Ulcerative rectosigmoiditis

ULCERRECT

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K51.3
  • Cause of death: ICD-10 K51.3

2 out of 7 registries used, show all original rules.

3609

4. Check minimum number of events

None

3609

5. Include endpoints

None

3609

6. Filter based on genotype QC (FinnGen only)

3511

Control definitions (FinnGen only)

Control exclude
K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K51
Name in latin
Rectosigmoiditis ulcerosa [chronica]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19206 8881 10235
Only index persons 18415 8651 9764
Unadjusted period prevalence (%)
Whole population 0.27 0.25 0.29
Only index persons 0.35 0.32 0.37
Median age at first event (years)
Whole population 44.63 42.34 46.50
Only index persons 43.93 41.94 45.70

-FinnGen-

Key figures

All Female Male
Number of individuals 3511 1810 1701
Unadjusted period prevalence (%) 0.71 0.64 0.78
Median age at first event (years) 45.55 41.95 49.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
3609
Matched controls
36090
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A07EA01
ATC
prednisolone; oral, rectal
953.4
307.7
422
5
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
76.4
307.7
269
38
A07EC01
ATC
sulfasalazine; oral, rectal
10.4
307.7
1001
1290
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.1
307.7
1616
5945
K51
ICD-10 Finland
Ulcerative colitis
1493.7
307.7
719
6
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
6114.8
307.7
2111
7
L01BB02
ATC
mercaptopurine; oral
254.7
307.7
578
27
K51.5
ICD-10 Finland
Left sided colitis
9965.6
307.7
2215
5
A07EC02
ATC
mesalazine; oral, rectal
5321.0
307.7
3421
123
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
2054.6
307.7
1131
8
A07EA06
ATC
budesonide; oral, local oral
275.1
307.7
1590
103
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
14.9
307.7
1169
1122
L04AB02
ATC
infliximab; parenteral
175.5
307.7
199
12
L04AX01
ATC
azathioprine; systemic
79.0
307.7
1548
340
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
307.7
714
*
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
+∞
307.7
3609
*
H02AB06
ATC
prednisolone; systemic
8.8
307.7
2913
11592
A07EA02
ATC
hydrocortisone; rectal
703.9
307.7
1801
51
K51.8
ICD-10 Finland
Other ulcerative colitis
5776.4
307.7
902
*
UJF30
NOMESCO Finland
Ileoscopy through colon
19.2
307.7
1603
1441
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
33.0
307.7
424
145
H02AB07
ATC
prednisone; oral
6.5
307.7
1119
2331
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
307.7
525
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
307.7
504
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
307.7
3385
*
UJF32
NOMESCO Finland
Coloscopy
29.1
307.7
2920
4584
D94
ICPC
Chronic enteritis/ulcerative colitis
290.8
307.7
366
14
K50.8
ICD-10 Finland
Other Crohn disease
+∞
291.7
276
*
K50.1
ICD-10 Finland
Crohn disease of large intestine
1531.5
291.5
280
*
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
37.7
272.7
169
47
K50.9
ICD-10 Finland
Crohn disease, unspecified
928.2
267.1
259
*
ZX120
NOMESCO Finland
Intravenous
4.9
252.8
641
1531
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
343.2
252.7
253
8
L04AC05
ATC
ustekinumab; parenteral
55.6
236.7
134
25
L04AB04
ATC
adalimumab; parenteral
10.3
233.5
269
280
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
224.3
213
*
A07EC03
ATC
olsalazine; oral
+∞
194.6
185
*
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
34.8
186.6
118
35
J01MA02
ATC
ciprofloxacin; systemic
2.7
183.8
1705
8955
4AA12, ,
NOMESCO Finland
81.3
178.5
95
12
4AB02, ,
NOMESCO Finland
51.4
173.9
100
20
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
+∞
169.1
161
*
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
167.0
159
*
P01AB01
ATC
metronidazole; oral, rectal
2.6
163.0
1752
9725
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
+∞
154.3
147
*
3042, ,
Kela drug reimbursment
+∞
147.9
141
*
253, ,
Kela drug reimbursment
+∞
147.9
141
*
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
693.9
136.7
134
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
132.3
971
4410
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
126.4
1164
5865
L04AA33
ATC
[U] vedolizumab
+∞
120.5
115
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.5
119.0
1022
4967
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
312.7
118.9
120
*
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
+∞
112.1
107
*
L04AG05
ATC
vedolizumab; parenteral
+∞
111.0
106
*
3005
Kela drug reimbursment
Tofacitinib
24.9
110.6
78
32
K62.8
ICD-10 Finland
Other specified diseases of anus and rectum
14.0
110.2
102
75
L04AD01
ATC
ciclosporin; systemic
7.3
110.0
165
236
Z93.2
ICD-10 Finland
Ileostomy status
43.4
107.1
64
15
1370
FHL
Colonoscopy, whole colon
33.0
105.9
68
21
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
4.1
104.8
310
814
L04AB06
ATC
golimumab; parenteral
11.8
104.4
107
93
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
+∞
102.6
98
*
C05AA08
ATC
fluocortolone; rectal, topical
2.7
92.5
597
2503
K83.0
ICD-10 Finland
Cholangitis
9.0
87.9
109
124
L04AA29
ATC
[U] tofacitinib
20.1
87.1
67
34
UJF92
NOMESCO Finland
Capsular endoscopy
7.1
86.5
132
192
256, ,
Kela drug reimbursment
+∞
85.8
82
*
WX002
NOMESCO Finland
Sedation and analgesia
2.3
85.1
754
3650
A07DA03
ATC
loperamide; oral
5.2
83.8
178
358
A02BC02
ATC
pantoprazole; systemic
2.0
83.4
2472
18605
JFF10
NOMESCO Finland
Loop enterostomy
15.8
81.3
70
45
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
+∞
80.5
77
*
JFG20
NOMESCO Finland
Closure of enterostomy with resection of exteriorised loop
16.1
79.6
68
43
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
31.0
79.4
52
17
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.2
76.5
784
4014
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
5.4
75.2
153
296
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.5
75.0
271
813
C10AC01
ATC
colestyramine; oral
5.6
74.0
143
264
A07AA09
ATC
vancomycin; oral
8.2
73.5
98
122
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
72.6
1573
10477
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.5
69.4
250
748
UJF34
NOMESCO Finland
Left colonoscopy
14.2
69.1
63
45
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
67.9
65
*
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
+∞
67.9
65
*
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
16.7
66.9
56
34
WVA20
NOMESCO Finland
Medicine administration
4.8
65.6
153
333
JF1BD
NOMESCO Finland
Very extensive small bowel CT
23.8
65.5
47
20
JFH10
NOMESCO Finland
Total colectomy and ileostomy
136.5
63.1
67
5
JFH11
NOMESCO Finland
Laparoscopic colectomy
+∞
61.6
59
*
H02AB09
ATC
hydrocortisone; systemic
4.8
61.5
143
310
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
61.4
400
1666
A05AA02
ATC
ursodeoxycholic acid; oral
5.8
61.1
113
200
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
59.5
57
*
K92.1
ICD-10 Finland
Melaena
3.5
59.4
213
635
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
59.2
385
1602
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.2
58.9
591
2971
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.7
58.8
194
547
JFH20
NOMESCO Finland
Proctocolectomy and ileostomy
+∞
58.5
56
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.1
58.2
123
246
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.1
57.7
253
853
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
13.5
55.4
52
39
L04AX03
ATC
methotrexate; systemic
2.4
54.5
405
1791
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
53.3
51
*
H02AB04
ATC
methylprednisolone; systemic
2.2
52.9
538
2711
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.8
52.4
276
1030
4AA33, ,
NOMESCO Finland
+∞
51.2
49
*
D16
ICPC
Rectal bleeding
4.5
51.1
128
295
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
6.0
50.8
91
156
UJG02
NOMESCO Finland
Proctoscopy
4.6
48.9
118
264
UJF30, ,
SPAT
7.2
45.3
67
94
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.2
44.6
411
1985
L04AA01
ATC
[U] ciclosporin
5.7
43.1
80
142
Z93
ICD-10 Finland
Artificial opening status
16.1
40.9
35
22
3AC01, ,
NOMESCO Finland
6.9
40.7
63
93
M45
ICD-10 Finland
Ankylosing spondylitis
3.9
39.6
117
305
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
39.5
798
5018
A02BC03
ATC
lansoprazole; oral
1.7
39.2
926
6077
M09.2*K51.9
ICD-10 Finland
Juvenile arthritis in ulcerative colitis
+∞
38.6
37
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.0
37.9
460
2458
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
37.3
395
2008
K50
ICD-10 Finland
Crohn disease [regional enteritis]
131.4
36.8
39
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
36.7
1251
8981
56902
ICD-8 Finland
Other diseases of intestines and peritoneum, Proctitis haemorrhagica (ulcerosa)
+∞
35.5
34
*
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
35.5
34
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
35.3
461
2522
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
4.9
34.9
77
160
JF1AD
NOMESCO Finland
Small bowel CT
10.1
34.5
39
39
N02AX02
ATC
tramadol; systemic, rectal
1.6
34.3
1400
10434
D18
ICPC
Change in faeces/bowel movements
3.7
34.3
111
309
TJF80
NOMESCO Finland
Ostomy education
6.0
34.2
60
101
L01BA01
ATC
methotrexate; systemic
3.1
33.8
146
487
N02BE01
ATC
paracetamol; systemic, rectal
1.8
33.6
3084
27609
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.6
33.1
196
775
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
4.5
32.7
81
185
A02BC01
ATC
omeprazole; systemic
1.6
32.5
849
5681
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
+∞
31.3
30
*
JAH00
NOMESCO Finland
Laparotomy
3.5
30.8
107
312
A02BC05
ATC
esomeprazole; systemic
1.5
30.5
1321
9905
K60.3
ICD-10 Finland
Anal fistula
3.9
30.4
91
240
R50.9
ICD-10 Finland
Fever, unspecified
