Risteys · O15_DELIV

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O82 Cause of death: ICD-10 — O82 2 out of 7 registries used, show all original rules.	19446
4. Check minimum number of events None	19446
5. Include endpoints None	19446
6. Filter based on genotype QC (FinnGen only)	19446

	All	Female	Male
Number of individuals
Whole population	137831	137831	-
Only index persons	136771	136771	-
Unadjusted period prevalence (%)
Whole population	3.95	3.95	-
Only index persons	5.03	5.03	-
Median age at first event (years)
Whole population	-	30.79	-
Only index persons	-	30.78	-

	All	Female	Male
Number of individuals	19446	19446	-
Unadjusted period prevalence (%)	6.63	6.63	-
Median age at first event (years)	31.24	31.24	-

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
2206: Matched controls
17481

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

+∞

323.0

1167

O32.1

ICD-10 Finland

Maternal care for breech presentation

110.7

323.0

401

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

66.8

323.0

567

SPAT1197

SPAT

Extensive health check-up of expecting family

51.6

323.0

909

234

SPAT1399

SPAT

Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.

62.6

323.0

413

SPAT1380

SPAT

Postpartum check-up

189.5

323.0

767

SPAT1379

SPAT

Health check-up of pregnant person

41.2

323.0

1010

351

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

67.7

323.0

895

174

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

94.8

323.0

556

O82.0

ICD-10 Finland

Delivery by elective caesarean section

+∞

323.0

1003

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

724.7

323.0

1986

215

O99.80

ICD-10 Finland

The fear of childbirth

104.5

323.0

452

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

49.3

323.0

507

105

Z39.2

ICD-10 Finland

Routine postpartum follow-up

143.6

323.0

904

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

48.6

323.0

440

Z35.8

ICD-10 Finland

Supervision of other high-risk pregnancies

82.6

323.0

521

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

71.6

323.0

739

122

W78

ICPC

Pregnancy

23.4

323.0

1080

687

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

56.2

323.0

1277

417

Z34.0

ICD-10 Finland

Supervision of normal first pregnancy

33.7

323.0

719

247

Z32.1

ICD-10 Finland

Pregnancy confirmed

15.0

323.0

612

436

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

58.6

323.0

496

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

85.5

323.0

766

108

MA5AE

NOMESCO Finland

Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation

59.7

315.4

397

O68.0

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly

120.7

310.9

358

WX307

NOMESCO Finland

Obstetric epidural analgesia

113.0

309.7

359

MA3AE

NOMESCO Finland

Combined first trimester screening

43.2

296.5

396

Z36.0

ICD-10 Finland

Antenatal screening for chromosomal anomalies

33.0

286.6

407

119

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

31.6

260.8

374

112

O80.0

ICD-10 Finland

Spontaneous vertex delivery

+∞

256.3

263

WX320

NOMESCO Finland

Spinalanesthesy

6.9

255.4

776

1270

Z37.0

ICD-10 Finland

Single live birth

43.5

243.6

325

O63.0

ICD-10 Finland

Prolonged first stage (of labour)

118.8

238.3

276

W92

ICPC

Compl labour/ delivery livebirth

121.7

233.6

270

MA1AE

NOMESCO Finland

Ultrasound examination of early pregnancy (before 12. postmenstrual week)

9.9

226.3

515

519

ZXD05

NOMESCO Finland

Urgent procedure

5.1

223.8

945

2251

W84

ICPC

Pregnancy high risk

55.0

222.8

285

MA2XE

NOMESCO Finland

Other obstetric ultrasound examination

71.7

196.8

242

O13

ICD-10 Finland

Gestational [pregnancy-induced] hypertension

53.8

193.1

248

O36.6

ICD-10 Finland

Maternal care for excessive fetal growth

76.3

184.4

225

WX306

NOMESCO Finland

Lumbar epidural anesthesy

13.8

172.5

327

218

6500B

ICD-9 Finland

Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]

+∞

159.2

165

SPAT1317

SPAT

Planned health check-up monitoring, health check-up performed based on individual need

