otosclerosis: Formation of spongy bone in the labyrinth capsule which can progress toward the stapes (stapedial fixation) or anteriorly toward the cochlea leading to conductive, sensorineural, or mixed hearing loss. Several genes are associated with familial otosclerosis with varied clinical signs.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
3043 |
4. Check minimum number of eventsNone |
3043 |
5. Include endpointsNone |
3043 |
6. Filter based on genotype QC (FinnGen only) |
2946 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H80-H83
- Name in latin
- Otosclerosis
Similar endpoints
↥List of similar endpoints to
Otosclerosis
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22316 | 13797 | 8374 |
| Only index persons | 20162 | 12689 | 7473 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.33 | 0.40 | 0.23 |
| Only index persons | 0.40 | 0.47 | 0.29 |
| Median age at first event (years) | |||
| Whole population | 46.35 | 46.34 | 46.36 |
| Only index persons | 45.60 | 45.55 | 45.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2946 | 1879 | 1067 |
| Unadjusted period prevalence (%) | 0.60 | 0.67 | 0.49 |
| Median age at first event (years) | 45.59 | 44.49 | 47.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3043
- Matched controls
- 30430
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.5
321.2
1070
3252
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
16384.0
307.7
1523
*
3870A
ICD-9 Finland
Otosclerosis involving oval window, nonobliterative
+∞
307.7
537
*
H80.9
ICD-10 Finland
Otosclerosis, unspecified
13406.2
307.7
1465
*
ZXC10
NOMESCO Finland
Use of laser
32.4
307.7
627
242
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
41.3
307.7
598
179
38699, ,
ICD-8 Finland
+∞
307.7
604
*
DFF00
NOMESCO Finland
Pure tone audiometry
8.1
307.7
963
1638
H80.1
ICD-10 Finland
Otosclerosis involving oval window, obliterative
+∞
307.7
410
*
DDA00
NOMESCO Finland
Stapedotomy
5562.5
307.7
1125
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
30.7
307.7
220
77
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
34.7
307.7
351
114
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.3
307.7
1100
2491
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
54.2
307.7
519
115
4133
FHL
Stapedectomy sampling
+∞
307.7
437
*
UDC00
NOMESCO Finland
Ear microscopy
6.4
306.0
577
1074
H80.8
ICD-10 Finland
Other otosclerosis
+∞
280.7
265
*
DC1AD
NOMESCO Finland
Temporalbone CT
24.1
278.8
201
89
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
6.0
265.0
524
1015
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.9
251.1
419
684
DDB00
NOMESCO Finland
Stapedectomy
+∞
246.3
233
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
7.5
220.2
334
490
H80
ICD-10 Finland
Otosclerosis
2024.2
208.7
200
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.8
192.4
384
742
DFF15
NOMESCO Finland
Speech audiometry
5.7
184.4
373
729
Z3229
NOMESCO Finland
Other healthcare associate professional
4.4
180.9
518
1354
H81.0
ICD-10 Finland
Ménière disease
28.8
169.8
114
41
R5120
NOMESCO Finland
Preparation of an aid
6.6
146.5
246
399
DAX08
NOMESCO Finland
Fitting of hearing aid
4.6
132.7
340
807
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
17.7
107.8
88
51
H02
ICPC
Hearing complaint
2.8
98.4
608
2517
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
4.8
94.8
226
503
DCD10
NOMESCO Finland
Tympanoplasty
38.7
92.7
57
15
YPA00
NOMESCO Finland
Excision of blood vessel for transplantation
915.3
91.3
89
*
H80.20
ICD-10 Finland
Otosclerosis involving round window
+∞
87.9
84
*
N07CA01
ATC
betahistine; oral
3.4
78.7
303
951
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.8
78.5
185
407
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.8
77.7
256
725
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
72.1
511
2237
DFF10
NOMESCO Finland
Measurement of acoustic impedance (tympanometry and reflex testing)
85.5
67.3
75
9
4139
FHL
Other measure in this category
+∞
66.9
64
*
H81.3
ICD-10 Finland
Other peripheral vertigo
8.9
66.1
83
96
DFE00
NOMESCO Finland
Insertion of cochlear implant
22.2
62.4
46
21
DDW99
NOMESCO Finland
Other operation on ossicles of ear
308.4
59.5
60
*
H90.2
