Alzheimer’s disease, wide definition

G6_AD_WIDE

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 F00*, G30
  • Hospital discharge: ICD-9 3310
  • Hospital discharge: ICD-8 29010
  • Cause of death: ICD-10 F00*, G30
  • Cause of death: ICD-9 3310
  • Cause of death: ICD-8 29010
  • KELA reimbursements: KELA codes 307
  • KELA reimbursements: ICD-10 F00*, G30
  • Medicine purchases: ATC N06D

4 out of 7 registries used, show all original rules.

17523

4. Check minimum number of events

Min. number of events 3
17523

5. Include endpoints

17523

6. Filter based on genotype QC (FinnGen only)

16902

Control definitions (FinnGen only)

Control exclude
G6_ALZHEIMER

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 296681 184829 109969
Only index persons 255430 161059 94371
Unadjusted period prevalence (%)
Whole population 4.45 5.29 3.07
Only index persons 5.06 5.92 3.60
Median age at first event (years)
Whole population 80.87 81.69 79.54
Only index persons 81.07 81.88 79.69

-FinnGen-

Key figures

All Female Male
Number of individuals 16902 7607 9295
Unadjusted period prevalence (%) 3.91 2.99 4.67
Median age at first event (years) 79.10 79.21 79.01

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
8931
Matched controls
74235
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
8.4
323.0
2552
3373
P20
ICPC
Memory disturbance
11.8
323.0
4624
6194
G30.8
ICD-10 Finland
Other Alzheimer disease
217.4
323.0
1122
49
N05AH04
ATC
quetiapine; oral
4.6
323.0
1897
4094
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
1567.2
323.0
348
*
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
95.9
323.0
922
89
P70
ICPC
Dementia
50.1
323.0
882
162
SPAT1053
SPAT
Memory test
5.4
323.0
4152
10280
F00.10
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
766.5
323.0
761
9
F06.7
ICD-10 Finland
Mild cognitive disorder
9.5
323.0
880
847
F00.20
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
417.3
323.0
432
9
N06DA03
ATC
rivastigmine; oral, transdermal
356.9
323.0
2701
90
SPAT1216
SPAT
Assessment of functional ability
3.2
323.0
2681
8761
N06DX01
ATC
memantine; oral
623.2
323.0
4614
127
G30
ICD-10 Finland
Alzheimer disease
216.1
323.0
561
23
G30.0
ICD-10 Finland
Alzheimer disease with early onset
1138.7
323.0
637
5
G30.1
ICD-10 Finland
Alzheimer disease with late onset
254.5
323.0
3837
219
N06DA02
ATC
donepezil; oral
414.5
323.0
4356
170
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.6
323.0
1646
3487
A28
ICPC
Limited function/disability NOS
3.6
323.0
2846
8468
F03
ICD-10 Finland
Unspecified dementia
12.4
323.0
1466
1161
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
1987.0
323.0
2115
12
N05AX08
ATC
risperidone; systemic
10.9
323.0
1840
1722
SPAT1245
SPAT
Provision of support and information to patient’s family members
7.0
323.0
1173
1558
N06DA04
ATC
galantamine; oral
303.9
323.0
1251
40
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
814.6
323.0
1805
23
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
231.4
323.0
1713
76
SPAT1234
SPAT
Support of social functional capacity
5.3
303.2
1031
1769
R41.3
ICD-10 Finland
Other amnesia
7.4
298.4
780
944
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.4
269.4
1111
2328
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
249.4
2216
8228
TAB00
NOMESCO Finland
Lumbar puncture
5.9
224.4
692
1041
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
207.5
219.8
243
10
R53
ICD-10 Finland
Malaise and fatigue
2.4
217.3
2316
9387
AA1AD
NOMESCO Finland
CT of head and brain
2.2
203.5
2988
14031
SPAT1254
SPAT
Administration of medicine
2.5
194.5
1850
7001
F0019, G301
ICD-10 Finland
NA
+∞
187.8
193
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
4.1
169.4
732
1573
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
169.3
3148
15994
L28
ICPC
Limited function/disability (L)
2.2
165.2
2047
8745
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
158.6
2078
9081
N06AX11
ATC
mirtazapine; oral
2.0
153.8
2830
14192
R41.0
ICD-10 Finland
Disorientation, unspecified
4.8
147.8
546
1001
N05BA04
ATC
oxazepam; oral
2.0
137.1
2315
11131
F05.1
ICD-10 Finland
Delirium superimposed on dementia
30.1
136.4
195
55
F00.00
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
602.6
135.1
143
*
WYA20
NOMESCO Finland
Home visit
8.9
134.7
309
297
G20
ICD-10 Finland
Parkinson disease
3.8
133.8
624
1428
XA800
NOMESCO Finland
Neuropsychological investigation
4.8
132.6
486
882
F009, G309
ICD-10 Finland
NA
+∞
127.3
131
*
110
Kela drug reimbursment
Parkinson's disease and comparable movement disrorders
3.9
126.5
572
1272
F02.39*G20
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
19.0
126.2
206
92
N06AB10
ATC
escitalopram; oral
2.3
125.2
1331
5207
N03AG01
ATC
valproic acid; systemic, rectal
3.7
122.5
590
1385
N06AX26
ATC
vortioxetine; oral
4.6
121.2
460
865
A04
ICPC
Weakness/tiredness general
2.2
117.2
1387
5694
SPAT1101
SPAT
Orthostatic test
3.1
116.6
730
2091
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.1
114.8
1508
6478
SPAT1229
SPAT
Assessment of need for aid
2.4
108.0
1081
4078
SPAT1304
SPAT
Counselling and guidance related to ageing
2.3
105.8
1115
4316
N87
ICPC
Parkinsonism
5.7
104.3
323
482
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
104.2
847
2852
SPAT1252
SPAT
Overall medication plan or its review
2.4
100.1
932
3379
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
21.5
99.0
155
61
N05AH03
ATC
olanzapine; systemic
3.8
97.2
459
1056
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.0
97.1
1375
6053
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
5.5
95.8
309
484
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.7
95.5
712
2275
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
6.8
94.2
255
318
SPAT1360
SPAT
Extensive global examination
2.3
93.2
934
3513
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.7
93.1
700
2247
SPAT1301
SPAT
No procedures
1.6
92.6
3199
18844
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
86.3
2557
14370
A29
ICPC
General symptom/complaint other
2.0
84.5
1175
5109
U04
ICPC
Incontinence urine
2.7
