No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2525 |
4. Check minimum number of eventsNone |
2525 |
5. Include endpointsNone |
2525 |
6. Filter based on genotype QC (FinnGen only) |
2525 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Septal defects
based on the number of shared cases.
Similar with more cases:
- Congenital malformations of heart and great arteries
- Congenital malformations, deformations and chromosomal abnormalities
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 37758 | 20128 | 17561 |
| Only index persons | 24425 | 13039 | 11386 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.54 | 0.58 | 0.49 |
| Only index persons | 0.46 | 0.48 | 0.43 |
| Median age at first event (years) | |||
| Whole population | 0.53 | 0.50 | 0.42 |
| Only index persons | 3.90 | 4.73 | 2.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2525 | 1500 | 1025 |
| Unadjusted period prevalence (%) | 0.49 | 0.51 | 0.45 |
| Median age at first event (years) | 38.10 | 34.81 | 42.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2271
- Matched controls
- 22141
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q21.19
ICD-10 Finland
Atrial septal defect NOS
4395.1
323.0
388
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
7.1
323.0
1028
2295
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
26.6
323.0
865
500
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
733.6
323.0
324
5
Q21.10
ICD-10 Finland
Persistent ostium secundum
5116.1
323.0
747
*
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
+∞
323.0
323
*
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
+∞
323.0
458
*
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
+∞
323.0
314
*
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
4640.7
323.0
699
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
7.1
277.1
801
1582
XF620
NOMESCO Finland
Examination of circulation with color method
179.1
235.8
246
15
B01AA03
ATC
warfarin; systemic
5.5
184.9
632
1439
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
12.2
172.0
330
305
XF400
NOMESCO Finland
ECG with 12 standard connections
4.4
157.3
695
2030
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
7.5
155.6
400
613
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
20.9
153.3
234
121
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
326.8
153.3
155
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
147.1
1168
5451
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
8.7
135.0
310
393
31
HP
Congenital heart failure surgery
273.5
129.3
132
5
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
119.8
115
*
XF404
NOMESCO Finland
Ambulatory ECG
5.3
118.9
401
856
201
Kela drug reimbursment
Chronic cardiac insufficiency
10.0
118.8
250
270
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
+∞
110.3
106
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.0
103.7
370
832
Q21.0
ICD-10 Finland
Ventricular septal defect
502.1
99.3
99
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
18.7
97.6
154
86
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
321.4
92.7
94
*
FFC42
NOMESCO Finland
Percutaneous closure of patent foramen ovale
901.2
90.6
89
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
3.4
83.2
463
1539
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
+∞
83.1
80
*
FM2CE
NOMESCO Finland
NA
7.0
81.3
212
319
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.1
74.1
465
1674
C03CA01
ATC
furosemide; systemic
2.9
72.9
530
2103
5205
FHL
ASD blockage, secondary defect
712.6
71.8
71
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.4
70.9
280
685
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.1
69.8
457
1687
C01AA05
ATC
digoxin; systemic
5.7
67.8
208
386
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
6.6
67.3
182
287
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
65.7
785
4081
PA2AE
NOMESCO Finland
Ultrasound examination of brain artery
323.0
64.1
65
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
11.9
64.1
121
104
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
317.8
63.1
64
*
Q25.0
ICD-10 Finland
Patent ductus arteriosus
16.4
59.1
97
60
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
59.1
57
*
XF402
NOMESCO Finland
ECG with work load test
3.5
58.7
300
914
62
HP
Catheterization and pressure measurement of the right side of the heart
44.6
57.2
71
16
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
56.9
329
1100
Q25.1
ICD-10 Finland
Coarctation of aorta
23.6
56.7
82
35
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
53.9
52
*
AA1AD
NOMESCO Finland
CT of head and brain
2.5
53.5
503
2271
TFP20
NOMESCO Finland
Cardiodefibrillation
4.5
53.2
203
476
C07AB07
ATC
bisoprolol; oral
2.1
52.6
827
4754
C03DA01
ATC
spironolactone; oral
3.6
52.4
255
744
61
HP
Catheterization and pressure measurement of the left side of the heart
14.2
51.9
90
64
5253
FHL
Cardiac lung machine
38.3
50.9
65
17
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
5.0
49.2
166
342
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
4.4
48.2
188
449
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
48.1
615
3205
WX892
NOMESCO Finland
Monitored bed care
3.4
48.1
259
817
B01AC04
ATC
clopidogrel; oral
3.0
47.6
299
1053
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
6.0
47.2
137
236
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.2
47.1
269
885
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
37.5
46.8
60
16
XA800
NOMESCO Finland
Neuropsychological investigation
3.5
46.5
236
710
FFC50
NOMESCO Finland
Closure of ostium secundum type ASD using patch
+∞
45.5
44
*
APK
HP
ASD closure
+∞
45.5
44
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
8.4
45.3
103
125
Q23.11
ICD-10 Finland
Bicuspid aortic valve
12.6
43.9
80
64
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
5.6
43.5
132
240
Q21.1
ICD-10 Finland
Atrial septal defect
+∞
43.5
42
*
Q21.20
ICD-10 Finland
Atrial septal defect of primum type
424.8
42.9
43
*
207
Kela drug reimbursment
Chronic arrhythmias
3.0
41.8
270
964
APJ
HP
PFO closure
+∞
41.4
40
*
5207
FHL
VSD closure
+∞
41.4
40
*
TPX22
NOMESCO Finland
Intravenous arterial thrombolysis
18.1
41.4
65
36
XF600
NOMESCO Finland
Bloodpressure measurement
3.0
41.3
260
913
WX872
NOMESCO Finland
Intensive care
4.3
40.5
157
372
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
44.3
39.7
49
11
AF1
HP
Surgery of congenital heart defect
203.4
39.6
41
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
4.1
38.3
157
393
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
10.9
38.0
74
68
I50.9
ICD-10 Finland
Heart failure, unspecified
3.2
37.8
217
711
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
132.2
37.4
40
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.4
37.3
142
331
XF622
NOMESCO Finland
