otosclerosis: Formation of spongy bone in the labyrinth capsule which can progress toward the stapes (stapedial fixation) or anteriorly toward the cochlea leading to conductive, sensorineural, or mixed hearing loss. Several genes are associated with familial otosclerosis with varied clinical signs.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3018 |
4. Check minimum number of eventsNone |
3018 |
5. Include endpointsNone |
3018 |
6. Filter based on genotype QC (FinnGen only) |
3018 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H80-H83
- Name in latin
- Otosclerosis
Similar endpoints
↥List of similar endpoints to
Otosclerosis
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22316 | 13797 | 8374 |
| Only index persons | 20162 | 12689 | 7473 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.40 | 0.23 |
| Only index persons | 0.40 | 0.47 | 0.29 |
| Median age at first event (years) | |||
| Whole population | 46.35 | 46.34 | 46.36 |
| Only index persons | 45.60 | 45.55 | 45.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3018 | 1916 | 1102 |
| Unadjusted period prevalence (%) | 0.59 | 0.65 | 0.49 |
| Median age at first event (years) | 45.51 | 44.37 | 47.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2744
- Matched controls
- 27440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
ZXC10
NOMESCO Finland
Use of laser
40.2
323.0
573
179
DDA00
NOMESCO Finland
Stapedotomy
+∞
323.0
995
*
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
16384.0
323.0
1366
*
H80.1
ICD-10 Finland
Otosclerosis involving oval window, obliterative
+∞
323.0
377
*
38699
ICD-8 Finland
NA
+∞
323.0
552
*
4133
FHL
Stapedectomy sampling
2155.6
323.0
395
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
7.0
323.0
954
1930
DFF00
NOMESCO Finland
Pure tone audiometry
9.0
323.0
763
1126
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
47.9
323.0
513
131
3870A
ICD-9 Finland
Otosclerosis involving oval window, nonobliterative
+∞
323.0
488
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
47.8
323.0
457
114
H80.9
ICD-10 Finland
Otosclerosis, unspecified
4412.8
323.0
1313
5
H80.8
ICD-10 Finland
Other otosclerosis
2538.0
255.0
243
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.9
228.6
905
2503
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
31.3
227.6
307
110
DDB00
NOMESCO Finland
Stapedectomy
+∞
227.3
215
*
UDC00
NOMESCO Finland
Ear microscopy
6.6
175.2
493
878
H80
ICD-10 Finland
Otosclerosis
+∞
168.5
160
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
6.6
155.5
434
757
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
34.3
148.4
195
61
Z97.4
ICD-10 Finland
Presence of external hearing-aid
7.3
129.8
332
506
DC1AD
NOMESCO Finland
Temporalbone CT
23.3
119.9
175
80
DFF15
NOMESCO Finland
Speech audiometry
6.9
111.2
295
470
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
8.7
108.2
245
306
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
6.7
101.1
274
448
R5120
NOMESCO Finland
Preparation of an aid
8.7
90.6
204
251
H81.0
ICD-10 Finland
Ménière disease
35.0
75.3
98
29
H80.20
ICD-10 Finland
Otosclerosis involving round window
+∞
73.2
70
*
YPA00
NOMESCO Finland
Excision of blood vessel for transplantation
+∞
73.2
70
*
H02
ICPC
Hearing complaint
2.9
66.1
448
1711
4139
FHL
Other measure in this category
+∞
64.8
62
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
5.6
64.3
199
381
DAX08
NOMESCO Finland
Fitting of hearing aid
4.9
58.7
205
449
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.7
58.0
436
1764
DDW99
NOMESCO Finland
Other operation on ossicles of ear
+∞
57.5
55
*
H91.9
ICD-10 Finland
Hearing loss, unspecified
4.6
55.6
205
475
N07CA01
ATC
betahistine; oral
3.6
54.8
272
823
DFF10
NOMESCO Finland
Measurement of acoustic impedance (tympanometry and reflex testing)
41.6
