No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
8809 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
4123 |
6. Filter based on genotype QC (FinnGen only) |
4123 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF7
Similar endpoints
↥List of similar endpoints to
Graves disease, strict definition
based on the number of shared cases.
Similar with more cases:
- Carbimazole or st.post thyroidectomy, condition for graves disease
- Thyrotoxicosis
- Disorders of thyroid, IBD co-morbidities
- Disorders of the thyroid gland
- Used for control exclusion in common control thyroid runs
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 23064 | 18836 | 4057 |
| Only index persons | 22484 | 18513 | 3971 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.46 | 0.54 | 0.11 |
| Only index persons | 0.59 | 0.68 | 0.15 |
| Median age at first event (years) | |||
| Whole population | 49.31 | 49.21 | 50.36 |
| Only index persons | 49.26 | 49.12 | 49.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4123 | 3491 | 632 |
| Unadjusted period prevalence (%) | 1.05 | 1.19 | 0.28 |
| Median age at first event (years) | 49.40 | 48.66 | 53.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3572
- Matched controls
- 35718
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
BAA60
NOMESCO Finland
Total thyroidectomy
54.3
323.0
1079
282
H03AA01
ATC
levothyroxine sodium; systemic
12.3
323.0
2558
6060
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
117.7
323.0
1687
270
C07AA05
ATC
propranolol; systemic
5.8
323.0
1706
4837
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
10985.0
323.0
3521
182
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
45.5
323.0
675
182
H03BB01
ATC
carbimazole; oral
4425.3
323.0
3487
361
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
63.4
323.0
440
79
104
Kela drug reimbursment
Thyroid insufficiency
9.0
323.0
952
1388
E05
ICD-10 Finland
Thyrotoxicosis [hyperthyroidism]
104.9
323.0
602
69
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
234.5
323.0
469
23
E05.2
ICD-10 Finland
Thyrotoxicosis with toxic multinodular goitre
32.4
266.9
357
122
XX7CT
NOMESCO Finland
Radioiodine therapy of thydoid tissue
32.6
225.0
300
100
T85
ICPC
Hyperthyroidism/thyrotoxicosis
54.7
184.8
221
43
C07AB07
ATC
bisoprolol; oral
2.9
184.5
1786
9273
H06.2
ICD-10 Finland
Dysthyroid exophthalmos
185.0
169.4
176
10
BA1AE
NOMESCO Finland
Thyroiid ultrasound examination
14.4
168.6
295
222
H062, E050
ICD-10 Finland
NA
396.5
153.4
153
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.8
116.9
424
975
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.3
113.3
1675
10004
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
103.7
1327
7304
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
7.9
89.2
212
282
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
35.2
81.5
106
31
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
34.5
79.6
104
31
E05.1
ICD-10 Finland
Thyrotoxicosis with toxic single thyroid nodule
45.4
75.5
93
21
T86
ICPC
Hypothyroidism/myxoedema
4.6
74.3
277
646
E05.89
ICD-10 Finland
Other thyrotoxicosis
40.1
71.3
90
23
E05.80
ICD-10 Finland
Subacute thyrotoxicosis
16.3
69.6
114
72
H03BA02
ATC
propylthiouracil; oral
132.3
61.0
65
5
E89.2
ICD-10 Finland
Postprocedural hypoparathyroidism
22.3
59.4
87
40
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.4
59.1
229
553
E05.5
ICD-10 Finland
Thyroid crisis or storm
280.4
54.3
55
*
H05.2
ICD-10 Finland
Exophthalmic conditions
24.0
46.3
66
28
CA1AD
NOMESCO Finland
Orbita CT
40.6
44.8
56
14
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.2
44.6
536
2702
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
11.1
40.0
77
71
E89.09
ICD-10 Finland
Postprocedural hypothyroidism, other or several procedures
25.4
39.3
55
22
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.6
39.2
186
537
E03
ICD-10 Finland
Other hypothyroidism
2.7
39.2
293
1155
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
5.6
39.1
117
214
BA3AT
NOMESCO Finland
Cytology of thyroid with ultrasound quidance
5.4
36.4
113
216
A11CC03
ATC
alfacalcidol; systemic
5.4
35.5
109
206
E06.2
ICD-10 Finland
Chronic thyroiditis with transient thyrotoxicosis
340.3
34.0
34
*
ZXA10
NOMESCO Finland
Bilateral
1.8
31.3
603
3601
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
28.8
879
