dilated cardiomyopathy: Cardiomyopathy which is characterized by dilation and contractile dysfunction of the left and right ventricles. It may be idiopathic, or it may result from a myocardial infarction, myocardial infection, or alcohol abuse. It is a cause of congestive heart failure.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditions
|
432914 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2159 |
4. Check minimum number of eventsNone |
2159 |
5. Include endpointsNone |
2159 |
6. Filter based on genotype QC (FinnGen only) |
2159 |
Control definitions (FinnGen only)
- Control conditions
- not I9_IHD
and not I9_HYPERTROCARDMYOP
Extra metadata
- First used in FinnGen datafreeze
- DF3
Nonischemic cardiomyopathy
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16110 | 4481 | 11483 |
| Only index persons | 13468 | 3839 | 9629 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.13 | 0.32 |
| Only index persons | 0.30 | 0.14 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 59.56 | 62.32 | 58.44 |
| Only index persons | 59.28 | 61.85 | 58.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2159 | 619 | 1540 |
| Unadjusted period prevalence (%) | 0.54 | 0.21 | 0.68 |
| Median age at first event (years) | 59.03 | 58.65 | 59.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 1962
- Matched controls
- 19621
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
12.9
323.0
977
1397
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
25.7
323.0
489
250
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
31.2
323.0
1050
698
201
Kela drug reimbursment
Chronic cardiac insufficiency
175.3
323.0
1050
128
I50.0
ICD-10 Finland
Congestive heart failure
23.8
323.0
508
284
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
223.6
323.0
513
31
C03CA01
ATC
furosemide; systemic
15.6
323.0
1368
2526
I50.9
ICD-10 Finland
Heart failure, unspecified
31.7
323.0
1096
752
C07AB07
ATC
bisoprolol; oral
13.3
323.0
1624
5193
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
22.3
323.0
606
385
AN1
HP
Coronary angiography
30.3
323.0
508
223
I50.1
ICD-10 Finland
Left ventricular failure
75.6
323.0
626
121
I42.0
ICD-10 Finland
Dilated cardiomyopathy
4503599627370496.0
323.0
1915
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
8.8
323.0
978
1998
C03DA01
ATC
spironolactone; oral
29.0
323.0
1055
757
C09AA05
ATC
ramipril; oral
10.2
323.0
1157
2419
B01AA03
ATC
warfarin; systemic
6.9
276.1
845
1929
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
2808.7
272.2
257
*
C01AA05
ATC
digoxin; systemic
13.7
270.2
499
477
207
Kela drug reimbursment
Chronic arrhythmias
7.6
247.3
670
1252
C09DX04
ATC
valsartan and sacubitril; oral
2477.4
243.8
231
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.8
237.2
862
2352
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
21.2
236.1
360
206
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
2046.6
205.8
196
*
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
57.0
195.9
232
46
C01BD01
ATC
amiodarone; systemic
27.5
193.3
270
113
XF404
NOMESCO Finland
Ambulatory ECG
7.0
164.1
449
795
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.7
159.6
1180
5715
I44.7
ICD-10 Finland
Left bundle-branch block, unspecified
34.0
155.6
205
67
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
7.0
148.1
404
704
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
751.2
143.9
140
*
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.8
136.2
528
1393
I47.2
ICD-10 Finland
Ventricular tachycardia
26.8
129.2
181
74
TFP20
NOMESCO Finland
Cardiodefibrillation
6.2
119.2
353
672
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
4.8
118.9
454
1160
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
96.9
115.6
127
14
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.4
113.6
477
1334
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
24.8
109.0
156
68
GD1LA
NOMESCO Finland
GD
24.5
107.2
154
68
XF400
NOMESCO Finland
ECG with 12 standard connections
3.9
105.9
508
1595
FPE37
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
1073.7
105.3
102
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
134.4
96.0
102
8
I50
ICD-10 Finland
Heart failure
15.6
94.6
159
110
K77
ICPC
Heart failure
25.1
94.2
134
57
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
117.0
92.9
100
9
81
HP
Angiography of the heart and coronary arteries
19.8
92.5
142
77
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
312.7
88.5
89
*
1CX08
NOMESCO Finland
NA
186.3
85.9
89
5
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
17.0
83.2
135
85
R06.0
ICD-10 Finland
Dyspnoea
3.0
83.0
585
2404
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
6.1
82.9
243
446
I42.8
ICD-10 Finland
Other cardiomyopathies
67.3
78.2
90
14
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
24.5
76.2
109
47
WX892
NOMESCO Finland
Monitored bed care
4.9
73.2
260
593
K78
ICPC
Atrial fibrillation/flutter
4.7
72.9
270
644
K84
ICPC
Heart disease other
14.3
68.7
119
88
B01AF02
ATC
apixaban; oral
3.8
62.1
291
859
I42
ICD-10 Finland
Cardiomyopathy
317.2
60.7
61
*
AP1
HP
Catheterization of the left side of the heart
36.6
57.6
74
21
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
25.6
56.3
79
32
C07AG02
ATC
carvedilol; oral
4.6
54.5
204
486
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
34.5
53.9
70
21
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
11.6
53.8
102
92
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
6.3
53.6
150
256
I51.1
ICD-10 Finland
Rupture of chordae tendineae, not elsewhere classified
+∞
52.3
50
*
TFJ02
NOMESCO Finland
Muscle biopsy of heart
184.9
52.2
54
*
M04AA01
ATC
allopurinol; systemic
2.9
52.1
362
1416
ZX120
NOMESCO Finland
Intravenous
3.4
51.7
275
892
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
35.9
51.3
66
19
FPJ24
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
261.9
50.3
51
*
A10BK01
ATC
dapagliflozin; oral
5.0
50.1
169
360
250
Kela drug reimbursment
NA
256.4
49.3
50
*
XF640
NOMESCO Finland
NA
6.9
47.6
123
188
TFP34
NOMESCO Finland
Electrophysiological investigation
6.7
47.4
126
200
XF402
NOMESCO Finland
ECG with work load test
3.4
47.3
249
798
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
47.2
467
2231
AP4
HP
Myocardial biopsy
128.2
47.0
50
*
Z94.1
ICD-10 Finland
