No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
9374 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
4422 |
6. Filter based on genotype QC (FinnGen only) |
4247 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Graves disease, strict definition
based on the number of shared cases.
Similar with more cases:
- Carbimazole or st.post thyroidectomy, condition for graves disease
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23064 | 18836 | 4057 |
| Only index persons | 22484 | 18513 | 3971 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.46 | 0.54 | 0.11 |
| Only index persons | 0.59 | 0.68 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 49.31 | 49.21 | 50.36 |
| Only index persons | 49.26 | 49.12 | 49.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4247 | 3592 | 655 |
| Unadjusted period prevalence (%) | 1.12 | 1.27 | 0.30 |
| Median age at first event (years) | 50.19 | 49.46 | 54.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 4422
- Matched controls
- 44220
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H03AA01
ATC
levothyroxine sodium; systemic
12.5
307.7
3198
7649
H03BB01
ATC
carbimazole; oral
4013.3
307.7
4326
491
C07AA05
ATC
propranolol; systemic
5.3
307.7
2125
6601
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
100.9
307.7
863
106
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
60.9
307.7
560
105
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
325.3
307.7
592
21
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
33.4
307.7
454
151
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
14.7
307.7
386
286
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
32.0
307.7
392
134
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
37.2
307.7
884
295
T85
ICPC
Hyperthyroidism/thyrotoxicosis
47.1
307.7
295
67
BAA60
NOMESCO Finland
Total thyroidectomy
47.2
307.7
1353
409
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
19726.5
307.7
4365
171
104
Kela drug reimbursment
Thyroid insufficiency
9.4
307.7
1204
1687
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
115.7
307.7
2138
355
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
35.6
251.4
158
46
C07AB07
ATC
bisoprolol; oral
2.8
246.5
2331
12518
E05.89
ICD-10 Finland
Other thyrotoxicosis
55.0
217.0
123
23
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.6
199.8
515
1228
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
15.5
193.7
170
114
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
45.5
188.2
111
25
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
28.6
186.0
125
45
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
7.3
175.7
266
385
T86
ICPC
Hypothyroidism/myxoedema
4.6
168.1
426
998
H062, E050,
ICD-10 Finland
346.0
167.3
168
5
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
288.6
163.8
166
6
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
156.9
1769
9753
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
19.1
151.1
119
64
H03BA02
ATC
propylthiouracil; oral
65.0
150.8
83
13
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.6
147.8
377
886
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
127.5
2168
13786
H05.2
ICD-10 Finland
Exophthalmic conditions
35.1
120.6
76
22
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.5
115.3
847
3779
CA1AD
NOMESCO Finland
Orbita CT
29.1
98.9
66
23
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
10.2
94.0
106
106
E03
ICD-10 Finland
Other hypothyroidism
3.0
93.3
455
1635
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
19.8
93.1
72
37
A11CC03
ATC
alfacalcidol; systemic
5.5
78.3
155
292
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
5.5
71.4
141
265
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.5
69.5
135
250
E05.5
ICD-10 Finland
Thyroid crisis or storm
115.1
63.0
68
6
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
21.1
61.1
46
22
E83.51
ICD-10 Finland
Hypocalcemia
8.7
58.6
74
86
106
Kela drug reimbursment
Hypoparathyroidism
10.8
55.7
60
56
E06.3
ICD-10 Finland
Autoimmune thyroiditis
7.0
55.0
84
122
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.0
52.4
235
800
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.8
45.7
246
925
H50.2
ICD-10 Finland
Vertical strabismus
6.7
43.7
69
104
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
4.4
41.6
106
247
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
68.8
36.0
41
6
H53.2
ICD-10 Finland
Diplopia
2.9
34.4
163
572
ZXA10
NOMESCO Finland
Bilateral
1.7
34.3
726
4573
R00.2
ICD-10 Finland
Palpitations
2.0
33.4
409
2178
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
32.9
547
3214
XCK00
NOMESCO Finland
Perimetry
2.3
32.9
258
1158
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
166.2
31.7
33
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.9
31.3
415
2268
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