52.1
65
16
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
6.2
50.5
141
237
4134
FHL
Interposition, removal of the disk and placing at least another column on top of the window
+∞
50.1
48
*
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
18.8
44.1
68
37
DCD10
NOMESCO Finland
Tympanoplasty
28.4
39.1
53
19
DCA30
NOMESCO Finland
Exploration of middle ear
87.4
38.9
43
5
R5140
NOMESCO Finland
Monitoring the use of the aid
2.4
35.6
328
1462
H81.3
ICD-10 Finland
Other peripheral vertigo
8.0
32.6
75
96
H80.28
ICD-10 Finland
Cochlear otosclerosis
+∞
32.3
31
*
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
2.9
30.0
188
669
SPAT1043
SPAT
Audiometry
2.2
27.8
308
1493
DFE00
NOMESCO Finland
Insertion of cochlear implant
21.4
26.1
38
18
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
262.9
25.7
26
*
H90.2
ICD-10 Finland
Conductive hearing loss, unspecified
14.2
24.8
42
30
H81.2
ICD-10 Finland
Vestibular neuronitis
24.5
24.4
34
14
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
48.8
24.3
29
6
H71
ICD-10 Finland
Cholesteatoma of middle ear
7.8
24.2
56
73
H93.1
ICD-10 Finland
Tinnitus
2.5
23.9
200
844
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
35.3
22.0
28
8
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
115.9
21.6
23
*
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
50.4
21.1
25
5
ZXA05
NOMESCO Finland
Left side
1.6
19.6
672
4702
ZXA00
NOMESCO Finland
Right side
1.5
19.5
719
5118
DFX00
NOMESCO Finland
Connecting cochlear implant
23.8
18.6
26
11
Z97.8
ICD-10 Finland
Presence of other specified devices
15.4
17.9
29
19
TDA90
NOMESCO Finland
Removal wax from ear
5.0
17.9
57
115
H80.2
ICD-10 Finland
Cochlear otosclerosis
+∞
17.7
17
*
WX002
NOMESCO Finland
Sedation and analgesia
1.6
17.4
519
3494
RK520
NOMESCO Finland
NA
9.8
17.1
34
35
H91.1
ICD-10 Finland
Presbycusis
2.4
16.8
149
650
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.1
16.0
180
874
DFF16
NOMESCO Finland
Speech-in-noise audiometry
21.1
16.0
23
11
DDA10
NOMESCO Finland
Exploration of ossicular chain
+∞
15.6
15
*
DDD10
NOMESCO Finland
Interposition between malleus and stapes
45.2
15.1
18
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.8
14.9
98
363
4161
FHL
Exploratory tympanotomy
57.0
14.8
17
*
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
4.8
14.7
48
101
DEA10
NOMESCO Finland
Attico-antrotomy
21.1
14.6
21
10
WX110
NOMESCO Finland
Local anesthesy
1.4
14.5
1677
14611
RK110
NOMESCO Finland
NA
6.1
13.9
37
61
H74.1
ICD-10 Finland
Adhesive middle ear disease
15.8
13.9
22
14
H29
ICPC
Ear symptom/complaint other
1.8
13.9
254
1482
RK320
NOMESCO Finland
NA
5.6
13.6
39
71
DFF59
NOMESCO Finland
Other assessment of balance
7.0
13.3
32
46
RK420
NOMESCO Finland
NA
22.6
12.9
18
8
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
4.3
12.6
46
109
H83.1
ICD-10 Finland
Labyrinthine fistula
+∞
12.5
12
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
4.1
12.4
47
116
3890A
ICD-9 Finland
Deafness, Conductive deafness
37.7
12.2
15
*
R4135
NOMESCO Finland
Rehabilitation for hearing problems
3.5
12.0
54
155
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
3.3
11.7
57
174
1450
FHL
Otomicroscopy
12.6
11.6
20
16
H28
ICPC
Limited function/disability (H)
4.5
11.6
40
90
H83
ICPC
Otosclerosis
+∞
11.5
11
*
Q78.00
ICD-10 Finland
Congenital osteogenesis imperfecta
35.2
11.3
14
*
DCD00
NOMESCO Finland
Myringoplasty
5.6
11.0
31
56
R42
ICD-10 Finland
Dizziness and giddiness
1.5
10.7
458
3313
Z45.3
ICD-10 Finland
Adjustment and management of implanted hearing device
60.2
10.6
12
*
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
3.0
10.0
57
193
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
7.5
9.4
21
28
SPAT1352
SPAT
Inspection, maintenance and instruction for use of hearing aid
3.5
8.6
38
109