Heart transplant status
74.9
45.2
51
7
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
44.9
267
934
ASB
HP
Insertion of a biventricular physiological pacemaker DDD (R)
230.1
44.1
45
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
42.6
378
1691
I49.3
ICD-10 Finland
Ventricular premature depolarization
3.8
42.2
190
535
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
7.1
41.9
106
157
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
13.0
41.4
74
59
R4110
NOMESCO Finland
Physiotherapy
2.1
41.2
569
3152
WX872
NOMESCO Finland
Intensive care
4.8
41.0
142
311
I48.2
ICD-10 Finland
Chronic atrial fibrillation
6.8
40.7
106
164
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
8.1
39.5
91
117
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
13.5
38.8
68
52
C07AA07
ATC
sotalol; systemic
5.1
38.1
126
262
4254A
ICD-9 Finland
Cardiomyopathy, Other primary cardiomyopathies
136.0
37.8
40
*
C07AB02
ATC
metoprolol; systemic
2.4
37.8
359
1657
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.4
37.3
193
607
I44.2
ICD-10 Finland
Atrioventricular block, complete
6.9
37.3
96
146
R02
ICPC
Shortness of breath/dyspnoea
2.8
36.6
257
998
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
41.8
36.3
45
11
B01AB05
ATC
enoxaparin; parenteral
2.0
36.0
618
3697
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.9
36.0
158
434
XF409
NOMESCO Finland
Other special ECG
22.2
35.8
52
24
M10.9
ICD-10 Finland
Gout, unspecified
3.3
35.7
197
650
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
35.4
498
2750
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
+∞
34.5
33
*
FXL00
NOMESCO Finland
Insertion and use of extra-, para- or intracorporeal VAD
342.8
34.0
34
*
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
32.8
467
2578
AS8
HP
Physiological arrhythmia pacemaker insertionDDD (R) S
+∞
32.4
31
*
XFE00
NOMESCO Finland
Epicardial ultrasonography
7.0
30.9
78
116
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
162.5
30.8
32
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.2
29.9
169
566
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
3.7
29.9
135
380
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
5.5
29.8
90
169
FPE40
NOMESCO Finland
Replacement of transvenous cardiac pacemaker electrode
24.6
29.2
41
17
127
Kela drug reimbursment
Transplant complication
6.6
29.0
76
119
C09AA02
ATC
enalapril; systemic
2.1
29.0
406
2213
H02AB06
ATC
prednisolone; systemic
1.7
28.9
877
6241
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.3
28.3
289
1368
A12BA01
ATC
potassium chloride; oral
4.4
28.2
106
252
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.3
28.0
149
478
FPE36
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with ventricular electrodes
285.3
27.8
28
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.1
27.1
154
517
FPE25
NOMESCO Finland
Implantation of biventricular cardiac pacemaker, atrial and ventricular electrodes, CRT-P (DDDR)
62.9
27.0
31
5
I48.1
ICD-10 Finland
Persistent atrial fibrillation
5.2
27.0
85
168
AS7
HP
Arrhythmia pacemaker insertion VVI (R) S
274.6
26.8
27
*
AS6
HP
Biventricular physiological heart failure pacemaker insertion DDD (R)
274.6
26.8
27
*
WX740
NOMESCO Finland
Nitrogen oxide therapy
141.9
26.7
28
*
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
4.2
26.3
104
260
FL1AC
NOMESCO Finland
Left cardioangiography
18.5
26.1
40
22
L04AA06
ATC
mycophenolic acid; systemic
6.1
25.8
71
119
E66.01
ICD-10 Finland
Obesity due to excess calories
3.0
25.7
157
554
A46
ICD-10 Finland
Erysipelas
2.2
25.6
300
1510
FM1JR
NOMESCO Finland
Heart, extensive metabolic PET with CT
44.9
25.5
31
7
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.6
25.1
192
778
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
9.8
24.8
50
52
A10BK03
ATC
empagliflozin; oral
2.8
24.6
168
635
TK800
NOMESCO Finland
Hemodialysis
5.2
24.5
77
152
C09AA04
ATC
perindopril; oral
3.3
24.4
127
400
I49.5
ICD-10 Finland
Sick sinus syndrome
4.5
24.0
87
200
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
87.8
23.7
26
*
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.8
22.2
97
266
B01AF01
ATC
rivaroxaban; oral
2.2
21.9
249
1229
FPG40
NOMESCO Finland
Replacement of pulse generator in transvenous cardioverter-defibrillator
60.7
20.9
24
*
4259X
ICD-9 Finland
Cardiomyopathy, Secondary cardiomyopathy, unspecified
+∞
20.9
20
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.0
20.8
282
1500
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.3
20.5
207
968
A10BA02
ATC
metformin; oral
1.7
20.4
511
3347
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
7.4
20.2
48
66
I42.6
ICD-10 Finland
Alcoholic cardiomyopathy
32.9
20.2
26
8
FPJ23
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with ventricular electrodes
+∞
19.8
19
*
103
Kela drug reimbursment
Diabetes, insulin-treated
1.7
19.8
495
3241
T90
ICPC
Diabetes non-insulin dependent
1.8
19.7
436
2750
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.7
19.3
66
144
I41.8*D86.8
ICD-10 Finland
Sarcoid myocarditis
46.5
19.2
23
5
E87.5
ICD-10 Finland
Hyperkalaemia
6.3
19.1
51
83
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
15.0
18.9
31
21
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.4
18.9
95
293
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
5.6
18.8
55
101
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.9
18.7
121
442
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
13.0
18.4
32
25
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
18.4
211
1042
K99
ICPC
Cardiovascular disease other
4.1
18.4
73
185
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
18.2
1337
15173
N18.8
ICD-10 Finland
Other chronic renal failure
4.1
18.2
71
177
C01DA14
ATC
isosorbide mononitrate; oral
3.7
18.2
80
222
3AC01
NOMESCO Finland
NA
7.7
17.9
41
54
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.9
17.8
294
1675
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.0
17.6
70
178
TFP35
NOMESCO Finland
Electroanatomical mapping
5.5
17.4
51
94
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
5.0
17.4
56
115
A11CC03
ATC
alfacalcidol; systemic
4.5
17.4
62
142
AA1AD
NOMESCO Finland
CT of head and brain
1.7
17.2
426
2765
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
17.1
502
3410
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.6