1.8
30.2
509
3013
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
3.8
28.8
87
231
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.6
27.4
161
634
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
10.8
26.9
29
27
XX6XT
NOMESCO Finland
Other intravascular therapy with radiological guidance
9.8
26.8
31
32
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.5
26.5
1495
11732
ZXC86
NOMESCO Finland
Use of endoscopic device
7.2
26.3
39
55
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
6.1
26.3
45
74
B01AB05
ATC
enoxaparin; parenteral
1.5
26.1
924
6586
N02AJ06
ATC
codeine and paracetamol; systemic
1.5
25.9
1442
11272
C05AA01
ATC
hydrocortisone; rectal, topical
2.5
25.9
172
718
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.6
25.7
665
4407
WW200
NOMESCO Finland
Immunization
3.0
25.5
115
394
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.1
25.5
240
1163
K56.7
ICD-10 Finland
Ileus, unspecified
4.5
25.2
62
141
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
4.5
25.2
61
137
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.4
24.6
90
272
A03CA02
ATC
clidinium and psycholeptics; oral
2.4
24.4
167
707
L04AF03
ATC
upadacitinib; oral
24.5
24.3
34
14
JHA00
NOMESCO Finland
Anal or perianal incision
3.8
24.2
73
194
5586X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis[KROONINEN INFLAMMATOORINEN SUOLISTOSAIRAUS, NUD]
+∞
24.0
23
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
3.2
23.9
93
292
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.9
23.2
322
1788
UJF02
NOMESCO Finland
Peroral enteroscopy
8.0
23.0
31
39
JF2AB
NOMESCO Finland
Colongraphy with X-ray
18.6
23.0
35
19
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
3.4
22.4
80
238
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.1
22.2
93
305
J01MA12
ATC
levofloxacin; systemic
1.6
22.2
547
3569
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
4.9
22.2
49
102
JGB40
NOMESCO Finland
Excision of rectum and end ileostomy
+∞
21.9
21
*
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
2.4
21.6
155
670
D06BX01
ATC
metronidazole; topical
1.8
21.6
350
2039
ZXE20
NOMESCO Finland
More than three and less than five hours
1.7
21.5
407
2479
SPAT1263
SPAT
Sampling
1.4
21.5
1311
10326
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.0
21.4
97
333
1490
FHL
Sigmoideoscopy (fiberscope)
19.0
21.2
32
17
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.0
21.1
223
1128
K61.0
ICD-10 Finland
Anal abscess
3.3
20.7
77
235
A06AC51
ATC
ispaghula, combinations; oral
2.3
20.1
150
660
Z43.2
ICD-10 Finland
Attention to ileostomy
27.2
20.0
27
10
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
3.0
19.9
86
288
1380
FHL
Colonoscopy, left side
+∞
19.8
19
*
56399
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Other
+∞
19.8
19
*
JHW96
NOMESCO Finland
Other operation on anus or perianal tissue
6.9
19.5
30
44
ZXE00
NOMESCO Finland
One hour or less
1.4
19.4
1212
9543
SPAT1131
SPAT
Colonoscopy
2.8
19.3
100
370
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
18.8
1207
9535
JFG40
NOMESCO Finland
Revision of enterostomy or colostomy without laparotomy
15.1
18.4
30
20
K91.4
ICD-10 Finland
Colostomy and enterostomy malfunction
17.6
18.2
28
16
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.8
18.2
266
1500
D11
ICPC
Diarrhoea
1.7
18.2
395
2491
-, ,
ICD-10 Finland
2.9
17.9
81
279
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.9
17.8
216
1147
JFF13
NOMESCO Finland
Terminal enterostomy
14.6
17.6
29
20
K56.0
ICD-10 Finland
Paralytic ileus
4.9
17.5
38
78
298, ,
Kela drug reimbursment
13.1
17.4
30
23
WZC30
NOMESCO Finland
Teaching
1.6
17.2
468
3115
SPAT1262
SPAT
Handing over of treatment supplies
1.6
17.1
489
3292
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
3.6
17.1
55
153
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
2.3
17.1
125
546
3029
Kela drug reimbursment
Upadacitinib
12.6
17.1
30
24
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
2.7
17.1
92
348
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
16.6
1208
9694
JHD00
NOMESCO Finland
Anal dilatation
4.8
16.6
37
78
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.2
16.5
133
606
J01DB01
ATC
cefalexin; oral
1.4
16.2
2817
25803
Z2221
NOMESCO Finland
Medical doctor
1.4
16.2
839
6357
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.4
16.2
976
7591
L04AF01
ATC
tofacitinib; oral
21.0
16.0
23
11
E0000UV, ,
ATC
1.4
15.8
1281
10432
J01FA10
ATC
azithromycin; systemic
1.3
15.8
1937
16769
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
2.6
15.8
91
356
D99
ICPC
Disease digestive system other
4.1
15.7
43
107
JFB00
NOMESCO Finland
Partial resection of small intestine
3.8
15.6
47
125
UJF32, ,
SPAT
2.5
15.5
94
377
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.9
15.5
209
1149
M05BA04
ATC
alendronic acid; oral
2.0
15.4
180
943
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
3.3
15.4
58
179
WX408
NOMESCO Finland
General anesthesy, balanced
1.4
15.4
765
5746
D07AC01
ATC
betamethasone; topical
1.4
15.3
1094
8728
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
14.9
1322
10886
JHD20
NOMESCO Finland
Incision of fistula-in-ano
3.8
14.9
45
120
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
4.7
14.9
34
73
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.7
14.9
278
1684
WX402
NOMESCO Finland
General anaesthesia
1.4
14.7
656
4828
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.6
14.6
323
2043
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
6.4
14.5
24
38
K52.1
ICD-10 Finland
Toxic gastroenteritis and colitis
150.6
14.5
15
*
JFA38
NOMESCO Finland
Endoscopic dilatation of small intestine
150.6
14.5
15
*
A03BA03
ATC
hyoscyamine; oral
4.7
14.5
33
71
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
5.8
14.4
26
45
R01AD12
ATC
fluticasone furoate; nasal
1.4
14.3
1049
8382
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
2.7
14.3
73
269
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.7
14.2
254
1519
A02BA02
ATC
ranitidine; systemic
1.5
14.1
501
3529
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
3.9
14.0
41
107
R01AD08
ATC
fluticasone; nasal
1.4
14.0
924
7263
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
2.2
14.0
115
529
A98
ICPC
Health maint/preventive medicine
2.0
14.0
3468
33427
UJD02
NOMESCO Finland
Gastroscopy
2.1
13.8
131
638
J05AB01
ATC
aciclovir; systemic
1.4
13.6
637
4723
6419
FHL
Other measure in this category
34.1
13.5
17
5
UJH02
NOMESCO Finland
Anoscopy
2.1
13.4
126
611
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
3.3
13.4
50
154
M13.9
ICD-10 Finland
Arthritis, unspecified
1.7
13.3
227
1340
Y0599
ICD-8 Finland
Investigation of digestive system
3.2
13.3
52
165
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.9
13.1
167
902
K59.1
ICD-10 Finland
Functional diarrhoea
2.0
13.0
146
755
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
13.0
523
3767
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
11.0
13.0
24
22
JFA58
NOMESCO Finland
Endoscopic dilatation of colon
16.8
13.0
20
12
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
2.3
12.9
100
449
Z3231
NOMESCO Finland
Registered nurse
1.4
12.8
779
6031
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.9
12.8
37
96
SPAT1325
SPAT
Vaccination
1.4
12.7
860
6771
D29
ICPC
Digestive symptom/complaint other
2.5
12.7
79
322
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
2.2
12.6
103
473
SPAT1301
SPAT
No procedures
1.4
12.6
856
6741
Z01.2
ICD-10 Finland
Dental examination
1.3
12.3
1453
12352
JGA05
NOMESCO Finland
Endoscopic polypectomy in rectum
5.4
12.3
24
45
SPAT1153
SPAT
Removal of sutures
1.3
12.2
861
6812
J05AB11
ATC
valaciclovir; oral
1.5
12.2
409
2841
UJK02
NOMESCO Finland
ERCP
2.5
12.2
72
286
SPAT1255
SPAT
Intravenous administration of medicine
1.8
12.1
188
1081
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
10.1
12.0
23
23
WZA90
NOMESCO Finland
Other medical or dental certificate
1.4
11.9
705
5425
K55.9
ICD-10 Finland
Vascular disorder of intestine, unspecified
13.4
11.9
20
15
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.7
11.9
232
1421
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.2
11.9
101
472
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
2.9
11.7
55
194
A07AA02
ATC
nystatin; oral
1.9
11.7
148
798
L04AA44
ATC
[U] upadacitinib
9.6
11.7
23
24
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.4
11.7
81
347
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.8
11.6
166
932
SPAT1125
SPAT
Stoma care and guidance
3.4
11.5
40
118
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
11.5
1677
14605
N03AX16
ATC
[U] pregabalin
1.4
11.5
649
4957
H15.1
ICD-10 Finland
Episcleritis
2.9
11.5
54
191
JGB61
NOMESCO Finland
Laparoscopic excision of rectum and ileoanal anastomosis
+∞
11.5
11
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
11.3
296
1948
B80
ICPC
Iron deficiency anaemia
2.4
11.3
73
303
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.4
11.3
655
5023
K74.3
ICD-10 Finland
Primary biliary cirrhosis
4.7
11.2
25
53
J01AA02
ATC
doxycycline; systemic
1.3
11.1
2485
22772
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.6
11.0
278
1816
ZXD05
NOMESCO Finland
Urgent procedure
1.3
11.0
909
7345
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
10.9
2238
20258
L88
ICPC
Rheumatoid/seropositive arthritis
2.0
10.8
113
571
UJK12
NOMESCO Finland
Peroral cholangioscopy
11.9
10.8
19
16
J01CA04
ATC
amoxicillin; systemic
1.3
10.8
2766
25743
J02AC01
ATC
fluconazole; systemic
1.3
10.8
1160
9703
NA6CG
NOMESCO Finland
Sacro-iliac joint extensive MRI examination with high intensity magnet
4.9
10.7
23
47
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
3.0
10.6
45
150
TPH07
NOMESCO Finland
Cathetrisation of artery
1.6
10.6
277
1822
K76.9
ICD-10 Finland
Liver disease, unspecified
3.1
10.6
44
145