5988
E83.51
ICD-10 Finland
Hypocalcemia
10.5
27.7
54
52
CAC30
NOMESCO Finland
Decompression of orbit to sinuses
60.5
26.0
30
5
106
Kela drug reimbursment
Hypoparathyroidism
14.5
25.6
43
30
H53.2
ICD-10 Finland
Diplopia
3.5
25.6
124
366
H02AB06
ATC
prednisolone; systemic
1.4
23.7
1497
11889
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
23.7
369
2033
CAC44
NOMESCO Finland
Combined decompression of orbit
231.4
22.6
23
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
4.3
21.8
81
190
E06.3
ICD-10 Finland
Autoimmune thyroiditis
6.1
21.6
59
98
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.6
21.3
162
645
CBK00
NOMESCO Finland
Myotomy or resection of tarsal muscle or levator muscle of eyelid for correction of retraction
+∞
20.8
20
*
CAC20
NOMESCO Finland
Lateral decompression of orbit
+∞
20.8
20
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
20.3
716
4993
C07AB02
ATC
metoprolol; systemic
1.6
20.1
522
3367
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
20.0
504
3227
XCK00
NOMESCO Finland
Perimetry
2.2
19.8
213
1010
H50.2
ICD-10 Finland
Vertical strabismus
5.3
18.5
56
106
2420A
ICD-9 Finland
Thyrotoxicosis with or without goitre, Toxic diffuse goitre
14.2
18.5
31
22
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.8
18.5
317
1802
E05.4
ICD-10 Finland
Thyrotoxicosis factitia
16.6
17.8
28
17
A11CC02
ATC
dihydrotachysterol; oral
15.4
16.2
26
17
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.1
16.0
86
278
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
15.7
379
2390
CA1BD
NOMESCO Finland
Extensive orbita CT
33.5
15.7
20
6
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
3.9
15.7
65
171
R00.2
ICD-10 Finland
Palpitations
1.8
15.5
253
1414
BBA70
NOMESCO Finland
Implantation or transplantation of parathyroid gland
20.1
15.1
22
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.4
15.1
1137
9108
E89.0
ICD-10 Finland
Postprocedural hypothyroidism
14.0
15.0
25
18
E04.0
ICD-10 Finland
Nontoxic diffuse goitre
4.4
14.6
52
119
WX402
NOMESCO Finland
General anaesthesia
1.5
14.0
514
3588
BAA50
NOMESCO Finland
Lobectomy and resection of contralateral lobe of thyroid gland
14.7
13.6
22
15
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
13.5
13
*
ZX120
NOMESCO Finland
Intravenous
1.7
13.1
266
1595
K90.0
ICD-10 Finland
Coeliac disease
2.4
13.0
106
442
H02.5
ICD-10 Finland
Other disorders affecting eyelid function
14.1
12.7
21
15
H02AB07
ATC
prednisone; oral
1.5
12.6
422
2883
E04.9
ICD-10 Finland
Nontoxic goitre, unspecified
2.6
12.1
86
334
H50.8
ICD-10 Finland
Other specified strabismus
13.4
11.9
20
15
H50.6
ICD-10 Finland
Mechanical strabismus
22.9
11.6
16
7
TPH04
NOMESCO Finland
Cathetrisation of vein
1.4
11.5
549
4036
2AB04
NOMESCO Finland
NA
7.5
11.4
26
35
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
2.1
11.3
126
611
R94.6
ICD-10 Finland
Abnormal results of thyroid function studies
6.2
11.2
29
47
WF099
NOMESCO Finland
Other radiotherapy
5.2
10.4
31
60
N07BA03
ATC
varenicline; oral
1.8
10.3
161
891
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
2.3
10.0
90
396
E05.3
ICD-10 Finland
Thyrotoxicosis from ectopic thyroid tissue
40.2
10.0
12
*
E06.9
ICD-10 Finland
Thyroiditis, unspecified
4.9
9.9
31
64
N02BE01
ATC
paracetamol; systemic, rectal
1.3
9.6
2858
26904
K04
ICPC
Palpitations/awareness of heart
1.8
9.4
153
857
A02BC02
ATC
pantoprazole; systemic
1.2
9.3
1980
17841
BAA25
NOMESCO Finland
Bilateral partial excision of thyroid gland
8.7
9.3
19
22
E89.1
ICD-10 Finland
Postprocedural hypoinsulinaemia
18.6
8.9
13
7
H50.0
ICD-10 Finland
Convergent concomitant strabismus
4.0
8.9
34
86
SPAT1249
SPAT
Treatment-related counselling outside office
1.3
8.6
1227
10532
E06.1
ICD-10 Finland
Subacute thyroiditis
3.7
8.6
36
99
CEC90
NOMESCO Finland
Total transposition of extraocular muscle or muscles
27.6
8.5
11
*
WX110
NOMESCO Finland
Local anesthesy
1.2
8.5
2277
20950
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
1.9
8.4
124
674
G73.0*E05.9
ICD-10 Finland
Myasthenic syndromes in thyrotoxicosis [hyperthyroidism]
90.3
8.4
9
*
TFP20
NOMESCO Finland
Cardiodefibrillation
1.8
8.1
123
679
K80
ICPC
Cardiac arrhythmia NOS
1.6
8.0
188
1179
XW1AT
NOMESCO Finland
Biopsy from other organ close to skin with ultrasound quidance
4.6
8.0
26
57
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
4.1