5.3

149.8

545

1023

O64.0

ICD-10 Finland

Obstructed labour due to incomplete rotation of fetal head

99.0

146.1

173

W90

ICPC

Uncompl labour/delivery livebirth

76.6

145.8

178

O48

ICD-10 Finland

Prolonged pregnancy

110.0

142.5

167

O82.11

ICD-10 Finland

Childbirth with an emergency caesarean section in an emergency

1296.4

142.4

150

O35.1

ICD-10 Finland

Maternal care for (suspected) chromosomal abnormality in fetus

46.1

141.6

187

65000

ICD-8 Finland

Delivery without mention of complication, Occipital presentation

+∞

139.7

145

W85

ICPC

Gestational diabetes

22.3

139.0

219

Z35.9

ICD-10 Finland

Supervision of high-risk pregnancy, unspecified

45.8

136.9

181

SPAT1196

SPAT

Monitoring of normal pregnancy

81.4

133.7

162

MAC10

NOMESCO Finland

Antepartum dilatation of cervical canal

96.2

132.9

158

O36.5

ICD-10 Finland

Maternal care for poor fetal growth

69.5

125.3

155

SPAT1200

SPAT

Guidance for breast-feeding and breast care

52.7

120.2

155

SPAT1189

SPAT

Other ultrasound examination during pregnancy

22.7

119.6

187

O42.9

ICD-10 Finland

Premature rupture of membranes, unspecified

61.5

115.2

145

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

7.2

113.8

309

387

MAA00

NOMESCO Finland

Amniocentesis

45.4

113.4

150

O64.1

ICD-10 Finland

Obstructed labour due to breech presentation

77.1

112.3

137

MAB20

NOMESCO Finland

Failed external version

336.0

110.9

121

XMA22

NOMESCO Finland

General examination of pregnant woman

60.0

106.9

135

OAA12

SPAT

50.9

102.6

133

Z34

ICD-10 Finland

Supervision of normal pregnancy

32.2

99.2

141

MAC40

NOMESCO Finland

Pharmacological induction or advancement of labor

120.0

98.8

115

O99.3

ICD-10 Finland

Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium

53.3

98.7

127

O61.0

ICD-10 Finland

Failed medical induction of labour

76.6

97.5

119

O41.1

ICD-10 Finland

Infection of amniotic sac and membranes

113.4

93.2

109

SPAT1195

SPAT

Antenatal classes

34.1

92.7

130

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

76.4

90.1

110

O26.82

ICD-10 Finland

Exhaustion and fatigue pregnancy-related

40.5

89.5

121

O80.8

ICD-10 Finland

Other single spontaneous delivery

+∞

88.2

O47.1

ICD-10 Finland

False labour at or after 37 completed weeks of gestation

136.7

86.0

O60

ICD-10 Finland

Preterm labour and delivery

23.6

85.7

132

WYA40

NOMESCO Finland

Assessment of oral health and treatment needs for family expecting first child

30.9

85.1

122

OAA11

SPAT

7.3

82.7

219

260

Z35.0

ICD-10 Finland

Supervision of pregnancy with history of infertility

21.7

80.5

127

O14.9

ICD-10 Finland

Pre-eclampsia, unspecified

98.2

80.1

Z39.1

ICD-10 Finland

Care and examination of lactating mother

97.1

79.2

O21.9

ICD-10 Finland

Vomiting of pregnancy, unspecified

25.5

79.0

119

B01AB05

ATC

enoxaparin; parenteral

2.9

79.0

606

2014

W29

ICPC

Pregnancy symptom/complaint other

17.4

78.3

133

MAX99

NOMESCO Finland

Assistance to normal delivery

123.8

77.6

Z3232

NOMESCO Finland

Midwife

7.3

76.3

202

239

O24.0

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent

24.5

73.7

112

O02.1

ICD-10 Finland

Missed abortion

7.6

73.4

188

211

O81.4

ICD-10 Finland

Vacuum extractor delivery

639.2

72.8

SPAT1373

SPAT

Combined screening in early pregnancy

27.2

71.1

105

ZXE00

NOMESCO Finland

One hour or less

2.4

71.0

917

4043

O10.0

ICD-10 Finland

Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium

47.5

70.3

Z35.2

ICD-10 Finland

Supervision of pregnancy with other poor reproductive or obstetric history

84.3

68.0

O26.88

ICD-10 Finland

Other specified pregnancy-related conditions

61.3

65.3

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

61.3

65.3

O35.8

ICD-10 Finland

Maternal care for other (suspected) fetal abnormality and damage

24.3

63.7

O63.1

ICD-10 Finland

Prolonged second stage (of labour)