82.7
615
1956
F0009, G300
ICD-10 Finland
NA
+∞
81.5
84
*
N04BA03
ATC
levodopa, decarboxylase inhibitor and COMT inhibitor; oral
6.6
81.0
225
291
A06AD11
ATC
lactulose; oral
1.8
79.4
1635
8195
SPAT1172
SPAT
Guidance concerning hydration
3.9
78.6
352
772
F00
ICD-10 Finland
Dementia in Alzheimer disease
33.3
77.0
107
27
SPAT1246
SPAT
Screening of depression or other psychiatric problem
4.3
75.8
307
614
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.7
75.7
1748
9068
F00.14
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms of mixed type
652.7
73.9
78
*
AXX01
SPAT
NA
4.8
73.7
264
466
F01.20
ICD-10 Finland
Subcortical vascular dementia without additional symptoms
9.8
72.9
157
135
I95.1
ICD-10 Finland
Orthostatic hypotension
2.8
72.4
504
1538
F05.9
ICD-10 Finland
Delirium, unspecified
4.2
71.7
292
587
N05BA06
ATC
lorazepam; systemic, sublingual
2.6
71.6
565
1858
S01.0
ICD-10 Finland
Open wound of scalp
2.3
70.8
761
2942
R55
ICD-10 Finland
Syncope and collapse
1.9
70.1
1213
5702
Z02.4
ICD-10 Finland
Examination for driving licence
0.6
68.7
1620
19642
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.0
65.6
912
3941
130
Kela drug reimbursment
Malignant tumour
0.4
62.8
221
4842
N05AD01
ATC
haloperidol; systemic
3.2
61.9
357
958
F001, G301
ICD-10 Finland
NA
+∞
60.2
62
*
N02BE01
ATC
paracetamol; systemic, rectal
1.6
60.0
7385
55689
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
1.9
60.0
975
4463
N04BD01
ATC
selegiline; oral
4.2
59.6
244
493
F21
ICPC
NA
7.5
59.3
149
167
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
59.3
1299
6574
F01.9
ICD-10 Finland
Vascular dementia, unspecified
4.6
58.9
220
406
S06.0
ICD-10 Finland
Concussion
2.0
58.6
847
3706
N06AB04
ATC
citalopram; systemic
1.6
58.3
1672
9142
Z75.5
ICD-10 Finland
Holiday relief care
6.6
57.3
157
200
H02AB02
ATC
dexamethasone; systemic
0.4
56.8
251
5024
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.1
56.7
729
3040
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.0
56.3
354
1009
F02.39
ICD-10 Finland
Dementia in Parkinson's disease without information on additional symptoms
35.3
55.7
76
18
S72.0
ICD-10 Finland
Fracture of neck of femur
2.5
55.6
473
1619
R41
ICD-10 Finland
Other symptoms and signs involving cognitive functions and awareness
7.2
55.3
143
168
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
3.3
54.8
302
784
SPAT1139
SPAT
Nutrition survey
3.0
53.5
343
991
R42
ICD-10 Finland
Dizziness and giddiness
1.5
53.0
2114
12503
F00.19
ICD-10 Finland
Dementia in Alzheimer's disease with late onset without information about additional symptoms
100.4
51.5
60
5
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
50.9
1293
6810
SPAT1231
SPAT
Assessment of adjustments needed in living environment
3.2
50.8
285
748
SPAT1167
SPAT
Insertion of urinary catheter
2.5
50.5
433
1489
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
4.1
50.4
208
424
F0014, G301
ICD-10 Finland
NA
+∞
50.4
52
*
Z02.7
ICD-10 Finland
Issue of medical certificate
2.2
50.1
543
2099
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.9
49.7
327
961
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
49.3
655
2765
G31.0
ICD-10 Finland
Circumscribed brain atrophy
8.5
48.3
112
111
F00.1
ICD-10 Finland
Dementia in Alzheimer disease with late onset
424.8
47.8
51
*
G04BD12
ATC
mirabegron; oral
1.7
47.5
1178
6149
F01.2
ICD-10 Finland
Subcortical vascular dementia
10.4
46.9
97
78
N04BD02
ATC
rasagiline; oral
5.4
45.7
145
224
W19
ICD-10 Finland
Unspecified fall
1.8
45.3
803
3772
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
44.4
2847
18434
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.1
42.9
516
2088
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.2
42.7
448
1702
SPAT1050
SPAT
Extensive neurological examination
3.0
42.5
264
746
N29
ICPC
Neurological sympt/complt other
3.3
42.0
227
582
F0029, G308
ICD-10 Finland
NA
+∞
40.7
42
*
N28
ICPC
Limited function/disability (N)
3.5
40.5
205
500
N27
ICPC
Fear of neurological disease other
3.6
40.4
196
462
N06AB06
ATC
sertraline; oral
1.9
39.7
624
2803
C10AA01
ATC
simvastatin; oral
1.3
38.9
4664
33279
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.8
38.4
676
3162
SPAT1263
SPAT
Sampling
1.4
38.1
3518
24061
193
Kela drug reimbursment
Rasagiline
5.6
37.8
116
173
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.4
37.7
2670
17467
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
26.5
37.2
54
17
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.9
37.0
577
2584
SPAT1100
SPAT
Long-term monitoring of blood pressure
1.8
36.7
737
3596
S70.0
ICD-10 Finland
Contusion of hip
2.3
35.6
347
1274
A03FA01
ATC
metoclopramide; systemic, rectal
0.6
35.4
864
10635
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
1.7
35.4
732
3602
SPAT1305
SPAT
Counselling and guidance related to physical exercise
1.7
35.2
861
4454
N04BC04
ATC
ropinirole; oral
3.9
35.0
154
335
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.2
34.8
374
1437
F00.24
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type other additional symptoms of mixed type
306.9
34.3
37
*
Z2445
NOMESCO Finland
Psychologist
2.9
34.3
217
623
Z01.9
ICD-10 Finland
Special examination, unspecified
1.9
33.9
498
2181
3310A
ICD-9 Finland
Other cerebral degenerations, Alzheimer's disease
+∞
33.0
34
*
F01.29
ICD-10 Finland
Subcortical vascular dementia without information on additional symptoms
10.2
32.7
68
56
Z29
ICPC
Social problem NOS
3.4
32.2
165
408
WX402
NOMESCO Finland
General anaesthesia
0.6
32.0
500
6806
N05AD03
ATC
melperone; systemic
3.4
32.0
162
397
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
0.3
31.7
73
1939
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.5
31.7
1092
6163
F01.30
ICD-10 Finland
Mixed cortical and subcortical vascular dementia without additional symptoms
8.1
31.1
73
75
F00.11
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms, mainly paranoidism
100.1
31.1
36
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.7
31.0
764
3954
N30.0
ICD-10 Finland
Acute cystitis
1.5
30.8
1088
6168
E86
ICD-10 Finland
Volume depletion
