Retinal breaks without detachment

H7_RETINALBREAK

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H33.3
  • Hospital discharge: ICD-9 3613
  • Cause of death: ICD-10 H33.3
  • Cause of death: ICD-9 3613

2 out of 7 registries used, show all original rules.

6936

4. Check minimum number of events

None

6936

5. Include endpoints

None

6936

6. Filter based on genotype QC (FinnGen only)

6729

Control definitions (FinnGen only)

Control exclude
H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H33
Name in latin
Ruptura retinae sine ablatione

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 37057 20151 16809
Only index persons 36278 19857 16421
Unadjusted period prevalence (%)
Whole population 0.53 0.58 0.47
Only index persons 0.68 0.73 0.63
Median age at first event (years)
Whole population 60.88 60.16 61.81
Only index persons 60.82 60.09 61.71

-FinnGen-

Key figures

All Female Male
Number of individuals 6729 3801 2928
Unadjusted period prevalence (%) 1.35 1.35 1.34
Median age at first event (years) 61.41 59.80 63.49

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
6936
Matched controls
69360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
76.2
319.0
171
23
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.4
309.8
848
2116
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
329.9
307.7
404
13
H43.8
ICD-10 Finland
Other disorders of vitreous body
7.5
307.7
2042
3649
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
61.4
307.7
266
45
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
78.6
307.7
206
27
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
44.4
307.7
472
114
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
238.6
307.7
297
13
H33.3
ICD-10 Finland
Retinal breaks without detachment
772246.3
307.7
6905
20
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.4
307.7
1079
2808
CKD40
NOMESCO Finland
Endophotocoagulation of retina
804.5
307.7
381
5
H33.0
ICD-10 Finland
Retinal detachment with retinal break
2942.0
307.7
1273
5
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.6
307.7
1269
4046
WX140
NOMESCO Finland
Parabulbar anesthesy
17.8
307.7
820
519
H35.4
ICD-10 Finland
Peripheral retinal degeneration
279.1
307.7
294
11
H43.1
ICD-10 Finland
Vitreous haemorrhage
31.2
307.7
767
275
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
56.3
307.7
373
70
CKC10
NOMESCO Finland
Local photocoagulation of retina
493.1
307.7
787
18
CKC12
NOMESCO Finland
Photocoagulation of retina
1387.8
307.7
4119
73
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
63.3
307.7
297
49
H33.5
ICD-10 Finland
Other retinal detachments
35.3
307.7
229
67
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
44.6
293.8
174
40
H26.4
ICD-10 Finland
After-cataract
3.6
246.4
915
2818
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.3
218.8
2677
15089
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.3
213.5
2370
12803
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.6
209.0
749
2244
H34.8
ICD-10 Finland
Other retinal vascular occlusions
57.9
203.2
114
20
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
9.3
199.1
242
268
H33
ICD-10 Finland
Retinal detachments and breaks
58.8
196.6
110
19
H52.1
ICD-10 Finland
Myopia
5.4
196.0
398
768
CKC15
NOMESCO Finland
Panretinal photocoagulation
100.4
191.0
99
10
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
187.3
179
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.1
177.4
517
1337
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.4
165.7
1404
6654
S01ED51
ATC
timolol, combinations; ophthalmic
3.3
164.8
680
2217
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
536.9
159.5
158
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.0
158.8
3314
22058
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
153.7
147
*
XCH00
NOMESCO Finland
Eye pressure measurement
3.9
144.0
446
1202
H53.1
ICD-10 Finland
Subjective visual disturbances
2.9
126.5
629
2274
H26.2
ICD-10 Finland
Complicated cataract
8.7
125.1
159
186
H25.1
ICD-10 Finland
Senile nuclear cataract
2.0
124.8
1845
10722
CKD20
NOMESCO Finland
Removal of vitreous body substitute
619.1
123.7
122
*
H35.37
ICD-10 Finland
Macular holes
315.8
121.7
123
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
299.6
115.5
117
*
S01EA03
ATC
apraclonidine; ophthalmic
11.2
109.1
115
104
H43.9
ICD-10 Finland
Disorder of vitreous body, unspecified
7.4
105.7
155
215
H33.1
ICD-10 Finland
Retinoschisis and retinal cysts
269.9
104.1
106
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
96.0
92
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
238.2
91.7
94
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.4
90.2
342
1050
CKD15
NOMESCO Finland
Injection of vitreous substitute
890.0
90.0
88
*
Z2221
NOMESCO Finland
Medical doctor
1.8
89.0
1930
12437
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.1
87.7
907
4569
XCD20
NOMESCO Finland
Photoangiography of eye
15.6
85.4
74
48
XCK10
NOMESCO Finland
Photography of fundus of eye
2.4
81.7
622
2758
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
16.9
80.6
67
40
WX142
NOMESCO Finland
Sub-tenon anesthesy
12.9
76.8
74
58
ZXA05
NOMESCO Finland
Left side
1.7
68.4
1714
11351
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
8.9
67.8
84
95
H26.02
ICD-10 Finland
Presenil cataract
3.4
67.2
250
758
S01ED01
ATC
timolol; ophthalmic
3.4
67.0
253
774
H43.3
ICD-10 Finland
Other vitreous opacities
4.5
63.3
157
357
H35.7
ICD-10 Finland
Separation of retinal layers
211.9
61.2
63
*
H43
ICD-10 Finland
Disorders of vitreous body
7.1
60.4
91
130
WX002
NOMESCO Finland
Sedation and analgesia
1.7
60.1
1360
8725
ZXA00
NOMESCO Finland
Right side
1.6
59.3
1820
12606
S01EC01
ATC
acetazolamide; systemic
4.1
57.0
156
383
H25.8
ICD-10 Finland
Other senile cataract
2.0
55.4
697
3738
ZXA10
NOMESCO Finland
Bilateral
1.7
51.5
1160
7402
H35.36
ICD-10 Finland
Macular cyst
174.6
49.9
52
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.6
48.1
285
1120
H35.6
ICD-10 Finland
Retinal haemorrhage
104.8
47.8
52
5
S01EE01
ATC
latanoprost; ophthalmic
2.2
46.1
400
1864
XCD10
NOMESCO Finland
Electrophysiological examination of eye
3.5
45.1
154
442
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
+∞
44.8
43
*
S01EA05
ATC
brimonidine; ophthalmic
3.3
43.0
165
510
H20.1
ICD-10 Finland
Chronic iridocyclitis
5.3
42.8
86
164
CKC65
NOMESCO Finland
Removal of buckling implant from sclera
+∞
42.7
41
*
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
42.6
764
4562
S01BC05
ATC
ketorolac; ophthalmic
2.8
42.2
222
821
114
Kela drug reimbursment
Glaucoma
1.9
41.7
527
2822
A98
ICPC
Health maint/preventive medicine
2.4
40.5
6703
63949
F29
ICPC
Eye symptom/complaint other
1.8
39.1
614
3523
H33.4
ICD-10 Finland
Traction detachment of retina
201.1
38.8
40
*
H33.2
ICD-10 Finland
Serous retinal detachment
82.6
36.8
41
5
S01EC04
ATC
brinzolamide; ophthalmic
2.4
36.6
251
1057
H25.0
ICD-10 Finland
Senile incipient cataract
2.0
36.6
430
2244
H3601, E113,
ICD-10 Finland
+∞
36.5
35
*
H44.2
ICD-10 Finland
Degenerative myopia
13.8
35.6
33
24
H3600, E113,
ICD-10 Finland
+∞
35.4
34
*
3613A
ICD-9 Finland
Retinal detachments and defects, Retinal defects without detachment
+∞
35.4
34
*
F05
ICPC
Visual disturbance other
2.6
35.1
209
824
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
7.8
33.6
46
59
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
170.8
32.7
34
*
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
6.6
32.7
52
79
H3603, E103,
ICD-10 Finland
+∞
32.3
31
*
H3600, E103,
ICD-10 Finland
+∞
31.3
30
*
H3603, E113,
ICD-10 Finland
+∞
31.3
30
*
F04
ICPC
Visual floaters/spots
5.2
30.7
62
119
CKD50
NOMESCO Finland
Endodiathermy of retina
+∞
30.2
29
*
H40.0
ICD-10 Finland
Glaucoma suspect
1.7
29.0
508
3001
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
150.6
28.7
30
*
H57.1
ICD-10 Finland
Ocular pain
2.3
28.5
225
1009
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
28.4
1152
8293
XCK00
NOMESCO Finland