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.8
8.4
145
833
DDD00
NOMESCO Finland
Mobilisation of stapes
+∞
8.3
8
*
Q16.3
ICD-10 Finland
Congenital malformation of ear ossicles
+∞
8.3
8
*
H60.3
ICD-10 Finland
Other infective otitis externa
2.6
8.0
55
212
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.8
8.0
48
173
RK120
NOMESCO Finland
NA
7.2
7.9
18
25
H91
ICD-10 Finland
Other hearing loss
4.1
7.9
29
72
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.4
7.8
425
3204
H91.8
ICD-10 Finland
Other specified hearing loss
4.0
7.4
28
71
\1
NOMESCO Finland
NA
80.3
7.4
8
*
4132
FHL
Crurotomy, fork truncation, and partial removal of the tripod plate
+∞
7.3
7
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
15.8
7.2
11
7
Z96.2
ICD-10 Finland
Presence of otological and audiological implants
15.8
7.2
11
7
SPAT1041
SPAT
Comprehensive hearing test
3.1
7.2
36
116
UDC10
NOMESCO Finland
Tympanoscopy
20.1
7.1
10
5
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
4.5
7.1
23
51
XX7FW
NOMESCO Finland
NA
10.9
6.8
12
11
RL210
NOMESCO Finland
NA
5.3
6.8
19
36
38990
ICD-8 Finland
Other deafness, Partialis uni-sive bilateralis
22.6
6.7
9
*
R5599
NOMESCO Finland
Other rehabilitation service
2.2
6.6
62
284
R1210
NOMESCO Finland
Medical assessment of need and possibilities to rehabilitation
3.5
6.4
27
77
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.8
6.3
109
631
DC1AI
NOMESCO Finland
Cone beam CT of ear
18.0
6.3
9
5
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
3.3
6.3
29
89
DDD20
NOMESCO Finland
Interposition between eardrum and footplate of stapes
+∞
6.2
6
*
RK530
NOMESCO Finland
NA
26.7
6.2
8
*
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
6.1
1015
8854
H65.3
ICD-10 Finland
Chronic mucoid otitis media
2.7
6.1
37
136
H81
ICPC
Excessive ear wax
1.4
6.1
344
2609
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
413
3231
1.32
6.15
4.7
4.6
34.0
32.8
%
1.32
270
2160
2759
26758
1.36
5.31
10.8
10.8
25.5
25.8
u/l
0.23
2642
25784
2431
23222
1.24
5.13
5.0
4.9
1.9
2.1
mu/l
0.97
2193
21185
2000
18879
1.18
4.21
4.3
4.2
12.0
12.8
mm/h
1.90
1829
17432
2833
27709
1.37
4.08
20.7
21.7
6.6
6.7
e9/l
2.61
2743
26883
2831
27691
1.36
4.04
20.7
21.7
250.2
252.5
e9/l
1.11
2740
26960
2832
27705
1.36
4.01
20.7
21.7
4.5
4.5
e12/l
0.89
2739
26879
2832
27712
1.36
3.94
20.8
21.8
134.9
134.3
g/l
1.55
2782
27287
2684
26093
1.26
3.82
16.1
16.9
139.9
139.7
mmol/l
3.23
2613
25441
788
6961
1.18
3.75
1.7
1.6
1.3
1.4
mmol/l
0.56
655
5824
1563
14547
1.15
3.74
2.8
2.7
—
—
—
0
0
2627
25495
1.23
3.69
5.2
5.1
2.8
2.8
mmol/l
1.30
2375
23395
2435
23475
1.19
3.57
5.7
5.9
39.1
39.9
mmol/mol
5.29
2212
21654
2338
22484
1.18
3.43
15.4
15.7
39.7
39.4
%
1.05
1636
15696
2686
26172
1.24
3.35
16.4
17.0
4.0
4.0
mmol/l
0.28
2612
25482
2577
25009
1.21
3.33
4.7
4.5
4.7
4.7
mmol/l
0.45
2334
23086
69
1053
0.65
3.22
2.1
2.0
4.9
2.4
ug/l
0.73
58
941
1275
11809
1.14
3.05
5.9
6.1
1.2
1.2
mmol/l
3.46
1125
10692
54
330
1.65
3.04
2.1
2.2
26.3
22.2
mg/l
0.23
15
83
2554
24824
1.19
2.93
4.7
4.5
1.5
1.5
mmol/l
0.68
2299
22779
2470
23978
1.17
2.70
4.1
4.0
1.3
1.3
mmol/l
1.99
2213
21832
2535
24677
1.17
2.59
4.8
4.7
5.9
6.0
mmol/l
4.26
2271
22445
1382
12977
1.12
2.48
6.7
6.9
1.2
1.2
mmol/l
3.63
1145
10952
496
4366
1.16
2.41
1.3
1.3
30.3
35.1
iu/ml
0.44
147
1384
1136
10604
1.11
2.19
2.0
2.0
98.5
95.5
pmol/l
1.25
582
5354
187
1522
1.24
2.15
1.3
1.3
29.4
49.3
au/ml
—
7
75
29
168
1.73
2.07
1.6
1.9
—
—
—
0
0
204
1685
1.23
2.05
2.4
2.4
13.2
25.0
au/ml
—
6
81
244
2885
0.83
2.04
1.7
1.8
—
—
—
0
0
12
256
0.47
1.94
1.3
1.5
6.4
6.4
mmol/l
0.01
12
241
2025
19573
1.11
1.84
4.2
4.1
14.7
14.8
pmol/l
1.34
1819
17749
50
344
1.46
1.80
1.6
1.5
—
—
—
0
0
50
347
1.45
1.73
1.6
1.5
—
—
—
0
0
248
2882
0.85
1.73
1.7
1.7
—
—
—
0
0
2051
19873
1.10
1.69
7.5
7.7
79.5
78.8
u/l
0.21
1905
18709