30.7
703
4510
A11CC02
ATC
dihydrotachysterol; oral
11.1
29.3
31
28
WX402
NOMESCO Finland
General anaesthesia
1.6
29.2
911
6289
C07AB02
ATC
metoprolol; systemic
1.7
28.2
642
4105
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
27.9
1037
7427
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.8
27.6
142
522
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
26.6
27.0
37
14
ZXE10
NOMESCO Finland
More than one and less than three hours
1.4
26.7
1406
10776
CEC00
NOMESCO Finland
Recession of extraocular muscle
7.6
25.5
36
48
CAC44
NOMESCO Finland
Combined decompression of orbit
87.2
23.7
26
*
CAC20
NOMESCO Finland
Lateral decompression of orbit
241.3
23.7
24
*
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
23.7
23.4
33
14
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
3.6
23.4
77
217
E06.9
ICD-10 Finland
Thyroiditis, unspecified
6.4
23.1
38
60
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
4.1
22.6
61
149
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
22.0
860
6187
H02AB06
ATC
prednisolone; systemic
1.4
21.4
1880
15561
E07.9
ICD-10 Finland
Disorder of thyroid, unspecified
6.6
21.3
34
52
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
21.2
479
3044
2AB04, ,
NOMESCO Finland
8.5
21.0
27
32
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
211.0
20.6
21
*
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
2.6
20.5
117
454
H50.6
ICD-10 Finland
Mechanical strabismus
29.0
19.6
26
9
XCD10
NOMESCO Finland
Electrophysiological examination of eye
2.8
19.2
97
354
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
4.9
19.0
41
84
K04
ICPC
Palpitations/awareness of heart
1.9
18.9
224
1178
WF099
NOMESCO Finland
Other radiotherapy
5.5
18.8
36
66
K90.0
ICD-10 Finland
Coeliac disease
2.3
18.0
135
595
ZX120
NOMESCO Finland
Intravenous
1.7
17.7
343
2092
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
20.9
17.3
25
12
H50.8
ICD-10 Finland
Other specified strabismus
14.8
17.1
28
19
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.3
17.1
1531
12584
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.0
16.2
166
830
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
12.9
15.6
27
21
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
15.6
15
*
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.0
15.6
164
828
H02AB07
ATC
prednisone; oral
1.5
15.0
504
3495
E05.81
ICD-10 Finland
Overproduction of thyroid-stimulating hormone
56.9
14.8
17
*
N02BE01
ATC
paracetamol; systemic, rectal
1.4
14.5
3757
35387
CA1BD
NOMESCO Finland
Extensive orbita CT
22.3
14.2
20
9
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
12.7
13.9
24
19
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
75.4
13.6
15
*
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
13.5
1431
11937
K80
ICPC
Cardiac arrhythmia NOS
1.6
13.1
284
1785
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.8
12.8
210
1223
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
70.1
12.6
14
*
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
70.1
12.6
14
*
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
130.4
12.4
13
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
3.6
12.4
40
112
E06.1
ICD-10 Finland
Subacute thyroiditis
3.4
12.3
43
127
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
2.1
11.8
113
552
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
11.7
11.8
21
18
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
15.1
11.3
18
12
E89.1
ICD-10 Finland
Postprocedural hypoinsulinaemia
20.1
11.1
16
8
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
11.1
726
5646
A04
ICPC
Weakness/tiredness general
1.4
10.9
531
3940
H04AA01
ATC
glucagon; nasal, parenteral
2.2
10.8
93
436
WX110
NOMESCO Finland
Infiltration anesthesia
1.3
10.8
2989
27613
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
10.8
651
4998
T89
ICPC
Diabetes insulin dependent
1.9
10.5
140
767
TFP20
NOMESCO Finland
Cardiodefibrillation
1.8
10.3
159
912
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
2.2
10.2
81
369
N07BA03
ATC
varenicline; oral
1.7
10.1
184
1107
CS494
NOMESCO Finland
Other visual field testing
2.2
10.0
85
397
XCK10
NOMESCO Finland
Photography of fundus of eye
1.5
10.0
270
1786
SPAT1097
SPAT
Recording of ECG
1.4
9.8
424
3081
A02BC02
ATC
pantoprazole; systemic
1.2
9.4
2647
24292
O992, E050,
ICD-10 Finland
+∞
9.4
9
*
E20.8
ICD-10 Finland
Other hypoparathyroidism
21.7
9.3
13
6
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
1.5
9.2
279
1892
SPAT1249
SPAT
Treatment-related counselling outside office
1.2
9.2
1512
13140
CKC12
NOMESCO Finland
Photocoagulation of retina
1.8
9.1
124
686
CBK99
NOMESCO Finland
Other operation for retraction of eyelid
36.8
9.0
11
*
BA1AE, ,
SPAT
2.4
8.9
58
242
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
2.9
8.9
39
133
E03.4
ICD-10 Finland