Perimetry
1.9
28.2
362
1946
H30.2
ICD-10 Finland
Posterior cyclitis
282.7
27.8
28
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
32.9
27.7
36
11
R01AD09
ATC
mometasone; nasal
1.3
27.4
2772
23167
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.9
27.3
79
203
H53
ICD-10 Finland
Visual disturbances
4.3
27.1
70
165
H27.1
ICD-10 Finland
Dislocation of lens
7.7
26.8
37
48
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
23.2
26.0
37
16
ZXE00
NOMESCO Finland
One hour or less
1.3
25.6
2316
18993
CS494
NOMESCO Finland
Other visual field testing
2.5
24.7
160
657
H35.8
ICD-10 Finland
Other specified retinal disorders
32.1
24.6
32
10
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.6
24.2
79
221
H53.8
ICD-10 Finland
Other visual disturbances
3.1
24.0
100
326
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
37.7
23.9
30
8
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
240.8
23.7
24
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
8.8
22.4
28
32
S01BC03
ATC
diclofenac; ophthalmic
2.6
22.3
126
485
H3601, E103,
ICD-10 Finland
+∞
21.9
21
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
6.7
21.6
34
51
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
1.9
20.7
257
1366
H36.01
ICD-10 Finland
Diabetic maculopathy
22.4
20.3
29
13
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
20.1
2193
18298
R01AD08
ATC
fluticasone; nasal
1.3
19.9
1679
13532
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
20.8
19.9
29
14
S01EE05
ATC
tafluprost; ophthalmic
2.0
19.8
215
1091
H34.2
ICD-10 Finland
Other retinal artery occlusions
46.1
19.2
23
5
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
1.7
19.1
350
2093
S01EC54
ATC
brinzolamide, combinations; ophthalmic
3.0
19.1
82
273
A02BC05
ATC
esomeprazole; systemic
1.3
19.0
2578
22066
H35.9
ICD-10 Finland
Retinal disorder, unspecified
15.9
18.7
30
19
H34.1
ICD-10 Finland
Central retinal artery occlusion
70.1
18.7
21
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
2.0
18.7
196
984
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
5.6
18.2
34
61
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
33.0
17.9
23
7
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
5.8
17.9
32
55
N40
ICD-10 Finland
Hyperplasia of prostate
1.3
17.2
1262
9944
J01FA10
ATC
azithromycin; systemic
1.2
16.8
3424
30532
CKD25
NOMESCO Finland
External drainage of subretinal fluid
+∞
16.7
16
*
H31.0
ICD-10 Finland
Chorioretinal scars
90.3
16.6
18
*
H21.0
ICD-10 Finland
Hyphaema
5.9
16.5
29
49
ZXD10
NOMESCO Finland
Scheduled procedure
1.3
16.4
2298
19643
Z3231
NOMESCO Finland
Registered nurse
1.3
16.2
1552
12675
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
16.1
1702
14070
L82
ICD-10 Finland
Seborrhoeic keratosis
1.3
15.8
1122
8792
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
2.6
15.8
93
367
3745
FHL
Hard membrane girding, cerclage with coagulation
60.1
15.7
18
*
XCW10
NOMESCO Finland
Assessment of vision
3.0
15.7
68
228
A10AA01, ,
ATC
2.9
15.7
70
239
CKC75
NOMESCO Finland
Removal of cerclage from sclera
+∞
15.6
15
*
1LA05, ,
NOMESCO Finland
+∞
15.6
15
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
15.5
1555
12760
R01AD12
ATC
fluticasone furoate; nasal
1.3
15.1
1717
14299
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.2
15.1
2814
24759
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.3
14.8
1572
12976
A02BC02
ATC
pantoprazole; systemic
1.2
14.8
4380
40364
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
1.5
14.3
462
3161
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
1.9
14.2
188
1024
S01EE03
ATC
bimatoprost; ophthalmic
2.2
14.0
118
546
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
5.8
14.0
25
43
ZXD20
NOMESCO Finland
Day surgery
1.4
14.0
719
5357
Z71.8
ICD-10 Finland
Other specified counselling
1.3
13.6
1674
14043
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.3
13.6
1338
10931
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
2.1
13.5
124
594
J02AC01
ATC
fluconazole; systemic
1.2
13.4
2243
19446
S01KA02
ATC
hypromellose; ophthalmic
2.2
13.3
105
473
M01AH05
ATC
etoricoxib; oral
1.2
13.3
3931
36023
CK2Y4
NOMESCO Finland
OCT video recording of ocular fundus
40.1
13.1
16
*
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
3.1
13.1
52
166
R01BA52
ATC
pseudoephedrine, combinations; oral
1.2
13.1
1820
15463
M79.6
ICD-10 Finland
Pain in limb
1.2
13.0
2478
21743
A10AA02, ,
ATC
2.5
13.0
82
335
H53.4
ICD-10 Finland
Visual field defects
2.2
13.0
109
504
S01FA04
ATC
cyclopentolate; ophthalmic
2.7
12.6
68
258
CKD30
NOMESCO Finland
Internal drainage of subretinal fluid
+∞
12.5
12
*
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
130.2
12.4
13
*
R5140
NOMESCO Finland
Monitoring the use of the aid
1.4
12.2
635
4734
G47.3
ICD-10 Finland
Sleep apnoea
1.3
12.2
1367
11323
A10AB01
ATC
insulin (human); parenteral
2.3
12.2
93
414
J01CA04
ATC
amoxicillin; systemic
1.2
12.1
5068
47793
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.2
11.8
1990
17211
M03BX02
ATC
tizanidine; oral
1.2
11.8
3864
35556
Z3229
NOMESCO Finland
Other healthcare associate professional
1.5
11.7
412
2867
G04CA01
ATC
alfuzosin; oral
1.3
11.7
704
5370
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
2.7
11.7
59
216
S01BA07
ATC
fluorometholone; ophthalmic
2.3
11.7
89
396
R01AD01
ATC
beclometasone; nasal
1.3
11.7
843
6602
H04AA01
ATC
glucagon; nasal, parenteral
2.8
11.6
56
200
H52.3
ICD-10 Finland
Anisometropia and aniseikonia
2.9
11.6
53
184
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
11.5
3054
27548
3747
FHL
Combined ablation and vitreous surgery with coagulation
120.2
11.4
12
*
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
120.2
11.4
12
*
R42
ICD-10 Finland
Dizziness and giddiness
1.3
11.2
1243
10272
R05
ICD-10 Finland
Cough
1.3
11.2
1206
9934
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
11.2
2469
21889
M01AE02
ATC
naproxen; oral, rectal
1.2
11.1
3348
30505
S01EE04
ATC
travoprost; ophthalmic
2.1
11.0
100
478
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.3
11.0
710
5472
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
2.6
11.0
61
235
J31.0
ICD-10 Finland
Chronic rhinitis
1.4
10.9
441
3152
CM2S4
NOMESCO Finland
Follow-up photography of age-related macular degeneration lesions
11.9
10.8
19
16
M01AB05
ATC
diclofenac; systemic, rectal
1.2
10.8
4168
38753
DFF00
NOMESCO Finland
Pure tone audiometry
1.4
10.8
566
4227
F28
ICPC
Limited function/disability (F)
3.3
10.6
38
114
J01DB01
ATC
cefalexin; oral
1.2
10.5
5258
49981
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.4
10.5
567
4254
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.3
10.5
686
5298
Z01.2
ICD-10 Finland
Dental examination
1.2
10.4
2572
22985
H3602, E103,
ICD-10 Finland
+∞
10.4
10
*
S01BA01
ATC
dexamethasone; ophthalmic
1.7
10.3
181
1073
H26.9
ICD-10 Finland
Cataract, unspecified
2.1
10.3
94
451
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
5.1
10.3
21
41
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
4.7
10.2
23
49
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.3
10.2
1105
9101
L03
ICPC
Low back symptom/complaint
1.2
10.2
1509
12856
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.3
10.2
1133
9363
J01AA02
ATC
doxycycline; systemic
1.2
10.1
5007
47426
L57
ICPC
Musculoskeletal, Physical medicine/rehabilitation
4.1
10.1
27
66
A10BA02
ATC
metformin; oral
0.8
10.1
1176
14033
J01FA09
ATC
clarithromycin; systemic
1.2
10.1
1776
15388
WX110
NOMESCO Finland
Infiltration anesthesia
1.2
10.0
4308
40297
WX408
NOMESCO Finland
General anesthesy, balanced
1.2
9.9
1481
12618
U07.2
ICD-10 Finland
COVID-19, virus not identified
1.3
9.9
808
6430
C05AA08
ATC
fluocortolone; rectal, topical
1.3
9.8
773
6119
EB1SA, ,
SPAT
1.5
9.8
260
1707
F43
ICPC
Eye, Other diagnostic procedure
2.0
9.8
109
563
G04CA02
ATC
tamsulosin; oral
1.2
9.7
1291
10874
A10AB04
ATC
insulin lispro; parenteral
2.1
9.7
93
456
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.3
9.6
666
5183
A06AC51