Measurement of minute volume of heart
17.8
36.2
57
32
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
5.9
35.6
103
177
7456A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Endocardial cushion defects[DEFECTUS SEPTI ATRIORUM NUD]
+∞
35.2
34
*
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
11.8
34.8
65
55
Q20.1
ICD-10 Finland
Double outlet right ventricle
173.2
33.5
35
*
Q21.12
ICD-10 Finland
Defective sinus venosus
+∞
33.1
32
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
33.0
501
2740
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
7.6
32.9
79
105
XF640
NOMESCO Finland
NA
6.2
32.3
89
144
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
32.2
458
2435
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
15.2
31.2
52
34
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
31.0
247
995
K78
ICPC
Atrial fibrillation/flutter
3.5
31.0
152
443
R4150
NOMESCO Finland
Neuropsychological rehabilitation
10.0
30.6
62
62
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
5.0
30.0
100
203
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
15.1
29.9
50
33
Q21.21
ICD-10 Finland
Atrioventricular duct
49.4
29.1
35
7
I34.1
ICD-10 Finland
Mitral (valve) prolapse
5.5
28.8
87
158
B01AB05
ATC
enoxaparin; parenteral
1.9
28.6
529
3089
R4110
NOMESCO Finland
Physiotherapy
1.8
28.6
604
3694
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
27.9
27
*
I49.5
ICD-10 Finland
Sick sinus syndrome
5.3
27.4
85
160
WX882
NOMESCO Finland
High dependency care
2.9
27.1
176
626
WX402
NOMESCO Finland
General anaesthesia
1.9
26.4
434
2423
C01BD01
ATC
amiodarone; systemic
5.8
26.3
76
131
C10AA05
ATC
atorvastatin; oral
1.8
25.6
565
3485
K90
ICPC
Stroke/cerebrovascular accident
5.7
25.4
74
129
R4120
NOMESCO Finland
Occupational therapy
2.6
25.3
195
771
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.4
25.2
224
956
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.4
24.1
123
370
Q21.30
ICD-10 Finland
Tetralogy of Fallot
19.8
24.0
36
18
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
5.4
23.5
72
134
Q26.3
ICD-10 Finland
Partial anomalous pulmonary venous connection
85.5
23.4
26
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
6.6
23.0
60
91
AA5PD
NOMESCO Finland
CT examination of brain pefusion
11.2
22.8
43
38
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
11.6
22.6
42
36
C07AA07
ATC
sotalol; systemic
4.6
22.4
80
176
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
39.5
22.4
28
7
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
22.4
253
1207
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
2.4
22.3
193
810
I37.0
ICD-10 Finland
Pulmonary valve stenosis
44.3
22.1
27
6
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
5.9
22.1
62
104
C09AA05
ATC
ramipril; oral
1.9
22.0
359
1986
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
4.6
21.9
78
171
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
21.9
367
2052
Q26.1
ICD-10 Finland
Persistent left superior vena cava
42.7
21.2
26
6
I50.0
ICD-10 Finland
Congestive heart failure
3.3
21.0
109
333
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
21.0
457
2784
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
5.4
21.0
64
119
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
75.6
20.5
23
*
Q21.29
ICD-10 Finland
Atrioventricular septal defect UNS
+∞
19.6
19
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
15.1
19.4
32
21
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.3
19.3
188
837
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
24.2
19.3
27
11
AP3
HP
Catheterization of the right and left side of the heart
21.2
19.2
28
13
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.5
18.9
90
258
R06.0
ICD-10 Finland
Dyspnoea
1.7
18.7
446
2779
R42
ICD-10 Finland
Dizziness and giddiness
1.8
18.7
369
2170
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
33.8
18.7
24
7
74646
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium primum
+∞
18.6
18
*
FFC32
NOMESCO Finland
Percutaneous transluminal closure of sinus venosus type ASD
+∞
18.6
18
*
Q21.80
ICD-10 Finland
Communication from left ventricle to right atrium
+∞
18.6
18
*
Q20.48
ICD-10 Finland
Single ventricle
27.4
18.5
25
9
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
13.2
18.4
32
24
AP2
HP
Catheterization of the right side of the heart
18.4
18.4
28
15
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
5.0
18.3
59
117
C07AB02
ATC
metoprolol; systemic
1.9
18.3
307
1708
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.9
18.1
76
196
I63
ICD-10 Finland
Cerebral infarction
10.8
17.9
34
31
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
3.5
17.8
84
239
G04BE03
ATC
sildenafil; oral
5.8
17.7
50
85
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.1
17.6
217
1073
90492
NOMESCO Finland
NA
93.4
17.4
19
*
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
93.4
17.4
19
*
PA7CD
NOMESCO Finland
CT angiography of neck and brain, extensive
7.2
17.4
42
58
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.2
17.1
91
285
602
Kela drug reimbursment
Children's severe malnutrition
3.8
16.9
71
184
J01CA04
ATC
amoxicillin; systemic
1.6
16.9
1873
16515
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
9.1
16.8
35
38
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
13.0
16.7
29
22
TFP34
NOMESCO Finland
Electrophysiological investigation
3.6
16.7
76
211
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.2
16.6
90
286
FFC40
NOMESCO Finland
Closure of Patent Foramen Ovale
+∞
16.5
16
*
Q90.9
ICD-10 Finland
Down syndrome, unspecified
27.0
16.3
22
8
Z98.8
ICD-10 Finland
Other specified postsurgical states
5.1
16.2
51
99
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
16.2
329
1945
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.6
16.0
124
490
RS224
NOMESCO Finland
NA
5.2
15.9
49
93
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
18.2
15.8
24
13
B01AF02
ATC
apixaban; oral
2.3
15.7
143
617
Q22.0
ICD-10 Finland
Pulmonary valve atresia
58.9
15.6
18
*
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
32.8
15.5
20
6
XX3BT
NOMESCO Finland
Other labeling with X-ray guidance
5.1
15.5
49
96
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
4.2
15.5
59
140
7454X
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[VSD ALIA DEFINITA]
+∞
15.5
15
*
K84
ICPC
Heart disease other
4.2
15.4
58
136
FFC96
NOMESCO Finland
Other closure of isolated atrial septal defect
157.0
15.3
16
*
R04.0
ICD-10 Finland
Epistaxis
2.4
15.3
135
572
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.0
15.3
91
308
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
13.5
15.2
26
19
I47.1
ICD-10 Finland
Supraventricular tachycardia
2.7
15.0
104
385
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
28.1
15.0
20
7
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