2.6
30.7
243
801
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
0.3
30.2
70
1858
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
2.1
29.2
347
1396
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.5
29.2
1308
7803
A04AA02
ATC
granisetron; systemic, transdermal
0.4
29.1
133
2640
G04CA02
ATC
tamsulosin; oral
1.3
28.9
2549
17112
P29
ICPC
Psychological sympt/compl other
2.5
28.2
237
808
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
2.9
27.7
180
528
F29
ICD-10 Finland
Unspecified nonorganic psychosis
3.2
27.5
155
411
N02AA05
ATC
oxycodone; systemic
1.4
27.5
1344
8149
F0011, G301
ICD-10 Finland
NA
+∞
27.1
28
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.5
26.4
993
5702
T90.5
ICD-10 Finland
Sequelae of intracranial injury
4.0
26.3
109
226
R1250
NOMESCO Finland
Evaluation of functional capability
2.8
26.2
174
515
F00, F03
ICD-10 Finland
NA
+∞
26.2
27
*
L01BC06
ATC
capecitabine; oral
0.3
25.1
62
1594
S72.1
ICD-10 Finland
Pertrochanteric fracture
2.4
25.0
217
754
R23.8
ICD-10 Finland
Other and unspecified skin changes
0.7
25.0
701
8442
SPAT1307
SPAT
Psychosocial counselling and guidance
2.4
24.4
220
778
R33
ICD-10 Finland
Retention of urine
1.5
24.3
827
4636
N04BX02
ATC
entacapone; oral
6.0
24.3
70
98
SPAT1262
SPAT
Handing over of treatment supplies
1.4
24.1
1647
10570
B03BA03
ATC
hydroxocobalamin; parenteral
1.7
24.0
558
2840
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
2.5
23.8
188
621
F02.30
ICD-10 Finland
Dementia in Parkinson's disease without additional symptoms
60.5
23.7
29
*
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.4
23.6
1265
7782
R1250
SPAT
NA
5.2
23.6
76
122
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.4
23.6
1288
7949
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
2.9
23.4
146
418
N07AA05
ATC
NA
+∞
23.3
24
*
L82
ICD-10 Finland
Seborrhoeic keratosis
0.7
23.1
745
8755
A27
ICPC
Fear of other disease NOS
1.9
22.8
378
1729
N99
ICPC
Neurological disease other
3.4
22.7
116
289
SPAT1251
SPAT
Organisation of medication
2.0
22.6
310
1324
F02.09*G31.0
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
13.9
22.5
40
24
F01
ICD-10 Finland
Vascular dementia
6.9
22.5
58
70
SPAT1236
SPAT
Informing family of child’s disability
2.3
22.5
208
746
K90
ICPC
Stroke/cerebrovascular accident
2.0
22.4
292
1223
N06AX21
ATC
duloxetine; oral
1.6
22.3
618
3294
F0024, G308
ICD-10 Finland
NA
+∞
22.3
23
*
F00.01
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms, mainly paranoidism
+∞
22.3
23
*
F00.13
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset other additional symptoms, mainly depression
+∞
22.3
23
*
F00.09
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset information on additional symptoms is lacking
+∞
22.3
23
*
R11
ICD-10 Finland
Nausea and vomiting
1.6
22.2
580
3042
SPAT1215
SPAT
Assessment of need for medical rehabilitation
1.9
22.2
354
1598
SPAT1125
SPAT
Stoma care and guidance
2.6
22.1
173
568
F22.0
ICD-10 Finland
Delusional disorder
3.1
22.1
127
345
N03AE01
ATC
clonazepam; systemic
1.8
22.0
426
2050
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.7
21.9
516
2635
N40
ICD-10 Finland
Hyperplasia of prostate
1.3
21.9
2367
16217
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.6
21.9
668
3651
N02AJ06
ATC
codeine and paracetamol; systemic
0.8
21.6
1799
18350
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
21.5
2483
17146
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
3.1
21.4
125
343
N05AH02
ATC
clozapine; systemic
4.6
21.3
77
141
AA1AD
SPAT
NA
9.1
21.2
46
42
F05.8
ICD-10 Finland
Other delirium
4.0
21.2
87
180
P05
ICPC
Senility, feeling/behaving old
5.3
21.2
67
106
SPAT1260
SPAT
Consultation of another employee
1.3
20.8
1479
9526
WF049
NOMESCO Finland
Radiotherapy of metastasis
0.4
20.8
69
1556
J01EA01
ATC
trimethoprim; systemic
1.3
20.6
1897
12690
N17
ICPC
Vertigo/dizziness
1.4
20.2
964
5792
N04AA02
ATC
biperiden; systemic
2.8
20.2
139
424
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.6
20.1
543
2876
N06AX16
ATC
venlafaxine; oral
1.5
20.0
642
3547
R32
ICD-10 Finland
Unspecified urinary incontinence
2.0
19.9
255
1059
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.3
19.9
2227
15285
F02.32
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly hallucinations
95.8
19.9
23
*
F06.9
ICD-10 Finland
Unspecified mental disorder due to brain damage and dysfunction and to physical disease
7.8
19.9
47
50
F00.12
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset, other additional symptoms, mainly hallucinations
174.9
19.1
21
*
SPAT1276
SPAT
Outlining of treatment with patient or their family members
2.2
19.0
210
820
G04BD08
ATC
solifenacin; oral
1.5
19.0
640
3573
SPAT1284
SPAT
Extensive health certificate
2.2
18.9
197
751
SPAT1281
SPAT
Other administrative function
1.5
18.9
612
3391
WZC30
NOMESCO Finland
Teaching
0.7
18.7
561
6697
N04BC05
ATC
pramipexole; oral
1.5
18.7
622
3461
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
18.7
1012
6215
SPAT1279
SPAT
Preparation of immediate hospitalisation
3.1
18.7
108
295
A04AA01
ATC
ondansetron; systemic, rectal
0.5
18.7
186
2858
R44.1
ICD-10 Finland
Visual hallucinations
4.9
18.6
63
108
Z28
ICPC
Limited function/disability (Z)
4.8
18.5
63
109
F00.2
ICD-10 Finland
Dementia in Alzheimer disease, atypical or mixed type
+∞
18.4
19
*
K59.09
ICD-10 Finland
Constipation, unspecified
1.6
18.4
541
2928
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
2.2
18.3
188
711
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
0.8
18.3
1410
14578
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
2.4
18.3
158
550
F02.80
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere without additional symptoms
47.9
18.2
23
*
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
2.5
18.1
142
470
H02AA02
ATC
fludrocortisone; oral
3.4
17.9
88
214
R63.4
ICD-10 Finland
Abnormal weight loss
1.8
17.9
310
1440
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
0.4
17.7
75
1529
Z13.3
ICD-10 Finland
Special screening examination for mental and behavioural disorders
12.0
17.6
33
23
L89
ICD-10 Finland