ICD-10 Finland
Conductive hearing loss, unspecified
13.3
58.0
55
42
4134
FHL
Interposition, removal of the disk and placing at least another column on top of the window
+∞
57.5
55
*
DCA30
NOMESCO Finland
Exploration of middle ear
99.6
44.9
49
5
R5140
NOMESCO Finland
Monitoring the use of the aid
2.2
43.1
391
1884
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
2.6
39.0
235
940
H71
ICD-10 Finland
Cholesteatoma of middle ear
6.1
36.7
64
107
H80.28
ICD-10 Finland
Cochlear otosclerosis
+∞
36.5
35
*
RK520, ,
NOMESCO Finland
11.7
36.1
37
32
SPAT1043
SPAT
Audiometry
2.1
32.7
354
1818
H93.1
ICD-10 Finland
Tinnitus
2.4
31.4
235
1038
DE2CG
NOMESCO Finland
Acoustic channel extensive MRI examination with high intensity magnet
5.4
30.4
60
113
H81.2
ICD-10 Finland
Vestibular neuronitis
27.5
28.0
38
14
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
101.0
27.7
30
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
37.1
26.1
33
9
TDA90
NOMESCO Finland
Removal wax from ear
4.4
25.3
64
149
RK320, ,
NOMESCO Finland
6.0
24.3
43
73
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
3.7
24.0
75
204
H29
ICPC
Ear symptom/complaint other
1.9
23.9
349
1978
Z97.8
ICD-10 Finland
Presence of other specified devices
7.7
23.8
33
43
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
65.5
22.8
26
*
DFF59
NOMESCO Finland
Other assessment of balance
6.0
21.7
38
64
DFX00
NOMESCO Finland
Connecting cochlear implant
20.2
21.7
32
16
RK110, ,
NOMESCO Finland
5.6
21.3
40
72
DCD00
NOMESCO Finland
Myringoplasty
6.0
21.2
37
62
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
2.8
21.2
109
402
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
34.0
21.1
27
8
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
21.6
20.8
30
14
ZXA05
NOMESCO Finland
Left side
1.5
20.8
746
5330
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
8.7
20.7
26
30
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
4.1
19.7
54
134
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
4.1
19.4
53
131
R4135
NOMESCO Finland
Rehabilitation for hearing problems
3.4
19.3
68
201
H74.1
ICD-10 Finland
Adhesive middle ear disease
8.4
19.3
25
30
H28
ICPC
Limited function/disability (H)
4.2
19.1
51
124
H80.2
ICD-10 Finland
Cochlear otosclerosis
+∞
18.8
18
*
DDD10
NOMESCO Finland
Interposition between malleus and stapes
191.1
18.5
19
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.0
18.4
211
1102
DFF16
NOMESCO Finland
Speech-in-noise audiometry
17.7
18.2
28
16
ZXA00
NOMESCO Finland
Right side
1.5
18.2
786
5810
DEA10
NOMESCO Finland
Attico-antrotomy
24.2
17.3
24
10
H91.8
ICD-10 Finland
Other specified hearing loss
4.2
16.7
44
106
DDA10
NOMESCO Finland
Exploration of ossicular chain
+∞
16.7
16
*
WX002
NOMESCO Finland
Sedation and analgesia
1.5
16.5
571
4026
ZXD20
NOMESCO Finland
Day surgery
1.6
16.0
370
2375
4161
FHL
Exploratory tympanotomy
47.8
16.0
19
*
Q78.00
ICD-10 Finland
Congenital osteogenesis imperfecta
85.5
15.6
17
*
H91.1
ICD-10 Finland
Presbycusis
1.9
14.6
185
1000
R42
ICD-10 Finland
Dizziness and giddiness
1.5
14.1
562
4061
DFX03
NOMESCO Finland
Review, maintenance and user education for hearing aid
5.7
14.1
26
46
3890A
ICD-9 Finland
Deafness, Conductive deafness
53.6
13.8
16
*
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
4.3
13.6
34
79
H83.1
ICD-10 Finland
Labyrinthine fistula
+∞
13.5
13
*
H83
ICPC
Otosclerosis
+∞
13.5
13
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
13.0
1959
17460
RK420, ,
NOMESCO Finland
14.4
12.3
20
14
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
12.2
995
8095
SPAT1352
SPAT
Inspection, maintenance and instruction for use of hearing aid
3.1
11.9
48
155
DE2BG
NOMESCO Finland
Acoustic channel MRI examination with high intensity magnet
3.7
11.9
37
101
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
11.9
1053
8659
DDD00
NOMESCO Finland
Mobilisation of stapes
+∞
11.5
11
*
H81
ICPC
Excessive ear wax
1.5
11.4
457
3300
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.9
11.2
52
183
H60.3
ICD-10 Finland
Other infective otitis externa
2.4
10.8
69
286
Z45.3
ICD-10 Finland
Adjustment and management of implanted hearing device
28.1
10.7
14
5
H91
ICD-10 Finland
Other hearing loss
3.4
10.7
37
109
