No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2399 |
4. Check minimum number of eventsNone |
2399 |
5. Include endpointsNone |
2399 |
6. Filter based on genotype QC (FinnGen only) |
2399 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H52
- Name in latin
- Presbyopia
Similar endpoints
↥List of similar endpoints to
Presbyopia
based on the number of shared cases.
Similar with more cases:
- Disorders of refraction and accommodation
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12798 | 7185 | 5554 |
| Only index persons | 11977 | 6753 | 5224 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.21 | 0.16 |
| Only index persons | 0.23 | 0.25 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 53.91 | 54.12 | 53.65 |
| Only index persons | 53.71 | 53.84 | 53.55 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2399 | 1524 | 875 |
| Unadjusted period prevalence (%) | 0.47 | 0.52 | 0.39 |
| Median age at first event (years) | 54.84 | 54.35 | 55.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2029
- Matched controls
- 20289
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H52.4
ICD-10 Finland
Presbyopia
1710.1
323.0
1887
151
H52.0
ICD-10 Finland
Hypermetropia
78.4
198.7
224
32
H52.1
ICD-10 Finland
Myopia
28.7
150.4
207
80
37002
ICD-8 Finland
Refractive errors, Myopia
+∞
149.9
142
*
H52.2
ICD-10 Finland
Astigmatism
51.0
121.8
147
31
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.7
59.6
489
2134
CGD20
NOMESCO Finland
Laser-assisted in situ keratomileusis
305.8
58.6
59
*
CJE40
NOMESCO Finland
Phakoemulsification with implantation of skleralt fixed artificial lens in posterior chamber
305.8
58.6
59
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
57.8
901
5436
XCK00
NOMESCO Finland
Perimetry
3.6
38.2
184
546
H50.52
ICD-10 Finland
Exophoria
41.7
33.1
41
10
H04.10
ICD-10 Finland
Dry eye syndrome
2.6
32.5
267
1130
37301
ICD-8 Finland
Strabismus, Concomitans divergens
+∞
32.4
31
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.9
31.3
633
3969
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
27.9
24.5
33
12
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.4
21.3
188
823
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.3
21.3
215
1004
N03AX12
ATC
gabapentin; oral
1.9
19.9
331
1898
H53.2
ICD-10 Finland
Diplopia
4.3
19.4
73
175
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
18.4
303
1728
R51.80
ICD-10 Finland
Headache
1.9
18.3
298
1690
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
17.7
17
*
ZXA10
NOMESCO Finland
Bilateral
1.8
17.6
337
2019
H53.1
ICD-10 Finland
Subjective visual disturbances
2.4
17.2
147
631
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.1
14.9
167
814
H50.1
ICD-10 Finland
Divergent concomitant strabismus
57.1
14.8
17
*
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
+∞
14.6
14
*
H50.31
ICD-10 Finland
Intermittent exotropia
151.0
14.5
15
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.2
14.2
151
722
N02AX02
ATC
tramadol; systemic, rectal
1.5
14.1
807
6327
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.1
13.8
164
824
A02BC05
ATC
esomeprazole; systemic
1.4
13.4
780
6115
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
13.2
394
2664
AA1AD
NOMESCO Finland
CT of head and brain
1.6
12.7
394
2689
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
12.1
635
4855
H25.0
ICD-10 Finland
Senile incipient cataract
2.5
12.0
96
398
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
11.8
663
5130
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
11.8
159
836
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
11.5
11
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.6
11.1
291
1894
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.9
10.9
168
933
37600
ICD-8 Finland
Detachment of retina, Primaria
28.2
10.7
14
5
N03AX16
ATC
pregabalin; oral
1.5
10.7
441
3199
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.3
10.7
100
454
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
10.6
191
1116
R42
ICD-10 Finland
Dizziness and giddiness
1.5
10.6
342
2347
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.3
10.5
52
162
H52.5
ICD-10 Finland
Disorders of accommodation
+∞
10.4
10
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
10.3
166
935
H50.51
ICD-10 Finland
Esophoria
40.3
10.0
12
*
H26.4
ICD-10 Finland
After-cataract
2.1
9.9
109
532
G44.2
ICD-10 Finland
Tension-type headache
1.6
9.6
241
1550
R06.0
ICD-10 Finland
Dyspnoea
1.5
9.5
394
2852
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
9.4
9
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
9.4
9
*
A02BC03
ATC
lansoprazole; oral
1.4
9.2
526
4048
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
9.2
385
2793
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
