No definition available.
Other and unspecified disorders of white blood cells
DOID EFO Endpoint Browser PheWeb
D3_WHITEBLOODCELLNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1489 |
4. Check minimum number of eventsNone |
1489 |
5. Include endpointsNone |
1489 |
6. Filter based on genotype QC (FinnGen only) |
1489 |
Control definitions (FinnGen only)
- Control exclude
- D3_BLOODOTHER
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of white blood cells
based on the number of shared cases.
Similar with more cases:
- Other disorders of white blood cells
- Other diseases of blood and blood-forming organs, wide
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 11640 | 6110 | 5442 |
| Only index persons | 9637 | 5134 | 4503 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.16 | 0.18 | 0.15 |
| Only index persons | 0.18 | 0.19 | 0.17 |
| Median age at first event (years) | |||
| Whole population | 59.46 | 58.68 | 60.22 |
| Only index persons | 57.31 | 56.07 | 58.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1489 | 795 | 694 |
| Unadjusted period prevalence (%) | 0.29 | 0.27 | 0.31 |
| Median age at first event (years) | 56.74 | 52.20 | 61.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1373
- Matched controls
- 13730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
10013.2
323.0
1082
5
XW000
NOMESCO Finland
Bone marrow biopsy
34.1
323.0
432
182
D72.9
ICD-10 Finland
Disorder of white blood cells, unspecified
797.3
273.0
260
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
20.7
194.7
300
183
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
62.8
183.3
213
40
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
78.8
114.7
129
18
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
93.7
373
1013
D70.89
ICD-10 Finland
Neutropenic splenomegaly
295.3
82.5
83
*
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
38.0
77.6
99
28
2888B
ICD-9 Finland
Diseases of white blood cells, Other specified disease of white blood cells[LEUCOPENIA]
+∞
72.5
69
*
C92.1
ICD-10 Finland
Chronic myeloid leukaemia [CML], BCR/ABL-positive
189.7
69.8
72
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
65.9
740
4155
L01XX05
ATC
hydroxycarbamide; oral
28.4
57.1
78
29
M04AA01
ATC
allopurinol; systemic
3.5
53.7
282
932
R50.9
ICD-10 Finland
Fever, unspecified
3.3
49.8
291
1035
189
Kela drug reimbursment
Imatinib
71.4
48.4
55
8
L03AA02
ATC
filgrastim; parenteral
9.8
47.2
98
107
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
44.9
412
1945
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
14.0
44.4
77
58
L01XE01
ATC
[U] imatinib; oral
63.4
42.5
49
8
WW500
NOMESCO Finland
Blood transfusion
6.4
42.1
116
196
C92.0
ICD-10 Finland
Acute myeloblastic leukaemia [AML]
51.8
41.9
50
10
D70.82
ICD-10 Finland
Drug-induced neutropenia
+∞
40.8
39
*
R72
ICD-10 Finland
Abnormality of white blood cells, not elsewhere classified
66.4
39.3
45
7
9863/3-C42.1
ICD-O-3
Chronic myeloid leukemia, NOS, of bone marrow
366.5
36.1
36
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
36.1
215
761
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.1
33.3
137
360
JN4BD
NOMESCO Finland
Extensive body CT
2.9
30.7
211
819
C91.7
ICD-10 Finland
Other lymphoid leukaemia
+∞
30.3
29
*
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
59.8
30.2
35
6
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
44.8
28.8
35
8
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.1
28.7
173
614
J01MA12
ATC
levofloxacin; systemic
2.3
28.5
306
1514
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
49.7
28.5
34
7
H02AB06
ATC
prednisolone; systemic
1.9
28.3
658
4473
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
26.2
325
1713
