finland
Other transluminal endoscopic operation on bladder
28.1
10.7
14
5
AAH30
NOMESCO Finland
Thermal destruction of cranial nerve
28.1
10.7
14
5
U01
ICPC
Dysuria/painful urination
1.7
10.7
217
1346
183
Kela drug reimbursment
Lamotrigin and topiramate
3.6
10.6
34
95
F05
ICPC
Visual disturbance other
2.3
10.6
76
331
N21.0
ICD-10 Finland
Calculus in bladder
5.3
10.6
21
40
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
2.7
10.5
55
206
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
10.5
890
7239
RF210, ,
NOMESCO Finland
2.2
10.5
86
397
A02BA02
ATC
ranitidine; systemic
1.5
10.5
414
2976
34108
ICD-8 Finland
Other demyelinating diseases of central nervous system, Alii definiti
+∞
10.4
10
*
R4130
NOMESCO Finland
Speech therapy
2.5
10.3
62
249
SPAT1301
SPAT
No procedures
1.3
10.3
736
5837
SPAT1172
SPAT
Guidance concerning hydration
3.2
10.3
39
122
N07AB01
ATC
carbachol; systemic
10.6
10.3
19
18
NA1BM
NOMESCO Finland
Cervical spine MRI examination with 3 Tesla magnet
9.6
10.2
20
21
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.8
10.2
149
842
N06AB10
ATC
escitalopram; oral
1.4
10.2
665
5201
J01MA01
ATC
ofloxacin; systemic
1.7
10.2
179
1069
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.6
10.1
274
1822
ZXA10
NOMESCO Finland
Bilateral
1.4
10.1
403
2903
N05BA01
ATC
diazepam; systemic, rectal
1.5
10.0
320
2203
M05BX04
ATC
denosumab; parenteral
2.0
10.0
105
532
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.5
10.0
380
2709
RF310, ,
NOMESCO Finland
9.1
10.0
20
22
G96.9
ICD-10 Finland
Disorder of central nervous system, unspecified
14.6
10.0
16
11
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
3.3
10.0
36
109
H20.1
ICD-10 Finland
Chronic iridocyclitis
3.3
10.0
36
109
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
2.5
9.9
63
260
TKC10, ,
SPAT
26.1
9.8
13
5
N04BC04
ATC
ropinirole; oral
4.4
9.8
24
55
XKW99
NOMESCO Finland
Other physiological examination of urinary or male genital system
4.5
9.8
23
51
SPAT1260
SPAT
Consultation of another employee
1.4
9.8
421
3073
N03AX14
ATC
levetiracetam; systemic
2.3
9.7
71
312
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.5
9.6
281
1898
H50.52
ICD-10 Finland
Exophoria
2.8
9.6
46
165
ZY010
NOMESCO Finland
Hospital outpatient
1.7
9.6
168
1003
G61.9
ICD-10 Finland
Inflammatory polyneuropathy, unspecified
11.4
9.5
17
15
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
2.6
9.5
55
217
R30.1
ICD-10 Finland
Vesical tenesmus
2.6
9.5
55
217
RS230, ,
NOMESCO Finland
4.8
9.5
21
44
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
2.9
9.4
43
150
SPAT1171
SPAT
Bladder puncture
30.1
9.4
12
*
RF312, ,
NOMESCO Finland
17.6
9.4
14
8
N02AX02
ATC
tramadol; systemic, rectal
1.3
9.4
1047
8807
34400
ICD-8 Finland
Other cerebral paralysis, Hemiplegia NUD
21.7
9.3
13
6
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
9.5
9.3
18
19
A29
ICPC
General symptom/complaint other
1.5
9.2
279
1899
F43.21
ICD-10 Finland
Adaptation disorder with prolonged depression
3.0
8.9
38
128
R26.0
ICD-10 Finland
Ataxic gait
12.6
8.9
15
12
G61.8
ICD-10 Finland
Other inflammatory polyneuropathies
12.6
8.9
15
12
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.5
8.8
304
2125
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.4
8.8
402
2961
K59.01
ICD-10 Finland
Constipation outlet obstruction type
2.9
8.8
39
134
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
4.0
8.8
24
60
N86
ICD-10 Finland
Erosion and ectropion of cervix uteri
4.8
8.6
19
40
A46
ICD-10 Finland
Erysipelas
1.5
8.6
268
1838
XA412
NOMESCO Finland
VEP
16.3
8.5
13
8
J01DB01
ATC
cefalexin; oral
1.3
8.5
2464
23105
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
2.2
8.5
66
299
N06AX12
ATC
bupropion; oral
1.5
8.5
246
1661
SPAT1281
SPAT
Other administrative function
1.6
8.5
192
1226
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
3.7
8.4
26
71
N05CD07
ATC
temazepam; oral
1.6
8.4
200
1290
L95
ICPC
Osteoporosis
2.3
8.4
64
287
R2110
NOMESCO Finland
Giving the first information
1.6
8.4
206
1340
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
2.8
8.4
41
149
H02AB06
ATC
prednisolone; systemic
1.3
8.4
1232
10672
4AA34, ,
NOMESCO Finland
+∞
8.3
8
*
H81.4
ICD-10 Finland
Vertigo of central origin
4.0
8.3
23
58
XX1XW
NOMESCO Finland
Extensive written report from radiologist
2.3
8.3
58
251
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
8.3
191
2895
RF220, ,
NOMESCO Finland
3.1
8.3
34
112
NA1DG
NOMESCO Finland
