appendicitis: Acute inflammation of the vermiform appendix.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
9164 |
4. Check minimum number of eventsNone |
9164 |
5. Include endpointsNone |
9164 |
6. Filter based on genotype QC (FinnGen only) |
9164 |
Control definitions (FinnGen only)
- Control exclude
- K11_APPENDIX
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Acute appendicitis, with complications
based on the number of shared cases.
Similar with more cases:
- Acute appendicitis
- Appendicitis, broad definition
- Diseases of appendix
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 84045 | 36878 | 46560 |
| Only index persons | 72602 | 32822 | 39780 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.19 | 1.06 | 1.30 |
| Only index persons | 1.38 | 1.21 | 1.52 |
| Median age at first event (years) | |||
| Whole population | 33.29 | 33.34 | 32.99 |
| Only index persons | 30.31 | 30.74 | 29.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 9164 | 4436 | 4728 |
| Unadjusted period prevalence (%) | 1.81 | 1.51 | 2.08 |
| Median age at first event (years) | 33.67 | 30.89 | 36.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 8367
- Matched controls
- 83666
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
54001
ICD-8 Finland
Acute appendicitis, Cum peritonitide diffusa
+∞
323.0
421
*
54003
ICD-8 Finland
Acute appendicitis, Cum abscessu
+∞
323.0
412
*
K35.0
ICD-10 Finland
Acute appendicitis with generalized peritonitis
13334.6
323.0
2050
*
K35.9
ICD-10 Finland
Acute appendicitis, unspecified
526.0
323.0
1521
35
54000
ICD-8 Finland
Acute appendicitis, Perforans
+∞
323.0
611
*
5400B
ICD-9 Finland
Acute appendicitis, With generalised peritonitis[APPENDICITIS ACUTA CUM PERITONITIDE CIRCUMSCRIPTA]
+∞
323.0
477
*
JEA01
NOMESCO Finland
Laparoscopic appendectomy
75.4
323.0
1275
199
54091
ICD-8 Finland
Acute appendicitis, Gangraenosa, peritonitide non indicata
+∞
323.0
1841
*
54002
ICD-8 Finland
Acute appendicitis, Cum peritonitide circumscripta
+∞
323.0
329
*
5401A
ICD-9 Finland
Acute appendicitis, With peritoneal abscess
+∞
323.0
426
*
JEA00
NOMESCO Finland
Appendectomy
28.5
323.0
1723
754
6421
FHL
Appendicectomy
19.7
323.0
1227
724
K35.1
ICD-10 Finland
Acute appendicitis with peritoneal abscess
16384.0
323.0
1597
*
5400A
ICD-9 Finland
Acute appendicitis, With generalised peritonitis[APPENDICITIS ACUTA CUM PERITONITIDE DIFFUSA]
+∞
319.8
305
*
P01AB01
ATC
metronidazole; oral, rectal
2.0
182.5
3415
21383
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
160.0
1113
4237
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
113.1
2745
17984
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
78.0
2080
13692
K36
ICD-10 Finland
Other appendicitis
694.1
70.2
69
*
K37
ICD-10 Finland
Unspecified appendicitis
39.1
70.1
89
23
54099
ICD-8 Finland
Acute appendicitis, Without mention of peritonitis
+∞
67.8
65
*
D88
ICPC
Appendicitis
304.6
59.4
60
*
5409X
ICD-9 Finland
Acute appendicitis, Without mention of peritonitis
+∞
54.2
52
*
R10.0
ICD-10 Finland
Acute abdomen
3.1
45.4
266
885
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.6
45.3
1397
9363
K35
ICD-10 Finland
Acute appendicitis
22.9
39.6
57
25
JN3AD
NOMESCO Finland
Abdominal CT examination
2.0
38.3
541
2838
JFB20
NOMESCO Finland
Ileocaecal resection
8.2
37.2
84
103
JAH01
NOMESCO Finland
Laparoscopy
2.3
34.8
335
1489
99850
ICD-8 Finland
Other complications of surgical procedures, Postoperative wound infection
7.2
33.6
83
117
JAH00
NOMESCO Finland
Laparotomy
2.8
33.0
217
780
J01DB01
ATC
cefalexin; oral
1.4
32.7
6201
56707
54009
ICD-8 Finland
NA
+∞
30.2
29
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.6
27.2
866
5794
J01MA12
ATC
levofloxacin; systemic
1.4
26.2
1234
8976
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
2.0
23.5
305
1547
54200
ICD-8 Finland
Other appendicitis, Appendicitis chronica
+∞
21.9
21
*
C18.11
ICD-10 Finland
Malignant tumor of the appendix invasive carcinoma
8.7
21.0
45
52
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
20.2
671
4523
54208
ICD-8 Finland
Other appendicitis
+∞
18.8
18
*
C18.19
ICD-10 Finland
Malignant tumor in appendix other or unspecified histology
10.0
17.8
35
35
JFB30
NOMESCO Finland
Right hemicolectomy
2.9
17.6
108
377
JEA10
NOMESCO Finland
Appendectomy with drainage
42.1
17.3
21
5
54199
ICD-8 Finland
Appendicitis, unqualified
+∞
16.7
16
*
J01MA02
ATC
ciprofloxacin; systemic
1.2
15.0
2522
21780
K65.0
ICD-10 Finland
Acute peritonitis
2.9
14.6
86
294
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
1.7
14.2
271
1580
N02BE01
ATC
paracetamol; systemic, rectal
