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Parkinson's disease, strict definition

PDSTRICT

secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G20
  • Hospital discharge: ICD-9 3320A
  • Hospital discharge: ICD-8 34200
  • Cause of death: ICD-10 G20
  • Cause of death: ICD-9 3320A
  • Cause of death: ICD-8 34200
  • KELA reimbursements: KELA codes 110
  • KELA reimbursements: ICD-10 G20, G20+F02.39

3 out of 7 registries used, show all original rules.

4840

4. Check minimum number of events

None

4840

5. Include endpoints

None

4840

6. Filter based on genotype QC (FinnGen only)

4692

Control definitions (FinnGen only)

Control exclude
G6_PARKINSON

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G20-G26
Name in latin
Morbus Parkinson

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 4692 1839 2853
Unadjusted period prevalence (%) 1.15 0.72 1.43
Median age at first event (years) 70.20 69.36 70.74

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
4838
Matched controls
48387
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N87
ICPC
Parkinsonism
274.7
323.0
1392
71
G20
ICD-10 Finland
Parkinson disease
12413.4
323.0
4644
46
193
Kela drug reimbursment
Rasagiline
+∞
323.0
708
*
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
15290.8
323.0
1176
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
+∞
323.0
3975
*
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
+∞
323.0
563
*
N04BC04
ATC
ropinirole; oral
234.3
323.0
1048
57
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
52.0
323.0
546
118
N04BC05
ATC
pramipexole; oral
15.1
323.0
1807
1834
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
632.6
323.0
3925
328
R25.1
ICD-10 Finland
Tremor, unspecified
21.9
323.0
888
491
N04BX02
ATC
entacapone; oral
2127.0
323.0
412
*
N04BC09
ATC
rotigotine; transdermal
226.5
323.0
357
17
N04BD01
ATC
selegiline; oral
810.1
323.0
1771
34
N06DA03
ATC
rivastigmine; oral, transdermal
8.5
323.0
800
1105
N04BD02
ATC
rasagiline; oral
5180.1
323.0
878
*
N05AH04
ATC
quetiapine; oral
4.2
260.8
1162
3391
AAG20
NOMESCO Finland
Stereotactic intracranial implantation of electrodes
682.4
200.7
197
*
N04BB01
ATC
amantadine; oral
16.0
196.0
328
219
N03AE01
ATC
clonazepam; systemic
5.4
185.7
611
1269
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
81.3
172.8
195
25
N04AA02
ATC
biperiden; systemic
13.6
170.0
304
237
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.2
150.6
640
1712
C07AA05
ATC
propranolol; systemic
2.9
148.5
1072
4311
AEA50
NOMESCO Finland
Adjustment of implanted neurostimulator
175.4
146.4
153
9
G04BD12
ATC
mirabegron; oral
3.1
142.2
902
3317
F02.39
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
1422.9
141.3
137
*
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
60.3
129.2
152
26
H02AA02
ATC
fludrocortisone; oral
14.9
120.3
206
144
3320A
ICD-9 Finland
Parkinson's disease, Paralysis agitans
+∞
118.2
113
*
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
90.2
110.6
123
14
G25.0
ICD-10 Finland
Essential tremor
6.1
107.6
311
541
R53
ICD-10 Finland
Malaise and fatigue
2.2
104.5
1272
6633
I95.1
ICD-10 Finland
Orthostatic hypotension
4.1
98.6
419
1103
AA1AD
NOMESCO Finland
CT of head and brain
2.0
96.1
1550
9067
N04BC02
ATC
pergolide; oral
166.6
93.5
98
6
A28
ICPC
Limited function/disability NOS
2.2
92.6
1164
6105
SPAT1229
SPAT
Assessment of need for aid
2.8
90.6
666
2630
XF606
NOMESCO Finland
Ortostatic test
13.4
90.2
161
124
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.1
88.1
545
1921
XA800
NOMESCO Finland
Neuropsychological investigation
5.1
86.8
290
598
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
85.4
1610
9902
A06AD11
ATC
lactulose; oral
2.2
85.4
1096
5770
N04BC06
ATC
cabergoline; oral (dopamine agonists)
28.6
81.8
112
40
L28
ICPC
Limited function/disability (L)
2.1
80.8
1086
5813
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
78.8
1721
11076