Cervical spine very extensive MRI examination with high intensity magnet
7.1
8.2
19
27
A07AA09
ATC
vancomycin; oral
3.2
8.2
31
97
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
2.7
8.2
41
151
S72.4
ICD-10 Finland
Fracture of lower end of femur
4.4
8.1
20
46
OAA80, ,
SPAT
0.6
8.1
118
2001
D12
ICPC
Constipation
2.1
8.1
74
358
R1250, ,
SPAT
2.6
8.1
45
175
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.6
8.1
179
1137
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.3
8.0
56
242
F43.29
ICD-10 Finland
Adaptation disorder UNS
2.0
8.0
86
441
K07
ICPC
Swollen ankles/oedema
2.1
8.0
76
373
W19
ICD-10 Finland
Unspecified fall
1.5
8.0
213
1412
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
8.0
159
983
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
2.5
8.0
48
194
G04AA01, ,
ATC
3.9
8.0
23
60
N27
ICPC
Fear of neurological disease other
2.9
8.0
35
120
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
3.2
7.9
31
99
SPAT1050
SPAT
Extensive neurological examination
2.4
7.9
51
213
SPAT1255
SPAT
Intravenous administration of medicine
1.7
7.9
144
870
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
7.9
451
3447
XKX00
NOMESCO Finland
Pelvic floor electromyography
6.6
7.9
19
29
WX320
NOMESCO Finland
Spinalanesthesy
0.7
7.9
326
4413
WX892
NOMESCO Finland
Monitored bed care
1.7
7.8
148
904
L04AB04
ATC
adalimumab; parenteral
0.2
7.8
7
364
G04AC01, ,
ATC
2.0
7.8
78
391
U72
ICPC
Urethritis
2.1
7.7
66
311
R83.4
ICD-10 Finland
Abnormal findings in cerebrospinal fluid, Abnormal immunological findings
45.1
7.7
9
*
A02BA04
ATC
nizatidine; systemic
1.7
7.7
141
854
M48.0
ICD-10 Finland
Spinal stenosis
1.6
7.7
198
1304
A06AC51
ATC
ispaghula, combinations; oral
1.8
7.7
112
636
SPAT1125
SPAT
Stoma care and guidance
3.4
7.6
27
81
R50.9
ICD-10 Finland
Fever, unspecified
1.4
7.6
356
2631
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
2.4
7.6
50
211
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
11.9
7.6
13
11
H51.8
ICD-10 Finland
Other specified disorders of binocular movement
25.1
7.6
10
*
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
1.9
7.6
90
479
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.0
7.6
79
402
R53
ICD-10 Finland
Malaise and fatigue
1.3
7.5
638
5157
ABD32
NOMESCO Finland
Implantation of temporary spinal stimulation device
3.8
7.5
22
58
D17
ICPC
Incontinence of bowel
3.8
7.5
22
58
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
1.9
7.4
85
446
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.4
7.4
300
2162
N30.8
ICD-10 Finland
Other cystitis
3.1
7.4
30
98
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
3.5
7.4
24
68
N02AA05
ATC
oxycodone; systemic
1.4
7.4
293
2105
N30
ICD-10 Finland
Cystitis
1.5
7.4
233
1602
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
4.0
7.3
20
50
S06.0
ICD-10 Finland
Concussion
1.5
7.3
261
1837
H01AA02
ATC
tetracosactide; parenteral
+∞
7.3
7
*
G37.1
ICD-10 Finland
Central demyelination of corpus callosum
+∞
7.3
7
*
3418X
ICD-9 Finland
Other demyelinating diseases of central nervous system
+∞
7.3
7
*
RS142, ,
NOMESCO Finland
6.8
7.3
17
25
SPAT1312
SPAT
General health counselling
1.3
7.3
819
6856
SPAT1211
SPAT
Application of soft bandage
1.6
7.2
185
1216
G11.9
ICD-10 Finland
Hereditary ataxia, unspecified
15.8
7.2
11
7
NA7DM
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with 3 Tesla magnet
15.8
7.2
11
7
RF311, ,
NOMESCO Finland
15.8
7.2
11
7
3AX01, ,
NOMESCO Finland
5.8
7.2
19
33
A04
ICPC
Weakness/tiredness general
1.4
7.2
359
2683
A08
ICPC
Swelling
1.8
7.2
95
524
R30.0
ICD-10 Finland
Dysuria
1.7
7.1
115
672
Z74.0
ICD-10 Finland
Need for assistance due to reduced mobility
30.1
7.1
9
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
7.1
742
6149
R1260
NOMESCO Finland
Evaluation of communicative skills
2.8
7.1
35
128
KH1EE
NOMESCO Finland
Urologic ultrasound examination
7.9
7.1
15
19
RF433, ,
NOMESCO Finland
12.0
7.1
12
10
Z01.2
ICD-10 Finland
Dental examination
1.2
7.0
1326
11733
D21
ICPC
Swallowing problem
2.7
7.0
36
135
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
3.9
7.0
20
52
R4120, ,
SPAT
3.4
7.0
24
71
R20
ICD-10 Finland
Disturbances of skin sensation
4.4
7.0
17
39
M05BB03
ATC
alendronic acid and colecalciferol; oral
2.6
6.9
39
153
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
1.8
6.9
103
589
78050
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Vertigo
3.7
6.9
21
57
KDV20
NOMESCO Finland
Submucous urethral injection
13.8
6.9
11
8