8.0
29
71
XCK10
NOMESCO Finland
Photography of fundus of eye
1.6
7.8
225
1483
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
7.7
447
3387
CEC00
NOMESCO Finland
Recession of extraocular muscle
4.2
7.7
27
64
E20.8
ICD-10 Finland
Other hypoparathyroidism
18.4
7.6
11
6
M14.5*E05.9
ICD-10 Finland
Arthropathy in thyrotoxicosis [hyperthyroidism]
80.2
7.4
8
*
A04
ICPC
Weakness/tiredness general
1.4
7.3
337
2458
H04AA01
ATC
glucagon; nasal, parenteral
2.1
7.2
74
351
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
15.8
7.2
11
7
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.7
7.1
143
863
R63.4
ICD-10 Finland
Abnormal weight loss
2.1
7.1
73
349
Z50.5
ICD-10 Finland
Speech therapy
3.0
7.0
38
129
SGA01
NOMESCO Finland
Tooth opening as first aid
1.3
6.7
489
3843
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
1.6
6.7
144
887
8341/3-C73.9
ICD-O-3
Papillary microcarcinoma of thyroid gland
10.0
6.5
12
12
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
1.9
6.5
84
437
B01AA03
ATC
warfarin; systemic
1.4
6.4
310
2281
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.3
6.4
469
3688
CKC12
NOMESCO Finland
Photocoagulation of retina
1.8
6.3
99
554
CE2W4
NOMESCO Finland
Eye movement mapping
9.3
6.3
12
13
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.2
6.3
1756
15986
E8901, E050
ICD-10 Finland
NA
+∞
6.2
6
*
E50.9
ICD-10 Finland
Vitamin A deficiency, unspecified
+∞
6.2
6
*
O992, E050
ICD-10 Finland
NA
+∞
6.2
6
*
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
7.0
6.2
14
20
T89
ICPC
Diabetes insulin dependent
1.8
6.1
99
562
WX290
NOMESCO Finland
Other blockade of nerve
1.2
6.1
1439
12889
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
8.6
6.0
12
14
CEW99
NOMESCO Finland
Other operation on extraocular muscle
8.6
6.0
12
14
E10
ICD-10 Finland
Type 1 diabetes mellitus
2.2
6.0
56
257
GB1AA
NOMESCO Finland
Tracheal X-ray examination
10.0
6.0
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
4018
28784
16.55
312.04
16.4
4.1
15.5
14.5
pmol/l
122.11
3906
26722
2433
808
72.02
307.65
3.5
1.4
25.6
2.8
iu/l
1.09
1688
219
2623
2462
27.54
307.65
8.6
2.7
4.8
4.5
pmol/l
22.82
2483
2189
1307
3102
5.70
307.65
1.4
1.2
239.3
151.3
iu/ml
7.08
730
1166
701
2289
3.48
174.43
2.7
3.6
52.0
80.6
ng/l
18.65
630
1988
2460
15345
2.50
173.32
6.8
6.1
1.2
1.2
mmol/l
2.54
2074
12988
4035
33039
11.37
172.79
17.6
4.8
1.7
2.0
mu/l
2.69
3920
30910
2227
13825
2.33
150.65
5.7
5.5
1.2
1.2
mmol/l
0.90
2059
12578
2791
19878
2.25
124.86
9.4
8.9
3.7
4.0
e9/l
14.04
2449
17486
1762
10955
2.06
106.68
2.8
3.3
2.3
2.4
mmol/l
10.42
1585
9743
3219
25566
2.18
91.87
8.5
7.2
79.1
75.6
u/l
5.06
3081
24150
116
144
8.26
87.17
1.6
1.5
16.2
14.1
pmol/l
2.06
102
121
2062
14840
1.78
69.64
2.5
2.3
74.7
76.4
nmol/l
2.31
1894
13634
3119
25783
1.86
61.75
4.0
4.0
10.7
11.1
mm/h
0.94
2938
24138
162
410
4.07
57.09
4.1
4.6
100.2
68.8
u/ml
0.41
58
120
3852
34930
2.56
50.93
13.3
12.8
139.7
139.7
mmol/l
1.40
3771
34045
3858
35053
2.57
50.00
13.6
12.9
3.9
3.9
mmol/l
2.55
3773
34095
1288
8818
1.67
46.76
1.4
1.3
2.1
1.6
u/ml
0.52
340
2494
3970
37141
2.86
38.04
12.8
9.5
24.5
25.1
u/l
1.48
3900
36013
2111
16811
1.52
37.51
5.2
6.0
29.5
29.1
%
1.03
1943
15732
2079
16592
1.51
35.95
5.0
5.8
55.8
56.6
%
2.56
1921
15574
2027
16165
1.50
34.69
5.2
6.0
2.8
2.8
%
0.33
1870
15067
2209
17948
1.50
34.37
5.3
6.1
0.2
0.2
e9/l
0.28
1970
15951
3585
32614
1.76
32.19
11.7
10.7
87.9
86.2
ml/min/173m2
5.33
3047
26832
2181
17831
1.47
31.84
5.0
5.9
1.9
2.0
e9/l
1.84
1948
15910
1055
7545
1.54
29.19
1.5
1.4
2.1
2.2
g/l
1.65
628
4736
3774
35082
1.90
28.60
12.3
12.1
19.2
20.6
mg/l
1.83
2979
27372
545
3370
1.71
27.27
2.0
2.1
377.0
373.1
nmol/l
0.19
502
3104
1880
15222
1.43
27.16
10.4
8.7
0.0
0.0
e9/l
0.13
1566
12440
2216
18576
1.42
25.83
4.0
4.3
6.5
6.5
mmol/l
0.54
2052
17109
199
887
2.31
25.80
1.3
1.2
—
—
—
0
0
3592
33201
1.64
24.14
4.2
4.0
5.8
5.8
mmol/l
1.32
3330
30797
3366
30702
1.52
23.44
5.3
4.9
39.1
38.6
mmol/mol
1.90
3125
28792
3274
29898
1.46
20.69
18.9
14.6
13.5
13.6
%
1.52
3218
29294
1059
8051
1.42
20.22
2.0
2.1
—
—
—
0
0
403
2509
1.67
19.37
3.8
3.5
1.2
1.2
mmol/l
1.72
357
2188
2001
17017
1.34
18.61
3.0
2.9
94.8
92.0
ug/l
0.23
1872
16006
4056
39322
2.94
18.52
24.0
17.9
4.5
4.5
e12/l
24.62
3990
38414
4054
39293
2.90
18.51
24.0
17.9
263.9
262.7
e9/l
0.60
4001
38457
4056
39328
2.93
18.40