1.2
13.7
6306
59783
ZXK00
NOMESCO Finland
Conversion from percutaneous endoscopic to open procedure
3.4
13.2
63
187
TPH04
NOMESCO Finland
Cathetrisation of vein
1.3
13.0
1276
10327
JN2AE
NOMESCO Finland
Ultrasound examination of lower part of abdomen without contrast
3.0
13.0
73
244
J01DA01
ATC
[U] cefalexin; systemic
1.2
12.8
4409
40541
UJF32
NOMESCO Finland
Coloscopy
1.2
12.1
1544
12888
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.2
11.7
2728
24179
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.5
10.9
419
2918
JAD30
NOMESCO Finland
Repair of incisional hernia using prosthetic material
2.2
10.6
108
501
JEW96
NOMESCO Finland
Other operation on appendix
+∞
10.4
10
*
5420A
ICD-9 Finland
Other appendicitis[APPENDICITIS CHRONICA]
+∞
10.4
10
*
8140/3-C18.1
ICD-O-3
Adenocarcinoma, NOS, of appendix
30.0
9.4
12
*
5410X
ICD-9 Finland
Appendicitis, unqualified[APPENDICITIS NUD]
+∞
9.4
9
*
54308
ICD-8 Finland
Other diseases of appendix, Alii definiti
+∞
9.4
9
*
5428X
ICD-9 Finland
Other appendicitis[APPENDICITIS ALIA DEFINITA]
+∞
9.4
9
*
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
4.3
9.1
32
75
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.2
9.0
1186
9915
N73.9
ICD-10 Finland
Female pelvic inflammatory disease, unspecified
2.3
8.8
76
328
WX110
NOMESCO Finland
Local anesthesy
1.1
8.6
4732
44468
C18.10
ICD-10 Finland
Malignant tumor of the appendix without histology
6.2
8.3
21
34
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
1.7
8.2
167
1000
JAD11
NOMESCO Finland
Laparoscopic repair of incisional hernia
2.4
8.1
64
266
6429
FHL
Other measure in this category
33.4
8.1
10
*
B01AB05
ATC
enoxaparin; parenteral
1.2
7.9
1781
15632
JAP01
NOMESCO Finland
Laparoscopic freeing of adhesions in the peritoneal cavity
2.1
7.8
85
411
6565
FHL
Sewerage the other way
80.2
7.4
8
*
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
2.0
7.4
89
450
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.2
7.3
898
7442
54090
ICD-8 Finland
Acute appendicitis, Phlegmonosa, peritonitide non indicata
+∞
7.3
7
*
K56.7
ICD-10 Finland
Ileus, unspecified
2.0
7.0
84
422
D06
ICPC
Abdominal pain localized other
1.4
7.0
391
2917
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
1.7
7.0
146
887
F20.9
ICD-10 Finland
Schizophrenia, unspecified
1.8
6.9
119
682
JAK00
NOMESCO Finland
Laparotomy and drainage of peritoneal cavity
5.3
6.7
19
36
D37.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Appendix
4.5
6.7
22
49
JFK10
NOMESCO Finland
Freeing of adhesions in intestinal obstruction
3.7
6.6
27
74
JAP00
NOMESCO Finland
Freeing of adhesions in the peritoneal cavity
2.2
6.6
60
270
8240/3-C18.2
ICD-O-3
Neuroendocrine tumor, NOS, of ascending colon
8.7
6.5
13
15
WX402
NOMESCO Finland
General anaesthesia
1.2
6.5
925
7784
JAD10
NOMESCO Finland
Repair of incisional hernia
2.5
6.5
49
200
S18
ICPC
Laceration/cut
1.1
6.3
2528
23098
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.2
6.3
891
7494
K50.0
ICD-10 Finland
Crohn disease of small intestine
2.0
6.3
77
395
R4110
NOMESCO Finland
Physiotherapy
1.2
6.3
1550
13684
54093
ICD-8 Finland
NA
+∞
6.2
6
*
K38.8
ICD-10 Finland
Other specified diseases of appendix
+∞
6.2
6
*
J01FF01
ATC
clindamycin; systemic
1.2
6.2
1646
14604
SPAT1153
SPAT
Removal of sutures
1.1
6.2
1866
16715
N05AH02
ATC
clozapine; systemic
1.8
6.1
105
603
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
2.0
6.1
75
385
8240/3-C18.1
ICD-O-3
Neuroendocrine tumor, NOS, of appendix
10.0
6.0
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
2775
22765
1.31
29.38
2.7
2.6
57.8
58.3
u/l
0.11
2569
21077
4328
37801
1.27
27.66
6.2
6.4
11.6
11.5
umol/l
0.18
4120
35903
2107
17448
1.27
19.08
2.5
2.4
—
—
—
0
0
3856
34179
1.22
18.60
4.1
4.0
—
—
—
0
0
1164
9020
1.33
17.25
8.3
7.4
104.5
104.5
mmol/l
0.02
1129
8825
4659
42788
1.18
13.44
5.2
4.8
6.8
6.7
mmol/l
1.28
4387
40060
4589
42299
1.17
12.08
10.1
9.3
4.4
4.1
e9/l
12.72
4011
36972
877
6860
1.31
11.98
2.6
2.6
33.7
47.9
u/l
1.16
764
5886
5021
46710
1.17
11.47
4.3
4.2
285.6
1470.7
e6/l
3.51
93
646
5975
56364
1.17
11.37
7.9
7.7
77.9
78.1
u/l
0.13
5672
53252
3048
27319
1.17
11.13
3.5
3.5
42.5
76.9
ng/l
1.11
2056
18332
1759
15136
1.20
10.18
2.7
2.6
7.1
5.1
e6/l
3.23
1528
13272
2456
21822
1.17
9.70
3.4
3.2
80.3
87.7
e6/l
0.07
1927
16788
2139
18798
1.18
9.66
4.3
4.0
89.5
90.0
%
0.50
2090
18323
818
6524
1.28
9.60
3.7
4.1
5.8
5.8
kpa
0.07
788
6329
678
5286
1.31
9.48
3.0
3.4
4.7
4.6
kpa
0.31
652
5109
3413
31240
1.15
8.83
5.2
5.0
35.0
35.6
g/l
6.68
3161
29101
808
6507
1.27
8.75
3.7
4.1
1.7
1.9
mmol/l
0.65
665
5263
776
6310
1.25
7.74
8.6
7.4
1.3
1.4
mmol/l