9.1
520
3999
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
9.1
711
5768
E0000UV
ATC
NA
1.4
8.9
675
5442
R20.2
ICD-10 Finland
Paraesthesia of skin
1.9
8.8
126
682
M03BX02
ATC
tizanidine; oral
1.3
8.7
1269
11281
H54.7
ICD-10 Finland
Unspecified visual loss
7.2
8.7
20
28
N02BE01
ATC
paracetamol; systemic, rectal
1.4
8.7
1652
15333
K30
ICD-10 Finland
Functional dyspepsia
1.7
8.6
186
1147
A02BC02
ATC
pantoprazole; systemic
1.3
8.6
1199
10581
H50.2
ICD-10 Finland
Vertical strabismus
27.6
8.5
11
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
8.4
854
7186
G35
ICD-10 Finland
Multiple sclerosis
3.2
8.4
42
133
R03AC03
ATC
terbutaline; inhalant
1.6
8.4
251
1689
H02AB06
ATC
prednisolone; systemic
1.3
8.3
837
7030
UJF32
NOMESCO Finland
Coloscopy
1.4
8.3
428
3226
H46
ICD-10 Finland
Optic neuritis
4.8
8.2
26
55
X59
ICD-10 Finland
Exposure to unspecified factor
1.5
8.1
310
2206
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
4.0
8.1
30
75
R07.4
ICD-10 Finland
Chest pain, unspecified
1.4
7.8
455
3498
N06AX16
ATC
venlafaxine; oral
1.5
7.8
257
1768
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
7.6
402
3035
R06AX27
ATC
desloratadine; oral
1.4
7.5
499
3919
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.6
7.5
181
1152
N06AX21
ATC
duloxetine; oral
1.6
7.5
210
1391
M25.5
ICD-10 Finland
Pain in joint
1.3
7.4
522
4142
H51.1
ICD-10 Finland
Convergence insufficiency and excess
+∞
7.3
7
*
J02AC01
ATC
fluconazole; systemic
1.3
7.2
782
6600
ZXE00
NOMESCO Finland
One hour or less
1.3
7.2
688
5701
M79.6
ICD-10 Finland
Pain in limb
1.3
7.2
618
5048
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.4
7.2
378
2850
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
1.9
7.2
105
576
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
7.1
673
5568
XF400
NOMESCO Finland
ECG with 12 standard connections
1.5
7.0
240
1664
N06AA09
ATC
amitriptyline; systemic
1.6
6.9
171
1098
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.4
6.9
456
3576
F51.0
ICD-10 Finland
Nonorganic insomnia
1.5
6.9
226
1552
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
2.4
6.8
55
235
H53.0
ICD-10 Finland
Amblyopia ex anopsia
6.1
6.8
17
28
CJE99
NOMESCO Finland
Other extracapsular cataract operation using phakoemulsification technique
40.2
6.8
8
*
37602
ICD-8 Finland
Detachment of retina, Foramen, ruptura retinae
40.2
6.8
8
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.4
6.7
370
2814
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.6
6.7
156
987
H02.3
ICD-10 Finland
Blepharochalasis
1.8
6.7
103
577
Z3226
NOMESCO Finland
Physiotherapist
1.4
6.6
299
2196
UKC02
NOMESCO Finland
Cystoscopy
1.5
6.6
217
1492
SPAT1312
SPAT
General health counselling
1.3
6.6
482
3836
N06AX11
ATC
mirtazapine; oral
1.3
6.4
558
4551
L04AX01
ATC
azathioprine; systemic
2.0
6.4
77
395
M54.2
ICD-10 Finland
Cervicalgia
1.7
6.4
133
816
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
3.7
6.3
25
68
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.3
6.3
52
227
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
2.9
6.3
36
126
R35
ICD-10 Finland
Polyuria
1.8
6.2
92
508
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.8
6.2
108
627
N03AF02
ATC
oxcarbazepine; oral
2.3
6.2
52
228
R01AD12
ATC
fluticasone furoate; nasal
1.3
6.2
527
4281
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
1.9
6.2
83
440
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.5
6.2
184
1237
Z2221
NOMESCO Finland
Medical doctor
1.3
6.2
462
3685
A98
ICPC
Health maint/preventive medicine
1.7
6.2
1931
18715
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
6.1
269
1961
109
Kela drug reimbursment
Multiple sclerosis
3.3
6.1
28
86
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.6
6.0
163
1071
WX408
NOMESCO Finland
General anesthesy, balanced
1.3
6.0
459
3669
Mortality – FinRegistry
↥Association
Association between endpoint H7_PRESBYOPIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PRESBYOPIA | 1.379 [1.18, 1.61] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.285 |
During the follow-up period (1.1.1998 — 31.12.2019), 328 out of 3648 females with H7_PRESBYOPIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PRESBYOPIA | 1.398 [1.2, 1.63] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 432 out of 2916 males with H7_PRESBYOPIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_PRESBYOPIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.295% |
| 5 | 0.843% | 1.703% |
| 10 | 2.094% | 4.247% |
| 15 | 4.011% | 8.649% |
| 20 | 7.218% | 14.601% |
Relationships between endpoints
↥Index endpoint: H7_PRESBYOPIA – Presbyopia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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