24.1
17.9
6.5
6.6
e9/l
3.66
3991
38406
4056
39331
2.92
18.34
24.1
18.0
135.7
134.1
g/l
14.58
4032
38893
1519
12568
1.33
16.34
1.9
1.9
95.6
98.7
pmol/l
1.69
806
6409
1611
13463
1.32
16.08
3.9
4.5
36.3
36.2
g/l
0.24
1486
12560
528
3709
1.49
14.86
3.6
5.5
1.1
1.0
mmol/l
2.03
492
3448
747
5606
1.41
14.73
2.6
2.8
2.4
2.4
mmol/l
1.57
633
4928
1889
16300
1.29
14.31
3.7
3.9
—
—
—
0
0
646
4796
1.41
13.46
2.8
3.3
0.8
0.8
mmol/l
5.04
599
4477
1339
11111
1.30
13.41
3.1
3.1
32.5
94.4
ng/l
0.64
742
6222
1930
16842
1.27
12.85
5.4
5.9
10.3
10.3
umol/l
0.01
1815
15923
107
522
2.08
11.25
1.3
1.2
—
—
—
0
0
992
8134
1.29
10.37
2.2
2.2
2.7
2.8
mg/l
1.38
866
6992
2646
24293
1.25
10.20
3.1
2.9
40.3
40.6
u/l
0.06
2507
22934
77
346
2.25
9.99
1.2
1.2
100.1
56.9
u/l
2.19
50
239
871
7083
1.29
9.61
2.9
2.8
945.4
982.1
ng/l
0.12
714
5915
54
211
2.58
9.53
1.5
1.6
6.3
5.2
u/l
0.20
25
108
281
1934
1.49
8.70
1.1
1.1
102.7
153.4
titre
0.44
15
51
3468
33099
1.30
8.49
16.7
12.8
40.1
39.7
%
3.02
2698
25787
44
165
2.68
8.46
1.2
1.1
12.0
21.3
u/l
2.01
30
131
44
165
2.68
8.46
1.2
1.1
65.8
78.8
u/l
1.11
32
134
1194
10246
1.23
8.11
2.4
2.5
55.0
56.8
u/l
1.00
1085
9488
178
1136
1.59
7.80
1.1
1.1
4.6
4.5
u/ml
0.01
30
153
640
5173
1.28
7.24
1.8
1.7
1070.9
1193.9
nmol/l
3.24
508
3969
3565
34315
1.29
6.99
4.1
4.0
4.8
4.8
mmol/l
5.50
3334
32301
679
5563
1.26
6.85
3.5
3.3
101.2
369.6
ng/l
4.54
446
3673
160
1030
1.58
6.80
1.6
1.7
117.5
357.6
titre
—
8
42
3606
34786
1.29
6.76
4.5
4.3
2.9
2.9
mmol/l
0.96
3351
32547
940
7996
1.23
6.75
2.0
1.7
0.8
1.0
mg/l
3.38
708
6027
3540
34132
1.26
6.24
4.1
3.9
1.5
1.5
mmol/l
5.14
3304
32001
24
77
3.13
6.15
1.2
1.6
0.5
0.4
ug/l
0.48
12
51
826
7001
1.22
6.08
1.3
1.3
28.9
27.9
iu/ml
0.08
243
2253
791
6685
1.23
5.98
1.3
1.3
6.7
10.1
u/ml
0.98
284
2774
540
4386
1.27
5.83
2.1
2.3
2.5
2.4
g/l
1.19
492
4068
3413
32855
1.23
5.61
3.7
3.6
1.2
1.3
mmol/l
1.74
3173
30662
175
1206
1.47
5.49
1.9
2.0
—
—
—
0
0
5
249
0.20
5.28
20.8
17.6
1320.0
5392.5
nmol/l
—
5
240
414
3304
1.28
5.16
17.7
18.8
1.3
1.2
inr
1.26
74
492
5
244
0.20
5.13
17.2
12.4
702.0
881.5
nmol/l
—
5
233
1041
9162
1.18
5.00
2.0
2.1
230.5
171.4
u/l
0.37
975
8647
267
2019
1.34
4.93
3.2
2.8
145.6
152.8
ng/l
0.17
235
1814
164
1142
1.45
4.91
1.3
1.3
60.7
28.1
u/ml
—
8
80
367
2903
1.29
4.91
2.4
2.6
1.6
1.8
%
1.99
333
2580
158
1098
1.46
4.79
1.7
1.8
—
—
—
0
0
9
10
9.02
4.78
1.4
3.0
—
—
—
0
0
355
2807
1.29
4.77
1.4
1.3
29.0
29.1
iu/l
0.03
310
2432
578
4842
1.23
4.71
2.1
2.3
14.1
13.8
umol/l
0.40
524
4494
992
8784
1.17
4.35
1.7
1.6
1.3
1.4
mmol/l
1.55
817
7525
2418
22833
1.14
4.22
4.3
4.2
1549.1
2064.5
e6/l
0.17
31
265
483
4028
1.23
4.11
2.2
2.4
23.1
23.4
%
0.15
409
3475
94
609
1.56
4.04
1.1
1.1
3.1
3.5
u/ml
0.15
47
303
1277
11601
1.15
3.89
3.1
3.1
29.0
31.6
u/l
1.14
1217
11061
369
3015
1.25
3.81
3.0
2.9
—
—
—
0
0
55
316
1.75
3.78
1.1
1.3
—
—
titre
—
0
0
16
55
2.92
3.73
1.4
1.4
—
—
—
0
0
127
895
1.43
3.66
1.2
1.3
46.8
39.0
u/ml
0.19
13
101
141
1024
1.39
3.45
1.3
1.3
2.5
6.0
u/ml
0.65
11
117
83
547
1.53
3.37
1.1
1.1
154.1
17350.5
iu/ml
0.53
22
135
454
3846
1.20
3.32
4.4
4.0
32.7
32.5
%
0.14
326
2705
531
4564
1.19
3.30
1.8
1.8
—
—
—
0
0
141
1038
1.37
3.20
1.3
1.3
34.4
7.6
u/ml
0.61
16
185
38
207
1.84
3.16
1.1
1.1
—
24.3
u/ml
—
0
22
15
55
2.73
3.15
1.1
1.3
51.0
83.8
ng/l
1.71
15
55
98
680
1.45
3.12
1.8
2.2
5.5
4.5
umol/l
0.43
67
497
564
4910
1.17
3.02
1.9
2.3
110.0
111.2
ug/g
0.02
445
3862
318
2634
1.22
2.94
2.1
2.7
10.2
10.4
g/l
0.58
290
2420
117
853
1.38
2.86
1.3
1.4
27.1
27.3
u/l
0.03
95
712
448
3863
1.18
2.71
2.8
2.6
6.0
6.8
umol/l
0.76
387
3297
137
1036
1.33
2.67
2.5
3.6
24.9
25.0
mmol/l
0.04
125
962
940
8557
1.13
2.65
3.1
2.9
0.3
0.4
e6/l
0.67
705
6374
70
473
1.49
2.60
1.2
1.3
0.6
0.6
nmol/l
0.04
70
455
756
6803
1.14
2.56
1.5
1.5
20.2
21.1
nmol/l
0.94
652
5889
1817
17184
1.10
2.50
4.6
4.7
0.0
0.0
estimate
0.80
376
3231
1807
17086
1.10
2.49
3.3
3.5
0.0
0.0
estimate
1.08
361
3156
202
1625
1.26
2.49
1.3
1.3
0.5
1.3
u/ml
1.53
17
146
1830
17328
1.10
2.44
3.4
3.5
0.0
0.0
estimate
0.20
365
3184
108
804
1.35
2.37
1.2
1.3
0.9
3.0
u/ml
—
6
64
106
787
1.36
2.37
2.3
2.1
38.5
38.2
g/l
0.27
95
690
43
267
1.62
2.34
1.1
1.2
80.0
207.6
titre
—
7
59
194
1570
1.25
2.29
2.4
3.4
1.7
1.7
mmol/l
0.07
135
1182
394
3416
1.17
2.26
4.3
4.3
2.0
2.1
ug/l
0.05
341
3069
202
1646
1.24
2.25
2.5
3.4
5.3
5.2
kpa
0.50
189
1541
71
499