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.6
6.9
156
998
XF600
NOMESCO Finland
Bloodpressure measurement
1.7
6.8
129
788
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.7
6.8
35
131
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
10.9
6.8
12
11
G83.9
ICD-10 Finland
Paralytic syndrome, unspecified
9.3
6.8
13
14
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
2.4
6.8
43
179
78161
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Paraesthesia
40.1
6.8
8
*
WVA20
NOMESCO Finland
Medicine administration
2.1
6.7
61
295
Z46.6
ICD-10 Finland
Fitting and adjustment of urinary device
22.6
6.7
9
*
XX9CW
NOMESCO Finland
Submitting image material and/or investigation material to patient
3.0
6.6
28
94
SPAT1127
SPAT
Enema
5.9
6.6
17
29
TNX34
NOMESCO Finland
Major custom molded cast, unspecified region
2.5
6.6
38
151
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
6.6
427
3323
H54.7
ICD-10 Finland
Unspecified visual loss
3.8
6.5
19
50
R1420, ,
SPAT
10.0
6.5
12
12
34999
ICD-8 Finland
Other diseases of spinal cord, Other and unspecified
70.0
6.4
7
*
N19
ICPC
Speech disorder
3.2
6.4
24
75
WZC00
NOMESCO Finland
Treatment plan or consultation
1.2
6.4
940
8086
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
2.9
6.4
29
102
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
2.1
6.3
55
262
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
2.9
6.3
28
97
ZXE22
NOMESCO Finland
Procedure duration at least 4 but less than 5 hours
6.0
6.3
16
27
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
5.5
6.3
17
31
G04BE08
ATC
tadalafil; oral
9.3
6.3
12
13
N06AX18
ATC
reboxetine; oral
2.5
6.3
36
143
G04BE09
ATC
vardenafil; oral
18.0
6.3
9
5
QBG10
NOMESCO Finland
Excision and repair of bedsore of trunk
18.0
6.3
9
5
R25.2
ICD-10 Finland
Cramp and spasm
2.1
6.3
56
270
G04.0
ICD-10 Finland
Acute disseminated encephalitis
+∞
6.3
6
*
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
4.0
6.2
17
43
R52.2
ICD-10 Finland
Other chronic pain
1.7
6.1
95
550
L19
ICPC
Muscle symptom/complaint NOS
1.9
6.1
74
397
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
4.1
6.1
16
39
R11
ICD-10 Finland
Nausea and vomiting
1.5
6.1
205
1430
A41.9
ICD-10 Finland
Sepsis, unspecified
2.0
6.1
58
287
TKD00
NOMESCO Finland
Dilatation of urethra
3.1
6.0
24
78
RF214, ,
NOMESCO Finland
10.0
6.0
11
11
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
2.5
6.0
35
140
J05AH02
ATC
oseltamivir; oral
3.2
6.0
23
73
ZX198
NOMESCO Finland
Other local administration
3.2
6.0
23
73
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
5.2
6.0
17
33
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
2449
13219
4.84
323.01
13.3
6.0
0.19
0.19
e9/l
0.07
2291
11816
2305
11974
4.46
318.91
13.1
6.1
9.10
8.16
%
49.37
2268
11292
2294
11889
4.43
318.12
12.9
5.8
3.02
2.80
%
4.93
2258
11184
2433
13191
4.72
315.67
13.3
5.7
1.67
1.98
e9/l
10.79
2285
11881
2427
12727
4.96
307.65
13.3
5.7
0.55
0.54
e9/l
0.42
2265
11187
349
137
28.53
307.65
4.1
2.1
0.26
0.21
e9/l
2.07
306
115
606
192
38.85
307.65
1.1
1.1
213.80
226.94
mg/l
0.68
528
165
525
236
26.50
307.65
1.0
1.0
—
—
—
0
0
703
1460
5.91
307.65
3.5
1.7
1.02
1.40
g/l
7.40
691
1353
1077
1863
8.27
307.65
3.5
2.6
9.96
10.60
g/l
6.25
987
1722
617
202
37.75
307.65
1.1
1.2
56.01
32.98
mg/l
12.62
502
171
682
600
14.23
307.65
1.1
1.3
421.95
475.50
mg/l
1.91
656
569
347
26
149.88
307.65
1.2
1.1
—
—
—
0
0
405
147
31.47
307.65
1.0
1.1
0.95
1.03
u/l
1.70
143
68
195
15
138.52
307.65
1.1
1.0
—
—
—
0
0
546
542
11.98
307.65
1.1
1.3
3.54
3.68
mmol/l
2.02
508
509
615
188
40.42
307.65
1.1
1.1
—
—
—
0
0
2398
11951
5.23
307.65
13.5
6.1
—
—
—
0
0
2426
12746
4.94
307.65
13.3
5.7
0.04
0.04
e9/l
0.41
2266
11183
570
536
12.77
307.65
1.2
1.5
520.65
1639.92
e6/l
1.02
457
433
470
8
687.14
307.65
2.9
1.1
—
—
—
0
0
615
830
8.97
307.65
1.8
1.5
62.87
0.19
iu/ml
0.59
39
165
570
537
12.74
307.65
1.1
1.4
34.95
22.77
e6/l
0.21
445
412
260
132
21.38
307.65
1.1
1.1
1710.84
1510.17
miu/ml
1.05
260
132
351
141
27.89
307.65
4.1
2.1
473.63
630.14
e6/l
1.39
304
115
706
417
21.54
307.65
1.2
1.1
—
—
—
0
0
2269
11474
4.50
307.65
12.9
5.9
0.76
0.68
%
11.82
2231
10752
258
161
17.37
307.25
2.9
2.0
—
—
—
0
0
192
62
32.91
297.22
3.0
1.7
51.40
175.14
e6/l
3.53
86
35
2317
12440
4.27
296.66
12.9
5.8
26.41
29.31
%
35.16
2281
11761
183
53
36.60
292.40
4.8
2.6
—
—
—
0
0
2291
12287
4.18
291.74
12.6
5.6
58.83
56.46
%
20.85
2254
11605
708
1771
4.87
267.03
1.3
1.3
37.13
45.92
au/ml
0.24
12
98
740
1924
4.72
265.91
2.5
2.4
31.37
