nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
8583 |
4. Check minimum number of eventsNone |
8583 |
5. Include endpointsNone |
8583 |
6. Filter based on genotype QC (FinnGen only) |
8583 |
Control definitions (FinnGen only)
- Control exclude
- E4_THYROID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E04
- Name in latin
- Struma atoxica multinodularis
Similar endpoints
↥List of similar endpoints to
Nontoxic multinodular goitre
based on the number of shared cases.
Similar with more cases:
- Nontoxic goitre/thyroid nodule
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 61722 | 52630 | 8754 |
| Only index persons | 53558 | 46255 | 7303 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.32 | 1.51 | 0.24 |
| Only index persons | 1.51 | 1.70 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 53.21 | 52.57 | 57.09 |
| Only index persons | 52.22 | 51.51 | 56.67 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 8583 | 7235 | 1348 |
| Unadjusted period prevalence (%) | 2.17 | 2.47 | 0.59 |
| Median age at first event (years) | 52.54 | 51.15 | 60.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 7696
- Matched controls
- 76958
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
110.3
323.0
1443
161
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
36.6
323.0
630
187
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
211.9
323.0
1779
109
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
4276.8
323.0
792
*
E03
ICD-10 Finland
Other hypothyroidism
74.8
323.0
677
99
H03BB01
ATC
carbimazole; oral
67.4
323.0
403
63
D44.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Thyroid gland
33.7
323.0
454
143
104
Kela drug reimbursment
Thyroid insufficiency
875.1
323.0
1917
29
E03.89
ICD-10 Finland
Other specified hypothyroidism
227.9
323.0
511
24
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
570.2
323.0
381
7
24199
ICD-8 Finland
Non-toxic nodular goitre, Unspecified
+∞
323.0
1156
*
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
220.5
323.0
437
21
E04.1
ICD-10 Finland
Nontoxic single thyroid nodule
147.8
323.0
650
48
2411A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic multinodular goitre
+∞
323.0
501
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2023.0
323.0
5999
132
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
102.4
323.0
1238
144
H03AA01
ATC
levothyroxine sodium; systemic
92.9
323.0
4080
922
T86
ICPC
Hypothyroidism/myxoedema
59.8
323.0
467
83
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
37.2
323.0
708
209
BAA60
NOMESCO Finland
Total thyroidectomy
1430.8
323.0
1406
12
EP1AE
NOMESCO Finland
Neck ultrasound examination
7.8
323.0
1115
1635
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
154.6
321.8
340
23
2505
FHL
Bilateral resection (also used if total removal has been performed on the other side)
125.4
312.1
336
28
2504
FHL
Unilateral resection or enucleation
87.9
307.4
344
41
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
300.9
284.3
288
10
24110
ICD-8 Finland
Non-toxic nodular goitre, Sporadic
+∞
255.6
244
*
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
777.9
231.5
227
*
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
90.8
205.5
229
26
BAA20
NOMESCO Finland
Unilateral partial excision of thyroid gland
335.5
196.5
198
6
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
10.5
169.4
342
338
T81
ICPC
Goitre
50.4
158.1
192
39
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
528.6
157.4
156
*
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
+∞
156.8
150
*
E04.8
ICD-10 Finland
Other specified nontoxic goitre
115.9
146.6
159
14
D34
ICD-10 Finland
Benign neoplasm of thyroid gland
22.5
134.4
198
90
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
83.9
131.7
148
18
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
152.6
127.6
135
9
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
+∞
108.6
104
*
E04
ICD-10 Finland
Other nontoxic goitre
32.8
107.1
142
44
24100
ICD-8 Finland
Non-toxic nodular goitre, Endemic
+∞
106.5
102
*
JN5PN
NOMESCO Finland
Isotope imaging of secondary neoplasms of thyroid origin
519.8
103.9
103
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
94.7
3137
22392
106
Kela drug reimbursment
Hypoparathyroidism
57.6
91.3
108
19
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.1
86.5
525
1801
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
60.2
86.0
101
17
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
84.3
2066
13385
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
77.9
2870
20743
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
77.0
1668
10347
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
370.9
73.8
74
*
N02BE01
ATC
paracetamol; systemic, rectal
1.8
72.5
6634
59787
C73.92
ICD-10 Finland
Follicular carcinoma of the thyroid gland
355.5
70.7
71
*
R13
ICD-10 Finland
Dysphagia
2.5
69.2
570
2350
2419X
ICD-9 Finland
Non-toxic nodular goitre, Unspecified non-toxic nodular goitre
+∞
68.8
66
*
R22.1
ICD-10 Finland
Localized swelling, mass and lump, neck
3.4
68.0
354
1084
A11CC03
ATC
alfacalcidol; systemic
4.7
64.2
229
501
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
+∞
61.5
59
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
60.9
1638
10723
EN1BD
NOMESCO Finland
Very extensive CT examination of mouth and soft tissues of neck
5.2
60.3
196
388
T72
ICPC
Benign neoplasm thyroid
21.5
57.4
85
40
E06.1
ICD-10 Finland
Subacute thyroiditis
+∞
57.3
55
*
R03AC02
ATC
salbutamol; inhalant
1.5
56.9
3786
30569
JN5AQ
NOMESCO Finland
SPECT of thyroid metastasis with low-dose CT
+∞
55.3
53
*
E83.51
ICD-10 Finland
Hypocalcemia
12.8
55.0
99
78
GB1AA