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.4
10.6
618
4740
B03BA03
ATC
hydroxocobalamin; parenteral
1.9
10.6
122
639
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
10.6
2419
22147
L88
ICD-10 Finland
Pyoderma gangrenosum
11.2
10.5
19
17
3048, ,
Kela drug reimbursment
+∞
10.4
10
*
L04AA45
ATC
[U] filgotinib
+∞
10.4
10
*
255, ,
Kela drug reimbursment
+∞
10.4
10
*
B02.9
ICD-10 Finland
Zoster without complication
1.8
10.3
161
927
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
10.3
1127
9435
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
3.2
10.3
39
122
WZC00
NOMESCO Finland
Treatment plan or consultation
1.3
10.2
1079
8996
NH3EA
NOMESCO Finland
Feet X-ray examination with load
2.5
10.0
60
241
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
1.7
9.8
183
1109
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
9.7
2359
21624
UKC02
NOMESCO Finland
Cystoscopy
1.4
9.7
384
2755
JFG50
NOMESCO Finland
Laparotomy with revision of enterostomy or colostomy
55.1
9.6
11
*
R03AC02
ATC
salbutamol; inhalant
1.2
9.6
1715
15176
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
1.9
9.6
110
576
J01MA01
ATC
ofloxacin; systemic
1.6
9.5
207
1305
S18
ICPC
Laceration/cut
1.3
9.5
1286
11026
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
9.4
996
8283
5589X
ICD-9 Finland
Other non-infective gastro-enteritis and colitis, Other and unspecified non-infectious gastro-enteritis and colitis
+∞
9.4
9
*
5551A
ICD-9 Finland
Regional enteritis, Large intestine
+∞
9.4
9
*
6410
FHL
Panprococolectomy and ileostomy
+∞
9.4
9
*
56300
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Regional enteritis
+∞
9.4
9
*
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
2.8
9.4
46
167
JAH01
NOMESCO Finland
Laparoscopy
1.8
9.3
125
689
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
9.3
564
4345
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.5
9.1
307
2135
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
2.5
9.0
56
229
K60.4
ICD-10 Finland
Rectal fistula
10.0
9.0
17
17
SPAT1138
SPAT
Guidance concerning bowel function
2.9
9.0
40
138
SFA10
NOMESCO Finland
One-surface restoration
1.2
8.9
1772
15810
D07AB02
ATC
hydrocortisone butyrate; topical
1.3
8.9
840
6882
N05CF01
ATC
zopiclone; oral
1.3
8.9
860
7068
TJJ00
NOMESCO Finland
Percutaneous needle biopsy of liver
8.0
8.8
19
24
R05
ICPC
Cough
1.3
8.7
661
5262
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
8.6
1686
15003
Z01.9
ICD-10 Finland
Special examination, unspecified
1.7
8.5
155
936
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.4
8.4
358
2600
B01AB10
ATC
tinzaparin; parenteral
1.5
8.4
248
1678
SPAT1260
SPAT
Consultation of another employee
1.4
8.4
458
3468
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
8.4
838
6906
E86
ICD-10 Finland
Volume depletion
2.4
8.3
57
244
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
+∞
8.3
8
*
5563A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctosigmoiditis
+∞
8.3
8
*
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
8.3
8
*
JFH31
NOMESCO Finland
Laparoscopic total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
+∞
8.3
8
*
K62.6
ICD-10 Finland
Ulcer of anus and rectum
3.1
8.3
34
112
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
8.3
1499
13210
I84.1
ICD-10 Finland
Internal hemorrhoids with other complications
2.2
8.2
64
290
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
2.5
8.2
49
197
B81
ICPC
Anaemia vit B12/folate deficiency
2.0
8.2
80
396
K76.0
ICD-10 Finland
Fatty (change of) liver, not elsewhere classified
2.0
8.2
87
444
D07AC13
ATC
mometasone; topical
1.3
8.1
829
6850
D07AD01
ATC
clobetasol; topical
1.4
8.1
444
3367
N82.3
ICD-10 Finland
Fistula of vagina to large intestine
22.1
8.0
11
5
6451
FHL
Dilatation
3.6
8.0
25
69
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.6
8.0
185
1186
H26.3
ICD-10 Finland
Drug-induced cataract
3.9
8.0
23
60
H04.10
ICD-10 Finland
Dry eye syndrome
1.4
7.9
299
2124
ZXD10
NOMESCO Finland
Scheduled procedure
1.2
7.9
1045
8889
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.6
7.9
174
1102
M25.5
ICD-10 Finland
Pain in joint
1.3
7.9
953
8026
K91.8
ICD-10 Finland
Other postprocedural disorders of digestive system, not elsewhere classified
13.0
7.9
13
10
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.5
7.8
229
1546
R51.80
ICD-10 Finland
Headache
1.4
7.8
452
3451
D17
ICPC
Incontinence of bowel
3.6
7.8
25
70
A07AA11
ATC
rifaximin; oral
6.1
7.8
20
33
M01AH01
ATC
celecoxib; oral
1.4
7.8
438
3331
I80.0
ICD-10 Finland
Phlebitis and thrombophlebitis of superficial vessels of lower extremities
1.9
7.7
94
503
K52.80
ICD-10 Finland
(Hemorrhagic) colitis caused by antibiotics
45.1
7.7
9
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
2.1
7.7
66
312
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.3
7.6
480
3715
SFA20
NOMESCO Finland
Two-surface restoration
1.2
7.6
1915
17390
E000001, ,
ATC
1.3
7.6
555
4386
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.5
7.6
82
1513
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
1.7
7.5
123
721
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
2.6
7.4
40
153
K02.1
ICD-10 Finland
Caries of dentine
1.2
7.4
1943
17691
K29.3
ICD-10 Finland
Chronic superficial gastritis
2.0
7.4
75
377
Z71.8
ICD-10 Finland
Other specified counselling
1.2
7.4
909
7662
M81.4
ICD-10 Finland
Drug-induced osteoporosis
6.0
7.4
19
32
SPAT1312
SPAT
General health counselling
1.3
7.4
888
7469
K25.9
ICD-10 Finland
Gastric ulcer, Unspecified as acute or chronic, without haemorrhage or perforation
2.6
7.3
41
160
H20.1
ICD-10 Finland
Chronic iridocyclitis
2.9
7.3
33
115
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
2.0
7.3
77
393
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.3
7.3
462
3577
R01AD09
ATC
mometasone; nasal
1.2
7.3
1428
12636
D62
ICPC
Digestive, Administrative procedure
4.1
7.3
19
46
M01AE01
ATC
ibuprofen; systemic, rectal
0.8
7.2
2865
29949
TDM10
NOMESCO Finland
Puncture of maxillary antrum
1.8
7.2
112
647
K30
ICD-10 Finland
Functional dyspepsia
1.4
7.1
302
2192
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.5
7.1
248
1738
L02.3
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of buttock
2.0
7.1
68
336
ZYC01
NOMESCO Finland
Remote contact by phone
1.6
7.1
168
1085
S02.51
ICD-10 Finland
Fracture of tooth, open
1.4
7.0
262
1859
JG1JB
NOMESCO Finland
Defekography with X-ray
3.5
7.0
23
66
A01AB09
ATC
miconazole; local oral
1.5
7.0
199
1339
K63.9
ICD-10 Finland
Disease of intestine, unspecified
4.4
7.0
17
39
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
1.9
6.8
85
459
L95
ICPC
Osteoporosis
2.0
6.8
66
327
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
2.3
6.8
50
222
D07AB08
ATC
desonide; topical
1.4
6.8
282
2040
JFH00
NOMESCO Finland
Total colectomy and ileorectal anastomosis
9.3
6.8
13
14
SCA02
NOMESCO Finland
Preventive oral health care
1.4
6.8
282
2041
J01MA14
ATC
moxifloxacin; systemic
1.5
6.8
232
1620
M03BC51
ATC
orphenadrine, combinations; systemic
1.2
6.8
791
6622
JEA01
NOMESCO Finland
Laparoscopic appendectomy
1.7
6.7
115
683
D04
ICPC
Rectal/anal pain
2.4
6.7
42
174
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.4
6.6
345
2591
D82
ICPC
Teeth/gum disease
1.2
6.6
1150
10030
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
1.7
6.6
106
619
D07XC01
ATC
betamethasone; topical
1.4
6.6
318
2360
J01DA01
ATC
[U] cefalexin
1.2
6.6
1915
17526
5781B
ICD-9 Finland
Gastro-intestinal haemorrhage, Melaena[HAEMORRHAGIA EX ANO]
8.7
6.5
13
15
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
6.5
501
3986
OAB50, ,
SPAT
1.6
6.5
137
862
M03BX02
ATC
tizanidine; oral
1.2
6.4
1997
18362
JHA20
NOMESCO Finland
Excision of lesion of anal canal or perianal tissue
2.6
6.4
36
141
KMAK, ,
NOMESCO Finland
1.2
6.4
1663
15043
M05BA07
ATC
risedronic acid; oral
2.1
6.4
54
254
L52
ICD-10 Finland
Erythema nodosum
3.3
6.4
23
70
JD1AB
NOMESCO Finland
Gastro-duodenography with X-ray
14.3
6.4
10
7
M54.5
ICD-10 Finland
Low back pain
1.2
6.4
1062
9217
J31.0
ICD-10 Finland
Chronic rhinitis
1.4
6.4
236
1673
A99
ICPC
Disease/condition unspecnature/site
1.4
6.4
230
1623
K29.0
ICD-10 Finland
Acute haemorrhagic gastritis
4.1
6.3
17
42
J45.1
ICD-10 Finland
Nonallergic asthma
1.5
6.3
176
1178
N06AX11
ATC
mirtazapine; oral
1.2
6.3
955
8207
Z94.4
ICD-10 Finland
Liver transplant status
5.5
6.3
17
31
R11
ICD-10 Finland
Nausea and vomiting
1.5
6.3
209
1453
DM1AI, ,
SPAT
2.8
6.3
29
103
1CB02, ,
NOMESCO Finland
+∞
6.2
6
*
M073, K519,
ICD-10 Finland
+∞
6.2
6
*
K52.0
ICD-10 Finland
Gastroenteritis and colitis due to radiation
+∞
6.2
6
*
G04CA02
ATC
tamsulosin; oral
1.3
6.2
543
4386
R05
ICD-10 Finland
Cough
1.3
6.2
563
4569
JFG96
NOMESCO Finland
Other operation on intestinal stoma or pouch
26.7
6.2
8
*
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
2.6
6.2
33
126
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
1.6
6.2
135
855
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.2
6.2
803
6790
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.4
6.2
293
2168
SCA01
NOMESCO Finland
Preventive oral health care, short
1.2
6.2
851
7241
SPAT1104
SPAT
Monitoring of emergency patient
1.6
6.2
155
1015
JHD33
NOMESCO Finland
Completing incision of fistula-in-ano
6.3
6.2
15
24
ZXE30
NOMESCO Finland
More than five and less than seven hours
1.7
6.1
113
686
A02BA04
ATC
nizatidine; systemic
1.5
6.1
160
1057
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.5
6.1
208
1451
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
1.6
6.1
136
868
M02AA07
ATC
piroxicam; topical
1.2
6.1
918
7888
E000006, ,
ATC
1.5
6.0
158
1044
D64.9
ICD-10 Finland
Anaemia, unspecified
1.5
6.0
212
1488
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.5
6.0
165
1101
D01
ICPC
Abdominal pain/cramps general
1.4
6.0
303
2264
-60
ICPC
Result test/procedure
1.6
6.0
142
917