Decubitus ulcer and pressure area
2.3
17.4
163
590
N03AX14
ATC
levetiracetam; systemic
2.2
17.4
191
746
G21.9
ICD-10 Finland
Secondary parkinsonism, unspecified
5.0
17.2
57
96
F00.29
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without information on additional symptoms
158.2
17.2
19
*
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
6.8
17.1
44
54
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
2.1
17.0
200
803
K59.0
ICD-10 Finland
Constipation
1.6
17.0
475
2535
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.4
17.0
743
4385
R35
ICD-10 Finland
Polyuria
1.5
16.8
566
3160
R25.1
ICD-10 Finland
Tremor, unspecified
1.9
16.6
250
1107
F06.0
ICD-10 Finland
Organic hallucinosis
8.8
16.5
36
34
F002, G308
ICD-10 Finland
NA
+∞
16.5
17
*
F00.22
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type other additional symptoms, mainly hallucinations
+∞
16.5
17
*
N05AB03
ATC
perphenazine; systemic, rectal
2.0
16.4
220
935
M01AH05
ATC
etoricoxib; oral
0.8
16.3
3025
28490
SPAT1014
SPAT
Treatment of eyes
2.3
16.3
154
563
S00.0
ICD-10 Finland
Superficial injury of scalp
2.2
16.2
163
610
A10AE04
ATC
insulin glargine; parenteral
1.4
16.2
702
4133
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
1.6
16.2
429
2261
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
2.5
16.2
129
431
N18
ICPC
Paralysis/weakness
2.1
15.9
181
720
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
1.7
15.9
351
1760
EBA15
NOMESCO Finland
Extraction of large number of teeth
1.8
15.9
280
1313
XF606
SPAT
NA
6.7
15.8
41
51
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.4
15.7
875
5398
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
2.3
15.7
144
519
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
6.6
15.6
41
52
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
1.9
15.6
247
1114
F00.21
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type of other additional symptoms, mainly paranoidism
+∞
15.5
16
*
F00.04
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms of mixed type
+∞
15.5
16
*
F009, F03
ICD-10 Finland
NA
+∞
15.5
16
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
2.3
15.5
145
527
A69
ICPC
General and Unspecified, Other reason for encounter NEC
2.0
15.5
204
862
JN4BD
NOMESCO Finland
Extensive body CT
0.7
15.4
558
6448
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
1.3
15.4
1042
6636
Z51.88
ICD-10 Finland
Other specified medical care
2.2
15.4
167
649
SPAT1249
SPAT
Treatment-related counselling outside office
1.2
15.3
3055
22242
A01
ICPC
Pain general/multiple sites
1.5
15.2
560
3191
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
0.4
15.2
78
1478
K08.3
ICD-10 Finland
Retained dental root
1.5
15.2
504
2808
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.4
15.0
728
4380
XF606
NOMESCO Finland
Ortostatic test
2.9
14.8
92
266
J01CA08
ATC
pivmecillinam; oral
1.2
14.8
2439
17398
R29.6
ICD-10 Finland
Tendency to fall, not elsewhere classified
4.6
14.8
52
94
N19
ICPC
Speech disorder
2.5
14.8
115
381
NA1AD
NOMESCO Finland
Cervical spine CT examination
1.8
14.6
276
1323
B01AB10
ATC
tinzaparin; parenteral
0.6
14.6
250
3344
G46.8*I67.9
ICD-10 Finland
Other vascular syndromes of brain in cerebrovascular diseases
8.6
14.5
32
31
N04BC09
ATC
rotigotine; transdermal
4.3
14.5
55
108
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
1.4
14.4
734
4454
SPAT1285
SPAT
Provision of consultation response
1.5
14.3
436
2381
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.2
14.3
1901
13235
SPAT1138
SPAT
Guidance concerning bowel function
2.4
14.2
121
421
XX3DW
NOMESCO Finland
Time consuming IT work
0.7
14.2
446
5286
G72.8
ICD-10 Finland
Other specified myopathies
2.3
14.2
128
458
F01.19
ICD-10 Finland
Multi-infarct dementia without information on additional symptoms
6.0
14.0
39
54
WF002
NOMESCO Finland
Radical radiotherapy
0.6
14.0
200
2792
N03AF02
ATC
oxcarbazepine; oral
1.9
13.9
200
876
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
2.4
13.8
114
391
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
0.7
13.6
513
5897
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
0.1
13.6
8
463
S28
ICPC
Limited function/disability (S)
3.9
13.6
56
119
F0023, G308
ICD-10 Finland
NA
+∞
13.6
14
*
Q90.9
ICD-10 Finland
Down syndrome, unspecified
+∞
13.6
14
*
F0024, G301
ICD-10 Finland
NA
+∞
13.6
14
*
F0004, G300
ICD-10 Finland
NA
+∞
13.6
14
*
JN4AD
NOMESCO Finland
Body CT examination
0.7
13.5
340
4196
T08
ICPC
Weight loss
2.3
13.5
123
442
C34.1
ICD-10 Finland
Malignant neoplasm: Upper lobe, bronchus or lung
0.2
13.4
15
581
A04AA55
ATC
palonosetron, combinations; systemic
0.3
13.4
21
674
L57.0
ICD-10 Finland
Actinic keratosis
0.7
13.4
610
6804
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.6
13.3
169
2427
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
8.6
13.3
29
28
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
3.1
13.2
72
192
F01.34
ICD-10 Finland
Mixed cortical and subcortical vascular dementia are other mixed symptoms of mixed type
13.7
13.2
23
14
WX212
NOMESCO Finland
Femoral plexus blockade
2.1
13.1
158
645
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
2.2
13.1
134
509
AA1CG
SPAT
NA
3.9
13.1
54
115
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
4.1
13.1
52
107
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
1.4
13.0
757
4699
SPAT1244
SPAT
Occupational therapy
2.6
12.9
93
296
T05
ICPC
Feeding problem of adult
4.1
12.9
51
105
H02AB06
ATC
prednisolone; systemic
0.8
12.8
2932
27292
F01.24
ICD-10 Finland
Subcortical vascular dementia other additional symptoms of mixed type
9.8
12.8
26
22
F01.23
ICD-10 Finland
Subcortical vascular dementia other additional symptoms, mainly depression
18.5
12.8
20
9
SPAT1127
SPAT
Enema
2.8
12.8
81
239
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
0.4
12.7
40
920
L75
ICPC
Fracture: femur
2.3
12.7
113
404
R03AC02
ATC
salbutamol; inhalant
0.8
12.6
2880
26824
F0022, G308
ICD-10 Finland
NA
+∞
12.6
13
*
F0012, G301
ICD-10 Finland
NA
+∞
12.6
13
*
HA1RA
SPAT
NA
0.2
12.5
15
559
P28
ICPC
Limited function/disability (P)
4.1