NOMESCO Finland
Tracheal X-ray examination
146.1
54.9
58
*
A02BC05
ATC
esomeprazole; systemic
1.5
51.7
3052
23874
A11CC02
ATC
dihydrotachysterol; oral
33.8
51.3
67
20
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
+∞
51.1
49
*
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
49.1
1981
14244
TBA20
NOMESCO Finland
Aspiration cytology of thyroid gland
+∞
49.0
47
*
2410A
ICD-9 Finland
Non-toxic nodular goitre, Non-toxic uninodular goitre
+∞
48.0
46
*
8330/3-C73.9
ICD-O-3
Follicular carcinoma, NOS, of thyroid gland
164.3
46.9
49
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
46.3
3074
24428
2506
FHL
Thyroidectomy
160.9
45.8
48
*
BBA30
NOMESCO Finland
Excision of lesion of parathyroid gland
4.6
45.0
160
350
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
3.5
45.0
216
621
T85
ICPC
Hyperthyroidism/thyrotoxicosis
27.9
44.7
61
22
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.5
44.3
2084
15425
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
26.7
44.1
61
23
R01AD09
ATC
mometasone; nasal
1.4
44.1
3092
24751
G47.3
ICD-10 Finland
Sleep apnoea
1.6
43.7
1196
7782
BA1AE
SPAT
NA
8.9
42.1
91
103
ZXA05
NOMESCO Finland
Left side
1.5
41.5
1962
14503
4CJ01
NOMESCO Finland
NA
211.1
40.9
42
*
R06.0
ICD-10 Finland
Dyspnoea
1.5
40.7
1791
13024
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
+∞
40.6
39
*
R49.01
ICD-10 Finland
Functional dysphonia
2.8
40.4
280
1042
ZXA00
NOMESCO Finland
Right side
1.5
40.3
2070
15538
E06.3
ICD-10 Finland
Autoimmune thyroiditis
20.1
40.0
60
30
C73.99
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland), other or unspecified histology
88.5
39.8
44
5
C73
ICD-10 Finland
Malignant neoplasm of thyroid gland
64.6
39.1
45
7
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
38.7
2449
19105
C73.90
ICD-10 Finland
Malignant tumor of the thyroid gland (thyroid gland) without histology
56.5
38.3
45
8
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
+∞
37.5
36
*
J01DB01
ATC
cefalexin; oral
1.4
37.4
5831
52928
J01AA02
ATC
doxycycline; systemic
1.4
36.8
5763
52241
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
+∞
36.5
35
*
C07AB07
ATC
bisoprolol; oral
1.4
36.1
3379
28091
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
359.0
36.0
36
*
J01FA10
ATC
azithromycin; systemic
1.3
34.9
3938
33658
EN1AD
NOMESCO Finland
CT examination of mouth and soft tissues of neck
5.6
34.8
103
185
A02BC02
ATC
pantoprazole; systemic
1.4
34.6
4744
41778
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
25.4
34.4
48
19
BAA30
NOMESCO Finland
Excision of thyroid isthmus
76.5
33.8
38
5
J01FA06
ATC
roxithromycin; oral
1.4
33.5
2898
23685
SPAT1153
SPAT
Removal of sutures
1.4
33.5
2284
17941
24099
ICD-8 Finland
Simple goitre, Unspecified
+∞
33.3
32
*
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.7
31.6
224
846
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
12.8
31.5
56
44
WX402
NOMESCO Finland
General anaesthesia
1.5
31.4
1080
7385
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
6.8
31.3
80
119
S18
ICPC
Laceration/cut
1.3
30.7
2893
23863
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
30.3
1232
8737
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
30.0
4246
37153
UJF32
NOMESCO Finland
Coloscopy
1.4
29.5
1834
14109
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
29.2
2759
22714
BA1NN
NOMESCO Finland
I-131 dose capsel measurement
+∞
29.2
28
*
M79.6
ICD-10 Finland
Pain in limb
1.3
29.0
2525
20525
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
28.8
1832
14143
R07.0
ICD-10 Finland
Pain in throat
2.0
28.8
381
1948
SPAT1263
SPAT
Sampling
1.3
28.6
2900
24103
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.4
28.6
1406
10351
ZXA10
NOMESCO Finland
Bilateral
1.4
28.5
1369
10033
BWD00
NOMESCO Finland
Reoperation for deep haemorrhage in endocrine surgery
55.2
28.1
33
6
R53
ICD-10 Finland
Malaise and fatigue
1.4
27.7
1353
9938
M03BX02
ATC
tizanidine; oral
1.3
27.6
4211
37021
R03DC03
ATC
montelukast; oral
1.5
27.3
1058
7414
E20.8
ICD-10 Finland
Other hypoparathyroidism
75.4
26.8
30
*
T71
ICPC
Malignant neoplasm thyroid
272.0
26.7
27
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
26.6
1086
7685
M54.5
ICD-10 Finland
Low back pain
1.3
26.5
2151
17236
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.3
26.4
2518
20672
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
26.3
1415
10571
ZX114
NOMESCO Finland
Intramuscular
3.7
25.9
116
318
B01AB05
ATC
enoxaparin; parenteral
1.3
25.9
2189
17640
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.4
25.8
1246
9125
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
25.7
2642
21905
DQE10
NOMESCO Finland
Injection of foreign material into vocal cord
12.5
25.7
46
37
R42
ICD-10 Finland
Dizziness and giddiness
1.4
25.5
1576
12064
N02AX02
ATC
tramadol; systemic, rectal
1.3
25.3
2807
23513
H02AB06
ATC
prednisolone; systemic
1.3
25.3
3151
26813
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.3
25.2
3205
27347
R21
ICPC
Throat symptom/complaint
1.5
24.6
1089
7826
R49.08
ICD-10 Finland
Other specified dysphonia
2.6
24.6
181
701
ZSB00
NOMESCO Finland
Procedure related to previous procedure classified in chapter B
34.6
24.2
31
9
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.4
24.2
1141
8303
J37.0
ICD-10 Finland
Chronic laryngitis
2.3
24.2
224
979
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.6
24.0
666
4308
2440A
ICD-9 Finland
Acquired hypothyroidism, Postsurgical hypothyroidism
+∞
24.0
23
*
GD6BD
NOMESCO Finland
Extensive CT of chest and neck
11.1
23.3
44
40
R01AD12
ATC
fluticasone furoate; nasal
1.3
23.1
1767
13972
2409X
ICD-9 Finland
Simple and unspecified goitre, Goitre, unspecified