ATC
ispaghula, combinations; oral
1.5
9.6
256
1686
H36.02
ICD-10 Finland
Preproliferative diabetic retinopathy
100.2
9.4
10
*
H30.8
ICD-10 Finland
Other chorioretinal inflammations
+∞
9.4
9
*
TCK00
NOMESCO Finland
Photosensitisation of choroid and retina
+∞
9.4
9
*
CKD75
NOMESCO Finland
Retinotomy
+∞
9.4
9
*
3759
FHL
Other measure in this category
+∞
9.4
9
*
H30.0
ICD-10 Finland
Focal chorioretinal inflammation
+∞
9.4
9
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
1.4
9.2
346
2440
R06AX27
ATC
desloratadine; oral
1.2
9.2
1481
12703
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
1.6
9.2
213
1359
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
9.2
2301
20538
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.3
9.1
757
6036
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.5
9.1
286
1950
F01
ICPC
Eye pain
1.8
9.1
138
788
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.2
9.0
1071
8904
F82
ICPC
Detached retina
36.7
9.0
11
*
F38
ICPC
Eye, Other laboratory test NEC
2.2
9.0
72
329
H11.3
ICD-10 Finland
Conjunctival haemorrhage
1.5
8.9
229
1497
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
2.0
8.8
88
438
Z01.7
ICD-10 Finland
Laboratory examination
1.3
8.8
760
6090
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
2.4
8.8
55
226
N05CF02
ATC
zolpidem; oral
1.2
8.7
951
7828
J01MA02
ATC
ciprofloxacin; systemic
1.2
8.7
2257
20181
N02BE01
ATC
paracetamol; systemic, rectal
1.2
8.6
5812
56071
D07AC13
ATC
mometasone; topical
1.2
8.6
1616
14051
S29
ICPC
Skin symptom/complaint other
1.2
8.6
1038
8646
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
90.2
8.4
9
*
S01AA01
ATC
chloramphenicol; ophthalmic
1.5
8.4
240
1605
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
1.4
8.3
399
2937
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
2.0
8.3
83
413
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
6.7
8.3
20
30
M25.5
ICD-10 Finland
Pain in joint
1.2
8.3
1812
15951
37600
ICD-8 Finland
Detachment of retina, Primaria
+∞
8.3
8
*
H3602, E113,
ICD-10 Finland
+∞
8.3
8
*
WX320
NOMESCO Finland
Spinalanesthesy
1.2
8.3
1381
11867
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
3.7
8.3
25
67
K07.60
ICD-10 Finland
Snapping jaw
1.5
8.3
234
1560
R03BA05
ATC
fluticasone; inhalant
1.2
8.3
937
7747
H40.9
ICD-10 Finland
Glaucoma, unspecified
2.0
8.3
81
401
M01AX05
ATC
glucosamine; oral
1.2
8.2
1132
9552
K03.64
ICD-10 Finland
Dental calculus supragingival
1.2
8.1
1631
14254
L57.0
ICD-10 Finland
Actinic keratosis
1.3
8.1
559
4348
CA1ME
NOMESCO Finland
Ultrasound oculometry
3.1
8.1
32
103
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
3.2
8.1
31
98
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
3.4
8.1
28
83
L15
ICPC
Knee symptom/complaint
1.2
8.0
1342
11539
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.2
8.0
2557
23197
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
8.0
2754
25125
D22
ICD-10 Finland
Melanocytic naevi
1.5
8.0
233
1567
G04BD12
ATC
mirabegron; oral
1.3
7.9
651
5181
S82
ICPC
Naevus/mole
1.3
7.9
693
5559
SHA01
NOMESCO Finland
Stomatognathic treatment, simple
1.3
7.8
519
4014
UJF30
NOMESCO Finland
Ileoscopy through colon
1.3
7.8
547
4262
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
1.8
7.8
119
682
R49.03
ICD-10 Finland
Atrophic dysphonia
2.2
7.8
63
290
R4110
NOMESCO Finland
Physiotherapy
1.2
7.7
1580
13827
D01AE16
ATC
amorolfine; topical
1.3
7.7
637
5076
H40.8
ICD-10 Finland
Other glaucoma
3.5
7.7
25
71
CS2P4
NOMESCO Finland
Optic nerve head imaging
2.5
7.6
46
186
A02BC04
ATC
rabeprazole; oral
1.3
7.5
459
3511
A97
ICPC
No disease
1.2
7.5
914
7612
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
2.6
7.5
42
164
L04AD02
ATC
tacrolimus; systemic
2.4
7.5
48
200
ZX198
NOMESCO Finland
Other local administration
3.0
7.4
31
103
XKD00
NOMESCO Finland
Uroflowmetry
1.2
7.4
852
7049
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
1.4
7.4
273
1921
R74
ICPC
Upper respiratory infection acute
1.2
7.4
1497
13084
R06AE07
ATC
cetirizine; oral
1.2
7.3
2445
22218
H35.1
ICD-10 Finland
Retinopathy of prematurity
+∞
7.3
7
*
H30.9
ICD-10 Finland
Chorioretinal inflammation, unspecified
+∞
7.3
7
*
3742
FHL
Cryocoagulation under general anesthesia
+∞
7.3
7
*
J05AB11
ATC
valaciclovir; oral
1.2
7.3
753
6160
S01FA01
ATC
atropine; ophthalmic
4.1
7.3
19
46
H93.1
ICD-10 Finland
Tinnitus
1.4
7.2
372
2772
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
0.8
7.2
963
11381
H02
ICPC
Hearing complaint
1.3
7.2
738
6028
CFB00
NOMESCO Finland
Suture of conjunctiva
6.2
7.2
18
29
Z94.0
ICD-10 Finland
Kidney transplant status
2.3
7.2
51
222
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
3.7
7.2
22
60
M79.1
ICD-10 Finland
Myalgia
1.3
7.2
722
5889
H36.09
ICD-10 Finland
Diabetic retinopathy (E10-E14+ with common fourth character .3)
30.0
7.1
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.2
7.1
1945
17398
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
7.1
2583
23592
R83
ICPC
Respiratory infection other
1.2
7.1
1151
9855
SDA03
NOMESCO Finland
Periodontal treatment
1.2
7.1
2247
20322
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
1.4
7.1
324
2369
H35
ICD-10 Finland
Other retinal disorders
12.0
7.1
12
10
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
1.4
7.1
303
2193
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
2.3
7.1
50
218
H02AB04
ATC
methylprednisolone; systemic
1.2
7.0
766
6305
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.2
7.0
918
7705
D07AB02
ATC
hydrocortisone butyrate; topical
1.2
6.9
1581
13941
M01AH01
ATC
celecoxib; oral
1.2
6.9
1011
8573
H02AB07
ATC
prednisone; oral
1.2
6.9
719
5887
S21
ICPC
Skin texture symptom/complaint
1.2
6.8
742
6101
G04CB01
ATC
finasteride; oral
1.3
6.8
531
4201
C07AA05
ATC
propranolol; systemic
1.2
6.8
1031
8776
H40
ICD-10 Finland
Glaucoma
2.2
6.7
51
229
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
0.7
6.7
269
3708
H01.0
ICD-10 Finland
Blepharitis
1.4
6.7
292
2118
R03BA02
ATC
budesonide; inhalant
1.2
6.7
915
7704
CKD60
NOMESCO Finland
Anterior vitrectomy
2.7
6.7
35
132
H54.5
ICD-10 Finland
Severe visual impairment, monocular
3.1
6.7
26
83
R03BC03
ATC
nedocromil; inhalant
1.4
6.7
351
2628
R03AC02
ATC
salbutamol; inhalant
1.1
6.6
3143
29194
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
1.4
6.6
231
1613
J01FA06
ATC
roxithromycin; oral
1.1
6.6
2271
20643
M02AA07
ATC
piroxicam; topical
1.2
6.6
2092
18909
H61.2
ICD-10 Finland
Impacted cerumen
1.4
6.6
333
2479
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
2.0
6.6
70
359
D06BB10
ATC
imiquimod; topical
1.4
6.6
237
1665
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.1
6.5
2614
24001
M01AE01
ATC
ibuprofen; systemic, rectal
1.2
6.5
5820
56462
R01AD58
ATC
fluticasone, combinations; nasal
1.2
6.5
1203
10419
S18
ICPC
Laceration/cut
1.1
6.5
2713
24980
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
0.7
6.4
164
2452
UKC02
NOMESCO Finland
Cystoscopy
1.2
6.4
846
7102
H52.2
ICD-10 Finland
Astigmatism
1.9
6.3
79
427
N17
ICPC
Vertigo/dizziness
1.3
6.3
591
4779
H43.0
ICD-10 Finland
Vitreous prolapse
5.2
6.3
18
35
H20.8
ICD-10 Finland
Other iridocyclitis
3.2
6.3
24
76
E0000UV, ,
ATC
1.1
6.3
2265
20640
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
6.2
6
*
SFA20
NOMESCO Finland
Two-surface restoration
1.1
6.2
3383
31647
S83.2
ICD-10 Finland
Tear of meniscus, current
1.3
6.2
360
2734
SDA04
NOMESCO Finland
Demanding periodontal treatment
1.2
6.2
1479
13072
GD1AA, ,
SPAT
1.3
6.2
532
4260
M01AH02
ATC
rofecoxib; oral
1.2
6.2
686
5657
C09CA06
ATC
candesartan; oral
1.2
6.2
1320
11571
R06AE09
ATC
levocetirizine; oral
1.2
6.1
696
5750
N02AJ06
ATC
codeine and paracetamol; systemic
1.1
6.1
2428
22254
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
0.7
6.1
158
2355
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
2.5
6.1
35
139
N02CC04
ATC
rizatriptan; oral
1.4
6.1
241
1723
H81
ICPC
Excessive ear wax
1.2
6.1
909
7724
J05AB01
ATC
aciclovir; systemic
1.2
6.1
1142
9904