0.17
753
6062
1331
11433
1.19
7.68
1.8
1.8
—
—
—
0
0
3463
32000
1.13
7.35
7.0
6.2
1.2
1.2
mmol/l
0.05
3160
29105
1107
9443
1.20
6.88
6.4
6.2
1.0
1.0
mmol/l
0.71
1030
8833
2212
19925
1.15
6.86
3.3
3.2
0.5
0.4
e6/l
0.59
1699
14983
634
5118
1.26
6.75
1.6
1.7
—
—
—
0
0
1006
8562
1.20
6.40
2.6
2.8
9.1
8.6
umol/l
0.22
873
7483
5333
50815
1.12
6.31
3.2
3.1
49.8
49.3
u/l
0.15
5032
47655
2764
25378
1.13
6.26
3.9
3.7
75.7
87.4
e6/l
0.45
2047
18110
562
4563
1.25
5.73
11.4
9.5
0.7
0.7
%
0.24
557
4529
562
4577
1.24
5.58
11.3
9.4
1.4
1.4
%
0.07
557
4547
865
7367
1.19
5.47
4.3
4.1
18.2
26.5
ug/l
0.59
694
5983
7590
74066
1.14
5.45
15.9
14.1
32.3
23.6
mg/l
52.92
6284
58729
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
325
2488
1.32
5.32
3.2
3.2
0.3
0.3
u/ml
0.07
180
1431
3763
35408
1.11
5.22
7.8
6.9
1.2
1.2
mmol/l
0.19
3188
29962
558
4576
1.23
5.21
4.1
3.5
5.1
5.1
kpa
0.01
519
4219
7751
75856
1.14
4.88
17.8
15.9
139.6
139.7
mmol/l
3.28
7598
74031
288
2200
1.32
4.83
1.6
1.7
—
—
—
0
0
3661
34501
1.10
4.80
6.4
6.2
2.8
2.9
%
0.65
3446
32188
421
3387
1.25
4.71
4.0
4.4
24.1
24.1
mmol/l
0.08
385
3033
805
6913
1.18
4.65
9.6
8.4
122.1
122.0
g/l
0.03
774
6671
7770
76136
1.13
4.48
17.9
16.0
4.0
4.0
mmol/l
1.47
7600
74164
494
4071
1.23
4.45
1.7
1.7
—
—
—
0
0
398
3207
1.25
4.41
2.5
3.0
0.7
0.7
%
0.16
386
3068
407
3289
1.25
4.40
2.5
3.0
1.3
1.3
%
0.20
407
3269
185
1344
1.38
4.34
1.6
1.8
—
—
—
0
0
3773
35730
1.10
4.32
3.6
3.5
0.0
0.0
estimate
2.58
688
6309
515
4276
1.22
4.32
3.0
3.6
129.8
129.7
g/l
0.04
503
4179
3731
35370
1.09
4.11
4.8
4.7
0.0
0.0
estimate
1.34
712
6552
521
4354
1.21
4.10
4.1
3.5
1.8
1.7
mmol/l
0.15
395
3203
3723
35298
1.09
4.08
3.6
3.5
0.0
0.0
estimate
1.08
681
6401
392
3189
1.24
4.02
1.6
1.6
14.7
12.8
u/ml
0.08
12
91
768
6657
1.17
3.98
8.0
7.8
10.1
9.9
mmol/l
0.40
733
6364
265
2060
1.29
3.98
2.0
2.2
7407.3
4994.2
u/l
0.36
98
820
3701
35113
1.09
3.96
6.3
6.0
57.8
57.3
%
1.78
3480
32883
1768
16190
1.11
3.95
1.8
1.8
1.4
1.2
mg/l
1.69
1356
12476
383
3118
1.24
3.91
4.0
4.1
48.2
49.1
%
0.29
375
3084
3754
35652
1.09
3.91
6.5
6.2
27.4
27.9
%
1.55
3521
33243
295
2334
1.27
3.87
2.4
2.2
90.7
91.3
%
0.18
273
2179
890
7840
1.15
3.72
1.7
1.8
—
—
—
0
0
2927
27563
1.09
3.65
3.7
3.6
—
—
—
0
0
884
7796
1.15
3.64
1.7
1.7
—
—
—
0
0
945
8377
1.14
3.61
8.7
7.5
12.1
12.5
kpa
1.08
908
8004
945
8381
1.14
3.59
8.7
7.5
5.1
5.1
kpa
0.61
910
8001
2132
19800
1.10
3.59
3.1
3.0
1317.7
1413.4
ng/l
0.62
1830
16962
267
2108
1.27
3.59
2.7
2.5
193.8
190.7
%
0.23
254
2005
1348
12242
1.12
3.49
2.9
2.8
1.0
1.1
e6/l
0.35
743
7000
1261
11411
1.12
3.47
3.1
2.9
3.0
2.3
e6/l
1.67
660
6218
940
8354
1.14
3.47
8.7
7.5
1.0
1.0
mmol/l
0.11
739
6496
928
8241
1.14
3.46
4.2
4.4
241.1
241.4
u/l
0.02
885
7803
1054
9445
1.13
3.42
23.7
23.8
1.4
1.3
inr
1.00
159
1389
498
4224
1.19
3.39
1.5
1.5
—
—
—
0
0
1316
11967
1.12
3.33
3.4
3.4
0.8
0.8
mmol/l
0.42
1233
11214
5600
54290
1.08
3.26
4.1
4.0
12.3
11.8
mm/h
1.64
5188
50488
403
3370
1.20
3.23
3.5
3.6
25.1
25.2
mmol/l
0.11
389
3258
211
1647
1.29
3.15
3.8
4.2
2.8
2.5
mmol/l
0.95
142
1105
336
2768
1.22
3.14
1.1
1.1
1.0
10.2
u/ml
—
9
40
341
2817
1.22
3.11
4.4
3.7
24.9
24.8
mmol/l
0.24
313
2573
318
2618
1.22
3.01
3.7
3.5
2703.1
2246.1
u/ml
0.07
275
2256
118
852
1.39
3.00
2.9
3.2
3.1
13.0
nmol/l
0.90
112
828
59
370
1.60
2.99
1.2
1.3
246.3
437.9
u/l
1.49
54
338
3378
32216
1.08
2.93
10.7
9.6
0.0
0.0
e9/l
0.64
2745
26342
1245
11386
1.11
2.84
2.2
2.1
29.9
29.9
s
0.07
1209
11045
249
2013
1.24
2.82
1.5
1.5
5.6
14.0
iu/ml
—
9
43
7124
69899
1.09
2.75
14.5
13.0
82.5
82.2
ml/min/173m2
0.44
5924
58034
264
2154
1.23
2.75
2.7
2.7
3.8
3.6
g/l
0.92
249
2046
2621
24819
1.08
2.71
3.2
3.3
31.9
34.9
u/l
1.32
2490
23549
1411
13022
1.10
2.68
1.8
1.7
1181.5
1161.8
nmol/l
0.32
1085
9915
360
3039
1.19
2.66
2.0
2.0
—
—
—
0
0
769
6876
1.13
2.63
2.3
2.3
0.2
0.2
g/l
0.44
707
6401
38
221
1.72
2.60
2.6
2.9
—
—
—
0
0
38
221
1.72
2.60
2.6
2.9
—
—
—
0
0
2008
18847
1.08
2.59
4.0
3.9
0.0
0.0
estimate
2.77
649
6278
123
920
1.34
2.56
1.8
1.9
90.3
89.6
%
0.74
123
905
221
1785
1.24
2.56
2.5
2.4
107.6
112.5
ug/min
0.06
135
1097
189
1501
1.26
2.53
3.7
3.5
456.6
582.8
u/ml
0.19
176
1374
152
1175
1.30
2.52
2.8
2.7
8468.9
1718.8
u/ml
—
7
67
2335
22074
1.08
2.50
2.1
2.2
227.3
222.5
u/l
0.08
2212
20743
344
2912
1.19
2.49
2.4
1.9
2.3
2.3
ug/l
0.04
312
2572
449
3886
1.16
2.48
12.6
9.8
24.4
24.2
mmol/l
0.52
413
3632
197
1579
1.25
2.45
3.6
3.0
8.1
8.1
kpa
0.11
187
1453
1082
9906
1.10
2.43
2.7
2.6
22.1
23.2
%
1.82
939
8508
588
5199
1.14
2.42
4.4
4.0
96.8
92.9
ng/l
0.36
515
4522
304
2555
1.20
2.40
3.9
3.9
1.3
1.4
mmol/l
0.63
296
2513
1241
11461
1.10
2.33
2.7
2.6