1.43
2.21
1.3
1.3
50.0
43.9
u/ml
—
5
34
736
6673
1.13
2.21
1.6
1.6
64725340.7
34062494.5
pmol/l
0.58
618
5672
145
1139
1.28
2.21
1.4
1.3
11.3
12.1
u/l
0.27
121
956
34
202
1.69
2.20
1.1
1.1
72.2
77.0
u/l
0.12
28
180
147
1157
1.28
2.20
1.5
1.9
0.2
0.2
g/l
0.08
137
1088
157
1246
1.27
2.20
1.6
2.0
—
—
—
0
0
720
6533
1.12
2.13
2.5
2.4
7.4
7.4
e6/l
0.02
611
5706
46
298
1.55
2.13
1.3
1.2
0.2
0.8
u/ml
0.82
22
113
33
197
1.68
2.11
1.2
1.1
13.3
21.4
u/l
0.75
27
172
31
182
1.71
2.11
1.2
1.1
—
—
—
0
0
217
2608
0.82
2.10
2.4
2.5
71.7
71.0
ml/min/173m2
0.08
74
1012
5
10
5.00
2.07
1.0
1.1
—
—
—
0
0
531
4738
1.14
2.06
2.8
2.7
3.9
3.7
e6/l
0.11
301
2430
45
293
1.54
2.05
1.3
1.3
—
—
—
0
0
112
862
1.31
2.01
2.3
2.3
0.1
0.7
g/l
4.08
100
766
12
259
0.46
2.00
1.0
1.5
—
—
—
0
0
52
355
1.47
1.92
2.1
2.1
31.9
26.0
mg/l
0.22
18
98
907
8389
1.10
1.89
1.6
1.6
—
—
—
0
0
876
8097
1.10
1.85
2.3
2.3
3373.0
3991.5
umol/l
0.18
759
7142
148
1195
1.25
1.84
1.5
1.9
1.2
1.2
g/l
0.08
137
1127
42
277
1.52
1.84
1.6
1.7
—
—
—
0
0
121
956
1.27
1.81
2.3
2.2
3.0
3.1
g/l
1.07
98
750
188
1565
1.21
1.77
1.6
1.6
—
—
—
0
0
116
917
1.27
1.74
2.6
2.2
9.5
10.2
g/l
1.53
101
795
2704
26274
1.08
1.73
3.5
3.4
—
—
—
0
0
256
2197
1.18
1.72
1.0
1.0
—
—
—
0
0
907
8430
1.10
1.70
4.3
3.9
7.3
8.8
mg/mmol
0.43
547
5181
0
46
0.00
1.70
0.0
1.9
—
1.3
—
0
38
0
49
0.00
1.68
0.0
1.2
—
—
—
0
0
29
455
0.63
1.67
6.4
5.6
399.5
371.5
umol/l
0.52
24
390
33
211
1.57
1.67
1.8
1.9
—
—
—
0
0
117
932
1.26
1.66
1.6
1.4
280.7
303.2
ug/g
0.56
75
496
251
2159
1.17
1.65
2.3
2.6
65.7
67.0
g/l
1.93
229
1977
226
1927
1.18
1.65
1.4
1.4
—
—
—
0
0
25
150
1.67
1.63
1.2
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
30
189
1.59
1.62
1.2
1.1
—
—
—
0
0
55
394
1.40
1.62
3.5
3.2
0.8
0.8
nmol/l
0.00
45
310
61
445
1.38
1.62
1.1
1.1
1.5
1.5
g/l
0.01
55
396
5
14
3.57
1.61
1.0
1.5
—
—
—
0
0
971
9078
1.09
1.60
3.2
3.2
7.4
7.3
mmol/l
0.33
822
7750
175
1464
1.20
1.59
2.0
2.0
40.4
39.4
u/l
0.25
161
1345
162
1941
0.83
1.59
1.5
1.5
—
—
—
0
0
329
2901
1.15
1.57
1.4
1.5
—
—
—
0
0
1399
13287
1.08
1.57
3.5
3.6
—
—
—
0
0
262
2274
1.16
1.56
2.0
2.1
5351.8
5313.3
u/l
0.01
103
911
116
932
1.25
1.55
1.9
2.2
9.5
11.1
mg/l
1.89
107
873
114
915
1.25
1.54
1.9
2.3
219.7
621.3
ug/l
1.02
105
844
124
1009
1.24
1.50
2.5
2.2
7.4
7.4
g/l
0.16
99
771
124
1009
1.24
1.50
2.5
2.2
—
—
—
0
0
962
9023
1.09
1.47
3.7
3.8
0.0
0.0
estimate
2.17
371
3183
70
532
1.32
1.46
1.1
1.2
—
—
—
0
0
41
285
1.44
1.45
2.0
1.9
19.1
19.4
nmol/l
0.06
36
273
272
2383
1.15
1.44
2.6
3.6
5.9
5.8
kpa
0.29
256
2307
5
16
3.13
1.44
1.0
1.0
—
—
—
0
0
9
39
2.31
1.43
1.1
1.1
—
—
—
0
0
270
2367
1.15
1.42
2.6
3.6
2.0
1.9
mmol/l
0.18
204
1937
123
1008
1.23
1.41
2.5
2.2
3.7
3.7
g/l
0.15
96
728
89
706
1.27
1.36
2.8
3.8
56.7
56.7
%
0.01
89
706
41
289
1.42
1.36
1.2
1.4
—
—
—
0
0
53
391
1.36
1.36
1.3
1.5
—
—
—
0
0
323
2879
1.13
1.34
2.2
2.2
0.2
0.2
g/l
0.80
301
2712
38
266
1.43
1.32
1.1
1.1
1.1
1.0
ratio
0.97
16
100
38
266
1.43
1.32
1.4
1.5
10.4
11.0
umol/l
0.32
38
251
135
1126
1.21
1.31
1.7
1.8
1.5
1.5
g/l
0.33
112
974
48
351
1.37
1.30
1.4
1.5
—
—
—
0
0
46
334
1.38
1.30
1.4
1.4
16.3
12.5
mmol/l
—
9
64
168
1432
1.18
1.29
2.2
2.5
0.3
0.3
e6/l
0.07
160
1374
119
1433
0.83
1.28
2.3
1.9
—
—
—
0
0
305
2720
1.13
1.27
3.6
3.8
24.5
21.0
%
2.65
112
1150
49
362
1.36
1.26
1.4
1.6
50.0
54.9
%
0.37
33
224
352
3169
1.12
1.26
2.6
2.3
42.1
53.2
u/l
0.29
305
2694
160
1367
1.18
1.21
6.9
9.3
24.5
24.3
mmol/l
0.25
150
1284
59
452
1.31
1.21
1.6
1.6
7.5
7.6
mmol/l
0.07
39
281
80
640
1.25
1.18
2.6
2.5
70.0
81.4
ug/min
0.14
55
391
95
775
1.23
1.18
1.7
1.4
17.8
21.0
e6/l
0.15
74
593
95
775
1.23
1.18
1.7
1.4
864.9
1489.2
e6/l
0.54
78
628
138
1171
1.18
1.15
1.3
1.4
—
—
—
0
0
0
35
0.00
1.15
0.0
1.1
—
—
—
0
0
12
65
1.85
1.13
1.2
1.1
—
—
—
0
0
42
310
1.36
1.11
1.2
1.2
—
—
—
0
0
21
135
1.56
1.11
1.0
1.0
—
—
—
0
0
33
234
1.41
1.10
1.0
1.1
—
—
—
0
0
334
3025
1.11
1.10
4.6
4.2
226.6
242.2
u/l
1.57
313
2864
42
311
1.35
1.10
1.2
1.2
—
—
—
0
0
42
312
1.35
1.08
1.2
1.2
—
—
—
0
0
42
312
1.35
1.08
1.2
1.2
—
—
—
0
0
42
313
1.35
1.06
1.2
1.2
—
—
—
0
0
10
52
1.93
1.06
1.0
1.8
—
—
—
0
0
148
1275
1.17
1.05
2.1
2.0
10.5
11.0
nmol/l
0.24
135
1128
115
970
1.19
1.05
2.8
3.5
124.5
1658.6
u/ml
0.85
94
826
37
271
1.37
1.04
1.2
1.2
—
—
—
0
0
28
195
1.44
1.04
1.1
1.1
86.9
92.3
%
0.52
19
151
50
384
1.31
1.04
1.3
1.5
—
—
—
0
0
76
616
1.24
1.03
1.1