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
6766
64954
2.70
38.03
21.8
21.4
6.48
6.66
e9/l
6.96
6598
63090
6767
64971
2.70
37.97
21.9
21.5
136.07
135.60
g/l
1.98
6683
64107
6765
64955
2.68
37.73
21.7
21.3
91.24
91.33
fl
1.10
6679
64090
6765
64960
2.68
37.63
21.8
21.4
4.50
4.49
e12/l
2.19
6588
63121
6763
64951
2.65
37.25
21.7
21.3
30.38
30.40
pg
0.33
6677
64083
6761
64930
2.64
37.11
21.8
21.4
245.06
249.86
e9/l
8.16
6610
63288
6756
64879
2.59
36.73
21.9
21.5
40.26
40.40
%
0.52
6399
60609
4921
44082
1.40
33.69
4.3
4.1
11.13
12.48
mm/h
10.58
4522
40812
6373
60178
1.73
33.32
5.3
5.1
2.75
2.78
mmol/l
1.34
5841
55485
6595
62931
1.98
33.15
11.2
10.8
25.79
26.58
u/l
3.13
6340
60787
6271
59015
1.65
32.56
4.8
4.6
4.67
4.70
mmol/l
1.18
5752
54709
6234
58602
1.63
32.24
4.7
4.5
1.49
1.48
mmol/l
2.36
5692
54001
5809
54067
1.46
28.35
5.0
4.7
1.91
2.18
mu/l
2.26
5264
49454
6568
62898
1.83
28.07
17.2
17.1
78.07
77.06
umol/l
1.80
6563
62878
6038
56662
1.51
27.93
4.2
4.1
1.24
1.31
mmol/l
11.77
5470
51744
6173
58248
1.54
27.32
4.8
4.7
5.86
5.95
mmol/l
7.50
5591
53218
2932
24971
1.30
24.26
2.2
2.1
—
—
—
0
0
6440
61640
1.63
23.58
16.7
16.7
3.96
3.97
mmol/l
4.71
6263
60169
6184
58674
1.50
23.42
14.4
14.4
22.63
24.23
mg/l
2.97
4774
46656
6419
61480
1.59
22.35
16.5
16.5
139.86
139.77
mmol/l
2.44
6259
60114
2740
23403
1.28
21.22
2.9
2.8
134.54
147.04
ug/l
1.27
2507
21627
6359
60869
1.54
21.13
13.5
13.6
—
—
—
0
0
3163
27549
1.27
20.74
6.2
6.1
2.97
2.87
%
1.70
2964
25694
5875
55446
1.39
20.71
5.8
5.7
39.12
39.68
mmol/mol
5.51
5383
51267
3073
26681
1.27
20.64
6.2
6.1
0.71
0.68
%
1.62
2873
24832
3197
27937
1.27
20.19
6.1
6.0
57.03
57.13
%
0.19
3004
26123
3236
28329
1.27
20.09
6.3
6.2
27.92
27.81
%
0.24
3039
26526
3171
27693
1.27
20.09
6.4
6.4
8.79
8.66
%
1.39
2970
25879
4866
44796
1.29
19.72
4.1
4.0
14.79
14.82
pmol/l
0.44
4388
40791
4410
40193
1.27
18.90
4.4
4.3
—
—
—
0
0
2791
24199
1.26
18.15
2.3
2.2
81.50
78.22
nmol/l
7.31
2485
21762
5018
46632
1.28
17.37
7.7
7.8
77.36
78.44
u/l
0.85
4731
44051
1484
11984
1.30
16.95
3.4
3.1
0.74
0.76
ug/l
0.42
1021
8232
577
4087
1.45
14.96
2.1
2.2
12.78
12.69
nmol/l
0.10
522
3631
3362
30231
1.22
14.22
6.1
5.9
1.87
1.93
e9/l
0.87
2946
26532
3106
27728
1.22
14.07
6.5
6.4
—
—
—
0
0
3288
29558
1.21
13.76
6.0
5.8
0.04
0.04
e9/l
1.28
2824
25339
3277
29475
1.21
13.56
6.1
5.8
0.58
0.59
e9/l
1.86
2813
25280
978
7697
1.32
13.17
4.6
4.6
32.77
32.38
%
0.53
668
5241
3381
30572
1.21
13.02
6.3
6.1
0.19
0.19
e9/l
0.08
2943
26654
2072
17930
1.22
12.37
4.1
3.9
—
—
—
0
0
4144
38304
1.20
12.26
3.2
3.1
47.99
50.68
u/l
1.04
3827
35551
1280
10526
1.26
12.16
1.4
1.5
2.45
2.49
g/l
0.20
747
6304
1244
10217
1.27
11.92
1.3
1.3
33.09
34.72
iu/ml
0.18
403
3289
550
4034
1.39
11.70
2.4
2.4
22.03
23.23
au/ml
0.09
38
291
1190
9748
1.27
11.63
1.3
1.3
13.17
13.09
u/ml
0.01
407
3769
2355
20738
1.21
11.57
5.5
5.0
3.06
3.23
ug/l
0.10
2113
18629
1415
11918
1.24
10.72
1.3
1.2
2.15
1.92
u/ml
0.14
322
3154
5303
50449
1.22
10.52
17.5
17.2
15.23
15.15
%
0.40
5207
49591
781
6138
1.31
10.52
4.2
4.2
—
—
—
0
0
497
3675
1.38
10.08
1.3
1.3
32.49
56.73
au/ml
2.42
26
210
2725
24528
1.18
10.07
2.0
2.0
98.80
95.36
pmol/l
2.92
1349
12738
3722
34388
1.18
10.01
8.8
9.4
3.94
4.07
e9/l
3.19
3222
29887
1879
16377
1.20
9.98
1.7
1.6
1.26
1.37
mmol/l
9.69
1548
13671
1144
9506
1.24
9.73
3.2
3.0
2.18
2.41
e6/l
0.37
616
5106
1047
8637
1.25
9.48
1.2
1.2
—
—
—
0
0
285
4099
0.68
9.02
5.0
4.9
—
—
—
0
0
332
2336
1.44
8.97
2.5
2.8
—
—
—
0
0
2318
20736
1.18
8.92
4.0
3.7
58.44
99.36
e6/l
4.03
1589
14743
3278
30145
1.17
8.89
6.9
6.7
1.22
1.21
mmol/l
5.19
2799
25673
961
7914
1.25
8.80
1.4
1.3
628.63
520.71
titre
0.70
190
1684
562
4324
1.33
8.80
1.2
1.2
—
—
—
0
0
858
6975
1.26
8.79
1.3
1.3
—
—
—
0
0
2269
20286
1.18
8.75
3.4
3.5
2.36
2.36
mmol/l
0.07
1969
17824
1822
16004
1.19
8.65
3.3
3.1
—
—
—
0
0
267
3839
0.68
8.45
7.2
7.2
24.60
24.62
mmol/l
0.03
247
3656
319
2261
1.43
8.31
1.1
1.1
—
—
—
0
0
248
1683
1.49
8.10
1.0
1.1
—
—
—
0
0
2274
20432
1.17
8.09
3.0
2.9
—
—
—
0
0
2986
27412
1.16
7.95
6.1
6.0
1.22
1.21
mmol/l
6.98
2669
25078
169
1058
1.61
7.93
1.9
1.9
202.85
196.46
pmol/l
0.31
160
1001
240
1629
1.49
7.84
1.2
1.3
82.14
37.68
u/ml
—
10
94
2107
18909
1.16
7.48
2.5
2.4
—
—
—
0
0
1861
16541
1.17
7.48
3.4
3.2
0.34
0.42
e6/l
0.82
1371
12508
1207
10340
1.20
7.44
3.0
2.8
1.34
1.39
e6/l
0.04
677
5895
1754
15539
1.17
7.31
4.0
4.0
90.29
90.26
%
0.02
1727
15176
959
8057
1.22
7.22
1.2
1.3
—
—
—
0
0
4073
38409
1.15
7.02
4.5
4.4
1447.58
1169.52
e6/l
0.14
36
516
374
2804
1.35
7.01
1.2
1.2
—
—
—
0
0
403
3056
1.34
7.01
1.5
1.5
—
—
—
0
0
2824
25985
1.15
6.97
10.0
9.7
0.00
0.00
e9/l
0.36
2282
21126
1996
17920
1.16
6.94
3.5
3.3
51.82
75.50
e6/l
0.93
1486
13698
218
1491
1.48
6.91
1.2
1.3
1.91
2.81
u/ml
1.22
13
143
219
1506
1.47
6.76
1.2
1.3
5.96
6.89
u/ml
0.13
30
237
1855
16651
1.16
6.37
4.5
4.3
21.63
21.85
%
0.25
956
8410
797
6662
1.22
6.29
2.0
2.2
116.76
140.19
ug/g
1.33
621
5259
177
1187
1.50
6.22
1.2
1.3
32.83
44.37
u/ml
0.38
18
121
141
2155
0.65
6.14
4.2
4.0
1.35
1.39
mmol/l
0.15
135
2122
552
4449
1.26
6.08
4.1
3.6
84.17
89.76
ng/l
0.94
474
3833
244
1764
1.40
5.79
1.6
1.8
—
—
—
0
0
1806
16274
1.15
5.79
2.6
2.7
4738.27
4290.54
umol/l
0.18
1561
14233
1448
12855
1.16
5.69
1.7
1.7
1.03
1.25
mg/l
2.81
1090
9920
78
437
1.79
5.63
1.1
1.1
—
—
—
0
0
1525
13637
1.15
5.40
1.5
1.5
21.63
20.59
nmol/l
1.63
1263
11683
675
5652
1.22
5.24
2.4
2.4
42.18
47.79
u/l
0.25
583
4838
89
530
1.69
5.22
1.1
1.1
—
—
—
0
0
3361
31660
1.12
5.10
5.9
6.6
11.30
11.39
umol/l
0.24
3186
30164
172
2434
0.70
5.10
4.7
4.8
—
—
—
0
0
2019
18464
1.13
5.06
2.0
2.2
167.87
211.64
u/l
2.81
1892
17302
438
3517
1.26
5.02
3.5
3.3
4.52
4.45
pmol/l
0.77
393
3121
1610
14535
1.14
4.91
2.5
2.3
—
—
—
0
0
239
1779
1.36
4.81
1.1
1.1
—
—
—
0
0
1057
9283