Atrophy of thyroid (acquired)
24.0
8.9
12
5
CEW99
NOMESCO Finland
Other operation on extraocular muscle
12.5
8.9
15
12
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
3.0
8.8
37
123
R53
ICD-10 Finland
Malaise and fatigue
1.3
8.8
903
7437
R63.4
ICD-10 Finland
Abnormal weight loss
1.9
8.8
114
621
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.6
8.8
196
1242
M14.5*E05.9
ICD-10 Finland
Arthropathy in thyrotoxicosis [hyperthyroidism]
50.1
8.7
10
*
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.3
8.6
779
6315
E07.89
ICD-10 Finland
Other specified disorders of thyroid
9.0
8.5
17
19
E10
ICD-10 Finland
Type 1 diabetes mellitus
2.1
8.4
73
345
207
Kela drug reimbursment
Chronic arrhythmias
1.4
8.3
320
2276
A60
ICPC
General and Unspecified, Result test/procedure
1.7
8.3
149
893
R25.1
ICD-10 Finland
Tremor, unspecified
1.9
8.2
93
486
H50.52
ICD-10 Finland
Exophoria
2.4
8.1
51
210
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
1.5
8.1
211
1388
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.4
8.0
448
3396
ZYC06
NOMESCO Finland
Real-time text-based remote transaction
4.4
7.9
19
43
H3601, E103,
ICD-10 Finland
3.0
7.8
33
111
R49.08
ICD-10 Finland
Other specified dysphonia
1.9
7.7
86
446
A10AE05
ATC
insulin detemir; parenteral
1.6
7.7
156
967
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
3.2
7.7
29
91
A12AA04
ATC
calcium carbonate; oral
2.6
7.6
42
163
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
1.6
7.6
190
1240
A10AB05
ATC
insulin aspart; parenteral
1.5
7.6
215
1442
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
6.2
7.5
19
31
N05CF01
ATC
zopiclone; oral
1.2
7.5
1095
9361
R06.0
ICD-10 Finland
Dyspnoea
1.2
7.3
866
7237
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
8.4
7.3
15
18
A10AE04
ATC
insulin glargine; parenteral
1.5
7.3
251
1751
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.2
7.2
1054
9002
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
7.2
325
2378
XCH00
NOMESCO Finland
Eye pressure measurement
1.7
7.2
133
805
Z3231
NOMESCO Finland
Registered nurse
1.2
7.2
906
7621
K02.1
ICD-10 Finland
Caries of dentine
1.2
7.2
2422
22331
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
3.0
7.2
30
100
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.2
6.9
2236
20511
A10AB01
ATC
insulin (human); parenteral
1.7
6.8
111
651
ZXE00
NOMESCO Finland
One hour or less
1.2
6.7
1452
12861
O90.5
ICD-10 Finland
Postpartum thyroiditis
12.2
6.6
11
9
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.3
6.5
616
5013
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
1.9
6.5
75
396
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
1.3
6.4
383
2932
CBB21
NOMESCO Finland
Correction of lax skin and resection of herniated fat in upper eyelid
3.0
6.4
27
91
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
2.4
6.4
41
172
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
6.3
288
2117
A99
ICPC
Disease/condition unspecnature/site
1.4
6.3
292
2152
E8901, E050,
ICD-10 Finland
+∞
6.2
6
*
C07AA07
ATC
sotalol; systemic
1.9
6.2
75
401
A10AB04
ATC
insulin lispro; parenteral
1.7
6.1
104
619
Z50.5
ICD-10 Finland
Speech therapy
2.3
6.0
43
189
Z01.8
ICD-10 Finland
Other specified special examinations
1.2
6.0
784
6608
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
4301
30851
15.40
307.65
16.0
4.1
15.52
14.53
pmol/l
112.89
4187
28647
1448
3295
6.05
307.65
1.4
1.2
232.80
149.90
iu/ml
7.23
804
1233
2863
2598
29.42
307.65
8.3
2.7
4.88
4.45
pmol/l
30.43
2715
2300
2654
843
77.24
307.65
3.4
1.4
24.45
2.66
iu/l
1.12
1803
219
2635
16453
2.49
184.76
6.8
6.1
1.22
1.22
mmol/l
1.02
2238
14028
4327
35517
11.16
182.42
17.2
4.8
1.69
2.08
mu/l
3.03
4201
33250
740
2447
3.43
180.03
2.7
3.5
52.97
80.69
ng/l
18.80
664
2116
2382
14812
2.32
159.85
5.6
5.5
1.22
1.22
mmol/l
0.09
2209
13584
3014
21301
2.30
140.84
9.2
9.0
3.66
3.96
e9/l
14.38
2631
18745
1882
11763
2.04
111.43
2.8
3.3
2.34
2.36
mmol/l
8.29
1703
10536
3472
27448
2.23
103.21
8.4
7.2
79.48
75.45
u/l
7.18
3334
25957
120
157
7.83
86.26
1.6
1.5
16.06
14.33
pmol/l
1.61
106
130
2217
15928
1.79
75.61
2.5
2.3
74.70
76.43
nmol/l
2.37
2038
14634
3359
27687
1.89
68.59
4.0
4.0
10.74
11.05
mm/h
0.82
3173
25924
169
437
3.98
57.78
4.0
4.5
97.59
65.38
u/ml
0.48
65
130
4132
37466
2.57
54.68
13.4
12.8
139.75
139.67
mmol/l
1.31
4048
36509
4138
37595
2.57
53.62
13.7
12.9
3.93
3.93
mmol/l
0.03
4050
36562
1389
9487
1.68
51.01
1.4
1.3
2.04
1.59
u/ml
0.55
374
2687
2287
18049
1.55
43.80
5.1
6.0
29.42
29.08
%
0.85
2128
17022
4265
39855
2.98
42.44
12.7
9.5
24.66
25.08
u/l
1.00
4194
38643
2251
17803
1.54
41.96
4.9
5.8
55.83
56.57
%
2.34
2090
16768
2196
17356
1.53
40.50
5.1
6.0
2.81
2.82
%
0.11
2037
16282
2388
19215
1.53
40.49
5.2
6.1
0.18
0.19
e9/l
0.17
2123
17086
2133
16766
1.53
40.27
5.1
6.0
0.66
0.69
%
1.97
1966
15675
2202
17450
1.52
39.85
5.3