22.1
22.9
33
15
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.6
22.9
671
4399
J01DA01
ATC
[U] cefalexin; systemic
1.3
22.7
4322
38620
BAA99
NOMESCO Finland
Other operation on thyroid gland
83.7
22.7
25
*
G44.2
ICD-10 Finland
Tension-type headache
1.5
22.6
894
6272
A02BC04
ATC
rabeprazole; oral
1.6
22.1
567
3591
A02BA02
ATC
ranitidine; systemic
1.4
22.0
1385
10606
SPAT1325
SPAT
Vaccination
1.3
21.8
2418
20134
M01AE03
ATC
ketoprofen; systemic, rectal
1.3
21.7
2556
21457
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
21.6
2121
17365
19399
ICD-8 Finland
Malignant neoplasm of thyroid gland
220.5
21.6
22
*
A02BC03
ATC
lansoprazole; oral
1.3
21.5
2049
16704
N03AX12
ATC
gabapentin; oral
1.4
21.1
1020
7440
A12AA04
ATC
calcium carbonate; oral
3.3
21.1
109
337
M54.4
ICD-10 Finland
Lumbago with sciatica
1.4
21.1
1051
7716
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.5
20.9
764
5266
24599
ICD-8 Finland
Thyroiditis, Unspecified
+∞
20.8
20
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
20.7
1171
8789
E66.01
ICD-10 Finland
Obesity due to excess calories
1.7
20.7
423
2514
E20.9
ICD-10 Finland
Hypoparathyroidism, unspecified
25.5
20.4
28
11
R02
ICPC
Shortness of breath/dyspnoea
1.5
20.3
789
5508
GD6AD
NOMESCO Finland
CT of chest and neck
9.4
20.0
41
44
R01AD08
ATC
fluticasone; nasal
1.3
19.9
1772
14281
BA2AT
NOMESCO Finland
Biopsy of thyroid with ultrasound quidance
18.8
19.9
30
16
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
+∞
19.8
19
*
ZXE20
NOMESCO Finland
More than three and less than five hours
1.4
19.7
860
6148
M02AA07
ATC
piroxicam; topical
1.3
19.7
2666
22703
M25.5
ICD-10 Finland
Pain in joint
1.3
19.7
1852
15041
UKC02
NOMESCO Finland
Cystoscopy
1.4
19.5
862
6176
N03AX16
ATC
pregabalin; oral
1.3
19.5
1571
12468
SPAT1312
SPAT
General health counselling
1.3
19.5
2040
16799
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
19.4
1534
12142
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
19.1
2537
21524
R51.80
ICD-10 Finland
Headache
1.4
19.1
870
6268
A02BC01
ATC
omeprazole; systemic
1.3
18.6
1872
15314
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.2
18.5
2995
25991
SPAT1301
SPAT
No procedures
1.3
18.4
2115
17602
J01MA02
ATC
ciprofloxacin; systemic
1.3
18.4
2485
21105
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
1.6
18.2
441
2751
GAB20
NOMESCO Finland
Median sternotomy
32.9
17.9
23
7
E06.9
ICD-10 Finland
Thyroiditis, unspecified
15.3
17.9
29
19
J01FA09
ATC
clarithromycin; systemic
1.3
17.9
2039
16942
M01AC06
ATC
meloxicam; systemic, rectal
1.3
17.8
2612
22387
8340/3-C73.9
ICD-O-3
Papillary carcinoma, follicular variant of thyroid gland
+∞
17.7
17
*
WX704
NOMESCO Finland
Intubation
1.6
17.7
440
2766
R05
ICD-10 Finland
Cough
1.3
17.6
1275
9941
E03.8
ICD-10 Finland
Other specified hypothyroidism
95.3
17.5
19
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
17.5
1965
16293
AA1AD
NOMESCO Finland
CT of head and brain
1.3
17.5
1531
12279
H04.10
ICD-10 Finland
Dry eye syndrome
1.5
17.5
652
4509
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
17.4
2820
24422
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
17.4
1998
16612
A12AA06
ATC
calcium lactate gluconate; oral
16.9
17.3
27
16
J01CA04
ATC
amoxicillin; systemic
1.3
17.3
5512
51414
C07AB02
ATC
metoprolol; systemic
1.3
17.2
1398
11086
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.3
17.2
1590
12840
SAA01
NOMESCO Finland
Simple examination of mouth
1.2
17.2
4512
41164
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
17.1
3195
28091
SPAT1058
SPAT
PEF monitoring instruction
1.5
16.9
548
3679
C08CA01
ATC
amlodipine; oral
1.3
16.8
2410
20560
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
16.7
2115
17779
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
16.7
16
*
N06AX11
ATC
mirtazapine; oral
1.3
16.6
2026
16953
Z50.5
ICD-10 Finland
Speech therapy
3.0
16.5
93
308
M01AE02
ATC
naproxen; oral, rectal
1.2
16.5
3713
33255
SPAT1310
SPAT
Counselling related to known health issue
1.3
16.4
2065
17338
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.3
16.3
1467
11787
N06AX21
ATC
duloxetine; oral
1.5
16.2
642
4496
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.7
16.1
369
2267
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.3
16.1
1505
12163
R5140
NOMESCO Finland
Monitoring the use of the aid
1.5
16.0
525
3528
S04
ICPC
Lump/swelling localized
1.5
15.9
567
3883
R03AC03
ATC
terbutaline; inhalant
1.4
15.9
901
6748
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.4
15.9
730
5262
R4130
NOMESCO Finland
Speech therapy
2.4
15.8
138
592
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
15.7
1666
13676
EP2AT
NOMESCO Finland
Neck soft tissue cytology with ultrasound guidance
6.8
15.7
39
58
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
15.6
635
4469
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
15.6
1257
9939
XKD00
NOMESCO Finland
Uroflowmetry
1.5
15.6
590
4092
L01
ICPC
Neck symptom/complaint
1.4
15.5
864
6452
L17
ICPC
Foot/toe symptom/complaint
1.3
15.4
1668
13727
WZC30
NOMESCO Finland
Teaching
1.4
15.4
789
5806
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
1.3
15.2
1243
9847
E21.0
ICD-10 Finland
Primary hyperparathyroidism
2.4
15.2
125
521
J02AC01
ATC
fluconazole; systemic
1.2
15.1
2911
25565
T90
ICPC
Diabetes non-insulin dependent
1.3
15.1
1344
10777
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.3
15.1
1774
14746
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.3
15.1
1402
11308
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.3
15.0
1241
9845
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.2
14.9
4183
38137
M03BC51
