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Myocardial infarction, strict

I9_MI_STRICT

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Check only main diagnosis Yes, side diagnoses are not checked
Hospital Discharge: ICD-10 I21, I22
Hospital discharge: ICD-9 410
Hospital discharge: ICD-8 410
Hospital discharge: excluded ICD-10 I21.90, I21.97, I22.90, I22.97
Cause of death: ICD-10 I21, I22
Cause of death: ICD-9 410
Cause of death: ICD-8 410
Cause of death: excluded ICD-10 I21.90, I21.97, I22.90, I22.97

2 out of 7 registries used, show all original rules.

27016

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Check minimum number of events None

27016

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Include endpoints None

27016

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Remove individuals based on genotype QC

26060

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I9_MI_STRICT

Control definitions

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4

Summary Statistics

Key figures

All Female Male
Number of individuals 26060 6715 19345
Unadjusted prevalence (%) 6.33 2.92 10.64
Mean age at first event (years) 66.33 69.42 65.26

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.19 [0.13, 0.29] 3.1e-15 10751
15 years 0.01 2.09 [1.89, 2.31] 5.4e-48 3499
5 years 0.00 3.47 [3.21, 3.76] <1e-100 2146
1 year 0.01 28.91 [26.33, 31.75] <1e-100 3845

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_MI_STRICT – Myocardial infarction, strict
GWS hits: 55

Survival analyses between endpoints

Plot

before Myocardial infarction, strict
after Myocardial infarction, strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Myocardial infarction, strict