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.4
10.4
488
3623
UDC10
NOMESCO Finland
Tympanoscopy
32.6
10.3
13
*
RL210, ,
NOMESCO Finland
5.3
10.1
20
38
1450
FHL
Otomicroscopy
9.1
10.0
20
22
H66.0
ICD-10 Finland
Acute suppurative otitis media
1.8
9.9
154
889
DC1AI
NOMESCO Finland
Cone beam CT of ear
26.1
9.8
13
5
H61.2
ICD-10 Finland
Impacted cerumen
1.7
9.8
177
1065
H65.3
ICD-10 Finland
Chronic mucoid otitis media
2.8
9.4
44
156
RK120, ,
NOMESCO Finland
8.3
9.1
19
23
Z96.2
ICD-10 Finland
Presence of otological and audiological implants
24.1
8.9
12
5
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.7
8.9
177
1094
ZXE00
NOMESCO Finland
One hour or less
1.3
8.4
1015
8600
H90
ICD-10 Finland
Conductive and sensorineural hearing loss
6.7
8.3
20
30
\1, ,
NOMESCO Finland
+∞
8.3
8
*
H91.2
ICD-10 Finland
Sudden idiopathic hearing loss
2.2
7.9
62
282
H13
ICPC
Plugged feeling ear
1.4
7.9
483
3731
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
7.6
1138
9855
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
2.0
7.5
75
376
R5599
NOMESCO Finland
Other rehabilitation service
2.0
7.5
75
376
H60.8
ICD-10 Finland
Other otitis externa
2.0
7.4
75
377
SPAT1041
SPAT
Comprehensive hearing test
2.7
7.3
38
143
4132
FHL
Crurotomy, fork truncation, and partial removal of the tripod plate
+∞
7.3
7
*
TDB00
NOMESCO Finland
Removal of foreign body from external auditory canal
+∞
7.3
7
*
RK530, ,
NOMESCO Finland
20.1
7.1
10
5
4122
FHL
Tympanostomy (tympanic tube)
4.1
7.1
19
47
Q16.3
ICD-10 Finland
Congenital malformation of ear ossicles
40.1
6.8
8
*
S02CA03
ATC
hydrocortisone and antiinfectives; otic
12.3
6.6
11
9
DDD20
NOMESCO Finland
Interposition between eardrum and footplate of stapes
70.0
6.4
7
*
H66.9
ICD-10 Finland
Otitis media, unspecified
1.7
6.4
121
740
SFA20
NOMESCO Finland
Two-surface restoration
1.2
6.3
1491
13460
38790
ICD-8 Finland
Other disease of ear and mastoid process, Degeneratio nervi acustici
11.0
6.3
11
10
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.2
6.2
1417
12735
H92.0
ICD-10 Finland
Otalgia
1.6
6.2
133
841
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
5.0
6.2
18
36
N05AB04
ATC
prochlorperazine; systemic, rectal
2.1
6.1
54
259
XX7FW, ,
NOMESCO Finland
8.6
6.0
12
14
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
10.0
6.0
11
11
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
6.0
1876
17354
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
417
3254
1.33
6.32
4.6
4.6
33.87
32.82
%
1.06
272
2195
2459
23482
1.25
5.30
5.0
4.9
1.92
2.07
mu/l
0.95
2221
21435
2781
26980
1.36
5.25
10.7
10.8
25.59
25.74
u/l
0.16
2663
25995
2012
19009
1.17
4.11
4.3
4.2
12.00
12.83
mm/h
1.85
1840
17545
2855
27930
1.36
4.03
20.6
21.7
250.24
252.47
e9/l
1.09
2763
27198
2856
27944
1.36
4.00
20.6
21.7
4.47
4.45
e12/l
0.88
2762
27117
795
6994
1.19
4.00
1.7
1.6
1.34
1.38
mmol/l
0.64
662
5848
2856
27951
1.35
3.93
20.7
21.8
134.90
134.30
g/l
1.55
2805
27525
2855
27941
1.35
3.92
20.6
21.7
6.56
6.70
e9/l
2.53
2764
27114
2704
26301
1.25
3.71
16.1
16.9
139.87
139.69
mmol/l
3.37
2633
25649
1578
14697
1.15
3.71
2.8
2.7
—
—
—
0
0
2452
23643
1.19
3.55
5.6
5.8
39.12
39.91
mmol/mol
5.02
2226
21805
2646
25701
1.23
3.52
5.2
5.0
2.81
2.77
mmol/l
1.24
2398
23603
2847
27913
1.31
3.32
20.8
21.7
40.11
39.87
%
1.23
2631
26052
69
1058
0.64
3.29
2.1
2.0
4.91
2.37
ug/l
0.74
58
945
1284
11859
1.14
3.26
5.8
6.1
1.22
1.21
mmol/l
3.64
1142
10815
2706
26381
1.23
3.25
16.3
17.0
3.97
3.97
mmol/l
0.22
2632
25691
2595
25209
1.20
3.15
4.7
4.5
4.72
4.71
mmol/l
0.40
2353
23286
54
330
1.65
3.04
2.1
2.2
26.27
22.21
mg/l
0.23
15
83
2573
25025
1.18
2.83
4.7
4.5
1.51
1.50
mmol/l
0.68
2319
22983
500
4375
1.17
2.62
1.3
1.3
29.88
34.01
iu/ml
0.38
156
1422
2488
24169
1.16
2.61
4.1
4.0
1.26
1.29
mmol/l
2.05
2230
22004
2555
24879
1.17
2.56
4.8
4.7
5.86
5.95
mmol/l
3.85
2290
22629
1390
13041
1.12
2.54
6.6
6.9
1.22
1.22
mmol/l
4.08
1160
11080
192
1536
1.27
2.51
1.3
1.3
30.14
53.57
au/ml
—
9
93
209
1698
1.25
2.40
2.4
2.4
19.57
25.01
au/ml
—
10
114
244
2892
0.83
2.09
1.7
1.8
—
—
—
0
0
1141
10676
1.11
2.07
2.0
2.0
98.42
95.54
pmol/l
1.22
583
5374
12
256
0.47
1.94
1.3
1.5
6.37
6.38
mmol/l
0.01
12
241
29
172
1.69
1.93
1.6
1.7
—
—
—
0
0