12.5
49
100
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
0.6
12.5
148
2166
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
1.9
12.5
172
741
F00.23
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type of other additional symptoms, mainly depression
116.5
12.4
14
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
0.6
12.4
256
3287
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
4.5
12.3
44
82
N05AX12
ATC
aripiprazole; systemic
2.5
12.3
95
314
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
0.8
12.3
2117
20222
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
1.6
12.3
363
1968
ZX120
NOMESCO Finland
Intravenous
0.7
12.3
390
4612
N30.9
ICD-10 Finland
Cystitis, unspecified
1.5
12.3
381
2092
Y94.0
ICD-10 Finland
Accident at home
2.1
12.2
138
551
A23
ICPC
Risk factor NOS
1.6
12.2
293
1508
A11CC03
ATC
alfacalcidol; systemic
0.4
12.1
42
926
SPAT1104
SPAT
Monitoring of emergency patient
1.4
12.1
517
3040
UKC02
NOMESCO Finland
Cystoscopy
1.2
12.1
1559
10797
Z60.8
ICD-10 Finland
Other problems related to social environment
5.6
12.0
35
52
2900A
ICD-9 Finland
Senile and presenile organic psychotic conditions, Senile dementia, uncomplicated
4.9
12.0
39
66
AA1AA
NOMESCO Finland
Head X-ray examination
2.7
12.0
83
259
F01.10
ICD-10 Finland
Multi-infarct dementia without additional symptoms
5.8
12.0
34
49
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
2.4
11.9
102
358
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
11.9
309
1627
G04BD09
ATC
trospium; oral
1.8
11.8
220
1052
E0000UV
ATC
NA
1.2
11.8
2687
19687
Z01.8
ICD-10 Finland
Other specified special examinations
1.2
11.8
1517
10500
A06AC01
ATC
ispaghula (psylla seeds); oral
1.2
11.8
1920
13627
L03AA02
ATC
filgrastim; parenteral
0.4
11.7
53
1053
SPAT1310
SPAT
Counselling related to known health issue
1.2
11.7
2502
18222
-2
ICPC
NA
3.6
11.7
53
123
G91.0
ICD-10 Finland
Communicating hydrocephalus
3.4
11.7
56
136
R00.1
ICD-10 Finland
Bradycardia, unspecified
1.6
11.7
302
1584
NE1AA
NOMESCO Finland
Pelvis X-ray examination
1.4
11.7
551
3301
Z03
ICPC
Housing/neighbourhood problem
3.6
11.6
53
124
G04BD04
ATC
oxybutynin; oral, transdermal
1.5
11.6
464
2691
L03AA13
ATC
pegfilgrastim; parenteral
0.5
11.6
81
1379
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
3.8
11.5
48
104
S06.3
ICD-10 Finland
Focal brain injury
2.3
11.4
105
382
D12
ICPC
Constipation
1.6
11.4
279
1445
W06
ICD-10 Finland
Fall involving bed
2.9
11.3
70
203
X59
ICD-10 Finland
Exposure to unspecified factor
1.3
11.2
1127
7569
G40
ICD-10 Finland
Epilepsy
3.0
11.2
64
176
UGC12
NOMESCO Finland
Flexible bronchoscopy
0.7
11.2
370
4345
R44.3
ICD-10 Finland
Hallucinations, unspecified
3.8
11.2
47
103
SPAT1157
SPAT
Guidance concerning treatment of mouth and mucous membranes
2.4
11.1
95
334
G04CB02
ATC
dutasteride; oral
1.4
11.1
664
4145
N95.1
ICD-10 Finland
Menopausal and female climacteric states
0.5
11.0
84
1393
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
0.8
11.0
853
8868
J01.0
ICD-10 Finland
Acute maxillary sinusitis
0.8
11.0
691
7372
S01BC05
ATC
ketorolac; ophthalmic
1.5
11.0
324
1761
SPAT1153
SPAT
Removal of sutures
0.8
10.9
2217
20919
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
2.2
10.9
107
403
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
0.8
10.9
1779
17107
LAITO
NOMESCO Finland
NA
17.7
10.8
17
8
S22.3
ICD-10 Finland
Fracture of rib
1.4
10.8
455
2667
S01.8
ICD-10 Finland
Open wound of other parts of head
2.4
10.8
94
332
-1
ICPC
NA
1.9
10.7
148
642
F0021, G308
ICD-10 Finland
NA
+∞
10.7
11
*
N07AA06
ATC
NA
+∞
10.7
11
*
F0013, G301
ICD-10 Finland
NA
+∞
10.7
11
*
F000, G300
ICD-10 Finland
NA
+∞
10.7
11
*
F00.0
ICD-10 Finland
Dementia in Alzheimer disease with early onset
+∞
10.7
11
*
H25.1
ICD-10 Finland
Senile nuclear cataract
1.2
10.6
2770
20491
U28
ICPC
Limited function/disability (U)
2.3
10.6
97
353
IAB14
NOMESCO Finland
Geriatric psychiatry consultation
5.0
10.6
34
57
U13
ICPC
Bladder symptom/complaint other
1.7
10.6
227
1134
K91
ICPC
Cerebrovascular disease
2.1
10.5
122
493
AA5EN
NOMESCO Finland
Brain reseptor or transprot protein distribution isotope imaging
4.3
10.5
38
73
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
3.1
10.4
59
161
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
1.6
10.4
284
1512
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
3.9
10.4
42
89
S09.9
ICD-10 Finland
Unspecified injury of head
2.4
10.4
87
303
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
0.5
10.4
69
1192
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
2.6
10.4
77
252
R74
ICPC
Upper respiratory infection acute
0.8
10.3
806
8371
NF1AA
NOMESCO Finland
Hip X-ray examination
1.3
10.3
724
4628
S82
ICPC
Naevus/mole
0.7
10.3
513
5651
SPAT1240
SPAT
Therapeutic discussion
1.5
10.3
408
2364
WW500
NOMESCO Finland
Blood transfusion
0.6
10.3
117
1729
G04BD07
ATC
tolterodine; oral
1.4
10.3
422
2464
SPAT1294
SPAT
Other function in accordance with health social work nomenclature
1.8
10.2
184
873
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.2
10.2
3284
24695
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.1
10.2
120
488
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
0.6
10.2
166
2245
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
1.5
10.2
327
1813
S18
ICPC
Laceration/cut
0.9
10.2
2954
27134
E000001
ATC
NA
1.2
10.2
1256
8639
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
2.3
10.2
94
345
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
3.6
10.0
45
105
P15
ICPC
Chronic alcohol abuse
2.1
10.0
108
425
N06AX12
ATC
bupropion; oral
1.9
9.9
147
656
F05.0
ICD-10 Finland
Delirium not superimposed on dementia, so described
4.2
9.8
37
74
Z11
ICPC
Compliance/being ill problem
3.1
9.8
53
143
F02.34
ICD-10 Finland
Dementia in Parkinson's disease, other additional symptoms of mixed type
49.9
9.8
12
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
0.5
9.7
57
1026
F01.80
ICD-10 Finland
Other specified vascular dementia without additional symptoms
9.2
9.7
20
18
F02.82
ICD-10 Finland