30.9

63.0

O75.6

ICD-10 Finland

Delayed delivery after spontaneous or unspecified rupture of membranes

70.2

62.5

O36.8

ICD-10 Finland

Maternal care for other specified fetal problems

69.3

61.6

MAC96

NOMESCO Finland

Other induction or advancement of labour

529.2

60.4

O47.9

ICD-10 Finland

False labour, unspecified

55.8

58.9

O20.9

ICD-10 Finland

Haemorrhage in early pregnancy, unspecified

14.6

56.4

102

O72.1

ICD-10 Finland

Other immediate postpartum haemorrhage

79.4

56.1

LGA10

NOMESCO Finland

Sterilisation by destruction or division of Fallopian tubes

29.5

54.7

SPAT1357

SPAT

Monitoring of problem during pregnancy

77.0

54.2

O14.1

ICD-10 Finland

Severe pre-eclampsia

55.4

53.4

O24.9

ICD-10 Finland

Diabetes mellitus in pregnancy, unspecified

55.4

53.4

Z39.0

ICD-10 Finland

Care and examination immediately after delivery

87.0

53.4

O68.8

ICD-10 Finland

Labour and delivery complicated by other evidence of fetal stress

462.1

52.7

O41.0

ICD-10 Finland

Oligohydramnios

40.8

52.1

O20.0

ICD-10 Finland

Threatened abortion

16.3

51.5

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

64.2

50.6

Z32.0

ICD-10 Finland

Pregnancy, not (yet) confirmed

8.1

50.3

122

125

SPAT1375

SPAT

Structural ultrasound screening, weeks 18+0-21+6

+∞

49.7

O14.0

ICD-10 Finland

Mild to moderate pre-eclampsia

33.1

49.2

O03.9

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, without complication

6.4

49.0

140

183

O26.6

ICD-10 Finland

Liver disorders in pregnancy, childbirth and the puerperium

50.5

48.0

O99.0

ICD-10 Finland

Anaemia complicating pregnancy, childbirth and the puerperium

68.6

47.8

Z36.8

ICD-10 Finland

Other antenatal screening

30.9

47.7

LX1AE

NOMESCO Finland

Gynecological ultrasound examination as part of clinical examination

2.7

47.1

366

1181

O46.9

ICD-10 Finland

Antepartum haemorrhage, unspecified

67.4

46.9

MAE00

NOMESCO Finland

Outlet vacuum delivery

20.6

45.9

O02.0

ICD-10 Finland

Blighted ovum and nonhydatidiform mole

8.3

45.6

109

Z87.5

ICD-10 Finland

Personal history of complications of pregnancy, childbirth and the puerperium

74.4

45.1

N02BE01

ATC

paracetamol; systemic, rectal

2.2

44.3

1824

12017

O40

ICD-10 Finland

Polyhydramnios

63.8

44.2

O30.0

ICD-10 Finland

Twin pregnancy

37.5

44.0

O21

ICD-10 Finland

Excessive vomiting in pregnancy

19.7

43.4

O68.2

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly with meconium in amniotic fluid

103.3

43.4

W05

ICPC

Pregnancy vomiting/nausea

21.3

43.3

WZB00

SPAT

0.3

43.2

2133

O72.2

ICD-10 Finland

Delayed and secondary postpartum haemorrhage

54.7

42.4

NE1AG

NOMESCO Finland

MRI pelvimetry with high intensity magnet

190.1

41.9

O86.0

ICD-10 Finland

Infection of obstetric surgical wound

53.7

41.5

WX234

NOMESCO Finland

Paracervical blockade

12.9

40.7

O28.8

ICD-10 Finland

Other abnormal findings on antenatal screening of mother

66.2

39.6

MAC01

NOMESCO Finland

Rupture of aminiotic membrane for induction of labor

45.9

39.0

O44.0

ICD-10 Finland

Placenta praevia specified as without haemorrhage

121.2

38.9

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

2.0

38.4

692

3303

Z35.5

ICD-10 Finland

Supervision of elderly primigravida

49.6

38.0

OAA10

SPAT

5.7

37.4

116

169

O65.4

ICD-10 Finland

Obstructed labour due to fetopelvic disproportion, unspecified

54.2

37.0

W27

ICPC

Fear of complications of pregnancy

34.4

36.9

O26.7

ICD-10 Finland

Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium

43.1

36.3

WX600

NOMESCO Finland

Single shot through catheter

11.5

36.3

MA5AE

SPAT

165.4

36.3

O66.5

ICD-10 Finland

Failed application of vacuum extractor and forceps, unspecified

165.4

36.3

G03GA01

ATC

chorionic gonadotrophin; parenteral

4.3

36.2

145

280

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

1.9

36.1

770

3887

O47

ICD-10 Finland

False labour

86.8

36.0

O91.2

ICD-10 Finland

Nonpurulent mastitis associated with childbirth

71.1

36.0

O72.0

ICD-10 Finland

Third-stage haemorrhage

31.1

35.4

Z36.4

ICD-10 Finland

Antenatal screening for fetal growth retardation using ultrasound and other physical methods