93
708
1.32
1.84
1.3
1.2
5.60
45.28
u/ml
—
9
38
467
4175
1.14
1.84
1.3
1.2
10.65
12.35
u/ml
0.22
177
1600
248
2889
0.85
1.78
1.7
1.7
—
—
—
0
0
2038
19727
1.10
1.72
4.2
4.1
14.72
14.84
pmol/l
1.32
1831
17897
50
348
1.44
1.71
1.6
1.5
—
—
—
0
0
120
1491
0.80
1.67
4.0
3.6
103.60
62.57
u/ml
0.45
115
1437
50
351
1.43
1.65
1.6
1.5
—
—
—
0
0
85
652
1.31
1.63
1.2
1.2
5.84
7.59
u/ml
—
7
70
535
4868
1.12
1.60
1.7
1.7
1031.54
1189.35
nmol/l
4.23
385
3661
49
345
1.43
1.60
1.6
1.5
—
—
—
0
0
49
345
1.43
1.60
1.6
1.5
—
—
—
0
0
2063
20013
1.10
1.59
7.5
7.8
79.47
78.80
u/l
0.20
1918
18863
49
346
1.42
1.57
1.6
1.5
—
—
—
0
0
50
355
1.42
1.56
1.6
1.5
—
—
—
0
0
2235
21772
1.10
1.55
16.5
17.4
15.20
15.08
%
0.39
2201
21356
85
663
1.29
1.47
1.2
1.2
5.57
8.58
u/ml
0.54
14
112
46
638
0.72
1.45
2.5
2.2
151.39
102.87
ug/min
0.26
31
386
60
798
0.75
1.45
1.5
1.5
—
—
—
0
0
375
4169
0.89
1.43
1.9
1.8
—
—
—
0
0
21
125
1.68
1.43
1.2
1.2
—
—
—
0
0
29
188
1.55
1.42
1.2
1.1
—
—
—
0
0
29
188
1.55
1.42
1.2
1.1
—
—
—
0
0
29
188
1.55
1.42
1.2
1.1
—
—
—
0
0
751
6998
1.10
1.42
5.4
5.0
2.13
3.00
ug/l
2.67
656
6253
180
2107
0.85
1.41
2.5
2.7
66.40
64.53
ml/min/173m2
0.32
72
855
832
7800
1.09
1.38
2.0
2.1
149.48
214.89
u/l
3.27
773
7300
112
912
1.24
1.38
1.4
1.4
41.27
34.21
iu/l
1.17
103
780
511
4681
1.11
1.36
1.5
1.5
2.49
2.46
g/l
0.07
305
2800
11
209
0.52
1.34
2.0
1.6
—
—
—
0
0
60
785
0.76
1.32
3.4
3.9
3.93
3.87
mmol/l
0.48
60
779
1151
12073
0.92
1.31
2.4
2.6
—
—
—
0
0
577
5335
1.10
1.29
1.3
1.2
1.53
1.76
u/ml
0.20
134
1381
2457
24111
1.10
1.28
13.2
13.7
79.01
78.99
ml/min/173m2
0.02
2052
19948
8
35
2.29
1.26
1.1
1.1
—
—
—
0
0
28
186
1.51
1.26
1.2
1.2
—
—
—
0
0
28
187
1.50
1.23
1.2
1.1
—
—
—
0
0
28
187
1.50
1.23
1.1
1.2
—
—
—
0
0
311
3459
0.89
1.22
5.7
5.9
1.01
1.04
mmol/l
1.23
296
3210
95
773
1.24
1.21
1.6
1.7
—
—
—
0
0
322
2897
1.12
1.20
2.1
2.2
127.94
138.35
ug/g
0.17
239
2268
49
647
0.75
1.18
1.2
1.6
—
—
—
0
0
0
33
0.00
1.16
0.0
1.0
—
—
—
0
0
6
129
0.46
1.16
1.3
1.3
—
—
—
0
0
38
517
0.73
1.12
1.3
1.7
0.82
0.80
nmol/l
0.06
30
424
1239
11885
1.07
1.11
5.9
6.1
2.80
2.85
%
0.39
1146
11090
17
104
1.64
1.09
1.2
1.2
—
—
—
0
0
716
6736
1.08
1.09
2.8
2.7
3894.33
5718.95
umol/l
0.60
623
5886
25
362
0.69
1.07
1.5
1.5
31.10
32.27
g/l
0.19
25
328
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
69
859
0.80
1.07
3.4
3.2
0.32
0.35
u/ml
0.42
38
500
13
74
1.76
1.06
1.6
1.4
98.02
162.92
nmol/24h
0.33
13
74
20
301
0.66
1.04
1.7
1.5
—
—
—
0
0
20
301
0.66
1.04
1.6
1.5
—
—
—
0
0
60
756
0.79
1.04
1.2
1.1
—
—
—
0
0
628
6688
0.92
1.03
4.2
4.2
0.00
0.00
estimate
0.14
203
2220
5
22
2.27
1.03
1.2
1.2
—
—
—
0
0
188
1653
1.15
1.03
1.2
1.2
123.94
153.63
iu/ml
0.54
66
612
1243
11950
1.07
1.03
6.2
6.4
8.65
8.64
%
0.02
1145
11170
1241
11932
1.07
1.02
15.2
15.1
1.25
1.26
inr
0.17
321
3458
9
47
1.92
1.02
1.0
1.1
—
—
—
0
0
139
1198
1.17
1.00
1.0
1.0
—
—
—
0
0
220
1960
1.13
1.00
1.7
1.8
—
—
—
0
0
60
751
0.79
0.99
1.2
1.1
—
—
—
0
0
15
237
0.63
0.99
1.3
1.4
301.27
328.48
u/l
0.13
15
231
35
470
0.74
0.98
1.3
1.5
—
—
—
0
0
192
2165
0.88
0.98
2.4
2.6
71.05
70.41
e9/l
0.07
141
1651
1099
10540
1.07
0.97
2.7
2.8
135.52
129.47
ug/l
0.24
1004
9727
18
116
1.56
0.96
1.4
1.3
—
—
—
0
0
12
69
1.74
0.96
2.6
2.5
—
—
—
0
0
1199
11535
1.07
0.96
6.0
6.1
0.69
0.68
%
0.27
1101
10744
65
523
1.25
0.96
1.2
1.2
45.34
45.49
u/ml
—
10
58
405
3740
1.10
0.96
1.4
1.4
—
—
—
0
0
26
182
1.43
0.96
1.5
1.6
4.86
7.12
u/l
0.47
21
155
1126
10813
1.07
0.95
2.3
2.3
79.64
78.73
nmol/l
0.50
996
9696
52
657
0.79
0.94
1.6
1.8
2.76
4.83
iu/l
3.78
20
224
7
37
1.89
0.94
9.1
4.4
—
—
—
0
0
19
125
1.52
0.94
2.2
1.7
—
—
—
0
0
1682
16363
1.06
0.93
3.1
3.1
48.99
50.42
u/l
0.25
1560
15140
21
142
1.48
0.92
1.0
1.0
—
—
—
0
0
1269
12245
1.06
0.92
6.0
6.2
27.90
27.81
%
0.10
1175
11467
141
1615
0.87
0.91
6.2
7.3
24.68
24.57
mmol/l
0.12
134
1537
14
219
0.64
0.90
1.7
1.6
—
—
—
0
0
198
2210
0.89
0.88
3.8
4.1
1.23
1.23
mmol/l
0.47
165
1927
20
288
0.69
0.87
1.4
1.4
75614.91
84501.63
e6/l
0.06
11
173
31
414
0.75
0.86
1.3
1.5
—
—
—
0
0
37
282
1.32
0.85
1.2
1.4
30.64
31.43
u/l
0.07
31
234
1248
12065
1.06
0.83
5.8
6.0
57.04
57.26
%
0.25
1152
11282
504
5362
0.93
0.82
2.8
2.6
5.04
5.81
e6/l
1.02
437
4805
28
376
0.74
0.82
1.4
1.5
—
—
—
0
0