17.1
60
135
ATX
HP
Other pacemaker replacement or related action, such as cord removal or replacement
50.4
17.0
20
*
I47.1
ICD-10 Finland
Supraventricular tachycardia
3.2
16.9
92
301
FPG42
NOMESCO Finland
Replacement of electrode(s) in transvenous cardioverter-defibrillator
+∞
16.7
16
*
7AX01
NOMESCO Finland
NA
90.8
16.6
18
*
FXE00
NOMESCO Finland
Use of ECLA
90.8
16.6
18
*
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
6.0
16.5
45
76
XF600
NOMESCO Finland
Bloodpressure measurement
2.5
16.5
131
543
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
40.4
16.3
20
5
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
16.2
450
3010
FN1AD
NOMESCO Finland
CT of coronary arteries
7.7
16.1
37
49
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
5.1
16.1
51
103
WX722
NOMESCO Finland
PEEP
2.7
16.1
112
430
A10BH05
ATC
linagliptin; oral
2.9
16.1
99
352
62
HP
Catheterization and pressure measurement of the right side of the heart
30.3
16.1
21
7
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
6.8
16.0
40
60
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
13.7
16.0
27
20
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.3
16.0
160
744
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
9.0
15.9
33
37
C09CA03
ATC
valsartan; oral
2.1
15.9
179
879
FPE24
NOMESCO Finland
Implantation of biventricular cardiac pacemaker, ventricular electrodes, CRT-P (VVIR)
60.5
15.8
18
*
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
60.5
15.8
18
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.1
15.7
194
987
FPJ22
NOMESCO Finland
Revision of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
15.6
15
*
R03BB04
ATC
tiotropium bromide; inhalant
2.1
15.5
193
986
AQ1
HP
Conventional electrophysiological examination
7.1
15.4
37
53
E66.8
ICD-10 Finland
Other obesity
2.8
15.1
97
355
R2110
NOMESCO Finland
Giving the first information
2.7
15.0
105
405
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.0
15.0
193
999
I34.1
ICD-10 Finland
Mitral (valve) prolapse
3.5
14.8
68
197
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.3
14.5
140
641
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
14.4
289
1755
285
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.7
14.3
100
385
FPJ00
NOMESCO Finland
Revision of pacemaker pulse generator or electrode
22.4
14.2
20
9
T92
ICPC
Gout
4.0
13.9
55
140
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
5.9
13.9
38
65
E05.89
ICD-10 Finland
Other thyrotoxicosis
17.7
13.8
21
12
B01AE07
ATC
dabigatran etexilate; oral
2.8
13.7
86
311
A41.9
ICD-10 Finland
Sepsis, unspecified
3.1
13.7
75
248
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
9.1
13.7
28
31
M10
ICD-10 Finland
Gout
2.5
13.7
107
440
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
13.7
163
821
C10AA05
ATC
atorvastatin; oral
1.5
13.6
590
4364
WX930
NOMESCO Finland
Thepapeutic hypothermia
75.6
13.6
15
*
346
Kela drug reimbursment
Dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide (adults)
2.8
13.5
89
332
M01AH05
ATC
etoricoxib; oral
0.7
13.3
707
8792
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.8
13.2
87
324
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
5.5
13.2
38
70
FPJ
NOMESCO Finland
Review and replacement of pacemaker or internal defibrillator device or electrode
15.1
13.1
21
14
AP2
HP
Catheterization of the right side of the heart
16.8
13.0
20
12
A10BH01
ATC
sitagliptin; oral
2.0
13.0
172
902
61
HP
Catheterization and pressure measurement of the left side of the heart
13.1
12.9
22
17
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
19.2
12.9
19
10
N02BE01
ATC
paracetamol; systemic, rectal
1.5
12.9
1534
13811
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
12.9
342
2245
E66.00
ICD-10 Finland
Metabolic syndrome
2.4
12.8
108
462
TK810
NOMESCO Finland
Hemofiltration
8.1
12.8
28
35
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
12.3
12.6
22
18
I42.7
ICD-10 Finland
Cardiomyopathy due to drugs and other external agents
+∞
12.5
12
*
C01EB17
ATC
ivabradine; oral
+∞
12.5
12
*
63
HP
Cardiac muscle biopsy
+∞
12.5
12
*
AP3
HP
Catheterization of the right and left side of the heart
17.4
12.5
19
11
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
12.5
673
5187
R55
ICD-10 Finland
Syncope and collapse
1.9
12.4
182
992
FPW96
NOMESCO Finland
Other operation for arhythmia or disturbance of impulse propagation
11.7
12.3
22
19
R00.1
ICD-10 Finland
Bradycardia, unspecified
3.3
12.3
61
189
I44.1
ICD-10 Finland
Atrioventricular block, second degree
4.0
12.3
48
122
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
5.0
12.2
38
77
Z71.8
ICD-10 Finland
Other specified counselling
1.6
12.1
362
2443
I44.6
ICD-10 Finland
Other and unspecified fascicular block
26.9
12.0
16
6
EBA15
NOMESCO Finland
Extraction of large number of teeth
2.5
12.0
90
363
R03AC02
ATC
salbutamol; inhalant
1.4
11.9
836
6760
ARB
HP
Catheter ablation of arrhythmia: Cutiing or modification of the AV node
46.9
11.9
14
*
TFP44
NOMESCO Finland
Ablation treatment of typical atrial flutter
5.9
11.8
32
55
AS4
HP
Physiological pacemaker insertion DDD (R)
5.7
11.8
33
59
FA1AC
NOMESCO Finland
Upper cavography
65.3
11.6
13
*
H02AB07
ATC
prednisone; oral
1.7
11.6
236
1433
TFP32
NOMESCO Finland
Cathetric treatmen of cardiac arrythmia
8.7
11.5
24
28
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.5
11.5
87
352
ASA
HP
Insertion of a biventricular pacemaker VVI (R) S
+∞
11.5
11
*
283
Kela drug reimbursment
Ivabradine
+∞
11.5
11
*
B01AB04
ATC
dalteparin; parenteral
2.4
11.5
97
418
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
13.7
11.4
19
14
R1420
NOMESCO Finland
Assessment of rehabilitation needs and/or compilation of rehabilitation plan
120.7
11.4
12
*
FN1BB
NOMESCO Finland
Contrast angiography of heart and/or coronary arteries after bypass surgery
120.7
11.4
12
*
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.1
11.4
60
195
WX002
NOMESCO Finland
Sedation and analgesia
1.6
11.3
342
2315
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.3
11.3
103
459
73
HP
Initial pacemaker installation
10.6
11.3
21
20
I45.9
ICD-10 Finland
Conduction disorder, unspecified
6.2
11.2
29
47
J01MA14
ATC
moxifloxacin; systemic
1.9
11.2
156
832
R4190
NOMESCO Finland
Nutritional therapy
2.6
11.2
79
309
C09CA01
ATC
losartan; oral
1.5