+∞

35.3

SPAT1246

SPAT

Screening of depression or other psychiatric problem

3.2

35.1

205

541

WX322

NOMESCO Finland

Combined spinal-epidural analgesia in obstetrics

28.9

34.7

O30.00

ICD-10 Finland

Twin pregnancy with separate amniotic and chorionic sacs

41.3

34.5

C07AG01

ATC

labetalol; systemic

11.0

34.5

WX230

NOMESCO Finland

Plexus blockade of nervus pudendus

157.1

34.4

O23.5

ICD-10 Finland

Infections of the genital tract in pregnancy

+∞

34.3

MA3AE

SPAT

107.5

34.2

O42.0

ICD-10 Finland

Premature rupture of membranes, onset of labour within 24 hours

31.6

33.4

Z30.2

ICD-10 Finland

Sterilization

2.6

33.4

266

861

Z36.9

ICD-10 Finland

Antenatal screening, unspecified

36.3

33.0

MAE20

NOMESCO Finland

Failed vacuum delivery

288.0

32.8

O44.1

ICD-10 Finland

Placenta praevia with haemorrhage

102.0

32.4

LGA20

NOMESCO Finland

Sterilisation by constriction of Fallopian tubes

16.5

32.3

LGA00

NOMESCO Finland

Sterilisation by ligature of Fallopian tubes

25.3

31.6

O70.1

ICD-10 Finland

Second degree perineal laceration during delivery

47.2

31.6

SPAT1249

SPAT

Treatment-related counselling outside office

1.7

31.3

986

5573

MBA96

NOMESCO Finland

Other removal of retained products of conception after delivery or abortion

11.3

30.6

G03DA04

ATC

progesterone; systemic, rectal, vaginal

3.1

29.8

181

491

SPAT1391

SPAT

Counselling and guidance related to family situation

8.3

29.7

TMW99

NOMESCO Finland

Other minor surgical procedure in obstetrics

93.9

29.6

O35.9

ICD-10 Finland

Maternal care for (suspected) fetal abnormality and damage, unspecified

93.9

29.6

FM1QE

NOMESCO Finland

Extensive ultrasound of fetal heart

35.8

29.3

O03.4

ICD-10 Finland

Spontaneous abortion, Incomplete, without complication

8.4

28.7

H01CA02

ATC

nafarelin; nasal

4.2

28.7

116

226

O61.1

ICD-10 Finland

Failed instrumental induction of labour

91.1

28.7

G03GB02

ATC

clomifene; oral

4.0

27.9

120

248

O68.3

ICD-10 Finland

Labour and delivery complicated by biochemical evidence of fetal stress

68.4

27.7

O68.1

ICD-10 Finland

Labour and delivery complicated by meconium in amniotic fluid

+∞

27.6

J01CA08

ATC

pivmecillinam; oral

1.6

27.5

1132

6811

O32.2

ICD-10 Finland

Maternal care for transverse and oblique lie

242.3

27.1

MBC30

NOMESCO Finland

Repair of partial rupture of perineum

46.9

27.0

O34.1

ICD-10 Finland

Maternal care for tumour of corpus uteri

124.5

26.9

MBC10

NOMESCO Finland

Repair of obstetric laceration of vagina

85.7

26.8

OAA70

SPAT

9.8

26.8

O84.2

ICD-10 Finland

Multiple delivery, all by caesarean section

+∞

26.7

Z35

ICD-10 Finland

Supervision of high-risk pregnancy

22.0

26.6

N61

ICD-10 Finland

Inflammatory disorders of breast

5.1

26.5

143

O99.1

ICD-10 Finland

Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium

40.2

26.3

Z35.7

ICD-10 Finland

Supervision of high-risk pregnancy due to social problems

233.9

26.2

TMA00

NOMESCO Finland

Episiotomy

53.0

26.0

O64.8

ICD-10 Finland

Obstructed labour due to other malposition and malpresentation

83.0

25.9

R3110

NOMESCO Finland

Psychosocial training

14.3

25.7

SPAT1263

SPAT

Sampling

1.6

25.5

972

5684

WYA50

NOMESCO Finland

Student oral health check consistent with decree to assess need for oral health guidance and services

0.3

25.5

1589

O86.1

ICD-10 Finland

Other infection of genital tract following delivery

225.5

25.3

O36.9

ICD-10 Finland

Maternal care for fetal problem, unspecified

29.0

25.2

Z39

ICD-10 Finland

Postpartum care and examination

116.3

25.1

OAA41

SPAT

6.5

25.0

ZXD00

NOMESCO Finland

Emergency procedure

5.8

24.7

104

MBA00

NOMESCO Finland

Vacuum aspiration from uterus after delivery or abortion

6.0

24.0

OAB30

SPAT

21.3

23.9

O33.3

ICD-10 Finland

Maternal care for disproportion due to outlet contraction of pelvis

48.1

23.3

O99.4

ICD-10 Finland

Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium

108.2

23.2

O99.6

ICD-10 Finland

Diseases of the digestive system complicating pregnancy, childbirth and the puerperium

32.1

23.0

MA4AT

NOMESCO Finland

Chorion biopsy with ultrasound guidance

32.1

23.0

O21.0

ICD-10 Finland

Mild hyperemesis gravidarum

22.8

22.4

O85

ICD-10 Finland

Puerperal sepsis

72.2

22.3

O62.0

ICD-10 Finland

Primary inadequate contractions

27.7

21.6

XMA00

NOMESCO Finland

27.7

21.6

G03GA05

ATC

follitropin alfa; parenteral

4.0

21.5

186

W18

ICPC

Post-partum symptom/complaint other

100.1

21.4

O99.5

ICD-10 Finland

Diseases of the respiratory system complicating pregnancy, childbirth and the puerperium