12.8
13.3
umol/l
1.71
1161
10673
92
669
1.38
2.32
1.5
1.4
155705.9
106335.3
e6/l
0.27
60
455
1647
15406
1.08
2.31
4.1
3.9
1.0
1.0
kg/l
0.63
258
2308
2504
23796
1.07
2.30
3.4
3.5
2.4
2.4
mmol/l
0.01
2182
20904
213
1738
1.23
2.28
1.6
1.6
—
—
—
0
0
460
4020
1.15
2.26
11.9
10.3
—
—
—
0
0
298
2520
1.19
2.22
1.6
1.6
126.7
297.5
titre
1.65
15
102
15
67
2.24
2.17
1.2
1.1
—
—
—
0
0
86
628
1.37
2.15
1.6
1.7
—
—
—
0
0
86
628
1.37
2.15
1.6
1.7
—
—
—
0
0
86
628
1.37
2.15
1.6
1.7
—
—
—
0
0
2112
20000
1.07
2.13
2.7
2.6
3125.8
4272.9
umol/l
0.79
1840
17509
259
2172
1.20
2.13
4.4
4.2
3.8
3.9
mmol/l
1.18
231
2040
3057
29328
1.06
2.08
2.3
2.2
76.5
76.5
nmol/l
0.03
2770
26588
204
1678
1.22
2.06
1.6
1.7
—
—
—
0
0
15
69
2.18
2.04
2.6
2.4
0.3
0.5
u/field
0.70
15
69
8010
79199
1.09
2.04
10.8
10.3
27.1
27.3
u/l
0.30
7777
76583
141
1115
1.27
2.03
6.1
5.0
357.3
367.0
umol/l
0.33
121
957
440
3867
1.14
2.03
3.0
2.7
0.3
0.3
e6/l
0.20
426
3764
2393
22797
1.07
2.02
3.4
3.2
7.8
7.8
mmol/l
0.24
2070
19209
1635
15374
1.08
2.00
1.3
1.3
2.2
1.8
u/ml
0.45
445
4245
2358
22462
1.07
1.99
4.2
4.0
9.4
9.1
mg/mmol
0.15
1568
14506
224
1872
1.20
1.94
3.8
3.1
24.8
24.7
mmol/l
0.19
196
1626
1147
10648
1.09
1.94
2.7
2.6
2.4
2.3
g/l
1.53
1076
9910
183
1506
1.22
1.87
1.3
1.3
—
—
—
0
0
183
1506
1.22
1.87
1.3
1.3
—
—
—
0
0
947
8737
1.09
1.85
2.4
2.4
117.8
132.4
ug/g
0.85
760
6962
126
997
1.27
1.84
1.1
1.3
0.6
2.0
nmol/l
0.61
115
963
21
115
1.83
1.82
5.8
5.6
—
—
—
0
0
188
1559
1.21
1.79
5.8
5.7
459.3
2583.9
iu/ml
1.09
30
220
1890
17935
1.07
1.79
2.3
2.2
3.0
2.9
mg/l
0.16
1635
15375
3002
28899
1.06
1.77
2.0
2.0
95.4
95.3
pmol/l
0.06
1646
15438
681
6201
1.11
1.76
2.1
2.3
7.0
7.6
ug/l
0.42
601
5444
153
1247
1.23
1.74
1.7
1.8
—
—
—
0
0
796
7311
1.10
1.73
3.8
3.4
—
—
—
0
0
148
1204
1.23
1.72
3.7
3.0
0.9
0.8
nmol/l
0.43
120
893
49
339
1.45
1.71
1.1
1.1
168.6
182.6
iu/ml
0.21
49
339
33
210
1.57
1.70
1.0
1.2
—
—
—
0
0
98
760
1.29
1.70
1.6
1.7
—
—
—
0
0
259
2225
1.17
1.68
1.8
1.8
—
—
—
0
0
2234
21366
1.06
1.64
3.4
3.3
460.6
423.6
mg/l
0.13
1472
13734
865
8004
1.09
1.61
3.1
2.5
1.8
1.8
%
0.01
769
7095
147
1205
1.22
1.61
3.2
3.4
1.5
1.5
%
0.09
112
926
184
1542
1.20
1.61
3.3
2.6
16.3
16.3
%
0.03
100
810
125
1007
1.24
1.61
1.1
1.3
0.3
0.3
nmol/l
—
5
63
101
794
1.28
1.59
9.8
14.3
7.2
7.4
mmol/l
0.33
77
669
180
1509
1.20
1.57
3.1
3.2
1.6
1.6
mmol/l
0.11
175
1474
1698
16127
1.06
1.57
1.6
1.5
19.8
20.1
nmol/l
0.34
1469
13926
317
2783
1.14
1.56
1.9
1.8
—
—
—
0
0
288
2514
1.15
1.54
2.6
2.3
455.2
602.9
ug/l
0.62
270
2361
8335
82705
1.09
1.50
22.8
20.5
4.5
4.5
e12/l
5.00
8109
80493
48
341
1.41
1.49
4.6
3.4
—
—
—
0
0
8328
82636
1.09
1.48
22.9
20.5
250.4
250.3
e9/l
0.05
8137
80644
8336
82726
1.08
1.46
23.0
20.6
135.5
136.5
g/l
7.35
8236
81627
939
8764
1.08
1.44
4.4
4.3
31.6
31.9
%
0.38
671
6095
8335
82721
1.08
1.44
22.9
20.5
6.8
6.7
e9/l
4.91
8106
80494
12
59
2.04
1.43
1.1
1.3
143.8
125.6
ug/l
—
6
34
113
917
1.24
1.40
1.1
1.1
—
—
—
0
0
15
263
0.57
1.39
1.1
1.1
—
—
—
0
0
53
390
1.36
1.37
1.6
2.0
—
—
—
0
0
281
2473
1.14
1.37
2.6
2.7
—
—
—
0
0
503
4582
1.10
1.36
7.0
7.0
24.6
24.5
mmol/l
0.15
471
4272
58
435
1.34
1.33
11.0
12.6
0.6
0.6
mmol/l
0.18
51
400
51
376
1.36
1.31
2.0
1.6
2.0
3.1
u/field
0.71
37
267
84
665
1.27
1.31
1.5
1.5
31.8
29.3
%
0.26
53
397
119
981
1.22
1.29
1.6
1.6
—
—
—
0
0
187
1606
1.17
1.29
1.4
1.4
—
—
—
0
0
85
676
1.26
1.28
1.5
1.4
6.8
6.3
mmol/l
0.55
77
630
36
252
1.43
1.25
1.7
1.9
—
—
—
0
0
361
3248
1.12
1.25
2.0
1.7
1.6
1.5
g/l
0.37
311
2774
54
406
1.33
1.24
3.8
3.6
30.7
27.1
mu/l
0.30
47
385
52
389
1.34
1.23
1.6
2.0
—
—
—
0
0
52
389
1.34
1.23
1.6
2.0
—
—
—
0
0
52
389
1.34
1.23
1.6
2.0
—
—
—
0
0
5
19
2.63
1.21
7.2
11.1
—
—
—
0
0
53
401
1.32
1.18
1.7
1.6
—
—
—
0
0
249
2204
1.13
1.16
3.6
3.3
45.3
82.6
mg/l
0.79
199
1782
87
704
1.24
1.15
1.6
1.8
—
—
—
0
0
146
1243
1.18
1.15
1.2
1.2
—
—
—
0
0
5
20
2.50
1.15
1.6
1.1
—
—
—
0
0
53
403
1.32
1.15
1.7
1.6
—
—
—
0
0
30
427
0.70
1.14
1.3
1.5
1.1
1.2
nmol/l
0.39
25
325
72
571
1.26
1.14
1.7
1.6
—
—
—
0
0
636
5913
1.08
1.13
2.6
2.5
66.3
66.5
g/l
0.31
580
5422
166
1919
0.86
1.12
1.2
1.2
—
—
—
0
0
248
2203
1.13
1.10
3.6
3.3
30.7
51.2
mg/l
2.38
199
1785
105
872
1.21
1.10
2.1
2.3
4.1
4.1
mmol/l
0.33
105
860
105
872
1.21
1.10
2.1
2.3
105.1
105.4
mmol/l
0.29
105
860
213
1874
1.14
1.10
1.3
1.3
2.8
7.1
u/ml
2.65
33
302
69
549
1.26
1.08
1.6
1.7
—
—
—
0
0
6232
61506
1.04
1.06
19.0
17.0
13.7
13.7
%
0.05
6098
60223
179
1561
1.15
1.06
1.7
1.5
—
—
—
0
0
98
814
1.21
1.04
1.7
1.6
—
—
—
0
0
23
336
0.68
1.03
1.1
1.1
1388.2
1536.4
miu/ml
0.33
23
336
33
449
0.73
0.99
3.0
2.8
29.2
38.7
%
—
8
153
208
1846
1.13
0.97
1.3
1.3
4.9
5.0