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
860
2168
4.89
322.31
6.2
4.2
0.71
0.92
%
1.20
236
721
834
2074
4.93
317.48
6.3
4.2
0.05
0.10
%
1.46
207
627
402
481
9.28
315.71
4.8
3.2
3.89
4.08
e9/l
0.85
402
481
406
498
9.06
312.59
5.0
3.4
56.89
57.01
%
0.06
406
498
816
1951
5.11
307.65
6.2
4.3
0.06
0.42
%
0.91
185
512
3380
21344
10.20
307.65
17.0
6.8
72.19
76.28
u/l
9.64
3320
20214
2787
10906
7.83
307.65
9.0
4.6
36.92
36.05
g/l
18.49
2703
10169
2885
14570
5.89
307.65
13.3
5.6
1.87
1.96
e9/l
3.06
2713
13000
2827
2920
41.07
307.65
7.5
1.3
232.61
89.18
ug/g
42.04
2704
2256
2280
2464
23.41
307.65
2.1
1.2
—
—
—
0
0
824
1979
5.10
307.65
5.8
4.0
0.39
0.74
%
5.01
213
625
340
46
81.50
307.65
2.7
2.3
151.55
187.61
au/ml
—
49
9
2649
13525
4.60
307.65
12.6
5.5
56.90
56.74
%
0.35
2558
12769
2447
10939
4.84
307.65
3.6
2.1
76.32
75.25
nmol/l
1.19
2356
9984
2964
16313
5.57
307.65
14.8
8.8
3.89
4.07
e9/l
5.03
2762
14308
2636
13169
4.72
307.65
13.3
5.7
2.86
2.84
%
0.24
2546
12388
2669
13717
4.63
307.65
13.4
5.7
28.80
28.57
%
0.57
2577
12964
392
44
99.83
307.65
3.2
2.4
8.18
5.35
mg/l
3.67
334
32
2796
13228
5.94
307.65
14.9
6.0
—
—
—
0
0
2592
12734
4.67
307.65
13.4
5.7
0.75
0.67
%
14.77
2495
11947
2906
14635
6.06
307.65
13.3
5.8
0.19
0.19
e9/l
0.70
2720
12953
2872
14093
6.08
307.65
13.2
5.5
0.56
0.57
e9/l
1.90
2678
12288
2872
14116
6.07
307.65
13.2
5.5
0.04
0.04
e9/l
3.46
2680
12293
2651
13260
4.76
307.65
13.7
5.9
8.71
8.45
%
4.60
2561
12493
1582
6369
3.64
306.35
3.7
2.0
2.79
2.85
mg/l
0.51
1447
5430
3115
20870
4.60
243.07
7.5
3.7
11.19
10.60
mm/h
1.83
2962
19454
160
56
29.85
240.88
2.2
1.2
9.90
8.88
mg/l
0.63
140
44
2270
12627
3.15
238.10
16.0
8.6
0.00
0.00
e9/l
0.75
2045
10314
600
1572
4.38
208.44
1.5
1.2
—
—
—
0
0
970
3835
3.09
178.08
1.5
1.6
—
—
—
0
0
169
0
+∞
177.58
2.5
0.0
23.57
—
mg/l
—
161
0
118
42
29.01
176.32
1.8
1.3
88.28
177.40
au/ml
—
18
5
1678
9666
2.38
136.92
4.3
3.1
28.67
34.45
u/l
2.85
1515
9221
1100
5277
2.56
134.11
1.6
1.7
—
—
—
0
0
324
780
4.46
123.36
1.5
1.2
67.94
97.58
titre
1.55
34
66
1990
12804
2.24
119.10
3.8
2.7
102.08
117.42
ug/l
1.44
1890
11999
3491
29601
6.49
112.35
24.8
12.0
15.11
22.94
mg/l
65.30
3097
22981
2061
14018
2.10
99.90
6.9
6.0
10.39
11.26
umol/l
4.19
1994
13326
1402
8417
2.09
93.47
4.0
2.5
58.48
58.15
u/l
0.07
1330
7823
571
2352
2.70
91.54
4.5
3.5
—
—
—
0
0
732
3397
2.45
91.49
2.8
2.5
22.44
24.07
%
2.55
647
2937
444
1646
2.94
86.67
1.8
1.8
1.22
1.33
g/l
0.77
416
1519
807
3997
2.31
86.47
2.8
2.4
13.45
13.97
umol/l
1.18
771
3745
754
3675
2.33
83.59
2.8
2.4
2.42
2.35
g/l
2.69
720
3421
516
2130
2.66
81.82
2.4
2.7
11.36
10.57
g/l
4.18
478
1950
1685
11402
1.90
74.68
2.4
2.0
—
—
—
0
0
1113
6630
1.98
71.73
1.7
1.9
—
—
—
0
0
771
4017
2.17
71.48
1.6
1.3
542.29
512.75
titre
0.18
201
795
1705
11755
1.85
69.64
13.4
12.6
1.15
1.21
inr
2.81
668
3513
286
938
3.23
68.58
1.8
1.8
—
—
—
0
0
1155
7076
1.93
67.80
9.8
6.7
—
—
—
0
0
924
5356
1.97
63.12
2.6
1.6
8212982.57
35818684.34
pmol/l
1.71
828
4534
50
29
17.47
61.00
2.3
1.9
2.16
1.19
mg/l
3.18
44
24
2453
19366
1.83
60.12
4.7
3.9
—
—
—
0
0
3045
25927
2.12
57.92
24.9
14.5
14.42
14.76
%
1.10
3027
25453
162
407
4.12
57.76
1.1
1.2
—
—
—
0
0
1149
7343
1.83
57.10
4.3
3.6
0.00
0.00
estimate
0.07
599
2482
3495
31811
4.12
55.87
21.8
9.1
26.49
27.84
u/l
4.74
3463
30851
501
2409
2.25
55.54
2.7
2.2
0.23
0.22
g/l
4.06
468
2255
755
4279
1.97
53.97
2.2
1.7
1171.68
1166.89
nmol/l
0.04
488
3299
1868
13958
1.70
52.04
3.9
3.3
0.01
0.00
estimate
0.30
603
2468
193
591
3.39
51.53
1.2
1.2
238.69
262.30
u/ml
0.54
120
370
1853
13844
1.70
51.41
3.9
3.3
0.00
0.00
estimate
1.60
621
2677
1843
13817
1.68
49.89
5.0
4.4
0.00
0.00
estimate
0.50
615
2578
1153
7782
1.71
45.18
3.7
2.9
—
—
—
0
0
1029
6758
1.73
44.39
4.6
4.3
—
—
—
0
0
1697
12734
1.63
43.56
7.0
6.6
1.21
1.21
mmol/l
1.35
1407
10899
152
453
3.46
42.31
1.9
1.5
0.75
0.82
g/l
0.21
114
339
212
781
2.82
41.12
1.4
1.1
—
—
—
0
0
1094
7438
1.68
40.86
4.2
4.0
7.40
7.40
ph
0.49
257
1434
902
5827
1.73
40.71
1.6
1.4
2.62
2.36
g/l
2.86
632
3741
1542
11513
1.59
38.94
6.2
5.9
1.21
1.21
mmol/l
1.43
1429
10576
393
1987
2.10
37.65
3.1
2.8
4.13
5.22
e9/l
1.92
297
1694
190
692
2.84
37.62
1.1
1.2
—
—
—
0
0
258
1115
2.42
36.10
1.7
1.5
8.85
23.18
u/ml
0.94
24
24
3277
29791
2.09
35.96
18.1
13.5
139.53
139.68
mmol/l
3.29
3201
29050
244
1032
2.46
35.79
1.2
1.2
—
—
—
0
0
89
204
4.45
35.78
1.5
1.2
284.17
157.14
titre
0.86
36
35
3283
29908
2.08
35.14
18.2
13.6
3.92
3.96
mmol/l
18.78
3205
29105
68
126
5.48
35.04
13.5
26.3
135.16
117.62
ug/l
1.17
61
105
463
2548
1.94
34.84
1.4
1.5
—
—
—
0
0
1480
11248
1.54
32.77
3.3
3.0
5.79
5.87
ph
0.48
103
1074
121
373
3.32
31.95
3.6
3.5
0.99
1.51
%
0.91
114
348
176
684
2.65
30.74
1.9
1.3
5.83
9.45
iu/ml
—
7
13
3373
31333
2.17
29.61
18.7
11.3
—
—
—
0
0
453
2635
1.82
28.37
2.3
2.1
327.95
372.28
nmol/l
5.59
420
2428
584
3703
1.69
26.94
1.3
1.2
—
—
—
0
0
1954
16133
1.46
26.65
5.2
4.6
6.66
6.64
mmol/l
0.17
1832
15003
1336
10334
1.46
25.17
2.0
1.9
95.80
96.74
pmol/l
0.30
778
5517
3523
33616
3.01
24.58
33.7
17.8
40.84
40.93
%
0.24
3365
31832
503
3137
1.70
24.52
3.5
2.7
6.21
7.61
umol/l
1.59
441
2723
3523
33641
2.98
24.06
33.8
17.7
269.78
252.74
e9/l
38.35
3496