49
341
1.44
1.68
1.6
1.5
—
—
—
0
0
49
341
1.44
1.68
1.6
1.5
—
—
—
0
0
49
342
1.44
1.66
1.6
1.5
—
—
—
0
0
533
4839
1.12
1.65
1.7
1.8
1031.4
1190.8
nmol/l
4.28
384
3639
50
351
1.43
1.65
1.6
1.5
—
—
—
0
0
119
1474
0.80
1.62
4.0
3.6
104.4
62.9
u/ml
0.45
114
1422
462
4164
1.13
1.62
1.3
1.2
10.8
12.5
u/ml
0.21
174
1593
21
121
1.74
1.58
1.2
1.1
—
—
—
0
0
58
783
0.74
1.54
1.5
1.5
—
—
—
0
0
112
900
1.25
1.52
1.4
1.4
41.3
34.0
iu/l
1.22
103
769
90
704
1.29
1.52
1.2
1.2
6.3
44.2
u/ml
—
8
39
45
629
0.71
1.48
2.6
2.3
156.3
102.8
ug/min
0.28
30
381
1137
11968
0.92
1.45
3.6
4.0
—
—
—
0
0
83
648
1.29
1.43
1.2
1.2
5.8
7.6
u/ml
—
7
70
178
2087
0.84
1.42
2.6
2.7
66.4
64.6
ml/min/173m2
0.28
71
847
321
2865
1.13
1.34
2.1
2.2
128.4
137.3
ug/g
0.14
237
2226
375
4151
0.89
1.34
1.9
1.8
—
—
—
0
0
573
5286
1.10
1.34
1.3
1.2
1.5
1.8
u/ml
0.20
134
1375
11
208
0.53
1.32
2.2
1.7
—
—
—
0
0
747
6982
1.09
1.32
5.3
5.0
2.1
3.0
ug/l
2.71
652
6243
0
41
0.00
1.31
0.0
1.2
—
—
—
0
0
83
659
1.27
1.28
1.2
1.2
5.6
8.4
u/ml
0.51
14
112
2432
23862
1.10
1.28
13.3
13.7
78.9
78.9
ml/min/173m2
0.05
2027
19716
8
35
2.29
1.26
1.1
1.1
—
—
—
0
0
28
186
1.51
1.26
1.1
1.2
—
—
—
0
0
713
6686
1.09
1.17
2.8
2.7
3952.5
5647.1
umol/l
0.53
613
5791
6
126
0.48
1.16
1.3
1.3
—
—
—
0
0
0
33
0.00
1.16
0.0
1.0
—
—
—
0
0
824
7778
1.08
1.15
2.0
2.1
149.8
213.9
u/l
3.13
765
7281
139
1181
1.19
1.15
1.0
1.0
—
—
—
0
0
94
769
1.23
1.15
1.6
1.8
—
—
—
0
0
309
3424
0.89
1.15
5.7
6.0
1.0
1.0
mmol/l
1.23
294
3177
622
6652
0.92
1.13
4.2
4.2
0.0
0.0
estimate
0.14
202
2213
49
642
0.76
1.13
1.2
1.6
—
—
—
0
0
1229
11789
1.07
1.11
5.9
6.1
2.8
2.9
%
0.67
1132
10972
17
104
1.64
1.09
1.2
1.2
—
—
—
0
0
38
511
0.74
1.06
1.3
1.7
0.8
0.8
nmol/l
0.07
30
420
27
187
1.45
1.03
1.1
1.1
—
—
—
0
0
27
187
1.45
1.03
1.1
1.1
—
—
—
0
0
27
187
1.45
1.03
1.1
1.1
—
—
—
0
0
1119
10722
1.07
1.03
2.3
2.3
79.6
78.8
nmol/l
0.47
989
9613
9
47
1.92
1.02
1.0
1.1
—
—
—
0
0
217
1929
1.13
1.02
1.7
1.8
—
—
—
0
0
12
68
1.77
1.00
2.6
2.5
—
—
—
0
0
15
237
0.63
0.99
1.3
1.4
301.3
328.5
u/l
0.13
15
231
35
470
0.74
0.98
1.3
1.5
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
69
848
0.81
0.97
3.4
3.2
0.3
0.4
u/ml
0.43
38
490
1088
10434
1.07
0.97
2.7
2.8
135.7
129.5
ug/l
0.24
995
9634
400
3694
1.10
0.95
1.4
1.4
—
—
—
0
0
60
746
0.80
0.95
1.2
1.1
—
—
—
0
0
7
37
1.89
0.94
9.1
4.4
—
—
—
0
0
1668
16223
1.06
0.94
3.1
3.1
49.1
50.5
u/l
0.25
1546
15016
19
125
1.52
0.94
2.2
1.7
—
—
—
0
0
184
1632
1.14
0.91
1.2
1.2
115.4
153.5
iu/ml
0.81
65
601
499
5333
0.92
0.91
2.8
2.6
4.9
5.9
e6/l
1.53
417
4650
60
741
0.81
0.90
1.2
1.1
—
—
—
0
0
140
1602
0.87
0.90
6.3
7.3
24.7
24.6
mmol/l
0.20
129
1493
31
417
0.74
0.90
1.3
1.5
—
—
—
0
0
26
185
1.41
0.89
1.2
1.2
—
—
—
0
0
52
651
0.80
0.89
1.6
1.8
2.8
4.9
iu/l
3.82
20
221
26
186
1.40
0.87
1.2
1.2
—
—
—
0
0
36
273
1.32
0.85
1.2
1.4
30.7
31.2
u/l
0.04
30
228
17
112
1.52
0.84
2.6
1.9
—
—
—
0
0
17
112
1.52
0.84
2.6
1.9
—
—
—
0
0
20
286
0.70
0.84
1.4
1.4
75614.9
85091.1
e6/l
0.06
11
171
1256
12143
1.06
0.84
6.0
6.2
27.9
27.8
%
0.15
1149
11289
10
57
1.76
0.83
1.4
1.3
—
—
—
0
0
2107
20677
1.06
0.83
17.0
17.9
13.7
13.7
%
1.05
2072
20192
17
113
1.51
0.82
2.6
1.9
—
—
—
0
0
28
375
0.74
0.81
1.4
1.5
—
—
—
0
0
52
642
0.81
0.80
1.5
1.3
—
—
—
0
0
18
122
1.48
0.80
1.4
1.4
—
—
—
0
0
18
122
1.48
0.80
1.4
1.4
—
—
—
0
0
6
33
1.82
0.79
1.2
1.1
—
—
—
0
0
631
5985
1.07
0.78
1.5
1.6
20.6
20.8
nmol/l
0.15
515
5099
201
2223
0.90
0.78
8.2
6.8
1.3
1.4
mmol/l
0.70
195
2140
25
182
1.38
0.77
1.5
1.6
9.5
6.7
u/l
0.26
13
90
199
2201
0.90
0.77
3.8
4.1
1.2
1.2
mmol/l
0.52
166
1920
18
123
1.47
0.77
1.2
1.5
6.9
8.1
ug/l
0.31
18
104
7
125
0.56
0.77
9.0
11.8
137911.7
879.2
nmol/l
—
7
120
63
521
1.21
0.76
1.2
1.2
50.3
44.5
u/ml
—
9
59
17
115
1.48
0.76
1.4
1.3
—
—
—
0
0
1235
11962
1.05
0.76
5.8
6.0
57.1
57.3
%
0.18
1136
11165
266
2894
0.91