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
25.6
176
680
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
13.3
25.3
44
34
L01EA01
ATC
imatinib; oral (bcr-abl tyrosine kinase inhibitors)
71.2
24.9
28
*
ZX120
NOMESCO Finland
Intravenous
2.8
24.8
172
668
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
24.1
418
2514
A02BC02
ATC
pantoprazole; systemic
1.8
23.9
881
6830
A04AA01
ATC
ondansetron; systemic, rectal
3.3
23.5
127
416
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
34.0
23.4
30
9
B73
ICPC
Leukaemia
122.0
22.6
24
*
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
122.0
22.6
24
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
22.6
169
685
127
Kela drug reimbursment
Transplant complication
8.3
22.0
49
61
152
Kela drug reimbursment
Nilotinib
+∞
21.9
21
*
ZXE00
NOMESCO Finland
One hour or less
1.8
21.6
563
3857
316
Kela drug reimbursment
Imatinib
50.8
21.2
25
5
D47.1
ICD-10 Finland
Chronic myeloproliferative disease
37.8
20.8
26
7
C03CA01
ATC
furosemide; systemic
1.9
20.8
400
2470
L01BB05
ATC
fludarabine; systemic
78.0
20.7
23
*
WW200
NOMESCO Finland
Immunization
5.1
20.4
65
132
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
20.2
442
2848
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.5
20.0
96
287
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.2
20.0
112
375
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
7.8
20.0
46
61
Z2221
NOMESCO Finland
Medical doctor
1.8
19.8
404
2539
9861/3-C42.1
ICD-O-3
Acute myeloid leukemia, NOS, of bone marrow
74.6
19.7
22
*
J01DB01
ATC
cefalexin; oral
1.9
19.7
1098
9376
Z3231
NOMESCO Finland
Registered nurse
1.8
19.7
396
2479
H02AB09
ATC
hydrocortisone; systemic
5.3
19.5
60
117
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
19.1
230
1180
A03FA01
ATC
metoclopramide; systemic, rectal
2.0
19.1
289
1628
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
24.1
18.7
26
11
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.7
18.6
679
5067
1512
Kela drug reimbursment
Ibrutinib
67.5
17.7
20
*
390
Kela drug reimbursment
Ibrutinib
67.5
17.7
20
*
J01MA14
ATC
moxifloxacin; systemic
2.5
17.0
141
600
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.7
16.8
124
495
D72.1
ICD-10 Finland
Eosinophilia
+∞
16.7
16
*
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
16.7
375
2410
JN4AD
NOMESCO Finland
Body CT examination
2.6
16.5
123
494
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
16.4
493
3446
J05AB11
ATC
valaciclovir; oral
2.2
16.0
183
915
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.5
15.7
130
554
2888A
ICD-9 Finland
Diseases of white blood cells, Other specified disease of white blood cells[LEUCOCYTOSIS]
+∞
15.6
15
*
L01XX28
ATC
[D] imatinib; oral
+∞
15.6
15
*
150
Kela drug reimbursment
Dasatinib
86.1
15.6
17
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
15.6
252
1444
TNE20
NOMESCO Finland
Bone marrow aspiration, pelvis
38.5
15.4
19
5
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
15.2
83
275
L04AD01
ATC
ciclosporin; systemic
5.3
15.1
46
90
D75.2
ICD-10 Finland
Essential thrombocytosis
57.3
14.8
17
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.1
14.7
57
143
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
14.7
289
1769
9835/3-C42.1
ICD-O-3
Precursor cell lymphoblastic leukemia, NOS, of bone marrow
151.5
14.5
15
*
399
Kela drug reimbursment
Venetoclax
151.5
14.5
15
*
T86.0
ICD-10 Finland
Bone-marrow transplant rejection
36.4
14.5
18
5
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.4
14.3
123
536
B99
ICD-10 Finland
Other and unspecified infectious diseases
5.0
14.2
45
92
212
Kela drug reimbursment
Gout
4.7
13.8
46
100
R03BB04
ATC
tiotropium bromide; inhalant
2.2
13.7
145
697
L01XE06
ATC
[U] dasatinib; systemic
75.9