7.5
14.6
34
45
FM1CD
NOMESCO Finland
Very extensive CT of heart
18.0
14.5
22
12
Q21.81
ICD-10 Finland
Eisenmenger's syndrome
+∞
14.5
14
*
Q21.88
ICD-10 Finland
Other congenital malformations of cardiac septa
+∞
14.5
14
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
14.4
187
943
WX704
NOMESCO Finland
Intubation
2.2
14.3
151
697
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
12.3
14.1
25
20
I27.0
ICD-10 Finland
Primary pulmonary hypertension
15.5
13.7
22
14
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
6.7
13.6
34
50
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.0
13.6
189
981
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
11.2
13.5
25
22
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.5
13.5
578
4124
AN1
HP
Coronary angiography
2.1
13.4
163
799
7470A
ICD-9 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
73.7
13.4
15
*
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
14.4
13.4
22
15
Q20.40
ICD-10 Finland
Double inlet left ventricle
137.3
13.3
14
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
137.3
13.3
14
*
FHB00
NOMESCO Finland
Transatrial suture of VSD
137.3
13.3
14
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
13.2
371
2395
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
9.2
13.2
27
29
Q87.14
ICD-10 Finland
Noonan's syndrome
25.2
13.2
18
7
Q25.40
ICD-10 Finland
Aortic hypoplasia
17.9
13.2
20
11
R62.0
ICD-10 Finland
Delayed milestone
2.8
13.1
82
288
81
HP
Angiography of the heart and coronary arteries
2.8
13.1
86
311
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
10.3
13.0
25
24
ZSF00
NOMESCO Finland
Procedure related to previous procedure classified in chapter F
39.2
13.0
16
*
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
39.2
13.0
16
*
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
6.5
13.0
33
50
Q90.0
ICD-10 Finland
Trisomy 21, meiotic nondisjunction
22.1
12.7
18
8
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
12.7
888
6955
H53.4
ICD-10 Finland
Visual field defects
3.7
12.7
55
148
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
49.0
12.7
15
*
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
6.8
12.6
31
45
R1260
NOMESCO Finland
Evaluation of communicative skills
3.6
12.4
55
151
FBE10
NOMESCO Finland
Expansion or reconstruction of pulmonary artery using patch
17.0
12.3
19
11
Z31.5
ICD-10 Finland
Genetic counselling
2.1
12.3
148
725
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.1
12.0
140
680
FBE35
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery with insertion of stent
26.2
11.9
16
6
GE1BE
NOMESCO Finland
Mediastinal ultrasound examinaiton through oesophagus
17.7
11.9
18
10
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
2.8
11.8
75
267
I44.2
ICD-10 Finland
Atrioventricular block, complete
3.9
11.8
47
118
I42.0
ICD-10 Finland
Dilated cardiomyopathy
3.4
11.5
55
161
Q25.48
ICD-10 Finland
Other congenital malformations of the aorta
29.4
11.5
15
5
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
16.1
11.5
18
11
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
18.5
11.4
17
9
Q22.5
ICD-10 Finland
Ebstein anomaly
22.4
11.4
16
7
AA5HE
NOMESCO Finland
Brain ultrasound examination in a child
2.8
11.4
71
249
Q25.21
ICD-10 Finland
Interrupted aortic arch
+∞
11.4
11
*
I97.0
ICD-10 Finland
Postcardiotomy syndrome
10.9
11.3
21
19
H53.0
ICD-10 Finland
Amblyopia ex anopsia
3.5
11.3
52
148
7AX01
NOMESCO Finland
NA
8.4
11.3
24
28
I44.1
ICD-10 Finland
Atrioventricular block, second degree
5.0
11.2
35
69
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
14.7
11.1
18
12
PD5BD
NOMESCO Finland
Extensive CT of aorta
4.2
11.0
41
97
F83
ICD-10 Finland
Mixed specific developmental disorders
2.9
11.0
68
236
R50.9
ICD-10 Finland
Fever, unspecified
1.6
11.0
336
2214
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
6.1
11.0
29
47
PD5CG
NOMESCO Finland
Extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
12.4
11.0
19
15
C01BC04
ATC
flecainide; systemic
3.0
10.9
63
211
FBE32
NOMESCO Finland
Percutaneous transluminal angioplasty of pulmonary artery
10.9
10.9
20
18
K91
ICPC
Cerebrovascular disease
6.0
10.8
29
48
WX002
NOMESCO Finland
Sedation and analgesia
1.6
10.8
318
2072
FJD20
NOMESCO Finland
Bypass of pulmonary valve with ventriculopulmonary prosthesis or homograft
42.4
10.8
13
*
51
HP
Other heart surgery
42.4
10.8
13
*
H52.2
ICD-10 Finland
Astigmatism
2.8
10.7
67
236
R00.2
ICD-10 Finland
Palpitations
2.0
10.7
135
677
FM1BD
NOMESCO Finland
Extensive CT of heart
11.7
10.7
19
16
Q24.3
ICD-10 Finland
Pulmonary infundibular stenosis
27.4
10.6
14
5
FPF20
NOMESCO Finland
Implantation of epicardial pacemaker with atrial and ventricular electrodes
17.4
10.6
16
9
C02KX01
ATC
bosentan; oral
21.0
10.5
15
7
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
58.8
10.5
12
*
R4130
NOMESCO Finland
Speech therapy
2.6
10.4
73
276
FHB96
NOMESCO Finland
Other closure of congenital ventricular septal defect
+∞
10.3
10
*
FM2FN
NOMESCO Finland
Intra cardiac shunt isotope imaging
+∞
10.3
10
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
+∞
10.3
10
*
Q21.8
ICD-10 Finland
Other congenital malformations of cardiac septa
+∞
10.3
10
*
I48.4
ICD-10 Finland
Atypical atrial flutter
13.9
10.3
17
12
Q21.2
ICD-10 Finland
Atrioventricular septal defect
107.7
10.3
11
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
107.7
10.3
11
*
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
4.8
10.2
33
68
TFP35
NOMESCO Finland
Electroanatomical mapping
4.2
10.2
37
86
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
10.1
637
4852
WW502
NOMESCO Finland
Autotransfusion
8.6
10.1
21
24
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
3.3
9.9
49
148
UGC02
NOMESCO Finland
Rigid bronchoscopy
5.1
9.9
30
58
I28.8
ICD-10 Finland
Other specified diseases of pulmonary vessels
39.1
9.8
12
*
PA7BD
NOMESCO Finland
CT angiography of neck and brain
4.3
9.8
35
80
Q23.3
ICD-10 Finland
Congenital mitral insufficiency
14.3
9.8
16
11
FXA20
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and circulatory arrest at concurrent surgical procedure
14.3
9.8
16
11
Z87.6
ICD-10 Finland
Personal history of certain conditions arising in the perinatal period
2.7
9.8
63
228
TFP45
NOMESCO Finland
Ablation treatment of non-typical atrial flutter
25.5
9.7
13
5
Q21.32
ICD-10 Finland
Pulmonary atresia with Fallot ventricular septal defect
19.6
9.7
14
7
74689
ICD-8 Finland
Congenital anomalies of heart, Aliae definitae
53.8
9.5
11
*
Q20.8
ICD-10 Finland
Other congenital malformations of cardiac chambers and connections
53.8
9.5
11
*
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
53.8
9.5
11
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.5
9.5
338
2300
I50.1
ICD-10 Finland
Left ventricular failure
2.7
9.5
61
220