6.3
8.50
8.21
%
3.85
2040
16422
3864
35060
1.81
36.89
11.9
10.7
87.94
86.26
ml/min/173m2
5.51
3283
28871
2356
19126
1.50
36.71
5.0
5.9
1.88
1.96
e9/l
2.51
2115
17153
2288
18561
1.48
35.11
5.0
5.9
0.04
0.04
e9/l
7.35
1996
16230
2281
18526
1.48
34.58
5.0
5.9
0.55
0.55
e9/l
0.24
1995
16225
1140
8090
1.55
32.89
1.5
1.4
2.13
2.23
g/l
1.60
673
5063
4055
37653
1.93
31.71
12.3
12.1
19.29
20.59
mg/l
1.74
3205
29379
2028
16321
1.45
30.87
10.4
8.6
0.00
0.00
e9/l
0.32
1684
13337
217
938
2.38
30.13
1.3
1.2
—
—
—
0
0
2390
19903
1.44
29.81
4.0
4.3
6.52
6.48
mmol/l
0.46
2218
18352
4194
39542
2.18
29.34
14.5
13.4
68.68
70.32
umol/l
4.77
4194
39534
3644
33081
1.58
28.29
18.5
14.4
14.63
14.60
%
0.11
3596
32524
577
3614
1.69
27.36
2.0
2.1
377.85
372.05
nmol/l
0.32
532
3325
3617
32900
1.55
26.56
5.3
4.9
39.05
38.57
mmol/mol
2.03
3364
30852
3850
35591
1.63
25.67
4.2
4.0
5.80
5.75
mmol/l
1.48
3566
33027
2174
18276
1.37
23.02
3.0
2.9
95.30
91.48
ug/l
0.36
2032
17184
4350
42098
3.05
21.30
23.8
17.8
40.51
40.05
%
2.91
4188
39902
4353
42171
3.07
20.72
23.9
17.9
6.47
6.64
e9/l
4.52
4286
41179
4353
42177
3.06
20.60
23.9
17.8
4.54
4.47
e12/l
24.69
4285
41203
4351
42148
3.01
20.58
23.9
17.9
263.67
262.68
e9/l
0.52
4295
41245
4353
42191
3.03
20.31
24.0
17.9
135.58
134.14
g/l
12.69
4329
41711
430
2692
1.66
20.16
3.8
3.5
1.22
1.23
mmol/l
1.76
382
2351
1129
8671
1.41
20.03
2.0
2.1
—
—
—
0
0
1636
13441
1.34
18.78
1.9
1.9
95.98
98.47
pmol/l
1.27
861
6867
1728
14452
1.32
17.06
3.9
4.5
36.34
36.21
g/l
0.45
1596
13500
808
6033
1.42
16.42
2.5
2.8
2.44
2.44
mmol/l
0.76
689
5301
569
3988
1.49
16.16
3.7
5.4
1.07
1.04
mmol/l
2.17
531
3714
2090
18073
1.30
15.66
5.3
5.9
10.27
10.28
umol/l
0.02
1971
17107
1445
11898
1.32
15.56
3.1
3.1
32.05
90.14
ng/l
0.65
801
6704
144
706
2.07
14.81
1.9
2.0
4.97
5.30
mmol/24h
0.68
124
627
2026
17529
1.29
14.80
2.4
2.5
—
—
—
0
0
693
5150
1.41
14.30
2.9
3.3
0.80
0.82
mmol/l
4.74
649
4833
1653
14073
1.28
13.24
11.5
11.0
1.20
1.15
inr
1.61
570
4276
958
7596
1.33
13.04
2.9
2.9
977.32
980.86
ng/l
0.01
793
6358
1073
8734
1.30
11.95
2.2
2.2
2.69
2.85
mg/l
1.80
935
7502
112
559
2.03
11.07
1.3
1.2
—
—
—
0
0
2836
26056
1.25
10.71
3.1
2.9
40.70
40.40
u/l
0.07
2692
24592
81
370
2.21
10.10
1.2
1.1
92.51
56.83
u/l
2.75
72
343
57
227
2.53
9.67
1.5
1.6
6.36
5.86
u/l
0.11
45
193
1024
8515
1.26
9.27
2.0
1.7
0.79
0.98
mg/l
3.14
775
6428
1284
11002
1.24
8.83
2.4
2.5
73.35
65.38
u/l
0.17
1172
10191
297
2076
1.46
8.48
1.1
1.1
102.73
181.23
titre
0.73
15
53
3830
36769
1.31
8.41
4.1
4.0
4.75
4.84
mmol/l
6.53
3588
34666
3874
37268
1.32
8.24
4.5
4.3
2.85
2.89
mmol/l
1.57
3609
34951
3805
36575
1.29
7.70
4.1
3.9
1.50
1.53
mmol/l
5.03
3558
34345
22
58
3.81
7.51
1.3
1.3
60.74
84.83
ng/l
1.02
22
58
727
5949
1.27
7.37
3.6
3.3
125.09
368.81
ng/l
3.57
485
3929
3673
35218
1.25
7.17
3.7
3.6
1.23
1.26
mmol/l
1.91
3418
32871
585
4718
1.28
6.66
2.1
2.3
2.45
2.41
g/l
0.88
533
4370
194
1314
1.50
6.55
1.9
1.9
—
—
—
0
0
169
1115
1.54
6.45
1.6
1.7
117.50
399.57
titre
—
8
47
182
1225
1.51
6.34
1.1
1.1
5.30
4.73
u/ml
0.10
32
171
673
5568
1.25
6.15
1.7
1.7
1083.29
1187.27
nmol/l
2.56
533
4256
402
3119
1.32
6.14
2.3
2.6
1.64
1.76
%
1.96
364
2773
5
268
0.19
5.88
20.8
17.9
1320.00
5057.18
nmol/l
—
5
260
5
263
0.19
5.73
17.2
12.5
702.00
873.03
nmol/l
—
5
251
52
253
2.07
5.69
1.1
1.1
5.30
5.79
nmol/l
—
6
48
629
5209
1.24
5.68
2.1
2.3
13.93
13.77
umol/l
0.21
574
4867
24
81
2.97
5.67
1.2
1.6
0.49
0.36
ug/l
0.50
12
54
876
7511
1.21
5.63
1.3
1.3
27.80
27.02
iu/ml
0.06
262
2492
174
1193
1.48
5.58
1.7
1.8
—
—
—
0
0
383
3000
1.30
5.47
1.4
1.3
28.74
29.40
iu/l
0.15
335
2603
835
7159
1.21
5.35
1.3
1.3
6.40
10.02
u/ml
1.14
304
2967
1120
9862
1.18
5.31
2.0
2.1
222.94
185.48
u/l
0.23
1049
9303
528
4333
1.25
5.17
2.2
2.4
22.91
23.22
%
0.20
451
3725
285
2159
1.34
5.17
3.2
2.8
140.24
154.21
ng/l
0.41
250
1939
176
1233
1.45
5.08
1.3
1.3
54.00
33.03
u/ml
—
9
87
1011
8856
1.18
5.07
3.7
3.6
93.29
95.72
%
2.54
984
8606
2602
24516
1.15
4.82
4.3
4.2
2695.37
1923.62
e6/l
0.19
35
286
9
11
8.20
4.56
1.4
2.8
—
—
—
0
0
1055
9392
1.16
4.24
1.7
1.6
1.32
1.38
mmol/l
1.69
872
8050
1113
9949
1.16
4.24
3.1
3.0
24.30
85.29
e6/l
3.41
844
7526
149
1057
1.42
4.09
1.3
1.2
128.57
166.25
titre
0.26
14
96
832
7301
1.17
4.01
1.5
1.5
20.17
21.03
nmol/l
1.03
715
6317
284
2233
1.29
4.01
2.0
2.6
72.54
71.44
e9/l
0.18
214
1659
109
732
1.50
3.98
1.9
2.2
5.46
4.57
umol/l
0.43
74
536
1365
12430
1.14
3.95
3.1
3.1
29.08
31.49
u/l
1.12
1304
11845
90
581
1.56
3.93
1.1
1.1
141.35
17353.99
iu/ml
0.61
24
150
488
4094
1.22
3.89
4.3
4.0
32.75
32.55
%
0.16
353
2917
394
3237
1.24
3.85
3.0
3.0
—
—
—
0
0
575
4907
1.20
3.83
1.8
1.8
—
—
—
0
0
153
1107
1.40
3.78
1.2
1.3
2.53
5.73
u/ml
0.63
11
124
41
219
1.88
3.58
1.1
1.1
—
24.32
u/ml
—
0
22
153
1121
1.38
3.54
1.3
1.3
32.58
7.17
u/ml
0.62
17
201
486
4116
1.20
3.53
2.8
2.6
5.96
6.72