32900
31
37
8.44
24.00
1.9
2.1
—
—
—
0
0
3524
33669
2.98
23.78
33.6
17.7
91.62
90.55
fl
36.50
3510
33274
3524
33670
2.98
23.76
33.5
17.6
30.46
30.26
pg
8.73
3510
33272
3524
33675
2.97
23.65
33.7
17.7
4.51
4.57
e12/l
13.37
3491
32858
3524
33676
2.97
23.63
33.8
17.7
6.75
6.69
e9/l
0.90
3490
32854
3524
33685
2.96
23.45
33.9
17.8
136.37
137.63
g/l
6.60
3509
33284
51
107
4.82
22.91
1.6
1.7
—
—
—
0
0
908
6616
1.50
22.62
1.3
1.3
1.18
1.71
u/ml
1.29
254
1852
423
2569
1.73
22.61
3.1
2.4
37.06
56.24
u/l
0.52
364
2216
59
143
4.18
22.16
1.1
1.1
1430.80
1489.62
miu/ml
0.14
59
143
70
194
3.66
21.83
1.5
1.5
—
—
—
0
0
165
778
2.17
18.77
3.0
2.9
—
—
—
0
0
122
511
2.44
18.31
1.3
1.2
80.00
334.55
titre
—
5
11
2089
18096
1.37
18.07
4.4
3.9
270.87
1498.95
e6/l
1.71
24
232
928
7048
1.43
17.94
4.9
3.8
93.86
92.14
%
1.42
896
6884
139
634
2.24
17.18
1.4
1.5
—
—
—
0
0
166
816
2.08
16.98
5.1
3.5
32.00
5039.56
u/ml
0.86
145
701
329
2034
1.68
16.31
4.0
3.6
1.23
1.23
mmol/l
0.06
299
1770
100
405
2.51
16.16
1.1
1.1
1.51
1.47
g/l
0.28
91
363
740
5502
1.43
15.80
2.8
2.5
6.31
5.91
e6/l
0.21
685
4931
68
230
2.99
15.52
3.9
3.7
55.22
55.80
%
0.08
62
207
127
583
2.22
15.48
1.4
1.5
102.56
118.30
u/ml
0.94
30
120
212
1191
1.83
14.69
1.1
1.1
—
—
—
0
0
746
5629
1.41
14.52
1.5
1.5
20.95
20.20
nmol/l
0.65
657
4928
1010
8012
1.36
14.51
3.3
3.1
66.51
112.58
e6/l
0.69
823
6107
929
7305
1.37
14.03
3.2
3.0
0.44
0.40
e6/l
0.22
753
5498
1168
9517
1.34
13.94
3.7
3.5
84.30
90.16
e6/l
0.05
888
6602
17
6
28.45
12.95
1.1
1.0
45.08
—
u/ml
—
5
0
911
7235
1.35
12.69
3.1
2.9
—
—
—
0
0
529
3852
1.44
12.40
2.2
2.0
—
—
—
0
0
683
5205
1.39
12.32
3.1
2.8
565.53
552.42
mosm/kgh2o
0.66
616
4470
572
4234
1.42
12.23
3.6
3.5
0.81
0.82
mmol/l
1.24
536
4008
385
2642
1.51
12.19
3.5
2.7
1.82
1.78
%
0.31
342
2360
1192
9904
1.30
11.94
3.5
3.2
48.82
48.11
ng/l
0.02
753
6096
73
296
2.50
11.86
1.3
1.3
—
—
—
0
0
295
1921
1.58
11.83
3.1
2.8
74.60
71.63
e9/l
0.62
235
1446
194
1137
1.75
11.69
1.3
1.2
0.20
0.79
u/ml
1.60
11
107
348
2360
1.53
11.64
4.1
4.2
5.54
20.56
ug/l
2.48
267
1893
459
3311
1.44
11.27
6.5
6.4
1.01
1.04
mmol/l
1.26
431
3097
71
294
2.44
11.06
1.3
1.3
0.33
0.38
g/l
0.70
41
204
71
295
2.44
10.98
1.3
1.3
2.77
3.03
g/l
0.52
42
207
71
295
2.44
10.98
1.3
1.3
7.84
6.78
g/l
1.11
42
206
809
6433
1.33
10.94
1.8
1.7
1.19
1.04
mg/l
0.88
619
4778
224
1399
1.64
10.67
1.1
1.1
36.00
161.74
titre
—
5
35
620
4765
1.36
10.46
1.3
1.3
4.89
10.67
u/ml
3.19
228
1981
109
553
2.00
10.35
3.6
3.7
—
—
—
0
0
106
533
2.02
10.32
2.3
2.5
16.87
16.57
%
0.27
55
272
648
5035
1.35
10.16
1.3
1.3
15.20
28.84
iu/ml
6.99
189
1597
2307
21103
1.26
9.61
3.9
3.0
50.26
45.62
u/l
1.58
2174
19996
94
468
2.04
9.43
4.0
3.5
63.60
983.63
u/ml
1.03
83
439
123
679
1.84
9.12
3.9
4.1
7.42
7.42
ph
0.67
111
603
107
567
1.91
9.01
3.8
4.2
2.48
2.43
mmol/l
0.07
67
364
883
7293
1.28
8.73
3.0
2.7
—
—
—
0
0
12
6
20.06
8.46
1.2
1.0
—
—
—
0
0
145
865
1.70
8.28
1.5
1.7
0.22
0.23
g/l
1.49
137
821
1026
8674
1.26
8.28
3.6
3.3
2.35
2.35
mmol/l
0.29
928
7763
150
904
1.69
8.26
1.5
1.7
1.17
1.17
g/l
0.05
142
857
29
89
3.28
7.92
1.1
1.3
—
—
—
0
0
881
7349
1.26
7.92
3.4
3.4
—
—
—
0
0
119
682
1.77
7.85
1.6
1.4
303.37
297.46
ug/g
0.11
71
378
85
441
1.95
7.67
1.5
1.4
—
—
—
0
0
48
200
2.42
7.49
1.1
1.1
—
—
—
0
0
316
2295
1.41
7.43
1.4
1.4
—
—
—
0
0
2421
22539
1.23
7.35
3.6
3.8
14.78
14.60
pmol/l
3.07
2232
20765
79
409
1.95
7.20
2.0
2.2
6.52
5.75
umol/l
0.27
50
300
56
255
2.21
7.16
4.4
4.4
—
—
—
0
0
1497
13323
1.21
7.14
2.9
2.5
—
—
—
0
0
459
3576
1.32
6.93
1.2
1.2
—
—
—
0
0
430
3324
1.33
6.85
1.7
1.7
—
—
—
0
0
49
215
2.30
6.85
1.1
1.1
—
—
—
0
0
126
764
1.67
6.84
3.4
3.4
1.36
1.48
mg/l
0.92
113
715
771
6435
1.25
6.76
3.0
2.9
1167.16
1202.91
ng/l
0.09
653
5394
756
6314
1.25
6.58
3.6
3.3
—
—
—
0
0
79
445
1.79
5.63
2.6
2.8
—
—
—
0
0
301
2274
1.35
5.60
8.9
8.2
8.78
9.13
mmol/l
0.42
282
2191
323
2469
1.34
5.56
4.6
4.1
—
—
—
0
0
914
7911
1.21
5.52
2.3
2.1
252.74
230.91
u/l
0.10
861
7483
122
783
1.58
5.35
1.8
2.1
10.46
10.69
mg/l
0.10
113
730
2823
26980
1.21
5.30
4.3
4.4
1.70
2.01
mu/l
3.03
2638
25082
16
34
4.72
5.29
1.5
1.5
—
—
—
0
0
51
256
2.01
5.17
1.1
1.1
277.07
285.84
mg/l
0.36
44
231
285
2164
1.34
5.15
3.6
3.2
—
—
—
0
0
88
526
1.69
5.13
1.1
1.1
—
—
—
0
0
997
8790
1.19
4.82
2.6
2.3
—
—
—
0
0
30
125
2.41
4.79
1.7
1.5
2.83
4.23
%
—
6
30
12
21
5.73
4.75
1.1
1.0
—
—
—
0
0
154
1068
1.46
4.74
1.8
1.8
1.53
1.52
g/l
0.06
139
943
295
2280
1.32
4.73
4.5
3.8
2.11
1.99
mmol/l
0.21
251
1914
216
1592
1.38
4.73
3.4
3.6
5.06
5.16
kpa
1.53
211
1523
420
3403
1.27
4.69
1.6
1.4
—
—
—
0
0
213
1575
1.37
4.58
3.4
3.6
7.41
7.41
ph
0.25
39
199
62
347
1.80
4.58
1.3
1.3
26.36
38.07
u/ml
—
8
19
213
1581
1.37
4.48
6.7
7.1
24.54
24.52
mmol/l
0.04
205
1500
161
1143
1.43
4.40
1.2
1.2
—
—
—
0
0
168
1209
1.41
4.27
3.7
3.1
—
—
—
0
0
50
270
1.86
4.17
1.9
2.8
1.43
1.20
e9/l
0.76
43
249
696
6023
1.19
4.09
3.9
3.6
1.02
1.02
kg/l
0.39
88
831
528
4452
1.22
4.09
2.7
2.6
0.81
1.04
e6/l
1.02
315
2480
137
959
1.45
4.07
2.0
2.1
11.13
1.92
ug/l
0.46
129
860
18
63
2.87
4.06
1.1
1.1
—
—
—
0
0
216
1636
1.34
4.02
4.9
4.9
—
—
—
0
0
207
1572
1.34
3.80
2.4
2.4
—
—
—
0
0
118
817
1.46
3.74
1.3
1.2
46.07
43.36
u/ml
—
7
49
118
819
1.46
3.69
5.6
5.8