Dementia in other specified disease that is classified elsewhere other symptoms, mainly hallucinations
+∞
9.7
10
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
1.8
9.7
155
708
A78
ICPC
Infectious disease other/NOS
2.5
9.7
72
236
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
1.5
9.6
335
1890
359
Kela drug reimbursment
Mirabegroni
2.6
9.6
68
216
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
3.8
9.6
40
88
ZXY02
NOMESCO Finland
Neuropsychologist
3.8
9.6
40
88
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
2.1
9.6
107
428
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
0.6
9.6
152
2065
C03CA01
ATC
furosemide; systemic
1.2
9.5
2858
21347
N05AN01
ATC
lithium; oral
2.1
9.5
102
402
S01
ICD-10 Finland
Open wound of head
2.2
9.5
91
339
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
0.7
9.5
215
2705
F32
ICD-10 Finland
Depressive episode
1.7
9.4
201
1004
A10AD05
ATC
insulin aspart; parenteral (insulins and analog. for injection, intermediate- or long-acting comb. with fast-acting)
1.8
9.4
157
729
F01.3
ICD-10 Finland
Mixed cortical and subcortical vascular dementia
5.1
9.4
29
47
KED22
NOMESCO Finland
Transurethral resection of prostate
1.3
9.4
601
3790
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
0.5
9.4
67
1130
N05CD07
ATC
temazepam; oral
1.2
9.4
1064
7249
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
5.3
9.3
28
44
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
0.8
9.3
1579
15171
S01.9
ICD-10 Finland
Open wound of head, part unspecified
2.0
9.3
111
455
IHZ08
SPAT
NA
19.4
9.3
14
6
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.2
9.2
2709
20185
N03AX18
ATC
lacosamide; systemic
3.4
9.2
43
104
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.2
9.2
1184
8179
I95.9
ICD-10 Finland
Hypotension, unspecified
2.0
9.2
117
494
C04AE01
ATC
ergoloid mesylates; systemic
2.5
9.2
69
228
115
Kela drug reimbursment
Breast cancer
0.7
9.1
274
3274
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
0.5
9.1
51
933
N06BA04
ATC
methylphenidate; oral
4.9
9.1
29
49
S20.2
ICD-10 Finland
Contusion of thorax
1.5
9.1
290
1607
S06.2
ICD-10 Finland
Diffuse brain injury
2.6
9.1
65
209
NG1AA
SPAT
NA
0.3
9.0
20
534
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
3.3
9.0
45
115
SPAT1058
SPAT
PEF monitoring instruction
0.7
9.0
366
4157
C01DA14
ATC
isosorbide mononitrate; oral
1.2
9.0
1610
11497
N04BC06
ATC
cabergoline; oral (dopamine agonists)
4.2
9.0
33
65
G23.9
ICD-10 Finland
Degenerative disease of basal ganglia, unspecified
4.2
9.0
33
65
P03
ICPC
Feeling depressed
1.5
8.9
290
1612
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
2.0
8.9
111
464
I67.4
ICD-10 Finland
Hypertensive encephalopathy
7.9
8.9
20
21
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
3.1
8.9
48
130
WX302
NOMESCO Finland
Thoracal epidural anesthesy
0.6
8.9
175
2264
Y94.1
ICD-10 Finland
Accident in connection with service housing
13.9
8.8
15
9
P76
ICPC
Depressive disorder
1.7
8.8
195
986
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.4
8.8
402
2398
SPAT1255
SPAT
Intravenous administration of medicine
1.4
8.8
473
2903
L15
ICPC
Knee symptom/complaint
0.8
8.7
1127
11103
F00.02
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset other additional symptoms, mainly illusions
+∞
8.7
9
*
WX111
NOMESCO Finland
Local infiltration anesthesia
0.6
8.7
103
1502
PJA12
NOMESCO Finland
Sentinel node biopsy
0.7
8.7
254
3048
R03AK07
ATC
formoterol and budesonide; inhalant
0.8
8.7
701
7259
F02.8
ICD-10 Finland
Dementia in other specified diseases classified elsewhere
83.2
8.7
10
*
N05AA02
ATC
levomepromazine; systemic
1.6
8.7
229
1213
S42.2
ICD-10 Finland
Fracture of upper end of humerus
1.5
8.7
323
1850
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
2.4
8.6
69
236
TQW40
NOMESCO Finland
Remowal of suture of skin
0.7
8.6
240
2903
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
0.8
8.6
499
5385
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
1.5
8.6
338
1959
M70.6
ICD-10 Finland
Trochanteric bursitis
0.8
8.6
579
6122
128
Kela drug reimbursment
Cancers of female genital organs
0.4
8.6
25
590
N88
ICPC
Epilepsy
3.4
8.5
41
102
N80
ICPC
Head injury other
2.0
8.5
110
467
N04BB01
ATC
amantadine; oral
2.0
8.5
108
456
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
0.6
8.5
181
2307
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
3.4
8.5
40
98
G23.1
ICD-10 Finland
Progressive supranuclear ophthalmoplegia [Steele-Richardson-Olszewski]
4.9
8.5
27
46
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
2.8
8.5
53
157
D17
ICPC
Incontinence of bowel
2.4
8.4
71
250
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.2
8.4
1754
12687
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
1.6
8.4
231
1234
Z08
ICPC
Social welfare problem
2.6
8.4
61
198
TGC00
NOMESCO Finland
Bronchial lavation
0.5
8.4
66
1079
R40.2
ICD-10 Finland
Coma, unspecified
2.5
8.4
67
228
SPAT1243
SPAT
Psychiatric/psychological examination
2.4
8.4
70
244
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.3
8.4
716
4708
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
0.3
8.4
21
527
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.8
8.3
1425
13692
HA1AA
NOMESCO Finland
X-ray mammography
0.7
8.3
243
2913
EBA30
NOMESCO Finland
Excision of root of tooth
1.4
8.2
361
2135
S06.9
ICD-10 Finland
Intracranial injury, unspecified
2.9
8.2
48
137
C09CA06
ATC
candesartan; oral
0.8
8.2
1081
10636
P99
ICPC
Psychological disorders other
2.1
8.2
87
340
G04BD11
ATC
fesoterodine; oral
1.5
8.2
253
1394
WF003
NOMESCO Finland
Adjuvant radiotherapy
0.6
8.1
104
1485
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
0.7
8.1
223
2705
R2110
NOMESCO Finland
Giving the first information
1.4
8.1
358
2123
F09
ICD-10 Finland
Unspecified organic or symptomatic mental disorder
7.9
8.1
18
19
F0232, G20
ICD-10 Finland
NA
20.0
8.1
12
5
F10.20
ICD-10 Finland
Alcohol dependence currently independent
2.1
8.0
86
339
R02
ICPC
Shortness of breath/dyspnoea
0.8
8.0
622
6470
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.0
7.9
43
118
G04BD10
ATC
darifenacin; oral
2.4
7.9
62
212
C34.12
