appendicitis: Acute inflammation of the vermiform appendix.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
9164 |
4. Check minimum number of eventsNone |
9164 |
5. Include endpointsNone |
9164 |
6. Filter based on genotype QC (FinnGen only) |
9164 |
Control definitions (FinnGen only)
- Control exclude
- K11_APPENDIX
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Acute appendicitis, with complications
based on the number of shared cases.
Similar with more cases:
- Acute appendicitis
- Appendicitis, broad definition
- Diseases of appendix
- Gastrointestinal diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 84045 | 36878 | 46560 |
Only index persons | 72602 | 32822 | 39780 |
Unadjusted period prevalence (%) | |||
Whole population | 1.19 | 1.06 | 1.30 |
Only index persons | 1.38 | 1.21 | 1.52 |
Median age at first event (years) | |||
Whole population | 33.29 | 33.34 | 32.99 |
Only index persons | 30.31 | 30.74 | 29.95 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 9164 | 4436 | 4728 |
Unadjusted period prevalence (%) | 1.81 | 1.51 | 2.08 |
Median age at first event (years) | 33.67 | 30.89 | 36.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 8367
- Matched controls
- 83666
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint APPENDACUT_COMPLIC and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
APPENDACUT_COMPLIC | 1.249 [1.12, 1.4] | < 0.001 |
Birth year | 0.992 [0.98, 1.0] | 0.049 |
During the follow-up period (1.1.1998 — 31.12.2019), 1325 out of 13079 females with APPENDACUT_COMPLIC died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
APPENDACUT_COMPLIC | 1.119 [1.01, 1.25] | 0.04 |
Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 1714 out of 14440 males with APPENDACUT_COMPLIC died.
Mortality risk
Mortality risk for people of age
years, who have APPENDACUT_COMPLIC.N-year risk | Females | Males |
---|---|---|
1 | 0.088% | 0.216% |
5 | 0.567% | 1.277% |
10 | 1.541% | 3.117% |
15 | 2.994% | 5.806% |
20 | 5.332% | 10.039% |
Relationships between endpoints
↥Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications
GWS hits: 3