13.6
15
*
A41.9
ICD-10 Finland
Sepsis, unspecified
3.4
13.6
67
207
L01XE27
ATC
[U] ibrutinib; oral
141.3
13.5
14
*
L01XX52
ATC
venetoclax; oral
141.3
13.5
14
*
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
13.3
523
3866
TGC00
NOMESCO Finland
Bronchial lavation
4.1
13.0
50
125
R4110
NOMESCO Finland
Physiotherapy
1.7
13.0
353
2371
A05AA02
ATC
ursodeoxycholic acid; oral
5.3
12.9
39
76
L01AA02
ATC
chlorambucil; oral
19.2
12.9
19
10
UJF30
NOMESCO Finland
Ileoscopy through colon
2.2
12.8
140
684
D45
ICD-10 Finland
Polycythaemia vera
8.1
12.8
28
35
WX892
NOMESCO Finland
Monitored bed care
2.4
12.8
110
480
N06AX16
ATC
venlafaxine; oral
2.0
12.7
174
931
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
15.6
12.6
20
13
9961/3-C42.1
ICD-O-3
Primary myelofibrosis of bone marrow
70.5
12.6
14
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.7
12.6
89
348
L01XE08
ATC
[U] nilotinib; oral
+∞
12.5
12
*
N02BE01
ATC
paracetamol; systemic, rectal
1.7
12.5
1122
10009
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
12.5
227
1346
Z2446
NOMESCO Finland
Social worker
2.5
12.4
102
435
Z3226
NOMESCO Finland
Physiotherapist
1.8
12.4
255
1575
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
12.3
122
572
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
2.7
12.2
81
306
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
4.4
12.1
43
100
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
12.1
224
1336
L03AA13
ATC
pegfilgrastim; parenteral
3.4
12.0
57
171
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
12.0
284
1826
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
11.9
172
942
WX110
NOMESCO Finland
Local anesthesy
1.5
11.9
864
7269
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
11.8
215
1276
A07AA02
ATC
nystatin; oral
2.5
11.8
91
374
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.2
11.8
62
202
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
11.7
204
1190
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
6.1
11.7
31
52
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
65.5
11.6
13
*
D47.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue, unspecified
19.1
11.6
17
9
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
11.6
152
802
J01MA02
ATC
ciprofloxacin; systemic
1.5
11.5
491
3671
R53
ICD-10 Finland
Malaise and fatigue
1.7
11.3
261
1666
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
25.2
11.1
15
6
N03AX16
ATC
pregabalin; oral
1.6
11.1
293
1939
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
2.9
11.1
68
244
ZX108
NOMESCO Finland
Inhalation
8.6
11.0
23
27
N05AA02
ATC
levomepromazine; systemic
2.8
11.0
69
252
L01EL01
ATC
ibrutinib; oral
43.7
10.9
13
*
J01CA04
ATC
amoxicillin; systemic
1.5
10.9
1034
9125
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
10.9
432
3165
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
10.8
414
3007
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
28.3
10.7
14
5
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.1
10.7
131
670
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
10.7
93
407
120
Kela drug reimbursment
Hypogammaglobulinaemia
60.5
10.6
12
*
ZX112
NOMESCO Finland
Subcutaneous
4.1
10.6
40
100
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
10.5
187
1099
WW302
NOMESCO Finland
Allogenic transfer of stem cells from relative
110.8
10.4
11
*
L01EA03
ATC
nilotinib; oral
+∞
10.4
10
*
328
Kela drug reimbursment
Nilotinib
+∞
10.4
10
*
R06.0
ICD-10 Finland
Dyspnoea
1.6
10.3
313
2142
J02AC03
ATC
voriconazole; systemic
32.8
10.3
13
*
JN6AD
NOMESCO Finland
CT of torso and neck
6.1
10.3
27
45
ZY010
NOMESCO Finland
Hospital outpatient
2.7
10.3
68
256
N05BA01
ATC
diazepam; systemic, rectal
1.8
10.2
173
1001