u/ml
0.01
24
181
240
2150
1.12
0.96
3.6
3.2
2.5
3.6
ratio
0.49
15
174
3194
31175
1.04
0.95
2.9
2.8
140.0
136.1
ug/l
0.33
2973
29015
328
2989
1.10
0.95
4.5
5.3
1.7
1.7
%
0.09
306
2805
182
2061
0.88
0.95
1.3
1.3
—
—
—
0
0
30
216
1.39
0.95
1.2
1.3
—
—
—
0
0
227
2030
1.12
0.94
1.3
1.3
32.6
38.7
u/ml
0.11
15
128
1581
15215
1.05
0.94
1.7
1.7
25729680.6
32401394.1
pmol/l
0.22
1337
12799
509
4734
1.08
0.94
1.2
1.2
130.5
145.7
iu/ml
0.41
205
1827
106
899
1.18
0.92
1.7
1.6
56.9
58.5
%
0.16
67
562
243
2698
0.90
0.92
1.9
1.9
—
—
—
0
0
78
643
1.21
0.92
1.3
1.2
—
—
—
0
0
33
243
1.36
0.92
2.2
3.2
—
—
—
0
0
10
55
1.82
0.92
1.0
1.1
—
—
—
0
0
132
1141
1.16
0.91
1.1
1.1
—
—
—
0
0
7148
70830
1.04
0.90
3.9
3.9
1.4
1.3
mmol/l
4.19
6599
65494
152
1331
1.14
0.89
1.8
1.7
—
—
—
0
0
224
2011
1.12
0.88
3.4
3.0
1.8
1.5
mg/l
3.18
208
1855
1429
13748
1.05
0.87
1.5
1.5
2.4
2.5
g/l
1.15
869
8639
228
2052
1.11
0.87
1.2
1.3
—
—
—
0
0
171
1513
1.13
0.86
2.9
1.9
0.8
0.8
nmol/l
0.89
137
1277
237
2138
1.11
0.86
1.9
1.6
0.2
0.2
g/l
0.16
221
2029
39
504
0.77
0.85
1.1
1.0
45.3
42.7
ng/l
0.15
29
349
84
704
1.19
0.85
3.1
3.1
—
—
—
0
0
1307
12559
1.05
0.84
1.5
1.5
—
—
—
0
0
1461
14077
1.05
0.84
3.8
3.7
374.6
552.7
ng/l
1.06
1116
10790
40
309
1.30
0.83
2.5
2.3
—
—
—
0
0
36
274
1.32
0.83
1.8
1.5
63.7
64.7
%
0.07
26
229
186
1660
1.12
0.83
2.9
2.2
129.3
130.0
g/l
0.13
138
1183
4835
47619
1.03
0.83
2.9
2.9
—
—
—
0
0
39
501
0.78
0.82
1.1
1.0
704.7
732.2
ng/l
0.16
31
340
11
65
1.69
0.82
1.5
1.0
20.3
14.7
iu/ml
—
6
24
21
146
1.44
0.82
3.8
2.0
7.2
7.7
mmol/l
0.44
11
84
39
499
0.78
0.80
1.1
1.0
327.2
318.2
ng/l
0.09
30
350
97
829
1.17
0.80
1.2
1.1
95.1
97.0
%
0.32
92
774
157
1390
1.13
0.80
1.6
1.5
109.1
115.5
u/ml
0.45
45
312
29
215
1.35
0.80
1.3
1.2
42.1
39.2
g/l
0.47
12
117
162
1438
1.13
0.80
1.8
1.6
—
—
—
0
0
43
338
1.27
0.79
1.2
1.6
7.8
12.5
nmol/l
0.22
34
274
84
710
1.18
0.79
1.4
1.4
—
—
—
0
0
170
1514
1.13
0.79
1.2
1.3
51.4
41.3
u/ml
0.25
19
150
173
1543
1.12
0.79
3.9
3.4
30.1
26.6
mg/l
0.58
109
970
20
282
0.71
0.79
1.3
1.8
2643.0
13265.8
u/ml
—
6
40
8
48
1.67
0.78
6.0
4.0
—
—
—
0
0
235
2135
1.10
0.77
1.5
1.4
290.9
273.3
ug/g
0.64
141
1257
259
2366
1.10
0.76
1.7
1.6
290.8
296.9
mu/l
0.15
239
2158
6
34
1.77
0.76
1.2
1.1
—
—
—
0
0
15
99
1.52
0.75
1.3
1.9
—
—
—
0
0
594
5610
1.06
0.75
2.8
2.6
10.3
10.6
g/l
1.02
530
5143
11
67
1.64
0.75
1.1
1.1
—
—
—
0
0
13
83
1.57
0.74
1.0
1.1
—
—
—
0
0
144
1276
1.13
0.74
1.5
1.5
—
—
—
0
0
284
2610
1.09
0.74
2.4
2.3
3.1
3.1
g/l
0.13
226
2049
115
1005
1.15
0.73
1.7
1.7
—
—
—
0
0
5624
55583
1.03
0.73
4.0
3.9
14.7
14.7
pmol/l
0.38
5131
50878
195
1761
1.11
0.73
1.8
1.6
13525.2
13184.1
e6/l
0.04
150
1257
7
38
1.84
0.73
9.3
5.5
—
—
—
0
0
230
2097
1.10
0.72
2.6
2.2
0.0
0.0
g/l
0.61
211
1928
235
2145
1.10
0.72
2.6
2.1
37.3
37.8
g/l
0.52
205
1867
242
2213
1.10
0.71
1.9
1.6
1.2
1.2
g/l
0.37
228
2102
13
84
1.55
0.71
1.6
1.5
—
—
—
0
0
11
68
1.62
0.71
1.0
1.0
0.1
0.1
u/ml
—
5
44
12
76
1.58
0.71
2.0
1.9
—
—
—
0
0
56
462
1.21
0.70
1.7
1.5
—
—
—
0
0
213
1938
1.10
0.70
2.7
2.2
0.0
0.0
g/l
0.79
194
1774
38
300
1.27
0.70
1.7
2.2
—
—
—
0
0
20
143
1.40
0.70
1.2
1.3
0.8
112.8
mg/l
1.26
14
108
683
6497
1.06
0.69
1.8
1.9
—
—
—
0
0
257
2362
1.09
0.69
2.8
2.3
0.7
0.9
g/l
0.61
221
2047
42
520
0.81
0.69
1.7
1.7
—
—
—
0
0
340
3162
1.08
0.69
1.8
2.0
38.6
39.2
u/l
0.22
300
2815
105
918
1.15
0.68
1.3
1.3
293.2
289.7
pmol/l
0.04
82
691
136
1210
1.13
0.68
1.1
1.1
114.0
8576.0
iu/ml
0.54
22
278
30
231
1.30
0.67
1.3
1.3
109.7
110.2
%
0.03
22
206
17
119
1.43
0.66
2.0
1.5
9.5
9.5
%
—
8
65
95
1089
0.87
0.66
1.1
1.1
—
—
—
0
0
32
407
0.79
0.66
4.3
6.0
41.0
8403.5
u/ml
—
5
84
5
28
1.79
0.66
1.0
1.0
—
—
—
0
0
125
1109
1.13
0.66
1.1
1.1
122.1
117.2
%
1.07
118
1001
66
558
1.18
0.66
1.2
1.2
38.0
46.0
u/ml
—
6
43
115
1015
1.13
0.66
1.6
1.5
—
—
—
0
0
229
2100
1.09
0.65
1.3
1.3
8.8
10.1
u/l
0.70
183
1720
134
1195
1.12
0.65
1.1
1.3
62.0
36.3
u/l
0.48
118
1036
209
1910
1.10
0.65
2.7
2.2
0.0
0.0
g/l
0.00
194
1769
35
277
1.26
0.65
1.2
1.2
—
—
—
0
0
19
137
1.39
0.64
1.5
2.0
19.1
17.4
umol/l
0.18
19
137
32
251
1.28
0.63
1.3
1.2
0.3
0.3
g/l
0.03
23
203
129
1151
1.12
0.63
1.2
1.2
3.9
3.6
u/ml
0.06
40
380
65
552
1.18
0.62
1.9
1.9
3.0
1.7
u/field
0.92
35
225
6851
67985
1.03
0.62
5.8
5.6
40.0
39.7
mmol/mol
1.39
6367
63327
216
1982
1.09
0.62
1.5
1.4
—
—
—
0
0
59
697
0.85
0.62
1.4
1.4
1.3
1.4
promille
0.22
46
535
37
297
1.25
0.62
1.7
2.2
—
—
—
0
0
37
297
1.25
0.62
1.7
2.2
—
—
—
0
0
35
280
1.25
0.60
1.1
1.2
—
—
—
0
0
17
122
1.39
0.60
1.3
1.3
—
—
—
0
0
87
760
1.15
0.59
1.2
1.2
—
—
—
0
0
23
174
1.32
0.59
1.1
1.1
—
—
—
0
0
120
1342
0.89
0.59
1.6
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