umol/l
0.73
421
3514
16
58
2.77
3.41
1.4
1.4
—
—
—
0
0
97
660
1.48
3.38
1.1
1.0
2.98
3.75
u/ml
0.30
50
332
56
339
1.66
3.24
1.1
1.3
—
—
titre
—
0
0
79
520
1.53
3.23
1.2
1.3
0.44
0.42
nmol/l
—
5
22
132
962
1.38
3.19
1.2
1.3
44.12
38.82
u/ml
0.14
15
105
1014
9169
1.14
3.18
3.1
2.9
0.30
0.37
e6/l
0.95
756
6877
78
515
1.52
3.16
1.2
1.3
0.59
0.61
nmol/l
0.14
78
495
605
5288
1.17
3.05
1.9
2.3
107.44
112.52
ug/g
0.12
479
4180
1323
12193
1.12
3.02
3.6
3.4
72.01
85.62
e6/l
0.42
912
8254
1953
18402
1.11
2.96
3.4
3.5
0.00
0.00
estimate
2.18
412
3647
1957
18445
1.11
2.94
4.6
4.7
0.00
0.00
estimate
0.80
402
3479
784
7003
1.15
2.94
2.5
2.4
7.51
7.33
e6/l
0.10
690
6263
335
2798
1.21
2.85
2.1
2.7
10.19
10.46
g/l
0.66
304
2571
797
7158
1.14
2.75
1.6
1.6
71684476.16
34867343.13
pmol/l
0.72
671
6086
119
877
1.37
2.73
1.2
1.3
0.93
2.93
u/ml
—
7
71
115
844
1.37
2.71
2.2
2.1
38.43
38.25
g/l
0.15
103
756
1967
18605
1.10
2.68
3.4
3.5
0.00
0.00
estimate
0.20
390
3432
105
764
1.38
2.62
2.3
2.2
0.01
0.00
g/l
0.50
99
712
157
1216
1.30
2.59
1.5
1.3
10.97
12.07
u/l
0.44
132
1021
146
1122
1.31
2.56
2.5
3.6
24.92
24.95
mmol/l
0.04
134
1042
210
1696
1.25
2.49
2.5
3.4
1.59
1.73
mmol/l
0.19
146
1272
169
1330
1.28
2.49
1.6
1.9
—
—
—
0
0
63
422
1.50
2.46
3.6
3.1
0.78
0.79
nmol/l
0.11
53
331
6
12
5.01
2.40
1.0
1.1
—
—
—
0
0
122
925
1.33
2.37
2.2
2.3
0.13
0.68
g/l
4.57
108
821
218
1780
1.24
2.36
2.6
3.4
5.22
5.18
kpa
0.32
209
1706
984
9032
1.12
2.35
4.1
3.8
7.76
8.85
mg/mmol
0.32
600
5550
133
1025
1.31
2.31
2.2
2.2
2.87
2.95
g/l
0.47
121
939
120
912
1.32
2.31
1.3
1.4
28.18
27.18
u/l
0.11
98
754
572
5088
1.14
2.29
2.8
2.6
3.72
3.75
e6/l
0.02
320
2631
429
3748
1.16
2.22
4.4
4.3
2.04
2.29
ug/l
0.35
371
3371
156
1237
1.27
2.20
1.4
1.9
0.23
0.23
g/l
0.01
146
1163
110
833
1.33
2.18
2.3
2.1
0.01
0.01
g/l
0.19
104
776
937
8622
1.11
2.13
3.5
3.2
528.53
393.77
mg/l
0.32
581
5270
1051
9732
1.10
2.12
3.2
3.2
7.32
7.31
mmol/l
0.02
899
8379
944
8700
1.11
2.08
2.3
2.3
3114.08
3946.19
umol/l
0.28
829
7776
189
1545
1.23
2.06
2.4
2.6
0.25
0.28
e6/l
0.15
181
1480
373
3245
1.16
2.06
4.5
4.2
228.85
241.43
u/l
1.15
350
3072
204
1686
1.22
2.01
1.6
1.6
—
—
—
0
0
17
83
2.05
2.01
1.0
1.0
—
—
—
0
0
46
304
1.52
1.97
2.0
2.0
18.79
19.39
nmol/l
0.17
41
290
357
3108
1.16
1.96
1.4
1.5
—
—
—
0
0
272
2319
1.18
1.94
2.2
2.6
65.75
67.04
g/l
2.13
248
2124
192
1587
1.22
1.91
2.0
2.0
40.21
39.53
u/l
0.17
176
1455
276
2360
1.18
1.90
1.1
1.0
—
—
—
0
0
136
1084
1.26
1.88
2.4
2.2
7.44
7.40
g/l
0.08
123
997
136
1084
1.26
1.88
2.4
2.2
—
—
—
0
0
28
166
1.69
1.87
1.1
1.4
159.07
149.07
mmol/24h
0.35
28
166
0
53
0.00
1.86
0.0
1.2
—
—
—
0
0
43
284
1.52
1.86
1.1
1.2
80.00
222.13
titre
—
7
61
209
1748
1.21
1.85
1.3
1.3
0.49
1.38
u/ml
1.62
16
158
125
989
1.27
1.84
2.5
2.2
9.39
10.22
g/l
2.01
113
896
74
544
1.37
1.83
1.2
1.3
49.98
47.93
u/ml
—
5
37
157
1278
1.24
1.82
1.5
1.9
1.19
1.18
g/l
0.25
146
1205
32
199
1.61
1.80
1.2
1.1
—
—
—
0
0
64
461
1.39
1.79
1.1
1.1
1.48
1.49
g/l
0.07
58
410
34
215
1.59
1.79
1.1
1.1
72.21
78.93
u/l
0.17
28
191
135
1083
1.25
1.78
2.4
2.2
3.58
3.61
g/l
0.10
122
998
32
499
0.64
1.78
6.2
5.6
394.08
374.22
umol/l
0.36
26
427
46
312
1.48
1.77
1.3
1.4
—
—
—
0
0
14
273
0.51
1.77
1.0
1.5
—
—
—
0
0
239
2796
0.85
1.75
2.4
2.5
70.17
70.67
ml/min/173m2
0.06
84
1082
76
566
1.35
1.75
1.1
1.2
—
—
—
0
0
1504
14262
1.08
1.75
3.5
3.6
—
—
—
0
0
2898
28185
1.08
1.73
3.5
3.4
—
—
—
0
0
173
2081
0.82
1.73
1.5
1.5
—
—
—
0
0
147
1197
1.24
1.71
1.7
1.8
1.42
1.52
g/l
0.71
124
1032
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
33
210
1.58
1.70
1.2
1.1
—
—
—
0
0
33
210
1.58
1.70
1.2
1.1
13.26
21.15
u/l
0.75
27
183
0
49
0.00
1.68
0.0
1.9
—
1.21
—
0
41
35
227
1.55
1.67
1.8
1.8
—
—
—
0
0
965
9007
1.09
1.63
1.6
1.6
—
—
—
0
0
292
2545
1.16
1.62
2.7
3.6
5.88
5.83
kpa
0.38
275
2465
46
319
1.45
1.61
1.3
1.2
0.29
1.23
u/ml
1.75
24
157
124
1000
1.25
1.60
2.0
2.1
9.59
11.12
mg/l
1.77
114
935
290
2530
1.16
1.60
2.7
3.6
2.00
1.91
mmol/l
0.15
226
2149
241
2075
1.17
1.58
1.4
1.4
—
—
—
0
0
42
288
1.46
1.57
1.1
1.1
1.08
1.04
ratio
1.31
18
108
1034
9696
1.09
1.56
3.7
3.8
0.00
0.00
estimate
2.17
397
3430
43
298
1.45
1.53
1.6
1.6
—
—
—
0
0
44
307
1.44
1.51
1.2
1.4
—
—
—
0
0
53
385
1.38
1.47
2.1
2.1
31.89
26.36
mg/l
0.21
18
104
122
995
1.23
1.45
2.0
2.3
216.17
660.88
ug/l
1.29
112
919
5
16
3.13
1.44
1.0
1.4
—
—
—
0
0
150
1251
1.21
1.43
1.3
1.4
—
—
—
0
0
57
421
1.36
1.43
1.3
1.5
—
—
—
0
0
23
141
1.63
1.41
1.0
1.0
—
—
—
0
0
86
676
1.28
1.41
2.5
2.4
66.40
83.03
ug/min
0.24
60
414
141
1172
1.21
1.40
1.2
1.2
—
—
—
0
0
25
158
1.59
1.37
1.2
1.1
—
—
—
0
0
41
289
1.42
1.36
1.2
1.2
—
—
—
0
0
5
17
2.94
1.36
1.0
1.1
—
—
—
0
0
33
223
1.48
1.35
1.3
1.2
—
—
—
0
0
276
2434
1.14
1.35
2.0
2.1
5217.55
5040.62
u/l
0.04
110
978
57
426
1.34
1.34
1.5
1.4
272.13
322.87
pmol/l
1.14
48
376
0
39
0.00
1.33
0.0
1.1
—
—
—
0
0
51
376