ATC
orphenadrine, combinations; systemic
1.3
14.9
1778
14800
R06AE07
ATC
cetirizine; oral
1.2
14.6
2854
25080
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
+∞
14.6
14
*
1930A
ICD-9 Finland
Malignant neoplasm of thyroid gland[CARCINOMA PAPILLARE THYREOIDEAE]
+∞
14.6
14
*
24400
ICD-8 Finland
Myxoedema, (hypothyreosis) post therapiam
+∞
14.6
14
*
L15
ICPC
Knee symptom/complaint
1.3
14.6
1420
11518
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.2
14.5
2759
24164
C07AA05
ATC
propranolol; systemic
1.3
14.5
1140
8975
Z71.8
ICD-10 Finland
Other specified counselling
1.3
14.5
1421
11529
SPAT1260
SPAT
Consultation of another employee
1.3
14.5
1131
8896
WX110
NOMESCO Finland
Local anesthesy
1.2
14.5
4431
40684
ZXE00
NOMESCO Finland
One hour or less
1.2
14.4
2542
22098
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
14.2
1356
10967
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.5
14.2
454
3037
C09CA01
ATC
losartan; oral
1.3
14.1
1576
12997
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.4
14.1
863
6537
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
1.4
14.1
732
5394
R05FB02
ATC
cough suppressants and expectorants
1.2
14.0
2651
23190
T15
ICPC
THYROID LUMP/MASS
10.9
14.0
26
24
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.3
14.0
1352
10951
E66.8
ICD-10 Finland
Other obesity
1.7
13.9
266
1551
M54.6
ICD-10 Finland
Pain in thoracic spine
1.6
13.9
386
2492
R05
ICPC
Cough
1.3
13.9
1411
11500
I49.3
ICD-10 Finland
Ventricular premature depolarization
1.6
13.9
407
2666
R06AX27
ATC
desloratadine; oral
1.3
13.8
1578
13049
R00.2
ICD-10 Finland
Palpitations
1.5
13.7
437
2919
C03CA01
ATC
furosemide; systemic
1.2
13.7
1858
15673
T78.4
ICD-10 Finland
Allergy, unspecified
1.8
13.6
247
1418
E83.50
ICD-10 Finland
Hypercalcemia
2.7
13.6
94
356
M01AB05
ATC
diclofenac; systemic, rectal
1.2
13.6
4468
41179
N02AJ06
ATC
codeine and paracetamol; systemic
1.2
13.5
2263
19526
J01FF01
ATC
clindamycin; systemic
1.3
13.5
1634
13597
R03BA02
ATC
budesonide; inhalant
1.3
13.5
1088
8595
M79.1
ICD-10 Finland
Myalgia
1.4
13.4
762
5701
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
13.4
3428
30837
205
Kela drug reimbursment
Chronic hypertension
1.2
13.4
1834
15482
WZA90
NOMESCO Finland
Other doctors statement
1.3
13.4
1332
10820
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.5
13.4
497
3436
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.4
13.3
818
6198
R03BA05
ATC
fluticasone; inhalant
1.3
13.3
1099
8708
Z3231
NOMESCO Finland
Registered nurse
1.2
13.1
1692
14178
A01
ICPC
Pain general/multiple sites
1.5
13.1
491
3397
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
13.1
3982
36373
M01AX17
ATC
nimesulide; oral
1.2
13.1
1705
14303
GD1AD
NOMESCO Finland
Thorax CT examination
1.8
13.1
238
1368
L03
ICPC
Low back symptom/complaint
1.3
13.0
1538
12760
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.3
12.9
1172
9398
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
2.6
12.9
94
369
A01AB09
ATC
miconazole; local oral
1.4
12.8
620
4511
H02AB09
ATC
hydrocortisone; systemic
2.5
12.8
100
408
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
12.7
978
7668
Z3226
NOMESCO Finland
Physiotherapist
1.3
12.6
1157
9299
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.4
12.6
687
5105
JN5SN
NOMESCO Finland
NA
+∞
12.5
12
*
R03BA01
ATC
beclometasone; inhalant
1.3
12.5
886
6865
J01EA01
ATC
trimethoprim; systemic
1.2
12.5
1908
16277
J01FA15
ATC
telithromycin; oral
1.4
12.5
580
4189
Z01.7
ICD-10 Finland
Laboratory examination
1.4
12.5
655
4833
R31
ICD-10 Finland
Unspecified haematuria
1.5
12.4
451
3099
F45.8
ICD-10 Finland
Other somatoform disorders
1.6
12.4
341
2200
R52.9
ICD-10 Finland
Pain, unspecified
1.5
12.4
500
3516
XF404
NOMESCO Finland
Ambulatory ECG
1.4
12.3
555
3983
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
1.5
12.3
423
2874
M70.6
ICD-10 Finland
Trochanteric bursitis
1.3
12.3
925
7228
C10AA07
ATC
rosuvastatin; oral
1.2
12.3
1515
12618
M01AE01
ATC
ibuprofen; systemic, rectal
1.2
12.3
6273
60020
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.3
12.3
891
6928
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
1.5
12.2
399
2680
R20.2
ICD-10 Finland
Paraesthesia of skin
1.5
12.2
372
2459
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
1.5
12.2
366
2411
J31.0
ICD-10 Finland
Chronic rhinitis
1.5
12.2
424
2887
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
1.6
12.2
285
1765
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
2.7
12.2
80
293
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
1.8
12.1
217
1241
N05BA04
ATC
oxazepam; oral
1.2
12.1
1568
13128
M01AH05
ATC
etoricoxib; oral
1.2
12.1
3875
35445
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
15.9
12.1
19
12
R60.0
ICD-10 Finland
Localized oedema
1.4
12.1
692
5182
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
1.6
12.1
297
1866
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.3
12.0
804
6171
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
1.5
12.0
424
2897
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
12.0
2901
25869
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.5
11.9
459
3196
SPAT1097
SPAT
Recording of ECG
1.3
11.9
959
7565
24210
ICD-8 Finland
Thyrotoxicosis with or without goitre, Toxic nodular goitre
6.8
11.9
29
43
C09DA01
ATC
losartan and diuretics; oral
1.4
11.9
666
4970
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
11.8
1225
9989
B02AA02
ATC
tranexamic acid; systemic
1.3
11.8
961
7588
UDQ02
NOMESCO Finland
Direct laryngoscopy
3.3
11.8
58
177
M79.0
ICD-10 Finland
Rheumatism, unspecified
1.7
11.8
239
1424
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