1.1
—
—
—
0
0
129
1102
1.18
1.02
1.1
1.2
—
—
—
0
0
30
213
1.41
1.01
1.3
1.2
—
—
—
0
0
42
316
1.33
1.01
1.5
1.6
—
—
—
0
0
186
1636
1.14
1.01
5.4
6.8
25.1
24.9
mmol/l
0.31
186
1628
9
48
1.88
1.00
1.2
1.7
5.0
883790.3
nmol/l
—
9
37
52
405
1.29
0.98
1.5
1.4
270.9
300.7
pmol/l
0.52
41
315
290
2628
1.11
0.97
1.4
1.3
141.6
187.1
u/ml
1.03
272
2440
10
54
1.85
0.96
1.0
1.2
—
—
—
0
0
93
777
1.20
0.96
1.3
1.4
2.4
3.7
ug/l
2.47
84
703
0
32
0.00
0.95
0.0
1.0
—
—
—
0
0
76
922
0.82
0.95
2.2
3.6
1.3
1.4
mmol/l
0.50
76
908
9
51
1.77
0.94
1.1
1.2
—
—
—
0
0
36
268
1.35
0.94
1.4
1.5
36.0
37.4
%
0.07
22
156
23
158
1.46
0.93
1.6
1.6
—
—
—
0
0
23
158
1.46
0.93
1.6
1.6
—
—
—
0
0
23
158
1.46
0.93
1.6
1.6
—
—
—
0
0
226
2026
1.12
0.93
2.6
2.8
0.7
0.7
ug/l
0.37
126
1210
22
150
1.47
0.92
1.3
1.3
—
—
—
0
0
76
626
1.22
0.91
3.4
3.5
5.0
5.0
kpa
0.11
76
619
23
159
1.45
0.91
1.6
1.6
—
—
—
0
0
44
563
0.78
0.89
2.1
3.0
32.7
34.5
umol/l
0.25
35
492
19
127
1.50
0.88
1.1
1.2
—
—
—
0
0
7
128
0.55
0.88
3.1
2.3
116.1
152.1
nmol/l
—
7
111
24
169
1.42
0.87
1.8
2.7
165.8
173.2
umol/l
0.03
13
93
24
169
1.42
0.87
2.2
1.6
—
—
—
0
0
140
1597
0.87
0.86
1.3
1.3
245.2
225.7
miu/ml
0.27
78
797
40
308
1.30
0.85
1.1
1.1
—
—
—
0
0
22
154
1.43
0.83
1.3
1.3
—
—
—
0
0
19
273
0.69
0.82
2.2
2.5
—
—
—
0
0
35
266
1.32
0.82
1.2
1.2
—
6.3
—
0
19
88
746
1.18
0.81
1.0
1.1
1.6
1.7
u/ml
0.02
13
175
8
47
1.70
0.80
1.1
1.0
—
—
—
0
0
18
122
1.48
0.80
1.3
1.3
—
—
—
0
0
18
122
1.48
0.80
1.3
1.3
—
—
—
0
0
15
224
0.67
0.80
1.1
1.2
—
—
—
0
0
84
711
1.19
0.79
1.5
1.6
—
—
—
0
0
195
1755
1.12
0.78
1.5
1.6
278.8
297.9
mu/l
0.44
164
1567
19
131
1.45
0.78
1.6
1.7
—
—
—
0
0
19
131
1.45
0.78
1.6
1.7
—
—
—
0
0
0
27
0.00
0.77
0.0
2.1
—
—
—
0
0
68
566
1.20
0.77
2.4
2.9
8.5
8.4
kpa
0.10
60
524
545
5139
1.07
0.77
2.7
2.5
1.2
1.3
e6/l
0.16
309
2818
6
34
1.77
0.76
1.3
1.2
—
—
—
0
0
82
696
1.18
0.76
1.6
1.8
—
—
—
0
0
321
2968
1.09
0.76
5.6
7.5
1.0
1.1
mmol/l
0.10
251
2305
5
24
2.08
0.74
1.4
1.0
9.3
8.1
mmol/l
—
5
24
19
133
1.43
0.73
1.7
1.7
—
—
—
0
0
156
1393
1.12
0.73
7.3
10.4
—
—
—
0
0
321
2974
1.09
0.73
5.6
7.4
5.1
5.1
kpa
0.29
306
2842
321
2975
1.09
0.72
5.5
7.4
12.7
13.0
kpa
0.44
304
2842
20
142
1.41
0.72
1.1
1.2
—
—
—
0
0
97
842
1.16
0.70
1.6
1.4
0.5
0.4
nmol/l
0.45
72
673
7
41
1.71
0.70
1.1
1.1
—
—
—
0
0
291
2700
1.08
0.66
2.3
2.4
20.8
23.8
au/ml
0.27
14
196
81
698
1.16
0.65
1.9
1.7
8562.6
9606.4
e6/l
0.12
55
506
256
2364
1.09
0.65
5.1
6.8
1.2
1.3
mmol/l
0.22
241
2277
5
29
1.72
0.64
6.0
3.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
67
783
0.85
0.62
4.3
3.5
0.4
0.4
u/ml
0.33
38
446
8
50
1.60
0.61
1.1
1.2
—
—
—
0
0
133
1193
1.12
0.61
2.6
2.9
25.6
25.4
mmol/l
0.42
123
1146
0
20
0.00
0.60
0.0
1.2
—
22.5
—
0
13
19
140
1.36
0.58
1.0
1.0
—
—
—
0
0
39
318
1.23
0.58
1.8
1.6
—
—
—
0
0
100
886
1.13
0.57
1.4
1.3
454.8
489.1
mg/l
0.40
93
850
231
2139
1.08
0.57
1.5
1.7
—
—
—
0
0
912
8811
1.05
0.57
1.5
1.5
—
—
—
0
0
74
645
1.15
0.54
2.4
3.1
24.6
24.8
mmol/l
0.16
64
574
714
7410
0.96
0.51
3.6
3.9
1.0
1.0
kg/l
0.26
129
1083
87
771
1.13
0.51
1.2
1.3
—
—
—
0
0
172
1583
1.09
0.51
2.7
3.0
133.0
128.8
g/l
1.73
166
1537
32
260
1.23
0.51
1.5
1.5
—
—
—
0
0
32
260
1.23
0.51
1.5
1.5
—
—
—
0
0
32
260
1.23
0.51
1.5
1.5
—
—
—
0
0
19
247
0.77
0.50
2.5
3.7
—
—
—
0
0
6
41
1.46
0.50
1.5
1.6
—
—
—
0
0
20
153
1.31
0.50
1.1
1.2
—
—
—
0
0
33
270
1.22
0.49
3.0
3.6
32.5
28.2
mu/l
0.28
33
260
204
1896
1.08
0.48
1.4
1.4
—
—
—
0
0
182
1684
1.08
0.48
1.4
1.5
—
—
—
0
0
7
48
1.46
0.46
1.0
1.0
—
—
—
0
0
13
94
1.38
0.46
1.2
1.1
—
—
—
0
0
87
779
1.12
0.45
1.3
1.2
3.7
3.7
mmol/l
0.29
82
740
19
147
1.29
0.45
1.2
1.7
—
—
—
0
0
52
450
1.16
0.44
3.2
3.0
1.1
1.4
%
0.64
40
355
23
286
0.80
0.44
1.7
2.0
11.2
13.0
%
0.61
12
139
90
809
1.11
0.44
1.6
1.6
—
—
—
0
0
99
895
1.11
0.44
1.1
1.1
3.2
1.1
u/ml
0.59
36
339
30
247
1.22
0.44
1.9
1.3
4.8
5.0
umol/l
0.13
30
231
58
507
1.15
0.44
1.7
1.7
—
—
—
0
0
45
386
1.17
0.43
1.7
1.6
—
—
—
0
0
5
31
1.61
0.43
6.0
3.2
33.0
19.2
mg/l
—
5
31
43
368
1.17
0.42
1.2
1.5
—
—
—
0
0
167
1551
1.08
0.42
1.3
1.4
—
—
—
0
0
64
565
1.13
0.42
2.5
2.4
17.3
16.6
%
0.70
33
276
8
56
1.43
0.42
1.5
1.8
1.2
1.2
mmol/l
—
8
56
79
708
1.12
0.42
1.6
1.6
—
—
—
0
0
45
388
1.16
0.41
1.1
1.1
—
—
—
0
0
151
1399
1.08
0.41
1.5
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
167
1554
1.08
0.41
1.3
1.4
—
—
—
0
0
36
305
1.18
0.40
1.7
2.2
31.9
32.1
pg