1.36
1.32
1.4
1.5
—
—
—
0
0
375
3377
1.12
1.32
2.6
2.3
41.31
51.77
u/l
0.29
325
2871
66
853
0.77
1.32
2.3
3.9
3.80
3.82
mmol/l
0.17
66
846
248
2179
1.15
1.29
1.6
1.9
1.12
1.34
g/l
3.00
229
2006
13
69
1.89
1.28
1.2
1.1
—
—
—
0
0
9
44
2.05
1.26
1.1
1.1
—
—
—
0
0
343
3082
1.12
1.26
2.2
2.2
0.21
0.22
g/l
0.79
321
2906
312
2790
1.13
1.24
1.4
1.3
137.36
188.99
u/ml
1.35
292
2596
313
2803
1.13
1.22
5.9
8.0
95.68
96.04
%
0.47
296
2707
331
2984
1.12
1.17
3.6
3.8
24.08
21.11
%
2.30
127
1278
102
841
1.22
1.15
1.3
1.3
2.38
4.02
ug/l
2.41
92
759
21
134
1.57
1.14
1.1
1.2
—
—
—
0
0
51
387
1.32
1.13
1.4
1.6
47.63
54.61
%
0.61
35
238
119
1000
1.20
1.11
1.6
1.4
280.68
302.64
ug/g
0.55
75
531
159
1370
1.17
1.11
2.3
2.0
10.41
10.90
nmol/l
0.25
146
1227
93
763
1.22
1.11
2.7
3.8
56.39
56.66
%
0.08
93
763
30
210
1.43
1.08
1.1
1.1
87.65
92.57
%
0.50
20
164
45
338
1.33
1.08
1.4
1.6
—
—
—
0
0
11
59
1.87
1.07
1.0
1.2
—
—
—
0
0
132
1543
0.85
1.06
2.2
1.9
—
—
—
0
0
82
1000
0.82
1.05
2.2
3.8
1.26
1.37
mmol/l
0.60
82
986
80
651
1.23
1.04
1.1
1.1
—
—
—
0
0
100
833
1.21
1.04
1.7
1.3
17.00
19.90
e6/l
0.14
79
636
100
833
1.21
1.04
1.7
1.4
813.05
1402.31
e6/l
0.55
83
674
47
611
0.77
1.03
2.0
2.9
31.43
34.24
umol/l
0.51
40
565
247
2208
1.13
1.03
2.6
2.8
0.69
0.72
ug/l
0.34
144
1326
591
5517
1.08
1.03
2.7
2.5
1.13
1.30
e6/l
0.32
332
3046
92
762
1.21
1.02
1.6
1.6
—
—
—
0
0
91
754
1.21
1.01
1.9
1.7
7870.87
9401.01
e6/l
0.21
61
548
212
1881
1.13
1.00
1.5
1.6
278.42
296.54
mu/l
0.44
180
1678
318
2890
1.11
1.00
2.3
2.4
22.09
23.33
au/ml
0.09
16
269
38
283
1.35
0.98
1.4
1.5
10.37
10.98
umol/l
0.33
38
266
349
3191
1.10
0.98
5.8
7.5
0.88
1.07
mmol/l
0.36
277
2508
7
135
0.52
0.98
3.1
2.3
116.14
153.26
nmol/l
—
7
117
0
30
0.00
0.97
0.0
2.1
—
—
—
0
0
252
2268
1.12
0.96
2.1
2.2
5.58
6.29
ug/l
0.38
214
1996
39
293
1.33
0.95
1.3
1.5
36.28
37.74
%
0.08
25
173
349
3196
1.10
0.95
5.8
7.4
5.11
5.08
kpa
0.30
334
3057
349
3196
1.10
0.95
5.8
7.4
12.75
12.94
kpa
0.27
332
3056
34
250
1.36
0.95
1.0
1.0
—
—
—
0
0
279
2526
1.11
0.95
5.5
6.8
1.24
1.30
mmol/l
0.33
268
2469
0
32
0.00
0.95
0.0
1.0
—
—
—
0
0
149
1704
0.87
0.93
1.3
1.3
242.79
228.59
miu/ml
0.19
82
845
53
418
1.27
0.92
1.5
1.5
—
—
—
0
0
9
52
1.73
0.92
1.2
1.8
5.04
797567.48
nmol/l
—
9
41
89
744
1.20
0.92
1.7
1.8
—
—
—
0
0
67
544
1.24
0.92
1.7
1.5
—
—
—
0
0
67
544
1.24
0.92
1.7
1.5
—
—
—
0
0
170
1500
1.14
0.90
7.8
10.2
—
—
—
0
0
20
290
0.69
0.89
2.2
2.6
—
—
—
0
0
6
29
2.07
0.89
5.5
3.3
—
—
—
0
0
43
332
1.30
0.89
1.2
1.2
—
—
—
0
0
43
333
1.29
0.87
1.2
1.2
—
—
—
0
0
254
2304
1.11
0.86
1.5
1.6
—
—
—
0
0
43
334
1.29
0.86
1.2
1.2
—
—
—
0
0
43
334
1.29
0.86
1.2
1.2
—
—
—
0
0
25
178
1.41
0.86
1.7
2.7
165.85
173.68
umol/l
0.04
13
97
43
335
1.29
0.84
1.2
1.2
—
—
—
0
0
6
31
1.94
0.84
5.5
3.2
29.83
19.22
mg/l
—
6
31
25
179
1.40
0.84
2.2
1.6
—
—
—
0
0
10
57
1.76
0.83
1.0
1.8
—
—
—
0
0
24
171
1.41
0.83
1.6
1.5
—
—
—
0
0
24
172
1.40
0.80
1.6
1.5
—
—
—
0
0
51
410
1.25
0.79
1.8
1.6
—
—
—
0
0
45
358
1.26
0.77
1.4
1.5
275.39
279.58
mosm/kgh2o
0.61
31
284
120
1049
1.15
0.76
2.8
3.6
120.10
1537.63
u/ml
0.85
98
897
6
34
1.77
0.76
1.3
1.2
—
—
—
0
0
9
53
1.70
0.75
1.1
1.2
—
—
—
0
0
150
1336
1.13
0.73
1.7
1.8
—
—
—
0
0
21
150
1.40
0.73
1.1
1.2
—
—
—
0
0
20
142
1.41
0.72
1.6
1.6
—
—
—
0
0
20
142
1.41
0.72
1.6
1.6
—
—
—
0
0
144
1282
1.13
0.71
2.6
2.9
25.46
25.35
mmol/l
0.16
134
1233
65
544
1.20
0.71
1.7
1.7
—
—
—
0
0
5
26
1.92
0.70
1.4
1.0
9.28
8.16
mmol/l
—
5
26
22
161
1.37
0.68
1.1
1.2
—
—
—
0
0
20
144
1.39
0.67
1.6
1.6
—
—
—
0
0
7
43
1.63
0.66
1.1
1.1
—
—
—
0
0
71
606
1.17
0.64
2.5
2.4
17.15
16.57
%
0.57
37
297
42
341
1.23
0.63
1.8
1.5
—
—
—
0
0
41
332
1.24
0.63
1.7
2.3
32.05
32.04
pg
0.00
41
332
99
869
1.14
0.63
1.6
1.6
—
—
—
0
0
36
447
0.80
0.62
2.2
2.3
—
—
—
0
0
41
333
1.23
0.62
1.9
1.7
—
—
—
0
0
50
415
1.21
0.62
1.1
1.1
—
—
—
0
0
14
96
1.46
0.61
1.1
1.1
—
—
—
0
0
8
50
1.60
0.61
1.1
1.0
—
—
—
0
0
125
1117
1.12
0.61
1.4
1.5
—
—
—
0
0
286
2662
1.08
0.61
1.2
1.3
64.67
46.94
au/ml
0.46
11
153
0
21
0.00
0.60
0.0
1.2
—
22.36
—
0
14
8
52
1.54
0.59
1.1
1.2
—
—
—
0
0
87
761
1.15
0.59
1.6
1.6
—
—
—
0
0
165
1502
1.10
0.58
1.5
1.5
—
—
—
0
0
40
327
1.23
0.58
1.1
1.1
—
—
—
0
0
32
255
1.26
0.58
1.3
1.4
1907.77
2785.67
e6/l
0.66
26
179
20
149
1.34
0.57
1.0
1.0
—
—
—
0
0
22
167
1.32
0.56
1.3
1.3
—
—
—
0
0
218
2015
1.09
0.56
1.4
1.4
—
—
—
0
0
972
9403
1.04
0.56
1.5
1.5
—
—
—
0
0
54
457
1.18
0.56
1.2
1.4
—
—
—
0
0
103
916
1.13
0.56
1.6
1.4
0.49
0.43
nmol/l
0.35
77
728
198
1824
1.09
0.55
1.4
1.5
—
—
—
0
0
282
2638
1.07
0.54
6.4
8.2
122.33
121.27
g/l
0.37
272
2569
183
1683
1.09
0.54
1.3
1.4
—
—
—
0
0
94
834
1.13
0.53
1.4
1.4
—
—
—
0
0
6
39
1.54
0.53
1.2
1.1
—
—
—
0
0
53
451
1.18
0.53
1.2
1.4
—
—
—
0
0
18
134
1.34
0.53
1.3
1.3
—
—
—
0
0
18
134
1.34
0.53
1.3
1.3
—
—
—
0
0
6
96
0.62
0.52
1.0
1.2
—
—
—
0
0
18
237
0.76
0.51
1.1
1.2
—
—
—
0
0
9
64
1.41