1.3
11.8
754
5749
R06.5
ICD-10 Finland
Mouth breathing
1.5
11.8
393
2654
C05AA08
ATC
fluocortolone; rectal, topical
1.3
11.7
892
6978
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.3
11.7
937
7385
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.2
11.7
1831
15642
J20
ICD-10 Finland
Acute bronchitis
1.4
11.7
576
4204
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
1.4
11.7
527
3783
J45
ICD-10 Finland
Asthma
1.4
11.7
588
4307
J46
ICD-10 Finland
Status asthmaticus
1.9
11.7
179
975
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
1.3
11.7
935
7372
K30
ICD-10 Finland
Functional dyspepsia
1.4
11.6
651
4857
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.3
11.6
1317
10855
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
1.4
11.6
538
3881
R03BA08
ATC
ciclesonide; inhalant
1.4
11.6
487
3449
K80
ICPC
Cardiac arrhythmia NOS
1.4
11.6
467
3284
E06.0
ICD-10 Finland
Acute thyroiditis
22.9
11.5
16
7
P01AB01
ATC
metronidazole; oral, rectal
1.2
11.5
2675
23740
C09CA06
ATC
candesartan; oral
1.3
11.5
1350
11174
M01AH01
ATC
celecoxib; oral (coxibs)
1.3
11.5
1220
9976
24209
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffuse NUD
+∞
11.5
11
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.3
11.4
1344
11124
XF402
NOMESCO Finland
ECG with work load test
1.4
11.4
660
4954
R96
ICPC
Asthma
1.4
11.4
543
3941
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
1.4
11.3
459
3232
D25.9
ICD-10 Finland
Leiomyoma of uterus, unspecified
1.4
11.3
611
4537
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.2
11.2
3217
29071
R49.8
ICD-10 Finland
Other and unspecified voice disturbances
2.6
11.2
79
305
Z01.2
ICD-10 Finland
Dental examination
1.2
11.2
2450
21615
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.3
11.2
720
5494
R04.2
ICD-10 Finland
Haemoptysis
1.9
11.2
169
917
A07AA02
ATC
nystatin; oral
1.5
11.2
409
2819
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.3
11.1
769
5933
EP1CG
NOMESCO Finland
Extensive MRI examination of soft tissue of neck with high intesity magnet
2.7
11.1
74
275
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.3
11.1
750
5767
C08CA13
ATC
lercanidipine; oral
1.3
11.0
855
6704
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
1.7
11.0
219
1298
A10BA02
ATC
metformin; oral
1.2
11.0
1594
13501
M53.1
ICD-10 Finland
Cervicobrachial syndrome
1.4
11.0
617
4606
B01AA03
ATC
warfarin; systemic
1.3
10.9
1143
9323
D11.0
ICD-10 Finland
Benign neoplasm: Parotid gland
2.2
10.9
107
490
A03FA02
ATC
cisapride; oral, rectal
1.4
10.8
504
3639
BBA20
NOMESCO Finland
Exploration of parathyroid gland
4.7
10.8
35
74
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
1.3
10.8
728
5594
D17.1
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of trunk
1.8
10.8
185
1048
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.2
10.7
1614
13718
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
21.5
10.7
15
7
R03AK07
ATC
formoterol and budesonide; inhalant
1.3
10.7
1089
8855
F51.0
ICD-10 Finland
Nonorganic insomnia
1.3
10.6
687
5243
A06AD11
ATC
lactulose; oral
1.3
10.6
855
6741
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
1.6
10.6
254
1587
Z09.0
ICD-10 Finland
Follow-up examination after surgery for other conditions
1.4
10.6
572
4244
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.3
10.6
923
7356
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.3
10.6
966
7744
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.4
10.5
622
4681
M01AH02
ATC
rofecoxib; oral
1.3
10.4
901
7170
A04
ICPC
Weakness/tiredness general
1.3
10.4
752
5834
L28
ICPC
Limited function/disability (L)
1.3
10.4
1013
8185
E06.5
ICD-10 Finland
Other chronic thyroiditis
+∞
10.4
10
*
8290/3-C73.9
ICD-O-3
Oxyphilic adenocarcinoma of thyroid gland
+∞
10.4
10
*
UDC00
NOMESCO Finland
Ear microscopy
1.5
10.4
398
2770
WX725
NOMESCO Finland
Noninvasive ventilation
1.6
10.4
258
1627
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
1.4
10.3
481
3474
QX3LT
NOMESCO Finland
Subcutaneous sclerotherapy
12.0
10.3
18
15
207
Kela drug reimbursment
Chronic arrhythmias
1.3
10.3
869
6892
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.4
10.3
624
4717
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.3
10.3
868
6889
A98
ICPC
Health maint/preventive medicine
1.3
10.2
7044
68613
21899
ICD-8 Finland
Uterine fibroma
1.5
10.2
396
2762
R03BB04
ATC
tiotropium bromide; inhalant
1.4
10.2
524
3851
H60.9
ICD-10 Finland
Otitis externa, unspecified
1.5
10.2
323
2157
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.4
10.2
598
4496
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
1.6
10.2
245
1530
R01AD01
ATC
beclometasone; nasal
1.3
10.2
911
7280
EP1AE
SPAT
NA
2.6
10.2
72
277
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.4
10.2
579
4333
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.3
10.2
1175
9693
H01
ICPC
Ear pain/earache
1.4
10.2
568
4237
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
1.3
10.2
642
4885
H93.1
ICD-10 Finland
Tinnitus
1.5
10.1
365
2512
L02
ICPC
Back symptom/complaint
1.4
10.1
508
3726
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
1.4
10.0
461
3329
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
2.5
9.9
75
303
E07.89
ICD-10 Finland
Other specified disorders of thyroid
16.7
9.9
15
9
J01DA06
ATC
[U] cefuroxime; systemic
1.3
9.8
869
6931
R12
ICD-10 Finland
Heartburn
1.4
9.8
409
2892
G04CA02
ATC
tamsulosin; oral
1.3
9.8
634
4839
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.3
9.8
828
6566
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
1.6
9.8
277
1805
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.4
9.8
557
4167