10
58
1.73
0.79
1.4
1.3
—
—
—
0
0
17
114
1.49
0.79
2.6
1.9
—
—
—
0
0
17
114
1.49
0.79
2.6
1.9
—
—
—
0
0
6
33
1.82
0.79
1.2
1.1
—
—
—
0
0
634
6015
1.07
0.78
1.5
1.6
20.57
20.77
nmol/l
0.13
518
5121
7
123
0.57
0.77
9.0
11.8
137911.71
884.74
nmol/l
—
7
118
17
115
1.48
0.76
2.6
1.9
—
—
—
0
0
10
59
1.70
0.75
1.0
1.1
—
—
—
0
0
267
2901
0.91
0.74
2.0
2.6
1.82
1.81
%
0.06
233
2579
78
662
1.18
0.73
1.8
2.0
11.15
11.77
mg/l
0.37
72
608
53
644
0.82
0.72
1.5
1.3
—
—
—
0
0
18
125
1.44
0.72
1.4
1.4
—
—
—
0
0
18
125
1.44
0.72
1.2
1.5
6.92
8.57
ug/l
0.45
18
106
18
125
1.44
0.72
1.4
1.4
—
—
—
0
0
24
322
0.74
0.72
1.4
1.4
1570.58
2194.18
e6/l
0.48
19
237
54
654
0.82
0.72
1.9
1.6
—
—
—
0
0
12
76
1.58
0.71
1.3
1.1
—
—
—
0
0
5
26
1.92
0.70
1.0
1.0
—
—
—
0
0
630
6612
0.94
0.70
4.1
3.9
91.07
90.48
%
0.25
622
6434
12
182
0.66
0.70
1.3
1.3
13.75
11.78
u/l
0.27
12
170
611
6417
0.94
0.70
2.2
2.2
2.93
3.02
mg/l
0.43
511
5453
101
881
1.15
0.69
1.5
1.7
2.54
4.13
mg/l
1.31
74
655
104
1186
0.87
0.68
1.5
1.3
—
—
—
0
0
204
2235
0.91
0.68
2.4
2.3
8.32
7.26
ug/l
0.24
172
1979
5
27
1.85
0.68
5.4
4.5
—
—
—
0
0
10
61
1.64
0.68
1.2
1.9
0.80
1.59
mmol/l
—
10
55
7
42
1.67
0.68
1.7
2.4
13.29
16.94
umol/l
—
7
42
9
59
1.53
0.68
1.0
1.1
—
—
—
0
0
12
180
0.67
0.67
1.2
1.6
—
—
—
0
0
12
180
0.67
0.67
1.4
1.4
11.75
13.55
u/l
0.89
12
174
24
179
1.34
0.66
2.5
1.8
4.07
5.27
umol/l
0.62
16
122
2551
25237
1.07
0.66
13.9
14.7
22.41
23.88
mg/l
1.39
2003
20050
22
162
1.36
0.66
1.3
1.4
—
—
—
0
0
53
636
0.83
0.66
1.9
1.7
—
—
—
0
0
11
70
1.57
0.65
1.1
1.1
—
—
—
0
0
45
548
0.82
0.65
5.2
3.5
26.99
27.63
mg/l
0.05
27
339
22
163
1.35
0.64
1.3
1.3
—
—
—
0
0
27
348
0.77
0.63
4.3
2.3
182.49
894.97
u/ml
0.45
27
343
67
571
1.18
0.62
1.3
1.3
224.24
227.05
miu/ml
0.02
24
249
79
683
1.16
0.62
1.5
1.4
—
—
—
0
0
235
2543
0.92
0.62
2.4
2.2
0.21
0.21
g/l
0.07
222
2386
6
105
0.57
0.61
1.0
1.1
101.17
92.23
%
—
6
84
48
398
1.21
0.60
1.5
1.6
—
—
—
0
0
45
543
0.83
0.60
3.7
3.2
0.84
0.80
nmol/l
0.24
35
414
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
17
232
0.73
0.59
2.0
2.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
517
5422
0.94
0.58
4.1
4.2
1.02
1.02
kg/l
0.31
69
804
589
5638
1.06
0.56
4.7
4.3
22.50
21.54
%
0.85
284
2796
743
7706
0.95
0.55
3.4
3.2
36.55
76.99
e6/l
1.60
550
5912
19
142
1.34
0.54
2.7
1.8
—
—
—
0
0
19
142
1.34
0.54
2.7
1.8
—
—
—
0
0
12
82
1.47
0.54
1.0
1.1
—
—
—
0
0
14
99
1.42
0.54
1.3
1.1
139.81
191.31
iu/ml
0.55
14
99
45
377
1.20
0.53
1.5
1.3
0.78
0.65
nmol/l
0.62
40
360
108
968
1.12
0.53
3.6
4.0
24.96
24.92
mmol/l
0.05
101
901
6
39
1.54
0.53
1.2
1.2
29.95
42.47
mg/l
—
6
34
30
371
0.81
0.53
1.4
1.6
—
—
—
0
0
56
652
0.86
0.52
3.9
3.3
25.14
25.01
mmol/l
0.08
56
640
869
8966
0.96
0.52
3.9
3.7
118.38
109.90
e6/l
0.07
589
6355
205
2209
0.92
0.52
3.0
2.9
165.71
198.61
ng/l
0.62
181
2019
207
1920
1.08
0.51
3.1
2.9
10.15
10.56
g/l
0.86
185
1764
350
3698
0.94
0.51
2.6
2.6
2.34
2.31
g/l
0.29
334
3430
24
303
0.79
0.51
1.4
1.7
—
—
—
0
0
85
755
1.13
0.49
1.7
1.7
—
—
—
0
0
29
356
0.81
0.49
1.1
1.5
—
—
—
0
0
11
155
0.71
0.48
1.2
1.7
—
—
—
0
0
28
343
0.81
0.47
1.1
1.1
—
—
—
0
0
24
299
0.80
0.46
1.0
1.1
—
—
—
0
0
62
542
1.15
0.46
1.5
1.4
23.44
30.90
e6/l
0.19
50
409
279
2956
0.94
0.46
7.6
7.4
0.95
1.15
mmol/l
0.41
227
2344
10
142
0.70
0.46
1.0
1.2
—
—
—
0
0
17
221
0.77
0.46
1.2
1.7
—
—
—
0
0
13
176
0.74
0.46
2.3
2.0
—
—
—
0
0
62
543
1.14
0.45
1.6
1.4
394.63
950.63
e6/l
0.85
51
434
136
1480
0.92
0.45
1.5
1.5
—
—
—
0
0
7
50
1.40
0.45
1.0
1.1
—
—
—
0
0
72
638
1.13
0.45
1.5
1.3
—
—
—
0
0
929
9044
1.04
0.44
3.2
3.5
2.37
2.36
mmol/l
1.80
801
7930
80
716
1.12
0.43
1.4
1.6
0.22
0.24
g/l
1.13
73
680
25
306
0.82
0.42
1.5
1.5
—
—
—
0
0
281
2966
0.94
0.42
7.5
7.4
5.10
5.10
kpa
0.01
272
2836
107
1173
0.91
0.42
3.6
2.6
0.62
0.65
%
0.65
107
1165
281
2965
0.94
0.42
7.5
7.4
13.23
12.32
kpa
1.46
272
2836
20
158
1.27
0.41
1.5
1.3
1.52
1.61
g/l
0.74
20
158
48
552
0.87
0.41
1.4
1.3
—
—
—
0
0
48
552
0.87
0.41
1.4
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
14.1
—
—
—
0
0
424
4066
1.05
0.41
1.4
1.4
—
—
—
0
0
50
572
0.87
0.40
1.4
1.5
—
—
—
0
0
1704
16792
1.03
0.40
4.6
4.6
3000.20
2072.64
e6/l
—
10
242
110
1200
0.91
0.40
3.6
2.6
1.08
1.18
%
0.95
110
1190
70
626
1.12
0.39
1.1