0.51
1.2
1.1
—
—
—
0
0
53
453
1.17
0.51
1.2
1.4
—
—
—
0
0
198
1834
1.08
0.50
1.6
1.5
—
—
—
0
0
91
810
1.13
0.50
1.0
1.1
1.86
1.36
u/ml
0.25
45
385
284
2668
1.07
0.50
3.2
3.2
52.61
47.06
u/ml
0.14
273
2582
54
463
1.17
0.50
1.2
1.4
—
—
—
0
0
35
288
1.22
0.50
1.2
1.2
—
—
—
0
0
106
953
1.12
0.50
1.4
1.3
454.14
484.21
mg/l
0.36
99
913
22
171
1.29
0.49
1.3
1.3
—
—
—
0
0
10
144
0.69
0.49
1.1
1.1
—
—
—
0
0
20
257
0.78
0.49
2.6
3.7
—
—
—
0
0
53
455
1.17
0.49
1.2
1.4
—
—
—
0
0
34
280
1.22
0.48
1.4
1.3
—
—
—
0
0
7
47
1.49
0.47
1.0
1.0
—
—
—
0
0
182
1687
1.08
0.47
1.3
1.4
—
—
—
0
0
182
1689
1.08
0.46
1.3
1.4
—
—
—
0
0
250
2348
1.07
0.46
1.3
1.4
—
—
—
0
0
181
1680
1.08
0.45
1.3
1.4
—
—
—
0
0
93
836
1.11
0.45
1.2
1.3
—
—
—
0
0
35
292
1.20
0.45
1.2
1.2
—
—
—
0
0
7
50
1.40
0.45
3.6
2.0
—
—
—
0
0
46
394
1.17
0.44
1.2
1.5
—
—
—
0
0
52
450
1.16
0.44
1.2
1.4
—
—
—
0
0
95
857
1.11
0.44
2.5
2.9
—
—
—
0
0
182
1693
1.08
0.44
2.7
3.0
132.73
128.87
g/l
1.65
176
1646
348
3310
1.06
0.43
1.7
1.7
—
—
—
0
0
15
113
1.33
0.42
2.2
1.5
—
—
—
0
0
6
91
0.66
0.42
1.2
1.1
—
—
—
0
0
33
276
1.20
0.42
1.5
1.5
—
—
—
0
0
33
276
1.20
0.42
1.5
1.5
—
—
—
0
0
33
276
1.20
0.42
1.5
1.5
—
—
—
0
0
32
267
1.20
0.42
1.9
1.3
4.66
5.03
umol/l
0.24
32
250
0
15
0.00
0.41
0.0
1.6
—
19.57
—
0
7
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
351
3346
1.05
0.41
1.7
1.7
—
—
—
0
0
8
60
1.33
0.40
1.5
1.8
1.19
1.21
mmol/l
—
8
60
0
18
0.00
0.40
0.0
1.0
—
0.27
—
0
6
91
826
1.10
0.39
1.1
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
24
196
1.23
0.39
1.9
2.7
42.98
46.19
%
0.53
12
112
23
187
1.23
0.38
1.2
1.7
1.85
1.97
umol/l
0.44
23
174
73
656
1.11
0.38
2.1
2.3
133.89
130.16
g/l
0.67
54
484
118
1279
0.92
0.37
2.4
2.7
0.65
0.65
%
0.10
118
1270
36
308
1.17
0.37
11.6
5.8
7.36
7.08
mmol/l
0.14
27
265
44
383
1.15
0.37
1.9
1.7
89.34
90.14
%
0.25
44
378
10
72
1.39
0.36
1.1
1.5
—
—
—
0
0
43
374
1.15
0.36
1.8
1.5
—
—
—
0
0
43
374
1.15
0.36
1.8
1.5
—
—
—
0
0
59
661
0.89
0.36
1.1
1.1
0.70
3.90
u/ml
4.93
19
255
88
802
1.10
0.36
3.4
3.3
29.80
55.05
mg/l
1.87
68
652
27
321
0.84
0.36
1.5
1.4
0.92
0.95
g/l
0.32
27
321
20
245
0.82
0.35
2.6
2.1
3.00
2.12
u/field
—
9
110
68
612
1.11
0.35
1.6
1.5
—
—
—
0
0
20
162
1.24
0.35
1.2
1.7
—
—
—
0
0
13
99
1.31
0.35
4.6
3.1
57.33
133.52
ng/l
—
6
46
26
217
1.20
0.35
1.2
1.1
—
—
—
0
0
17
135
1.26
0.35
1.0
1.1
—
—
—
0
0
23
276
0.83
0.34
1.3
1.3
1.60
1.59
g/l
0.05
23
276
88
805
1.10
0.34
3.4
3.3
24.00
44.20
mg/l
1.79
68
655
11
82
1.34
0.34
1.1
1.2
—
—
—
0
0
6
45
1.33
0.33
1.5
1.5
—
—
—
0
0
78
711
1.10
0.33
1.2
1.4
164.39
106.81
u/ml
0.50
22
147
69
625
1.11
0.33
1.1
1.1
116.47
118.97
%
0.24
58
566
21
253
0.83
0.33
1.9
1.7
2.68
3.54
mg/l
0.77
21
244
91
836
1.09
0.33
1.4
1.2
3.84
3.66
mmol/l
0.71
86
791
51
454
1.12
0.32
1.1
1.1
—
2.24
—
0
5
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
7
52
1.35
0.31
1.0
1.4
—
—
—
0
0
65
715
0.91
0.30
1.1
1.1
3.41
3.45
u/ml
0.01
24
322
20
240
0.83
0.30
1.4
3.0
—
—
—
0
0
332
3192
1.04
0.30
3.0
4.0
13.46
32.23
ug/l
0.82
246
2464
776
7945
0.97
0.30
3.6
3.9
1.02
1.02
kg/l
0.16
135
1173
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
77
839
0.92
0.30
4.4
3.5
0.39
0.35
u/ml
0.45
43
480
126
1180
1.07
0.29
2.2
2.1
95.43
94.61
%
0.16
118
1127
86
797
1.08
0.27
1.2
1.3
—
—
—
0
0
458
4718
0.97
0.27
2.3
2.1
30.40
29.34
s
2.55
438
4568
21
247
0.85
0.27
2.5
2.5
—
—
—
0
0
121
1137
1.07
0.27
1.1
1.1
—
—
—
0
0
49
442
1.11
0.27
1.2
1.2
17.63
29.06
u/l
0.77
44
383
19
159
1.20
0.26
1.2
1.7
—
—
—
0
0
90
837
1.08
0.26
1.0
1.1
0.49
1.04
u/ml
1.35
32
342
13
104
1.25
0.26
2.9
4.6
—
—
—
0
0
8
67
1.19
0.26
1.4
1.4
—
—
—
0
0
54
491
1.10
0.26
3.1
3.0
0.91
1.42
%
1.31
46
442
31
272
1.14
0.26
1.2
1.4
1.19
1.47
nmol/l
0.86
26
244
104
974
1.07
0.26
1.1
1.1
2.56
2.02
u/ml
0.15
47
472
61
559
1.09
0.25
1.5
1.5
—
—
—
0
0
33
292
1.13
0.25
3.0
3.5
32.53
28.28
mu/l
0.28
33
282
11
87
1.27
0.24
1.0
1.1
—
—
—
0
0
9
77
1.17
0.24
1.1
1.2
—
—
—
0
0
26
227
1.15
0.23
1.3
1.4
20608.80
80490.44
e6/l
1.02
20
128
52
475
1.10
0.23
1.2
1.4
—
—
—
0
0
70
649
1.08
0.23
1.5
1.4
6.45
7.06
mmol/l
1.78
63
587
13
106
1.23
0.23
1.9
1.4
16.20
17.47
umol/l
0.63
13
95
385
3962
0.97
0.23
1.8
1.8
—
—
—
0
0
60
650
0.92
0.23
1.3
1.2
3.50
4.21
u/ml
0.30
30
258
68
732
0.93
0.22
1.2
1.2
—
—
—
0
0
118
1117
1.06
0.22
4.5
5.8
1.81
1.62
%
0.86
110
1042
7
93
0.75
0.22
1.3
1.2
113.71
109.47
%
—
7
88
66
612
1.08
0.22
1.3
1.3
—
—
—
0
0
20
231
0.87
0.21
2.1
1.7
—
—
—
0
0
121
1148
1.06
0.21
1.1
1.1
—
—
—
0
0
28
248
1.13
0.21
1.7
1.5
4.85
5.55
u/l
0.80
20
213
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
61
565
1.08
0.21
1.6
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
299
3081
0.97
0.20
1.6
1.7
—
—
—
0
0
33
297
1.11
0.20
3.2
2.8
53.30
55.85
%
0.27
27
260
144
1377
1.05
0.20
1.3
1.3
—
—
—
0
0
16
186
0.86
0.19
1.2
1.3
233.06
300.56
u/l
0.43
16
172
70
656
1.07