0.75
2.0
2.6
1.8
1.8
%
0.07
232
2575
14
209
0.67
0.75
1.7
1.6
—
—
—
0
0
78
660
1.19
0.75
1.8
2.0
11.1
11.8
mg/l
0.38
72
606
20
141
1.42
0.74
1.1
1.0
—
—
—
0
0
2533
25039
1.07
0.73
13.9
14.7
22.5
23.9
mg/l
1.33
1986
19888
606
6373
0.94
0.72
2.2
2.2
2.9
3.0
mg/l
0.38
506
5420
22
159
1.39
0.72
1.3
1.4
—
—
—
0
0
10
60
1.67
0.72
1.0
1.1
—
—
—
0
0
7
40
1.75
0.71
1.7
2.2
13.3
16.7
umol/l
—
7
40
5
26
1.92
0.70
1.0
1.0
—
—
—
0
0
12
182
0.66
0.70
1.3
1.3
13.8
11.8
u/l
0.27
12
170
100
870
1.15
0.70
1.5
1.7
2.5
3.9
mg/l
1.02
71
623
231
2519
0.91
0.70
2.4
2.2
0.2
0.2
g/l
0.14
219
2364
22
160
1.38
0.70
1.3
1.4
—
—
—
0
0
9
58
1.55
0.69
1.0
1.1
—
—
—
0
0
12
181
0.66
0.69
1.2
1.6
—
—
—
0
0
24
319
0.75
0.68
1.4
1.5
1570.6
2202.1
e6/l
0.49
19
235
5
27
1.85
0.68
5.4
4.5
—
—
—
0
0
10
61
1.64
0.68
1.2
1.9
0.8
1.6
mmol/l
—
10
55
54
649
0.83
0.67
1.9
1.6
—
—
—
0
0
12
179
0.67
0.66
1.4
1.4
11.8
13.4
u/l
0.82
12
173
45
549
0.82
0.66
5.2
3.5
27.0
27.6
mg/l
0.04
27
342
11
70
1.57
0.65
1.1
1.1
—
—
—
0
0
66
560
1.18
0.64
1.3
1.3
224.2
225.2
miu/ml
0.01
24
247
204
2223
0.91
0.63
2.4
2.3
8.3
7.1
ug/l
0.27
172
1971
150
1353
1.11
0.62
9.2
9.3
24.1
24.4
mmol/l
0.59
140
1267
53
631
0.84
0.61
1.9
1.7
—
—
—
0
0
6
105
0.57
0.61
1.0
1.1
101.2
92.8
%
—
6
85
22
290
0.76
0.61
1.5
1.5
—
—
—
0
0
108
957
1.13
0.61
3.6
4.0
25.0
24.9
mmol/l
0.03
101
890
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
22
165
1.34
0.60
2.5
2.4
616.1
728.0
e6/l
0.38
12
68
514
5397
0.94
0.60
4.1
4.2
1.0
1.0
kg/l
0.34
69
793
12
80
1.50
0.59
1.0
1.1
—
—
—
0
0
17
232
0.73
0.59
2.0
2.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
19
140
1.36
0.58
2.7
1.8
—
—
—
0
0
19
140
1.36
0.58
2.7
1.8
—
—
—
0
0
19
140
1.36
0.58
2.7
1.8
—
—
—
0
0
19
140
1.36
0.58
2.7
1.8
—
—
—
0
0
37
300
1.24
0.58
1.2
1.2
57.9
56.4
u/l
0.07
24
210
27
343
0.79
0.58
4.3
2.3
182.5
924.1
u/ml
0.46
27
332
79
688
1.15
0.58
1.5
1.4
—
—
—
0
0
45
540
0.83
0.58
3.7
3.2
0.8
0.8
nmol/l
0.23
35
411
104
1168
0.89
0.57
1.5
1.3
—
—
—
0
0
5
86
0.58
0.56
1.0
1.1
—
—
—
0
0
14
99
1.42
0.54
1.3
1.1
139.8
191.5
iu/ml
0.55
14
99
348
3287
1.07
0.53
27.4
24.6
1.4
1.3
inr
0.42
47
456
926
8980
1.04
0.53
3.2
3.4
2.4
2.4
mmol/l
1.75
794
7818
23
178
1.29
0.53
2.5
1.7
4.1
5.3
umol/l
0.64
16
120
73
638
1.15
0.52
1.5
1.3
—
—
—
0
0
205
1900
1.08
0.52
3.1
2.9
10.1
10.6
g/l
0.97
183
1747
29
359
0.81
0.52
1.1
1.5
—
—
—
0
0
62
536
1.16
0.51
1.5
1.4
23.4
31.2
e6/l
0.20
50
405
204
2198
0.92
0.51
3.0
2.9
165.7
198.2
ng/l
0.61
181
2010
56
650
0.86
0.51
3.9
3.3
24.9
25.1
mmol/l
0.11
50
563
30
369
0.81
0.51
1.4
1.6
—
—
—
0
0
62
537
1.16
0.51
1.6
1.4
394.6
957.0
e6/l
0.86
51
429
45
380
1.19
0.50
1.5
1.3
0.8
0.7
nmol/l
0.60
40
363
11
156
0.70
0.49
1.2
1.7
—
—
—
0
0
347
3662
0.94
0.49
2.6
2.6
2.3
2.3
g/l
0.26
332
3396
46
390
1.18
0.49
1.4
1.6
—
—
—
0
0
28
345
0.81
0.49
1.1
1.1
—
—
—
0
0
117
1289
0.90
0.48
2.9
2.8
0.2
0.3
e6/l
0.96
110
1249
11
76
1.45
0.48
2.2
1.8
—
—
—
0
0
585
5628
1.05
0.47
4.7
4.3
22.5
21.5
%
0.88
281
2796
71
625
1.14
0.47
1.1
1.1
—
—
—
0
0
24
299
0.80
0.46
1.4
1.7
—
—
—
0
0
24
299
0.80
0.46
1.0
1.1
—
—
—
0
0
17
221
0.77
0.46
1.2
1.7
—
—
—
0
0
13
176
0.74
0.46
2.3
2.0
—
—
—
0
0
22
276
0.80
0.45
1.5
1.4
—
—
—
0
0
22
276
0.80
0.45
1.5
1.4
—
—
—
0
0
1694
16669
1.04
0.45
4.6
4.6
3000.2
2004.2
e6/l
—
10
244
326
3434
0.94
0.45
2.7
2.7
22.3
22.7
%
0.22
289
2936
7
50
1.40
0.45
1.0
1.1
—
—
—
0
0
22
275
0.80
0.44
1.5
1.4
—
—
—
0
0
22
275
0.80
0.44
1.5
1.4
—
—
—
0
0
84
753
1.12
0.44
1.7
1.7
—
—
—
0
0
10
140
0.71
0.43
1.0
1.2
—
—
—
0
0
12
87
1.38
0.42
1.9
1.5
—
1903858.3
iu/ml
—
0
6
52
453
1.15
0.42
1.3
1.2
—
—
—
0
0
278
2933
0.94
0.41
7.6
7.4
0.9
1.1
mmol/l
0.37
222
2292
8
58
1.38
0.41
1.7
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
14.1
—
—
—
0
0
8
59
1.36
0.41
1.0
1.8
—
—
—
0
0
136
1468
0.92
0.39
1.5
1.5
—
—
—
0
0
48
549
0.87