0.10
36
305
224
2109
1.07
0.40
2.1
2.2
5.4
6.4
ug/l
0.60
186
1858
167
1556
1.08
0.40
1.3
1.4
—
—
—
0
0
34
287
1.19
0.40
12.2
5.8
7.4
7.1
mmol/l
0.13
27
245
41
352
1.17
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
0.3
—
0
6
166
1548
1.08
0.39
1.3
1.4
—
—
—
0
0
328
3127
1.05
0.39
1.7
1.7
—
—
—
0
0
10
137
0.73
0.39
1.1
1.1
—
—
—
0
0
88
798
1.10
0.39
2.3
2.8
—
—
—
0
0
86
779
1.11
0.38
1.5
1.4
—
—
—
0
0
324
3089
1.05
0.38
1.6
1.7
—
—
—
0
0
29
242
1.20
0.38
1.3
1.4
1935.5
2815.0
e6/l
0.61
24
170
309
2944
1.05
0.38
3.0
3.9
14.2
34.2
ug/l
0.81
231
2278
259
2458
1.06
0.37
6.1
8.3
122.2
121.1
g/l
0.36
246
2370
9
69
1.31
0.37
1.1
1.5
—
—
—
0
0
64
572
1.12
0.37
1.6
1.5
—
—
—
0
0
25
300
0.83
0.36
1.6
1.4
0.9
1.0
g/l
0.56
25
300
113
1042
1.09
0.36
1.5
1.5
—
—
—
0
0
32
272
1.18
0.36
1.2
1.2
—
—
—
0
0
65
583
1.12
0.35
1.1
1.1
117.0
119.0
%
0.19
54
526
85
774
1.10
0.35
1.1
1.2
—
—
—
0
0
32
273
1.17
0.35
3.3
2.8
55.8
56.7
%
0.08
21
183
12
91
1.32
0.33
2.8
4.9
—
—
—
0
0
67
605
1.11
0.33
1.5
1.4
6.7
7.1
mmol/l
0.79
45
438
261
2488
1.05
0.33
1.2
1.3
69.6
43.1
au/ml
—
10
116
41
359
1.14
0.33
1.9
1.8
89.2
90.2
%
0.31
41
354
6
46
1.30
0.33
3.2
2.1
—
—
—
0
0
6
90
0.67
0.32
1.0
1.2
—
—
—
0
0
6
47
1.28
0.32
2.3
1.9
—
—
—
0
0
48
426
1.13
0.32
1.2
1.4
—
—
—
0
0
133
1243
1.07
0.32
1.8
1.8
—
—
—
0
0
18
146
1.23
0.32
1.2
1.7
—
—
—
0
0
32
276
1.16
0.31
1.2
1.2
—
—
—
0
0
18
219
0.82
0.31
1.1
1.2
—
—
—
0
0
27
230
1.18
0.31
1.7
1.5
4.9
5.6
u/l
0.75
19
199
147
1563
0.94
0.31
1.8
1.8
—
—
—
0
0
20
240
0.83
0.30
1.9
1.7
2.7
3.5
mg/l
0.70
20
231
59
533
1.11
0.30
1.4
1.5
—
—
—
0
0
10
75
1.33
0.30
1.1
1.2
—
—
—
0
0
61
672
0.91
0.30
1.2
1.2
—
—
—
0
0
14
174
0.80
0.29
1.1
1.3
—
627.1
—
0
14
47
420
1.12
0.29
1.2
1.4
—
—
—
0
0
8
109
0.73
0.29
1.0
1.2
—
—
—
0
0
49
440
1.12
0.28
1.2
1.5
—
—
—
0
0
356
3688
0.96
0.28
1.8
1.8
—
—
—
0
0
48
431
1.12
0.28
1.2
1.4
—
—
—
0
0
57
517
1.10
0.28
1.3
1.5
—
—
—
0
0
180
1710
1.06
0.28
1.6
1.5
—
—
—
0
0
47
422
1.12
0.27
1.2
1.4
—
—
—
0
0
427
4403
0.97
0.27
2.3
2.1
30.5
29.3
s
2.67
408
4264
139
1312
1.06
0.27
1.8
1.7
—
—
—
0
0
47
423
1.11
0.27
1.2
1.4
—
—
—
0
0
73
673
1.09
0.26
1.2
1.4
172.4
105.7
u/ml
0.53
20
142
19
225
0.84
0.26
2.2
2.6
—
—
—
0
0
19
225
0.84
0.26
1.3
3.1
—
—
—
0
0
35
310
1.13
0.26
1.7
1.7
—
—
—
0
0
47
426
1.10
0.24
1.1
1.1
—
2.2
—
0
5
43
388
1.11
0.24
1.1
1.2
—
—
—
0
0
15
124
1.21
0.24
1.0
1.0
—
—
—
0
0
112
1056
1.06
0.23
1.2
1.1
—
—
—
0
0
110
1166
0.94
0.23
1.6
1.6
0.1
0.3
iu/ml
0.79
24
233
110
1038
1.06
0.23
4.7
5.8
1.8
1.6
%
0.97
102
967
5
39
1.28
0.23
1.0
1.1
—
—
—
0
0
46
419
1.10
0.22
1.2
1.4
—
—
—
0
0
7
95
0.74
0.22
1.0
1.2
—
—
—
0
0
23
200
1.15
0.22
2.0
1.8
—
—
—
0
0
79
739
1.07
0.21
3.6
3.5
28.2
56.1
mg/l
1.95
60
601
13
107
1.22
0.21
1.6
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
—
—
0
0
277
2861
0.97
0.21
1.7
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
66
614
1.08
0.21
2.0
2.3
135.6
130.4
g/l
0.99
48
451
15
177
0.85
0.21
1.2
1.2
228.9
303.4
u/l
0.46
15
164
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
22
192
1.15
0.20
2.0
2.6
43.2
44.7
%
—
10
61
79
741
1.07
0.20
3.5
3.4
22.6
45.0
mg/l
1.89
60
604
79
741
1.07
0.20
1.2
1.3
—
—
—
0
0
10
80
1.25
0.20
1.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
21.8
—
0
6
221
2289
0.96
0.20
6.4
7.4
8.3
8.4
mmol/l
0.15
213
2194
257
2489
1.03
0.19
3.3
3.2
55.8
46.8
u/ml
0.22
246
2409
6
50
1.20
0.19
1.0
1.4
—
—
—
0
0
434
4443
0.97
0.19
1.5
1.7
1.3
1.4
%
1.31
381
3970
112
1065
1.05
0.19
1.1
1.1
—
—
—
0
0
6
53
1.13
0.18
1.3
1.3
—
—
—
0
0
19
216
0.88
0.17
1.7
1.8
—
—
—
0
0
7
62
1.13
0.17
1.1
1.1
—
—
—
0
0
18
205
0.88
0.17
1.1
1.1
1579.4
1505.5
miu/ml
0.09
18
205
225
2183
1.03
0.17
1.3
1.4
—
—
—
0
0
19
167
1.14
0.16
1.2
1.6
—
—
—
0
0
8
69
1.16
0.16
1.1
1.2
—
—
—
0
0
29
263
1.10
0.16
1.2
1.1
—
—
—
0
0
56
597
0.94
0.16
1.3
1.2
3.6
4.3
u/ml
0.26
28
234
77
730
1.06
0.16
1.2
1.2
291.3
260.9
u/ml
0.49
51
461
8
73
1.10
0.15
2.1
2.0
—
—
—
0
0
60
565
1.06
0.15
1.3
1.3
—
—
—
0
0
366
3738
0.98
0.15
5.2
6.0
—
—
—
0
0
12
102
1.18
0.15
1.6
1.4
16.3
17.6
umol/l
0.59
12
91
159
1644
0.97
0.15
6.9
8.8
0.7
0.7
%
0.42
159
1634
156
1613
0.97
0.15
2.0
1.7
3.0
3.8
mg/l
0.83
123
1130
26
236
1.10
0.14
1.5
2.4
913.3
809.0
e6/l
—
9
98
7
86
0.81
0.14
1.7
1.1
—
—
—
0
0
7
88
0.80
0.14
1.3
1.2
113.7
109.2
%
—
7
83
25
275
0.91
0.14
1.7
2.1
—
—
—
0
0
20
221
0.90
0.12
2.6