11.1
402
2837
C01BC04
ATC
flecainide; systemic
2.7
11.1
75
286
3A064
NOMESCO Finland
NA
11.2
11.0
20
18
C08DA01
ATC
verapamil; systemic
2.7
10.9
72
268
Z73.3
ICD-10 Finland
Stress, not elsewhere classified
4.9
10.8
34
70
XA800
NOMESCO Finland
Neuropsychological investigation
2.4
10.8
87
366
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
3.0
10.8
62
213
M10.0
ICD-10 Finland
Idiopathic gout
2.6
10.7
78
308
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
4.3
10.7
38
89
71
HP
Electrophysiological Special Examination
7.6
10.7
24
32
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
10.6
167
932
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
2.1
10.6
116
562
R04.0
ICD-10 Finland
Epistaxis
2.1
10.6
125
626
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.8
10.6
43
114
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.6
10.5
75
295
TKC20
NOMESCO Finland
Catheterisation of bladder
2.0
10.5
131
673
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
+∞
10.4
10
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.0
10.4
138
725
FPJ21
NOMESCO Finland
Revision of cardioverter-defibrillator with ventricular electrode
32.7
10.3
13
*
H03BB01
ATC
carbimazole; oral
2.8
10.3
64
231
ZX108
NOMESCO Finland
Inhalation
5.8
10.3
28
49
74
HP
Initial installation of the atrial pacemaker
18.9
10.3
15
8
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
10.2
347
2408
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.9
10.2
158
879
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
10.1
453
3338
G47.3
ICD-10 Finland
Sleep apnoea
1.5
10.1
394
2821
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
6.5
10.0
25
39
WX902
NOMESCO Finland
External defibrillation of heart
9.2
10.0
20
22
WX882
NOMESCO Finland
High dependency care
2.9
10.0
60
214
I41.8
ICD-10 Finland
Myocarditis in other diseases classified elsewhere
40.3
10.0
12
*
S97
ICPC
Chronic ulcer skin
2.2
9.9
99
462
C10AA01
ATC
simvastatin; oral
1.4
9.8
676
5399
WVA40
NOMESCO Finland
Initiation and monitoring of intravenous hydration
4.6
9.7
32
70
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.4
9.7
77
323
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
3.7
9.5
40
110
J01MA12
ATC
levofloxacin; systemic
1.5
9.4
321
2227
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.7
9.4
178
1058
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.2
9.4
48
154
A41.8
ICD-10 Finland
Other specified sepsis
3.7
9.3
39
107
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.9
9.2
140
775
J01DB01
ATC
cefalexin; oral
1.4
9.1
1453
13209
E86
ICD-10 Finland
Volume depletion
3.1
9.1
47
152
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
2.6
9.1
66
264
G93.1
ICD-10 Finland
Anoxic brain damage, not elsewhere classified
15.6
9.0
14
9
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
2.2
8.9
88
411
J01CA04
ATC
amoxicillin; systemic
1.4
8.8
1357
12225
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
1.9
8.8
137
763
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.2
8.8
89
420
R4120
NOMESCO Finland
Occupational therapy
2.0
8.8
105
532
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
8.7
302
2104
A10BJ06
ATC
semaglutide; parenteral
2.7
8.7
59
226
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
8.7
438
3291
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
2.3
8.7
81
368
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
8.7
117
620
I95.9
ICD-10 Finland
Hypotension, unspecified
4.5
8.7
29
65
C03AA03
ATC
hydrochlorothiazide; oral
1.8
8.6
145
831
S18
ICPC
Laceration/cut
1.3
8.6
713
5833
A12AA04
ATC
calcium carbonate; oral
3.8
8.5
34
90
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
4.0
8.4
32
81
C01BA01
ATC
quinidine; oral
7.4
8.4
19
26
I51.3
ICD-10 Finland
Intracardiac thrombosis, not elsewhere classified
90.4
8.4
9
*
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
2.5
8.4
62
251
Z94.0
ICD-10 Finland
Kidney transplant status
4.2
8.4
30
72
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
2.2
8.3
86
409
FWA00
NOMESCO Finland
Repair of wound dehiscence in surgery of heart and major thoracic vessels
+∞
8.3
8
*
FPJ12
NOMESCO Finland
Revision of biventricular CRT-P (DDDR) generator
+∞
8.3
8
*
TFP52
NOMESCO Finland
Ablation treatment of ventricular tachycardia due to structural heart defect
+∞
8.3
8
*
FXM00
NOMESCO Finland
Removal of extra-, para- or intracorporeal VAD
+∞
8.3
8
*
SPAT1263
SPAT
Sampling
1.3
8.3
660
5359
R50.9
ICD-10 Finland
Fever, unspecified
1.6
8.3
221
1445
WX110
NOMESCO Finland
Local anesthesy
1.3
8.1
1166
10321
F1279
NOMESCO Finland
NA
33.5
8.1
10
*
C09AA01
ATC
captopril; oral
3.5
8.1
35
100
742
NOMESCO Finland
NA
10.1
8.0
15
15
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
5.9
8.0
21
36
N19
ICD-10 Finland
Unspecified kidney failure
2.5
7.9
58
234
M01AC06
ATC
meloxicam; systemic, rectal
0.7
7.9
355
4638
Z49.1
ICD-10 Finland
Extracorporeal dialysis
3.9
7.8
30
77
5AB14
NOMESCO Finland
NA
10.8
7.8
14
13
C02EA02
ATC
NA
2.2
7.8
72
327
C07AB03
ATC
atenolol; systemic
2.1
7.7
86
422
XF406
NOMESCO Finland
High resolution ECG
45.1
7.7
9
*
WX900
NOMESCO Finland
Resuscitation
15.1
7.7
12
8
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.7
7.7
159
971
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
7.7
597
4814
SPAT1325
SPAT
Vaccination
1.4
7.7
528
4178
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.2
7.6
74
345
Z50.0
ICD-10 Finland
Cardiac rehabilitation
11.9
7.6
13
11
XFP02
NOMESCO Finland
NA
25.1
7.6
10
*
FM1EE
SPAT
NA
6.2
7.5
19
31
A10BJ02
ATC
liraglutide; parenteral
2.8
7.5
45
162
G04BE03
ATC
sildenafil; oral
2.9
7.5
43
149
72
HP
Catheter ablation of arrhythmia
7.1
7.5
17
24
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
3.7
7.4
30
81
A28
ICPC
Limited function/disability NOS
1.6
7.4
221
1483
FM1BG
NOMESCO Finland
MRI examination of heart with high intensity magnet
80.4
7.4
8
*
160
Kela drug reimbursment
exenatide
2.9
7.4
41
141
WX890
NOMESCO Finland
Intesive care monitoring
6.5
7.4
18
28
K83
ICPC
Heart valve disease NOS
4.6
7.4
24
53
FPE26
NOMESCO Finland
Implantation of permanent biventricular pacemaker, transvenous route
+∞
7.3
7
*
AS2
HP
Ventricular pacemaker insertion VVI (R)
6.8
7.3
17
25
ZX197
NOMESCO Finland
NA
15.8
7.2
11
7
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