1.16
4.74
1.9
2.1
29.62
29.83
s
0.56
1029
9025
141
2032
0.69
4.66
12.6
9.7
—
—
—
0
0
404
3245
1.26
4.64
2.6
2.4
—
—
—
0
0
41
200
2.06
4.52
2.1
1.5
—
—
—
0
0
1240
11060
1.15
4.49
3.0
3.1
2.44
2.46
mmol/l
3.08
1080
9689
1953
17935
1.12
4.47
4.4
4.1
7.40
7.40
ph
0.88
328
3405
485
5853
0.82
4.46
8.7
8.3
120.79
121.69
g/l
0.45
468
5695
3032
28544
1.11
4.41
5.1
4.8
0.00
0.00
estimate
0.36
538
5184
139
961
1.46
4.32
1.3
1.2
252.36
287.62
u/ml
0.86
88
599
80
489
1.64
4.32
2.4
2.3
—
—
—
0
0
3062
28864
1.11
4.31
3.7
3.6
0.01
0.00
estimate
0.40
525
5064
213
1588
1.35
4.28
2.3
1.9
10.93
11.52
mg/l
0.46
200
1464
422
3444
1.24
4.24
1.3
1.3
176.85
231.67
u/ml
1.09
391
3173
490
4063
1.22
4.23
1.3
1.2
—
—
—
0
0
4460
42902
1.11
4.19
3.9
3.8
—
—
—
0
0
1294
11632
1.14
4.15
3.0
2.9
543.21
545.28
mosm/kgh2o
0.12
1084
9966
77
472
1.64
4.13
1.2
1.2
—
—
—
0
0
1117
12498
0.87
4.11
4.1
4.0
1.02
1.02
kg/l
1.78
184
1827
215
1616
1.34
4.11
1.5
1.4
10.99
19.42
iu/ml
—
7
38
820
7144
1.17
4.08
1.9
1.6
—
—
—
0
0
5075
49189
1.12
4.07
18.6
18.7
332.39
332.22
g/l
0.67
5051
48883
153
1090
1.41
4.07
1.8
1.9
5.27
5.12
mmol/24h
0.21
136
960
87
553
1.58
4.04
1.2
1.4
—
—
—
0
0
822
7171
1.17
4.02
1.4
1.5
—
—
—
0
0
46
247
1.87
3.91
3.0
2.7
—
—
—
0
0
3662
34954
1.10
3.84
4.7
4.7
6.63
6.68
mmol/l
0.86
3450
32876
604
7032
0.85
3.78
7.6
7.4
0.66
1.11
mmol/l
2.21
493
5618
330
2670
1.25
3.63
3.5
3.5
—
—
—
0
0
97
1422
0.68
3.60
7.4
7.3
105.22
105.30
mmol/l
0.06
83
1277
301
2413
1.26
3.59
2.3
2.4
7.17
7.39
g/l
1.29
267
2184
542
6340
0.84
3.59
8.1
7.8
96.06
95.66
%
0.93
511
6112
97
1421
0.68
3.59
7.4
7.3
11.36
11.23
mmol/l
0.15
83
1276
198
1504
1.33
3.58
3.7
2.8
1.57
1.54
mg/l
0.22
180
1383
3006
28493
1.10
3.55
3.7
3.6
0.00
0.00
estimate
2.79
572
5512
2761
26068
1.10
3.54
4.6
4.9
35.96
35.46
g/l
5.38
2547
24279
300
2410
1.26
3.52
2.3
2.4
3.57
3.66
g/l
0.63
266
2182
290
2323
1.26
3.49
3.8
3.7
24.80
25.00
mmol/l
0.66
269
2128
84
551
1.53
3.45
1.1
1.1
1.53
2.86
u/ml
1.61
41
242
1623
14947
1.11
3.41
3.4
3.3
—
—
—
0
0
612
7053
0.85
3.39
7.6
7.4
5.08
5.11
kpa
0.39
574
6752
612
7052
0.86
3.38
7.6
7.4
13.18
12.38
kpa
2.83
575
6745
47
798
0.59
3.38
4.4
5.1
369.46
359.08
umol/l
0.23
35
689
267
2134
1.26
3.30
1.8
2.0
22.16
21.50
s
0.72
231
1876
250
1984
1.27
3.28
1.3
1.3
35.98
36.22
iu/l
0.03
221
1708
2943
27941
1.09
3.27
2.6
2.6
—
—
—
0
0
88
592
1.49
3.24
1.5
1.4
0.29
0.25
nmol/l
0.28
65
415
77
507
1.52
3.14
1.1
1.1
1.75
2.71
u/ml
0.58
31
190
182
1395
1.31
3.13
1.3
1.2
—
—
—
0
0
32
165
1.94
3.13
5.7
4.5
—
—
—
0
0
1416
15385
0.90
3.12
4.4
4.0
0.00
0.00
estimate
0.09
522
4990
278
2250
1.25
3.10
2.3
2.4
10.28
10.16
g/l
0.21
243
2008
600
5218
1.16
3.09
2.2
2.3
377.75
371.45
nmol/l
0.37
562
4795
432
3657
1.19
3.08
3.5
3.4
7.43
7.42
ph
1.18
49
462
280
2272
1.24
3.06
2.4
2.4
2.87
2.93
g/l
0.41
246
2046
2970
28268
1.09
3.05
15.4
14.5
1.27
1.26
inr
0.15
827
8063
165
1254
1.32
3.03
1.7
1.7
289.46
303.65
mu/l
0.30
155
1155
32
168
1.91
2.98
1.1
1.1
—
—
—
0
0
1843
17198
1.10
2.93
2.9
2.9
1079.96
1226.40
ng/l
1.11
1565
14829
436
3713
1.19
2.92
3.5
3.4
5.08
5.15
kpa
1.34
411
3531
1526
14120
1.10
2.89
2.3
2.2
2.75
2.96
mg/l
2.92
1280
12082
32
173
1.85
2.76
1.0
1.0
—
—
—
0
0
420
3590
1.18
2.72
1.2
1.2
140.14
144.72
iu/ml
0.08
147
1372
105
759
1.39
2.70
2.2
2.1
29.44
24.24
mg/l
0.41
34
185
2414
22870
1.09
2.68
3.3
3.3
5.76
5.80
ph
0.26
185
1598
11
281
0.39
2.67
15.5
12.2
801.91
832.30
nmol/l
0.08
11
265
307
2564
1.21
2.58
1.7
1.6
28.96
13.77
u/ml
—
9
64
219
1767
1.25
2.57
1.4
1.6
1.16
1.19
g/l
0.82
208
1663
110
809
1.37
2.56
1.1
1.1
1.20
1.91
u/ml
0.59
55
400
212
1705
1.25
2.56
1.4
1.6
0.23
0.24
g/l
0.49
202
1604
87
616
1.42
2.54
1.2
1.4
—
—
—
0
0
179
1413
1.27
2.53
1.8
1.7
47.73
4.43
iu/l
0.50
72
485
202
1618
1.26
2.53
1.2
1.2
—
—
—
0
0
88
625
1.41
2.52
1.1
1.1
0.79
1.31
u/ml
0.73
46
296
150
1158
1.30
2.52
1.4
1.3
12.26
11.58
u/l
0.19
119
935
102
747
1.37
2.46
1.2
1.3
—
—
—
0
0
230
1880
1.23
2.42
2.4
2.2
37.99
37.90
g/l
0.08
195
1650
58
384
1.51
2.39
1.2
1.3
176.10
182.56
pmol/l
0.09
58
384
28
154
1.82
2.33
1.1
1.1
—
—
—
0
0
518
4569
1.14
2.26
1.4
1.4
—
—
—
0
0
58
390
1.49
2.24
1.7
1.5
79.55
83.15
umol/l
0.51
58
390
90
659
1.37
2.20
1.2
1.2
—
—
—
0
0
634
5677
1.13
2.20
1.5
1.5
—
—
—
0
0
15
67
2.24
2.17
6.1
12.0
5.11
5.22
mmol/l
0.08
15
67
89
653
1.37
2.16
1.8
1.7
—
—
—
0
0
138
1080
1.28
2.15
1.6
1.4
—
—
—
0
0
441
5010
0.87
2.08
4.0
3.4
—
—
—
0
0
624
5603
1.12
2.08
1.8
1.5
—
—
—
0
0
396
3451
1.16
2.07
1.8
1.9
1.32
1.35
g/l
0.09
357
3134
123
955
1.29
2.05
1.7
1.3
158.14
116.39
u/ml
0.46
19
193
20
103
1.94
2.04
1.0
1.3
—
—
—
0
0
419
3672
1.15
2.04
1.5
1.4
—
—
—
0
0
1620
15255
1.08
2.02
6.9
7.0
—
—
—
0
0
1257
11716
1.09
2.01
3.7
3.7
248.23
513.23
ng/l
2.16
983
9268
102
775
1.32
2.00
1.1
1.1
12.52
14.96
au/ml
—
5
37
507
4508
1.13
1.99
1.4
1.4
—
—
—
0
0
165
1334
1.24
1.98
2.1
2.1
130.67
128.47
g/l
0.50
103
940
41
264
1.56
1.97
26.4
27.1
101.63
112.47
ug/l
0.63
32
220
292
2501
1.17
1.93
1.7
1.5
—
—
—
0
0
1329
12442
1.08
1.92
2.7
2.6
4.17
5.21
e6/l
3.41
1163
11165
303
2607
1.17
1.90
1.7
1.7
—
—
—
0
0
36
227
1.59
1.89
1.1
1.1
—
—
—
0
0
129
1020
1.27
1.89
1.4
1.5
—
—
—
0
0
161
1972
0.81
1.88
5.6
6.2
1.32
1.31
mmol/l
0.06
141
1749
91
689
1.33
1.85
1.1
1.1
0.53
1.21
u/ml
1.42
37
282
72
529
1.36
1.79
5.6
5.2
72.67
98.41
u/ml
0.18
19
161
52
362
1.44
1.76
1.1
1.1
—
—
—
0
0
494
4428
1.12
1.74
2.7
2.8
10.52
10.46
g/l
0.10
452
4044
55
388
1.42
1.74
6.6
6.4
—
—
—
0
0
80
601
1.33
1.73
1.6
1.4
15.57
22.58
iu/ml
—
7
26
11
48
2.29
1.70
1.0
1.0
—
4.30
—
0
5
15
75
2.00
1.69
1.7
1.6
143.20
120.70
ug/l
—
10
62
2369
22738
1.06
1.68
3.7
3.5
33.59
65.70
ng/l
0.94
1654
15872
33
211
1.57
1.67
1.1
1.1
1760.73
1582.99
miu/ml
0.43
33
211
1636
15516
1.07
1.67
1.3
1.3
—
—
—
0
0
134
1083
1.24
1.67
3.4
2.9
—
—
—
0
0
641
5847
1.11
1.66
1.4
1.4
—