1.1
—
0
14
168
1529
1.10
0.58
1.2
1.2
20.2
25.1
u/ml
—
6
19
208
1914
1.09
0.58
1.1
1.1
7.2
6.9
u/ml
0.03
29
259
315
2949
1.07
0.57
4.7
5.4
0.9
0.9
%
0.98
296
2770
6753
67037
1.03
0.56
4.7
4.5
2.9
2.1
mu/l
0.74
6220
61661
291
2718
1.07
0.56
1.7
1.7
3.3
3.7
mg/l
0.36
215
1896
1541
15825
0.97
0.55
2.9
2.9
0.8
0.8
ug/l
0.10
1001
10193
109
973
1.12
0.55
1.5
1.4
—
—
—
0
0
52
440
1.18
0.54
1.3
1.5
5.2
6.2
u/l
1.10
39
382
23
177
1.30
0.54
1.1
1.1
—
—
—
0
0
475
4514
1.06
0.54
1.4
1.3
237.9
230.7
u/ml
0.05
445
4178
35
285
1.23
0.53
1.1
1.1
—
—
—
0
0
29
231
1.26
0.53
1.9
1.5
2.2
2.7
%
0.17
23
199
187
1721
1.09
0.53
1.9
1.8
3.8
9.4
iu/l
0.60
67
635
84
740
1.14
0.53
1.4
1.5
—
—
—
0
0
64
553
1.16
0.53
2.0
2.7
616.4
705.8
e6/l
0.51
32
229
107
958
1.12
0.52
1.4
1.5
—
—
—
0
0
25
196
1.28
0.52
1.2
1.2
937.3
409.3
ug/l
0.27
16
106
6
97
0.62
0.52
1.0
1.0
—
—
—
0
0
113
1016
1.11
0.52
5.6
6.7
11.2
11.5
mg/l
0.26
106
937
37
305
1.21
0.51
1.1
1.1
—
—
—
0
0
71
810
0.88
0.51
1.0
1.1
3.2
0.3
u/ml
0.50
17
179
26
206
1.26
0.50
1.1
1.1
84.3
87.0
%
0.18
15
107
748
7202
1.04
0.50
1.9
2.0
—
—
—
0
0
68
593
1.15
0.50
2.4
2.3
654.5
651.3
ml
0.02
44
405
43
361
1.19
0.50
1.2
1.2
—
—
—
0
0
62
713
0.87
0.50
3.0
3.7
—
—
—
0
0
42
352
1.19
0.50
1.3
1.5
3.7
3.7
%
—
7
84
108
972
1.11
0.49
1.7
1.5
32.8
32.9
g/l
0.04
100
881
1293
12586
1.03
0.48
1.3
1.3
23.1
33.3
iu/ml
3.16
382
3964
7
46
1.52
0.48
1.7
3.2
—
—
—
0
0
227
2118
1.07
0.48
1.2
1.3
222.4
215.7
miu/ml
0.10
97
955
122
1108
1.10
0.48
1.5
1.4
—
—
—
0
0
56
484
1.16
0.47
1.1
1.1
—
—
—
0
0
604
5799
1.04
0.47
4.3
4.0
1.2
1.2
mmol/l
0.08
551
5093
7
48
1.46
0.46
1.1
1.2
—
—
—
0
0
39
462
0.84
0.46
1.3
1.1
—
—
—
0
0
14
187
0.75
0.45
1.0
1.0
—
—
—
0
0
87
970
0.90
0.45
1.1
1.1
5.9
3.4
u/ml
0.53
34
362
301
2844
1.06
0.45
1.3
1.3
1.5
0.9
u/ml
0.25
26
265
211
2258
0.93
0.45
1.5
1.5
—
—
—
0
0
86
770
1.12
0.44
1.2
1.4
—
31.2
—
0
8
81
905
0.89
0.44
1.1
1.1
3.1
3.5
u/ml
0.10
34
348
68
601
1.13
0.43
1.1
1.0
276.2
283.4
mg/l
0.38
57
548
126
1375
0.92
0.43
1.1
1.1
1.2
1.4
u/ml
0.13
55
523
55
479
1.15
0.43
1.2
1.2
—
—
—
0
0
27
220
1.23
0.43
1.3
1.3
3.0
3.3
mmol/l
0.19
27
201
104
944
1.10
0.43
1.4
1.5
—
—
—
0
0
5
31
1.61
0.43
1.2
1.2
—
—
—
0
0
295
2791
1.06
0.43
2.4
2.2
7.4
7.4
g/l
0.23
232
2087
251
2366
1.06
0.41
1.7
1.7
—
—
—
0
0
10
70
1.43
0.41
2.2
2.0
—
—
—
0
0
218
2046
1.07
0.41
1.1
1.2
—
—
—
0
0
352
3352
1.05
0.41
3.7
3.4
45.9
50.0
u/ml
0.13
344
3228
0
16
0.00
0.41
0.0
2.4
—
—
—
0
0
32
380
0.84
0.40
1.5
1.5
8.0
7.8
mmol/l
0.11
17
230
13
172
0.76
0.40
1.1
1.4
—
—
—
0
0
165
1535
1.08
0.40
1.2
1.2
1.4
3.6
u/ml
0.90
14
111
294
2789
1.06
0.40
2.4
2.2
—
—
—
0
0
74
663
1.12
0.39
1.3
1.6
—
—
—
0
0
13
97
1.34
0.39
1.5
1.4
10.3
336716.5
nmol/l
0.72
13
79
37
432
0.86
0.39
1.1
1.1
3.4
10.8
nmol/l
—
8
85
227
2139
1.06
0.39
1.3
1.2
203.5
115.1
titre
0.56
17
191
100
1095
0.91
0.39
1.1
1.1
2.4
13.7
au/ml
—
7
60
11
148
0.74
0.38
1.2
1.1
0.5
0.7
umol/24h
—
5
74
16
124
1.29
0.38
1.8
1.7
151.7
149.4
ng/l
0.01
16
124
13
98
1.33
0.37
2.6
3.6
47.0
39.9
umol/l
0.58
13
79
20
161
1.24
0.37
1.2
1.2
—
—
—
0
0
20
161
1.24
0.37
1.1
1.1
—
—
—
0
0
13
169
0.77
0.36
1.1
1.1
—
—
—
0
0
14
180
0.78
0.36
1.2
1.1
—
—
—
0
0
1296
12685
1.03
0.36
3.2
3.1
2.5
2.4
mmol/l
0.73
1109
11080
147
1576
0.93
0.36
1.2
1.3
3.8
3.8
mmol/l
0.04
142
1471
215
2031
1.06
0.35
1.1
1.2
—
—
—
0
0
273
2597
1.05
0.35
2.5
2.2
9.9
10.3
g/l
0.99
230
2204
60
536
1.12
0.35
1.2
1.2
—
—
—
0
0
7529
74993
1.02
0.34
4.8
4.8
2.8
2.8
mmol/l
1.67
6992
69666
60
537
1.12
0.34
1.2
1.2
—
—
—
0
0
31
362
0.86
0.34
1.9
2.2
77.4
163.4
ug/min
—
7
87
103
1117
0.92
0.34
1.1
1.1
2.4
1.7
u/ml
0.23
26
256
122
1132
1.08
0.34
1.2
1.2
3.8
4.4
u/ml
0.18
48
501
84
767
1.10
0.33
2.1
1.5
34.3
28.4
iu/ml
—
6
37
292
2788
1.05
0.33
2.4
2.2
3.7
3.8
g/l
1.19
221
1998
59
657
0.90
0.33
1.4
1.3
73.7
111.4
pmol/l
0.35
19
208
15
118
1.27
0.33
1.0
1.1
94.2
79.9
ug/l
—
10
97
102
941
1.08
0.33
1.4
1.5
—
—
—
0
0
96
1042
0.92
0.33
1.1
1.3
7.6
7.3
mmol/l
0.35
64
779
60
539
1.11
0.33
1.2
1.1
—
—
—
0
0
60
539
1.11
0.33
1.2
1.1
—
—
—
0
0
157
1670
0.94
0.32
6.7
7.3
105.6
105.2
mmol/l
0.57
145
1504
60
540
1.11
0.32
1.2
1.1
—
—
—
0
0
10
132
0.76
0.32
1.2
1.5
—
—
—
0
0
17
137
1.24
0.32
1.1
1.3
—
—
—
0
0
14
176
0.80
0.32
1.2
1.1
—
—
—
0
0
12
92
1.30
0.31
1.5
1.2
—
—
—
0
0
57
512
1.11
0.31
1.2
1.2
—
—
—
0
0
122
1137
1.07
0.31
1.6
1.5
—
—
—
0
0
427
4422
0.96
0.31
3.9
3.4
4.4
4.5
pmol/l
0.25
386
3938
15
186
0.81
0.30
1.2
1.1
—
—
—
0
0
23
193
1.19
0.30
1.4
1.3
42.5
37.7
%
0.19
13
126
36
315
1.14
0.30
1.3
1.5
—
—
—
0
0
35
306
1.14
0.29
1.5
2.5
—
—
—
0
0
214
2246
0.95
0.29
1.4
1.4
—
—
—
0
0
8
107
0.75