1.1
—
—
—
0
0
50
569
0.88
0.38
7.8
8.6
106.02
105.09
mmol/l
0.59
44
509
333
3485
0.95
0.38
2.7
2.7
22.33
22.68
%
0.19
295
2981
38
441
0.86
0.38
2.2
1.6
—
—
—
0
0
38
441
0.86
0.38
2.2
1.6
—
—
—
0
0
12
89
1.35
0.38
1.9
1.5
—
1635592.86
iu/ml
—
0
7
231
2441
0.94
0.37
8.3
8.3
120.41
120.86
g/l
0.13
225
2375
426
4097
1.05
0.37
3.2
3.1
0.78
0.75
ug/l
0.27
275
2763
19
152
1.25
0.37
2.6
2.3
395.95
514.85
e6/l
0.72
19
130
16
125
1.28
0.37
1.0
1.0
—
—
—
0
0
164
1537
1.07
0.35
1.8
2.0
1.10
1.42
g/l
2.86
149
1403
45
512
0.88
0.35
6.5
5.7
499.43
623.60
iu/ml
—
7
77
34
292
1.17
0.34
1.8
1.3
277.72
276.67
mosm/kgh2o
0.09
29
225
10
73
1.37
0.34
2.0
2.3
0.80
1.25
ug/l
—
10
68
812
8315
0.97
0.34
3.4
3.2
31.87
36.98
u/l
1.36
774
7889
80
876
0.91
0.33
2.1
2.7
—
—
—
0
0
1146
11251
1.03
0.33
4.5
4.9
35.76
35.28
g/l
2.41
1056
10478
120
1290
0.93
0.33
2.9
2.8
0.21
0.32
e6/l
0.97
113
1250
12
155
0.77
0.33
1.2
1.7
—
—
—
0
0
52
463
1.13
0.33
1.3
1.2
—
—
—
0
0
13
166
0.78
0.33
2.1
1.7
—
—
—
0
0
14
177
0.79
0.33
1.4
1.6
79.86
84.12
umol/l
0.36
14
177
6
87
0.69
0.33
1.8
1.7
—
—
—
0
0
18
146
1.23
0.32
1.1
1.1
—
—
—
0
0
175
1652
1.06
0.32
1.8
1.8
—
—
—
0
0
34
391
0.87
0.32
1.1
1.1
2.50
1501.78
iu/ml
—
6
87
7
96
0.73
0.30
1.1
2.4
—
31436.94
—
0
16
46
516
0.89
0.30
1.5
1.5
—
—
—
0
0
18
147
1.23
0.30
2.8
2.4
0.19
0.20
e9/l
0.15
18
129
25
293
0.85
0.30
1.5
1.4
—
—
—
0
0
25
293
0.85
0.30
1.5
1.4
—
—
—
0
0
17
207
0.82
0.30
2.2
1.1
—
—
—
0
0
38
430
0.88
0.29
3.7
3.6
2.82
1.45
%
0.67
33
378
25
292
0.85
0.29
1.5
1.4
—
—
—
0
0
25
292
0.85
0.29
1.5
1.4
—
—
—
0
0
252
2631
0.95
0.29
7.7
7.8
95.42
95.62
%
0.13
243
2544
43
383
1.12
0.28
1.5
1.3
0.47
0.40
nmol/l
—
7
23
1257
12384
1.03
0.28
5.1
5.1
0.00
0.00
estimate
0.50
209
2294
144
1525
0.94
0.28
1.8
1.6
—
—
—
0
0
1460
14788
0.98
0.28
8.8
9.3
4.02
4.07
e9/l
0.38
1256
12905
8
62
1.29
0.28
1.0
1.8
—
—
—
0
0
21
248
0.85
0.28
1.5
1.4
24.75
32.20
%
0.35
14
148
34
386
0.88
0.28
1.3
1.1
—
—
—
0
0
51
460
1.11
0.28
1.3
1.2
—
—
—
0
0
8
63
1.27
0.27
1.8
1.5
—
—
—
0
0
19
159
1.20
0.26
2.6
2.0
19.37
17.79
nmol/l
0.37
19
147
81
750
1.08
0.26
1.6
1.9
—
—
—
0
0
181
1900
0.95
0.26
1.7
1.7
—
—
—
0
0
68
625
1.09
0.26
1.7
1.7
9478.84
13378.66
e6/l
0.64
50
450
19
225
0.84
0.26
1.9
2.1
1.23
2.01
u/field
0.72
13
88
22
257
0.85
0.26
2.4
2.3
—
—
—
0
0
5
71
0.70
0.26
1.2
1.1
—
—
—
0
0
216
2068
1.05
0.26
3.7
3.9
93.80
90.95
ng/l
0.14
182
1776
1520
15023
1.02
0.26
4.5
4.7
6.75
6.72
mmol/l
0.18
1419
14077
5
73
0.68
0.26
1.2
1.1
—
—
—
0
0
1271
12536
1.02
0.26
3.7
3.8
0.00
0.00
estimate
1.06
205
2240
16
132
1.21
0.25
1.1
1.1
—
—
—
0
0
11
138
0.80
0.25
1.1
1.6
—
—
—
0
0
11
138
0.80
0.25
1.1
1.6
—
—
—
0
0
41
368
1.12
0.25
1.2
1.2
2.88
5.09
u/ml
1.04
17
152
9
75
1.20
0.25
1.9
1.4
9.61
9.34
ug/l
—
9
75
285
2952
0.96
0.24
4.4
4.3
234.61
250.22
u/l
1.60
271
2795
12
96
1.25
0.24
1.0
1.0
—
—
—
0
0
280
2702
1.04
0.24
1.6
1.8
1.39
1.48
%
1.29
245
2354
81
869
0.93
0.24
4.5
3.7
46.46
70.53
mg/l
0.63
69
704
168
1603
1.05
0.24
2.9
3.4
4.44
4.44
pmol/l
0.01
144
1422
6
85
0.71
0.24
1.0
1.1
—
—
—
0
0
822
8074
1.02
0.23
3.1
3.1
7.36
7.22
mmol/l
0.40
683
6789
101
1074
0.94
0.23
1.8
1.8
40.57
39.18
u/l
0.27
88
952
14
115
1.22
0.23
2.7
4.3
—
—
—
0
0
10
125
0.80
0.23
1.2
2.3
102.90
96.41
%
—
10
116
5
39
1.28
0.23
1.2
1.2
—
—
—
0
0
792
8061
0.98
0.23
2.4
2.6
58.24
69.25
u/l
0.56
727
7444
16
134
1.20
0.22
1.4
1.5
162.43
161.59
pmol/l
0.01
16
134
70
753
0.93
0.22
2.1
1.8
—
—
—
0
0
7
95
0.74
0.22
1.0
1.1
734.29
1637.44
miu/ml
—
7
95
84
787
1.07
0.22
1.3
1.4
308.23
272.19
ug/g
0.83
48
448
5
41
1.22
0.22
1.2
1.1
—
—
—
0
0
79
739
1.07
0.21
1.4
1.6
1.15
1.17
g/l
0.40
73
704
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
2.55
—
0
11
22
251
0.88
0.20
2.7
2.9
—
—
—
0
0
10
123
0.81
0.20
2.3
2.6
850.50
1199.24
u/ml
—
10
123
960
9735
0.98
0.20
3.7
3.6
42.92
101.44
ng/l
0.66
671
6799
0
14
0.00
0.20
0.0
1.1
—
7.75
—
0
14
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
226
2338
0.96
0.20
2.4
2.2
349.59
370.30
nmol/l
0.95
208
2143
54
500
1.08
0.19
1.6
1.9
4.87
4.97
mmol/24h
0.07
42
425
397
3875
1.03
0.19
1.9
2.1
29.75
29.83
s
0.10
388
3766
23
260
0.88
0.19
4.3
4.0
—
—
—
0
0
51
551
0.92
0.19
2.5
2.6
16.89
15.97
%
0.83
27
287
82
869
0.94
0.19
4.5
3.7