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
1.4
9.7
449
3238
D21
ICPC
Swallowing problem
2.3
9.7
83
357
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.5
9.7
308
2061
BA3AT
SPAT
NA
13.4
9.6
16
12
E03.1
ICD-10 Finland
Congenital hypothyroidism without goitre
55.0
9.6
11
*
E66.00
ICD-10 Finland
Metabolic syndrome
1.6
9.6
256
1644
M48.0
ICD-10 Finland
Spinal stenosis
1.3
9.6
771
6077
N06AX16
ATC
venlafaxine; oral
1.3
9.6
706
5495
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.3
9.5
673
5210
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.2
9.5
3426
31398
R11
ICD-10 Finland
Nausea and vomiting
1.4
9.5
462
3369
S29
ICPC
Skin symptom/complaint other
1.3
9.4
1022
8361
N40
ICD-10 Finland
Hyperplasia of prostate
1.4
9.4
550
4134
R51.81
ICD-10 Finland
Facial pain NOS
1.9
9.4
137
738
24200
ICD-8 Finland
Thyrotoxicosis with or without goitre, Cum struma diffusa et exophthalmo. Morbus Basedowi
+∞
9.4
9
*
H062, E050
ICD-10 Finland
NA
+∞
9.4
9
*
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.3
9.3
612
4685
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.3
9.3
578
4387
G04CB01
ATC
finasteride; oral (testosterone-5-alpha reductase inhibitors)
1.5
9.3
280
1852
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.4
9.3
414
2973
R07.3
ICD-10 Finland
Other chest pain
1.4
9.3
541
4066
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.3
9.2
773
6123
R49.03
ICD-10 Finland
Atrophic dysphonia
2.5
9.2
70
283
M47.9
ICD-10 Finland
Spondylosis, unspecified
1.7
9.2
192
1158
C10AA05
ATC
atorvastatin; oral
1.2
9.2
2381
21227
N06AA09
ATC
amitriptyline; systemic
1.3
9.2
644
4974
UJF30
NOMESCO Finland
Ileoscopy through colon
1.4
9.2
537
4035
C03DA01
ATC
spironolactone; oral
1.3
9.1
609
4673
L16
ICPC
Ankle symptom/complaint
1.3
9.1
575
4377
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.4
9.1
452
3308
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.3
9.1
691
5406
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
1.6
9.1
220
1380
103
Kela drug reimbursment
Diabetes, insulin-treated
1.2
9.1
1469
12554
N39.3
ICD-10 Finland
Stress incontinence
1.3
9.0
547
4140
R49.0
ICD-10 Finland
Dysphonia
2.1
9.0
101
493
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.4
9.0
465
3426
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
1.4
8.9
442
3229
R60.9
ICD-10 Finland
Oedema, unspecified
1.5
8.9
279
1861
M01AX05
ATC
glucosamine; oral
1.2
8.9
1535
13192
E07
ICD-10 Finland
Other disorders of thyroid
24.0
8.9
12
5
J38.4
ICD-10 Finland
Oedema of larynx
3.3
8.9
43
132
M79.7
ICD-10 Finland
Fibromyalgia
1.7
8.9
190
1151
R23
ICPC
Voice symptom/complaint
1.9
8.9
126
672
R74
ICPC
Upper respiratory infection acute
1.2
8.9
1488
12755
H60.3
ICD-10 Finland
Other infective otitis externa
2.0
8.9
112
574
K59.09
ICD-10 Finland
Constipation, unspecified
1.5
8.8
337
2347
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
1.8
8.8
149
841
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.2
8.8
1188
9957
SPAT1211
SPAT
Application of soft bandage
1.4
8.8
520
3915
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.2
8.8
1621
14016
I84.2
ICD-10 Finland
Internal hemorrhoids without complication
1.4
8.8
464
3427
D01
ICPC
Abdominal pain/cramps general
1.3
8.8
589
4519
A01AB04
ATC
amphotericin B; local oral
1.5
8.8
326
2257
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.2
8.8
1450
12409
J45.1
ICD-10 Finland
Nonallergic asthma
1.4
8.8
395
2841
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.4
8.7
368
2614
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.3
8.7
754
5998
A02BA04
ATC
nizatidine; systemic
1.4
8.7
488
3642
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
1.5
8.7
254
1670
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
1.8
8.7
138
765
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.3
8.7
516
3892
G04BD04
ATC
oxybutynin; oral, transdermal
1.4
8.6
368
2617
R03AC13
ATC
formoterol; inhalant
1.5
8.6
289
1959
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
2.3
8.6
73
315
J38.7
ICD-10 Finland
Other diseases of larynx
3.6
8.6
37
104
D25.1
ICD-10 Finland
Intramural leiomyoma of uterus
1.4
8.5
394
2847
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
1.5
8.5
282
1908
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
1.6
8.5
219
1395
R52.2
ICD-10 Finland
Other chronic pain
1.7
8.5
178
1076
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
2.3
8.5
75
330
K02.1
ICD-10 Finland
Caries of dentine
1.2
8.5
3268
30003
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
2.4
8.4
71
302
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.3
8.4
612
4755
N83.2
ICD-10 Finland
Other and unspecified ovarian cysts
1.3
8.4
637
4977
E03.3
ICD-10 Finland
Postinfectious hypothyroidism
90.1
8.4
9
*
D17.2
ICD-10 Finland
Benign lipomatous neoplasm of skin and subcutaneous tissue of limbs
1.9
8.4
124
670
45499
ICD-8 Finland
Varicose veins of lower extremities, Other and unspecified, without ulcer
1.3
8.4
532
4053
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.3
8.3
770
6175
BA1AQ
NOMESCO Finland
Thyroid SPECT with low dose CT
+∞
8.3
8
*
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
+∞
8.3
8
*
2449X
ICD-9 Finland
Acquired hypothyroidism, Unspecified hypothyroidism
+∞
8.3
8
*
E03.4
ICD-10 Finland
Atrophy of thyroid (acquired)
+∞
8.3
8
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.4
8.3
337
2375
B01AF02
ATC
apixaban; oral
1.3
8.3
572
4410
M54
ICD-10 Finland
Dorsalgia
1.3
8.3
606
4713
D24
ICD-10 Finland
Benign neoplasm of breast
1.8
8.3
137
773
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.2
8.2
984
8139
SPAT1043
SPAT
Audiometry
1.3
8.2
630
4928