0.29
1.1
1.2
—
—
—
0
0
71
650
1.09
0.28
1.0
1.1
—
—
—
0
0
525
5096
1.03
0.28
2.3
2.4
20.7
25.2
au/ml
0.33
28
301
53
478
1.11
0.28
1.3
1.2
—
—
—
0
0
20
167
1.20
0.28
1.1
1.2
207.6
314.6
pmol/l
1.91
14
121
12
151
0.79
0.28
1.2
1.1
—
—
—
0
0
615
6314
0.97
0.27
2.4
2.2
11.9
12.8
nmol/l
2.01
555
5611
37
327
1.13
0.27
5.8
5.3
5478.0
766.4
mg/l
0.40
28
238
21
177
1.19
0.27
1.0
1.1
—
—
—
0
0
27
233
1.16
0.27
1.8
2.0
—
—
—
0
0
111
1185
0.94
0.27
1.1
1.1
2.1
1.1
u/ml
0.27
50
475
16
131
1.22
0.27
1.8
1.2
93.8
106.9
%
0.90
16
123
40
356
1.12
0.27
1.2
1.1
—
—
—
0
0
18
215
0.84
0.27
1.6
1.5
9.1
8.9
ug/l
0.14
18
215
39
347
1.12
0.26
1.2
1.2
—
—
—
0
0
41
366
1.12
0.26
1.3
1.5
—
—
—
0
0
41
366
1.12
0.26
1.3
1.5
—
—
—
0
0
22
187
1.18
0.26
1.1
1.5
555.7
415.6
mu/l
0.56
22
178
13
104
1.25
0.26
1.0
1.1
0.1
1.6
u/ml
—
7
75
675
6589
1.03
0.26
2.2
2.3
386.3
368.5
nmol/l
0.72
633
6058
159
1508
1.06
0.26
1.2
1.2
—
—
—
0
0
24
206
1.17
0.26
1.2
1.1
—
—
—
0
0
116
1234
0.94
0.26
1.1
1.1
3.4
5.1
u/ml
0.67
55
599
2168
21937
0.98
0.25
4.0
4.1
21.8
21.9
%
0.07
1021
10269
5
75
0.67
0.25
1.2
1.2
1.4
1.7
umol/24h
—
5
75
16
132
1.21
0.25
1.8
3.0
14.6
14.9
ml/dl
0.19
16
124
239
2293
1.04
0.25
1.4
1.3
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
24
207
1.16
0.25
1.3
1.2
100.0
102.9
%
0.16
24
188
53
483
1.10
0.24
1.3
1.2
—
—
—
0
0
596
6104
0.97
0.24
2.9
2.6
63.9
67.5
ml/min/173m2
1.14
253
2375
477
4645
1.03
0.23
1.2
1.3
50.8
53.2
au/ml
0.06
20
211
15
179
0.84
0.23
1.6
1.2
—
—
—
0
0
22
190
1.16
0.23
1.1
1.5
72.2
72.6
%
0.04
22
181
1213
11944
1.02
0.23
1.3
1.3
10.3
12.0
u/ml
0.39
469
4761
5
39
1.28
0.23
1.0
1.0
—
—
—
0
0
29
327
0.89
0.22
2.1
1.6
—
1487465.6
iu/ml
—
0
16
7178
71553
1.01
0.22
4.5
4.4
6.0
5.9
mmol/l
1.87
6593
65794
7
92
0.76
0.22
1.0
1.0
—
—
—
0
0
7
94
0.74
0.22
2.7
2.0
—
—
—
0
0
41
452
0.91
0.22
1.1
1.1
5.9
10.3
iu/ml
1.06
12
111
5
41
1.22
0.22
1.0
1.0
—
—
—
0
0
147
1401
1.05
0.22
1.2
1.3
272.6
276.2
u/ml
0.05
97
894
14
116
1.21
0.22
2.3
1.9
—
—
—
0
0
152
1589
0.96
0.20
1.3
1.4
265.0
3533.4
e6/l
0.80
120
1284
10
80
1.25
0.20
1.2
1.1
—
—
—
0
0
43
470
0.91
0.20
1.3
1.4
—
—
—
0
0
56
518
1.08
0.20
1.9
2.6
496.3
490.5
e6/l
0.02
47
434
29
324
0.89
0.20
2.0
1.9
—
—
—
0
0
54
499
1.08
0.20
1.1
1.1
—
—
—
0
0
46
422
1.09
0.20
1.2
1.4
52.0
394.7
titre
—
5
34
23
202
1.14
0.20
1.3
1.1
81.5
86.9
%
0.26
14
108
9
114
0.79
0.20
1.1
1.1
—
—
—
0
0
53
490
1.08
0.19
1.6
1.6
17.4
24.0
u/ml
1.14
11
109
6
50
1.20
0.19
1.3
1.2
—
—
—
0
0
6
50
1.20
0.19
1.0
1.0
—
—
—
0
0
241
2332
1.03
0.19
1.6
1.6
0.1
10.9
iu/ml
0.91
42
512
14
118
1.19
0.19
1.6
1.4
—
—
—
0
0
33
364
0.91
0.19
1.1
1.1
1.2
18.6
u/ml
—
5
32
44
478
0.92
0.19
1.3
1.7
—
—
—
0
0
37
337
1.10
0.19
1.7
1.8
76.1
146.3
umol/l
2.37
14
171
16
185
0.86
0.18
1.1
1.1
—
—
—
0
0
17
147
1.16
0.18
3.4
2.4
—
—
—
0
0
43
396
1.09
0.18
1.1
1.1
1.2
1.1
u/l
0.48
19
188
38
348
1.09
0.17
1.4
1.1
—
—
—
0
0
52
558
0.93
0.17
1.8
2.1
12.9
14.7
%
0.32
19
253
24
268
0.90
0.17
1.2
1.4
—
—
—
0
0
153
1589
0.96
0.17
1.3
1.4
18.5
28.9
e6/l
0.46
114
1215
12
101
1.19
0.16
12.2
11.9
6.3
5.4
mmol/l
0.25
12
101
77
813
0.95
0.16
1.2
1.2
52.6
63.5
u/l
1.58
50
539
65
690
0.94
0.16
1.0
1.1
—
—
—
0
0
90
856
1.05
0.16
1.6
1.5
5025.6
2257.3
e6/l
0.39
64
626
56
597
0.94
0.16
1.3
1.1
—
34.9
—
0
6
148
1535
0.96
0.15
1.5
1.4
—
—
—
0
0
293
3004
0.97
0.15
1.8
1.8
—
—
—
0
0
160
1656
0.97
0.15
2.3
2.9
34.3
35.4
umol/l
0.20
139
1410
9
78
1.15
0.15
1.1
1.1
—
—
—
0
0
98
937
1.05
0.15
1.4
1.5
—
—
—
0
0
230
2364
0.97
0.15
1.5
1.5
—
—
—
0
0
26
286
0.91
0.15
1.1
1.1
—
—
—
0
0
349
3566
0.98
0.15
1.3
1.4
—
—
—
0
0
7337
73216
1.01
0.14
4.3
4.3
1.4
1.4
mmol/l
2.92
6814
68095
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
15
131
1.15
0.14
1.5
1.2
91.5
72.6
%
—
6
42
14
160
0.87
0.14
1.3
1.6
0.3
0.4
ug/l
—
8
104
41
382
1.07
0.14
1.1
1.1
12.6
27.4
u/l
3.64
31
295
719
7289
0.99
0.14
1.7
1.8
—
—
—
0
0
53
499
1.06
0.14
2.0
2.6
0.2
0.2
e9/l
0.81
47
429
41
383
1.07
0.13
1.1
1.1
79.3
90.6
u/l
0.82
32
307
54
510
1.06
0.13
1.3
1.4
—
—
—
0
0
45
479
0.94
0.13
1.3
1.4
—
—
—
0
0
12
138
0.87
0.13
1.0
1.2
—
—
—
0
0
10
117
0.85
0.13
1.2
1.1
—
—
—
0
0
50
530
0.94
0.13
1.9
2.1
—
—
—
0
0
167
1623
1.03
0.12
2.0
1.5
—
—
—
0
0
59
560
1.05
0.12
1.1
1.1
437.9
274.8
mg/l
0.92
52
482
349
3425
1.02
0.12
1.4
1.3
29.0
31.3
iu/l
0.66
298
2951
320
3261
0.98
0.12
1.2
1.1
267.7
229.4
titre
0.15
15
87
55
522
1.05
0.12
1.5
1.3
1.5
1.7
u/ml
0.06
24
237
88
846
1.04
0.12
1.4
1.5
—
—
—
0
0
172
1766
0.97
0.11
1.2
1.3
—
—
—
0
0
90
935
0.96
0.11
1.2
1.3
75.3
64.6
u/ml
—
7
65
39
366
1.07
0.11
3.4
3.9
—
—
—
0
0
874
8831
0.99
0.11
7.4
6.9
—
—
—
0
0
63
601
1.05
0.11
1.2
1.2
185.0