39.17
123.62
mg/l
0.70
70
705
36
328
1.10
0.18
1.4
1.5
51.88
58.71
%
0.39
25
205
80
845
0.95
0.17
4.0
3.6
12.57
1.32
ratio
—
7
63
251
2439
1.03
0.17
2.1
2.3
36.34
59.01
u/l
0.59
223
2097
7
63
1.11
0.17
1.0
1.7
—
—
—
0
0
5
66
0.76
0.17
1.0
1.1
—
—
—
0
0
215
2217
0.97
0.17
2.1
2.9
66.37
66.46
g/l
0.07
189
2030
153
1474
1.04
0.16
1.7
1.7
—
—
—
0
0
64
602
1.06
0.16
1.5
1.4
—
—
—
0
0
70
741
0.94
0.16
1.3
2.5
0.00
0.00
g/l
-0.00
62
685
35
321
1.09
0.16
1.0
1.1
0.78
3.48
u/ml
2.99
17
147
394
4023
0.98
0.16
2.5
2.6
13.49
12.98
umol/l
0.76
378
3754
698
7082
0.98
0.16
3.2
3.1
0.31
0.47
e6/l
1.20
516
5394
8
71
1.13
0.16
1.3
1.1
—
—
—
0
0
11
92
1.20
0.16
1.0
1.7
16.30
16.09
pmol/l
0.03
11
78
148
1427
1.04
0.16
2.5
2.2
12.37
12.54
nmol/l
0.08
132
1258
618
6276
0.98
0.16
2.2
2.3
—
—
—
0
0
936
9469
0.98
0.16
3.9
4.0
—
—
—
0
0
6
78
0.77
0.15
1.2
1.1
—
—
—
0
0
6
79
0.76
0.15
1.2
1.1
—
—
—
0
0
113
1177
0.96
0.15
1.6
1.8
1.67
1.57
g/l
0.49
99
1013
20
178
1.12
0.15
2.1
2.0
14.05
15.60
%
0.54
20
170
413
4052
1.02
0.15
2.9
2.9
3.45
2.87
e6/l
0.31
221
2200
51
478
1.07
0.15
1.4
1.4
—
15.81
—
0
9
427
4349
0.98
0.14
2.8
2.7
1.94
1.16
e6/l
0.41
240
2483
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
16
141
1.14
0.14
1.1
1.1
—
—
—
0
0
1309
12987
1.01
0.13
5.8
6.0
1.90
1.92
e9/l
0.27
1153
11459
1324
13137
1.01
0.13
6.0
6.1
0.19
0.19
e9/l
0.03
1152
11496
25
228
1.10
0.13
1.6
1.5
—
—
—
0
0
70
734
0.95
0.13
1.3
2.5
0.00
0.00
g/l
-0.00
62
684
18
161
1.12
0.13
1.4
1.2
—
—
—
0
0
158
1627
0.97
0.13
9.1
8.8
0.65
0.68
%
0.37
158
1615
292
2861
1.02
0.12
3.8
4.1
20.96
22.89
ug/l
0.06
248
2325
34
316
1.08
0.12
1.2
1.1
1.37
3.43
u/ml
1.79
13
134
88
845
1.04
0.12
1.4
1.6
—
371.22
—
0
41
32
344
0.93
0.12
1.5
1.6
—
—
—
0
0
13
114
1.14
0.11
1.0
1.3
152.00
155.95
mmol/24h
0.07
13
114
86
894
0.96
0.11
2.2
2.2
228.36
749.77
ug/l
1.51
75
840
16
178
0.90
0.11
1.2
1.3
0.41
1.07
u/ml
0.53
11
98
26
281
0.92
0.11
1.4
1.5
0.27
0.32
nmol/l
0.25
19
204
58
553
1.05
0.11
2.7
3.1
1.80
1.54
mmol/l
0.33
58
537
163
1589
1.03
0.11
3.8
3.8
5.14
5.18
kpa
0.33
152
1517
31
289
1.07
0.11
1.0
1.1
0.70
1.33
u/ml
0.72
14
139
15
134
1.12
0.11
1.0
1.4
21.07
22.80
umol/l
0.08
15
126
18
163
1.10
0.10
1.4
1.2
—
—
—
0
0
68
652
1.04
0.10
1.1
1.1
12.30
6.27
u/ml
—
7
73
160
1640
0.97
0.10
8.9
8.7
1.21
1.34
%
1.32
160
1631
11
96
1.15
0.10
1.9
2.0
20.46
17.91
ug/l
0.19
11
85
300
2951
1.02
0.10
2.6
2.7
7.15
7.88
umol/l
0.25
256
2568
5
44
1.14
0.10
1.0
1.5
68.00
117.60
ng/l
—
5
44
102
989
1.03
0.09
1.9
2.6
2.96
2.94
g/l
0.09
86
896
50
524
0.95
0.09
1.7
1.7
—
—
—
0
0
23
248
0.93
0.09
6.0
4.9
639.84
61.74
u/ml
—
8
72
71
684
1.04
0.09
1.8
1.7
—
—
—
0
0
17
186
0.91
0.09
1.0
1.0
553.40
316.85
ng/l
—
10
120
21
227
0.92
0.09
1.0
1.0
—
—
—
0
0
108
1050
1.03
0.09
1.8
2.5
3.56
3.64
g/l
0.27
92
957
44
419
1.05
0.09
1.4
1.4
115.50
121.11
u/ml
—
10
79
25
233
1.07
0.09
1.0
1.1
0.85
3.00
u/ml
1.56
11
87
548
5536
0.99
0.09
1.7
1.8
1.60
1.22
mg/l
0.49
412
4274
40
380
1.05
0.09
1.2
1.2
1.47
3.67
u/ml
1.39
17
123
83
857
0.97
0.09
1.3
1.4
—
—
—
0
0
108
1051
1.03
0.08
1.8
2.5
7.52
7.38
g/l
0.33
92
957
108
1051
1.03
0.08
1.8
2.5
—
—
—
0
0
105
1079
0.97
0.08
2.4
1.9
—
—
—
0
0
93
903
1.03
0.08
1.8
2.6
0.42
1.04
g/l
1.46
75
789
502
4968
1.01
0.08
3.3
3.6
290.53
412.30
ng/l
0.69
383
3924
41
430
0.95
0.08
1.2
1.3
40.94
39.14
u/l
0.04
31
369
101
983
1.03
0.08
2.0
1.8
—
—
—
0
0
228
2317
0.98
0.08
4.1
3.8
1.98
1.97
mmol/l
0.00
191
1972
21
195
1.08
0.08
1.6
1.5
0.95
0.98
g/l
0.15
21
195
33
348
0.95
0.08
1.6
1.4
—
—
—
0
0
47
490
0.96
0.07
1.1
1.2
—
273.33
—
0
12
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
6
70
0.86
0.07
1.2
1.1
114.33
104.44
%
—
6
62
6
73
0.82
0.07
1.2
1.1
—
—
—
0
0
6
75
0.80
0.07
2.2
1.7
—
—
—
0
0
46
479
0.96
0.07
1.9
1.7
—
—
—
0
0
7
80
0.87
0.07
2.7
2.2
20.29
29.07
%
—
7
72
7
80
0.87
0.07
1.6
2.4
124.71
179.26
%
—
7
72
269
2726
0.99
0.07
3.0
3.5
—
—
—
0
0
21
196
1.07
0.07
1.2
1.1
—
—
—
0
0
17
157
1.08
0.07
1.0
1.0
—
—
—
0
0
49
472
1.04
0.06
1.6
1.9
520.88
2430.37
u/l
2.11
20
185
9
101
0.89
0.06
1.2
1.4
—
—
—
0
0
26
246
1.06
0.06
1.1
1.1
0.73
2.37
u/ml
2.28
12
107
330
3267
1.01
0.06
6.8
7.0
—
—
—
0
0
54
523
1.03
0.06
2.9
3.8
56.43
57.36
%
0.24
54
523
1244
12394
1.01
0.05
3.7
3.8
0.00