I48.2
ICD-10 Finland
Chronic atrial fibrillation
3.7
9.5
40
107
I49.1
ICD-10 Finland
Atrial premature depolarization
2.8
9.5
60
214
R47.0
ICD-10 Finland
Dysphasia and aphasia
5.7
9.4
26
45
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
5.4
9.4
27
49
K80
ICPC
Cardiac arrhythmia NOS
2.0
9.4
116
575
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.5
9.4
297
1968
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
9.8
9.3
18
18
I51.0
ICD-10 Finland
Cardiac septal defect, acquired
97.9
9.3
10
*
FLE96
NOMESCO Finland
Other repair of outlet obstruction of left ventricle
97.9
9.3
10
*
Q22.41
ICD-10 Finland
Tricuspid atresia
97.9
9.3
10
*
Q21
ICD-10 Finland
Congenital malformations of cardiac septa
+∞
9.3
9
*
7456C
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Endocardial cushion defects[ASD CANALIS ATRIOVENTRICULARIS COMMUNIS]
+∞
9.3
9
*
FDE10
NOMESCO Finland
Ligature of patent ductus arteriosus
29.4
9.3
12
*
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
3.9
9.2
36
90
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.4
9.1
73
299
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
9.1
158
890
M01AE01
ATC
ibuprofen; systemic, rectal
0.8
8.8
1461
15612
ZX199
NOMESCO Finland
Other rote
4.5
8.7
29
63
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
4.2
8.7
31
72
I47.2
ICD-10 Finland
Ventricular tachycardia
3.3
8.6
42
127
74629
ICD-8 Finland
Congenital anomalies of heart, Tetralogy of Fallot
48.9
8.6
10
*
FJD96
NOMESCO Finland
Other operation on right ventricle outlet for congenital or acquired obstruction
48.9
8.6
10
*
AD1
HP
TVP
48.9
8.6
10
*
FJF10
NOMESCO Finland
Replacement of pulmonary valve using biological prosthesis
48.9
8.6
10
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.9
8.6
116
598
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
3.5
8.6
38
107
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.7
8.5
182
1087
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.3
8.5
74
317
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
8.4
232
1485
Q24.0
ICD-10 Finland
Dextrocardia
26.9
8.4
11
*
Q87.06
ICD-10 Finland
Velocardiofacial syndrome
26.9
8.4
11
*
74709
ICD-8 Finland
Other congenital anomalies of circulatory system, Patent ductus arteriosus
26.9
8.4
11
*
Q24.6
ICD-10 Finland
Congenital heart block
19.6
8.4
12
6
FPD00
NOMESCO Finland
Maze procedure for atrial fibrillation
19.6
8.4
12
6
C09AA02
ATC
enalapril; systemic
1.6
8.3
236
1521
Q21.3
ICD-10 Finland
Tetralogy of Fallot
88.1
8.3
9
*
5609
FHL
Other measure in this category
+∞
8.3
8
*
7454E
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[VSD MULTIPLEX]
+∞
8.3
8
*
1EA01
NOMESCO Finland
NA
12.5
8.2
14
11
UDC00
NOMESCO Finland
Ear microscopy
1.8
8.2
147
835
K83
ICPC
Heart valve disease NOS
4.9
8.1
25
50
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
14.2
8.1
13
9
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
2.5
8.0
59
231
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
2.7
8.0
53
197
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
5.9
8.0
21
35
FM1AD
NOMESCO Finland
CT of heart
16.8
8.0
12
7
F82
ICD-10 Finland
Specific developmental disorder of motor function
2.8
7.9
50
178
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
4.2
7.9
28
65
P07.3
ICD-10 Finland
Other preterm infants
2.6
7.9
54
202
C01BD07
ATC
dronedarone; oral
6.7
7.9
19
28
FPW96
NOMESCO Finland
Other operation for arhythmia or disturbance of impulse propagation
8.7
7.9
16
18
H66.9
ICD-10 Finland
Otitis media, unspecified
1.5
7.8
251
1667
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
5.7
7.8
21
36
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
7.1
7.8
18
25
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
4.5
7.8
26
57
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
4.5
7.8
26
57
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.7
7.8
150
873
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.5
7.7
308
2141
I44.0
ICD-10 Finland
Atrioventricular block, first degree
5.3
7.6
22
41
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
4.0
7.6
29
72
73
HP
Initial pacemaker installation
9.2
7.6
15
16
FBJ10
NOMESCO Finland
Anastomosis to pulmonary artery from subclavian artery with interposition graft
14.7
7.6
12
8
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
1.8
7.5
119
649
XG460
NOMESCO Finland
Short time oxymetry
3.8
7.5
30
78
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
3.6
7.5
32
88
TFP44
NOMESCO Finland
Ablation treatment of typical atrial flutter
5.4
7.5
21
38
FHE30
NOMESCO Finland
Repair of tetralogy of Fallot with transannular patch
17.9
7.5
11
6
APX
HP
Other cardiac catheter operation
24.5
7.5
10
*
Q21.31
ICD-10 Finland
Tetralogy of Fallot and double outlet right ventricle
24.5
7.5
10
*
Q90
ICD-10 Finland
Down syndrome
24.5
7.5
10
*
C02KX04
ATC
macitentan; oral
24.5
7.5
10
*
H53.1
ICD-10 Finland
Subjective visual disturbances
1.9
7.4
103
537
3A064
NOMESCO Finland
NA
9.8
7.4
14
14
K89
ICPC
Transient cerebral ischaemia
5.6
7.3
20
35
Q25.70
ICD-10 Finland
Aneurysm, congenital of pulmonary artery
78.3
7.3
8
*
7452A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Tetralogy of Fallot[TETRALOGIA FALLOT]
78.3
7.3
8
*
7451A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[TRANSPOSITIO CORDIS COMPLETA]
78.3
7.3
8
*
FPK00
NOMESCO Finland
Implantation of electrocardiograph with loop recorder
6.9
7.3
17
24
R07.2
ICD-10 Finland
Precordial pain
3.2
7.3
36
111
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
7.3
437
3276
PD5DG
NOMESCO Finland
Very extensive MRI examination of thoracal and abdominal aortta with high intensity magnet
13.1
7.3
12
9
Q25.3
ICD-10 Finland
Stenosis of aorta
13.1
7.3
12
9
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
7.2
294
2055
Q22.2
ICD-10 Finland
Congenital pulmonary valve insufficiency
+∞
7.2
7
*
7459X
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Unspecified defect of septal closure
+∞
7.2
7
*
5501
FHL
Pulmonary artery stenosis
+∞
7.2
7
*
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.0
7.2
93
472
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.8
7.2
109
588
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
10.6
7.2
13
12
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.8
7.2
116
639
71
HP
Electrophysiological Special Examination
6.7
7.1
17
25
KFH00
NOMESCO Finland
Operation for undescended or ectopic testis
4.2
7.1
25
58
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
6.1
7.1
18
29
Q20.00
ICD-10 Finland
Common arterial trunk
29.3
7.1
9
*
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
3.4
7.1
32
93
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
7.0
362
2643
4302
FHL
Tooth patching under general anesthesia
19.6
7.0
10
5
B01AF01
ATC
rivaroxaban; oral
1.7
7.0
143
846
RS221