—
—
0
0
7
25
2.80
1.65
1.3
1.8
—
—
—
0
0
91
704
1.30
1.62
1.1
1.1
3.88
4.48
u/ml
0.15
38
323
5
14
3.57
1.61
1.2
1.1
854.00
495.32
nmol/l
—
5
14
6
20
3.00
1.58
3.7
1.6
2.90
1.32
mg/l
—
6
13
198
1675
1.19
1.57
2.3
2.5
3.54
3.60
g/l
0.25
192
1592
1985
18986
1.06
1.56
2.7
2.6
62.83
65.37
u/l
0.21
1803
17541
677
6216
1.10
1.55
1.7
1.5
—
—
—
0
0
27
168
1.61
1.54
1.1
1.0
—
—
—
0
0
71
535
1.33
1.54
1.1
1.1
—
—
—
0
0
42
290
1.45
1.52
1.8
1.5
—
—
—
0
0
757
6994
1.09
1.51
2.8
2.8
6.90
8.25
umol/l
1.21
674
6107
214
1832
1.17
1.49
2.8
3.2
—
—
—
0
0
151
1255
1.21
1.47
1.2
1.4
36.37
34.08
e6/l
0.04
111
955
59
437
1.35
1.45
1.7
2.0
3.19
1.74
u/field
0.62
16
176
20
117
1.71
1.44
1.0
1.1
0.56
1.56
u/ml
—
8
53
151
1259
1.20
1.43
1.3
1.4
548.12
1406.92
e6/l
1.57
114
1016
248
2157
1.16
1.43
1.6
1.6
—
—
—
0
0
45
320
1.41
1.41
1.5
1.7
11.10
9.36
umol/l
0.20
37
215
263
2301
1.15
1.40
1.2
1.3
0.18
1.04
u/ml
3.34
16
226
135
1117
1.21
1.39
1.5
1.5
—
—
—
0
0
513
4677
1.10
1.38
3.7
3.9
0.62
0.73
%
0.54
174
1603
347
3099
1.13
1.36
1.2
1.2
—
—
—
0
0
899
8409
1.08
1.36
2.0
2.0
—
—
—
0
0
8
162
0.49
1.35
1.4
1.6
—
—
—
0
0
41
290
1.42
1.34
2.4
2.8
—
—
—
0
0
1197
12638
0.94
1.31
1.6
1.7
25242112.92
35282861.22
pmol/l
0.28
931
10569
1138
10754
1.07
1.30
1.7
1.7
1117.11
1162.62
nmol/l
0.92
825
8149
51
377
1.36
1.30
1.1
1.1
268.38
282.55
mg/l
0.18
42
335
26
170
1.53
1.25
1.4
1.6
0.72
0.56
mmol/l
0.06
26
160
122
1013
1.21
1.25
1.2
1.2
—
—
—
0
0
548
5043
1.09
1.24
2.5
2.7
66.59
66.45
g/l
0.18
489
4598
79
627
1.26
1.22
3.9
3.5
57.58
56.59
%
0.14
68
532
69
539
1.28
1.21
1.2
1.2
—
—
—
0
0
461
4213
1.10
1.21
2.4
3.0
4.55
5.03
e9/l
0.42
360
3399
8
37
2.16
1.21
1.0
1.0
—
—
—
0
0
462
4223
1.10
1.21
2.3
2.4
—
—
—
0
0
14
238
0.59
1.19
1.6
2.2
633.00
3989.07
e6/l
—
7
166
52
392
1.33
1.19
1.2
1.2
41.89
40.53
mg/l
0.09
42
337
558
5151
1.09
1.18
2.6
2.8
141.31
182.99
ng/l
2.49
504
4709
10
50
2.00
1.16
1.4
1.6
—
—
—
0
0
137
1162
1.18
1.14
1.2
1.4
—
—
—
0
0
11
58
1.90
1.12
1.1
1.0
—
—
—
0
0
524
4840
1.09
1.11
4.0
4.1
0.05
0.12
%
3.84
164
1567
42
310
1.36
1.11
1.1
1.1
1.08
1.05
ratio
0.33
14
104
132
1119
1.18
1.11
1.8
1.6
—
—
—
0
0
33
234
1.41
1.10
1.2
1.2
—
—
—
0
0
498
4593
1.09
1.10
3.9
4.1
0.73
0.27
%
0.34
141
1323
170
1477
1.15
1.06
3.8
4.0
—
—
—
0
0
297
2675
1.12
1.06
5.8
4.0
24.28
24.28
mmol/l
0.01
290
2629
10
52
1.92
1.06
1.1
1.7
—
—
—
0
0
38
279
1.36
1.05
1.0
1.0
—
—
—
0
0
176
1535
1.15
1.05
1.6
1.6
9933.12
14286.07
e6/l
0.71
115
1085
85
697
1.22
1.03
1.4
2.5
—
—
—
0
0
13
75
1.73
1.02
1.8
1.7
—
—
—
0
0
33
238
1.39
1.02
1.1
6.2
69.00
60.88
mg/l
0.33
22
177
76
618
1.23
1.00
3.2
3.3
—
—
—
0
0
25
172
1.46
0.99
3.3
2.3
0.45
0.92
ug/l
3.07
25
162
160
1395
1.15
0.97
1.4
1.3
—
—
—
0
0
9
50
1.80
0.96
1.3
1.2
—
—
—
0
0
10
54
1.85
0.96
2.8
2.1
—
—
—
0
0
192
1698
1.13
0.96
1.4
1.4
—
—
—
0
0
12
198
0.61
0.95
1.6
1.9
—
—
—
0
0
294
2670
1.11
0.93
1.7
1.7
1.48
1.59
g/l
1.20
248
2276
112
954
1.18
0.93
2.5
2.4
—
—
—
0
0
181
1599
1.14
0.92
1.3
1.3
—
—
—
0
0
21
142
1.48
0.92
1.8
1.3
134.78
75.10
mu/l
0.28
14
111
13
78
1.67
0.91
1.5
1.7
2.66
2.81
mmol/l
0.10
13
67
160
1404
1.14
0.91
1.2
1.2
—
—
—
0
0
88
736
1.20
0.90
1.2
1.4
—
—
—
0
0
820
7773
1.06
0.90
6.6
5.5
1.02
1.03
mmol/l
0.02
757
7237
110
1284
0.85
0.90
2.8
2.8
32.79
34.93
umol/l
0.54
103
1162
6
29
2.07
0.89
1.7
1.1
—
—
—
0
0
71
861
0.82
0.89
2.3
2.2
—
—
—
0
0
7
127
0.55
0.88
1.1
1.4
—
85.96
—
0
23
92
776
1.19
0.87
1.5
1.6
58.26
58.90
%
0.05
58
469
46
360
1.28
0.86
1.4
1.5
4.95
6.50
u/l
1.89
41
303
49
387
1.27
0.86
1.3
1.3
0.89
1.32
u/ml
0.24
32
218
60
737
0.81
0.86
1.2
1.2
—
—
—
0
0
104
888
1.17
0.86
2.8
2.7
—
—
—
0
0
223
2474
0.90
0.86
4.8
5.4
0.91
0.89
%
0.18
207
2318
62
504
1.23
0.85
1.0
1.0
—
—
—
0
0
39
299
1.31
0.85
1.4
1.5
1.22
4.02
%
—
9
66
96
1126
0.85
0.84
4.1
1.5
0.93
0.84
nmol/l
0.75
78
945
27
197
1.37
0.81
1.0
1.1
—
—
—
0
0
14
213
0.66
0.81
1.9
2.0
—
—
—
0
0
8
47
1.70
0.80
1.4
1.2
—
—
—
0
0
8
47
1.70
0.80
1.9
1.9
2.75
1.50
mg/l
—
8
40
5
97
0.52
0.78
1.6
1.2
0.24
1.95
mmol/l
—
5
69
161
1433
1.13
0.77
1.1
1.1
5.75
7.50
u/ml
0.19
20
158
25
338
0.74
0.77
1.4
1.3
—
—
—
0
0
720
6839
1.06
0.76
1.8
1.7
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
111
965
1.15
0.76
1.1
1.1
—
—
—
0
0
2004
19507
1.04
0.75
3.2
3.4
31.10
35.19
u/l
2.69
1903
18472
143
1267
1.13
0.74
1.2
1.2
3.73
3.75
mmol/l
0.09
138
1185
5
24
2.08
0.74
1.0
1.0
—
—
—
0
0
86
735
1.17
0.73
1.1
1.1
—
—
—
0
0
10
60
1.67
0.72
1.3
1.1
6.74
7.05
mmol/l
—
5
29
86
737
1.17
0.71
1.1
1.1
—
—
—
0
0
13
84
1.55
0.71
2.0
2.4
14.88
69.27
mg/l
—
6
11
49
398
1.23
0.71
1.2
1.2
—
—
—
0
0
137
1215
1.13
0.71
4.7
3.1
—
—
—
0
0
5
26
1.92
0.70
4.0
2.9
—
—
—
0
0
32
247
1.30
0.70
1.2
1.1
77.20
437.90
ng/l
—
6
61
324
3009
1.08
0.68
3.3
3.4
—
—
—
0
0
126
1116
1.13
0.68
2.5
3.8
62.08
30.04
u/ml
0.52
119
1089
426
3999
1.07
0.68
1.3
1.3
—
—
—
0
0
93
807
1.15
0.67
5.9
6.5
10.80
11.80
mg/l
1.61
87
741
55
456
1.21
0.67
1.1
1.0
284.92
289.02
mg/l
0.19
50
406
17
119
1.43
0.66
2.4
3.5
125.80
165.42
ng/l
—
5
43
5
28
1.79
0.66
1.4
1.7
—
—
—
0
0
318
3416
0.93
0.66
10.3
10.0
—
—
—
0
0
50
412
1.22
0.65
1.9
2.5
—
—
—
0
0
39
313
1.25
0.64
1.1
1.1
—
—
—
0
0
93
811
1.15
0.64
1.1
1.1
1.53
1.52
g/l
0.12
85
727
79
914
0.86
0.64
1.4
1.3
0.44
0.23
nmol/l
—
5
64
80
690
1.16
0.64
2.5
2.3
—
—
—
0
0
10
153
0.65
0.62
2.3
2.2
—
—
—
0
0
12
79
1.52
0.62
1.0
1.1
—
—
—
0
0
150
1352
1.11
0.62
1.1
1.1
—
—
—
0
0
10
63
1.59
0.61
1.1
1.1
—
—
—
0
0
31
244
1.27
0.61
1.5
1.7
2.48
5.08
ug/l
1.01
26
167
0
20
0.00
0.60
0.0
1.3
—
—
—
0
0
23
174
1.32
0.59
1.1
1.1
—
—
—
0
0
159
1442
1.11
0.59
1.2
1.3
470.21
537.55
mg/l
2.13
153
1362
46
381
1.21
0.59
1.2
1.1
—
—
—
0
0
22
166
1.33
0.58
1.1
1.1
—
—
—
0
0
22
166
1.33
0.58
1.1
1.1
—
—
—
0
0
22
166
1.33
0.58
1.1
1.1
—
—
—
0
0
49
409
1.20
0.58
1.4
1.9
6.58
6.81
mmol/l
0.29
35
282
232
2507
0.92