22.34
au/ml
0.81
29
198
2481
14606
4.30
262.66
14.0
8.7
3.68
4.00
e9/l
14.13
2319
12864
1444
6677
3.15
211.82
4.9
2.9
20.89
95.94
e6/l
2.56
1233
5004
1929
10525
3.15
210.55
2.5
2.2
91.70
74.48
nmol/l
82.36
1823
9745
1132
4612
3.27
205.20
3.6
2.4
4.69
7.31
e6/l
10.96
1059
4115
205
174
12.53
204.26
1.1
1.4
1.67
1.89
mmol/l
4.30
190
162
1342
6077
3.11
202.15
4.6
2.8
0.15
0.35
e6/l
8.71
1135
4501
1575
8198
2.84
177.87
5.9
3.3
81.30
77.81
e6/l
0.07
1276
5505
2461
16495
3.26
168.06
8.6
3.8
2855.29
1662.02
e6/l
0.29
35
190
1881
11316
2.65
150.64
13.7
8.3
0.00
0.00
e9/l
0.26
1633
9262
137
117
12.20
135.52
1.1
1.4
94.76
61.31
%
2.73
21
13
823
3622
2.72
120.20
4.2
2.4
0.93
1.23
e6/l
1.06
502
1949
133
137
10.09
115.76
3.9
2.7
50.31
44.01
%
2.59
102
71
1910
12662
2.29
107.93
6.2
3.2
0.00
0.00
estimate
1.32
461
2328
97
68
14.69
107.72
1.1
1.2
3.58
24.33
%
—
19
6
1895
12540
2.28
107.28
6.2
3.2
0.00
0.00
estimate
0.22
469
2490
1897
12567
2.28
106.99
8.2
4.4
0.00
0.00
estimate
0.37
461
2405
490
1789
3.06
99.79
5.6
4.1
0.24
0.64
%
6.71
126
523
359
1093
3.58
98.32
1.4
2.1
36.21
39.79
u/l
2.98
337
999
741
3385
2.56
97.96
4.4
2.6
5.26
3.63
e6/l
1.84
419
1719
493
1872
2.94
93.24
5.9
4.4
0.04
0.11
%
1.52
119
517
1493
9386
2.12
90.69
3.7
4.6
37.48
36.51
g/l
9.69
1402
8782
75
68
11.27
71.14
2.0
2.1
—
—
—
0
0
1706
12048
1.91
67.00
5.0
5.8
9.72
10.52
umol/l
3.61
1638
11414
188
479
4.11
65.98
4.3
3.9
60.12
56.97
%
2.92
188
479
83
106
8.02
60.96
1.1
1.8
—
—
—
0
0
605
3166
2.13
54.84
1.8
2.1
29.28
29.43
s
0.36
584
3063
333
1367
2.61
52.76
2.7
1.8
—
—
—
0
0
935
5767
1.88
52.71
2.4
1.4
2.01
2.24
g/l
5.91
705
3712
68
87
7.97
49.85
1.1
1.1
36.68
394.69
ng/l
0.81
25
13
324
1399
2.47
45.94
1.5
2.5
68.39
67.32
g/l
1.97
308
1295
270
1076
2.65
45.22
1.4
1.4
—
—
—
0
0
405
1971
2.21
43.43
2.6
2.2
2601.47
5325.84
u/l
1.05
101
806
1753
13524
1.67
41.95
4.1
4.3
6.18
6.46
mmol/l
9.41
1655
12431
959
6347
1.73
40.72
2.2
2.0
135.26
203.91
u/l
2.16
914
6029
2244
18595
1.72
39.82
6.4
7.0
73.32
74.38
u/l
0.64
2121
17623
68
115
6.02
38.56
1.0
1.1
—
—
—
0
0
1348
9887
1.64
38.04
7.0
3.2
—
—
—
0
0
972
6605
1.68
36.68
7.6
3.5
0.00
0.00
estimate
1.49
458
2363
39
39
10.11
34.50
1.0
1.3
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
65
120
5.51
33.65
1.0
1.1
—
—
—
0
0
86
208
4.22
32.31
1.2
1.6
—
—
—
0
0
234
1040
2.35
30.82
5.0
2.6
0.25
0.25
e6/l
0.03
228
997
3007
28016
2.65
29.45
15.7
9.0
26.71
26.15
u/l
0.93
2948
27230
2880
26389
2.08
28.94
14.6
11.3
20.59
20.31
mg/l
0.16
2228
20487
44
66
6.75
28.04
1.0
1.1
—
—
—
0
0
2219
19023
1.56
27.59
4.4
2.9
42.22
39.98
u/l
0.59
2137
18121
2615
23439
1.68
25.79
21.2
13.4
14.18
14.62
%
1.38
2589
23028
42
66
6.44
25.62
1.0
1.1
—
—
—
0
0
42
66
6.44
25.62
1.0
1.1
—
—
—
0
0
2824
25886
1.89
25.57
13.7
11.7
139.71
139.64
mmol/l
0.95
2770
25215
2974
27782
2.28
25.26
16.1
12.2
67.10
71.07
umol/l
18.71
2974
27775
78
211
3.77
25.18
1.2
1.7
—
—
—
0
0
2830
25982
1.89
25.16
13.7
11.8
3.91
3.93
mmol/l
3.27
2769
25257
2348
25881
0.63
25.04
3.6
3.7
1.50
1.49
mmol/l
0.04
2161
24521
1155
8770
1.50
24.73
3.7
3.1
29.60
30.91
u/l
0.58
1118
8367
46
83
5.61
24.44
1.0
1.0
—
—
—
0
0
1197
9176
1.49
24.36
8.0
9.8
1.08
1.14
inr
4.00
387
2867
2404
26262
0.64
22.75
3.9
4.1
2.89
2.89
mmol/l
0.09
2208
24825
27
29
9.38
22.64
1.1
1.1
91.39
41.00
%
3.35
18
12
2252
24920
0.66
22.40
3.3
3.4
1.25
1.27
mmol/l
0.51
2078
23500
38
62
6.19
22.37
1.0
1.1
—
—
—
0
0
39
66
5.97
22.14
1.0
1.1
—
—
—
0
0
2376
25991
0.65
22.09
3.6
3.8
4.80
4.81
mmol/l
0.27
2204
24710
1341
10697
1.44
21.36
5.4
6.1
1.22
1.22
mmol/l
4.02
1112
9160
483
3131
1.64
20.32
1.9
1.8
—
—
—
0
0
817
5970
1.50
20.24
3.4
3.6
97.22
95.74
%
1.17
804
5803
1111
8648
1.44
19.77
1.8
1.8
95.74
97.99
pmol/l
0.80
564
4626
2665
24514
1.57
17.93
12.9
9.8
94.49
89.18
ml/min/173m2
37.27
2283
20197
36
73
4.98
16.87
1.1
1.1
—
—
—
0
0
1182
9602
1.37
15.33
4.9
5.4
1.22
1.21
mmol/l
2.44
1073
8847
91
362
2.56
15.31
1.3
1.8
—
1366.67
—
0
12
2116
18906
1.36
14.30
3.4
3.8
9.97
10.09
mm/h
0.18
1978
17733
22
33
6.71
14.02
1.0
1.0
—
—
—
0
0
321
2095
1.59
12.87
1.7
1.7
—
—
—
0
0
616
4634
1.41
12.24
1.6
1.5
19.99
20.84
nmol/l
0.43
535
4086
702
5407
1.38
12.11
6.8
3.5
1.02
1.02
kg/l
0.41
103
784
319
2127
1.56
11.64
1.7
1.7
—
—
—
0
0
2629
24612
1.41
11.41
5.3
4.8
1.70
2.03
mu/l
2.01
2460
23186
141
764
1.89
11.05
1.5
1.6
76.11
254.48
titre
—
9
29
475
3477
1.43
10.90
1.7
1.7
1050.19
1193.45
nmol/l
2.35
360
2698
51
180
2.86
10.90
2.9
2.9
48.93
53.74
%
0.80
46
162
175
1038
1.73