NOMESCO Finland
NA
2.5
7.0
50
195
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
1.7
6.9
125
715
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
5.5
6.9
19
34
TKC20
NOMESCO Finland
Catheterisation of bladder
1.9
6.9
95
496
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
6.8
6.9
16
23
C08DA01
ATC
verapamil; systemic
2.3
6.8
58
248
XF405
NOMESCO Finland
Symptom ECG
4.0
6.8
25
61
5210A
ICD-9 Finland
Diseases of hard tissues of teeth, Dental caries
13.5
6.8
11
8
D68.8
ICD-10 Finland
Other specified coagulation defects
3.9
6.8
26
66
G45
ICD-10 Finland
Transient cerebral ischaemic attacks and related syndromes
7.4
6.8
15
20
RK260
NOMESCO Finland
NA
7.4
6.8
15
20
342
Kela drug reimbursment
Dronedarone
5.3
6.8
19
35
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
3.2
6.7
33
102
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
10.7
6.7
12
11
FM1CE
NOMESCO Finland
Ultrasound examination of heart through catheter
39.1
6.7
8
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.8
6.7
101
546
FAE00
NOMESCO Finland
Anastomosis to pulmonary artery from superior vena cava
16.3
6.6
10
6
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
2.9
6.6
38
128
XX3DW
NOMESCO Finland
Time consuming IT work
1.7
6.6
144
867
WX870
NOMESCO Finland
Other postsurgical intensive care
5.5
6.6
18
32
SPAT1097
SPAT
Recording of ECG
1.5
6.6
199
1302
FB1BC
NOMESCO Finland
Extensive angiography of arteria pulmonalis
22.0
6.6
9
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
6.6
137
818
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
6.6
206
1363
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
2.7
6.5
42
153
T14.5
ICD-10 Finland
Injury of blood vessel(s) of unspecified body region
7.6
6.5
14
18
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
6.5
332
2421
3A019
NOMESCO Finland
NA
5.7
6.5
17
29
WZC30
NOMESCO Finland
Teaching
1.5
6.4
213
1429
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
6.4
238
1636
SPAT1263
SPAT
Sampling
1.3
6.4
797
6617
N18
ICPC
Paralysis/weakness
3.7
6.4
26
70
4168X
ICD-9 Finland
Chronic pulmonary heart disease, Other chronic pulmonary heart diseases
68.3
6.4
7
*
AH2
HP
Treatment of atrial fibrillation by maze surgery or its modification as the only procedure
68.3
6.4
7
*
TFW99
NOMESCO Finland
Other minor procedure in cardiac surgery
68.3
6.4
7
*
Q90.1
ICD-10 Finland
Trisomy 21, mosaicism (mitotic nondisjunction)
68.3
6.4
7
*
FFF20
NOMESCO Finland
Anastomosis to left atrium from partially anomalous pulmonary veins
68.3
6.4
7
*
B01AE07
ATC
dabigatran etexilate; oral
2.3
6.3
55
239
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
5.2
6.3
18
34
4304
FHL
Tooth or tooth extraction under general anesthesia
14.0
6.3
10
7
FXA13
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia and exclusive cerebral perfusion
14.0
6.3
10
7
B01AC07
ATC
dipyridamole; systemic
2.5
6.3
45
176
ZX108
NOMESCO Finland
Inhalation
3.4
6.3
28
81
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
2.3
6.2
56
245
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
10.8
6.2
11
10
FFE10
NOMESCO Finland
Creation or expansion of ASD in open heart surgery
+∞
6.2
6
*
5512
FHL
Cleavage or ligation of the ductus arteriosus
+∞
6.2
6
*
75988
ICD-8 Finland
Congenital syndromes affecting multiple systems, Aliae definitae
+∞
6.2
6
*
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
6.2
6
*
FFF96
NOMESCO Finland
Other operation for partially anomalous pulmonary veins
+∞
6.2
6
*
5513
FHL
Coarctation resection, plastic or bypass
+∞
6.2
6
*
FFD20
NOMESCO Finland
Closure of atrio-ventricular septal defect using patch
+∞
6.2
6
*
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
17.6
6.2
9
5
I63.8
ICD-10 Finland
Other cerebral infarction
5.0
6.2
18
35
A03FA02
ATC
cisapride; oral, rectal
1.8
6.2
106
599
I37.2
ICD-10 Finland
Pulmonary valve stenosis with insufficiency
26.1
6.1
8
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.2
6.1
58
259
SPAT1266
SPAT
Separate instruction to prepare for procedure
2.5
6.1
44
173
ZX120
NOMESCO Finland
Intravenous
1.6
6.1
167
1073
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
2.1
6.1
65
307
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
3.0
6.0
31
100
J45.1
ICD-10 Finland
Nonallergic asthma
1.6
6.0
151
949
Y0399
ICD-8 Finland
Investigation of circulatory system
5.2
6.0
17
32
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
461
910
5.84
221.89
3.9
6.7
94.4
92.4
%
0.97
437
879
1041
3889
3.76
219.14
4.9
3.4
1120.6
1214.5
ng/l
0.32
929
3253
1382
6284
3.55
212.39
15.0
7.6
1.5
1.2
inr
15.80
374
1866
843
2872
3.81
201.10
3.4
3.7
31.2
30.1
s
4.04
829
2806
246
305
8.64
182.23
1.1
1.2
116.6
111.9
%
1.06
239
283
229
340
7.15
144.57
1.1
1.1
—
—
—
0
0
422
1147
4.12
134.45
4.0
3.7
188.7
183.3
ng/l
0.09
377
1031
215
342
6.63
126.92
1.3
1.3
3.9
5.0
u/ml
0.46
91
162
1000
4911
2.64
115.08
5.3
5.4
81.0
90.9
%
26.01
984
4802
199
342
6.09
108.53
1.3
1.3
3.2
3.7
u/ml
0.14
70
125
319
843
4.09
104.47
3.0
5.0
157.3
169.6
%
1.98
314
819
908
4552
2.49
96.58
2.4
2.6
—
—
—
0
0
895
4872
2.24
74.83
2.7
2.2
232.6
239.8
u/l
0.08
858
4624
1355
8693
2.13
74.13
4.0
4.1
—
—
—
0
0
635
3036
2.40
71.63
4.2
3.5
1192.9
542.2
ng/l
2.10
498
2100
603
2934
2.33
64.52
5.9
6.5
0.8
0.8
mmol/l
2.10
578
2774
78
83
9.45
64.46
1.0
1.1
99.1
91.7
%
0.97
73
68
84
100
8.47
63.66
1.2
1.2
21.6
10.8
u/ml
—
5
13
1581
11125
2.05
62.98
7.1
5.7
6.2
6.5
mmol/l
8.60
1506
10352
401
1662
2.62
60.55
44.3
20.8
1.9
1.2
inr
5.92
35
235
86
114
7.61
59.58
1.1
1.1
1.1
1.1
ratio
0.81
22
47
958
5754
2.01
58.61
4.3
3.2
45.2
47.5
ng/l
0.08
655
3491
249
850
3.07
53.87
4.3
5.8
3.0
3.2
g/l
1.77
241
820
58
55
10.54
51.99
4.7
8.5
—
—
—
0
0
418
1916
2.36
50.16
8.0
11.4
7.0
7.5
mmol/l
0.92
411
1857
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
175
517
3.48
47.84
9.8
8.1
0.4
0.3
u/ml
1.00
128
291
1221
8630
1.74
39.92
10.6
8.6
1.2
1.2
mmol/l
4.94
1146
7960
537
2982
1.97
38.42
7.4
8.8
1.2
1.2
mmol/l
0.70
517
2806
2287
19780
2.41
36.93
20.1
14.2
139.5
139.6
mmol/l
1.69
2261
19244
2288
19828
2.39
36.14
20.1
14.3
4.0
4.0
mmol/l
1.72
2259
19243
270
1201
2.34
34.04
2.2
2.3
14.6
7.1
ug/l
4.28
238
1059
1271
9355
1.66
33.58
9.7
8.7
1.2
1.2
mmol/l
3.49
1063
8144
337
1733
2.04
29.35
12.6
9.4
5.3
5.1
kpa
1.97
328
1664
337
1733
2.04
29.35
12.6
9.4
13.4
12.9
kpa
0.81
328
1667
335
1732
2.03
28.71
12.7
9.4
1.0
0.9
mmol/l
0.08
281
1364
200
853
2.41
27.59
17.5
13.1
—
—
—
0
0
392
2168
1.91
27.57
9.6
8.2
1.8
1.0
mmol/l
6.66
321
1578
303
1548
2.04
26.75
13.5
10.0
96.0
95.4
%
0.75
295
1496
395
2214
1.88
26.60
9.6
8.2
5.2
5.1
kpa
2.77
387
2114
220
999
2.26
26.25
15.0
11.6
94.6
94.1
%
0.44
220
994
2286
20292
2.09
25.85
16.5
12.5
22.9
22.4
mg/l
0.26
1851
15350
2320
20781
2.15
24.39
17.8
13.5
70.7
70.8
umol/l
0.03
2320
20773
423
2500
1.79
23.79
2.9
2.9
21.5
22.9