30.1

21.3

ZXD10

NOMESCO Finland

Scheduled procedure

1.6

21.0

719

4031

O86.8

ICD-10 Finland

Other specified puerperal infections

+∞

20.9

A02BC01

ATC

omeprazole; systemic

1.8

20.9

422

2028

OAB42

SPAT

0.3

20.8

1273

O20.8

ICD-10 Finland

Other haemorrhage in early pregnancy

96.1

20.4

ZYC02

SPAT

0.2

20.4

758

SPAT1283

SPAT

Restricted health certificate

1.6

20.3

750

4274

MBA03

NOMESCO Finland

Curettage of uterus after delivery or abortion

5.4

20.0

O69.1

ICD-10 Finland

Labour and delivery complicated by cord around neck, with compression

50.0

19.6

O75.7

ICD-10 Finland

Vaginal delivery following previous caesarean section

50.0

19.6

G02CB01

ATC

bromocriptine; systemic

4.9

19.6

111

O12.1

ICD-10 Finland

Gestational proteinuria

64.1

19.5

E66.01

ICD-10 Finland

Obesity due to excess calories

2.2

19.4

209

784

FM1NE

NOMESCO Finland

Ultrasound examination of fetal heart

34.7

19.1

O61.8

ICD-10 Finland

Other failed induction of labour

+∞

19.0

MBA40

NOMESCO Finland

Pharmacological evacuation of uterus after abortion

7.4

19.0

P01AB01

ATC

metronidazole; oral, rectal

1.6

19.0

797

4669

R2110

NOMESCO Finland

Giving the first information

2.5

18.9

164

551

M01AE01

ATC

ibuprofen; systemic, rectal

1.8

18.7

1976

14384

O12.0

ICD-10 Finland

Gestational oedema

61.4

18.6

M54.5

ICD-10 Finland

Low back pain

1.6

18.6

644

3592

O62.1

ICD-10 Finland

Secondary uterine inertia

22.4

18.5

N97.9

ICD-10 Finland

Female infertility, unspecified

2.8

18.3

127

377

O42.1

ICD-10 Finland

Premature rupture of membranes, onset of labour after 24 hours

17.2

18.2

Z35.4

ICD-10 Finland

Supervision of pregnancy with grand multiparity

+∞

18.1

O45.9

ICD-10 Finland

Premature separation of placenta, unspecified

38.4

18.0

O03.1

ICD-10 Finland

Spontaneous abortion, Incomplete, complicated by delayed or excessive haemorrhage

7.5

18.0

O34.3

ICD-10 Finland

Maternal care for cervical incompetence

26.0

17.9

N97.0

ICD-10 Finland

Female infertility associated with anovulation

3.7

17.8

177

V252A

ICD-9 Finland

Contraceptive management, Sterilisation

0.2

17.2

604

O69.0

ICD-10 Finland

Labour and delivery complicated by prolapse of cord

+∞

17.1

Z32

ICD-10 Finland

Pregnancy examination and test

11.5

17.1

XMA20

NOMESCO Finland

Early examination of pregnancy

44.0

17.0

SPAT1381

SPAT

Extensive health check-up at 4 months of age

44.0

17.0

KAY40

NOMESCO Finland

0.4

16.3

1230

SPAT1187

SPAT

General ultrasound examination in early pregnancy

15.0

16.2

G03GA02

ATC

human menopausal gonadotrophin; parenteral

3.1

16.1

236

J01DA01

ATC

[U] cefalexin; systemic

1.5

16.1

1224

8052

O04.9

ICD-10 Finland

Medical abortion, complete or unspecified, without complication

2.0

16.0

225

942

O28.3

ICD-10 Finland

Abnormal ultrasonic finding on antenatal screening of mother

26.3

15.9

O36.3

ICD-10 Finland

Maternal care for signs of fetal hypoxia

26.3

15.9

O32.0

ICD-10 Finland

Maternal care for unstable lie

143.7

15.9

Z35.6

ICD-10 Finland

Supervision of very young primigravida

75.9

15.9

G03GA06

ATC

follitropin beta; parenteral

4.2

15.8

119

OAB38

SPAT

0.1

15.8

467

Z86.4

ICD-10 Finland

Personal history of psychoactive substance abuse

33.5

15.4

MAW96

NOMESCO Finland

Other operation in pregnancy or at delivery

23.0

15.4

EB1AA

NOMESCO Finland

Tooth X-ray examination

1.4

15.1

1148

7509

W01

ICPC

Question of pregnancy

3.7

14.9

146

A10AC01

ATC

insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)

2.5

14.8

121

394

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.5

14.8

793

4830

SPAT1262

SPAT

Handing over of treatment supplies

1.9

14.8

225

972

W03

ICPC

Antepartum bleeding

13.9

14.7

SGA01

NOMESCO Finland

Tooth opening as first aid

1.7

14.6

337

1671

O65.3

ICD-10 Finland

Obstructed labour due to pelvic outlet and mid-cavity contraction

31.9

14.6

-2

ICD-10 Finland

0.3

14.4

824

SPAT1190

SPAT

Insertion or removal of intrauterine contraceptive device

1.9

14.2

211

906

O64.3

ICD-10 Finland

Obstructed labour due to brow presentation

127.6

14.0

SPAT1382

SPAT

Extensive health check-up at 18 months of age

127.6

14.0

8502

FHL

Evacuation and abrasion

2.5

14.0

117

388

SPAT1364

SPAT

Health check-up performed during second study year in students of upper secondary schools, vocational schools etc.