0.39
1.4
1.3
—
—
—
0
0
48
549
0.87
0.39
1.4
1.3
—
—
—
0
0
19
151
1.26
0.38
2.6
2.3
395.9
510.9
e6/l
0.69
19
128
280
2943
0.95
0.38
7.6
7.4
5.1
5.1
kpa
0.01
272
2815
280
2942
0.95
0.37
7.5
7.4
13.2
12.3
kpa
1.46
272
2814
419
4028
1.05
0.37
1.4
1.4
—
—
—
0
0
50
567
0.88
0.37
1.4
1.5
—
—
—
0
0
10
72
1.39
0.37
2.0
2.3
0.8
1.3
ug/l
—
10
67
110
1192
0.92
0.36
3.6
2.6
1.1
1.2
%
0.89
110
1182
230
2424
0.94
0.35
8.4
8.3
120.5
120.8
g/l
0.10
223
2339
16
126
1.27
0.35
1.0
1.0
—
—
—
0
0
12
156
0.77
0.34
1.2
1.7
—
—
—
0
0
79
867
0.91
0.34
2.1
2.7
—
—
—
0
0
45
509
0.88
0.33
1.5
1.6
—
—
—
0
0
424
4092
1.04
0.33
3.2
3.1
0.8
0.7
ug/l
0.29
273
2764
6
88
0.68
0.33
1.8
1.8
—
—
—
0
0
45
508
0.88
0.32
6.5
5.6
499.4
641.7
iu/ml
—
7
74
18
146
1.23
0.32
2.8
2.4
0.2
0.2
e9/l
0.16
18
128
18
146
1.23
0.32
1.1
1.2
—
—
—
0
0
807
8255
0.97
0.31
3.4
3.2
31.9
37.0
u/l
1.33
769
7836
1138
11182
1.03
0.31
4.6
4.9
35.7
35.3
g/l
2.30
1047
10402
171
1616
1.06
0.30
1.8
1.8
—
—
—
0
0
17
207
0.82
0.30
2.2
1.1
—
—
—
0
0
19
157
1.21
0.29
2.6
2.0
19.4
17.9
nmol/l
0.34
19
146
13
163
0.80
0.29
2.1
1.7
—
—
—
0
0
21
249
0.84
0.29
1.5
1.4
24.8
32.1
%
0.35
14
149
69
753
0.91
0.28
2.1
1.8
—
—
—
0
0
38
429
0.88
0.28
3.7
3.6
3.4
1.4
%
0.87
28
333
80
738
1.09
0.28
1.6
1.9
—
—
—
0
0
1450
14687
0.98
0.28
8.8
9.2
4.0
4.1
e9/l
0.36
1246
12812
144
1523
0.94
0.27
1.8
1.6
—
—
—
0
0
84
779
1.08
0.26
1.3
1.4
308.2
273.0
ug/g
0.80
48
447
283
2938
0.96
0.26
4.4
4.3
234.4
250.1
u/l
1.61
269
2783
19
225
0.84
0.26
1.9
2.1
1.2
2.0
u/field
0.75
13
87
22
257
0.85
0.26
4.8
3.5
58.9
56.3
%
0.33
15
163
77
712
1.08
0.26
1.4
1.6
0.2
0.2
g/l
0.94
70
676
12
95
1.26
0.26
1.0
1.0
—
—
—
0
0
5
71
0.70
0.26
1.2
1.1
—
—
—
0
0
954
9705
0.98
0.26
3.7
3.6
43.3
101.9
ng/l
0.66
661
6762
5
73
0.68
0.26
1.2
1.1
—
—
—
0
0
43
386
1.12
0.26
1.5
1.3
0.5
0.4
nmol/l
—
7
23
278
2678
1.04
0.25
1.6
1.8
1.4
1.5
%
1.41
244
2334
81
872
0.93
0.25
4.5
3.6
46.5
70.4
mg/l
0.63
69
708
16
132
1.21
0.25
1.1
1.1
—
—
—
0
0
180
1887
0.95
0.25
1.7
1.7
—
—
—
0
0
34
383
0.89
0.25
1.1
1.1
2.5
1537.1
iu/ml
—
6
85
34
383
0.89
0.25
1.3
1.1
—
—
—
0
0
167
1590
1.05
0.25
2.9
3.3
4.4
4.4
pmol/l
0.00
144
1411
9
75
1.20
0.25
1.9
1.4
9.6
9.3
ug/l
—
9
75
70
647
1.08
0.24
1.1
1.1
12.3
6.3
u/ml
—
7
73
16
133
1.20
0.24
1.4
1.5
108.4
59.9
pmol/l
—
7
42
214
2054
1.05
0.24
3.8
3.9
94.5
90.9
ng/l
0.18
180
1762
14
115
1.22
0.23
2.7
4.3
—
—
—
0
0
1510
14939
1.02
0.23
4.5
4.7
6.7
6.7
mmol/l
0.17
1410
13980
35
313
1.12
0.23
1.2
1.1
1.4
3.0
u/ml
1.43
13
132
5
39
1.28
0.23
1.2
1.2
—
—
—
0
0
1248
12325
1.02
0.22
5.1
5.1
0.0
0.0
estimate
0.50
208
2287
68
631
1.08
0.22
1.7
1.7
9478.8
13778.3
e6/l
0.73
50
454
101
1071
0.94
0.22
1.8
1.9
40.6
39.1
u/l
0.29
88
949
7
95
0.74
0.22
1.1
2.4
—
33526.1
—
0
15
7
95
0.74
0.22
1.0
1.1
734.3
1631.9
miu/ml
—
7
95
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
15
178
0.84
0.22
1.3
1.3
0.4
1.1
u/ml
—
10
86
1262
12471
1.02
0.21
3.7
3.8
0.0
0.0
estimate
1.06
205
2232
0
11
0.00
0.21
0.0
1.3
—
2.5
—
0
11
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
394
3838
1.03
0.21
1.9
2.1
29.8
29.8
s
0.05
385
3731
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
1.0
1.5
68.0
119.1
ng/l
—
5
43
11
134
0.82
0.20
1.1
1.6
—
—
—
0
0
11
134
0.82
0.20
1.1
1.6
—
—
—
0
0
50
460
1.09
0.20
1.3
1.2
—
—
—
0
0
213
2208
0.96
0.20
2.1
2.9
66.3
66.5
g/l
0.13
187
2021
82
872
0.94
0.20
4.5
3.6
39.2
58.8
mg/l
1.30
70
709
40
364
1.10
0.20
1.3
1.2
2.9
5.0
u/ml
1.01
17
152
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
7.7
—
0
14
789
8016
0.98
0.20
2.4
2.6
58.2
57.9
u/l
0.06
725
7396
11
90
1.22
0.19
1.0
1.7
16.3
15.0
pmol/l
0.26
11
76
51
472
1.08
0.19
1.4
1.4
—
15.8
—
0
9
225
2325
0.97
0.19
2.4
2.2
349.6
370.3
nmol/l
0.94
207
2130
15
175
0.86
0.18
1.5
1.3
12.2
12.5
mmol/l
—
6
55
80
848
0.94
0.18
4.0
3.5
12.6
1.3
ratio
—
7
64
148
