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Gout, strict definition

GOUT_STRICT

gout: A condition characterized by painful swelling of the joints, which is caused by deposition of urate crystals.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions

GOUT_IDIOP_NOS

7622

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Check pre-conditions, main-only, mode, registry filters

Medicine purchases: ATC M04AA01|M04AA03|M04AB01|M04AB03

1 out of 7 registries used, show all original rules.

5336

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Check minimum number of events

Min. number of events 3

5336

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Include endpoints None

5336

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Remove individuals based on genotype QC

5162

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GOUT_STRICT

Control definitions

Control conditions not GOUT_IDIOP_NOS

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 5162 1054 4108
Unadjusted prevalence (%) 1.25 0.46 2.26
Mean age at first event (years) 62.42 65.70 61.58

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.07 [1.64, 2.61] 1.1e-9 1319
15 years 0.01 1.58 [1.30, 1.92] 4.3e-6 658
5 years 0.00 2.53 [2.13, 3.00] 5.5e-26 341
1 year 0.00 1.73 [1.25, 2.40] 1.0e-3 44

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: GOUT_STRICT – Gout, strict definition
GWS hits: 10

Survival analyses between endpoints

Plot

before Gout, strict definition
after Gout, strict definition

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Drugs most likely to be purchased after Gout, strict definition

Endpoint not on priority list, no data to show.