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Ankylosing spondylitis

M13_ANKYLOSPON

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M45
Hospital discharge: ICD-9 7200
Hospital discharge: ICD-8 7124
Cause of death: ICD-10 M45
Cause of death: ICD-9 7200
Cause of death: ICD-8 7124

2 out of 7 registries used, show all original rules.

3278

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Check minimum number of events None

3278

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Include endpoints None

3278

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Remove individuals based on genotype QC

3162

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M13_ANKYLOSPON

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M45-M49
Name in latin Spondylarthritis/spondylitis ancylopoetica

Summary Statistics

Key figures

All Female Male
Number of individuals 3162 1475 1687
Unadjusted prevalence (%) 0.77 0.64 0.93
Mean age at first event (years) 42.03 41.39 42.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.38 [0.87, 2.19] 1.8e-1 244
15 years 0.01 1.03 [0.69, 1.55] 8.8e-1 102
5 years 0.00 1.07 [0.68, 1.68] 7.6e-1 29
1 year 0.00 3.00 [1.65, 5.45] 3.2e-4 14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_ANKYLOSPON – Ankylosing spondylitis
GWS hits: 17

Survival analyses between endpoints

Plot

before Ankylosing spondylitis
after Ankylosing spondylitis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ankylosing spondylitis