1420
1.04
0.18
2.5
2.2
12.5
12.6
nmol/l
0.03
130
1242
23
259
0.89
0.18
4.3
4.0
—
—
—
0
0
815
8033
1.02
0.18
3.1
3.1
7.4
7.2
mmol/l
0.46
671
6737
22
248
0.89
0.18
2.7
2.9
—
—
—
0
0
10
121
0.83
0.18
1.2
2.3
102.9
96.7
%
—
10
112
10
121
0.83
0.18
2.3
2.6
850.5
1185.3
u/ml
—
10
121
49
527
0.93
0.17
1.8
1.7
—
—
—
0
0
7
62
1.13
0.17
1.0
1.6
—
—
—
0
0
64
601
1.07
0.17
1.5
1.4
—
—
—
0
0
930
9416
0.98
0.17
3.9
4.0
—
—
—
0
0
51
547
0.93
0.17
2.5
2.6
16.9
16.0
%
0.84
27
285
390
3984
0.98
0.16
2.5
2.6
13.4
13.0
umol/l
0.65
370
3696
70
741
0.94
0.16
1.3
2.5
0.0
0.0
g/l
0.00
62
684
424
4326
0.98
0.16
2.8
2.7
2.0
1.2
e6/l
0.42
237
2465
8
70
1.14
0.16
1.3
1.1
—
—
—
0
0
30
329
0.91
0.16
1.6
1.5
—
—
—
0
0
71
671
1.06
0.16
1.8
1.7
—
—
—
0
0
612
6216
0.98
0.16
2.2
2.3
—
—
—
0
0
249
2424
1.03
0.16
2.1
2.4
36.2
59.1
u/l
0.60
221
2087
6
78
0.77
0.15
1.2
1.1
—
—
—
0
0
6
79
0.76
0.15
1.2
1.1
—
—
—
0
0
36
332
1.09
0.15
1.4
1.5
51.9
59.3
%
0.43
25
209
20
178
1.12
0.15
2.1
2.0
13.9
13.3
%
—
7
71
46
492
0.93
0.15
1.1
1.2
—
273.3
—
0
12
163
1578
1.03
0.14
3.8
3.8
5.2
5.2
kpa
0.27
149
1464
695
7041
0.98
0.14
3.2
3.1
0.3
0.5
e6/l
1.25
508
5308
410
4029
1.02
0.13
2.9
2.9
3.5
2.9
e6/l
0.32
218
2182
113
1172
0.96
0.13
1.6
1.8
1.7
1.6
g/l
0.47
99
1009
70
734
0.95
0.13
1.3
2.5
0.0
0.0
g/l
0.00
62
683
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
16
142
1.13
0.12
1.1
1.1
—
—
—
0
0
44
414
1.06
0.12
1.4
1.4
115.5
120.8
u/ml
—
10
80
15
133
1.13
0.12
1.0
1.4
21.1
23.4
umol/l
0.12
15
125
40
376
1.06
0.11
1.2
1.2
1.5
3.6
u/ml
1.39
17
124
502
4953
1.02
0.11
3.3
3.6
290.5
412.0
ng/l
0.68
383
3914
149
1449
1.03
0.11
1.7
1.7
—
—
—
0
0
45
425
1.06
0.11
1.3
1.2
278.9
274.2
u/ml
0.04
32
257
101
977
1.03
0.10
2.0
1.8
—
—
—
0
0
58
554
1.05
0.10
2.7
3.1
1.8
1.5
mmol/l
0.33
58
538
26
280
0.93
0.10
1.4
1.5
0.3
0.3
nmol/l
0.23
19
204
158
1616
0.98
0.09
9.1
8.8
0.7
0.7
%
0.35
158
1604
48
458
1.05
0.09
1.6
1.9
520.9
2429.8
u/l
2.04
20
178
34
360
0.94
0.09
1.2
1.4
—
—
—
0
0
24
223
1.08
0.09
1.6
1.5
—
—
—
0
0
86
888
0.97
0.09
2.2
2.2
228.4
751.2
ug/l
1.50
75
836
76
734
1.04
0.09
1.4
1.6
1.2
1.2
g/l
0.29
70
699
11
97
1.13
0.09
1.9
2.0
20.5
17.8
ug/l
0.20
11
86
153
1496
1.02
0.09
3.7
3.7
1.4
1.9
mmol/l
1.14
118
1136
21
194
1.08
0.09
1.6
1.5
1.0
1.0
g/l
0.15
21
194
10
113
0.88
0.08
1.2
1.1
—
11.2
u/ml
—
0
13
297
2928
1.02
0.08
2.6
2.7
7.2
7.8
umol/l
0.22
253
2551
41
430
0.95
0.08
1.2
1.3
40.9
37.3
u/l
0.08
31
370
5
62
0.81
0.08
1.0
1.1
—
—
—
0
0
54
519
1.04
0.08
2.9
3.8
56.4
57.3
%
0.22
54
519
17
156
1.09
0.08
1.1
1.0
—
—
—
0
0
545
5501
0.99
0.08
1.7
1.8
1.6
1.2
mg/l
0.49
410
4252
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
6
70
0.86
0.07
1.2
1.1
114.3
104.4
%
—
6
62
6
74
0.81
0.07
1.2
1.1
—
—
—
0
0
28
264
1.06
0.07
2.4
1.7
—
—
—
0
0
6
75
0.80
0.07
2.2
1.7
—
—
—
0
0
87
846
1.03
0.07
1.4
1.6
—
371.2
—
0
41
428
4237
1.01
0.07
3.5
3.4
0.8
0.8
mmol/l
0.38
402
3958
23
245
0.94
0.07
6.0
4.9
639.8
49.6
u/ml
—
8
70
73
752
0.97
0.07
2.1
2.0
92.9
90.4
%
0.49
67
707
61
590
1.03
0.07
1.9
1.6
301.9
308.4
mu/l
0.07
55
535
227
2303
0.98
0.07
4.1
3.8
2.0
2.0
mmol/l
0.00
182
1888
72
699
1.03
0.07
1.2
1.2
—
—
—
0
0
160
1628
0.98
0.06
8.9
8.7
1.2
1.3
%
1.29
160
1619
17
183
0.93
0.06
1.0
1.0
553.4
314.5
ng/l
—
10
117
9
101
0.89
0.06
1.2
1.4
—
—
—
0
0
77
751
1.03
0.06
1.3
1.3
—
—
—
0
0
231
2282
1.01
0.05
6.5
7.8
8.8
10.1
mmol/l
2.14
223
2184
25
237
1.06
0.05
2.4
1.6
—
—
—
0
0
25
237
1.06
0.05
2.4
1.6
—
—
—
0
0
25
237
1.06
0.05
2.4
1.6
—
—
—
0
0
1353
13484
1.01
0.05
6.1
6.3
11.3
11.3
umol/l
0.00
1281
12811
101
990
1.02
0.05
1.9
2.5
3.1
3.1
g/l
0.15
73
782
288
2851
1.01
0.05
3.8
4.1
21.2
22.6
ug/l
0.04
244
2314
21
222
0.95
0.05
1.0
1.0
—
—
—
0
0
107
1051
1.02
0.05
1.8
2.5
3.7
3.8
g/l
0.52
71
764
557
5604
0.99
0.05
1.6
1.7
48655131.7
33599572.1
pmol/l
0.22
446
4640
81
827
0.98