5.4
7.2
20
37
Z49.0
ICD-10 Finland
Preparatory care for dialysis
4.3
7.2
25
59
WX730
NOMESCO Finland
Conventional respirator
3.4
7.2
32
94
N17.8
ICD-10 Finland
Other acute renal failure
4.6
7.2
23
50
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
2.2
7.2
73
346
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.4
7.2
417
3206
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
2.5
7.2
53
214
FN1BD
NOMESCO Finland
Extensive CT of coronary arteries
20.1
7.1
10
5
B01AF03
ATC
edoxaban; oral
3.4
7.1
32
95
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.8
7.1
128
750
FM1CD
NOMESCO Finland
Very extensive CT of heart
7.9
7.1
15
19
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.6
7.1
144
2181
N18.0
ICD-10 Finland
End-stage renal disease
4.0
7.1
26
65
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
3.2
7.1
35
112
AQ2
HP
Electrophysiological electroanatomical examination
8.8
7.0
14
16
FPH96
NOMESCO Finland
Other removal of cardiac pacemaker or cardioverter-defibrillator
8.8
7.0
14
16
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.9
6.9
103
568
J01FF01
ATC
clindamycin; systemic
1.4
6.9
432
3357
K22
ICPC
Risk factor cardiovascular disease
2.0
6.9
85
438
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
1.8
6.9
115
658
M01AB05
ATC
diclofenac; systemic, rectal
0.8
6.8
902
10240
SPAT1255
SPAT
Intravenous administration of medicine
1.8
6.8
107
600
RS221
NOMESCO Finland
NA
3.3
6.8
32
99
3A149
NOMESCO Finland
NA
40.2
6.8
8
*
FPF00
NOMESCO Finland
Implantation of epicardial pacemaker with ventricular electrode
40.2
6.8
8
*
A02BC02
ATC
pantoprazole; systemic
1.3
6.8
1040
9180
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
3.3
6.7
31
94
SPAT1097
SPAT
Recording of ECG
1.5
6.7
219
1504
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
22.6
6.7
9
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.4
6.6
436
3414
K29
ICPC
Cardiovascular sympt/complt other
2.2
6.6
65
306
EBA00
NOMESCO Finland
Extraction of tooth
1.3
6.5
524
4232
L04AA01
ATC
[U] ciclosporin; systemic
3.5
6.5
28
81
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
4.0
6.5
24
61
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
6.5
110
635
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.5
6.4
204
1389
4271A
ICD-9 Finland
Cardiac dysrhythmias, Paroxysmal ventricular tachycardia
70.1
6.4
7
*
ZXA05
NOMESCO Finland
Left side
1.4
6.4
391
3024
5253
FHL
Cardiac lung machine
14.3
6.4
10
7
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.3
6.4
57
255
V03AE01
ATC
polystyrene sulfonate; oral
3.9
6.4
24
62
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
1.8
6.4
109
629
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.3
6.4
452
3581
5CM18
NOMESCO Finland
NA
8.2
6.3
13
16
212
Kela drug reimbursment
Gout
2.5
6.3
45
180
I47.0
ICD-10 Finland
Re-entry ventricular arrhythmia
11.0
6.3
11
10
I44.0
ICD-10 Finland
Atrioventricular block, first degree
3.6
6.3
26
73
WW500
NOMESCO Finland
Blood transfusion
2.1
6.3
65
314
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
18.1
6.3
9
5
K06.10
ICD-10 Finland
Gingival fibromatosis
+∞
6.3
6
*
ATB
HP
Replacement of biventricular, physiological pacemaker DDD (R) S
+∞
6.3
6
*
XX3BW
NOMESCO Finland
NA
+∞
6.3
6
*
354
Kela drug reimbursment
Ivabradine
+∞
6.3
6
*
AK1
HP
HTX (heart transplant)
+∞
6.3
6
*
WX720
NOMESCO Finland
Own respiration
2.3
6.2
52
228
AS5
HP
Biventricular heart failure pacemaker insertion VVI (R)
26.7
6.2
8
*
I51.4
ICD-10 Finland
Myocarditis, unspecified
7.0
6.2
14
20
205
Kela drug reimbursment
Chronic hypertension
1.3
6.2
428
3373
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.6
6.2
163
1065
K01
ICPC
Heart pain
5.0
6.2
18
36
WW200
NOMESCO Finland
Immunization
2.4
6.2
48
203
I45.3
ICD-10 Finland
Trifascicular block
6.3
6.2
15
24
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
5.3
6.1
17
32
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
7.7
6.1
13
17
I95.2
ICD-10 Finland
Hypotension due to drugs
7.7
6.1
13
17
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.4
6.1
247
1773
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
4.0
6.1
22
55
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
3.9
6.1
23
60
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.8
6.0
99
564
R00.0
ICD-10 Finland
Tachycardia, unspecified
2.3
6.0
53
239
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1666
4373
13.30
307.65
7.8
2.4
1921.1
1135.5
ng/l
7.93
1601
3615
720
1183
8.63
307.65
5.4
2.3
327.0
133.6
ng/l
16.84
692
1063
896
2147
6.42
307.65
3.3
2.4
23.7
24.1
%
0.33
812
1836
910
2291
6.14
307.65
3.3
2.3
2.3
2.3
g/l
2.78
878
2126
949
2460
6.10
307.65
3.3
2.4
14.2
13.6
umol/l
1.30
916
2282
221
258
9.43
176.85
3.0
2.7
0.8
0.8
nmol/l
0.78
179
200
272
427
7.14
169.03
1.8
2.1
10.8
11.5
mg/l
0.60
246
398
749
2951
3.36
144.39
5.1
2.9
397.2
235.3
ng/l
0.34
685
2291
1222
6417
3.08
142.35
3.8
2.6
197.6
169.4
ug/l
0.66
1169
5886
1282
6939
3.09
140.96
18.8
8.2
1.5
1.2
inr
12.19
336
1960
891
3946
3.14
140.11
2.7
2.1
2.7
2.9
mg/l
1.17
794
3324
614
2212
3.48
135.69
42.1
22.8
1.7
1.4
inr
3.66
72
329
308
725
4.79
122.79
1.8
2.0
31.1
38.9
u/l
6.27
197
642
678
2775
3.10
119.17
7.4
3.5
0.8
0.8
mmol/l
0.03
646
2613
478
1585
3.59
118.73
18.1
7.0
11.5
9.4
mmol/l
6.32
466
1514
1088
6214
2.51
94.68
4.9
2.8
28.8
27.2
ng/l
0.24
890
4355
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
230
567
4.42
85.52
8.0
3.0
0.4
0.3
u/ml
1.09
148
297
526
2279
2.73
79.10
10.4
5.9
1.1
1.0
mmol/l
6.14
495
2139
1325
8873
2.28
72.67
9.5
6.7
14.5
12.1
umol/l
6.96
1277
8444
450
1924
2.69
68.49
14.8
7.6
5.1
5.2
kpa
0.51
429
1839
324
1162
3.10
68.30
2.7
1.9
19.0
6.4
ug/l
2.90
299
1009
449
1925
2.68
67.92
14.8
7.6
11.3
12.4
kpa
5.05
425
1841
393
1579
2.82
67.41
6.5
3.8
1.6
2.0
mmol/l
0.89
316
1271
446
1921
2.67
66.74
14.9
7.6
0.7
0.9
mmol/l
0.61
358
1511
392
1581
2.81
66.70
6.5
3.8
5.9
5.8
kpa
0.33
377
1542
1257
8492
2.15
64.00
13.3
6.8
1.2
1.2
mmol/l
8.91
1095
7155
249
791
3.43
63.95
4.2
3.5
4.3
4.5
pmol/l
1.40
235
704
1171
7728
2.13
63.03
12.7
6.0
1.2
1.2
mmol/l
7.48
1101
6982
377
1535
2.76
62.72
16.0
7.2
1.5
1.4
mmol/l
1.22
362
1480
252
830
3.31
60.98
7.5
4.2
23.9
24.2
mmol/l
0.85
234
754
1415
10124
2.15
60.48
9.5
4.6
6.9
6.7
mmol/l
2.00
1369
9535
404
1740
2.63
59.93
16.1
7.9
94.9
95.7
%
1.44
392
1677
1100