%
1.41
381
2211
1188
9083
1.53
23.40
7.2
6.6
16.5
13.9
umol/l
2.63
1103
8564
627
4161
1.63
22.88
2.8
2.5
1.2
1.2
mg/l
0.04
467
3105
439
2692
1.72
21.53
2.8
2.7
2.5
2.4
g/l
0.88
409
2514
296
1619
1.89
21.24
3.2
3.0
—
—
—
0
0
1253
9818
1.49
21.13
10.1
10.0
0.0
0.0
e9/l
0.37
1005
7871
268
1425
1.94
20.93
12.1
9.9
122.2
122.6
g/l
0.11
257
1378
469
2954
1.68
20.76
2.9
2.7
12.7
13.7
umol/l
2.03
438
2768
1292
10213
1.49
20.68
6.7
7.4
2.9
3.0
%
0.75
1237
9636
994
7502
1.49
19.74
5.7
5.8
36.2
36.4
g/l
0.38
929
7024
1327
10645
1.46
19.06
6.7
7.4
29.3
31.2
%
7.56
1269
10067
52
129
4.01
18.35
1.2
1.2
—
—
—
0
0
433
2769
1.64
17.83
1.9
1.9
—
—
—
0
0
297
1714
1.79
17.82
13.8
10.0
1.4
1.4
mmol/l
0.12
285
1613
236
1283
1.88
17.15
3.7
4.1
1.2
1.2
mmol/l
0.85
221
1116
1298
10492
1.43
17.13
6.5
7.2
55.6
54.0
%
4.80
1247
9952
686
4955
1.49
16.24
2.7
2.5
3.2
2.8
mg/l
2.37
606
4290
401
2572
1.62
16.20
6.2
8.0
5.9
5.8
kpa
1.42
393
2510
1459
12112
1.42
16.20
8.6
9.9
3.9
3.9
e9/l
0.52
1267
10447
399
2561
1.62
16.06
6.3
8.0
1.5
1.4
mmol/l
0.04
330
2029
316
1935
1.68
15.25
5.9
8.6
24.0
23.7
mmol/l
0.98
306
1838
1623
13863
1.41
14.44
7.7
7.0
89.2
88.0
u/l
0.29
1534
13049
1655
14187
1.41
14.40
4.4
4.1
9.4
10.2
mm/h
1.80
1559
13221
361
2320
1.61
14.36
6.2
7.9
5.3
4.9
kpa
1.57
355
2262
62
211
2.92
13.49
2.7
3.1
0.8
0.8
nmol/l
0.07
48
165
305
1940
1.61
12.59
3.5
4.9
272.8
258.0
u/l
0.47
291
1849
157
832
1.90
12.33
4.9
7.2
1.3
1.2
%
0.10
157
826
111
529
2.10
11.76
1.9
1.6
—
—
—
0
0
85
370
2.29
11.27
2.8
2.8
17.1
16.9
%
0.22
47
212
2002
18049
1.41
10.81
20.2
15.7
13.6
13.4
%
2.08
1979
17677
303
1994
1.55
10.76
1.9
1.9
—
—
—
0
0
1144
9497
1.33
10.71
3.5
3.0
95.5
96.2
ug/l
0.04
1066
8898
301
1981
1.55
10.68
1.9
1.8
—
—
—
0
0
132
695
1.91
10.60
1.8
2.1
1.3
1.4
g/l
1.23
109
611
295
1942
1.55
10.45
3.0
3.2
0.2
0.2
g/l
1.35
288
1843
69
289
2.37
10.02
2.4
2.2
1.8
1.7
mmol/l
0.40
69
283
707
5511
1.35
9.99
3.5
3.5
0.5
0.4
e6/l
0.35
557
4116
543
4057
1.39
9.99
3.2
2.9
5.4
6.4
e6/l
1.12
480
3569
328
2243
1.49
9.71
3.6
4.4
1.8
1.6
%
1.57
299
2059
40
130
3.04
9.51
2.0
1.4
1673.1
2140.5
e6/l
0.30
32
91
1454
12608
1.30
9.38
4.7
4.2
425.7
1931.5
e6/l
1.46
24
155
37
119
3.07
8.97
1.9
1.4
70402.3
29081.8
e6/l
0.61
26
70
793
6380
1.31
8.81
4.0
3.7
33.0
32.0
u/l
0.15
753
6083
1854
16687
1.33
8.74
14.5
10.7
88.3
88.7
ml/min/173m2
0.23
1568
13240
197
1234
1.61
8.63
3.8
3.4
4.8
4.7
pmol/l
0.12
178
1109
104
544
1.91
8.57
5.2
6.4
23.4
24.2
mmol/l
1.45
97
496
108
573
1.88
8.53
1.8
1.9
—
—
—
0
0
275
1864
1.50
8.47
7.0
6.0
—
—
—
0
0
107
571
1.87
8.31
1.8
2.0
—
—
—
0
0
86
426
2.01
8.30
1.9
2.0
—
—
—
0
0
79
385
2.04
7.99
1.5
1.9
—
—
—
0
0
2427
23018
1.84
7.88
24.9
18.2
4.5
4.6
e12/l
3.74
2373
22237
194
1241
1.57
7.79
2.2
2.9
65.5
66.5
g/l
0.86
178
1150
1988
18168
1.33
7.78
5.1
4.4
2.0
2.0
mu/l
0.34
1852
16928
2425
23002
1.82
7.74
24.9
18.3
248.3
259.5
e9/l
13.87
2377
22280
2427
23027
1.83
7.74
25.5
18.4
133.8
135.3
g/l
5.19
2411
22723
2427
23029
1.82
7.70
24.9
18.3
6.8
6.8
e9/l
0.50
2375
22256
680
5438
1.31
7.70
2.7
2.7
60.2
56.6
u/l
1.07
616
5048
150
906
1.66
7.62
9.8
7.9
24.7
24.5
mmol/l
0.43
139
849
61
275
2.20
7.55
7.8
8.0
12.1
10.8
mg/l
0.81
52
257
106
583
1.81
7.51
3.5
2.5
691.0
403.9
ug/l
0.55
100
539
20
48
4.10
7.48
1.4
1.5
—
—
—
0
0
721
5837
1.29
7.39
2.9
3.2
2.4
2.4
mmol/l
0.27
632
5187
319
2302
1.41
7.04
4.7
4.4
8.4
7.0
umol/l
0.67
280
1954
89
474
1.87
7.00
2.2
2.6
—
—
—
0
0
82
432
1.89
6.69
2.5
2.5
134.7
131.8
g/l
0.50
63
338
351
2612
1.37
6.42
1.8
1.7
1227.7
1180.4
nmol/l
0.40
259
1999
2124
19784
1.32
5.90
19.0
14.1
39.5
39.9
%
1.21
1660
15877
1714
15566
1.24
5.84
4.4
3.8
14.7
14.6
pmol/l
1.96
1577
14293
58
285
2.01
5.83
1.1
1.2
—
36.0
—
0
5
183
1235
1.48
5.79
3.1
2.6
67.5
71.6
ml/min/173m2
0.55
66
451
50
234
2.11
5.72
3.1
5.0
5.9
6.6
mmol/l
1.52
43
200
65
336
1.92
5.66
1.7
2.0
—
—
—
0
0
73
401
1.80
5.29
3.9
4.1
55.7
55.2
%
0.10
73
401
49
236
2.05
5.23
1.9
1.7
—
—
—
0
0
101
613
1.64
5.13
1.4
1.8
—
—
—
0
0
67
364
1.82
5.05
1.5
1.6
—
—
—
0
0
56
287
1.93
5.04
1.9
1.6
—
—
—
0
0
600
4950
1.24
4.96
4.1
3.7
0.0
0.0
estimate
0.22
232
1723
49
241
2.01
4.96
1.3
1.6
—
—
—
0
0
26
97
2.64
4.95
1.2
1.1
80.2
89.7
%
0.70
16
44
52
262
1.96
4.92
1.5
1.5
—
—
—
0
0
105
652
1.60
4.88
2.0
1.9
—
—
—
0
0
59
312
1.87
4.85
1.8
1.5
—
—
—
0
0
1743
15983
1.22
4.82
5.0
4.9
38.0
38.7
mmol/mol
3.41
1634
14989
42
198
2.09
4.77
2.5
2.2
31.9
32.6
pg
0.36
42
198
31
129
2.37
4.73
4.6
6.3
129.3
72.1
mg/l
1.33
23
116
211
1520
1.39
4.73
5.5
5.8
73.6
72.5
ng/l
0.09
184
1404
21
72
2.87
4.67
1.5
1.4
13.3
13.6
u/l
0.04
21
67
25
95
2.59
4.61
1.3
1.3
71.1
82.4
%
0.64
15
43
48
242
1.96
4.56
1.1
1.1
—
—
—
0
0
7
5
13.73
4.52
1.1
1.0
—
—
—
0
0
69
392
1.74
4.52
3.6
3.7
4.1
4.0
e9/l
0.15
69
392
85
515
1.64
4.40
2.4
1.9
3.4
4.8
iu/l
1.25
28
187
454
3676
1.25
4.39
1.5
1.5
19.8
20.5
nmol/l
0.52
386
3167
110
710
1.54
4.36
1.2
1.2
3.5
1.0
u/ml
—
5
57
61
338
1.78
4.36
1.6
1.6
—
—
—
0
0
2208
20843
1.29
4.30
11.4
9.6
26.0
26.5
u/l
0.52
2152
20172
59
325
1.79
4.30
10.7
10.1
106.3
105.5
mmol/l
0.89
52
295
21
76
2.72
4.26
1.2
1.1
84.4
80.0
%
—
5
17
53
284
1.84
4.23
1.3
1.6
—
—
—
0
0
49
256
1.89
4.22
1.1
1.1
—
—
—
0
0
1421
12876
1.18
4.12
3.7
3.4
45.0
42.2
u/l
0.72
1353
12190
74
441
1.66
4.10
1.7
2.6
0.4
0.9
g/l
1.54
61
401
35
164
2.10
4.08
1.7
2.3
—
—
—
0
0
46
240
1.89
4.00
1.0
1.0
—
—
—
0
0
108
711
1.51
3.94
1.3
1.6
1.1
1.2
g/l
0.57
102
677
89
562
1.57
3.92
2.6
3.4
31.6
34.4
umol/l
0.73
83
491
78
480
1.61
3.83
1.7
2.4
10.5
10.4
g/l
0.04
62
418
92
589
1.55
3.83
1.9
1.8
—
—
—
0
0
68
409
1.64
3.67
1.4
2.3
38.2
38.4
g/l
0.05
57
362
755
6536
1.19
3.66
2.0
1.9
96.7
96.4
pmol/l
0.07
429
3475
78
486
1.59
3.66
1.7
2.4
3.0
3.1
g/l
0.45
61
390
79
495
1.58
3.62
1.5
1.4
—
—
—
0
0
79
495
1.58
3.62
1.5
1.4
—
—
—
0
0
91
592
1.52
3.54
8.5
7.0
1.8
1.6
%
1.73
84
556
86
557
1.53
3.43
1.3
2.7
3.6
3.5
mmol/l
0.29
78
529
231
1775
1.30
3.42
1.2
1.4
189.1
277.2
u/ml
1.24
217
1659
1066
9530
1.16
3.41
3.8
3.4
0.0
0.0
estimate
0.50
227
1729
553
4683
1.20
3.41
1.6
1.7
1.3
1.4
mmol/l
0.87
458
4056
62
372
1.65
3.41
1.4
2.5
0.0
0.0
g/l
0.00
54
349
31
150
2.03
3.37
1.5
1.6
—
—
—
0
0
31
150
2.03
3.37
1.5
1.6
—
—
—
0
0
31
150
2.03
3.37
1.5
1.6
—
—
—
0
0
186
1391
1.33
3.35
2.2
2.3
21.5
19.0
au/ml
—
9
85
17
63
2.65
3.34
2.0
1.7
—
—
—
0
0
65
398
1.61
3.31
1.4
2.4
0.0
0.0
g/l
0.50
57
374
29
139
2.05
3.25
1.5
1.8
—
—
—
0
0
88
582
1.50
3.20
2.4
2.1
2.8
1.7
ug/l
0.37
77
516
80
520
1.52
3.16
1.4
1.5
—
—
—
0
0
344
2800
1.23
3.16
2.4
2.7
2.4
2.4
mmol/l
0.99
294
2439
411
3411
1.21
3.13
2.8
3.0
1.0
1.0
e6/l
0.02
238
1922
140
1016
1.37
3.09
1.7
1.7
—
—
—
0
0
76
492
1.53
3.07
1.3
2.2
—
—
—
0
0
79
516
1.51
3.06
1.7
2.3
3.6
3.8
g/l
0.87
59
382
1062
9547
1.15
3.06
5.1
4.8
0.0
0.0
estimate
0.50
242
1784
79
517
1.51
3.04
1.7
2.3
—
—
—
0
0
79
517
1.51
3.04
1.7
2.3
6.8
7.3
g/l
1.70