0.58
4.6
5.3
1.64
1.65
%
0.07
214
2343
14
196
0.71
0.57
3.1
3.6
35.29
54.18
%
2.30
14
189
37
302
1.23
0.55
1.4
1.3
—
—
—
0
0
1807
17656
1.03
0.55
3.1
3.0
—
—
—
0
0
65
751
0.86
0.54
1.1
1.2
6.63
7.57
mmol/l
2.44
47
658
74
645
1.15
0.54
1.1
1.1
—
—
—
0
0
9
60
1.50
0.54
1.0
1.0
—
—
—
0
0
1939
18973
1.03
0.54
3.3
3.1
7.59
7.57
mmol/l
0.04
1632
15909
57
487
1.17
0.54
1.3
1.1
384.30
359.22
nmol/l
0.42
47
412
412
3902
1.06
0.53
2.7
2.9
—
—
—
0
0
20
151
1.33
0.53
1.6
1.2
181.92
317.05
pmol/l
2.77
13
111
215
1991
1.08
0.53
3.4
3.0
0.29
0.28
g/l
0.08
93
829
81
712
1.14
0.53
1.1
1.1
6.01
3.21
u/ml
0.38
42
303
107
958
1.12
0.52
2.3
1.6
0.92
0.81
g/l
0.39
82
732
13
181
0.72
0.52
1.3
1.6
9.92
8.96
ug/l
0.58
13
181
344
3245
1.06
0.51
9.1
9.6
24.27
24.40
mmol/l
0.36
332
3164
66
573
1.15
0.51
1.4
1.5
28.02
31.32
%
0.31
39
337
94
837
1.12
0.51
1.2
1.2
3.54
4.41
u/ml
0.29
41
350
19
144
1.32
0.50
1.2
1.5
—
—
—
0
0
48
407
1.18
0.50
1.2
1.1
—
—
—
0
0
37
306
1.21
0.50
3.2
3.4
—
—
—
0
0
680
6539
1.04
0.50
2.3
2.5
1.71
1.79
%
1.08
582
5810
53
454
1.17
0.49
1.1
1.0
0.11
0.45
u/ml
0.74
14
138
824
7959
1.04
0.49
2.9
2.5
25.18
22.84
%
4.14
711
6798
197
1827
1.08
0.49
1.5
1.4
278.70
274.41
ug/g
0.12
115
1068
53
456
1.16
0.47
1.2
1.2
—
—
—
0
0
1032
10024
1.03
0.46
3.0
3.4
0.82
0.81
mmol/l
1.21
962
9434
259
2756
0.94
0.46
3.4
3.4
25.00
25.25
mmol/l
0.63
253
2671
73
824
0.88
0.46
1.3
1.3
—
—
—
0
0
23
182
1.26
0.46
1.5
1.2
38.41
39.06
g/l
—
10
92
563
5863
0.96
0.46
2.2
2.2
0.21
0.21
g/l
0.33
536
5474
5
81
0.62
0.45
1.8
1.2
44.80
431.41
u/l
—
5
60
8
117
0.68
0.45
1.1
1.4
—
—
—
0
0
8
118
0.68
0.45
1.4
1.6
—
—
—
0
0
17
129
1.32
0.45
1.8
2.0
800.83
311.90
e6/l
0.38
12
63
13
175
0.74
0.44
1.8
1.4
—
—
—
0
0
534
5126
1.05
0.44
4.0
4.1
0.64
0.97
%
3.41
174
1843
113
1028
1.10
0.44
3.5
3.4
1.22
1.62
%
0.67
101
915
499
5203
0.96
0.44
2.2
2.3
7.17
7.61
ug/l
0.20
433
4575
49
566
0.86
0.44
3.9
2.9
48.64
45.82
mg/l
0.03
30
404
69
611
1.13
0.43
1.4
1.5
—
—
—
0
0
449
4296
1.05
0.43
3.7
3.0
4.64
4.59
kpa
0.17
437
4160
292
2764
1.06
0.42
1.9
1.9
—
—
—
0
0
942
9155
1.03
0.42
2.8
2.4
14.04
13.11
umol/l
3.36
869
8555
1862
18281
1.03
0.41
3.4
3.1
437.80
421.21
mg/l
0.05
1140
11449
15
114
1.32
0.40
1.1
1.2
—
—
—
0
0
72
644
1.12
0.40
1.4
1.6
—
—
—
0
0
331
3152
1.05
0.39
2.9
3.8
45.15
54.58
u/ml
0.30
316
3030
493
4740
1.04
0.39
4.3
4.0
—
—
—
0
0
40
343
1.17
0.39
1.1
1.1
13.56
10.16
nmol/l
—
5
73
50
437
1.15
0.39
2.2
2.0
1.77
2.46
ug/l
1.27
42
362
221
2081
1.06
0.39
2.0
2.3
272.11
624.93
ug/l
2.06
213
1963
54
475
1.14
0.39
1.1
1.2
175.00
156.55
titre
—
6
87
513
4946
1.04
0.37
3.6
3.9
1.23
1.23
mmol/l
0.73
429
4388
9
69
1.30
0.37
4.7
8.4
—
—
—
0
0
70
629
1.11
0.37
2.8
2.4
—
—
—
0
0
54
609
0.89
0.36
3.6
4.8
6.94
7.34
mmol/l
0.48
44
513
69
620
1.11
0.36
1.6
1.2
—
—
—
0
0
12
90
1.33
0.35
1.2
1.3
67.11
45.25
mg/l
0.95
12
77
74
669
1.11
0.35
4.4
4.1
—
—
—
0
0
17
135
1.26
0.35
1.1
1.1
—
520.00
—
0
8
6
43
1.40
0.35
1.5
1.4
—
—
—
0
0
9
125
0.72
0.35
3.7
2.8
13067.44
1728.49
u/l
—
9
117
10
73
1.37
0.34
1.0
1.1
—
—
—
0
0
37
320
1.16
0.34
1.0
1.1
6.84
12.08
iu/ml
—
10
84
44
386
1.14
0.34
1.3
1.3
1.57
1.58
g/l
0.08
44
386
208
1967
1.06
0.34
3.8
3.5
37.77
47.02
mg/l
0.58
172
1595
25
297
0.84
0.33
2.0
2.3
1889.11
1886.31
ml
0.00
19
261
208
1968
1.06
0.33
3.8
3.5
39.28
82.15
mg/l
0.85
171
1595
14
109
1.28
0.33
1.4
1.4
—
—
—
0
0
1953
19240
1.02
0.33
3.9
3.7
7.22
8.07
mg/mmol
0.37
1183
11937
27
318
0.85
0.33
2.9
1.8
—
—
—
0
0
43
488
0.88
0.33
1.4
2.4
—
—
—
0
0
71
644
1.10
0.33
1.6
1.4
103465.69
56950.15
e6/l
0.54
39
375
7
53
1.32
0.30
1.1
2.1
1.00
0.62
u/field
—
7
53
7
55
1.27
0.30
1.1
1.1
—
—
—
0
0
50
448
1.12
0.29
2.2
1.9
3.05
3.46
ug/l
0.26
44
403
68
620
1.10
0.29
1.7
1.4
0.33
0.41
g/l
1.07
46
441
68
620
1.10
0.29
1.7
1.4
3.03
2.94
g/l
0.16
48
442
19
228
0.83
0.29
2.1
2.0
52.36
57.85
ug/l
0.22
19
222
38
335
1.14
0.29
1.0
1.1
—
—
—
0
0
68
621
1.10
0.29
1.8
1.4
6.36
6.88
g/l
0.77
48
442
41
461
0.89
0.28
2.1
1.7
—
—
—
0
0
133
1250
1.07
0.28
2.7
2.8
8.26
8.03
kpa
1.04
127
1228
77
836
0.92
0.28
1.8
2.0
21.29
24.40
ug/l
0.35
77
824
91
844
1.08
0.28
1.3
1.9
—
—
—
0
0
865
8466
1.02
0.27
2.8
2.4
2.30
2.32
g/l
0.51
791
7844
14
172
0.81
0.27
1.4
1.5
—
—
—
0
0
136
1283
1.06
0.26
3.6
3.7
—
—
—
0
0
201
1919
1.05
0.26
3.8
3.4
2.26
1.92
ratio
0.12
12
156
77
712
1.08
0.26
1.6
1.5
1813.40
2090.76
e6/l
0.28
53
515
10
77
1.30
0.26
3.5
4.5
55.30
47.00
ug/min
—
10
60
29
331
0.88
0.26
1.9
2.9
7.42
7.42
ph
0.01
12
117
748
7645
0.98
0.25
7.2
7.2
104.63
104.48
mmol/l
0.43
748
7640
9
73
1.23
0.25
1.8
1.4
—
—
—
0
0
9
73
1.23
0.25
1.1
1.2
—
—
—
0
0
9
73
1.23
0.25
1.1
1.2
—
—
—
0
0
9
73
1.23
0.25
1.1
1.2
—
—
—
0
0
60
654
0.92
0.25
3.9
2.4
1.13
1.28
g/24h
0.18
23
312
12
96
1.25
0.24
1.5
1.4
—
—
—
0
0
704
6889
1.02
0.24
3.8
4.2
19.87
23.28
ug/l
0.16
551
5651
116
1094
1.06
0.24
1.5
1.5
—
—
—
0
0
146
1536
0.95
0.23
3.7
4.2
7.43
7.42
ph
2.14
137
1399
14
115
1.22
0.23
1.6
1.6
91.36
138.39
ng/l
1.03
14
115
80
748
1.07
0.22
1.7
1.9
90.69
89.62
%
1.33
80
738
14
116
1.21
0.22
1.1
1.1
—
—
—
0
0
102
962
1.06
0.22
1.5
1.4
—
—
—
0
0
132
1255
1.05
0.21
2.6
2.5
16.25
16.12
%
0.14
71
657
0
11
0.00
0.21
0.0
1.1
—
0.02
—
0
6
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
74
792
0.93
0.21
1.3
1.3
—
—
nmol/l
—
0
0
0
12
0.00
0.21
0.0
1.2
—
1835.83
—
0
12
21
241
0.87
0.21
1.4
2.0
51.50
138.16
umol/l
2.10
12
120
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
56
605
0.93
0.20
1.3
1.3
286.84
278.11
mosm/kgh2o
1.67
38
462
91
858
1.06
0.20
2.0
1.4
70.44
60.07
mu/l
0.20
82
768
33
297
1.11
0.20
1.5
1.7
2.35
2.69
u/field
0.09
20
206
16
136
1.18
0.20
5.3
7.1
—
—
—
0
0
12
99
1.21
0.19
6.1
7.1
—
—
—
0
0
15
127
1.18
0.19
2.1
2.0
—
—
—
0
0
6
51
1.18
0.19
1.3
1.1
—
—
—
0
0
30
270
1.11
0.18
6.1
10.4
—
—
—
0
0
317
3084
1.03
0.18
2.8
2.7
0.16
0.30
e6/l