189.4
titre
0.01
12
110
70
670
1.05
0.11
1.3
1.4
9.8
3.4
ug/l
0.52
59
574
17
153
1.11
0.11
1.0
1.1
77.7
60.0
u/ml
0.33
17
146
95
984
0.97
0.11
1.1
1.1
—
—
—
0
0
113
1166
0.97
0.10
1.3
1.3
—
—
—
0
0
50
526
0.95
0.10
1.3
1.2
—
—
—
0
0
7384
73728
1.01
0.10
4.4
4.3
4.7
4.7
mmol/l
1.45
6899
68920
60
627
0.96
0.10
3.8
3.8
29.6
41.8
u/ml
0.95
60
621
87
840
1.04
0.10
2.4
2.0
36.9
23.3
mg/l
0.98
28
216
187
1829
1.02
0.10
2.0
1.9
198.3
201.0
pmol/l
0.12
178
1734
1025
10332
0.99
0.09
1.4
1.5
—
—
—
0
0
5
47
1.06
0.09
1.0
1.3
—
—
—
0
0
176
1798
0.98
0.09
1.3
1.3
588.2
528.9
mg/l
0.60
169
1707
374
3792
0.99
0.09
1.9
1.9
—
—
—
0
0
35
370
0.95
0.09
1.4
1.6
—
—
—
0
0
11
97
1.13
0.09
1.2
1.1
—
—
—
0
0
34
321
1.06
0.09
2.1
1.7
—
—
—
0
0
6
54
1.11
0.09
1.0
1.0
—
—
—
0
0
97
942
1.03
0.08
1.4
1.5
—
—
—
0
0
5
64
0.78
0.08
1.2
1.5
37.0
41.9
umol/l
—
5
64
7
65
1.08
0.08
1.0
1.1
—
—
—
0
0
350
3545
0.99
0.08
1.0
1.1
—
—
—
0
0
6
70
0.86
0.07
1.2
1.1
—
—
—
0
0
60
579
1.04
0.07
1.1
1.1
65.1
42.4
mg/l
1.04
54
477
102
1046
0.97
0.07
1.1
1.1
1.5
1.5
g/l
1.15
89
957
97
945
1.03
0.07
1.4
1.5
—
—
—
0
0
113
1104
1.02
0.07
1.3
1.4
31.6
29.0
u/l
0.35
97
906
7
82
0.85
0.07
1.3
1.4
68.3
76.9
%
—
7
68
7
83
0.84
0.07
1.0
1.1
—
—
—
0
0
9
85
1.06
0.07
1.2
1.1
—
—
—
0
0
18
167
1.08
0.06
4.8
6.5
70.0
70.9
%
0.04
12
135
75
770
0.97
0.06
1.1
1.1
—
12.6
—
0
10
18
192
0.94
0.05
1.2
1.1
—
—
—
0
0
43
415
1.04
0.05
1.2
1.2
—
—
—
0
0
85
869
0.98
0.05
1.0
1.1
—
—
—
0
0
2754
27475
1.00
0.05
4.5
4.7
2.8
3.1
ug/l
0.44
2460
24773
55
535
1.03
0.05
1.0
1.1
—
—
—
0
0
598
5945
1.01
0.04
2.7
2.9
213.3
195.7
ng/l
0.18
533
5397
10
91
1.10
0.04
1.1
1.5
—
—
—
0
0
122
1238
0.99
0.04
1.5
1.4
—
—
—
0
0
74
755
0.98
0.04
2.6
3.4
59.3
58.2
%
0.14
46
481
122
1237
0.99
0.04
1.5
1.4
—
—
—
0
0
978
9744
1.00
0.04
1.8
1.8
1.4
1.5
%
1.13
861
8583
6842
68465
1.00
0.03
16.5
14.9
39.8
40.1
%
2.13
5011
50549
14
131
1.07
0.03
2.1
1.1
105.6
78.6
%
—
5
44
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
39
379
1.03
0.03
1.2
1.1
—
—
—
0
0
122
1234
0.99
0.03
1.5
1.4
—
—
—
0
0
122
1234
0.99
0.03
1.5
1.4
—
—
—
0
0
34
350
0.97
0.03
1.9
1.5
—
—
—
0
0
34
350
0.97
0.03
1.9
1.5
—
—
—
0
0
10
108
0.93
0.03
1.3
1.0
—
—
—
0
0
101
998
1.01
0.02
1.1
1.1
3.2
3.3
u/ml
0.02
55
491
1928
19307
1.00
0.02
1.7
1.6
1.4
1.4
mmol/l
0.72
1609
16307
20
208
0.96
0.02
6.7
7.2
—
—
—
0
0
48
489
0.98
0.02
1.7
1.6
3.7
5.2
u/l
0.46
24
231
39
382
1.02
0.01
2.1
1.5
12.7
8.4
ug/l
0.29
32
336
18
173
1.04
0.01
1.5
1.4
23.9
21.8
%
0.13
13
143
103
1039
0.99
0.01
1.5
1.4
0.4
0.4
nmol/l
0.03
82
783
61
618
0.99
0.01
1.4
1.3
11.6
11.8
mmol/l
0.08
19
173
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
30
307
0.98
0.01
2.3
1.9
140.7
154.3
%
0.56
30
286
101
1002
1.01
0.01
1.3
1.3
—
—
—
0
0
66
667
0.99
0.01
1.3
1.3
—
—
—
0
0
70
694
1.01
0.00
1.5
2.1
14.0
7.3
umol/l
0.47
53
491
78
774
1.01
0.00
1.7
1.4
53257.3
66554.1
e6/l
0.17
43
464
10
104
0.96
0.00
1.3
1.0
—
—
—
0
0
15
150
1.00
0.00
5.0
4.5
29.1
91.0
u/l
—
7
51
22
221
1.00
0.00
1.4
1.1
—
—
—
0
0
66
660
1.00
0.00
5.0
5.0
155.8
59.3
u/ml
0.68
22
198
43
434
0.99
0.00
1.1
1.1
1.1
1.0
ratio
1.02
19
140
28
284
0.99
0.00
2.4
2.8
27.0
28.4
umol/l
0.38
19
204
69
688
1.00
0.00
1.4
1.3
1.7
1.5
nmol/l
0.58
59
619
13
128
1.02
0.00
2.2
1.5
—
—
—
0
0
251
2506
1.00
0.00
1.9
1.8
38.2
40.4
nmol/l
0.71
245
2432
203
2027
1.00
0.00
2.1
2.0
10.7
11.4
mg/l
0.51
187
1898
5
58
0.86
0.00
6.6
4.5
—
—
—
0
0
7
70
1.00
0.00
1.0
1.1
—
—
—
0
0
7
78
0.90
0.00
1.1
1.3
—
—
—
0
0
6
69
0.87
0.00
1.3
1.1
—
—
—
0
0
7
70
1.00
0.00
2.6
2.4
—
—
—
0
0
5
59
0.85
0.00
1.0
1.1
9.4
15.1
u/l
—
5
59
8
86
0.93
0.00
1.0
1.1
—
—
—
0
0
7
73
0.96
0.00
2.4
2.4
25.9
20.5
mg/l
—
7
68
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
97
0.93
0.00
1.2
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
8.2
—
15.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint APPENDACUT_COMPLIC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| APPENDACUT_COMPLIC | 1.249 [1.12, 1.4] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 1325 out of 13079 females with APPENDACUT_COMPLIC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| APPENDACUT_COMPLIC | 1.119 [1.01, 1.25] | 0.04 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1714 out of 14440 males with APPENDACUT_COMPLIC died.
Mortality risk
Mortality risk for people of age
years, who have APPENDACUT_COMPLIC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.088% | 0.216% |
| 5 | 0.567% | 1.277% |
| 10 | 1.541% | 3.117% |
| 15 | 2.994% | 5.806% |
| 20 | 5.332% | 10.039% |
Relationships between endpoints
↥Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data