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
76.8
1072
5815
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.1
76.1
466
1626
N06AX11
ATC
mirtazapine; oral
1.9
75.8
1531
9555
SPAT1216
SPAT
Assessment of functional ability
2.1
73.1
1053
5768
AEA00
NOMESCO Finland
Replacement of impulse generator of stimulation device in the nervous system
30.0
71.8
97
33
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
7.7
70.1
168
224
G25.2
ICD-10 Finland
Other specified forms of tremor
16.6
68.9
112
69
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.0
67.7
434
1558
G23.1
ICD-10 Finland
Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
75.2
65.2
74
10
G02CB01
ATC
bromocriptine; systemic
12.0
63.9
119
101
R1250
NOMESCO Finland
Evaluation of functional capability
6.0
62.9
181
312
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.7
61.8
449
1742
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
61.4
845
4504
R4130
NOMESCO Finland
Speech therapy
4.9
60.6
207
436
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.4
59.6
306
935
N29
ICPC
Neurological sympt/complt other
5.4
58.7
184
352
N19
ICPC
Speech disorder
7.0
57.1
146
215
G21.8
ICD-10 Finland
Other secondary parkinsonism
53.0
56.9
68
13
N06AB10
ATC
escitalopram; oral
2.1
56.3
751
3937
F02.30
ICD-10 Finland
Dementia in Parkinson's disease without additional symptoms
554.2
55.7
55
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
54.0
1050
6332
N28
ICPC
Limited function/disability (N)
5.5
52.3
161
302
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
12.4
51.9
95
78
N05BA04
ATC
oxazepam; oral
1.8
51.7
1184
7516
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.4
51.0
476
2111
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
50.3
914
5364
D21
ICPC
Swallowing problem
5.5
49.4
151
281
SPAT1231
SPAT
Assessment of adjustments needed in living environment
4.0
48.8
207
540
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
48.0
809
4619
SPAT1234
SPAT
Support of social functional capacity
2.6
47.8
372
1496
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.3
46.4
454
2058
ZXM20
NOMESCO Finland
Intraoperative use of computerised tomography
11.5
46.0
87
77
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.4
45.7
432
1925
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.6
44.3
358
1468
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.1
44.1
545
2745
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.4
42.5
221
681
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.5
40.3
332
1373
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
3.8
40.1
178
483
F02.32
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly hallucinations
+∞
39.6
38
*
G90.3
ICD-10 Finland
Multi-system degeneration
58.0
39.3
46
8
Z2445
NOMESCO Finland
Psychologist
3.9
38.0
163
430
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.7
38.0
279
1083
U04
ICPC
Incontinence urine
2.5
37.7
306
1255
N03AX12
ATC
gabapentin; oral
1.8
37.7
740
4418
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
3.7
37.6
173
484
A04
ICPC
Weakness/tiredness general
1.9
37.6
666
3838
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
37.6
1410
10083
R47.1
ICD-10 Finland
Dysarthria and anarthria
5.9
36.6
104
178
S01.0
ICD-10 Finland
Open wound of scalp
2.1
36.2
441
2203
G25.8
ICD-10 Finland
Other specified extrapyramidal and movement disorders
3.6
34.7
163
465
R35
ICD-10 Finland
Polyuria
2.1
34.5
398
1940
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
10.8
34.0
66
62
N06AB04
ATC
citalopram; systemic
1.6
33.9
931
6119
K59.09
ICD-10 Finland
Constipation, unspecified
2.2
33.8
372
1774
M48.0
ICD-10 Finland
Spinal stenosis
1.7
32.9
704
4305
N05AH03
ATC
olanzapine; systemic
2.8
32.3
224
837
N30.0
ICD-10 Finland
Acute cystitis
1.8
32.0
655
3947
AA5QN
NOMESCO Finland
NA
88.2
31.7
35
*
S72.0
ICD-10 Finland
Fracture of neck of femur
2.3
30.9
296
1323
P20
ICPC
Memory disturbance
1.7
30.6
771
4936
N08
ICPC