62
402
16
61
2.58
3.00
2.0
1.7
—
—
—
0
0
16
61
2.58
3.00
2.0
1.7
—
—
—
0
0
60
370
1.60
3.00
1.5
2.5
0.0
0.0
g/l
0.00
54
348
1069
9624
1.15
3.00
3.8
3.5
0.0
0.0
estimate
0.80
234
1732
100
690
1.44
2.96
1.3
1.6
0.2
0.2
g/l
0.15
95
658
83
554
1.48
2.92
1.4
2.9
5.9
25.2
e6/l
0.98
66
419
22
99
2.18
2.90
1.1
1.1
1223.8
1653.8
miu/ml
1.45
22
99
83
555
1.48
2.90
1.4
2.9
216.7
852.2
e6/l
1.25
68
435
240
1897
1.26
2.88
4.5
4.0
34.4
32.1
%
2.68
183
1343
173
1311
1.31
2.88
2.0
2.4
8802.7
6626.2
u/l
0.32
56
483
9
22
4.01
2.82
2.4
2.0
—
—
—
0
0
7
13
5.28
2.82
1.1
1.1
—
—
—
0
0
10
30
3.27
2.80
1.1
1.1
—
—
—
0
0
19
82
2.28
2.77
1.8
1.7
—
—
—
0
0
19
82
2.28
2.77
1.9
1.7
—
—
—
0
0
19
82
2.28
2.77
1.9
1.7
—
—
—
0
0
19
82
2.28
2.77
1.9
1.7
—
—
—
0
0
63
402
1.55
2.75
1.8
1.4
—
—
—
0
0
15
58
2.54
2.75
1.7
1.4
—
—
—
0
0
167
1269
1.31
2.74
1.3
1.3
15.9
48.6
au/ml
—
7
48
22
102
2.12
2.72
1.4
1.2
—
—
—
0
0
5
6
8.17
2.71
1.0
1.0
—
—
—
0
0
161
1222
1.31
2.67
1.7
1.7
—
—
—
0
0
62
401
1.53
2.57
1.1
1.3
5.2
4.7
u/ml
—
6
29
133
1693
0.76
2.56
1.1
1.1
—
—
—
0
0
803
7151
1.14
2.54
3.9
3.5
—
—
—
0
0
9
25
3.53
2.51
1.2
1.2
—
—
—
0
0
8
20
3.92
2.51
1.1
1.7
57.0
102.3
ng/l
—
8
20
26
134
1.91
2.45
1.8
1.5
25.1
35.7
%
0.77
17
94
46
281
1.61
2.44
2.8
3.8
1.0
1.4
%
0.50
39
229
226
1814
1.24
2.40
2.9
3.3
10.0
9.9
g/l
0.08
217
1699
493
4259
1.16
2.36
3.5
3.0
3930.2
5202.3
umol/l
0.25
433
3785
1876
17689
1.15
2.35
4.5
3.9
4.4
4.7
mmol/l
32.00
1776
16648
33
188
1.73
2.29
1.1
1.1
—
—
—
0
0
1795
16888
1.14
2.27
4.2
3.6
1.2
1.3
mmol/l
6.63
1680
15771
28
152
1.81
2.27
1.2
1.2
—
—
—
0
0
100
730
1.35
2.21
7.9
4.9
55.1
51.5
%
0.75
100
714
73
507
1.42
2.17
1.2
1.3
6.1
12.1
u/ml
0.68
16
78
385
3284
1.17
2.17
3.2
3.2
2.9
2.7
e6/l
0.20
210
1804
15
66
2.23
2.13
1.6
1.4
3.3
4.2
%
—
6
15
8
24
3.27
2.13
1.3
1.3
—
—
—
0
0
1859
17563
1.13
2.10
4.5
3.9
1.4
1.5
mmol/l
3.84
1750
16434
11
42
2.57
2.09
1.6
1.7
—
—
—
0
0
31
179
1.70
2.07
1.8
2.2
35.3
27.7
mg/l
—
7
51
32
507
0.61
2.06
1.0
1.1
2.0
0.3
u/ml
0.38
13
197
19
94
1.98
2.04
1.3
1.2
—
—
—
0
0
169
1342
1.25
2.02
3.0
4.2
4.9
23.5
ug/l
1.99
133
1063
33
196
1.66
2.00
1.1
1.2
24.9
35.1
mg/l
2.09
28
156
22
116
1.86
1.98
1.2
1.1
—
38.4
—
0
7
71
501
1.40
1.96
1.2
1.2
2.1
4.5
u/ml
—
9
48
1887
17872
1.13
1.95
4.9
4.3
2.6
2.8
mmol/l
20.34
1773
16699
26
147
1.74
1.89
1.5
1.3
62764.8
132490.5
e6/l
0.40
21
107
73
523
1.38
1.86
9.5
8.5
1226.7
339.6
iu/ml
0.66
12
79
198
1616
1.22
1.85
1.3
1.2
148.9
150.5
iu/ml
0.02
76
565
17
84
1.99
1.85
1.1
1.1
—
—
—
0
0
20
105
1.87
1.84
1.3
1.7
—
—
—
0
0
1820
17223
1.12
1.83
4.3
3.9
5.7
5.8
mmol/l
1.29
1666
15884
30
181
1.63
1.75
1.7
1.6
61.6
56.3
%
0.39
23
124
122
952
1.27
1.73
1.6
1.9
—
—
—
0
0
62
439
1.39
1.71
1.2
1.1
—
—
—
0
0
97
736
1.30
1.71
1.5
2.0
37.9
39.8
u/l
0.53
83
669
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
27
160
1.66
1.69
1.1
1.2
—
—
—
0
0
131
1037
1.25
1.65
1.5
1.5
—
—
—
0
0
19
102
1.83
1.65
1.7
5.1
207.2
173.3
umol/l
—
6
60
17
88
1.90
1.65
1.5
1.3
—
—
—
0
0
43
287
1.47
1.64
2.6
3.4
—
—
—
0
0
11
48
2.25
1.62
1.9
2.6
—
—
—
0
0
17
89
1.87
1.60
1.5
1.3
—
—
—
0
0
22
352
0.61
1.54
1.2
1.4
5.5
13.3
u/ml
0.62
12
206
29
435
0.65
1.54
1.1
1.2
53.0
1172.3
iu/ml
—
9
125
66
483
1.35
1.52
4.5
3.7
13.4
8.9
umol/l
0.56
52
388
76
963
0.76
1.52
1.5
1.9
—
—
—
0
0
9
36
2.45
1.48
1.1
1.1
—
—
—
0
0
36
238
1.49
1.46
1.4
1.7
—
—
—
0
0
879
8088
1.10
1.43
3.0
2.6
75.3
74.0
nmol/l
0.73
793
7459
38
531
0.70
1.43
1.3
1.8
—
—
—
0
0
22
130
1.66
1.42
1.5
1.2
—
—
—
0
0
43
298
1.42
1.39
2.6
3.3
16.6
9.9
%
2.48
29
237
27
170
1.56
1.37
1.5
1.2
271.6
113.8
u/l
0.37
17
121
16
87
1.80
1.37
1.1
1.1
—
—
—
0
0
34
226
1.48
1.36
1.4
1.5
299.1
383.5
pmol/l
0.58
27
173
23
140
1.61
1.34
2.0
1.7
—
—
—
0
0
5
17
2.88
1.32
1.2
1.2
—
—
—
0
0
36
244
1.45
1.32
4.7
3.5
1.6
1.7
umol/l
0.43
36
239
12
60
1.96
1.30
1.6
3.2
—
—
—
0
0
25
157
1.56
1.30
1.1
1.1
—
—
—
0
0
209
1778
1.16
1.29
2.4
2.4
43.1
65.0
u/l
0.35
185
1494
67
841
0.77
1.29
1.1
1.2
4.3
3.7
u/ml
0.11
20
262
6
24
2.45
1.27
1.3
1.4
—
—
—
0
0
9
43
2.05
1.26
2.6
1.9
—
—
—
0
0
41
549
0.73
1.24
1.0
1.1
8.8
8.6
u/ml
0.01
25
284
20
121
1.62
1.21
1.0
1.1
1.0
1.0
u/l
—
6
59
358
3174
1.12
1.20
1.3
1.3
16.5
28.0
iu/ml
4.50
96
923
66
504
1.29
1.19
4.9
3.8
25.4
22.3
nmol/l
0.81
66
489
52
384
1.33
1.18
2.2
1.7
11014.8
13388.8
e6/l
0.28
40
287
45
588
0.74
1.17
1.1
1.1
7.2
6.3
u/ml
0.13
25
295
368
3274
1.12
1.17
1.6
1.6
460.9
32337486.7
pmol/l
3.07
288
2777
79
620
1.25
1.15
2.0
2.0
113.8
101.3
u/ml
0.62
20
77
15
86
1.71
1.11
1.1
1.1
—
—
—
0
0
246
2148
1.13
1.08
2.7
2.4
353.6
354.0
nmol/l
0.01
230
2008
36
256
1.38
1.06
1.5
1.2
—
—
—
0
0
73
576
1.25
1.04
1.5
1.4
291.8
318.7
ug/g
0.52
39
319
15
88
1.67
1.04
4.4
3.3
67.2
117.1
ug/l
1.22
15
88
28
191
1.44
1.03
1.4
1.5
—
—
—
0
0
57
438
1.28
1.01
1.1
1.2
30.7
45.5
u/ml
—
6
34
451
4090
1.10
1.00
4.5
4.4
1.7
2.4
ug/l
2.07
382
3701
70
842
0.81
0.99
1.4
1.5
—
—
—
0
0
15
231
0.63
0.97
1.2
2.1
—
—
—
0
0
32
425
0.73
0.97
1.1
1.1
1.3
4.3
u/ml
2.18
17
168
15
90
1.63
0.96
1.3
1.8
—
—
—
0
0
41
523
0.76
0.95
3.4
2.2
0.9
0.7
nmol/l
0.61
35
445
15
91
1.62
0.93
1.3
1.8
—
—
—
0
0
25
341
0.71
0.90
1.4
1.2
—
—
—
0
0
6
28
2.10
0.90
1.3
1.0
—
—
—
0
0
6
29
2.03
0.87
1.0
1.1
—
—
—
0
0
8
42
1.87
0.87
1.6
1.5
—
—
—
0
0
56
676
0.81
0.85
1.8
1.6
2.2
0.1
iu/ml
—
9
136
16
102
1.54
0.83
4.5
5.2
—
—
—
0
0
42
321
1.28
0.81
1.1
1.1
—
—
—
0
0
15
95
1.55
0.80
2.8
3.2
8.8
10.6
mg/l
—
10
79
26
185
1.38
0.80
1.2
1.1
—
—
—
0
0
103
868
1.17
0.79
1.4
1.3
—
—
—
0
0
12
72
1.63
0.79
1.8
1.3
—
—
—
0
0
12
72
1.63
0.79
1.8
1.3
—
—
—
0
0
78
642
1.19
0.79
1.1
1.2
—
—
—
0
0
77
634
1.19
0.78
1.1
1.2
—
—
—
0
0
34
255
1.31
0.76
1.2
1.2
—
—
—
0
0
5
23
2.13
0.75
2.4
10.1
—
—
—
0
0
17
113
1.47
0.75
1.1
1.2
316.7
205.8
iu/ml
0.66
17
113
20
138
1.42
0.74
2.7
4.1
—
—
—
0
0
17
237
0.70
0.73
2.6
1.8
—
—
—
0
0
16
106
1.48
0.72
8.1
8.8
—
—
—
0
0
23
304
0.74
0.72
1.0
1.1
—
—
—
0
0
49
390
1.23
0.71
1.2
1.3
—
—
—
0
0
9
56
1.57
0.70
1.0
1.1
62.0
47.7
u/ml
—
9
56
17
235
0.71
0.70
1.4
1.6
7.9
7.5
mmol/l
0.23
11
144
38
294
1.27
0.70
3.6
3.3
0.3
0.2
e9/l
1.68
29
232
27
199
1.33
0.69
2.1
2.1
16.0
19.6
umol/l
0.57
22
191
5
26
1.88
0.69
1.6
1.0
—
—
—
0
0
12
75
1.57
0.69
1.7
2.5
13.7
18.3
umol/l
1.43
12
75
13
83
1.53
0.69
1.2
1.1
—
—
—
0
0
372
3877
0.93
0.67
2.1
2.3
—
—
—
0
0
38
296
1.26
0.67
3.5
3.3
464.9
573.7
e6/l
1.00
29
231
32
398
0.78
0.67
1.4
1.6
—
—
—
0
0
13
84
1.52
0.66
1.2
1.1
—
—
—
0
0
30
375
0.78
0.65
1.1
1.2
—
—
—
0
0
7
43
1.59
0.65
1.1
1.1
—
—
—
0
0
83
936
0.86
0.65
1.1
1.2
5.6
2.6
u/ml
0.59
47
551
339
3539
0.93
0.64
2.0
2.2
—
—
—
0
0
8
125
0.62
0.64
1.3
1.5
—
—
—
0
0
11
162
0.66
0.63
1.1
3.3
—
—
—
0
0
11
162
0.66
0.63
1.1
3.3
—
—
—
0
0
32
246
1.28
0.63
2.2
1.3
0.6
0.6
nmol/l
0.09
32
234
22
160
1.35
0.63
2.3
3.3
59.3
54.0
%
0.54
16
108
67
764
0.85
0.61
1.4
1.4
—
—
—
0
0
88
752
1.15
0.61
1.6
1.7
276.3