2.1
3.0
2.1
u/field
—
9
100
26
239
1.09
0.12
1.1
1.1
1.3
1.1
u/l
0.63
12
108
34
317
1.07
0.12
1.1
1.1
231.0
229.8
mg/l
0.01
27
280
10
116
0.86
0.12
1.4
2.0
—
—
—
0
0
10
116
0.86
0.12
3.4
3.2
—
—
—
0
0
15
168
0.89
0.11
3.2
2.2
13.3
184.0
ug/l
0.76
15
154
161
1654
0.97
0.11
6.9
8.8
94.4
94.2
%
0.25
161
1646
39
415
0.94
0.11
1.7
1.7
—
1592.0
—
0
10
157
1613
0.97
0.11
4.6
7.3
24.8
24.5
mmol/l
0.55
144
1500
19
172
1.11
0.11
1.2
1.7
1.9
2.0
umol/l
0.39
19
159
132
1281
1.03
0.11
1.3
1.3
—
—
—
0
0
33
308
1.07
0.11
1.1
1.1
—
—
—
0
0
23
211
1.09
0.11
1.3
1.7
—
—
—
0
0
63
659
0.96
0.11
1.0
1.1
4.3
3.4
u/ml
0.12
15
241
35
329
1.06
0.10
1.3
1.1
42.9
36.4
mg/l
0.30
27
281
55
525
1.05
0.10
1.7
1.6
—
—
—
0
0
5
45
1.11
0.09
1.0
1.1
—
—
—
0
0
5
45
1.11
0.09
2.0
2.7
15.6
15.3
ml/dl
—
5
40
93
960
0.97
0.09
2.2
2.0
0.9
2.1
ug/l
1.65
79
852
70
674
1.04
0.09
2.9
3.5
21.0
23.5
mg/l
0.27
35
408
58
604
0.96
0.09
1.1
1.1
0.7
3.8
u/ml
4.59
19
227
192
1958
0.98
0.09
2.5
3.0
4.5
4.6
kpa
0.47
181
1891
87
843
1.03
0.09
1.9
1.6
—
—
—
0
0
114
1112
1.03
0.08
2.2
2.1
95.6
93.9
%
0.32
102
1019
28
297
0.94
0.08
1.1
1.1
—
—
—
0
0
6
72
0.83
0.07
1.0
1.2
—
—
—
0
0
23
215
1.07
0.07
1.3
1.4
20494.8
84305.5
e6/l
1.03
18
121
524
5194
1.01
0.07
1.9
2.0
—
—
—
0
0
9
101
0.89
0.06
1.4
2.6
—
—
—
0
0
13
119
1.09
0.06
2.1
2.3
—
—
—
0
0
28
267
1.05
0.05
1.4
1.4
29505.1
96640.4
e6/l
0.82
17
181
10
109
0.92
0.04
1.5
1.5
9.9
8.3
ug/l
—
10
109
27
280
0.96
0.03
1.0
1.1
5.4
10.9
iu/ml
—
7
74
103
1016
1.01
0.03
2.8
2.5
3.5
3.6
g/l
0.54
97
961
24
249
0.96
0.02
1.3
1.7
1.3
1.3
promille
0.05
19
190
12
128
0.94
0.02
1.9
1.6
—
—
—
0
0
12
128
0.94
0.02
1.9
1.6
—
—
—
0
0
583
5850
1.00
0.02
2.0
2.1
—
—
—
0
0
60
610
0.98
0.02
1.1
1.1
—
—
—
0
0
24
232
1.03
0.02
1.1
1.3
—
—
—
0
0
11
103
1.07
0.02
1.1
1.1
—
—
—
0
0
62
611
1.01
0.02
2.2
2.3
0.8
0.8
nmol/l
0.05
48
520
53
538
0.98
0.01
1.0
1.1
0.2
0.3
u/ml
—
7
115
60
592
1.01
0.01
1.3
1.3
—
—
—
0
0
60
592
1.01
0.01
1.3
1.3
—
—
—
0
0
64
632
1.01
0.01
5.3
5.4
181.2
325.9
iu/ml
—
6
79
13
124
1.05
0.00
1.2
1.3
160.7
52.0
pmol/l
—
7
39
391
3918
1.00
0.00
1.6
1.6
—
—
—
0
0
62
614
1.01
0.00
1.2
1.2
2.8
3.6
u/ml
0.34
25
189
10
102
0.98
0.00
1.1
1.0
—
—
—
0
0
10
102
0.98
0.00
1.1
1.1
—
—
—
0
0
22
222
0.99
0.00
1.0
1.4
18.5
7.8
ug/l
0.37
16
190
26
258
1.01
0.00
1.2
1.4
1.2
1.5
nmol/l
0.75
21
234
12
125
0.96
0.00
1.0
1.1
—
—
—
0
0
12
125
0.96
0.00
1.1
1.2
—
—
—
0
0
22
225
0.98
0.00
1.5
1.6
—
—
—
0
0
26
265
0.98
0.00
1.5
1.3
—
—
—
0
0
48
485
0.99
0.00
1.2
1.1
—
—
—
0
0
16
157
1.02
0.00
1.3
1.6
—
1061839.1
—
0
11
10
101
0.99
0.00
1.1
1.1
—
—
—
0
0
33
331
1.00
0.00
1.2
1.3
20.5
32.6
nmol/l
2.18
28
298
335
3346
1.00
0.00
5.7
6.7
105.0
104.6
mmol/l
0.82
330
3275
31
314
0.99
0.00
1.2
1.1
—
—
—
0
0
60
603
0.99
0.00
1.2
1.1
—
—
—
0
0
7
73
0.96
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.2
—
0
5
0
5
0.00
0.00
0.0
6.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
6.9
—
0
7
5
54
0.93
0.00
1.2
1.4
—
—
—
0
0
8
82
0.98
0.00
1.5
4.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
6
66
0.91
0.00
1.5
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
9
90
1.00
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
4.8
—
357.6
—
0
9
0
9
0.00
0.00
0.0
2.2
—
—
—
0
0
8
82
0.98
0.00
1.5
4.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
83
0.96
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
0.00
1.1
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_GRAVES_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_STRICT | 1.07 [0.94, 1.22] | 0.294 |
| Birth year | 0.992 [0.98, 1.0] | 0.082 |
During the follow-up period (1.1.1998 — 31.12.2019), 1142 out of 16342 females with E4_GRAVES_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GRAVES_STRICT | 1.036 [0.89, 1.21] | 0.654 |
| Birth year | 0.991 [0.98, 1.0] | 0.053 |
During the follow-up period (1.1.1998 — 31.12.2019), 345 out of 3489 males with E4_GRAVES_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have E4_GRAVES_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.062% | 0.176% |
| 5 | 0.599% | 1.156% |
| 10 | 1.414% | 3.262% |
| 15 | 2.705% | 6.508% |
| 20 | 4.747% | 11.059% |
Relationships between endpoints
↥Index endpoint: E4_GRAVES_STRICT – Graves disease, strict definition
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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