Abnormal involuntary movements
17.3
30.5
48
28
M54.5
ICD-10 Finland
Low back pain
1.5
30.4
1264
9163
N04BX04
ATC
opicapone; oral
+∞
30.2
29
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.3
30.2
303
1382
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
3.5
30.1
147
433
130
Kela drug reimbursment
Malignant tumour
0.4
30.1
114
2889
R13
ICD-10 Finland
Dysphagia
2.1
30.0
367
1831
R60.0
ICD-10 Finland
Localized oedema
1.8
29.5
593
3548
N04AA01
ATC
trihexyphenidyl; oral
50.3
29.3
35
7
G23.8
ICD-10 Finland
Other specified degenerative diseases of basal ganglia
50.3
29.3
35
7
N04BC07
ATC
apomorphine; parenteral
+∞
29.2
28
*
34200
ICD-8 Finland
Paralysis agitans, Parkinsonismus
+∞
29.2
28
*
G04BD08
ATC
solifenacin; oral
2.0
29.1
399
2088
N99
ICPC
Neurological disease other
4.7
28.8
99
212
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.2
28.2
304
1434
F0230, G20
ICD-10 Finland
NA
+∞
27.1
26
*
F0232, G20
ICD-10 Finland
NA
+∞
27.1
26
*
SPAT1053
SPAT
Memory test
1.5
26.4
942
6564
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
3.7
26.4
119
330
K59.0
ICD-10 Finland
Constipation
2.1
26.3
323
1616
YX8AD
NOMESCO Finland
Stereotactic CT examination for dose design of radiotherapy
29.4
26.3
35
12
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
13.3
25.9
45
34
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.6
25.8
201
808
R2110
NOMESCO Finland
Giving the first information
2.2
25.6
272
1277
N05AX08
ATC
risperidone; systemic
1.9
25.5
398
2181
N03AG01
ATC
valproic acid; systemic, rectal
2.3
25.4
245
1098
N04BC01
ATC
bromocriptine; oral
39.0
24.8
31
8
N05AH02
ATC
clozapine; systemic
6.0
24.6
68
114
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
24.5
388
2136
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.6
24.3
699
4613
W19
ICD-10 Finland
Unspecified fall
1.8
24.1
462
2713
L03
ICPC
Low back symptom/complaint
1.5
24.0
936
6635
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
2.5
23.5
183
735
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
3.7
23.0
102
280
JDB10
NOMESCO Finland
Percutaneous gastrostomy
3.9
22.6
95
249
R1260
NOMESCO Finland
Evaluation of communicative skills
3.2
22.0
118
375
N04BX01
ATC
tolcapone; oral
+∞
21.9
21
*
R41.0
ICD-10 Finland
Disorientation, unspecified
2.3
21.9
205
907
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
4.9
21.5
71
147
Z75.5
ICD-10 Finland
Holiday relief care
3.8
21.3
92
247
N02BE01
ATC
paracetamol; systemic, rectal
1.4
21.3
3850
35464
N06AX16
ATC
venlafaxine; oral
1.8
21.2
398
2318
R55
ICD-10 Finland
Syncope and collapse
1.6
21.0
580
3776
R23
ICPC
Voice symptom/complaint
3.5
20.7
98
284
S06.0
ICD-10 Finland
Concussion
1.7
20.7
426
2553
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
20.7
1096
8239
AAW01
NOMESCO Finland
Implantation of intracranial stimulation device
110.5
20.6
22
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.8
20.4
350
1977
J01EA01
ATC
trimethoprim; systemic
1.4
20.1
1080
8133
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
4.7
20.0
69
150
SPAT1254
SPAT
Administration of medicine
1.5
19.9
715
4956
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
3.6
19.8
89
248
XKD00
NOMESCO Finland
Uroflowmetry
1.4
19.7
949
6995
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
19.5
383
2264
SPAT1301
SPAT
No procedures
1.4
19.3
1441
11476
R42
ICD-10 Finland
Dizziness and giddiness
1.4
19.1
1038
7821
N86
ICPC
Multiple sclerosis
7.4
19.1
45
61
H02AB02
ATC
dexamethasone; systemic
0.5
19.0
140
2803
R32
ICD-10 Finland
Unspecified urinary incontinence
2.5
18.7
153
634
TAB00
NOMESCO Finland
Lumbar puncture
2.4
18.6
161
685
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
3.3
18.4
92
280
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.7
18.3
428
2662
N06AX21
ATC
duloxetine; oral
1.7
18.2
368
2194
F06.0
ICD-10 Finland
Organic hallucinosis
11.4
17.9
33
29
R44.1
ICD-10 Finland
Visual hallucinations
6.0
17.9
49
82
G04BD09
ATC
trospium; oral
2.5
17.9
147
608
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
0.6
17.8
257
4261
N05BA06
ATC
lorazepam; systemic, sublingual
1.9
17.7
261
1398
S70.0
ICD-10 Finland
Contusion of hip
2.1
17.7
197
945
F02.31
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly paranoidism
+∞
17.7
17
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
1.6
17.6
445
2825
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
2.4
17.6
145
603
G04BD11
ATC
fesoterodine; oral
2.2
17.5
178
819
XKD06
NOMESCO Finland
Physiologic investigation of micturition
2.2
17.2
177
821
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
17.1
319
1853
G04CA02
ATC
tamsulosin; oral
1.3
17.0
1395
11233
K02.1
ICD-10 Finland
Caries of dentine
1.3
16.8
1862
15653
A03FA01
ATC
metoclopramide; systemic, rectal
0.7
16.8
435
6339
R60.9
ICD-10 Finland
Oedema, unspecified
2.0
16.7
227
1182
H50.52
ICD-10 Finland
Exophoria
5.0
16.6
53
107
J01CA08
ATC
pivmecillinam; oral
1.3
16.6
1323
10594
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.4
16.6
742
5374
F02.34
ICD-10 Finland
Dementia in Parkinson's disease, other additional symptoms of mixed type
170.5
16.5
17
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.5
16.0
709
5120
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
6.4
15.9
41
64
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
3.2
15.8
82
257
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
15.8
1765
14824
F02.3
ICD-10 Finland
Dementia in Parkinson disease
160.5
15.5
16
*
N06AX03
ATC
mianserin; oral
1.9
15.3
222
1183
G04BD04
ATC
oxybutynin; oral, transdermal
1.7
15.3
296
1741
Z29
ICPC
Social problem NOS
2.9
15.3
91
315
G04BD07
ATC
tolterodine; oral
1.8
15.0
270
1552
N40
ICD-10 Finland
Hyperplasia of prostate
1.3
14.8
1302
10545
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.1
14.8
169
824
P29
ICPC
Psychological sympt/compl other
2.3
14.7
135
595
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.6
14.6
413
2698
G23.2
ICD-10 Finland
Multiple system atrophy, parkinsonian type [MSA-P]
80.3
14.6
16
*
N87
ICD-10 Finland
Dysplasia of cervix uteri
80.3
14.6
16
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.0
14.5
181
914
M03BX01
ATC
baclofen; systemic
3.1
14.5
78
252
SPAT1050
SPAT
Extensive neurological examination
2.5
14.3
113
462
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
4.0
14.3
57
145
C01CA01
ATC
etilefrine; systemic
3.6
14.2
63
176
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
14.2
553
3888
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
3.3
14.1
69
208
AA1AA
NOMESCO Finland
Head X-ray examination
3.8
14.1
59
157
N30.9
ICD-10 Finland
Cystitis, unspecified
1.8
13.7
248
1428
I95.9
ICD-10 Finland
Hypotension, unspecified
2.7
13.6
94
358
F023, G20
ICD-10 Finland
NA
+∞
13.5
13
*
F0234, G20
ICD-10 Finland
NA
+∞
13.5
13
*
RF120
NOMESCO Finland
NA
3.4
13.5
65
194
E86
ICD-10 Finland
Volume depletion
2.2
13.3
139
652
H50.31
ICD-10 Finland
Intermittent exotropia
5.4
13.2
39
73
Z50.1
ICD-10 Finland
Other physical therapy
1.8
13.1
241
1398
R5110
SPAT
NA
2.2
13.1
133
618
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
0.3
12.8
33
987
SPAT1167
SPAT
Insertion of urinary catheter
1.9
12.8
201
1106
Z50.5
ICD-10 Finland
Speech therapy
3.3
12.8
62
187
K11.72
ICD-10 Finland
Xerostomia
14.1
12.7
21
15
M04AA01
ATC
allopurinol; systemic
0.7
12.7
383
5444
L17
ICPC
Foot/toe symptom/complaint
1.3
12.6
993
7883
WF049
NOMESCO Finland
Radiotherapy of metastasis
0.3
12.6
27
881
R44.3
ICD-10 Finland
Hallucinations, unspecified
5.7
12.5
35
62
C03CA01
ATC
furosemide; systemic
1.3
12.5
1690
14425
M41.9
ICD-10 Finland
Scoliosis, unspecified
3.2
12.3
64
203
G35
ICD-10 Finland
Multiple sclerosis
3.8
12.3
50
131
K08.3
ICD-10 Finland
Retained dental root
1.7
12.1
281
1742
F05.9
ICD-10 Finland
Delirium, unspecified
2.2
12.1
118
538
SPAT1240
SPAT
Therapeutic discussion
1.7
12.1
247
1477
S00.0
ICD-10 Finland
Superficial injury of scalp
2.4
12.0
101
430
AA1BD
NOMESCO Finland
Extensive CT of head and brain
2.1
12.0
127
601
N05BA01
ATC
diazepam; systemic, rectal
1.4
12.0
542
3919
Z01.8
ICD-10 Finland
Other specified special examinations
1.3
11.9
823
6402
M41.4
ICD-10 Finland
Neuromuscular scoliosis
46.8
11.9
14
*
R4110
SPAT
NA
2.2
11.8
121
562
UDQ42
NOMESCO Finland
Endoscopic assessment of swallowing function
8.4
11.8
25
30
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
0.3
11.7
26
829
S01.9
ICD-10 Finland
Open wound of head, part unspecified
2.7
11.7
79
299
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.5
11.6
373
2510
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
1.9
11.6
156
814
G24.9
ICD-10 Finland
Dystonia, unspecified
7.7
11.6
26
34
RF420
NOMESCO Finland
NA
3.0
11.6
64
213
L89
ICD-10 Finland
Decubitus ulcer and pressure area
2.3
11.6
104
457
AAG99
NOMESCO Finland
Other stereotactic intracranial operation
+∞
11.5
11
*
359
Kela drug reimbursment
Mirabegroni
3.9
11.4
45
115
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
2.3
11.4
103
454
UKC02
NOMESCO Finland
Cystoscopy
1.3
11.4
862
6796
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
3.2
11.3
58
184
L84
ICD-10 Finland
Corns and callosities
2.0
11.1
147
762
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
3.7
11.0
46
124
D12
ICPC
Constipation
1.9
11.0
159
854
WYA20
NOMESCO Finland
Home visit
2.4
10.9
90
377
N03AX09
ATC
lamotrigine; oral
2.2
10.9
107
489
H02AB06
ATC
prednisolone; systemic
0.8
10.9
1489
17228
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
1.7
10.9
232
1406
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
4.9
10.8
34
70
WX290
NOMESCO Finland
Other blockade of nerve
1.3
10.8
1175
9729
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
2.3
10.6
100
449
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
10.5
1746
15177
S01.8
ICD-10 Finland
Open wound of other parts of head
2.8
10.5
66
239
SPAT1172
SPAT
Guidance concerning hydration
2.0
10.5
132
673
Z02.4
ICD-10 Finland
Examination for driving licence
0.8
10.4
819
10100
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
2.2
10.4
106
494
S22.3
ICD-10 Finland
Fracture of rib
1.6
10.4
279
1801
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
1.7
10.4
234
1441
F29
ICD-10 Finland
Unspecified nonorganic psychosis
2.5
10.4
77
307
Z3226
NOMESCO Finland
Physiotherapist
1.3
10.3
742
5798
A29
ICPC
General symptom/complaint other
1.4
10.3
467
3375
R63.4
ICD-10 Finland
Abnormal weight loss
1.9
10.3
155
843
N05AX12
ATC
aripiprazole; systemic
2.8
10.2
65
237
R30.1
ICD-10 Finland
Vesical tenesmus
2.4
10.2
83
347
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
0.1
10.2
6
415
G72.8
ICD-10 Finland
Other specified myopathies
2.4
10.2
80
330
R29.6
ICD-10 Finland
Tendency to fall, not elsewhere classified
5.0
10.1
31
62
NA1AD
NOMESCO Finland
Cervical spine CT examination
1.8
10.1
161
894
N05AN01
ATC
lithium; oral
2.6
10.1
72
282
A06AX04
ATC
linaclotide; oral
8.4
10.0
21
25
G21.2
ICD-10 Finland
Secondary parkinsonism due to other external agents
40.1
10.0
12
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
2.8
9.9
62
222
W06
ICD-10 Finland
Fall involving bed
3.2
9.9
49
152
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
0.4
9.8
37
936
P03
ICPC
Feeling depressed
1.8
9.8
177
1024
JX1LA
NOMESCO Finland
Kinetic X-ray of alimentary tract with pictures
10.6
9.8
18
17
Z02.7
ICD-10 Finland
Issue of medical certificate
1.6
9.8
236
1485
SPAT1262
SPAT
Handing over of treatment supplies
1.3
9.7
812
6477
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
2.6
9.7
70
276
EBA00
NOMESCO Finland
Extraction of tooth
1.3
9.7
1122
9338
N06DA02
ATC
donepezil; oral
1.5
9.7
306
2055
R33
ICD-10 Finland
Retention of urine
1.4
9.6
436
3153
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
2.6
9.6
66
254
S20.2
ICD-10 Finland
Contusion of thorax
1.7
9.6
184
1086
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.3
9.5
622
4783
X59
ICD-10 Finland
Exposure to unspecified factor
1.3
9.5
628
4840
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
3.5
9.5
43
125
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.9
9.5
37
95
N05AB03
ATC
perphenazine; systemic, rectal
2.0
9.5
122
628
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.3
9.5
854
6882
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
2.2
9.4
87
391
G23.3
ICD-10 Finland
Multiple system atrophy, cerebellar type [MSA-C]
+∞
9.4
9
*
Z60.8
ICD-10 Finland
Other problems related to social environment
5.8
9.3
25
43
XKC03
NOMESCO Finland
Water cystometry
1.9
9.3
133
712
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
3.8
9.3
37
97
F06.2
ICD-10 Finland
Organic delusional [schizophrenia-like] disorder
8.7
9.3
19
22
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.6
9.3
253
1643
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
0.4
9.2
31
821
RF410
NOMESCO Finland
NA
2.9
9.2
53
182
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
3.0
9.2
50
167
Z11
ICPC
Compliance/being ill problem
3.7
9.2
38
103
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
9.1
2044
18240
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
1.4
9.0
435
3178
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.2
9.0
91
423
SPAT1293
SPAT
Other function in accordance with rehabilitation guidance nomenclature
3.9
9.0
35
90
Y94.0
ICD-10 Finland
Accident at home
2.2
9.0
91
425
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.3
9.0
658
5152
N06AX26
ATC
vortioxetine; oral
1.9
9.0
131
709
SPAT1244
SPAT
Occupational therapy
2.7
9.0
57
209
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
4.8
9.0
28
58
N05CD07
ATC
temazepam; oral
1.3
8.9
611
4732
H53.2
ICD-10 Finland
Diplopia
1.9
8.9
126
672
L01BC06
ATC
capecitabine; oral
0.4
8.9
34
852
L29
ICPC
Musculoskeletal sympt/complt other
1.5
8.8
278
1865
K07
ICPC
Swollen ankles/oedema
1.6
8.8
207
1294
M79.6
ICD-10 Finland
Pain in limb
1.2
8.7
1307
11184
SPAT1101
SPAT
Orthostatic test
1.6
8.7
231
1491
K88
ICPC
Postural hypotension
2.9
8.7
51
179
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.8
8.7
147
836
N03AA03
ATC
primidone; oral
5.8
8.6
23
40
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
3.0
8.6
49
167
P01
ICPC
Feeling anxious/nervous/tense
1.7
8.5
162
955
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
4.4
8.5
29
66
G22
ICD-10 Finland
Parkinsonism in diseases classified elsewhere
90.2
8.4
9
*
SCA03
NOMESCO Finland
Preventive oral health care, extensive
1.9
8.4
120
645
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
2.3
8.4
74
326
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
1.3
8.4
624
4894
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
2.6
8.4
57
217
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
4.2
8.4
30
72
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.3
8.3
557
4299
G40.9
ICD-10 Finland
Epilepsy, unspecified
1.8
8.3
131
729
RF433
NOMESCO Finland
NA
10.7
8.3
15
14
R03BB04
ATC
tiotropium bromide; inhalant
0.7
8.2
264
3718
C34.10
ICD-10 Finland
Malignant tumor of the upper lobe, bronchus or lung without histology
0.1
8.2
*
264
K03.66
ICD-10 Finland
Tooth plaque
1.6
8.2
207
1321
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.4
8.2
396
2898
S01.41
ICD-10 Finland
Open wound in the temple-jaw region
2.8
8.2
49
175
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.3
8.2
638
5035
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.7
8.2
164
984
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
0.7
8.2
252
3573
183
Kela drug reimbursment
Lamotrigin and topiramate
4.1
8.1
30
74
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.4
8.1
431
3203
U07
ICPC
Urine symptom/complaint other
1.5
8.1
234
1541
H02.3
ICD-10 Finland
Blepharochalasis
1.5
8.1
249
1664
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.4
8.1
454
3408
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.4
8.1
388
2836