0.04
1.3
2.4
38.4
37.7
g/l
0.48
65
715
46
474
0.97
0.04
1.9
1.7
—
—
—
0
0
107
1052
1.02
0.04
1.8
2.5
7.6
7.4
g/l
0.38
75
802
107
1052
1.02
0.04
1.8
2.5
—
—
—
0
0
327
3244
1.01
0.04
6.9
7.0
—
—
—
0
0
1232
12283
1.01
0.04
3.7
3.8
0.0
0.0
estimate
0.00
198
2248
32
332
0.96
0.04
1.5
1.7
—
—
—
0
0
105
1067
0.98
0.04
2.4
1.9
—
—
—
0
0
92
904
1.02
0.04
1.8
2.6
0.4
1.0
g/l
1.42
74
790
20
190
1.05
0.04
1.0
1.3
—
—
—
0
0
14
131
1.07
0.03
2.2
3.6
—
—
—
0
0
17
161
1.06
0.03
1.5
1.2
—
—
—
0
0
269
2709
0.99
0.03
3.0
3.5
—
—
—
0
0
84
853
0.98
0.03
1.3
1.4
—
—
—
0
0
490
4878
1.01
0.03
3.1
3.0
2.5
2.5
mmol/l
0.92
432
4280
11
118
0.93
0.02
2.4
2.4
—
—
—
0
0
99
978
1.01
0.02
1.8
2.5
10.1
10.3
g/l
0.29
76
838
87
859
1.01
0.02
1.7
1.7
—
—
—
0
0
73
740
0.99
0.02
1.6
1.6
0.0
9.2
iu/ml
0.58
14
148
28
272
1.03
0.02
1.0
1.1
—
—
—
0
0
29
282
1.03
0.02
2.3
1.7
—
—
—
0
0
11
103
1.07
0.02
1.1
1.3
—
—
—
0
0
17
163
1.04
0.01
1.5
1.2
—
—
—
0
0
96
969
0.99
0.01
3.9
3.5
32.9
4428.9
u/ml
0.90
84
822
815
8136
1.00
0.01
3.8
4.0
7.7
9.0
mg/mmol
0.29
484
5027
137
1362
1.01
0.01
9.4
10.5
—
—
—
0
0
53
523
1.01
0.01
2.8
3.2
7.3
7.5
mmol/l
0.29
53
510
150
1508
0.99
0.01
1.3
1.3
162.6
203.1
u/ml
0.58
137
1382
36
366
0.98
0.00
1.1
1.1
0.3
1.8
u/ml
2.05
14
138
36
366
0.98
0.00
1.2
1.1
—
—
—
0
0
117
1176
0.99
0.00
4.6
4.1
24.1
24.2
mmol/l
0.06
110
1055
18
185
0.97
0.00
1.0
1.0
61.9
45.2
ng/l
0.59
11
115
19
195
0.97
0.00
1.2
1.1
—
—
—
0
0
24
235
1.02
0.00
2.3
1.6
—
—
—
0
0
29
285
1.02
0.00
1.1
1.3
7.5
7.4
mmol/l
0.00
20
212
25
251
1.00
0.00
1.4
1.3
—
—
—
0
0
35
349
1.00
0.00
1.1
1.1
—
—
—
0
0
56
561
1.00
0.00
2.0
2.3
132.9
128.4
g/l
0.63
36
411
103
1035
0.99
0.00
5.3
6.0
1.4
1.6
%
1.17
97
969
11
114
0.96
0.00
8.8
11.3
0.5
0.6
mmol/l
0.70
11
106
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
10
102
0.98
0.00
1.4
2.3
122.6
157.2
%
—
10
94
17
172
0.99
0.00
1.4
1.5
—
—
—
0
0
20
198
1.01
0.00
1.2
1.2
68.0
117.9
titre
—
5
38
79
794
0.99
0.00
1.4
2.5
0.0
0.0
g/l
0.00
71
733
22
222
0.99
0.00
2.8
1.9
2.9
4.2
mg/l
1.97
22
216
22
222
0.99
0.00
1.1
1.1
—
—
—
0
0
24
242
0.99
0.00
1.3
1.5
—
—
—
0
0
31
308
1.01
0.00
1.7
1.8
19.4
24.1
ug/l
0.45
31
302
748
7484
1.00
0.00
2.9
3.0
1487.1
1405.6
ng/l
0.11
619
6438
46
463
0.99
0.00
1.5
1.3
12.7
12.0
u/l
0.11
35
368
18
183
0.98
0.00
1.0
1.0
496.5
707.2
ng/l
—
10
115
0
6
0.00
0.00
0.0
1.2
—
1.3
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
1.2
—
0
6
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
22
220
1.00
0.00
1.1
1.3
—
—
—
0
0
7
73
0.96
0.00
1.7
2.9
—
—
—
0
0
8
85
0.94
0.00
1.1
1.3
3.9
3.9
umol/l
—
8
79
7
73
0.96
0.00
1.7
2.9
—
—
—
0
0
17
170
1.00
0.00
1.2
1.1
31.4
43.4
mg/l
0.97
12
146
0
8
0.00
0.00
0.0
1.5
—
2.1
—
0
8
5
59
0.85
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
7
79
0.89
0.00
2.7
2.2
20.3
28.9
%
—
7
71
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
0.00
1.3
1.2
—
—
—
0
0
6
60
1.00
0.00
1.0
1.3
—
—
—
0
0
7
78
0.90
0.00
1.6
2.4
124.7
174.8
%
—
7
70
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_OTOSCLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTOSCLE | 0.764 [0.69, 0.85] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 728 out of 7721 females with H8_OTOSCLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTOSCLE | 0.687 [0.62, 0.76] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.07 |
During the follow-up period (1.1.1998 — 31.12.2019), 547 out of 4710 males with H8_OTOSCLE died.
Mortality risk
Mortality risk for people of age
years, who have H8_OTOSCLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.179% |
| 5 | 0.418% | 0.94% |
| 10 | 1.008% | 2.26% |
| 15 | 1.966% | 4.465% |
| 20 | 3.456% | 7.889% |
Relationships between endpoints
↥Index endpoint: H8_OTOSCLE – Otosclerosis
GWS hits: 40
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data