0.4

13.8

1221

SPAT1153

SPAT

Removal of sutures

1.6

13.6

467

2566

TLW00

NOMESCO Finland

Insemination

4.7

13.5

OAB39

SPAT

0.4

13.4

996

N71.0

ICD-10 Finland

Acute inflammatory disease of uterus

2.8

13.4

249

O33.1

ICD-10 Finland

Maternal care for disproportion due to generally contracted pelvis

22.8

13.4

O75.3

ICD-10 Finland

Other infection during labour

+∞

13.3

O80.9

ICD-10 Finland

Single spontaneous delivery, unspecified

+∞

13.3

O33.9

ICD-10 Finland

Maternal care for disproportion, unspecified

45.2

13.3

MCA00

NOMESCO Finland

Upper uterine segment caesarean section

45.2

13.3

MBA04

NOMESCO Finland

Curettage of uterus after delivery

63.8

13.1

W94

ICPC

Puerperal mastitis

25.3

13.1

O75.0

ICD-10 Finland

Maternal distress during labour and delivery

25.3

13.1

O30.01

ICD-10 Finland

Twin pregnancy with a shared chorionic sac and a separate amniotic sac

119.6

13.1

O75.2

ICD-10 Finland

Pyrexia during labour, not elsewhere classified

119.6

13.1

XLA10

NOMESCO Finland

2.3

13.1

129

465

WZA10

SPAT

0.1

12.8

387

SPAT1273

SPAT

Structured assessment of psychoactive substance / tobacco use

2.2

12.6

138

521

KAY20

NOMESCO Finland

0.4

12.6

1078

O23.1

ICD-10 Finland

Infections of bladder in pregnancy

33.9

12.6

L03

ICPC

Low back symptom/complaint

1.5

12.5

494

2799

OAA48

SPAT

6.8

12.4

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.5

12.4

468

2624

G03GA04

ATC

urofollitropin; parenteral

3.5

12.4

132

R51.80

ICD-10 Finland

Headache

1.6

12.4

365

1928

Z36.2

ICD-10 Finland

Other antenatal screening based on amniocentesis

+∞

12.4

SPAT1393

SPAT

Guidance to support interaction between parent and child

23.9

12.3

O65.1

ICD-10 Finland

Obstructed labour due to generally contracted pelvis

23.9

12.3

SPAT1301

SPAT

No procedures

1.5

12.2

596

3529

O45.8

ICD-10 Finland

Other premature separation of placenta

111.6

12.2

WZC00

SPAT

0.4

12.1

895

SPAT1192

SPAT

Gynaecological examination

1.5

12.0

425

2345

SAA01

NOMESCO Finland

Simple examination of mouth

1.4

12.0

1630

11610

QXA70

SPAT

0.1

11.9

287

IHZ05

SPAT

0.3

11.8

713

Z35.1

ICD-10 Finland

Supervision of pregnancy with history of abortive outcome

20.5

11.8

SPAT1383

SPAT

Extensive health check-up at 4 years of age

31.9

11.7

SPAT1128

SPAT

Instruction of pelvic floor / sphincter exercises

7.7

11.5

J01DB01

ATC

cefalexin; oral

1.4

11.4

1679

12060

O41.8

ICD-10 Finland

Other specified disorders of amniotic fluid and membranes

+∞

11.4

O65.5

ICD-10 Finland

Obstructed labour due to abnormality of maternal pelvic organs

+∞

11.4

O82.9

ICD-10 Finland

Delivery by caesarean section, unspecified

+∞

11.4

N39.0

ICD-10 Finland

Urinary tract infection, site not specified

1.6

11.3

296

1514

MWA00

NOMESCO Finland

Repair of wound dehiscence in obstetric surgery

103.5

11.3

MAC02

NOMESCO Finland

Rupture of aminiotic membrane for advancement of labor

103.5

11.3

OAB36

SPAT

0.2

11.2

400

O28.1

ICD-10 Finland

Abnormal biochemical finding on antenatal screening of mother

25.5

11.2

LC2HE

NOMESCO Finland

Hystero-salpingography with ultrasound

2.3

10.9

102

359

WX740

NOMESCO Finland

Nitrogen oxide therapy

16.0

10.9

MBA05

NOMESCO Finland

Curettage of uterus after abortion

7.7

10.7

MAB10

NOMESCO Finland

External version

21.3

10.6

LCH11

NOMESCO Finland

Pharmacologic abortion

2.0

10.6

138

562

B01AB10

ATC

tinzaparin; parenteral

2.3

10.5

103

372

H04AA01

ATC

glucagon; nasal, parenteral

2.6

10.5

234

IHZ02

SPAT

0.2

10.5

418

O90.2

ICD-10 Finland

Haematoma of obstetric wound

51.7

10.4

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.4

10.4

1038

6933

L02AE01

ATC

buserelin; implant, nasal, parenteral

3.1

10.3

151

A05AA02

ATC

ursodeoxycholic acid; oral

4.3

10.2

O21.1

ICD-10 Finland

Hyperemesis gravidarum with metabolic disturbance

27.9

10.0

LAA10

NOMESCO Finland

Percutaneous or transvaginal puncture and recovery of oocyte

3.2

10.0

130

O62.2

ICD-10 Finland

Other uterine inertia

19.9

9.8

O26.9