1.23
1.30
mmol/l
0.58
108
708
287
2290
1.28
3.67
4.7
3.8
5.86
5.87
kpa
0.10
275
2216
25
110
2.28
3.61
4.2
5.1
—
—
—
0
0
53
307
1.74
3.57
3.3
2.2
—
—
—
0
0
100
678
1.49
3.54
2.3
2.2
—
—
—
0
0
53
310
1.72
3.46
1.9
1.7
42.88
57.43
%
1.56
33
196
73
465
1.58
3.43
2.0
1.7
—
—
—
0
0
87
1282
0.67
3.39
1.4
2.4
—
—
—
0
0
245
1937
1.28
3.39
2.4
2.6
67.88
66.89
g/l
1.24
228
1798
97
663
1.48
3.32
3.4
3.6
1.56
2.49
ratio
0.49
15
59
244
1935
1.28
3.30
1.3
1.3
177.07
199.96
u/ml
0.25
231
1793
27
128
2.12
3.29
1.2
1.1
—
—
—
0
0
36
190
1.90
3.28
2.1
3.1
0.19
0.22
e9/l
0.45
29
172
108
757
1.44
3.25
1.3
1.2
11.89
6.61
u/ml
0.64
21
120
37
198
1.88
3.24
2.2
3.0
554.60
535.97
e6/l
0.07
30
173
576
5008
1.18
3.18
3.1
3.4
638.45
493.34
ng/l
0.23
390
3568
78
515
1.53
3.16
3.8
3.8
—
—
—
0
0
106
745
1.44
3.16
1.3
1.2
9.22
7.06
u/ml
0.14
17
77
295
2408
1.25
3.14
8.8
8.5
122.34
123.93
g/l
0.66
289
2343
313
2577
1.23
3.08
8.5
8.1
96.80
95.78
%
3.83
301
2488
90
617
1.47
3.06
1.3
1.2
29.51
41.06
u/ml
—
9
60
134
987
1.37
3.06
5.6
5.1
0.99
0.90
%
1.65
127
920
97
680
1.44
2.95
3.6
3.6
47.27
64.81
mg/l
0.76
73
550
290
2382
1.24
2.93
1.1
1.2
—
—
—
0
0
71
468
1.53
2.93
1.5
1.6
—
—
—
0
0
83
567
1.47
2.89
2.4
2.3
131.32
131.85
g/l
0.07
72
420
7
13
5.39
2.87
1.0
1.0
—
—
—
0
0
58
367
1.59
2.86
3.7
2.6
—
—
—
0
0
432
3699
1.19
2.86
1.5
1.4
—
—
—
0
0
215
1718
1.27
2.78
2.9
2.5
—
—
—
0
0
12
39
3.08
2.77
1.7
1.8
—
—
—
0
0
96
682
1.42
2.74
3.6
3.6
41.47
64.36
mg/l
0.54
73
553
182
2300
0.78
2.73
1.4
1.4
—
—
—
0
0
148
1130
1.32
2.71
4.8
3.4
25.06
25.35
mmol/l
0.45
142
1094
481
4178
1.17
2.70
2.9
2.8
2.61
2.44
e6/l
0.14
267
2220
78
535
1.47
2.69
1.1
1.1
—
—
—
0
0
10
266
0.37
2.66
15.1
18.0
1283.90
1420.20
nmol/l
—
10
259
132
994
1.34
2.66
5.6
5.1
1.59
1.69
%
0.78
126
924
24
119
2.02
2.65
1.1
1.1
—
—
—
0
0
27
140
1.94
2.64
1.2
1.1
149.05
186.82
iu/ml
0.49
27
140
134
1013
1.34
2.64
5.0
4.8
—
—
—
0
0
37
213
1.74
2.63
1.3
1.1
—
—
—
0
0
114
1525
0.74
2.61
1.3
2.4
—
—
—
0
0
41
245
1.68
2.56
1.7
1.5
37.67
33.23
%
0.26
21
159
21
101
2.09
2.52
3.3
2.9
—
—
—
0
0
18
82
2.20
2.47
1.1
1.0
—
—
—
0
0
158
1235
1.29
2.47
1.8
1.8
—
—
—
0
0
816
7413
1.13
2.43
2.6
2.5
3268.68
3658.15
umol/l
0.12
728
6638
742
6707
1.13
2.40
2.6
2.2
—
—
—
0
0
83
591
1.41
2.38
1.1
1.1
—
—
—
0
0
254
2108
1.22
2.38
9.8
8.9
—
—
—
0
0
217
1772
1.24
2.37
4.0
4.1
91.32
88.59
ng/l
0.13
194
1580
83
593
1.41
2.35
1.1
1.1
—
—
—
0
0
339
2896
1.19
2.34
8.1
7.6
1.04
1.04
mmol/l
0.00
270
2290
207
1685
1.24
2.33
1.4
1.4
27.80
26.08
iu/l
0.31
175
1432
21
105
2.01
2.30
1.0
1.1
—
—
—
0
0
460
4038
1.16
2.27
2.6
2.2
29.92
29.77
s
0.21
443
3920
30
171
1.76
2.24
1.2
1.4
1.34
1.26
nmol/l
0.16
25
135
110
831
1.33
2.22
1.1
1.1
—
—
—
0
0
2075
19888
1.10
2.20
3.6
3.4
—
—
—
0
0
67
468
1.44
2.17
3.8
3.2
—
—
—
0
0
56
813
0.68
2.14
1.6
1.5
—
—
—
0
0
337
2902
1.18
2.14
8.2
7.7
5.05
5.12
kpa
0.67
321
2779
247
2069
1.21
2.13
2.8
2.2
5.05
7.89
ug/l
3.01
222
1860
337
2903
1.18
2.13
8.1
7.7
12.73
12.66
kpa
0.09
322
2776
16
75
2.14
2.08
1.0
1.2
—
—
—
0
0
33
199
1.66
2.05
1.1
1.1
1.03
1.05
ratio
0.74
17
76
55
792
0.69
2.03
1.5
1.4
—
—
—
0
0
17
83
2.05
2.01
3.1
3.2
—
—
—
0
0
55
789
0.69
1.99
1.5
1.4
—
—
—
0
0
223
1868
1.21
1.95
4.3
3.1
4.32
4.68
kpa
2.10
214
1800
66
471
1.41
1.93
1.2
1.2
—
—
—
0
0
31
188
1.65
1.90
1.0
1.1
—
—
—
0
0
83
1103
0.75
1.90
1.5
3.3
—
—
—
0
0
132
1650
0.79
1.89
1.3
2.3
—
—
—
0
0
105
811
1.30
1.87
2.0
2.4
11.62
10.32
g/l
1.25
92
745
131
1636
0.79
1.87
1.3
2.3
—
—
—
0
0
351
3999
0.86
1.85
1.3
1.3
—
—
—
0
0
132
1644
0.80
1.84
1.3
2.2
—
—
—
0
0
6
17
3.53
1.83
1.0
1.1
—
—
—
0
0
50
713
0.70
1.78
1.4
3.1
—
—
—
0
0
90
687
1.32
1.76
1.8
2.2
38.86
38.05
g/l
0.66
78
623
2712
26462
1.10
1.72
26.3
15.2
332.33
333.38
g/l
7.74
2703
26268
76
568
1.35
1.72
4.7
3.9
—
—
—
0
0
305
2657
1.16
1.72
2.2
2.3
12.70
13.16
nmol/l
0.44
277
2406
38
250
1.53
1.70
4.3
3.1
—
—
—
0
0
42
283
1.49
1.69
1.1
1.4
—
—
—
0
0
21
119
1.77
1.66
1.0
1.1
—
—
—
0
0
49
343
1.43
1.64
1.3
1.3
—
—
—
0
0
87
669
1.31
1.63
1.6
1.3
—
—
—
0
0
39
261
1.50
1.63
2.7
2.5
—
—
—
0
0
132
1616
0.81
1.61
1.3
2.3
—
—
—
0
0
48
337
1.43
1.59
1.6
1.4
53.72
52.53
mu/l
0.02
39
305
496
4493
1.12
1.57
3.0
2.9
2.45
2.44
mmol/l
0.83
434
3945
166
1386
1.21
1.55
2.3
2.3
7617.14
5368.45
u/l
0.36
57
548
183
2162
0.84
1.55
1.2
1.2
97.15
160.60
iu/ml
1.83
67
820
10
44
2.28
1.55
2.2
3.2
—
23.65
—
0
8
34
224
1.52
1.54
1.1
1.2
—
77.92
—
0
10
8
33
2.43
1.53
3.4
1.9
123.00
138.64
ng/l
—
8
33
0
45
0.00
1.49
0.0
1.5
—
—
—
0
0
162
1357
1.20
1.48
12.3
10.5
—
—
—
0
0
81
627
1.30
1.48
1.7
1.7
8653.56
13012.33
e6/l
0.97
61
457
25
155
1.62
1.46
2.0
2.8
1288.40
1026.90
u/ml
0.32
25
155
178
1508
1.19
1.44
4.8
3.1
130.33
131.16
g/l
0.18
171
1468
54
395
1.37
1.44
2.6
2.4
—
—
—
0
0
11
52
2.12
1.44
1.0
1.2
—
—
—
0
0
11
52
2.12
1.44
1.0
1.2
—
—
—
0
0
11
52
2.12
1.44
1.0
1.2
—
—
—
0
0
44
311
1.42
1.43
1.1
1.1
—
—
—
0
0
47
337
1.40
1.41
2.4
1.5
—
—
—
0
0
34
229
1.49
1.41
2.2
2.9
709.91
694.30
e6/l
0.05
34
223
15
81
1.86
1.40
1.2
1.3
114.12
149.73
nmol/l
—
10
60
27
173
1.56
1.40
3.4
6.9
—
—
—
0
0
5
17
2.94
1.36
1.0
1.1
—
—
—
0
0
22
135
1.63
1.35
1.9
1.6
—
—
—
0
0
17
97
1.76
1.34
2.9
2.5
—
—
—
0
0
257
2261
1.15
1.32
8.6
7.3
1.27
1.37
mmol/l
1.03
249
2204
19
114
1.67
1.28
1.1
1.1
—
—
—
0
0
20
123
1.63
1.24
1.5
1.3
—
—
—
0
0
104
853
1.23
1.22
1.0
1.1
0.88
4.08
u/ml
—
10
126
50
375
1.34
1.18
1.2
1.2
—
—
—
0
0
54
410
1.32
1.18
1.3
1.7
—
—
—
0
0
132
1113
1.19
1.18
2.5
2.1
21.25
21.42
s
0.13
111
961
96
1168
0.82
1.17
1.6
1.4
—
—
—
0
0
10
186
0.54
1.17
1.1
3.1
—
—
—
0
0
0
33
0.00
1.16
0.0
1.2
—
1.81
—
0
33
0
34
0.00
1.16
0.0
8.3
—
—
—
0
0
0
35
0.00
1.15
0.0
1.0
—
—
—
0
0
44
326
1.35
1.14
1.1
1.3
—
—
nmol/l
—
0
0
110
917
1.21
1.12
2.8
2.5
—
—
—
0
0
50
379
1.32
1.12
1.5
1.4
57.73
65.32
mmol/l
0.66
33
311
95
782
1.22
1.10
1.1
1.1
—
—
—
0
0
42
311
1.35
1.10
3.5
2.6
—
—
—
0
0
135
1150
1.18
1.09
1.2
1.3
236.99
229.51
miu/ml
0.08
59
552
32
227
1.41
1.07
1.2
1.2
—
—
—
0
0
75
604
1.25
1.07
1.5
2.3
0.92
0.86
nmol/l
0.32
66
513
7
33
2.12
1.05
1.3
1.3
29.14
853.50
u/l
—
7
26
8
147
0.54
1.03
2.0
2.5
51.63
52.26
umol/l
—
8
128
18
114
1.58
1.02
1.0
1.0
—
—
—
0
0
18
114
1.58
1.02
1.3
1.2
—
—
—
0
0
30
415
0.72
1.01
4.5
3.7
18.50
26.71
u/ml
0.84
30
405
14
226
0.62
1.00
1.6
1.6
—
—
—
0
0
34
249
1.37
0.97
1.3
1.2
—
—
—
0
0
7
36
1.95
0.97
1.0
1.1
—
—
—
0
0
45
345
1.31
0.96
1.2
1.3
—
—
—
0
0
215
1918
1.13
0.96
2.5
2.7
178.01
174.13
ng/l
0.05
190
1727
28
199
1.41
0.95
1.0
1.0
—
—
—
0
0
30
217
1.39
0.93
1.6
1.4
94.67
79.18
umol/l
0.50
30
217
76
625
1.22
0.93
1.4
1.5
58.81
125.67
pmol/l
2.27
76
613
347
3186
1.10
0.92
1.4
1.4
—
—
—
0
0
10
55
1.82
0.92
6.1
6.3
—
—
—
0
0
13
208
0.62
0.91
1.5
1.5
—
—
—
0
0
26
184
1.42
0.91
1.1
1.2
—
—
—
0
0
122
1051
1.17
0.90
1.5
1.4
9.42
8.93
u/l
0.18
96
856
85
710
1.20
0.89
1.2
1.3
—
—
—
0
0
177
1993
0.88
0.89
1.5
1.6
—
—
—
0
0
24
170
1.41
0.85
5.3
3.4
—
—
—
0
0
17
112
1.52
0.84
1.1
1.1
—
—
—
0
0
8
45
1.78
0.84
7.4
6.8
—
—
—
0
0
131
1143
1.15
0.84
3.5
3.6
—
—
—
0
0
30
223
1.35
0.81
1.1
1.2
—
—
—
0
0
828
7905
1.06
0.80
4.3
3.9
10.17
9.51
mg/mmol
0.11
554
5150
211
1908
1.11
0.78
1.4
1.4
—
—
—
0
0
970
9314
1.06
0.77
4.5
4.3
2.12
2.35
ug/l
0.64
883
8418
20
140
1.43
0.76
2.4
2.3
25.66
246.22
ug/l
0.66
20
124
30
226
1.33
0.76
2.5
2.2
—
—
—
0
0
59
486
1.22
0.75
1.2
1.2
3.43
4.51
u/ml
0.51
30
217
58
477
1.22
0.75
2.2
1.9
5.97
5.31
mmol/24h
0.63
52
425
35
271
1.29
0.74
1.0
1.1
242.07
281.77
mg/l
1.15
29
233
19
133
1.43
0.73
1.6
2.7
7.40
7.42
ph
0.56
11
49
29
219
1.33
0.73
1.1
1.1
341.12
394.45
nmol/l
0.78
23
199
787
7532
1.06
0.71
3.6
3.3
211.31
365.46
mg/l
0.68
531
4934
7
40
1.75
0.71
1.3
1.2
1.94
1.58
mmol/l
—
7
27
26
194
1.34
0.71
1.0
1.0
—
—
—
0
0
14
93
1.51
0.69
1.4
1.3
—
—
—
0
0
47
574
0.82
0.68
3.0
3.2
25.10
24.90
mg/l
0.02
30
370
52
429
1.22
0.67
2.2
1.8
—
—
—
0
0
16
225
0.71
0.65
1.4
1.5
—
—
—
0
0
28
215
1.30
0.65
1.9
2.3
930.53
618.03
ml
1.57
19
147
29
224
1.30
0.64
1.5
1.6
—
—
—
0
0
5
29
1.73
0.64
1.6
1.1
—
—
—
0
0
56
470
1.19
0.62
1.3
1.5
—
—
—
0
0
24
182
1.32
0.61
1.1
1.1
12.94
9.90
iu/ml
—
5
57
24
182
1.32
0.61
1.9
2.9
33.88
42.64
%
—
8
93
16
113
1.42
0.61
1.5
2.3
—
—
—
0
0
35
280
1.25
0.60
1.1
1.2
48.08
43.20
mg/l
0.19
29
231
14
97
1.45
0.59
2.2
1.5
1151.36
152.43
nmol/24h
0.42
14
97
48
573
0.84
0.58
1.4
1.3
—
—
—
0
0
24
184
1.31
0.57
1.9
1.4
6.26
7.18
u/l
0.34
16
158
7
116
0.60
0.57
1.0
1.0
—
—
—
0
0
774
7452
1.05
0.57
1.7
1.6
1.40
1.42
mmol/l
0.29
649
6385
17
230
0.74
0.57
1.4
1.5
16740.83
80071.21
e6/l
1.51
12
143
16
115
1.39
0.56
1.1
1.2
—
0.12
g/l
—
0
11
16
115
1.39
0.56
2.4
2.8
—
—
—
0
0
101
897
1.13
0.56
3.8
3.4
0.41
0.34
g/l
0.21
53
391
59
688
0.86
0.55
1.6
1.6
—
—
—
0
0
10
65
1.54
0.55
2.0
2.5
—
—
—
0
0
12
82
1.46
0.54
1.2
1.4
—
—
—
0
0
6
39
1.54
0.53
4.5
2.9
—
—
—
0
0
39
324
1.21
0.50
1.4
1.4
373.39
308.47
pmol/l
0.49
33
281
59
511
1.16
0.49
1.1
1.1
2.65
1090.49
iu/ml
0.57
13
127
34
280
1.22
0.48
3.1
4.9
87.09
73.17
u/ml
—
10
80
2853
28274
1.04
0.48
4.2
4.1
5.88
5.86
mmol/l
0.29
2641
26189
45
527
0.85
0.47
1.3
1.2
—
—
—
0
0
7
48
1.46
0.46
2.1
1.4
—
—
—
0
0
22
173
1.27
0.46
1.0
1.0
310.94
310.07
ng/l
0.01
17
118
16
120
1.33
0.46
1.8
3.1
61.89
133.57
umol/l
—
9
69
8
117
0.68
0.45
8.8
5.8
—
—
—
0
0
8
117
0.68
0.45
4.4
2.9
—
—
—
0
0
47
543
0.86
0.42
1.4
1.2
—
—
—
0
0
18
229
0.78
0.42
1.1
1.3
1.53
1.55
g/l
0.12
18
229
891
8668
1.04
0.42
1.6
1.5
—
—
—
0
0
31
258
1.20
0.41
2.0
2.7
—
—
—
0
0
30
249
1.21
0.41
1.4
1.4
2742.00
87143.38
e6/l
1.42
17
175
30
249
1.21
0.41
1.2
1.3
1.38
1.50
nmol/l
0.34
25
225
0
15
0.00
0.41
0.0
5.9
—
461.47
—
0
15
0
17
0.00
0.40
0.0
1.1
—
0.21
—
0
6
26
315
0.82
0.40
1.6
1.7
—
—
—
0
0
16
123
1.30
0.40
1.1
1.2
—
—
—
0
0
21
170
1.24
0.37
1.0
1.0
798.38
757.88
ng/l
0.25
13
114
183
1946
0.94
0.36
1.3
1.3
47.09
51.68
au/ml
—
10
108
12
90
1.33
0.35
2.3
1.7
—
—
—
0
0
21
171
1.23
0.35
1.2
1.2
—
—
—
0
0
24
199
1.21
0.35
1.2
1.2
—
—
—
0
0
32
274
1.17
0.34
3.7
2.6
1.62
1.64
g/24h
0.02
21
147
526
5426
0.96
0.32
2.7
2.8
0.77
0.72
ug/l
0.41
328
3278
29
248
1.17
0.31
1.0
1.1
—
—
—
0
0
121
1128
1.08
0.31
1.9
1.7
—
—
—
0
0
26
221
1.18
0.30
1.8
1.9
6.87
6.72
mmol/l
0.10
17
156
22
261
0.84
0.30
1.1
1.2
—
—
—
0
0
308
3205
0.96
0.30
4.1
4.1
31.61
31.33
%
0.19
233
2287
11
84
1.31
0.30
1.1
1.5
—
—
—
0
0
7
55
1.27
0.30
1.7
1.2
—
—
—
0
0
27
231
1.17
0.29
1.2
1.1
—
—
—
0
0
14
174
0.80
0.29
1.1
1.3
—
—
—
0
0
2683
26643
1.03
0.29
5.4
5.1
39.08
39.13
mmol/mol
0.10
2535
25041
18
148
1.22