7393
1.99
52.91
6.3
5.1
34.6
35.5
g/l
5.51
1045
6872
257
938
2.97
51.90
19.9
9.7
24.1
24.3
mmol/l
0.39
242
883
363
1600
2.53
50.70
17.5
8.4
123.8
123.7
g/l
0.03
354
1533
450
2213
2.31
49.08
15.4
7.1
104.1
104.5
mmol/l
0.76
443
2165
55
55
10.24
48.79
35.4
1.7
81.2
82.4
mg/l
0.02
48
44
518
2722
2.19
47.95
2.1
1.9
—
—
—
0
0
1176
8274
1.93
47.50
8.6
6.3
24.4
27.5
%
18.34
1129
7669
740
4481
1.99
46.51
6.6
4.2
73.3
88.8
%
33.77
726
4393
74
116
6.57
45.33
1.7
1.5
15.1
12.8
umol/l
1.76
74
106
408
2005
2.28
44.15
10.0
4.6
261.4
237.6
u/l
1.55
389
1900
1149
8170
1.87
43.38
8.4
6.1
60.2
57.3
%
13.45
1105
7619
481
2547
2.14
43.13
7.1
2.0
31.7
29.8
s
5.89
470
2463
1330
9919
1.89
43.03
11.1
9.6
4.4
4.2
e9/l
3.46
1157
8599
1664
13390
2.06
42.71
11.4
7.7
80.1
79.0
u/l
0.41
1597
12625
599
3504
1.98
40.59
6.1
1.6
1.7
1.4
mg/l
0.94
494
2692
207
776
2.84
39.48
1.7
1.8
1.6
1.5
g/l
0.71
180
673
292
1303
2.44
39.12
5.9
3.3
4.8
4.6
kpa
0.39
277
1271
835
5512
1.84
38.68
3.8
3.4
48.7
38.0
u/l
0.75
795
5225
745
4777
1.85
37.67
3.7
2.7
3184.9
5135.1
umol/l
0.75
665
4161
313
1464
2.33
37.63
2.0
2.6
63.7
66.5
g/l
6.66
290
1328
368
1848
2.20
37.27
2.0
1.8
—
—
—
0
0
227
926
2.62
36.67
23.5
10.2
—
—
—
0
0
152
499
3.20
36.57
7.2
2.6
3.7
3.6
g/l
0.25
146
473
367
1859
2.17
36.29
2.0
1.8
—
—
—
0
0
53
78
6.94
34.42
23.3
28.7
113.5
127.6
ug/l
0.59
34
67
91
239
3.93
30.72
10.3
6.4
10.8
11.2
mg/l
0.37
86
222
110
332
3.44
30.27
1.6
1.3
253.3
267.1
u/ml
0.21
85
200
77
182
4.35
29.92
1.4
1.1
93.6
96.9
%
0.39
77
170
114
356
3.33
29.73
1.6
1.3
—
—
—
0
0
81
201
4.15
29.54
1.5
1.4
14752.1
2613.8
e6/l
0.46
53
145
359
1939
2.02
29.49
2.5
2.7
1.9
1.7
%
2.26
328
1712
250
1184
2.26
28.83
6.4
3.9
125.4
87.1
ng/l
4.20
230
1040
323
1713
2.04
27.80
2.3
2.4
0.2
0.2
g/l
2.11
296
1603
83
220
3.88
27.67
1.4
1.4
27.0
33.8
g/l
4.56
66
201
731
5004
1.70
27.56
2.6
2.1
215.6
232.8
u/l
0.19
703
4721
27
22
12.42
27.26
1.2
1.0
65.0
73.2
ng/l
0.06
22
16
153
597
2.68
26.86
5.1
2.1
547.1
432.6
ug/l
0.31
148
563
73
184
4.07
26.09
1.5
1.4
26044.8
95099.1
e6/l
1.12
43
112
85
244
3.59
25.26
1.5
1.2
3.0
4.3
u/ml
0.95
44
107
100
319
3.24
25.20
1.9
1.4
118.6
118.0
u/ml
0.01
12
58
73
192
3.90
24.62
1.1
1.1
—
—
—
0
0
215
1020
2.23
24.57
6.1
3.0
131.6
132.0
g/l
0.09
206
998
84
248
3.48
23.93
1.4
1.1
—
—
—
0
0
340
1928
1.91
23.88
2.9
3.2
9.8
9.1
umol/l
0.27
306
1724
1472
12282
1.62
23.30
4.3
3.5
15.3
14.8
pmol/l
10.19
1370
11035
82
248
3.40
22.51
1.5
1.2
2.7
3.8
u/ml
0.31
31
88
105
374
2.90
21.89
9.9
6.3
997.0
4582.9
iu/ml
0.42
24
55
113
419
2.79
21.87
2.3
3.2
32.3
38.5
umol/l
1.20
99
356
744
5392
1.58
20.99
3.7
3.3
103.4
89.2
e6/l
0.14
581
4180
207
1032
2.11
20.79
1.8
1.6
—
—
—
0
0
229
1188
2.04
20.67
1.6
1.6
—
—
—
0
0
219
1130
2.04
20.05
5.5
4.0
1.8
1.7
mmol/l
0.18
158
829
683
4898
1.58
19.95
3.6
3.2
0.6
0.4
e6/l
1.01
520
3701
153
691
2.31
19.60
2.3
1.9
11.6
3.7
ug/l
0.40
138
606
43
90
4.85
19.44
1.2
1.1
—
—
—
0
0
1736
15362
1.66
19.07
5.3
4.1
2.0
2.2
mu/l
0.61
1625
13887
593
4156
1.59
18.94
3.1
2.4
—
—
—
0
0
1912
17392
1.87
18.89
25.9
13.6
25.2
25.9
mg/l
0.40
1704
13691
94
343
2.82
18.77
1.3
1.3
—
—
—
0
0
94
343
2.82
18.77
1.3
1.3
—
—
—
0
0
223
1187
1.98
18.68
5.6
4.0
5.2
5.1
kpa
0.10
212
1099
199
1019
2.05
18.57
10.3
7.0
24.4
24.6
mmol/l
0.26
185
944
1981
18266
2.03
18.27
36.3
15.3
139.5
139.7
mmol/l
4.56
1959
17798
165
794
2.17
18.12
4.4
3.2
24.6
25.1
mmol/l
1.07
158
772
744
5531
1.53
18.09
3.7
3.3
7.4
8.2
mmol/l
6.22
643
4631
30
48
6.32
18.02
1.1
1.0
—
—
—
0
0
119
505
2.44
17.55
1.8
2.2
0.0
0.0
g/l
1.00
106
463
1981
18329
1.98
17.11
36.8
15.4
4.1
4.0
mmol/l
37.03
1960
17833
137
629
2.26
16.88
1.7
2.3
3.1
3.1
g/l
0.01
115
503
143
669
2.22
16.84
1.7
2.3
3.7
3.8
g/l
0.24
113
488
255
1467
1.84
16.82
2.3
2.9
72.3
67.2
e9/l
1.08
179
1133
143
670
2.21
16.78
1.7
2.3
—
—
—
0
0
143
671
2.21
16.72
1.7
2.3
7.2
7.3
g/l
0.20
116
512
136
632
2.23
16.28
1.7
2.3
9.9
10.4
g/l
0.66
121
538
110
468
2.42
16.14
1.8
2.2
0.0
0.0
g/l
0.00
98
433
112
481
2.40
16.10
5.5
4.3
4.1
3.9
mmol/l
3.09
106
453
428
2871
1.61
16.08
3.2
3.1
2.7
1.5
e6/l
1.26
217
1550
730
5509
1.49
16.07
4.5
4.0
13.6
9.0
mg/mmol
1.56
519
3584
111
476
2.40
16.01
1.8
2.2
0.0
0.0
g/l
0.00
98
434
989
7927
1.46
15.96
4.5
4.1
—
—
—
0
0
556
3976
1.54
15.77
1.7
1.5
19.3
20.5
nmol/l
1.22
502
3368
267
1591
1.77
15.63
2.2
2.6
41.4
69.8
u/l
0.46
230
1376
21
27
7.84
15.30
6.8
6.6
—
—
—
0
0
55
166
3.37
15.22
1.3
1.3
5.7
6.3
mmol/l
0.69
49
151
523
3718
1.54
15.16
2.9
2.5
4.5
4.4
e6/l
0.05
465
3289
885
6997
1.45
15.09
2.1
1.9
94.4
94.3
pmol/l
0.03
515
3770
702
5316
1.47
14.95
3.3
2.6
60.5
59.2
u/l
0.20
668
4906
1287
10922
1.44
14.82
4.6
4.1
402.9
1999.8
e6/l
1.14
20
156
442
3043
1.57
14.74
3.1
2.9
1.2
0.9
e6/l
0.48
231
1715
111
495
2.31
14.66
6.2
4.1
1.8
1.5
mg/l
4.29
103
457
124
583
2.20
14.44
1.8
2.5
0.2
1.3
g/l
4.23
108
502
116
535
2.23
14.16
1.8
2.1
35.8
37.7
g/l
2.18
99
457
180
989
1.89
13.66
1.4
1.4
—
—
—
0
0
113
526
2.21
13.49
1.7
1.7
—
—
—
0
0
102
455
2.30
13.48
1.2
1.2
—
—
—
0
0
86
363
2.43
12.88
1.8
2.2
137.4
130.1
g/l
1.40
50
248
96
429
2.30
12.65
1.6
2.0
—
—
—
0
0
98
442
2.28
12.64
1.6
1.5
1.2
1.2
g/l
0.19
90
420
95
426
2.29
12.42
1.6
1.5
0.2
0.2
g/l
0.49
86
407
42
123
3.46
12.22
1.3
1.3
18.1
12.6
u/l
0.19
34
114
102
475
2.20
12.19
1.5
1.3
—
—
—
0
0
42
127
3.35
11.65
1.5
1.2
—
—
—
0
0
32
81
4.00
11.48
1.7
2.0
—
—
—
0
0
75
1618
0.44
11.22
1.4
1.8
—
—
—
0
0
90
415
2.22
11.04
1.6
2.0
—
—
—
0
0
24
50
4.84
10.96
1.7
2.3
6022.5
1138.3
e6/l
1.86
16
32
79
346
2.33
10.94
2.1
2.5
17.3
16.3
%
0.90
38
181
715
5682
1.39
10.87
3.9
3.5
2.3
2.3
mmol/l
1.53
624
4930
110
553
2.04
10.82
2.0
3.5
30.0
65.2
mg/l
0.90
92
443
110
553
2.04
10.82
2.0
3.5
52.9
59.1
mg/l
0.18
94
441
1431
12695
1.38
10.76
5.0
3.9
14.7
11.6
mm/h
10.21
1352
11720
141
779
1.87
10.54
7.0
4.5
24.6
24.8
mmol/l
0.23
135
729
218
1366
1.66
10.53
3.1
2.5
57.6
67.0
ml/min/173m2
3.19
95
525
119
623
1.96
10.45
2.9
2.7
—
—
—
0
0
133
723
1.89
10.45
2.2
2.0
—
—
—
0
0
10
0
+∞
10.42
1.2
0.0
—
—
—
0
0
1810
16778
1.49
10.24
25.7
12.7
74.8
80.9
ml/min/173m2
21.03
1630
13861
106
541
2.01
10.02
2.0
3.4
1.6
2.9
ratio
—
6
48
83
386
2.20
10.00
1.6
1.6
—
—
—
0
0
60
248
2.46
9.48
1.6
1.8
1.7
1.6
mmol/l
0.42
60
241
1576
14337
1.37
9.21
32.1
16.6
14.1
13.6
%
21.06
1554
13991
420
3123
1.43
9.17
1.8
1.7
1183.7
1146.7
nmol/l
0.32
337
2324
89
441