ICD-10 Finland
Malignant tumor of the anterior, bronchial or pulmonary adenocarcinoma
0.3
7.9
20
498
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
2.3
7.9
67
238
SAD02
NOMESCO Finland
Assessment of need for oral health care, extensive
1.8
7.9
141
672
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
0.8
7.9
681
6993
Z75.0
ICD-10 Finland
Medical services not available in home
4.8
7.8
25
43
J01DB01
ATC
cefalexin; oral
1.1
7.8
6094
48402
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
0.5
7.8
63
1020
L76
ICPC
Fracture: other
1.6
7.8
196
1029
S01.41
ICD-10 Finland
Open wound in the temple-jaw region
2.3
7.8
67
240
F02.3
ICD-10 Finland
Dementia in Parkinson disease
74.9
7.8
9
*
NE1AD
NOMESCO Finland
Pelvis and hip bones CT examination
1.7
7.8
147
712
F0021, G301
ICD-10 Finland
NA
+∞
7.8
8
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
0.7
7.7
232
2766
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
0.5
7.7
74
1140
R45.5
ICD-10 Finland
Hostility
11.6
7.7
14
10
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
2.6
7.7
53
167
C10AA05
ATC
atorvastatin; oral
1.1
7.7
3524
27014
F01.8
ICD-10 Finland
Other vascular dementia
8.9
7.7
16
15
F10.25
ICD-10 Finland
Alcohol dependence continuous use
2.2
7.7
79
306
IGY02
NOMESCO Finland
Psychiatric monitoring contact
2.4
7.7
64
226
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
1.9
7.7
117
528
XKD00
NOMESCO Finland
Uroflowmetry
1.2
7.7
1578
11392
J01FA10
ATC
azithromycin; systemic
0.9
7.7
2808
25525
G04CA52
ATC
tamsulosin and dutasteride; systemic
1.2
7.7
925
6343
R45.1
ICD-10 Finland
Restlessness and agitation
6.2
7.7
20
27
C10AA02
ATC
lovastatin; oral
1.4
7.6
376
2273
N02AX02
ATC
tramadol; systemic, rectal
0.9
7.6
2706
24655
C10AX09
ATC
ezetimibe; oral
0.8
7.6
607
6295
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.2
7.6
1598
11560
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
0.8
7.6
427
4622
WX600
NOMESCO Finland
Single shot through catheter
0.2
7.5
7
300
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
2.4
7.5
60
207
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
1.6
7.5
198
1050
D21
ICPC
Swallowing problem
1.9
7.5
106
465
Z20.8
ICD-10 Finland
Contact with and exposure to other communicable diseases
1.6
7.5
182
945
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
1.8
7.5
120
552
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
2.2
7.5
75
286
ZYC01
SPAT
NA
1.5
7.5
261
1475
A10BB12
ATC
glimepiride; oral
1.3
7.5
643
4228
R05
ICPC
Cough
0.8
7.5
1134
11024
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
4.2
7.5
27
53
L03AA14
ATC
lipegfilgrastim; parenteral
0.4
7.4
23
527
81
HP
Angiography of the heart and coronary arteries
1.3
7.4
627
4118
W00
ICD-10 Finland
Fall on same level involving ice and snow
1.3
7.4
671
4446
Z43.5
ICD-10 Finland
Attention to cystostomy
2.7
7.4
49
153
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
2.6
7.4
52
168
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
1.2
7.4
1085
7593
AA5NK
NOMESCO Finland
Tractography within white matter of central nervous system
27.7
7.4
10
*
F02.31
ICD-10 Finland
Dementia in Parkinson's disease other additional symptoms, mainly paranoidism
27.7
7.4
10
*
OAB43
SPAT
NA
0.4
7.4
30
614
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
0.9
7.3
2616
23837
M04AA01
ATC
allopurinol; systemic
0.8
7.3
848
8450
N03AX09
ATC
lamotrigine; oral
1.7
7.3
136
658
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
0.5
7.3
50
851
M25.5
ICD-10 Finland
Pain in joint
0.8
7.3
1278
12262
B01AC04
ATC
clopidogrel; oral
1.2
7.2
1495
10793
Z60.9
ICD-10 Finland
Problem related to social environment, unspecified
4.2
7.2
26
51
XA400
NOMESCO Finland
EEG
2.8
7.2
44
131
Z59.8
ICD-10 Finland
Other problems related to housing and economic circumstances
6.5
7.2
18
23
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
0.2
7.2
9
324
4289X
ICD-9 Finland
Heart failure, unspecified
0.2
7.2
5
256
G41.9
ICD-10 Finland
Status epilepticus, unspecified
2.7
7.2
47
146
SPAT1297
SPAT
Other function in accordance with speech therapy nomenclature
2.8
7.1
43
127
K80
ICPC
Cardiac arrhythmia NOS
0.7
7.1
344
3802
A12AA04
ATC
calcium carbonate; oral
0.4
7.1
26
556
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
1.6
7.1
164
844
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
2.3
7.0
62
227
A69.2
ICD-10 Finland
Lyme disease
0.7
7.0
161
2012
NF1BA
NOMESCO Finland
Hip extensive X-ray examination
1.4
7.0
270
1566
U29
ICPC
Urinary symptom/complaint other
1.6
7.0
196
1058
IGY99
NOMESCO Finland
Other psychiatric treatment contact
2.8
6.9
44
133
F02.09
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
12.5
6.9
12
8
Z01.4
ICD-10 Finland
Gynaecological examination (general)(routine)
0.8
6.9
367
4000
N04BC02
ATC
pergolide; oral
5.6
6.9
19
28
Z74.1
ICD-10 Finland
Need for assistance with personal care
20.8
6.9
10
*
GD1CT
NOMESCO Finland
Biopsy of the lung with CT guidance
0.4
6.9
28
571
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
0.7
6.8
212
2512
S21
ICPC
Skin texture symptom/complaint
0.8
6.8
645
6564
A04AD12
ATC
aprepitant; systemic
0.4
6.8
24
521
R54
ICD-10 Finland
Senility
2.9
6.8
40
116
S20
ICPC
Corn/callosity
1.6
6.8
155
793
SPAT1277
SPAT
Instruction concerning legal protection and patient’s rights
4.7
6.8
22
39
LAF11
NOMESCO Finland
Laparoscopic bilateral salpingo-oophorectomy
0.6
6.8
136
1750
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
2.4
6.8
54
186
F0019, G309
ICD-10 Finland
NA
+∞
6.8
7
*
F0282, G318
ICD-10 Finland
NA
+∞
6.8
7
*
F009, G301
ICD-10 Finland
NA
+∞
6.8
7
*
F00.03
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenil onset other additional symptoms, mainly depression
+∞
6.8
7
*
F02.04
ICD-10 Finland
Dementia in Pick's disease other additional symptoms of mixed type
+∞
6.8
7
*
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
0.7
6.8
157
1963
B01AB05
ATC
enoxaparin; parenteral
0.9
6.8
2056
18959
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
0.8
6.8
1152
11093
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
0.2
6.8
9
313
TK800
NOMESCO Finland