ICD-10 Finland

Pregnancy-related condition, unspecified

34.5

9.8

XLA00

NOMESCO Finland

8.0

9.7

Z76.0

ICD-10 Finland

Issue of repeat prescription

0.6

9.6

192

2326

E10.9

ICD-10 Finland

Type 1 diabetes mellitus, Without complications

2.1

9.6

105

397

LA2AE

NOMESCO Finland

Ultrasound examination of ovarian cyst

3.5

9.6

104

O00.9

ICD-10 Finland

Ectopic pregnancy, unspecified

4.7

9.6

W17

ICPC

Post-partum bleeding

+∞

9.5

SFA20

NOMESCO Finland

Filling on two surfaces of tooth

1.3

9.5

1172

8042

O33.2

ICD-10 Finland

Maternal care for disproportion due to inlet contraction of pelvis

87.5

9.4

A03

ICPC

Fever

1.4

9.4

466

2753

K02.1

ICD-10 Finland

Caries of dentine

1.3

9.2

1273

8862

L02BG04

ATC

letrozole; oral

1.9

9.2

141

613

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

0.5

9.1

914

ZXE10

NOMESCO Finland

More than one and less than three hours

1.4

9.1

577

3558

W19

ICPC

Lactation symptom/complaint

18.6

9.0

1412

FHL

Laparoscopy and sterilization

0.2

8.9

362

TLW12

NOMESCO Finland

Insertion of frozen embryo

5.5

8.8

Z30.1

ICD-10 Finland

Insertion of (intrauterine) contraceptive device

1.5

8.8

359

2035

SPAT1193

SPAT

Pap smear

1.5

8.8

321

1778

O00.1

ICD-10 Finland

Tubal pregnancy

3.8

8.6

G01AA10

ATC

clindamycin; vaginal

1.5

8.6

300

1645

MBA30

NOMESCO Finland

Manual removal of placenta from delivered uterus

15.9

8.6

O24.1

ICD-10 Finland

Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, non-insulin-dependent

15.9

8.6

O67.9

ICD-10 Finland

Intrapartum haemorrhage, unspecified

+∞

8.6

W28

ICPC

Limited function/disability (W)

+∞

8.6

O71.4

ICD-10 Finland

Obstetric high vaginal laceration

+∞

8.6

O64.4

ICD-10 Finland

Obstructed labour due to shoulder presentation

+∞

8.6

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

1.4

8.5

446

2653

H01CC01

ATC

ganirelix; parenteral

3.5

8.5

O36.0

ICD-10 Finland

Maternal care for rhesus isoimmunization

79.6

8.5

O10.9

ICD-10 Finland

Unspecified pre-existing hypertension complicating pregnancy, childbirth and the puerperium

79.6

8.5

O41.9

ICD-10 Finland

Disorder of amniotic fluid and membranes, unspecified

79.6

8.5

E10.1

ICD-10 Finland

Type 1 diabetes mellitus, With ketoacidosis

3.2

8.5

111

SPAT1303

SPAT

Counselling and guidance related to growth and development

3.5

8.4

D10

ICPC

Vomiting

1.6

8.4

226

1165

T81.4

ICD-10 Finland

Infection following a procedure, not elsewhere classified

1.8

8.4

157

729

Z31.5

ICD-10 Finland

Genetic counselling

2.0

8.3

109

448

K04.0

ICD-10 Finland

Pulpitis

1.6

8.3

210

1065

6320A

ICD-9 Finland

Missed abortion[ABORTUS INHIBITUS (""""MISSED ABORTION"""")]

3.5

8.3

G01AF05

ATC

econazole; vaginal

1.8

8.3

144

653

G03AC03

ATC

levonorgestrel; systemic

1.6

8.3

206

1038

SFA10

NOMESCO Finland

Fillning on one surface of tooth

1.3

8.2

1187

8257

A10AE05

ATC

insulin detemir; parenteral

2.1

8.2

372

E66.9

ICD-10 Finland

Obesity, unspecified

2.2

8.1

313

A10AB05

ATC

insulin aspart; parenteral (insulins and analog. for injection, fast-acting)

1.9

8.1

113

477

O99.8

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

29.2

8.0

O33.5

ICD-10 Finland

Maternal care for disproportion due to unusually large fetus

29.2

8.0

Z11.3

ICD-10 Finland

Special screening examination for infections with a predominantly sexual mode of transmission

0.5

8.0

1102

O03.6

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, complicated by delayed or excessive haemorrhage

9.8

8.0

Z71.8

ICD-10 Finland

Other specified counselling

1.4

7.9

567

3554

OAB34

SPAT

14.8

7.8

J01EA01

ATC

trimethoprim; systemic

1.4

7.8

538

3350

Z64.0

ICD-10 Finland

Problems related to unwanted pregnancy

2.4

7.7

205

N96

ICD-10 Finland

Habitual aborter

8.0

7.6

65006

ICD-8 Finland

Delivery without mention of complication, Complete or incomplete breech presentation

+∞

7.6

O46.8

ICD-10 Finland

Other antepartum haemorrhage

+∞

7.6

6510B

ICD-9 Finland

Multiple gestation, Twin pregnancy[GEMINI, SYNNYTYKSEN AIKANA]