0.19
2.2
2.3
0.80
0.83
nmol/l
0.12
55
560
26
290
0.90
0.18
1.7
2.1
—
—
—
0
0
113
1078
1.05
0.18
2.8
2.5
3.51
3.61
g/l
0.36
107
1022
426
4167
1.02
0.18
1.6
1.6
—
—
—
0
0
10
121
0.83
0.18
1.4
2.0
—
—
—
0
0
92
874
1.05
0.17
1.0
1.1
3.21
5.39
u/ml
1.16
47
449
41
378
1.09
0.17
1.0
1.1
—
—
—
0
0
19
215
0.88
0.16
1.1
1.1
1574.42
1518.01
miu/ml
0.07
19
215
31
282
1.10
0.16
1.4
1.4
26928.74
90896.26
e6/l
0.85
19
194
46
427
1.08
0.16
1.1
1.2
—
—
—
0
0
82
779
1.05
0.16
1.2
1.2
284.09
262.41
u/ml
0.34
55
487
55
586
0.94
0.15
1.0
1.0
0.13
0.45
u/ml
0.76
16
155
21
234
0.90
0.15
1.1
1.2
—
—
—
0
0
468
4763
0.98
0.14
1.5
1.7
1.32
1.38
%
1.70
410
4256
7
90
0.78
0.14
1.7
1.1
—
—
—
0
0
10
118
0.85
0.14
1.5
1.5
9.86
8.31
ug/l
—
10
118
25
227
1.10
0.14
1.3
1.7
—
—
—
0
0
240
2458
0.98
0.13
6.6
7.3
8.45
8.44
mmol/l
0.01
232
2356
31
335
0.92
0.13
1.2
1.1
—
—
—
0
0
146
1416
1.03
0.12
1.8
1.7
—
—
—
0
0
163
1676
0.97
0.12
1.8
1.8
—
—
—
0
0
20
181
1.11
0.12
1.2
1.6
—
—
—
0
0
170
1746
0.97
0.12
4.4
7.4
24.62
24.46
mmol/l
0.26
159
1660
60
571
1.05
0.12
1.8
1.6
—
—
—
0
0
77
739
1.04
0.11
3.2
3.4
21.60
23.73
mg/l
0.20
40
450
566
5594
1.01
0.10
2.0
2.0
—
—
—
0
0
17
187
0.91
0.10
1.1
1.3
—
627.14
—
0
14
35
331
1.06
0.08
1.2
1.1
—
—
—
0
0
6
56
1.07
0.08
1.2
1.4
—
—
—
0
0
122
1251
0.97
0.08
1.6
1.6
0.08
0.29
iu/ml
0.78
25
250
6
57
1.05
0.08
1.3
1.3
—
—
—
0
0
101
1037
0.97
0.08
2.1
2.0
0.87
2.02
ug/l
1.76
86
919
205
2085
0.98
0.07
2.5
3.0
4.46
4.62
kpa
0.55
193
2015
94
915
1.03
0.07
1.9
1.6
—
—
—
0
0
8
77
1.04
0.07
1.0
1.1
—
—
—
0
0
30
284
1.06
0.07
1.2
1.1
—
—
—
0
0
22
235
0.94
0.07
1.0
1.4
18.54
7.70
ug/l
0.37
16
202
36
343
1.05
0.07
1.2
1.1
239.52
229.36
mg/l
0.11
29
303
114
1116
1.02
0.06
4.6
5.9
0.85
0.92
%
1.23
105
1045
27
256
1.06
0.06
1.2
1.1
1.25
1.08
u/l
0.68
13
108
25
264
0.95
0.06
1.3
1.7
1.26
1.27
promille
0.01
19
205
176
1734
1.02
0.06
2.0
1.7
3.18
3.97
mg/l
0.85
143
1262
12
131
0.92
0.05
1.0
1.1
—
—
—
0
0
37
356
1.04
0.05
1.4
1.1
41.54
36.20
mg/l
0.25
29
303
17
159
1.07
0.05
1.1
1.4
6.60
4.79
%
—
5
29
10
110
0.91
0.05
1.4
2.6
—
—
—
0
0
633
6297
1.01
0.04
2.1
2.1
—
—
—
0
0
54
526
1.03
0.04
1.2
1.1
—
—
—
0
0
44
453
0.97
0.04
1.6
1.7
—
1592.00
—
0
10
174
1760
0.99
0.04
7.5
8.8
0.65
0.69
%
0.77
174
1750
17
180
0.94
0.04
3.8
2.4
13.33
171.71
ug/l
0.76
17
166
398
4001
0.99
0.03
5.3
6.0
—
—
—
0
0
68
668
1.02
0.03
5.4
5.4
183.00
402.13
iu/ml
—
7
84
11
118
0.93
0.02
1.1
1.2
—
—
—
0
0
14
132
1.06
0.02
1.4
1.3
197.37
150.97
pmol/l
0.54
14
132
16
168
0.95
0.02
1.3
1.6
—
1612325.38
—
0
13
18
188
0.96
0.02
1.0
1.4
131.83
131.71
nmol/l
0.00
18
188
63
640
0.98
0.02
1.3
1.3
—
—
—
0
0
63
640
0.98
0.02
1.3
1.3
—
—
—
0
0
65
640
1.02
0.02
5.9
8.5
105.44
105.26
mmol/l
0.13
57
575
176
1772
0.99
0.02
7.5
8.8
94.54
94.17
%
0.54
176
1764
14
147
0.95
0.01
1.6
1.3
154.93
84.53
nmol/24h
0.62
14
147
25
243
1.03
0.01
1.1
1.5
67.88
72.58
umol/l
0.80
25
243
36
353
1.02
0.01
1.2
1.3
20.50
32.55
nmol/l
2.47
31
317
65
643
1.01
0.01
1.2
1.1
—
—
—
0
0
10
106
0.94
0.01
1.1
1.1
—
—
—
0
0
11
108
1.02
0.00
1.1
1.1
—
—
—
0
0
10
95
1.05
0.00
1.0
1.2
—
—
—
0
0
13
135
0.96
0.00
1.1
1.2
—
—
—
0
0
32
318
1.01
0.00
1.1
1.1
—
—
—
0
0
25
245
1.02
0.00
1.1
1.3
—
—
—
0
0
11
106
1.04
0.00
1.2
1.1
—
—
—
0
0
11
106
1.04
0.00
1.2
1.0
—
—
—
0
0
13
126
1.03
0.00
2.1
2.4
—
—
—
0
0
12
123
0.98
0.00
3.0
3.2
—
—
—
0
0
14
137
1.02
0.00
1.8
1.6
—
—
—
0
0
14
137
1.02
0.00
1.8
1.6
—
—
—
0
0
29
294
0.99
0.00
1.0
1.1
5.37
10.40
iu/ml
—
7
81
66
656
1.01
0.00
1.1
1.1
—
—
—
0
0
24
241
1.00
0.00
1.6
1.5
—
—
—
0
0
67
669
1.00
0.00
1.2
1.2
2.67
3.38
u/ml
0.32
27
213
0
8
0.00
0.00
0.0
1.3
—
7.11
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
84
0.95
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.20
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.0
—
—
—
0
0
5
49
1.02
-0.00
2.0
2.6
15.60
15.16
ml/dl
—
5
44
9
99
0.91
-0.00
1.1
1.1
—
—
—
0
0
9
90
1.00
-0.00
1.4
4.7
—
—
—
0
0
9
90
1.00
-0.00
1.4
4.7
—
—
—
0
0
8
80
1.00
-0.00
2.1
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GRAVES_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_STRICT | 1.07 [0.94, 1.22] | 0.294 |
| Birth year | 0.992 [0.98, 1.0] | 0.082 |
During the follow-up period (1.1.1998 — 31.12.2019), 1142 out of 16342 females with E4_GRAVES_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_STRICT | 1.036 [0.89, 1.21] | 0.654 |
| Birth year | 0.991 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 345 out of 3489 males with E4_GRAVES_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GRAVES_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.176% |
| 5 | 0.599% | 1.156% |
| 10 | 1.414% | 3.262% |
| 15 | 2.705% | 6.508% |
| 20 | 4.747% | 11.059% |
Relationships between endpoints
↥Index endpoint: E4_GRAVES_STRICT – Graves disease, strict definition
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data