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.2
10.1
52
167
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.1
10.1
114
565
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
10.1
255
1664
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
10.0
497
3806
N02AX02
ATC
tramadol; systemic, rectal
1.5
10.0
525
4069
D47.3
ICD-10 Finland
Essential (haemorrhagic) thrombocythaemia
9.2
10.0
20
22
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
40.4
10.0
12
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.1
9.9
54
181
A46
ICD-10 Finland
Erysipelas
1.8
9.9
185
1103
WX402
NOMESCO Finland
General anaesthesia
1.7
9.9
206
1273
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
26.2
9.8
13
5
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
8.8
9.8
20
23
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
9.6
202
1248
L04AA06
ATC
mycophenolic acid; systemic
4.4
9.5
33
76
C85.9
ICD-10 Finland
Non-Hodgkin lymphoma, unspecified
10.1
9.5
18
18
324
Kela drug reimbursment
Dasatinib
100.7
9.4
10
*
1518
Kela drug reimbursment
NA
100.7
9.4
10
*
D75.1
ICD-10 Finland
Secondary polycythaemia
30.2
9.4
12
*
N06AX21
ATC
duloxetine; oral
2.0
9.4
129
692
C83.1
ICD-10 Finland
Mantle cell lymphoma
12.4
9.4
16
13
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
9.4
251
1662
N05CF01
ATC
zopiclone; oral
1.5
9.3
394
2909
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.1
9.2
99
481
L01AA01
ATC
cyclophosphamide; systemic
7.8
9.1
20
26
N05BA04
ATC
oxazepam; oral
1.6
9.1
292
2020
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.1
9.1
48
158
N03AE01
ATC
clonazepam; systemic
2.3
9.1
80
355
R60.0
ICD-10 Finland
Localized oedema
1.9
8.9
139
782
E0000UV
ATC
NA
1.4
8.9
474
3662
B01AB05
ATC
enoxaparin; parenteral
1.5
8.9
369
2710
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
1.9
8.8
131
724
A28
ICPC
Limited function/disability NOS
1.7
8.8
182
1118
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.2
8.7
90
429
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
50.3
8.7
10
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.4
8.7
73
318
XF600
NOMESCO Finland
Bloodpressure measurement
2.2
8.7
90
431
AA1AD
NOMESCO Finland
CT of head and brain
1.5
8.6
285
1985
R03AC02
ATC
salbutamol; inhalant
1.4
8.6
639
5246
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.8
8.5
139
791
SAA03
NOMESCO Finland
Extended examination of mouth
1.4
8.5
454
3499
B99
ICPC
Blood/lymph/spleen disease other
9.0
8.5
17
19
J01AA02
ATC
doxycycline; systemic
1.4
8.5
978
8683
T90
ICPC
Diabetes non-insulin dependent
1.5
8.5
278
1934
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
7.4
8.5
19
26
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
8.5
128
714
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
4.7
8.4
27
58
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
6.7
8.4
20
30
N02AA05
ATC
oxycodone; systemic
1.7
8.4
181
1128
A02BC01
ATC
omeprazole; systemic
1.5
8.3
343
2514
ZXD05
NOMESCO Finland
Urgent procedure
1.5
8.2
391
2948
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
8.2
550
4422
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
8.2
148
873
P01AB01
ATC
metronidazole; oral, rectal
1.4
8.1
464
3621
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.4
8.1
65
274
9960/3-C42.1
ICD-O-3
Myeloproliferative neoplasm, NOS, of bone marrow
33.5
8.1
10
*
SPAT1263
SPAT
Sampling
1.4
7.9
516
4122
C03DA01
ATC
spironolactone; oral
1.8
7.9
130
745
N06AB04
ATC
citalopram; systemic
1.5
7.8
253
1752
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.3
7.8
69
309
C91.4
ICD-10 Finland
Hairy-cell leukaemia
45.2
7.7
9
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.5
7.7
34
99
RS220
NOMESCO Finland
NA
4.6
7.7
25
55
TAB00
NOMESCO Finland