+∞

7.6

O28.0

ICD-10 Finland

Abnormal haematological finding on antenatal screening of mother

+∞

7.6

LC2AE

SPAT

0.2

7.6

254

O22.4

ICD-10 Finland

Haemorrhoids in pregnancy

71.6

7.6

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.3

7.6

719

4696

Z12

ICPC

Relationship problem with partner

3.0

7.6

115

Z26.9

ICD-10 Finland

Need for immunization against unspecified infectious disease

0.2

7.5

331

R74

ICPC

Upper respiratory infection acute

1.3

7.5

855

5728

K04.08

ICD-10 Finland

Other specified pulpit

1.7

7.5

141

658

K04.00

ICD-10 Finland

Hyperemia of pulp

2.0

7.5

391

O66.2

ICD-10 Finland

Obstructed labour due to unusually large fetus

15.9

7.4

O33.4

ICD-10 Finland

Maternal care for disproportion of mixed maternal and fetal origin

15.9

7.4

WX110

NOMESCO Finland

Local anesthesy

1.3

7.4

1533

11110

R2130

SPAT

0.0

7.4

172

KAY60

NOMESCO Finland

0.4

7.4

559

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.3

7.4

1135

7907

SPAT1387

SPAT

Health survey during first study year, university level

0.4

7.2

518

Z87.1

ICD-10 Finland

Personal history of diseases of the digestive system

1.3

7.2

720

4732

O34.0

ICD-10 Finland

Maternal care for congenital malformation of uterus

26.5

7.2

Z37.2

ICD-10 Finland

Twins, both liveborn

26.5

7.2

6340A

ICD-9 Finland

Spontaneous abortion, Complicated by genital tract and pelvic infection

2.6

7.1

162

J01.0

ICD-10 Finland

Acute maxillary sinusitis

1.4

7.1

485

3011

W79

ICPC

Unwanted pregnancy

2.1

7.1

279

8811

FHL

Cesarean section

1.4

7.0

302

1727

S01GX02

ATC

levocabastine; ophthalmic

1.8

7.0

122

555

N97.8

ICD-10 Finland

Female infertility of other origin

3.0

6.9

103

O03

ICD-10 Finland

Spontaneous abortion

6.8

6.9

G01AF04

ATC

miconazole; vaginal

1.9

6.9

415

O66.4

ICD-10 Finland

Failed trial of labour, unspecified

35.8

6.9

O33.0

ICD-10 Finland

Maternal care for disproportion due to deformity of maternal pelvic bones

35.8

6.9

O16

ICD-10 Finland

Unspecified maternal hypertension

35.8

6.9

MBC33

NOMESCO Finland

Repair of complete rupture of perineum

35.8

6.9

WX290

NOMESCO Finland

Other blockade of nerve

1.3

6.9

1138

7970

Z48.0

ICD-10 Finland

Attention to surgical dressings and sutures

2.3

6.8

203

SPAT1281

SPAT

Other administrative function

1.7

6.8

154

760

SPAT1272

SPAT

Drug screening

6.5

6.7

O23.4

ICD-10 Finland

Unspecified infection of urinary tract in pregnancy

63.6

6.7

O89.4

ICD-10 Finland

Spinal and epidural anaesthesia-induced headache during the puerperium

63.6

6.7

O84.8

ICD-10 Finland

Other multiple delivery

+∞

6.7

O26.8

ICD-10 Finland

Other specified pregnancy-related conditions

+∞

6.7

O82.8

ICD-10 Finland

Other single delivery by caesarean section

+∞

6.7

O64.9

ICD-10 Finland

Obstructed labour due to malposition and malpresentation, unspecified

+∞

6.7

O86.4

ICD-10 Finland

Pyrexia of unknown origin following delivery

+∞

6.7

O32.8

ICD-10 Finland

Maternal care for other malpresentation of fetus

+∞

6.7

O32.4

ICD-10 Finland

Maternal care for high head at term

+∞

6.7

F53.9

ICD-10 Finland

Puerperal mental disorder, unspecified

+∞

6.7

SPAT1228

SPAT

Forms of educational rehabilitation therapy

14.6

6.7

MAA10

NOMESCO Finland

Biopsy of chorionic villus

14.6

6.7

G02BA03

ATC

plastic IUD with progestogen

1.6

6.6

174

890

K04.4

ICD-10 Finland

Acute apical periodontitis of pulpal origin

1.7

6.6

142

690

SPAT1394

SPAT

Counselling and guidance related to living conditions

4.5

6.5

IGY99

SPAT

0.2

6.5

229

P25

ICPC

Phase of life problem adult

1.8

6.5

106

475

LC2AE

NOMESCO Finland

Ultrasound examination of uterus and parametria

1.5

6.5

233

1283

SFA30

NOMESCO Finland

Filling on tree or more surfaces of tooth

1.3

6.4

652

4281

KMAK

NOMESCO Finland

1.3

6.4

1097

7688

WGA11

SPAT

0.1

6.4

175

O73.1

ICD-10 Finland

Retained portions of placenta and membranes, without haemorrhage

23.8

6.4

8221

FHL

Sterilization of the laparotomy pathway

0.2

6.3

272

O03.0

ICD-10 Finland

Spontaneous abortion, Incomplete, complicated by genital tract and pelvic infection

6.4

6.3

O68.9

ICD-10 Finland

Labour and delivery complicated by fetal stress, unspecified

15.9

6.3

SGA03

NOMESCO Finland

Demanding opening and dilatation of root canal of tooth

1.6

6.1

164

844

O36.4

ICD-10 Finland

Maternal care for intrauterine death

9.5

6.1

O20

ICD-10 Finland

Haemorrhage in early pregnancy

31.8

6.0

B01AB04

ATC

dalteparin; parenteral

2.2

6.0

197

NAME	O15_DELIV_CAESAR
CONTROL_EXCLUDE	O15_DELIVERY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O82
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O82
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
O15_DELIV_CAESAR	0.716 [0.63, 0.82]	< 0.001
Birth year	1.0 [0.99, 1.01]	0.965

N-year risk	Females	Males
1	0.078%	No data
5	0.457%	No data
10	1.188%	No data
15	2.209%	No data
20	3.953%	No data

Single delivery by caesarean section

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints