Parkinson's disease

G6_PARKINSON

Parkinson's disease: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 G20
Hospital discharge: ICD-9 3320A
Hospital discharge: ICD-8 34200
Cause of death: ICD-10 G20
Cause of death: ICD-9 3320A
Cause of death: ICD-8 34200
KELA reimbursements: KELA codes 110

3075

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3075

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Check minimum number of events None

3075

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Include endpoints None

3075

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G6_PARKINSON

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Morbus Parkinson

Summary Statistics

Key figures

All Female Male
Number of individuals 2989 1221 1768
Unadjusted prevalence (%) 0.97 0.70 1.31
Mean age at first event (years) 66.84 65.93 67.46

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.73 [3.98, 5.62] 4.0e-70 800
15 years 0.02 2.55 [2.15, 3.02] 3.0e-27 400
5 years - - - -
1 year - - - -

Correlations

Index endpoint: G6_PARKINSON – Parkinson's disease
GWS hits: 2

Survival analyses between endpoints

Plot

before Parkinson's disease
after Parkinson's disease

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Drugs most likely to be purchased after Parkinson's disease