213.3
u/ml
1.15
51
397
17
119
1.40
0.60
1.0
1.1
—
—
—
0
0
67
763
0.86
0.60
1.4
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
2.4
—
—
—
0
0
87
970
0.87
0.59
1.5
1.4
—
—
—
0
0
67
760
0.86
0.58
1.4
1.4
—
—
—
0
0
21
154
1.34
0.58
2.1
2.5
—
—
—
0
0
33
259
1.25
0.57
1.8
1.4
—
—
—
0
0
485
4522
1.06
0.56
4.3
4.1
48.1
9.6
mg/mmol
0.55
312
2963
8
54
1.45
0.56
3.5
6.4
—
—
—
0
0
9
59
1.49
0.54
2.0
1.4
11.5
9.1
ug/l
—
9
59
68
764
0.87
0.53
1.4
1.4
—
—
—
0
0
9
60
1.47
0.53
1.1
1.1
—
—
—
0
0
89
771
1.13
0.53
1.6
1.7
—
—
—
0
0
99
866
1.12
0.51
4.6
3.1
0.1
0.2
e6/l
1.83
99
838
16
115
1.36
0.51
2.6
3.1
860.7
1266.3
u/ml
0.60
16
115
171
1542
1.09
0.50
2.4
2.2
11.5
12.0
nmol/l
0.25
147
1325
17
124
1.34
0.50
2.4
2.4
2.6
2.3
u/field
0.09
11
66
58
654
0.86
0.49
1.3
1.4
—
—
—
0
0
258
2677
0.94
0.45
1.7
1.8
1.5
1.4
%
0.16
233
2389
78
680
1.13
0.44
1.4
1.4
—
—
—
0
0
224
2331
0.93
0.43
2.0
2.1
—
—
—
0
0
11
148
0.73
0.43
1.3
1.3
—
—
—
0
0
338
3152
1.06
0.41
2.5
2.7
145.1
106.0
ug/g
0.60
264
2522
8
57
1.37
0.41
6.1
2.2
—
—
—
0
0
21
164
1.25
0.40
1.2
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
5.5
—
—
—
0
0
103
920
1.10
0.40
1.7
1.8
—
—
—
0
0
5
34
1.44
0.39
1.0
1.1
—
—
—
0
0
20
156
1.26
0.39
1.5
1.8
—
—
—
0
0
8
60
1.31
0.39
1.0
1.1
—
—
—
0
0
8
60
1.31
0.39
1.0
1.1
—
—
—
0
0
38
318
1.17
0.39
1.6
1.4
16.0
19.0
u/l
0.32
29
272
21
165
1.25
0.39
1.2
1.2
—
—
—
0
0
17
130
1.28
0.38
1.0
1.2
—
—
—
0
0
46
392
1.15
0.38
2.8
3.6
36.9
39.0
mg/l
0.08
36
314
9
65
1.36
0.38
1.1
1.2
—
—
—
0
0
15
113
1.30
0.37
2.1
1.5
8.6
5.5
u/l
—
8
54
77
832
0.90
0.37
1.6
1.7
4.6
4.4
mg/l
0.04
45
572
37
311
1.17
0.36
1.0
1.0
-2.2
-2.4
mmol/l
0.10
11
72
322
3014
1.05
0.36
1.3
1.2
8.1
10.9
u/ml
0.31
113
1146
12
88
1.34
0.35
3.3
4.0
—
—
—
0
0
5
78
0.63
0.35
1.0
1.1
—
—
—
0
0
630
5990
1.04
0.35
1.4
1.5
0.9
2.4
u/ml
6.86
159
1373
19
228
0.81
0.34
1.9
1.4
—
—
—
0
0
140
1280
1.07
0.33
2.1
1.7
18.8
20.7
iu/l
0.33
110
969
94
846
1.09
0.33
1.4
1.3
190.1
231.1
miu/ml
0.54
38
418
25
206
1.19
0.32
1.0
1.1
—
—
—
0
0
98
886
1.09
0.31
1.2
1.2
—
—
—
0
0
15
182
0.81
0.31
2.2
2.2
—
—
—
0
0
7
52
1.32
0.30
1.1
1.5
—
—
—
0
0
35
299
1.15
0.30
1.3
1.8
—
1217.8
—
0
9
81
729
1.09
0.29
1.4
1.3
—
—
—
0
0
45
392
1.13
0.29
2.8
3.6
50.8
63.8
mg/l
0.31
35
313
83
748
1.09
0.29
1.5
1.6
—
—
—
0
0
113
1032
1.07
0.29
2.3
1.8
7.5
7.5
u/l
0.02
75
727
10
74
1.32
0.28
2.1
2.5
—
—
—
0
0
37
319
1.14
0.28
1.0
1.0
19.3
19.5
mmol/l
0.18
37
307
78
703
1.09
0.28
1.7
1.7
—
—
—
0
0
23
191
1.18
0.28
1.2
1.2
—
—
—
0
0
23
191
1.18
0.28
1.2
1.2
—
—
—
0
0
23
191
1.18
0.28
1.2
1.2
—
—
—
0
0
23
191
1.18
0.28
1.2
1.2
—
—
—
0
0
20
232
0.84
0.27
1.9
1.4
—
—
—
0
0
23
192
1.17
0.26
1.2
1.2
—
—
—
0
0
5
71
0.69
0.26
1.2
1.4
—
—
—
0
0
20
230
0.85
0.25
1.9
1.4
—
—
—
0
0
16
188
0.83
0.25
1.1
1.1
—
—
—
0
0
582
5563
1.03
0.25
3.7
3.6
7.5
7.9
mmol/l
0.92
504
4835
17
139
1.20
0.24
1.4
1.4
0.9
1.0
g/l
0.12
17
139
612
5859
1.03
0.24
1.8
1.8
—
—
—
0
0
6
82
0.72
0.24
1.7
2.3
157.3
149.2
nmol/l
—
6
72
20
227
0.86
0.22
1.9
1.4
—
—
—
0
0
36
316
1.12
0.22
1.1
1.1
8.0
7.7
iu/ml
—
8
57
18
150
1.18
0.22
1.1
1.2
—
—
—
0
0
18
150
1.18
0.22
1.1
1.2
91.7
80.1
%
0.73
18
150
20
226
0.86
0.22
1.9
1.4
—
—
—
0
0
20
226
0.86
0.22
1.9
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
11
87
1.24
0.21
1.3
1.2
—
—
—
0
0
0
13
0.00
0.20
0.0
3.5
—
—
—
0
0
0
14
0.00
0.20
0.0
3.3
—
142.1
—
0
9
0
14
0.00
0.20
0.0
8.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.9
—
—
—
0
0
0
14
0.00
0.20
0.0
5.9
—
—
—
0
0
6
50
1.17
0.19
1.2
1.1
—
—
—
0
0
13
150
0.85
0.18
12.5
14.2
876.1
806.7
nmol/l
0.21
13
145
106
1088
0.95
0.18
1.8
1.6
365.9
318.9
mu/l
0.65
99
981
31
275
1.10
0.17
1.2
1.4
6.4
7.2
mmol/l
0.57
23
197
10
80
1.22
0.17
1.9
1.6
26.6
17.1
nmol/l
—
5
23
35
314
1.09
0.16
6.0
3.5
1.5
1.5
mmol/l
0.07
35
304
68
628
1.06
0.16
1.4
1.5
—
—
—
0
0
9
77
1.14
0.15
3.7
6.8
—
—
—
0
0
9
77
1.14
0.15
4.8
7.0
—
—
—
0
0
12
137
0.86
0.15
4.4
3.2
58.2
144.2
umol/l
—
6
38
189
1904
0.97
0.14
1.8
2.0
—
—
—
0
0
152
1537
0.97
0.14
1.4
1.5
—
—
—
0
0
18
156
1.13
0.14
1.1
1.8
—
—
—
0
0
253
2417
1.03
0.14
2.8
2.7
0.8
0.7
ug/l
0.29
153
1448
12
101
1.16
0.13
1.5
1.7
—
1428581.3
—
0
8
190
1908
0.97
0.13
1.7
1.6
—
—
—
0
0
1670
16269
1.01
0.10
3.5
3.5
—
—
—
0
0
5
44
1.11
0.10
1.0
1.1
—
—
—
0
0
13
142
0.90
0.09
1.3
1.5
—
—
—
0
0
5
46
1.06
0.09
1.0
1.1
—
—
—
0
0
43
400
1.05
0.09
1.7
1.5
0.5
0.3
nmol/l
0.41
35
325
15
133
1.10
0.08
1.0
1.5
—
—
—
0
0
31
286
1.06
0.08
6.3
3.4
6.8
7.3
mmol/l
0.39
31
278
7
65
1.05
0.08
7.6
8.5
—
—
—
0
0
41
383
1.05
0.07
4.4
3.4
29.2
23.7
mg/l
0.39
35
240
6
71
0.83
0.07
1.0
1.0
—
—
—
0
0
8
76
1.03
0.07
1.4
1.2
—
—
—
0
0
9
85
1.04
0.07
1.2
1.3
—
74.5
—
0
11
8
90
0.87
0.06
1.4
1.2
—
—
—
0
0
40
408
0.96
0.06
1.5
1.4
—
—
—
0
0
327
3232
0.99
0.06
1.5
1.5
—
—
—
0
0
427
4212
0.99
0.06
4.0
3.6
1.0
1.0
kg/l
0.32
57
682
15
157
0.93
0.04
1.6
1.3
53.2
240.9
pmol/l
—
6
50
65
650
0.98
0.04
1.4
1.5
—
—
—
0
0
69
688
0.98
0.03
1.1
1.1
0.6
7.4
u/ml
2.53
11
97
336
3267
1.01
0.03
3.7
3.8
21.9
21.1
%
0.37
142
1389
19
195
0.95
0.03
1.1
1.4
2.0
0.7
u/ml
—
5
66
53
508
1.02
0.02
1.0
1.1
—
—
—
0
0
12
125
0.94
0.02
1.1
1.0
—
—
—
0
0
28
266
1.03
0.02
4.1
2.7
757.4
747.3
e6/l
—
8
56
21
212
0.97
0.01
3.4
3.9
55.3
96.6
u/ml
—
6
59
14
131
1.05
0.01
1.0
1.0
—
—
—
0
0
41
407
0.99
0.00
1.5
1.5
97.6
173.5
pmol/l
0.87
41
396
13
123
1.03
0.00
1.5
1.8
—
—
—
0
0
37
358
1.01
0.00
2.8
2.5
85.5
124.2
ug/min
0.29
20
228
140
1370
1.00
0.00
1.2
1.4
—
—
—
0
0
29
282
1.01
0.00
1.9
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
11.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
1266.0
—
0
8
6
58
1.01
0.00
1.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
30.8
—
0
5
6
66
0.89
0.00
2.3
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
57
0.86
0.00
1.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
4.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
8.0
—
0
9
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
4.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint Q17_SEPTA_DEFEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_SEPTA_DEFEC | 1.871 [1.6, 2.18] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 678 out of 17245 females with Q17_SEPTA_DEFEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| Q17_SEPTA_DEFEC | 1.71 [1.44, 2.03] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 575 out of 15035 males with Q17_SEPTA_DEFEC died.
Mortality risk
Mortality risk for people of age
years, who have Q17_SEPTA_DEFEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.134% | 0.217% |
| 5 | 0.916% | 1.639% |
| 10 | 2.426% | 4.085% |
| 15 | 4.574% | 7.915% |
| 20 | 7.682% | 12.977% |
Relationships between endpoints
↥Index endpoint: Q17_SEPTA_DEFEC – Septal defects
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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