0.29
1.1
1.2
—
—
—
0
0
40
354
1.13
0.29
2.9
3.1
0.82
0.83
nmol/l
0.07
33
273
8
63
1.27
0.27
2.8
2.3
—
—
—
0
0
8
65
1.23
0.27
1.3
1.1
—
—
—
0
0
8
65
1.23
0.27
1.3
1.1
—
—
—
0
0
8
65
1.23
0.27
1.3
1.1
—
—
—
0
0
862
8454
1.03
0.26
3.4
3.3
8.57
8.07
mmol/l
2.23
737
7300
180
1887
0.95
0.25
1.2
1.2
—
—
—
0
0
55
601
0.91
0.24
1.1
1.1
1.74
1.73
u/ml
0.00
27
277
202
2109
0.96
0.24
2.3
2.3
26.34
23.58
au/ml
0.11
17
190
24
274
0.88
0.22
1.9
1.4
1.42
1.38
promille
0.04
18
210
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
100
944
1.06
0.21
8.6
8.8
—
—
—
0
0
94
886
1.06
0.21
2.3
2.5
188.74
447.77
ug/l
2.34
86
832
0
13
0.00
0.21
0.0
1.7
—
1918.54
—
0
13
26
230
1.13
0.20
1.2
1.2
0.24
1.58
u/ml
—
10
124
0
14
0.00
0.20
0.0
1.0
—
0.18
—
0
7
23
202
1.14
0.20
1.0
1.0
10.70
2.00
u/ml
—
9
58
16
136
1.18
0.20
1.7
1.6
—
—
—
0
0
9
112
0.80
0.20
1.2
1.4
69.56
72.60
%
—
9
107
33
298
1.11
0.19
3.1
2.9
24.76
22.15
nmol/l
0.04
33
289
104
988
1.05
0.19
4.2
3.7
24.76
24.84
mmol/l
0.13
96
920
138
1323
1.04
0.18
1.5
1.6
276.02
294.07
mu/l
0.42
125
1198
7
59
1.19
0.18
1.0
1.1
0.20
4.85
u/ml
—
7
52
49
527
0.93
0.17
1.0
1.1
1.23
3.67
u/ml
2.85
20
243
69
650
1.06
0.17
2.3
2.3
166.29
120.79
ug/min
0.27
41
408
8
71
1.13
0.16
1.8
1.3
62.25
31.46
%
—
8
46
16
140
1.14
0.15
1.5
1.6
—
—
—
0
0
67
634
1.06
0.15
1.4
1.5
—
—
—
0
0
9
83
1.08
0.14
1.3
1.1
—
—
—
0
0
72
684
1.05
0.14
1.1
1.3
3.51
3.73
mmol/l
1.26
65
643
59
557
1.06
0.14
1.5
1.5
0.30
0.39
nmol/l
0.67
46
442
67
706
0.95
0.14
1.1
1.1
2.08
2.13
u/ml
0.02
26
344
12
139
0.86
0.14
1.0
1.3
111.97
173.26
mmol/24h
2.30
12
139
2834
28435
0.98
0.14
3.8
3.7
1.31
1.32
mmol/l
0.26
2646
26588
8
98
0.82
0.13
8.5
12.7
—
—
—
0
0
2989
29974
0.98
0.13
4.5
4.4
2.76
2.84
mmol/l
2.91
2796
28135
15
132
1.14
0.13
1.2
1.1
—
—
—
0
0
9
109
0.83
0.13
1.2
1.4
333.00
418.89
mu/l
—
9
104
23
210
1.10
0.12
1.0
1.0
0.64
0.85
u/ml
—
9
45
45
424
1.06
0.12
1.4
1.4
—
—
—
0
0
61
640
0.95
0.11
1.0
1.1
6.33
5.90
u/ml
0.06
25
336
122
1257
0.97
0.11
2.4
2.3
—
—
—
0
0
41
434
0.94
0.10
1.4
1.3
6.97
7.02
mmol/l
0.04
36
388
46
484
0.95
0.10
1.0
1.1
3.65
4.82
u/ml
0.36
17
192
2936
29428
0.99
0.10
4.2
4.0
1.46
1.43
mmol/l
2.12
2757
27667
42
443
0.95
0.10
1.0
1.0
0.67
0.42
u/ml
—
6
119
21
193
1.09
0.10
1.6
2.0
1.36
1.77
u/field
0.40
14
93
5
47
1.06
0.09
1.0
1.2
—
—
—
0
0
13
116
1.12
0.09
1.2
1.5
—
—
—
0
0
28
262
1.07
0.09
1.8
1.5
0.89
0.97
g/l
0.95
28
262
6
56
1.07
0.08
1.2
1.1
—
—
—
0
0
43
451
0.95
0.08
1.1
1.3
2.73
4.07
ug/l
1.20
38
410
71
735
0.97
0.08
2.5
1.9
4.07
4.57
iu/l
0.21
29
276
187
1835
1.02
0.08
3.3
3.3
4.50
4.53
pmol/l
0.18
168
1649
34
322
1.06
0.08
1.4
1.5
—
—
—
0
0
55
572
0.96
0.08
5.8
2.8
—
—
—
0
0
1183
11894
0.99
0.07
2.8
2.6
—
—
—
0
0
6
73
0.82
0.07
2.2
2.3
—
—
—
0
0
50
482
1.04
0.06
1.0
1.1
1.87
2.80
u/ml
0.86
18
250
2963
29590
1.01
0.05
4.3
4.1
4.67
4.72
mmol/l
2.22
2788
27943
12
130
0.92
0.04
2.3
2.3
—
—
—
0
0
70
685
1.02
0.04
1.3
1.5
624.39
1278.59
e6/l
0.45
61
556
70
685
1.02
0.04
1.2
1.5
167.02
29.40
e6/l
0.42
57
530
42
433
0.97
0.04
1.2
1.2
20.25
48.56
u/l
2.19
37
376
12
111
1.08
0.04
2.0
1.7
—
—
—
0
0
13
121
1.07
0.03
2.4
2.6
—
—
—
0
0
369
3667
1.01
0.03
1.7
1.7
—
—
—
0
0
13
122
1.07
0.02
1.9
1.7
—
—
—
0
0
351
3528
0.99
0.02
1.6
1.7
—
—
—
0
0
15
157
0.96
0.01
1.1
1.4
140.97
135.44
nmol/l
0.22
15
157
21
203
1.03
0.01
1.2
1.2
—
—
—
0
0
46
467
0.98
0.01
1.1
1.6
—
—
—
0
0
21
204
1.03
0.00
1.0
1.0
—
—
—
0
0
21
205
1.02
0.00
1.0
1.0
1.01
2.36
u/ml
—
6
43
30
305
0.98
0.00
1.3
1.4
169.24
197.97
pmol/l
0.37
30
305
153
1525
1.00
0.00
1.1
1.1
—
—
—
0
0
12
121
0.99
0.00
1.1
1.1
17.78
12.53
u/ml
—
6
77
26
264
0.98
0.00
1.6
1.6
7.57
7.65
mmol/l
0.06
26
254
20
197
1.02
0.00
1.7
2.3
—
—
—
0
0
7
73
0.96
0.00
2.1
2.1
14.21
16.14
umol/l
—
7
73
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
542.78
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
2923.32
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
186.29
—
0
8
54
540
1.00
-0.00
1.3
1.4
27.39
24.74
u/l
0.22
45
443
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
64.83
—
0
6
5
57
0.88
-0.00
1.2
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
98
0.92
-0.00
2.1
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
1.92
—
0
5
7
78
0.90
-0.00
2.1
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
61
610
1.00
-0.00
1.0
1.1
0.70
1.41
u/ml
0.91
20
247
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint ULCERRECT and mortality.

Females

Parameter HR [95% CI] p-value
ULCERRECT 1.163 [1.04, 1.3] 0.008
Birth year 0.996 [0.99, 1.0] 0.309

During the follow-up period (1.1.1998 — 31.12.2019), 677 out of 8056 females with ULCERRECT died.

Males

Parameter HR [95% CI] p-value
ULCERRECT 1.093 [1.0, 1.2] 0.061
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1254 out of 9221 males with ULCERRECT died.

Mortality risk

Mortality risk for people of age

years, who have ULCERRECT.

N-year risk Females Males
1 0.07% 0.233%
5 0.59% 1.167%
10 1.628% 2.921%
15 3.162% 5.473%
20 5.425% 8.891%

Relationships between endpoints

Index endpoint: ULCERRECT – Ulcerative rectosigmoiditis

GWS hits: 18

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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