Lumbar puncture
2.4
7.7
60
252
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
7.7
147
882
N03AX12
ATC
gabapentin; oral
1.7
7.7
179
1138
J05AB01
ATC
aciclovir; systemic
1.6
7.7
243
1672
R4120
NOMESCO Finland
Occupational therapy
2.1
7.6
83
408
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.3
7.6
66
293
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.2
7.6
76
360
J01FF01
ATC
clindamycin; systemic
1.5
7.6
331
2445
B03XA02
ATC
darbepoetin alfa; parenteral
3.6
7.6
32
90
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.6
7.6
207
1376
K59.1
ICD-10 Finland
Functional diarrhoea
2.2
7.6
71
327
WD135
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
6.2
7.5
19
31
N05CD07
ATC
temazepam; oral
1.7
7.5
148
899
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
7.5
95
495
B01AB10
ATC
tinzaparin; parenteral
2.0
7.5
89
453
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.6
7.5
222
1502
D47.7
ICD-10 Finland
Other specified neoplasms of uncertain or unknown behaviour of lymphoid, haematopoietic and related tissue
80.5
7.4
8
*
D75.8
ICD-10 Finland
Other specified diseases of blood and blood-forming organs
80.5
7.4
8
*
WW304
NOMESCO Finland
Transfer of stem cells from registered domestic donator
80.5
7.4
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
7.4
164
1027
C85.1
ICD-10 Finland
B-cell lymphoma, unspecified
13.4
7.4
12
9
J10.0
ICD-10 Finland
Influenza with pneumonia, seasonal influenza virus identified
6.0
7.4
19
32
B02.9
ICD-10 Finland
Zoster without complication
2.1
7.4
77
373
UJF32
NOMESCO Finland
Coloscopy
1.5
7.3
311
2282
9831/3-C42.1
ICD-O-3
T-cell large granular lymphocytic leukemia of bone marrow
+∞
7.3
7
*
C91
ICD-10 Finland
Lymphoid leukaemia
+∞
7.3
7
*
9945/3-C42.1
ICD-O-3
Chronic myelomonocytic leukemia, NOS, of bone marrow
+∞
7.3
7
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
9.4
7.3
14
15
H02AB07
ATC
prednisone; oral
1.6
7.2
175
1124
L28
ICPC
Limited function/disability (L)
1.6
7.2
182
1182
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
20.1
7.1
10
5
SPAT1254
SPAT
Administration of medicine
1.6
7.1
178
1154
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
4.3
7.0
24
56
ZXA05
NOMESCO Finland
Left side
1.5
7.0
305
2243
N05AH02
ATC
clozapine; systemic
3.5
7.0
30
86
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.9
7.0
95
511
A02BC05
ATC
esomeprazole; systemic
1.4
6.9
472
3779
J01FA10
ATC
azithromycin; systemic
1.3
6.8
670
5683
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
4.2
6.8
24
58
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
4.5
6.8
22
49
R06AE07
ATC
cetirizine; oral
1.4
6.8
498
4034
WW409
NOMESCO Finland
Other aferesis
40.2
6.8
8
*
N05AH04
ATC
quetiapine; oral
1.6
6.7
182
1204
N06AX11
ATC
mirtazapine; oral
1.4
6.7
361
2766
TPX10
NOMESCO Finland
Implantation of vascular injection port
2.9
6.7
39
139
B25.9
ICD-10 Finland
Cytomegaloviral disease, unspecified
22.6
6.7
9
*
D46.2
ICD-10 Finland
Refractory anaemia with excess of blasts [RAEB]
22.6
6.7
9
*
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
22.6
6.7
9
*
R31
ICD-10 Finland
Unspecified haematuria
1.7
6.7
125
748
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.1
6.7
72
355
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
2.1
6.7
67
320
N03AX09
ATC
lamotrigine; oral
2.3
6.6
56
245
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
6.6
273
1987
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
1.9
6.6
94
516
SPAT1262
SPAT
Handing over of treatment supplies
1.5
6.5
225
1574
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
3.2
6.5
31
97
ZXD10
NOMESCO Finland
Scheduled procedure
1.4
6.5
465
3741
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.2
6.5
23
56