2.06
9.14
3.2
3.1
24.2
24.9
mmol/l
0.61
82
378
16
28
5.75
8.80
1.4
1.1
1.0
1.1
mmol/l
—
8
22
1759
16336
1.41
8.75
6.8
5.5
41.4
39.6
mmol/mol
11.92
1667
15048
119
666
1.83
8.58
2.1
1.8
—
—
—
0
0
14
22
6.40
8.53
1.4
1.1
30.6
54.2
u/l
—
7
16
93
490
1.94
8.08
1.4
1.3
—
—
—
0
0
72
347
2.11
7.99
1.5
1.8
210.5
5.7
iu/l
0.47
15
116
20
47
4.29
7.94
1.5
1.4
28.6
27.1
%
0.07
13
39
219
1472
1.54
7.88
2.7
2.4
393.8
367.8
nmol/l
1.10
209
1362
66
320
2.10
7.24
1.7
2.1
—
—
—
0
0
85
454
1.91
7.13
1.2
1.1
—
—
—
0
0
46
195
2.39
6.97
1.6
2.1
—
—
—
0
0
15
31
4.87
6.93
3.4
5.3
—
—
—
0
0
12
20
6.03
6.90
7.5
10.8
4.6
6.7
mmol/l
2.03
12
20
63
307
2.08
6.84
1.3
1.6
—
—
—
0
0
47
205
2.32
6.69
1.7
1.9
—
—
—
0
0
50
225
2.25
6.63
1.7
1.9
17.4
25.8
ug/l
0.83
50
225
83
452
1.87
6.59
1.2
1.1
—
—
—
0
0
27
90
3.03
6.50
1.7
2.7
—
—
—
0
0
27
90
3.03
6.50
1.7
2.7
—
—
—
0
0
27
90
3.03
6.50
1.7
2.7
—
—
—
0
0
27
90
3.03
6.50
1.7
2.7
—
—
—
0
0
54
254
2.15
6.44
1.4
1.7
—
—
—
0
0
42
183
2.32
6.03
1.7
2.2
—
—
—
0
0
770
6597
1.26
5.95
2.6
2.2
74.0
76.8
nmol/l
1.82
701
5875
25
87
2.90
5.62
1.5
2.0
—
—
—
0
0
25
87
2.90
5.62
1.5
2.0
—
—
—
0
0
191
1345
1.46
5.52
2.8
2.8
10.9
10.7
g/l
0.20
182
1225
662
7712
0.80
5.51
3.4
4.1
24.1
21.4
%
3.66
298
3746
36
153
2.38
5.49
1.5
2.1
—
—
—
0
0
36
153
2.38
5.49
1.5
2.1
—
—
—
0
0
36
153
2.38
5.49
1.5
2.1
—
—
—
0
0
304
2333
1.35
5.34
1.8
1.9
1.6
1.5
%
2.14
257
2054
77
440
1.78
5.30
1.6
1.6
23768.0
15007.5
e6/l
0.40
51
304
108
677
1.63
5.30
8.5
5.3
1.7
1.7
%
0.28
101
634
110
700
1.60
5.09
1.3
1.3
—
—
—
0
0
44
212
2.10
5.01
1.1
1.1
—
—
—
0
0
69
396
1.77
4.71
1.2
1.1
—
—
—
0
0
158
2193
0.70
4.52
2.5
2.3
11.9
13.6
nmol/l
1.71
137
1957
48
249
1.95
4.50
1.3
1.6
—
—
—
0
0
1789
17097
1.27
4.21
5.3
4.4
6.3
6.0
mmol/l
16.93
1651
15471
12
32
3.77
4.08
1.5
1.1
—
—
—
0
0
1755
16756
1.25
4.02
4.6
3.8
1.5
1.3
mmol/l
13.33
1649
15227
319
2567
1.28
3.98
1.2
1.2
72.1
29.9
iu/ml
1.54
84
786
63
372
1.71
3.95
1.5
1.7
—
—
—
0
0
864
9578
0.84
3.94
3.9
4.9
2.6
3.5
ug/l
1.04
767
8642
237
1838
1.33
3.89
4.1
3.2
—
—
—
0
0
376
3103
1.26
3.81
3.0
3.2
2.5
2.4
mmol/l
0.36
327
2742
67
408
1.66
3.77
1.4
1.3
—
—
—
0
0
69
425
1.64
3.72
1.6
1.7
—
—
—
0
0
494
5745
0.82
3.71
2.6
3.0
0.8
0.8
ug/l
0.42
363
3764
7
9
7.80
3.56
1.6
1.2
—
—
—
0
0
47
265
1.79
3.49
1.3
1.5
—
—
—
0
0
273
2191
1.28
3.48
13.5
6.0
—
—
—
0
0
27
125
2.17
3.48
1.7
2.6
—
—
—
0
0
7
10
7.02
3.36
2.7
4.3
—
—
—
0
0
30
148
2.04
3.31
1.1
1.1
—
—
—
0
0
38
204
1.88
3.31
1.3
1.6
60.1
59.0
%
0.05
23
130
31
156
2.00
3.25
1.7
1.8
—
—
—
0
0
42
235
1.80
3.22
1.1
1.1
—
—
—
0
0
1812
17475
1.23
3.11
5.0
4.2
4.4
4.7
mmol/l
38.34
1716
16087
28
139
2.03
3.06
1.5
2.7
15.7
13.6
%
0.20
15
65
179
1383
1.32
3.05
4.5
3.9
1.2
1.2
mmol/l
1.74
166
1211
41
233
1.77
3.01
1.3
1.5
—
—
—
0
0
44
256
1.73
2.98
1.2
1.1
—
—
—
0
0
17
69
2.48
2.96
1.8
3.1
—
—
—
0
0
17
69
2.48
2.96
1.8
3.1
—
—
—
0
0
14
52
2.70
2.89
1.1
1.2
—
—
—
0
0
17
70
2.44
2.88
1.8
3.1
—
—
—
0
0
31
164
1.90
2.85
1.5
1.3
29291.5
84325.4
e6/l
0.68
21
119
1797
17351
1.21
2.84
4.9
4.2
1.3
1.4
mmol/l
36.94
1690
15875
891
8164
1.16
2.76
5.1
4.5
0.0
0.0
estimate
0.50
169
1576
1940
18896
1.26
2.74
16.1
10.1
29.7
28.2
u/l
1.54
1895
18193
1258
11820
1.15
2.73
4.0
3.2
74.3
54.0
u/l
5.96
1181
11004
16
66
2.43
2.71
2.1
2.3
—
—
—
0
0
899
8258
1.15
2.66
3.8
3.3
0.0
0.0
estimate
1.23
160
1489
29
157
1.86
2.52
1.1
1.2
211.2
64.8
u/l
0.65
21
106
19
88
2.17
2.51
1.2
1.3
1.7
1.2
nmol/l
0.71
14
66
8
21
3.82
2.46
3.4
1.7
110.3
170.2
ng/l
—
8
21
13
51
2.56
2.44
1.1
1.1
57.1
86.8
%
—
8
32
20
96
2.09
2.43
1.2
1.5
—
—
—
0
0
35
205
1.72
2.38
1.2
1.6
—
—
—
0
0
35
206
1.71
2.34
1.2
1.6
—
—
—
0
0
35
206
1.71
2.34
1.2
1.6
—
—
—
0
0
51
331
1.55
2.33
2.8
3.7
5.0
4.2
e9/l
0.94
51
331
883
8157
1.14
2.32
3.8
3.3
0.0
0.0
estimate
0.00
166
1543
35
209
1.69
2.23
1.2
1.6
—
—
—
0
0
29
165
1.77
2.19
4.2
2.8
—
—
—
0
0
35
211
1.67
2.17
1.2
1.6
—
—
—
0
0
47
306
1.55
2.14
2.4
3.9
2.0
1.5
%
0.35
40
232
51
339
1.52
2.12
3.1
4.1
62.2
57.9
%
1.48
51
339
10
37
2.71
2.10
1.7
2.6
—
—
—
0
0
30
176
1.71
2.06
1.0
1.0
—
—
—
0
0
67
474
1.43
2.06
1.3
1.8
—
—
—
0
0
19
96
1.99
2.05
1.2
1.5
—
—
—
0
0
1834
17855
1.18
2.05
5.5
4.6
2.6
2.8
mmol/l
28.23
1731
16335
63
441
1.44
2.05
2.3
2.3
98.6
100.9
ug/min
0.02
36
268
13
56
2.33
2.05
1.8
2.2
—
—
—
0
0
69
492
1.42
2.03
1.4
1.7
—
—
—
0
0
121
952
1.29
1.90
1.4
1.3
194.6
266.3
u/ml
0.73
115
871
49
333
1.48
1.87
1.1
1.1
—
—
—
0
0
6
17
3.54
1.84
1.2
1.7
—
—
—
0
0
33
207
1.60
1.80
1.2
1.6
—
—
—
0
0
33
207
1.60
1.80
1.5
1.3
0.2
0.4
nmol/l
—
10
18
36
231
1.57
1.79
1.2
1.3
—
—
—
0
0
18
95
1.90
1.75
1.8
1.7
3.6
6.4
u/l
0.59
11
47
23
132
1.75
1.73
1.4
1.6
—
—
—
0
0
56
398
1.42
1.72
2.8
1.7
1.3
0.8
nmol/l
3.92
48
333
30
188
1.60
1.66
1.1
1.4
349.8
275.5
pmol/l
0.44
21
152
31
196
1.59
1.66
2.5
4.1
63.0
53.8
%
1.75
24
124
24
142
1.70
1.64
1.1
1.4
—
—
—
0
0
14
69
2.04
1.64
1.1
1.1
159.0
195.9
iu/ml
0.29
14
69
486
4412
1.13
1.61
4.1
3.6
0.0
0.0
estimate
0.33
153
1482
8
32
2.51
1.59
1.6
1.1
119.5
97.7
%
—
8
32
8
32
2.51
1.59
1.6
1.1
—
—
—
0
0
69
517
1.35
1.57
1.5
1.6
0.1
1.8
iu/ml
0.55
12
90
71
537
1.33
1.53
1.3
1.2
0.1
0.7
u/ml
—
6
41
18
100
1.81
1.53
1.3
1.6
—
—
—
0
0
7
27
2.60
1.51
1.9
2.3
1.2
1.2
mmol/l
—
7
27
6
21
2.86
1.50
1.3
1.2
—
—
—
0
0
23
139
1.66
1.48
2.2
3.1
378.3
602.4
e6/l
1.55
16
121
65
489
1.34
1.46
1.4
1.4
265.5
270.2
ug/g
0.06
43
295
33
219
1.51
1.46
1.8
2.4
660.2
2819.6
u/l
0.83
14
80
9
38
2.37
1.45
1.6
1.3
—
—
—
0
0
49
353
1.40
1.44
1.2
1.5
—
—
—
0
0
79
614
1.30
1.42
4.7
1.7
8.6
4.3
mg/l
1.17
71
445
49
354
1.39
1.42
1.1
1.3
193.2
215.0
miu/ml
0.17
13
152
15
81
1.86
1.40
1.2
1.5
—
—
—
0
0
15
81
1.86
1.40
1.2
1.5
—
—
—
0
0
10
46
2.18
1.40
1.3
1.5
19.4
14.4
pmol/l
—
10
39
7
29
2.42
1.39
2.9
2.2
—
—
—
0
0
19
112
1.70
1.35
1.4
1.2
9.4
12.3
mmol/l
—
7
38
17
101
1.69
1.19
1.4
1.6
—
—
—
0
0
0
33
0.00
1.16
0.0
1.7
—
—
—
0
0
12
65
1.85
1.13
2.3
1.5
—
1075525.0
—
0
6
272
2445
1.13
1.08
1.2
1.2
16.6
11.6
u/ml
0.48
104
950
16
97
1.65
1.06
1.5
1.6
—
—
—
0
0
22
145
1.52
1.06
1.4
1.7
—
—
—
0
0
25
170
1.48
1.04
1.4
1.6
—
—
—
0
0
5
22
2.28
1.03
1.0
1.0
—
—
—
0
0
44
575
0.76
1.02
2.1
1.8
—
—
—
0
0
55
431
1.28
1.00
1.1
1.2
—
39.2
—
0
17
0
29
0.00
0.97
0.0
1.1
—
53.2
—
0
29
11
187
0.59
0.97
3.7
3.9
27.7
32.0
u/ml
0.12
11
182
18
116
1.56
0.96
1.0
1.0
—
—
—
0
0
18
116
1.56
0.96
1.4
1.6
—
—
—
0
0
19
126
1.51
0.91
2.4