10.18
1.6
1.6
—
—
—
0
0
55
212
2.62
9.98
1.1
1.2
—
—
—
0
0
136
755
1.84
9.91
2.1
1.8
—
—
—
0
0
955
7902
1.30
9.80
3.2
2.9
35.83
42.16
ng/l
0.23
545
4211
28
74
3.81
9.49
3.3
2.6
23.67
29.95
umol/l
1.44
19
57
193
1199
1.65
9.46
1.2
1.3
2.66
0.93
u/ml
—
9
106
22
32
6.91
9.30
1.0
1.0
—
—
—
0
0
127
709
1.82
9.11
1.6
2.1
9.22
10.87
mg/l
1.98
122
666
112
610
1.87
8.71
1.6
2.1
2.63
2.94
g/l
2.66
107
562
116
641
1.84
8.62
1.6
2.0
—
—
—
0
0
116
641
1.84
8.62
1.6
2.0
6.85
7.29
g/l
2.47
111
593
81
398
2.06
8.48
1.3
1.3
—
—
—
0
0
81
398
2.06
8.48
1.3
1.3
—
—
—
0
0
20
30
6.70
8.35
1.0
1.2
—
—
—
0
0
115
641
1.82
8.32
1.6
2.0
3.27
3.60
g/l
2.82
110
593
106
586
1.84
7.89
1.7
2.1
9.09
10.37
g/l
3.78
101
537
230
3310
0.67
7.76
1.5
1.6
—
—
—
0
0
206
1379
1.53
7.40
1.2
1.3
193.44
223.04
miu/ml
0.56
75
708
37
137
2.72
7.34
1.6
2.8
702.03
901.18
u/ml
0.30
37
137
20
50
4.02
7.34
1.0
1.1
—
—
—
0
0
137
840
1.66
7.13
2.2
1.9
—
—
—
0
0
16
23
6.99
6.99
1.0
1.2
—
—
—
0
0
889
7544
1.25
6.95
2.5
3.2
2.35
2.35
mmol/l
0.13
774
6828
16
24
6.69
6.80
1.0
1.1
—
—
—
0
0
27
88
3.09
6.73
1.0
1.1
—
—
—
0
0
142
909
1.59
6.26
1.7
1.9
—
—
—
0
0
122
753
1.65
6.24
1.3
1.3
112.35
124.86
titre
0.09
17
74
571
4660
1.28
6.14
1.5
1.6
452.08
37130491.37
pmol/l
4.19
488
4021
88
500
1.78
6.08
1.7
2.1
0.00
0.01
g/l
0.65
83
469
3048
29844
1.68
6.07
26.6
16.6
40.63
40.50
%
0.32
2890
28411
363
2793
1.34
6.04
2.2
2.6
5.97
7.12
umol/l
0.75
316
2390
273
2009
1.39
6.02
3.4
2.6
1.57
1.77
%
3.85
234
1792
132
841
1.59
5.95
1.1
1.2
—
—
—
0
0
94
551
1.73
5.84
1.7
2.2
0.39
0.74
g/l
0.90
88
498
88
507
1.76
5.81
1.6
2.0
40.06
38.58
g/l
1.42
83
459
82
463
1.79
5.80
1.7
2.1
0.00
0.00
g/l
-0.00
77
433
40
174
2.32
5.76
1.0
1.1
4.38
5.85
nmol/l
—
10
28
3048
29875
1.64
5.63
26.6
16.6
263.39
261.74
e9/l
0.78
3015
29293
3050
29901
1.65
5.61
26.6
16.6
6.44
6.67
e9/l
5.30
3011
29259
3049
29902
1.63
5.43
26.6
16.6
4.52
4.53
e12/l
0.36
3011
29267
15
29
5.19
5.38
1.0
1.2
—
—
—
0
0
16
43
3.73
5.36
1.1
1.1
—
—
—
0
0
3049
29911
1.62
5.30
26.7
16.6
135.95
135.74
g/l
0.44
3031
29597
12
18
6.69
5.25
1.0
1.1
—
—
—
0
0
5
0
+∞
5.21
1.0
0.0
—
—
—
0
0
2161
22799
0.83
5.14
4.4
4.6
37.51
38.30
mmol/mol
3.91
2000
21536
133
883
1.53
5.06
1.7
1.8
1.17
1.18
g/l
0.16
128
826
129
855
1.53
4.95
1.7
1.9
0.24
0.23
g/l
0.70
124
800
37
168
2.22
4.87
1.2
1.1
1.80
34.92
u/ml
—
5
13
855
7456
1.20
4.83
2.3
2.5
51.76
57.66
u/l
4.88
789
6948
11
17
6.49
4.77
1.0
1.1
—
—
—
0
0
194
1407
1.40
4.71
2.4
2.7
62.23
73.52
e9/l
4.70
143
1044
555
6561
0.81
4.63
3.6
3.2
8.00
7.79
mmol/l
0.49
481
5706
16
48
3.35
4.60
1.0
1.1
—
—
—
0
0
230
1725
1.36
4.56
3.9
3.4
1.23
1.23
mmol/l
0.36
194
1492
277
2138
1.32
4.54
2.6
4.3
225.49
239.86
u/l
1.00
262
2031
19
66
2.89
4.33
1.2
1.4
100.85
115.45
nmol/l
0.19
13
50
55
955
0.57
4.26
1.3
1.5
—
—
—
0
0
470
5608
0.81
4.26
3.8
3.3
912.07
327.52
mg/l
0.98
305
3562
465
3870
1.24
4.16
2.9
3.1
335.19
491.93
ng/l
0.46
261
2433
496
5870
0.82
4.14
4.3
3.8
5.43
9.57
mg/mmol
3.10
313
3740
11
21
5.25
4.14
1.5
1.5
1.62
0.81
mg/l
—
6
14
19
68
2.81
4.12
1.2
1.1
89.58
96.49
%
0.35
19
68
123
843
1.48
4.08
3.3
3.3
26.03
25.24
mmol/l
2.15
115
813
70
1127
0.61
4.05
1.4
1.8
—
—
—
0
0
108
724
1.51
4.00
4.1
6.2
1.86
1.67
%
0.74
101
673
87
1327
0.65
3.98
1.6
1.7
5.35
4.25
mg/l
0.36
55
958
121
834
1.47
3.92
1.2
1.3
25.48
37.14
u/ml
—
6
55
25
106
2.37
3.90
1.0
1.2
—
—
—
0
0
200
2618
0.75
3.85
1.4
1.5
—
—
—
0
0
124
1742
0.70
3.73
1.3
1.4
—
—
—
0
0
23
96
2.41
3.72
1.3
1.3
—
—
—
0
0
97
650
1.51
3.63
1.9
2.3
247.92
334.20
ug/l
0.39
88
594
270
2144
1.28
3.62
3.5
2.8
—
—
—
0
0
106
724
1.48
3.62
4.2
6.2
0.86
0.90
%
0.58
100
674
411
4892
0.82
3.61
1.2
1.3
3.67
9.15
u/ml
3.06
162
2071
8
13
6.17
3.50
3.5
5.8
—
—
—
0
0
23
99
2.33
3.50
1.3
1.3
—
—
—
0
0
157
1162
1.37
3.45
3.9
3.1
5.21
5.14
kpa
0.51
150
1118
192
1468
1.33
3.42
1.8
1.6
—
—
—
0
0
2229
21314
1.16
3.39
4.4
4.1
14.68
14.45
pmol/l
4.69
2050
19917
46
261
1.77
3.35
1.2
1.5
—
—
—
0
0
150
1110
1.37
3.32
3.9
3.1
1.87
1.59
mmol/l
0.51
128
819
59
360
1.65
3.32
1.2
1.5
—
—
—
0
0
11
310
0.35
3.25
1.4
1.3
35.70
32.98
nmol/l
0.10
11
275
36
191
1.90
3.24
1.1
1.0
—
—
—
0
0
108
761
1.43
3.18
1.3
1.3
2.67
8.01
u/ml
1.61
11
120
405
3423
1.21
3.12
2.6
3.4
0.83
0.82
mmol/l
0.74
373
3234
19
82
2.33
2.91
1.3
1.4
—
—
—
0
0
19
82
2.33
2.91
1.3
1.4
—
—
—
0
0
9
22
4.10
2.88
1.0
1.2
—
—
—
0
0
105
753
1.41
2.84
1.3
1.3
2.60
7.24
u/ml
—
5
82
532
6058
0.85
2.82
2.0
2.3
1775.18
3378.30
umol/l
0.95
476
5457
39
657
0.59
2.81
1.0
1.1
1.56
1.46
u/ml
0.03