Hemodialysis
0.5
6.8
47
798
I95.0
ICD-10 Finland
Idiopathic hypotension
4.3
6.7
24
47
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
0.5
6.7
49
819
R5110
SPAT
NA
1.5
6.7
189
1022
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
1.8
6.7
118
560
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
2.4
6.7
53
181
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
3.6
6.7
29
68
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
1.8
6.7
107
495
B01AC07
ATC
dipyridamole; systemic
1.3
6.7
432
2738
FN2BA
NOMESCO Finland
Percutaneous transluminal coronary angioplasty with stent (includes balloon pre-dilation)
0.7
6.6
274
3100
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.2
6.6
1165
8290
R06.0
ICD-10 Finland
Dyspnoea
0.9
6.6
1602
15012
P04
ICPC
Feeling/behaving irritable/angry
4.2
6.6
24
48
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
0.5
6.6
69
1037
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
0.7
6.6
328
3610
F30.1
ICD-10 Finland
Mania without psychotic symptoms
7.3
6.6
15
17
I68.0
ICD-10 Finland
Cerebral amyloid angiopathy
6.7
6.6
16
20
4148X
ICD-9 Finland
Other forms of chronic ischaemic heart disease, Other specified forms of chronic ischaemic heart disease[MORBUS CORDIS ISCHAEMICUS ALIA,MÄÄRITTELEMÄT]
0.3
6.6
13
366
L90
ICPC
Osteoarthrosis of knee
0.7
6.5
299
3330
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
0.7
6.5
228
2649
G04CA01
ATC
alfuzosin; oral
1.2
6.5
1022
7200
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
1.6
6.5
166
878
R31
ICD-10 Finland
Unspecified haematuria
1.2
6.5
861
5964
K03.64
ICD-10 Finland
Dental calculus supragingival
0.8
6.4
1015
9835
Z25.8
ICD-10 Finland
Need for immunization against other specified single viral diseases
0.8
6.4
367
3960
F20.9
ICD-10 Finland
Schizophrenia, unspecified
2.0
6.4
79
334
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
2.7
6.4
41
125
I64
ICD-10 Finland
Stroke, not specified as haemorrhage or infarction
2.4
6.4
52
183
L01CA04
ATC
vinorelbine; systemic
0.3
6.4
11
329
D38.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Trachea, bronchus and lung
0.6
6.4
98
1333
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
0.7
6.4
177
2137
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
1.4
6.3
326
1990
SPAT1111
SPAT
Planning of analgesia
2.0
6.3
78
328
SPAT1293
SPAT
Other function in accordance with rehabilitation guidance nomenclature
2.5
6.3
46
153
8140/3-C34.3
ICD-O-3
Adenocarcinoma, NOS, of lower lobe, lung
0.1
6.3
*
181
S02.51
ICD-10 Finland
Fracture of tooth, open
0.7
6.3
299
3311
ZXE00
NOMESCO Finland
One hour or less
0.9
6.3
2355
21445
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
1.2
6.3
850
5896
65000
ICD-8 Finland
Delivery without mention of complication, Occipital presentation
0.9
6.3
1219
11616
R47.1
ICD-10 Finland
Dysarthria and anarthria
2.0
6.3
71
289
S00.8
ICD-10 Finland
Superficial injury of other parts of head
2.0
6.3
78
331
F01.33
ICD-10 Finland
Mixed cortical and subcortical vascular dementia other additional symptoms, mainly depression
10.0
6.3
12
10
J45
ICD-10 Finland
Asthma
0.8
6.2
350
3787
EB1AA
SPAT
NA
0.6
6.2
99
1339
P01BA02
ATC
hydroxychloroquine; oral
0.7
6.2
309
3400
K59.1
ICD-10 Finland
Functional diarrhoea
1.4
6.2
335
2063
HA1RA
NOMESCO Finland
Combined assessment of mammary gland (mammography and ultrasound)
0.4
6.2
23
487
N05AF05
ATC
zuclopenthixol; systemic
2.4
6.2
50
173
R21
ICPC
Throat symptom/complaint
0.8
6.2
541
5552
L04AA06
ATC
mycophenolic acid; systemic
0.3
6.2
17
411
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.3
6.2
451
2905
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
0.8
6.2
1015
9807
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
0.8
6.2
591
6008
F02.84
ICD-10 Finland
Dementia in another specified disease that is classified elsewhere as other mixed symptoms of mixed type
33.2
6.2
8
*
P01
ICPC
Feeling anxious/nervous/tense
1.4
6.2
254
1492
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
0.7
6.2
188
2234
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
6.0
6.2
16
22
T93
ICPC
Lipid disorder
0.7
6.2
245
2785
IGP01
NOMESCO Finland
Psychiatric family contact
4.6
6.2
20
36
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
1.4
6.2
255
1500
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
2.9
6.1
36
105
G21.0
ICD-10 Finland
Malignant neuroleptic syndrome
11.4
6.1
11
8
H04AA01
ATC
glucagon; nasal, parenteral
2.0
6.1
68
278
F01.21
ICD-10 Finland
Subcortical vascular dementia without additional symptoms, mainly paranoidism
13.9
6.1
10
6
N05CF01
ATC
zopiclone; oral
1.1
6.0
2501
18973
ZXD35
NOMESCO Finland
Usual procedure
1.5
6.0
205
1157
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
0.7
6.0
185
2194
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.1
6.0
2990
22937
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
1.6
6.0
139
717
D70.82
ICD-10 Finland
Drug-induced neutropenia
0.4
6.0
27
533
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
2.8
6.0
36
107
R40.0
ICD-10 Finland
Somnolence
3.8
6.0
24
53
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
1.7
6.0
115
562
S15
ICPC
Foreign body in skin
0.7
6.0
248
2802

Mortality – FinRegistry

Association

Association between endpoint G6_AD_WIDE and mortality.

Females

Parameter HR [95% CI] p-value
G6_AD_WIDE 2.209 [2.02, 2.41] < 0.001
Birth year 0.987 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 94565 out of 156946 females with G6_AD_WIDE died.

Males

Parameter HR [95% CI] p-value
G6_AD_WIDE 2.25 [2.01, 2.52] < 0.001
Birth year 0.984 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 57338 out of 92451 males with G6_AD_WIDE died.

Mortality risk

Mortality risk for people of age

years, who have G6_AD_WIDE.

N-year risk Females Males
1 0.116% 0.358%
5 0.728% 2.175%
10 1.889% 5.058%
15 3.633% 9.382%
20 6.035% 15.046%

Relationships between endpoints

Index endpoint: G6_AD_WIDE – Alzheimer’s disease, wide definition

GWS hits: 21

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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