J35.0
ICD-10 Finland
Chronic tonsillitis
1.6
8.2
200
1261
UGC12
NOMESCO Finland
Flexible bronchoscopy
1.4
8.2
389
2825
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
2.0
8.2
97
484
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.3
8.2
567
4378
A10BK03
ATC
empagliflozin; oral
1.4
8.1
319
2235
SPAT1336
SPAT
Request for examination
1.6
8.1
215
1382
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
1.4
8.1
461
3451
J34.2
ICD-10 Finland
Deviated nasal septum
1.6
8.1
195
1223
SPAT1212
SPAT
Extensive examination of musculoskeletal system
1.4
8.0
471
3542
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.2
8.0
2364
21241
-
ICD-10 Finland
NA
1.8
8.0
142
817
R09
ICPC
Sinus symptom/complaint
1.4
8.0
416
3067
R06AE09
ATC
levocetirizine; oral
1.3
8.0
788
6376
C01BC04
ATC
flecainide; systemic
1.6
8.0
191
1200
N64.4
ICD-10 Finland
Mastodynia
1.7
7.9
157
934
X59
ICD-10 Finland
Exposure to unspecified factor
1.2
7.9
969
8040
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
1.9
7.9
108
572
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
1.3
7.8
535
4120
R49.09
ICD-10 Finland
Unspecified dysphonia
2.3
7.8
70
308
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
1.4
7.8
368
2668
D18.0
ICD-10 Finland
Haemangioma, any site
1.8
7.8
125
694
A77
ICPC
Viral disease other/NOS
1.7
7.8
147
862
K59.0
ICD-10 Finland
Constipation
1.4
7.8
309
2172
M01AG02
ATC
tolfenamic acid; oral, rectal
1.2
7.8
955
7924
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
1.6
7.8
200
1278
J38.3
ICD-10 Finland
Other diseases of vocal cords
2.5
7.7
57
227
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.2
7.7
913
7542
SPAT1262
SPAT
Handing over of treatment supplies
1.2
7.7
989
8241
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.3
7.7
697
5574
C739
ICD-10 Finland
NA
45.0
7.7
9
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.3
7.7
792
6438
TDM10
NOMESCO Finland
Puncture of maxillary antrum
1.6
7.7
193
1227
ZXD20
NOMESCO Finland
Day surgery
1.3
7.6
772
6263
N01
ICPC
Headache
1.3
7.6
471
3573
F29
ICPC
Eye symptom/complaint other
1.3
7.6
454
3423
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
2.9
7.6
44
152
D06
ICPC
Abdominal pain localized other
1.3
7.6
450
3392
H57.1
ICD-10 Finland
Ocular pain
1.7
7.6
162
984
RL210
NOMESCO Finland
NA
3.3
7.6
35
105
R29
ICPC
Respiratory symptom/complaint other
1.4
7.6
316
2244
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.2
7.5
1193
10155
TPH07
NOMESCO Finland
Cathetrisation of artery
1.3
7.5
556
4329
P06
ICPC
Sleep disturbance
1.3
7.5
472
3592
EMB10
NOMESCO Finland
Tonsillectomy
1.6
7.5
191
1218
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.4
7.5
348
2517
M01AC01
ATC
piroxicam; systemic, rectal
1.2
7.5
837
6868
XA402
NOMESCO Finland
ENMG
1.7
7.5
135
783
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.1
7.4
2694
24554
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
1.3
7.4
699
5624
WX723
NOMESCO Finland
CPAP therapy
1.7
7.4
141
831
N30.0
ICD-10 Finland
Acute cystitis
1.2
7.4
953
7950
L08
ICPC
Shoulder symptom/complaint
1.2
7.3
1136
9648
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
3.1
7.3
37
119
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
1.6
7.3
181
1148
SPAT1285
SPAT
Provision of consultation response
1.4
7.3
298
2105
H02AB04
ATC
methylprednisolone; systemic
1.2
7.3
881
7291
Z2221
NOMESCO Finland
Medical doctor
1.2
7.3
1696
14937
24509
ICD-8 Finland
Thyroiditis, Unspecified
+∞
7.3
7
*
M14.5*E03.9
ICD-10 Finland
Arthropathy in hypothyroidism (E00-E03+)
+∞
7.3
7
*
E8901, C7391
ICD-10 Finland
NA
+∞
7.3
7
*
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.2
7.3
969
8107
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
2.0
7.2
88
446
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
1.5
7.2
202
1317
M47.82
ICD-10 Finland
Other spondylosis, cervical region
1.5
7.2
223
1488
H13
ICPC
Plugged feeling ear
1.2
7.2
1035
8722
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
1.3
7.2
601
4763
L86
ICPC
Back syndrome with radiating pain
1.4
7.2
323
2326
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.3
7.2
650
5202
U07
ICPC
Urine symptom/complaint other
1.4
7.2
334
2421
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
4.6
7.2
23
50
6481B
ICD-9 Finland
Other current conditions in the mother classifiable elsewhere but complicating pregnancy, childbirth and the puerperium, Thyroid dysfunction[HYPOTHYREOSIS IN GRAVIDITATE]
30.0
7.1
9
*
K11.2
ICD-10 Finland
Sialoadenitis
1.6
7.1
166
1035
R4110
NOMESCO Finland
Physiotherapy
1.2
7.1
1626
14298
SDA02
NOMESCO Finland
Parodonthologic therapy
1.2
7.1
1921
17121
H53.1
ICD-10 Finland
Subjective visual disturbances
1.4
7.1
343
2504
E21.2
ICD-10 Finland
Other hyperparathyroidism
3.2
7.1
34
106
L82
ICD-10 Finland
Seborrhoeic keratosis
1.2
7.0
1000
8422
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.2
7.0
965
8097
K21
ICD-10 Finland
Gastro-oesophageal reflux disease
1.4
7.0
266
1858
SPAT1216
SPAT
Assessment of functional ability
1.2
7.0
967
8120
N05CF01
ATC
zopiclone; oral
1.2
7.0
2077
18639
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
1.4
6.9
321
2324
S82
ICPC
Naevus/mole
1.3
6.9
683
5523
RP210
NOMESCO Finland
NA
5.1
6.9
20
39
E06
ICD-10 Finland
Thyroiditis
13.8
6.9
11
8
23914
ICD-8 Finland
Neoplasm of unspecified nature of other and unspecified organs, Glandulae thyreoideae
13.8
6.9
11
8
R35
ICD-10 Finland
Polyuria
1.4
6.9
281
1991
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.1
6.9
2349
21290
L02.2
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of trunk
1.6
6.8
182
1177
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.2
6.8
1416