16
324
50
308
1.63
2.76
1.2
1.5
—
—
—
0
0
101
731
1.39
2.62
4.6
3.3
25.18
24.75
mmol/l
0.94
96
682
33
185
1.79
2.56
1.3
1.2
—
9.18
—
0
11
2400
24726
0.88
2.53
3.6
3.8
5.65
5.73
mmol/l
3.24
2197
23100
34
194
1.76
2.50
1.3
1.2
—
34.56
—
0
9
92
662
1.40
2.48
1.2
1.3
45.38
35.99
u/ml
0.24
12
63
73
504
1.46
2.47
1.2
1.3
—
—
—
0
0
37
606
0.61
2.43
1.1
1.2
—
—
—
0
0
91
657
1.40
2.42
1.8
2.1
1.26
1.77
ug/l
0.34
72
587
106
785
1.36
2.42
1.5
1.9
1.33
1.46
g/l
1.02
90
681
53
345
1.55
2.38
1.0
1.1
1.48
1.49
g/l
0.10
48
313
7
17
4.12
2.36
1.0
1.1
8.14
24.59
u/l
—
7
17
667
6004
1.14
2.35
1.7
1.8
0.81
0.91
mg/l
0.79
483
4448
35
575
0.60
2.34
1.0
1.1
2.17
3.04
u/ml
0.34
15
278
156
1228
1.28
2.34
1.6
1.5
—
—
—
0
0
15
65
2.31
2.31
3.1
2.3
11.69
16.62
umol/l
1.12
15
65
135
1728
0.77
2.30
1.4
1.4
—
—
—
0
0
74
521
1.43
2.28
2.2
3.0
—
—
—
0
0
27
470
0.57
2.26
2.2
2.5
34.06
99.91
ug/min
2.02
16
294
45
286
1.58
2.25
1.3
1.4
—
—
—
0
0
52
773
0.67
2.24
1.1
1.1
1.70
2.28
u/ml
0.24
21
397
9
29
3.11
2.22
1.0
1.0
—
—
—
0
0
45
287
1.58
2.22
1.3
1.4
—
—
—
0
0
45
287
1.58
2.22
1.3
1.4
—
—
—
0
0
10
35
2.86
2.20
1.2
2.1
—
—
—
0
0
45
288
1.57
2.19
1.3
1.4
—
—
—
0
0
118
904
1.32
2.18
1.3
1.4
—
—
—
0
0
6
14
4.29
2.15
1.0
1.3
—
—
—
0
0
2042
21162
0.90
2.11
3.4
3.5
—
—
—
0
0
45
291
1.55
2.11
1.3
1.4
—
—
—
0
0
704
6408
1.13
2.08
1.6
1.5
—
—
—
0
0
29
169
1.72
2.03
1.1
1.5
5.68
5.81
u/l
0.07
24
143
45
294
1.54
2.03
1.3
1.4
—
—
—
0
0
93
697
1.34
2.02
1.2
1.4
27.87
24.03
u/l
0.55
69
589
519
4642
1.14
2.02
2.5
2.8
674.56
889.93
ng/l
1.70
434
3806
103
785
1.32
2.00
4.7
3.5
48.66
50.32
%
0.24
98
775
396
3481
1.16
1.97
2.0
2.3
13.97
14.24
umol/l
0.28
366
3248
203
1687
1.22
1.94
4.4
3.5
5.91
5.86
kpa
0.37
194
1630
38
242
1.58
1.92
1.8
2.0
22.75
22.43
mg/l
0.01
12
66
28
165
1.70
1.91
4.5
3.0
38782.14
40584.14
ug/l
0.45
28
165
69
498
1.39
1.90
1.1
1.2
2.05
3.49
u/ml
1.01
19
168
63
448
1.41
1.89
2.6
2.9
25.06
24.76
mmol/l
0.24
63
443
96
1248
0.76
1.89
1.4
1.5
—
—
—
0
0
201
1674
1.21
1.88
4.4
3.5
2.40
1.93
mmol/l
1.44
177
1394
272
2331
1.18
1.87
2.2
2.4
35.50
58.41
u/l
0.55
226
2008
153
1872
0.81
1.83
3.9
4.1
4.31
34.30
ug/l
0.98
120
1440
21
115
1.83
1.82
1.3
1.6
—
—
—
0
0
166
1362
1.23
1.81
4.7
2.9
5.00
4.70
kpa
0.78
157
1310
67
486
1.39
1.81
1.1
1.3
2.32
4.47
u/ml
2.30
22
201
102
793
1.30
1.75
2.2
2.0
7.69
4.18
iu/l
1.54
42
305
69
507
1.37
1.74
1.2
1.4
—
—
—
0
0
94
1209
0.77
1.73
1.8
2.0
—
—
—
0
0
5
13
3.85
1.71
1.2
1.1
—
—
—
0
0
21
118
1.78
1.70
2.9
2.5
60.00
49.54
umol/l
0.90
21
101
40
267
1.50
1.68
1.2
1.6
—
—
—
0
0
336
3806
0.87
1.68
1.7
1.8
1.46
1.39
%
1.30
309
3420
29
180
1.62
1.66
1.1
1.2
—
—
—
0
0
50
702
0.71
1.66
1.0
1.1
5.32
5.42
u/ml
0.01
24
381
302
2640
1.16
1.65
3.6
3.8
30.95
31.79
%
0.72
231
1937
32
204
1.57
1.65
1.3
1.5
12.43
11.07
umol/l
0.49
32
189
1137
12027
0.91
1.65
2.4
2.4
—
—
—
0
0
55
393
1.41
1.64
1.4
1.6
—
—
—
0
0
357
3162
1.15
1.63
2.0
2.3
2.48
2.42
g/l
1.20
325
2932
47
327
1.44
1.62
2.0
2.3
—
—
—
0
0
36
534
0.67
1.61
1.0
1.1
2.89
3.34
u/ml
0.10
11
221
24
144
1.67
1.57
1.3
1.7
—
—
—
0
0
54
389
1.39
1.56
2.2
2.3
17.18
16.70
%
0.39
29
189
21
123
1.71
1.50
1.5
1.3
17.00
17.19
u/ml
—
7
21
51
696
0.73
1.46
1.5
1.4
0.43
0.44
nmol/l
0.04
40
567
126
1527
0.82
1.43
1.4
1.5
—
—
—
0
0
116
1417
0.81
1.42
1.3
1.4
—
—
—
0
0
631
5836
1.10
1.39
2.1
2.1
2.81
2.82
mg/l
0.04
538
5026
116
1412
0.81
1.38
1.3
1.4
—
—
—
0
0
727
6774
1.10
1.37
1.3
1.3
1.08
1.50
u/ml
0.61
169
1945
5
17
2.94
1.36
2.0
2.1
—
—
—
0
0
117
1419
0.82
1.35
1.3
1.4
—
—
—
0
0
117
1418
0.82
1.34
1.3
1.4
—
—
—
0
0
52
384
1.36
1.33
2.6
2.6
8.45
8.44
kpa
0.01
52
378
49
661
0.74
1.33
3.1
3.6
706.29
2041.34
u/ml
0.38
42
561
288
2555
1.14
1.32
6.0
5.5
—
—
—
0
0
78
612
1.28
1.32
1.7
1.6
—
—
—
0
0
5
18
2.78
1.28
1.0
1.2
—
—
—
0
0
48
353
1.37
1.27
1.6
1.6
—
—
—
0
0
291
2591
1.14
1.27
3.7
5.7
1.00
1.03
mmol/l
1.72
263
2422
591
6370
0.91
1.27
1.5
1.6
1.39
1.39
mmol/l
0.02
487
5521
18
107
1.69
1.25
1.2
1.2
91.50
95.02
%
—
6
43
201
2307
0.86
1.25
1.3
1.3
30.81
26.63
iu/l
0.94
183
1995
322
2889
1.13
1.25
2.0
2.4
23.41
23.85
%
0.19
264
2502
8
157
0.51
1.24
1.3
1.3
—
—
—
0
0
187
1616
1.17
1.24
5.0
8.0
6.38
8.10
mmol/l
5.83
180
1553
98
798
1.24
1.23
2.1
2.4
152.58
172.33
%
1.78
93
758
5
19
2.63
1.21
1.0
1.1
—
—
—
0
0
473
5138
0.91
1.20
1.2
1.3
14.46
24.55
iu/ml
3.59
112
1636
17
101
1.69
1.19
1.4
1.6
—
—
—
0
0
174
1509
1.16
1.13
2.7
3.7
64.74
79.17
ng/l
2.80
149
1352
35
250
1.40
1.12
1.3
1.4
—
—
—
0
0
62
485
1.28
1.11
1.3
1.6
—
—
—
0
0
30
209
1.44
1.10