1.6
—
—
—
0
0
24
168
1.43
0.89
1.0
1.4
36.0
28.6
%
0.54
16
106
5
105
0.47
0.88
1.2
1.4
—
—
—
0
0
5
105
0.47
0.88
1.2
1.4
—
—
—
0
0
5
105
0.47
0.88
1.2
1.4
—
—
—
0
0
5
105
0.47
0.88
1.2
1.4
—
—
—
0
0
28
203
1.38
0.87
4.0
3.9
—
—
—
0
0
1986
19651
1.13
0.85
38.3
19.9
231.2
243.4
e9/l
13.83
1952
19118
1987
19663
1.13
0.84
38.3
19.8
4.5
4.6
e12/l
12.82
1954
19069
59
721
0.81
0.83
3.5
3.6
1003.1
3651.6
u/ml
0.76
47
619
6
113
0.53
0.83
1.2
1.6
—
—
—
0
0
113
1302
0.86
0.83
1.4
1.4
—
—
—
0
0
1987
19667
1.13
0.82
38.3
19.9
7.1
6.7
e9/l
10.72
1955
19064
1987
19668
1.13
0.81
38.5
20.0
135.7
138.6
g/l
12.56
1967
19351
18
259
0.69
0.80
1.4
1.1
0.4
2.0
u/ml
—
9
112
11
66
1.67
0.78
1.8
1.4
14.6
9.0
ug/l
0.40
11
60
1049
10147
1.07
0.78
2.6
2.7
—
—
—
0
0
6
34
1.77
0.76
1.2
1.1
—
—
—
0
0
9
53
1.70
0.75
1.6
1.2
—
—
—
0
0
12
75
1.60
0.75
1.1
1.7
—
—
—
0
0
9
54
1.67
0.74
3.9
2.3
—
—
—
0
0
9
54
1.67
0.74
3.9
2.3
—
—
—
0
0
12
76
1.58
0.71
2.3
2.2
161.7
139.0
nmol/l
0.33
12
66
11
170
0.65
0.70
1.0
1.1
—
—
—
0
0
29
376
0.77
0.69
5.3
2.7
23.8
28.7
mg/l
0.51
20
216
355
3322
1.08
0.68
1.2
1.2
2.1
2.1
u/ml
0.03
70
842
50
412
1.22
0.66
1.1
1.2
2.0
8.2
u/ml
—
10
52
21
282
0.74
0.65
1.3
1.4
—
—
—
0
0
15
103
1.46
0.65
1.2
1.1
—
—
—
0
0
14
95
1.48
0.64
1.3
1.8
—
—
—
0
0
49
407
1.21
0.61
1.1
1.2
4.3
2.4
u/ml
—
7
26
8
51
1.57
0.60
1.0
1.1
—
—
—
0
0
8
51
1.57
0.60
1.0
1.1
—
—
—
0
0
6
37
1.62
0.55
1.0
1.1
—
—
—
0
0
8
126
0.63
0.54
1.0
1.0
222.4
316.6
mg/l
—
8
111
9
63
1.43
0.52
1.0
1.0
1197.7
1552.0
miu/ml
—
9
63
613
6354
0.95
0.49
4.1
3.4
—
—
—
0
0
55
474
1.16
0.49
1.6
1.5
10.7
7.3
u/l
0.81
44
384
17
128
1.33
0.47
1.4
1.2
—
—
—
0
0
7
49
1.43
0.46
1.4
1.2
117.9
108.8
%
—
7
41
8
120
0.67
0.45
1.0
1.0
—
—
—
0
0
5
84
0.59
0.45
1.4
2.3
63.0
53.6
umol/l
—
5
69
33
393
0.84
0.43
1.6
1.5
170.3
29.5
e6/l
0.40
26
301
33
393
0.84
0.43
1.6
1.6
148.2
1000.1
e6/l
1.16
28
312
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
8
59
1.36
0.41
1.1
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
12
88
1.37
0.40
1.0
1.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
0.1
—
0
11
13
99
1.32
0.35
1.0
1.2
—
—
—
0
0
13
99
1.32
0.35
1.0
1.2
—
—
—
0
0
240
2281
1.06
0.35
4.9
4.3
30.0
31.0
%
0.73
185
1475
37
426
0.87
0.34
1.3
1.1
13.4
7.7
u/ml
—
7
47
1615
15988
1.04
0.33
32.6
14.5
40.4
40.6
%
0.53
1154
11539
13
100
1.30
0.33
1.0
1.1
—
—
—
0
0
6
87
0.69
0.33
1.0
1.5
—
—
—
0
0
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
47
417
1.13
0.32
1.2
1.2
—
—
—
0
0
21
174
1.21
0.31
1.6
1.3
—
—
—
0
0
50
447
1.12
0.30
1.8
2.1
—
—
—
0
0
224
2345
0.95
0.29
1.4
1.4
—
—
—
0
0
12
150
0.80
0.27
1.2
1.0
0.8
0.6
u/ml
—
5
43
17
202
0.84
0.24
1.1
1.2
8.1
7.2
mmol/l
0.50
11
151
25
217
1.15
0.24
1.0
1.1
3.0
2.9
u/ml
—
7
91
6
81
0.74
0.24
1.0
1.2
—
—
—
0
0
14
115
1.22
0.23
1.1
1.2
—
—
—
0
0
16
190
0.84
0.23
1.3
1.6
—
—
—
0
0
5
40
1.25
0.22
1.0
1.0
—
—
—
0
0
5
41
1.22
0.22
1.6
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
31
277
1.12
0.21
2.2
2.9
3.7
254.9
u/ml
0.97
31
269
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
24
272
0.88
0.20
1.4
1.6
—
—
—
0
0
6
49
1.23
0.20
1.0
1.0
—
—
—
0
0
6
50
1.20
0.19
1.0
1.1
—
—
—
0
0
7
60
1.17
0.17
1.3
1.3
—
—
—
0
0
7
61
1.15
0.17
1.1
2.3
—
—
—
0
0
184
1903
0.96
0.17
3.7
4.5
10.6
27.7
ug/l
1.48
155
1572
113
1180
0.96
0.16
2.0
1.9
—
—
—
0
0
363
3558
1.02
0.15
1.7
1.7
31715644.1
26214342.3
pmol/l
0.06
309
2945
12
139
0.86
0.14
4.7
5.4
32.8
38.5
u/ml
—
6
40
31
287
1.08
0.12
1.1
1.1
334.8
83.0
iu/ml
—
5
68
11
127
0.87
0.12
10.8
14.1
1007.0
802.6
nmol/l
0.59
11
121
11
95
1.16
0.11
1.3
3.1
—
—
—
0
0
40
424
0.94
0.11
1.6
1.4
31.6
27.2
iu/l
0.29
30
350
32
299
1.07
0.10
5.3
5.2
350.9
354.5
umol/l
0.05
27
265
28
261
1.07
0.10
1.4
1.4
—
—
—
0
0
10
87
1.15
0.09
3.9
3.7
—
—
—
0
0
6
54
1.11
0.09
1.0
1.1
—
—
—
0
0
6
55
1.09
0.09
1.0
1.2
—
—
—
0
0
12
134
0.89
0.08
1.8
1.9
2.3
1.7
u/field
—
7
52
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
6
71
0.84
0.07
1.0
1.0
—
—
—
0
0
11
98
1.12
0.07
1.0
1.1
—
—
—
0
0
42
402
1.05
0.07
1.4
1.4
3.7
3.7
mmol/l
0.06
37
378
44
422
1.04
0.07
2.5
3.9
410.5
958.1
u/ml
0.38
39
386
13
118
1.10
0.07
1.1
1.1
—
—
—
0
0
13
118
1.10
0.07
1.1
1.1
—
—
—
0
0
9
86
1.05
0.07
1.1
1.2
—
—
—
0
0
71
727
0.98
0.05
1.0
1.0
—
—
—
0
0
13
120
1.08
0.05
1.1
1.1
—
—
—
0
0
13
120
1.08
0.05
1.1
1.1
—
—
—
0
0
13
120
1.08
0.05
1.1
1.1
—
—
—
0
0
350
3526
0.99
0.04
4.6
3.5
1.0
1.0
kg/l
1.61
39
490
17
160
1.06
0.04
1.5
1.4
—
—
—
0
0
37
359
1.03
0.03
1.8
2.1
—
—
—
0
0
185
1838
1.01
0.02
2.1
2.5
138.3
158.9
ug/g
0.44
152
1473
87
863
1.01
0.01
1.2
1.2
101.0
123.9
iu/ml
0.27
24
306
12
114
1.05
0.00
1.3
1.6
0.9
1.0
g/l
0.46
12
114
460
4608
1.00
0.00
1.5
1.6
1.5
1.4
mmol/l
1.45
403
3849
18
175
1.03
0.00
1.1
1.3
—
—
—
0
0
107
1066
1.00
0.00
1.9
1.8
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
10
103
0.97
0.00
1.0
1.2
—
—
—
0
0
9
90
1.00
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
8.4
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
75
0.93
0.00
1.4
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
69
0.87
0.00
4.0
3.2
—
—
—
0
0
5
51
0.98
0.00
2.4
1.3
8.9
8.4
ug/l
—
5
51
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
1475.5
—
0
6
0
9
0.00
0.00
0.0
8.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.8
—
0
5
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
6.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_NONISCHCARDMYOP_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_NONISCHCARDMYOP_STRICT | 2.931 [2.56, 3.36] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.147 |
During the follow-up period (1.1.1998 — 31.12.2019), 1023 out of 3592 females with I9_NONISCHCARDMYOP_STRICT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_NONISCHCARDMYOP_STRICT | 2.704 [2.44, 2.99] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 2926 out of 8846 males with I9_NONISCHCARDMYOP_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have I9_NONISCHCARDMYOP_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.239% | 0.397% |
| 5 | 1.68% | 2.752% |
| 10 | 3.951% | 7.339% |
| 15 | 7.703% | 13.927% |
| 20 | 13.295% | 22.847% |
Relationships between endpoints
↥Index endpoint: I9_NONISCHCARDMYOP_STRICT – Nonischemic cardiomyopathy
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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