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
1.5
8.1
259
1745
N03AF02
ATC
oxcarbazepine; oral
1.9
8.1
109
574
EBA30
NOMESCO Finland
Excision of root of tooth
1.6
8.1
207
1325
G04CB02
ATC
dutasteride; oral
1.4
8.0
360
2600
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
2.3
8.0
71
312
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
1.7
8.0
159
951
WF002
NOMESCO Finland
Radical radiotherapy
0.6
8.0
86
1536
R26
ICD-10 Finland
Abnormalities of gait and mobility
5.2
8.0
23
44
N03AX16
ATC
pregabalin; oral
1.3
7.9
877
7238
M40.1
ICD-10 Finland
Other secondary kyphosis
7.2
7.9
18
25
SPAT1294
SPAT
Other function in accordance with health social work nomenclature
1.9
7.9
106
559
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
1.6
7.9
194
1230
L02
ICPC
Back symptom/complaint
1.5
7.9
258
1750
SPAT1263
SPAT
Sampling
1.2
7.8
1680
14864
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.4
7.8
61
251
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
2.1
7.8
86
420
SPAT1360
SPAT
Extensive global examination
1.4
7.8
317
2247
JN4BD
NOMESCO Finland
Extensive body CT
0.7
7.8
273
3782
F22.0
ICD-10 Finland
Delusional disorder
2.4
7.7
60
247
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.5
7.6
281
1952
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
1.7
7.6
145
857
AXX01
NOMESCO Finland
Memory assessment
18.4
7.6
11
6
N04AB02
ATC
orphenadrine (chloride); systemic
25.0
7.6
10
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.2
7.6
1141
9748
G25
ICD-10 Finland
Other extrapyramidal and movement disorders
8.8
7.5
15
17
G25.1
ICD-10 Finland
Drug-induced tremor
6.1
7.5
19
31
T36
ICD-10 Finland
Poisoning by systemic antibiotics
1.9
7.5
99
519
F20.9
ICD-10 Finland
Schizophrenia, unspecified
2.6
7.5
53
209
S01
ICD-10 Finland
Open wound of head
2.5
7.5
54
216
R25.8
ICD-10 Finland
Other and unspecified abnormal involuntary movements
5.7
7.5
20
35
N17
ICPC
Vertigo/dizziness
1.3
7.5
454
3451
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.7
7.5
147
876
B03BA03
ATC
hydroxocobalamin; parenteral
1.4
7.4
290
2039
WX110
NOMESCO Finland
Local anesthesy
1.2
7.4
2438
22363
IGY02
NOMESCO Finland
Psychiatric monitoring contact
3.0
7.3
40
136
N04C02
ATC
NA
+∞
7.3
7
*
G81.9
ICD-10 Finland
Hemiplegia, unspecified
2.5
7.3
52
207
R39.1
ICD-10 Finland
Other difficulties with micturition
1.7
7.3
133
777
RF210
NOMESCO Finland
NA
1.9
7.3
99
525
SPAT1304
SPAT
Counselling and guidance related to ageing
1.4
7.3
363
2672
G04CA52
ATC
tamsulosin and dutasteride; systemic
1.3
7.3
512
3981
N06AB06
ATC
sertraline; oral
1.5
7.2
275
1926
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.4
7.2
406
3048
J01MA02
ATC
ciprofloxacin; systemic
1.2
7.2
1682
14968
A08
ICPC
Swelling
1.6
7.2
176
1116
M47.9
ICD-10 Finland
Spondylosis, unspecified
1.7
7.2
132
772
N02CA01
ATC
dihydroergotamine; nasal, systemic
4.1
7.2
26
64
N02AA05
ATC
oxycodone; systemic
1.3
7.1
675
5460
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
0.4
7.1
35
796
AA400
NOMESCO Finland
Electroconvulsive therapy
3.6
7.1
30
84
AA052
NOMESCO Finland
NA
20.0
7.1
10
5
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
3.0
7.1
37
122
A03FA02
ATC
cisapride; oral, rectal
1.4
7.1
336
2451
G21.0
ICD-10 Finland
Malignant neuroleptic syndrome
12.0
7.1
12
10
Z43.1
ICD-10 Finland
Attention to gastrostomy
8.8
7.0
14
16
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.3
7.0
522
4091
C10AA07
ATC
rosuvastatin; oral
0.8
7.0
696
8396
L76
ICPC
Fracture: other
1.8
7.0
114
643
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
0.6
7.0
94
1585
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
1.9
7.0
92
480
S00.1
ICD-10 Finland
Contusion of eyelid and periocular area
2.2
7.0
65
296
NE1AA
NOMESCO Finland
Pelvis X-ray examination
1.4
7.0
291
2076
R21
NOMESCO Finland
Counselling and guidance in rehabilitation
2.7
6.9
43
159
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
1.8
6.9
117
669
SPAT1104
SPAT