2.71
302
3006
50
463
1.08
0.18
1.0
1.0
376.97
314.56
ng/l
0.86
39
319
13
153
0.85
0.18
1.2
1.2
—
—
—
0
0
50
464
1.08
0.17
1.0
1.0
683.19
729.61
ng/l
0.33
37
309
99
942
1.05
0.17
1.2
1.3
—
—
—
0
0
91
958
0.95
0.17
1.5
1.4
—
—
—
0
0
1591
16068
0.99
0.17
4.4
4.3
—
—
—
0
0
651
6402
1.02
0.16
1.5
1.5
—
—
—
0
0
28
254
1.10
0.16
1.3
1.3
161.64
162.94
mmol/24h
0.03
28
254
11
130
0.85
0.16
1.5
1.4
—
—
—
0
0
21
235
0.89
0.16
3.2
2.5
—
—
—
0
0
1394
13803
1.01
0.15
3.6
3.6
—
—
—
0
0
16
182
0.88
0.15
1.1
1.1
—
—
—
0
0
38
352
1.08
0.14
4.2
3.8
—
—
—
0
0
44
471
0.93
0.14
3.2
2.2
10.80
11.21
%
0.33
44
471
534
5253
1.02
0.14
4.9
3.7
1.92
1.98
mmol/l
0.16
451
4483
506
4976
1.02
0.14
2.4
2.6
69.57
70.07
e9/l
0.10
367
3743
31
285
1.09
0.14
1.3
1.4
—
—
—
0
0
23
208
1.11
0.14
1.1
1.2
—
—
—
0
0
502
4939
1.02
0.13
9.6
8.5
—
—
—
0
0
143
1385
1.03
0.13
3.1
3.5
61.95
667.66
u/ml
2.45
127
1262
9
107
0.84
0.13
5.9
3.0
—
—
—
0
0
9
110
0.82
0.13
3.4
2.8
14.64
14.82
ml/dl
—
9
104
57
601
0.95
0.12
1.4
1.4
186172.84
99539.89
e6/l
0.37
43
405
12
137
0.88
0.12
1.5
2.3
5.66
8.04
mmol/l
—
7
77
17
189
0.90
0.12
1.6
1.3
4.28
3.32
mmol/l
0.73
17
168
102
984
1.04
0.11
1.2
1.3
56.19
37.15
u/l
0.45
89
858
78
813
0.96
0.11
1.6
1.3
265.31
344.25
pmol/l
1.22
70
695
50
474
1.06
0.11
1.6
1.3
—
—
—
0
0
234
2389
0.98
0.11
3.2
3.6
441.18
1525.11
u/ml
1.25
198
2059
243
2479
0.98
0.10
1.8
2.0
1.45
1.95
ug/l
0.41
202
2211
53
556
0.95
0.10
1.6
1.5
—
—
—
0
0
65
623
1.04
0.10
1.8
1.4
—
—
—
0
0
94
972
0.97
0.10
1.3
1.4
—
—
—
0
0
5
44
1.14
0.10
1.4
1.4
—
—
—
0
0
35
330
1.06
0.09
2.4
2.7
45.50
38.26
%
1.35
22
196
19
174
1.09
0.09
1.4
1.2
463.74
282.44
ug/l
—
8
91
15
165
0.91
0.08
1.1
1.1
—
—
—
0
0
43
451
0.95
0.08
2.0
2.2
792.78
641.53
ml
0.75
27
323
31
292
1.06
0.08
1.3
1.3
—
—
—
0
0
15
136
1.10
0.08
1.5
1.9
—
—
—
0
0
95
923
1.03
0.08
1.1
1.1
—
—
—
0
0
533
5275
1.01
0.08
4.8
3.7
5.74
5.84
kpa
1.69
519
5126
7
67
1.04
0.08
1.0
1.3
—
—
—
0
0
113
1103
1.02
0.07
1.3
1.8
—
—
—
0
0
6
75
0.80
0.07
1.0
1.2
—
—
—
0
0
37
388
0.95
0.07
1.1
1.1
—
—
—
0
0
27
286
0.94
0.07
1.9
2.1
—
—
—
0
0
130
1273
1.02
0.07
1.3
1.3
239.66
214.08
miu/ml
0.31
58
547
21
196
1.07
0.07
1.1
1.5
74.81
287.13
nmol/24h
1.38
21
196
8
93
0.86
0.06
1.7
1.7
17.63
46.53
pmol/l
—
8
74
134
1365
0.98
0.06
2.1
2.1
179.92
98.12
ug/min
0.65
73
822
34
325
1.05
0.06
1.2
1.3
—
—
—
0
0
44
424
1.04
0.06
1.5
1.4
12.02
11.95
u/l
0.03
44
410
18
168
1.07
0.06
1.2
1.3
39.83
34.30
%
0.38
12
107
76
742
1.02
0.05
1.8
2.2
32.49
32.93
pg
0.38
76
737
105
1032
1.02
0.04
1.3
1.3
55.62
63.64
mmol/l
1.85
89
816
14
150
0.93
0.04
1.7
1.3
13.79
24.89
%
1.76
14
129
165
1630
1.01
0.04
2.6
2.6
—
—
—
0
0
108
1064
1.02
0.04
2.7
2.7
—
—
—
0
0
355
3527
1.01
0.03
3.8
3.3
128.68
129.31
g/l
0.21
348
3434
14
132
1.06
0.02
1.1
1.1
—
—
—
0
0
67
659
1.02
0.02
2.2
2.2
—
—
—
0
0
28
289
0.97
0.02
1.6
2.0
—
—
—
0
0
49
480
1.02
0.02
1.9
2.2
42.64
38.52
%
1.07
49
474
132
1308
1.01
0.02
3.7
4.3
2.38
2.68
mmol/l
0.63
105
909
112
1109
1.01
0.02
1.3
1.8
—
—
—
0
0
166
1649
1.01
0.01
1.3
1.2
1573.33
860.54
titre
—
6
56
130
1310
0.99
0.01
1.7
1.7
—
—
—
0
0
526
5247
1.00
0.01
7.4
7.2
1.28
1.33
mmol/l
0.63
512
5116
28
287
0.98
0.01
1.9
2.1
8.86
222.50
ug/min
—
7
60
81
817
0.99
0.01
2.0
1.9
7033.63
2565.73
u/l
0.29
25
317
535
5359
1.00
0.01
8.3
7.0
9.50
9.58
mmol/l
0.11
507
5109
107
1077
0.99
0.00
1.3
1.8
—
—
—
0
0
111
1117
0.99
0.00
3.2
3.0
0.77
0.81
nmol/l
0.60
87
844
14
134
1.04
0.00
1.4
1.9
—
—
—
0
0
20
194
1.03
0.00
1.3
1.1
—
—
—
0
0
19
196
0.97
0.00
1.2
1.2
—
—
—
0
0
30
294
1.02
0.00
1.2
1.4
—
—
—
0
0
32
314
1.02
0.00
1.7
2.1
511.95
494.58
min
0.59
22
250
33
336
0.98
0.00
1.8
1.6
—
—
—
0
0
11
113
0.97
0.00
6.5
7.0
—
—
—
0
0
30
296
1.01
0.00
1.2
1.4
—
—
—
0
0
30
304
0.99
0.00
1.3
1.4
—
—
—
0
0
67
674
0.99
0.00
1.6
1.4
42.95
33.57
u/l
1.02
54
540
81
814
1.00
0.00
1.5
1.5
36.48
33.19
g/l
1.93
75
739
102
1016
1.00
0.00
1.3
1.9
—
—
—
0
0
14
135
1.04
0.00
1.1
1.1
—
—
—
0
0
126
1264
1.00
0.00
2.8
3.4
27.12
27.72
mg/l
0.05
71
767
19
195
0.97
0.00
2.1
2.0
23.95
29.75
%
1.13
19
181
25
255
0.98
0.00
1.8
2.0
—
—
—
0
0
30
295
1.02
0.00
1.7
1.3
1.15
1.27
nmol/l
0.23
22
232
164
1645
1.00
0.00
1.3
1.2
329.00
184.69
titre
—
10
147
19
192
0.99
0.00
1.6
1.7
—
—
—
0
0
76
758
1.00
0.00
1.2
1.2
—
—
—
0
0
19
189
1.01
0.00
2.1
1.9
—
—
—
0
0
75
751
1.00
0.00
1.5
1.5
—
—
—
0
0
150
1499
1.00
0.00
3.7
3.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.52
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
97
0.93
-0.00
2.0
1.6
—
—
—
0
0
84
840
1.00
-0.00
1.1
1.1
54.46
12779.90
iu/ml
0.54
25
186
5
58
0.86
-0.00
1.2
1.3
298.24
165.65
mmol/l
—
5
52
110
1100
1.00
-0.00
1.3
1.8
—
—
—
0
0
5
57
0.88
-0.00
1.2
1.1
0.02
0.04
u/ml
—
5
57
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
8
83
0.96
-0.00
1.5
2.0
21.56
18.37
umol/l
—
8
83
6
59
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
83
0.96
-0.00
1.3
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_RETINALBREAK and mortality.

Females

Parameter HR [95% CI] p-value
H7_RETINALBREAK 0.725 [0.65, 0.81] < 0.001
Birth year 0.996 [0.99, 1.0] 0.329

During the follow-up period (1.1.1998 — 31.12.2019), 1190 out of 17611 females with H7_RETINALBREAK died.

Males

Parameter HR [95% CI] p-value
H7_RETINALBREAK 0.638 [0.57, 0.71] < 0.001
Birth year 0.988 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 1476 out of 14412 males with H7_RETINALBREAK died.

Mortality risk

Mortality risk for people of age

years, who have H7_RETINALBREAK.

N-year risk Females Males
1 0.062% 0.134%
5 0.415% 0.759%
10 1.058% 1.968%
15 2.039% 3.615%
20 3.557% 6.424%

Relationships between endpoints

Index endpoint: H7_RETINALBREAK – Retinal breaks without detachment

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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