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.4
6.5
52
221
PJA10
NOMESCO Finland
Exploration of lymph nodes
5.1
6.5
19
38
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
3.7
6.5
26
71
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
1.8
6.5
113
661
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
6.5
317
2388
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
6.5
195
1324
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.4
6.5
50
211
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
6.5
209
1444
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.9
6.4
89
482
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.7
6.4
136
843
D69.4
ICD-10 Finland
Other primary thrombocytopenia
70.2
6.4
7
*
B02BX05
ATC
eltrombopag; oral
70.2
6.4
7
*
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
2.5
6.4
46
186
C95.0
ICD-10 Finland
Acute leukaemia of unspecified cell type
14.4
6.4
10
7
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
3.7
6.4
26
72
D07AB08
ATC
desonide; topical
1.7
6.4
129
789
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
2.6
6.4
45
180
Z2445
NOMESCO Finland
Psychologist
2.4
6.3
51
218
RD210
NOMESCO Finland
NA
3.5
6.3
27
78
A06AD11
ATC
lactulose; oral
1.6
6.3
164
1075
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.9
6.3
86
465
R02
ICPC
Shortness of breath/dyspnoea
1.6
6.3
144
912
L01BB02
ATC
mercaptopurine; oral
4.6
6.3
20
44
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.2
6.3
62
294
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
18.1
6.3
9
5
ZX131
NOMESCO Finland
Intrathecal
+∞
6.3
6
*
9875/3-C42.1
ICD-O-3
Chronic myelogenous leukemia, BCR/ABL positive of bone marrow
+∞
6.3
6
*
2888X
ICD-9 Finland
Diseases of white blood cells, Other specified disease of white blood cells[LEUCOCYTOPATHIA ALIA DEFINITA]
+∞
6.3
6
*
WE300
NOMESCO Finland
Profylactive therapy of malignancy with biomoidiers
+∞
6.3
6
*
C84.59
ICD-10 Finland
Other and unspecified T-cell lymphomas
+∞
6.3
6
*
N05BA06
ATC
lorazepam; systemic, sublingual
2.1
6.3
64
308
WW306
NOMESCO Finland
Transfer of stem cells from foreign registered donator
26.8
6.2
8
*
N05AX08
ATC
risperidone; systemic
1.9
6.2
87
473
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.5
6.2
47
194
N07BA03
ATC
varenicline; oral
2.2
6.2
63
300
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.1
190
1300
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
6.1
152
986
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.4
6.1
282
2096
ZXX02
NOMESCO Finland
Extent of procedure, 2 units
3.9
6.1
23
60
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
1.9
6.1
84
456
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
8.6
6.1
12
14
9101
FHL
Bone biopsy
10.1
6.0
11
11
Mortality – FinRegistry
↥Association
Association between endpoint D3_WHITEBLOODCELLNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_WHITEBLOODCELLNAS | 2.642 [2.33, 3.0] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.036 |
During the follow-up period (1.1.1998 — 31.12.2019), 1292 out of 4517 females with D3_WHITEBLOODCELLNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_WHITEBLOODCELLNAS | 2.552 [2.21, 2.94] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1504 out of 4168 males with D3_WHITEBLOODCELLNAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_WHITEBLOODCELLNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.209% | 0.51% |
| 5 | 1.386% | 2.595% |
| 10 | 3.304% | 6.39% |
| 15 | 6.409% | 12.203% |
| 20 | 10.995% | 20.185% |
Relationships between endpoints
↥Index endpoint: D3_WHITEBLOODCELLNAS – Other and unspecified disorders of white blood cells
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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