0.00
estimate
1.23
219
2464
28
267
1.05
0.05
2.4
1.7
—
—
—
0
0
29
277
1.05
0.05
1.0
1.1
—
—
—
0
0
46
475
0.97
0.05
1.5
1.3
12.69
12.23
u/l
0.08
35
378
72
703
1.02
0.05
1.2
1.2
—
—
—
0
0
153
1508
1.02
0.05
3.7
3.7
1.41
1.91
mmol/l
1.12
118
1144
77
753
1.02
0.05
1.3
1.3
—
—
—
0
0
11
120
0.92
0.05
2.4
2.4
—
—
—
0
0
17
181
0.94
0.05
1.4
1.4
—
—
—
0
0
81
827
0.98
0.04
1.3
2.4
38.41
37.76
g/l
0.43
65
732
14
130
1.08
0.04
2.2
3.6
—
—
—
0
0
25
239
1.05
0.04
2.4
1.6
—
—
—
0
0
25
239
1.05
0.04
2.4
1.6
—
—
—
0
0
25
239
1.05
0.04
2.4
1.6
—
—
—
0
0
821
8177
1.01
0.04
3.7
3.8
7.65
9.08
mg/mmol
0.31
487
5049
35
362
0.97
0.04
1.2
1.4
—
—
—
0
0
21
200
1.05
0.03
1.2
1.2
68.00
122.00
titre
—
5
40
561
5633
0.99
0.03
1.6
1.7
48222644.50
33441018.98
pmol/l
0.21
450
4662
61
599
1.02
0.02
1.9
1.7
301.93
314.08
mu/l
0.14
55
543
1359
13565
1.00
0.02
6.1
6.4
11.24
11.26
umol/l
0.02
1289
12899
87
882
0.99
0.02
1.7
1.7
—
—
—
0
0
99
978
1.01
0.02
1.8
2.5
9.96
10.32
g/l
0.44
81
879
104
1028
1.01
0.02
5.3
6.0
0.86
0.89
%
0.42
98
962
36
369
0.98
0.02
1.2
1.1
—
—
—
0
0
18
188
0.96
0.02
1.0
1.0
61.91
45.43
ng/l
0.58
11
118
44
431
1.02
0.02
1.3
1.2
285.82
273.91
u/ml
0.12
31
261
11
103
1.07
0.02
1.1
1.3
—
—
—
0
0
103
1040
0.99
0.02
5.3
6.0
1.44
1.59
%
1.18
97
972
429
4276
1.00
0.01
3.5
3.4
0.82
0.81
mmol/l
0.44
404
4008
151
1520
0.99
0.01
1.3
1.3
164.66
202.67
u/ml
0.54
138
1394
53
522
1.02
0.01
2.8
3.2
7.29
7.52
mmol/l
0.27
53
509
138
1371
1.01
0.01
9.3
10.5
—
—
—
0
0
98
973
1.01
0.01
3.8
3.5
32.21
4419.01
u/ml
0.90
86
824
777
7761
1.00
0.00
3.2
3.2
359.90
321.52
mg/l
0.09
469
4833
18
186
0.97
0.00
1.0
1.0
496.50
722.37
ng/l
—
10
118
20
194
1.03
0.00
1.0
1.3
—
—
—
0
0
25
256
0.98
0.00
1.4
1.5
—
—
—
0
0
492
4927
1.00
0.00
3.1
3.1
2.47
2.46
mmol/l
0.94
434
4323
11
115
0.96
0.00
8.8
11.2
0.53
0.63
mmol/l
0.72
11
107
25
255
0.98
0.00
1.4
1.3
—
—
—
0
0
29
285
1.02
0.00
2.3
1.7
—
—
—
0
0
17
171
0.99
0.00
1.2
1.1
31.42
43.39
mg/l
0.97
12
146
75
751
1.00
0.00
1.6
1.5
0.04
8.95
iu/ml
0.58
14
152
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
10
104
0.96
0.00
1.4
2.3
122.60
160.16
%
—
10
96
231
2305
1.00
0.00
6.5
7.8
8.80
10.06
mmol/l
2.12
223
2207
22
224
0.98
0.00
1.1
1.3
—
—
—
0
0
24
236
1.02
0.00
2.3
1.6
—
—
—
0
0
29
292
0.99
0.00
1.1
1.3
7.56
7.47
mmol/l
0.05
24
253
31
312
0.99
0.00
1.7
1.8
19.45
24.09
ug/l
0.45
31
306
35
348
1.01
0.00
1.1
1.1
—
—
—
0
0
37
368
1.01
0.00
1.1
1.1
0.30
1.98
u/ml
3.06
17
179
56
562
1.00
0.00
2.0
2.3
132.92
128.39
g/l
0.63
36
411
79
792
1.00
0.00
1.4
2.5
0.01
0.02
g/l
0.27
71
732
751
7507
1.00
0.00
2.9
3.0
1482.66
1406.56
ng/l
0.10
621
6455
11
113
0.97
0.00
1.2
1.1
—
11.23
u/ml
—
0
13
22
223
0.99
0.00
1.1
1.1
—
—
—
0
0
22
223
0.99
0.00
2.8
1.9
2.85
4.29
mg/l
2.12
22
217
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.0
1.3
—
—
—
0
0
11
110
1.00
-0.00
1.3
1.2
—
—
—
0
0
7
72
0.97
-0.00
1.7
2.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.17
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
2.07
—
0
8
7
72
0.97
-0.00
1.7
2.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.0
1.1
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
1.27
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
8
85
0.94
-0.00
1.1
1.3
3.88
3.91
umol/l
—
8
79
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_OTOSCLE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTOSCLE | 0.764 [0.69, 0.85] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.047 |
During the follow-up period (1.1.1998 — 31.12.2019), 728 out of 7721 females with H8_OTOSCLE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_OTOSCLE | 0.687 [0.62, 0.76] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.07 |
During the follow-up period (1.1.1998 — 31.12.2019), 547 out of 4710 males with H8_OTOSCLE died.
Mortality risk
Mortality risk for people of age
years, who have H8_OTOSCLE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.069% | 0.179% |
| 5 | 0.418% | 0.94% |
| 10 | 1.008% | 2.26% |
| 15 | 1.966% | 4.465% |
| 20 | 3.456% | 7.889% |
Relationships between endpoints
↥Index endpoint: H8_OTOSCLE – Otosclerosis
GWS hits: 41
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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