1.2
1.6
—
—
—
0
0
36
492
0.73
1.10
2.2
2.6
0.90
0.85
nmol/l
0.16
27
426
8
41
1.95
1.08
1.1
1.1
—
—
—
0
0
33
236
1.40
1.06
1.2
1.6
—
—
—
0
0
7
33
2.12
1.05
1.0
2.3
—
—
—
0
0
59
463
1.28
1.04
1.4
2.0
4.55
5.23
mmol/24h
1.16
54
417
32
229
1.40
1.03
1.3
1.2
—
—
—
0
0
32
229
1.40
1.03
1.3
1.2
—
—
—
0
0
32
229
1.40
1.03
1.3
1.2
—
—
—
0
0
226
2012
1.13
1.03
2.3
2.3
0.23
0.22
g/l
0.77
216
1899
22
146
1.51
1.03
1.4
1.4
1510.27
3282.14
e6/l
0.95
15
96
65
810
0.80
1.03
1.1
1.1
—
—
—
0
0
18
114
1.58
1.02
1.2
1.1
87.00
93.41
%
—
6
46
418
3856
1.10
1.00
3.5
4.0
1.58
1.93
ug/l
1.68
380
3515
62
493
1.26
1.00
1.3
1.6
—
—
—
0
0
19
123
1.55
0.99
1.4
1.5
135.32
133.51
nmol/l
0.04
19
123
9
157
0.57
0.98
1.2
1.6
—
—
—
0
0
5
23
2.18
0.98
2.0
1.9
—
—
—
0
0
0
29
0.00
0.97
0.0
2.1
—
58.72
—
0
24
20
132
1.52
0.97
1.4
1.5
2179.10
78982.01
e6/l
—
10
72
16
101
1.59
0.93
1.4
1.6
—
—
—
0
0
10
55
1.82
0.92
2.7
4.5
—
—
—
0
0
188
1672
1.13
0.90
7.4
7.0
1.17
1.33
mmol/l
2.33
183
1630
23
160
1.44
0.88
3.9
1.8
2.50
1.96
u/field
—
10
83
31
228
1.36
0.88
1.3
1.2
—
—
—
0
0
31
228
1.36
0.88
1.3
1.2
—
—
—
0
0
67
815
0.82
0.88
1.1
1.1
—
—
—
0
0
105
899
1.17
0.85
1.2
1.1
1.31
3.48
u/ml
1.69
12
143
48
381
1.26
0.82
1.4
1.3
—
—
—
0
0
57
462
1.24
0.82
3.5
3.5
24.94
33.36
mg/l
0.84
48
371
57
462
1.24
0.82
3.6
3.5
33.80
66.14
mg/l
1.10
48
370
12
188
0.64
0.79
1.3
1.5
5.61
5.49
mmol/l
0.12
12
181
20
282
0.71
0.79
1.7
1.5
—
—
—
0
0
404
3767
1.08
0.79
2.4
2.7
2.43
2.43
mmol/l
0.08
338
3308
167
1867
0.89
0.78
1.9
2.3
82.35
74.13
ml/min/173m2
2.53
74
688
192
1733
1.11
0.75
6.6
8.8
125.31
123.11
g/l
0.93
187
1687
137
1544
0.88
0.74
1.7
1.6
332.72
294.87
mu/l
0.56
123
1374
12
183
0.65
0.72
1.0
1.1
—
—
—
0
0
5
26
1.92
0.70
1.2
1.0
—
—
—
0
0
228
2086
1.10
0.70
6.1
7.9
1.34
0.99
mmol/l
0.70
179
1634
218
1991
1.10
0.69
3.5
3.4
4.47
4.55
pmol/l
0.59
190
1791
35
442
0.79
0.68
1.1
1.1
5.05
19040.14
iu/ml
—
10
123
10
156
0.64
0.67
1.1
1.4
156.15
222.98
pmol/l
—
10
156
658
6879
0.95
0.64
1.6
1.6
—
—
—
0
0
5
29
1.73
0.64
1.0
1.6
59.60
115.23
ng/l
—
5
29
25
326
0.77
0.64
2.2
2.9
10.23
54.21
u/ml
0.61
25
321
6
104
0.58
0.62
1.2
1.1
—
—
—
0
0
13
88
1.48
0.60
3.7
3.4
—
—
—
0
0
13
88
1.48
0.60
1.2
1.2
—
—
—
0
0
26
200
1.30
0.60
1.3
1.3
70.00
227.75
titre
—
6
40
8
51
1.57
0.60
1.5
1.3
—
—
—
0
0
12
80
1.50
0.59
1.3
1.2
12.25
11.20
u/l
0.16
12
74
0
22
0.00
0.59
0.0
1.1
—
—
—
0
0
0
22
0.00
0.59
0.0
1.0
—
—
—
0
0
200
1841
1.09
0.57
6.2
8.4
95.82
96.05
%
0.16
195
1775
271
2531
1.08
0.55
2.0
2.1
350.48
372.93
nmol/l
1.26
246
2344
27
212
1.28
0.55
1.3
1.8
—
—
—
0
0
8
123
0.65
0.54
1.3
1.1
—
—
—
0
0
12
82
1.47
0.54
3.0
2.3
—
—
—
0
0
9
61
1.48
0.53
1.8
2.8
—
—
—
0
0
9
61
1.48
0.53
1.8
2.8
—
—
—
0
0
225
2090
1.08
0.53
6.2
7.9
12.62
12.98
kpa
0.43
218
2000
225
2090
1.08
0.53
6.2
7.9
5.06
5.09
kpa
0.21
218
1998
28
349
0.80
0.53
1.3
1.5
—
—
—
0
0
309
3281
0.94
0.52
1.8
1.9
—
—
—
0
0
64
554
1.16
0.52
3.5
4.4
3.78
3.83
mmol/l
0.47
64
548
9
133
0.68
0.51
1.6
2.3
28.97
253.59
ug/l
—
9
120
125
1136
1.10
0.49
6.0
7.9
24.65
24.40
mmol/l
0.33
120
1076
14
189
0.74
0.48
2.0
2.8
—
—
—
0
0
33
272
1.22
0.47
1.3
1.7
—
—
—
0
0
21
164
1.28
0.46
1.0
1.3
—
—
—
0
0
11
77
1.43
0.45
1.1
1.1
—
—
—
0
0
54
621
0.87
0.45
1.1
1.2
—
—
—
0
0
26
210
1.24
0.45
1.2
2.1
—
—
—
0
0
213
2275
0.93
0.45
2.4
2.6
0.57
0.70
ug/l
2.64
143
1295
26
319
0.81
0.44
3.4
4.5
18.21
74.85
u/ml
—
7
92
8
56
1.43
0.42
1.0
1.2
—
—
—
0
0
8
56
1.43
0.42
1.0
1.2
—
—
—
0
0
44
378
1.17
0.42
4.6
5.9
404.14
372.95
umol/l
0.61
36
329
158
1466
1.08
0.42
1.7
2.1
12.33
11.96
nmol/l
0.21
144
1334
40
466
0.86
0.41
1.2
1.2
—
—
—
0
0
26
213
1.22
0.40
1.2
1.1
1.08
1.04
ratio
0.69
11
80
40
343
1.17
0.40
1.3
1.7
—
—
—
0
0
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
126
1166
1.08
0.37
7.7
9.4
0.69
0.68
%
0.05
126
1159
18
143
1.26
0.37
1.2
1.4
5.29
6.39
mmol/l
1.10
18
129
16
202
0.79
0.36
1.3
1.2
—
—
—
0
0
53
598
0.88
0.36
1.9
2.2
3.87
4.68
umol/l
0.68
40
436
29
245
1.19
0.35
1.0
1.0
—
—
—
0
0
54
480
1.13
0.34
6.4
3.4
23.84
23.28
mg/l
0.03
30
304
16
200
0.80
0.34
1.3
1.2
—
—
—
0
0
96
1042
0.92
0.33
1.2
1.3
12.48
10.47
u/l
0.69
79
872
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
46
519
0.88
0.33
8.4
3.6
0.42
0.35
u/ml
0.44
26
288
568
5849
0.96
0.32
2.1
2.1
—
—
—
0
0
23
192
1.20
0.32
2.6
2.4
—
—
—
0
0
20
241
0.83
0.31
1.6
1.4
0.91
0.96
g/l
0.20
20
241
44
496
0.89
0.31
1.3
1.7
5468.57
10577.44
e6/l
1.74
30
364
57
514
1.11
0.30
1.2
1.0
1.00
2.87
u/ml
3.33
21
273
25
212
1.18
0.30
1.0
1.1
—
—
—
0