Monitoring of emergency patient
1.4
6.9
265
1861
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.4
6.9
364
2708
C10AX09
ATC
ezetimibe; oral
0.7
6.8
250
3442
NF1AA
NOMESCO Finland
Hip X-ray examination
1.4
6.8
375
2808
M43.1
ICD-10 Finland
Spondylolisthesis
1.7
6.8
129
764
SPAT1260
SPAT
Consultation of another employee
1.3
6.8
689
5628
3321A
ICD-9 Finland
Parkinson's disease, Secondary Parkinsonism
40.1
6.8
8
*
ZXY02
NOMESCO Finland
Neuropsychologist
4.5
6.8
22
49
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
3.1
6.7
34
110
A01
ICPC
Pain general/multiple sites
1.4
6.7
278
1978
N05AA02
ATC
levomepromazine; systemic
1.7
6.7
140
852
N05AF03
ATC
chlorprothixene; systemic
2.0
6.7
77
383
K56.2
ICD-10 Finland
Volvulus
2.8
6.7
39
138
U02
ICPC
Urinary frequency/urgency
1.3
6.7
452
3498
K90
ICPC
Stroke/cerebrovascular accident
1.7
6.6
137
829
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
1.5
6.6
247
1724
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.3
6.6
721
5936
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
0.7
6.6
149
2233
G24.3
ICD-10 Finland
Spasmodic torticollis
3.2
6.6
31
96
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
0.6
6.6
71
1260
8000/3-C34.9
ICD-O-3
Neoplasm, malignant of lung, NOS
0.2
6.6
7
329
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
1.9
6.5
90
480
A04AA02
ATC
granisetron; systemic, transdermal
0.6
6.5
84
1424
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
1.9
6.5
92
495
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
6.2
6.5
16
26
SPAT1139
SPAT
Nutrition survey
1.7
6.4
130
783
S40.0
ICD-10 Finland
Contusion of shoulder and upper arm
1.7
6.4
125
746
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.1
6.4
66
315
G21
ICD-10 Finland
Secondary parkinsonism
69.9
6.4
7
*
3010
Kela drug reimbursment
Midodrine
69.9
6.4
7
*
M01AC06
ATC
meloxicam; systemic, rectal
1.2
6.4
1328
11665
RF214
NOMESCO Finland
NA
7.4
6.4
14
19
WZA10
NOMESCO Finland
Long statement of health and health related matters
2.6
6.4
42
161
S01.3
ICD-10 Finland
Open wound of ear
2.4
6.3
47
193
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
4.9
6.3
19
39
TJD10
NOMESCO Finland
Insertion of other tube into stomach or duodenum
6.5
6.3
15
23
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
6.3
1762
15876
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.4
6.3
317
2339
F25.01
ICD-10 Finland
Schizoaffective syndrome, manic type with prolonged schizophrenic than bipolar symptoms
9.2
6.3
12
13
TKC22
NOMESCO Finland
Catheterisation instruction
1.8
6.3
104
592
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
3.0
6.2
33
111
F02.33
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly depression
+∞
6.2
6
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.2
6.2
856
7228
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
2.3
6.2
54
240
U05
ICPC
Urination problems other
1.5
6.2
201
1365
R43.0
ICD-10 Finland
Anosmia
3.2
6.2
29
90
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
0.7
6.2
146
2170
N05BA12
ATC
alprazolam; oral
1.4
6.1
337
2522
R4110
NOMESCO Finland
Physiotherapy
1.2
6.1
1024
8811
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
1.4
6.1
326
2431
3AX01
NOMESCO Finland
NA
4.6
6.1
19
41
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.3
6.1
423
3283
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
1.8
6.1
100
566
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.6
6.1
143
900
TJD20
NOMESCO Finland
Change of gastrostomy tube
3.7
6.1
24
65
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
3.0
6.1
32
108
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.5
6.0
220
1531
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.2
6.0
1200
10494
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
1.8
6.0
90
494

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: PDSTRICT – Parkinson's disease, strict definition

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).