12345
A11
ICPC
Chest pain NOS
1.3
6.8
442
3383
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.3
6.8
645
5194
-34
ICPC
Blood test
1.6
6.8
151
933
J01
ICD-10 Finland
Acute sinusitis
1.5
6.8
250
1738
2502
FHL
Thyroid exploration and possible biopsy
40.0
6.8
8
*
SPAT1254
SPAT
Administration of medicine
1.2
6.7
824
6833
N17
ICPC
Vertigo/dizziness
1.3
6.7
681
5528
XQ800
NOMESCO Finland
Prick test
1.4
6.7
363
2701
N05CF02
ATC
zolpidem; oral
1.2
6.7
1036
8801
2509
FHL
Other measure in this category
22.5
6.7
9
*
WX722
NOMESCO Finland
PEEP
1.5
6.6
197
1306
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.2
6.6
960
8097
JHB30
NOMESCO Finland
Rubber band ligature of haemorrhoids or prolapse of mucosa
1.4
6.6
327
2395
A10BH01
ATC
sitagliptin; oral
1.3
6.6
488
3803
M01AX01
ATC
nabumetone; oral
1.4
6.6
269
1903
EP1DG
NOMESCO Finland
Very extensive examination of soft tissue of neck with high intesity magnet
2.8
6.6
39
140
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.1
6.6
2553
23328
QX4AT
NOMESCO Finland
Ultrsound guided needle biopsy of skin
3.2
6.5
31
96
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
1.4
6.5
307
2228
R03AK08
ATC
formoterol and beclometasone; inhalant
1.5
6.5
197
1310
DQE20
NOMESCO Finland
Implantation of foreign material in vocal chord
10.0
6.5
12
12
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
1.3
6.5
627
5056
A99
ICPC
Disease/condition unspecnature/site
1.3
6.5
430
3303
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.3
6.5
408
3111
L90
ICPC
Osteoarthrosis of knee
1.3
6.4
401
3051
C09CA03
ATC
valsartan; oral
1.3
6.4
480
3747
J01CA08
ATC
pivmecillinam; oral
1.1
6.4
3227
29967
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.2
6.4
1447
12700
SPAT1104
SPAT
Monitoring of emergency patient
1.4
6.4
359
2686
A60
ICPC
General and Unspecified, Result test/procedure
1.5
6.4
235
1631
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
2.3
6.4
53
230
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.3
6.4
514
4058
R06.4
ICD-10 Finland
Hyperventilation
1.9
6.4
83
433
N06AB04
ATC
citalopram; systemic
1.2
6.4
1274
11074
L12
ICPC
Hand/finger symptom/complaint
1.2
6.4
779
6460
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
1.6
6.3
159
1013
E22.0
ICD-10 Finland
Acromegaly and pituitary gigantism
8.1
6.3
13
16
L91.0
ICD-10 Finland
Hypertrophic scar
2.1
6.3
65
310
A05
ICPC
Feeling ill
1.4
6.3
238
1662
N30
ICD-10 Finland
Cystitis
1.3
6.3
461
3592
K07.60
ICD-10 Finland
Snapping jaw
1.4
6.3
238
1663
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.2
6.3
1146
9877
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.2
6.3
832
6959
Z25.1
ICD-10 Finland
Need for immunization against influenza
1.4
6.3
288
2088
24191
ICD-8 Finland
NA
+∞
6.2
6
*
24503
ICD-8 Finland
Thyroiditis, Chronica
+∞
6.2
6
*
E042, D440
ICD-10 Finland
NA
+∞
6.2
6
*
E01.0
ICD-10 Finland
Iodine-deficiency-related diffuse (endemic) goitre
+∞
6.2
6
*
BA1AN
NOMESCO Finland
Thyroid gland isotope imaging
+∞
6.2
6
*
M65.3
ICD-10 Finland
Trigger finger
1.5
6.2
223
1539
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
1.5
6.2
213
1459
2180A
ICD-9 Finland
Uterine leiomyoma, Submucous leiomyoma of uterus
1.3
6.2
451
3506
R04
ICPC
Breathing problem other
1.6
6.2
166
1076
SPAT1044
SPAT
Tympanometry
1.8
6.2
105
599
ZX120
NOMESCO Finland
Intravenous
1.3
6.2
503
3973
SAA03
NOMESCO Finland
Extended examination of mouth
1.1
6.2
2154
19517
BB1BQ
NOMESCO Finland
Extensive scintigraphy of parathyroid gland, 2 isotopes, SPECT and low-dose CT
3.1
6.2
31
101
UJC01
NOMESCO Finland
Scopy of lower throat
2.4
6.1
47
193
R03AC12
ATC
salmeterol; inhalant
1.4
6.1
246
1736
A10BH05
ATC
linagliptin; oral
1.4
6.1
239
1680
SFA00
NOMESCO Finland
Small filling
1.2
6.1
677
5552
R01AD05
ATC
budesonide; nasal
1.3
6.1
438
3402
S21
ICPC
Skin texture symptom/complaint
1.2
6.1
716
5907
D12
ICPC
Constipation
1.5
6.1
174
1144
R00.0
ICD-10 Finland
Tachycardia, unspecified
1.5
6.1
201
1363
N04BC05
ATC
pramipexole; oral
1.3
6.1
434
3366
S01GX01
ATC
cromoglicic acid; ophthalmic
1.2
6.1
1151
9948
K86
ICPC
Hypertension uncomplicated
1.2
6.1
737
6099
J39.2
ICD-10 Finland
Other diseases of pharynx
2.2
6.1
56
254
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
1.6
6.1
129
788
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
1.3
6.1
432
3352
SPAT1377
SPAT
Polysomnography
1.6
6.1
145
913
M54.2
ICD-10 Finland
Cervicalgia
1.3
6.1
357
2693
SPAT1257
SPAT
Teaching of medicine inhalation technique
1.5
6.0
197
1336
2260A
ICD-9 Finland
Benign neoplasm of thyroid gland[NEOPLASMA BENIGNUM GLANDULAE THYREOIDEAE]
4.4
6.0
20
46
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
1.3
6.0
548
4393
Mortality – FinRegistry
↥Association
Association between endpoint E4_GOITREMULTINOD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITREMULTINOD | 0.943 [0.87, 1.02] | 0.167 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 3745 out of 27526 females with E4_GOITREMULTINOD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GOITREMULTINOD | 0.966 [0.87, 1.07] | 0.519 |
| Birth year | 0.987 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 982 out of 5001 males with E4_GOITREMULTINOD died.
Mortality risk
Mortality risk for people of age
years, who have E4_GOITREMULTINOD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.095% | 0.187% |
| 5 | 0.505% | 1.23% |
| 10 | 1.242% | 2.97% |
| 15 | 2.22% | 5.37% |
| 20 | 4.119% | 8.844% |
Relationships between endpoints
↥Index endpoint: E4_GOITREMULTINOD – Nontoxic multinodular goitre
GWS hits: 55
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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