0
40
354
1.13
0.29
1.3
1.6
—
—
—
0
0
40
354
1.13
0.29
1.3
1.6
—
—
—
0
0
23
195
1.18
0.28
1.2
1.3
—
—
—
0
0
35
309
1.13
0.27
1.3
1.2
—
34.00
—
0
6
177
1685
1.05
0.26
1.1
1.1
—
—
—
0
0
18
214
0.84
0.26
1.5
1.3
1.49
1.57
g/l
1.16
18
214
243
2530
0.96
0.26
1.7
1.8
—
—
—
0
0
63
684
0.92
0.24
1.9
1.6
—
—
—
0
0
137
1298
1.06
0.24
2.2
2.9
95.32
137.90
ng/l
1.77
116
1156
486
4744
1.03
0.22
2.0
2.0
—
—
—
0
0
39
352
1.11
0.22
1.4
1.2
—
—
—
0
0
16
189
0.85
0.22
1.6
1.5
29.64
35.90
%
0.34
11
112
24
273
0.88
0.21
1.1
1.1
—
—
—
0
0
160
1672
0.95
0.21
1.8
2.8
26.17
43.63
u/ml
1.91
154
1618
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
387
3771
1.03
0.20
2.0
2.4
131.04
104.76
ug/g
0.50
280
3012
0
14
0.00
0.20
0.0
1.1
—
8.16
—
0
14
53
572
0.93
0.19
1.9
1.8
—
—
—
0
0
13
109
1.19
0.18
1.5
1.7
—
—
—
0
0
13
109
1.19
0.18
1.5
1.7
—
—
—
0
0
15
129
1.16
0.17
1.1
1.4
131.67
159.70
mmol/24h
0.63
15
129
122
1171
1.04
0.16
7.4
9.3
1.46
1.38
%
0.33
122
1165
1311
12995
1.02
0.15
2.8
2.9
101.21
88.87
ug/l
1.09
1233
12281
46
429
1.07
0.15
2.4
2.1
132.37
131.30
g/l
0.12
40
316
9
82
1.10
0.15
1.1
1.2
—
—
—
0
0
17
192
0.88
0.14
1.3
1.3
67.65
74.48
umol/l
0.98
17
192
11
93
1.18
0.14
1.2
1.7
—
—
—
0
0
11
93
1.18
0.14
1.2
1.7
—
—
—
0
0
27
246
1.10
0.14
1.2
1.6
—
—
—
0
0
27
246
1.10
0.14
1.2
1.6
—
—
—
0
0
51
479
1.07
0.14
1.6
1.8
223.57
194.48
pmol/l
0.90
46
446
52
552
0.94
0.14
1.2
1.4
—
—
—
0
0
60
633
0.95
0.13
1.5
1.4
278.14
303.33
ug/g
0.36
30
325
21
190
1.11
0.12
1.2
1.2
—
—
—
0
0
27
248
1.09
0.12
1.1
1.1
—
—
—
0
0
12
104
1.15
0.12
1.3
1.2
—
—
—
0
0
59
561
1.05
0.12
1.2
1.4
169.80
112.06
u/ml
0.42
13
124
41
385
1.07
0.12
1.3
1.1
—
—
—
0
0
24
261
0.92
0.11
1.5
1.6
48.00
57.77
%
0.56
17
167
312
3064
1.02
0.11
3.3
3.5
21.32
21.05
%
0.11
124
1201
210
2053
1.02
0.11
1.2
1.3
142.16
183.47
u/ml
0.50
191
1905
21
229
0.92
0.10
1.3
1.2
—
—
—
0
0
250
2453
1.02
0.10
1.3
1.2
175.42
160.64
iu/ml
0.21
103
938
20
183
1.09
0.10
1.3
1.5
—
—
—
0
0
20
183
1.09
0.10
1.3
1.5
—
—
—
0
0
20
183
1.09
0.10
1.3
1.5
—
—
—
0
0
15
166
0.90
0.09
3.5
3.6
—
—
—
0
0
10
114
0.88
0.09
1.0
1.0
—
—
—
0
0
140
1435
0.97
0.09
2.0
2.1
5.53
7.09
ug/l
0.95
118
1274
19
206
0.92
0.08
1.3
1.5
—
—
—
0
0
5
62
0.81
0.08
1.0
1.0
—
—
—
0
0
14
127
1.10
0.08
1.2
3.0
364.80
169.25
umol/l
—
5
72
6
71
0.84
0.07
1.2
1.7
—
—
—
0
0
100
1024
0.98
0.07
1.7
1.7
—
—
—
0
0
9
88
1.02
0.07
1.4
1.2
—
—
—
0
0
9
88
1.02
0.07
1.7
1.8
—
—
—
0
0
9
88
1.02
0.07
1.7
1.8
—
—
—
0
0
37
354
1.05
0.06
1.4
1.6
—
—
—
0
0
23
217
1.06
0.06
3.5
2.2
32.65
32.13
pg
0.33
23
217
51
496
1.03
0.04
1.0
1.1
—
—
—
0
0
24
229
1.05
0.04
1.3
1.5
281.47
281.48
mosm/kgh2o
0.00
15
185
536
5332
1.01
0.04
2.1
2.1
—
—
—
0
0
143
1414
1.01
0.03
1.4
1.5
—
—
—
0
0
50
490
1.02
0.02
1.1
1.1
—
—
—
0
0
146
1449
1.01
0.02
1.5
1.5
—
—
—
0
0
16
167
0.96
0.01
2.0
1.9
—
—
—
0
0
10
105
0.95
0.00
1.4
1.4
70.90
93.64
nmol/24h
—
10
105
30
301
1.00
0.00
1.1
1.2
—
—
—
0
0
10
104
0.96
0.00
1.0
1.1
—
—
—
0
0
15
148
1.01
0.00
1.1
1.8
—
—
—
0
0
65
652
1.00
0.00
1.2
1.2
—
—
—
0
0
21
213
0.99
0.00
2.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
10.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
1140.25
—
0
8
0
8
0.00
0.00
0.0
1.1
—
29.50
—
0
8
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
34.52
—
0
9
6
61
0.98
-0.00
1.0
1.0
75.57
74.32
ug/l
—
6
52
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
89
1.01
-0.00
1.7
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
21.61
—
0
9
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
9.17
—
0
9
62
620
1.00
-0.00
1.2
1.2
239.34
261.45
u/ml
0.29
35
404
Mortality – FinRegistry
↥Association
Association between endpoint G6_MS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MS | 1.952 [1.74, 2.19] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.613 |
During the follow-up period (1.1.1998 — 31.12.2019), 690 out of 8943 females with G6_MS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_MS | 1.862 [1.65, 2.1] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 4008 males with G6_MS died.
Mortality risk
Mortality risk for people of age
years, who have G6_MS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.221% | 0.428% |
| 5 | 1.32% | 2.309% |
| 10 | 3.478% | 5.606% |
| 15 | 6.353% | 10.683% |
| 20 | 10.966% | 17.637% |
Relationships between endpoints
↥Index endpoint: G6_MS – MS-disease / Multiple Sclerosis
GWS hits: 14
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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