Depression medications

ANTIDEPRESSANTS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

154737

6. Filter based on genotype QC (FinnGen only)

154737

Control definitions (FinnGen only)

Control exclude
NEURO_COMORBIDITIES

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1301037 797631 495459
Only index persons 1186033 738521 447512
Unadjusted period prevalence (%)
Whole population 19.33 22.85 13.84
Only index persons 23.35 27.15 17.08
Median age at first event (years)
Whole population 45.17 45.51 44.51
Only index persons 43.34 43.69 42.76

-FinnGen-

Key figures

All Female Male
Number of individuals 154737 101483 53254
Unadjusted period prevalence (%) 30.77 34.59 23.48
Median age at first event (years) 44.49 42.23 48.81

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
170
Matched controls
1350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH04
ATC
quetiapine; oral
445.8
67.5
68
*
N06AB03
ATC
fluoxetine; oral
801.2
64.5
64
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
152.0
63.9
69
6
N06AB10
ATC
escitalopram; oral
157.3
58.3
63
5
N06AB06
ATC
sertraline; oral
337.2
55.2
57
*
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
118.4
52.9
59
6
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
29.0
49.7
73
34
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
151.4
48.5
53
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
117.9
46.4
52
5
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
45.8
44.9
58
15
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
124.0
41.2
46
*
IGP01
NOMESCO Finland
Psychiatric family contact
199.3
36.1
39
*
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
192.7
35.1
38
*
IGY99
NOMESCO Finland
Other psychiatric treatment contact
132.8
35.0
39
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
99.6
34.0
39
*
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
+∞
32.7
33
*
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
337.8
32.2
34
*
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
119.9
32.0
36
*
N05AX08
ATC
risperidone; systemic
56.7
31.5
39
7
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
325.1
31.2
33
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
312.6
30.2
32
*
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
30.2
29.0
41
14
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
62.0
26.2
32
5
F90.0
ICD-10 Finland
Disturbance of activity and attention
16.8
24.0
41
25
P01
ICPC
Feeling anxious/nervous/tense
8.8
23.1
56
71
IGV01
NOMESCO Finland
Psychiatric network contact
121.0
23.0
26
*
N05AX12
ATC
aripiprazole; systemic
115.5
22.0
25
*
F93.89
ICD-10 Finland
Other childhood emotional disorders
115.5
22.0
25
*
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
+∞
21.5
22
*
N06AX26
ATC
vortioxetine; oral
+∞
21.5
22
*
N06AX16
ATC
venlafaxine; oral
209.7
21.1
23
*
N05BA04
ATC
oxazepam; oral
110.1
21.1
24
*
SPAT1389
SPAT
Visit based on need for special support
7.3
20.0
55
83
N06BA04
ATC
methylphenidate; oral
14.9
19.7
35
23
SPAT1307
SPAT
Psychosocial counselling and guidance
7.5
19.4
52
75
P76
ICPC
Depressive disorder
38.5
18.9
25
6
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
+∞
18.5
19
*
IEP03
NOMESCO Finland
Focused parental counselling
49.7
17.5
22
*
N06AX11
ATC
mirtazapine; oral
62.8
17.3
21
*
N06AX12
ATC
bupropion; oral
89.4
17.2
20
*
P03
ICPC
Feeling depressed
9.4
17.1
38
40
IEP99
NOMESCO Finland
Other psychiatric family intervention
56.2
15.4
19
*
N05AH03
ATC
olanzapine; systemic
79.4
15.3
18
*
IEV99
NOMESCO Finland
Other psychiatric network intervention
149.0
15.3
17
*
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
+∞
14.5
15
*
F32.1
ICD-10 Finland
Moderate depressive episode
74.5
14.3
17
*
C07AA05
ATC
propranolol; systemic
14.6
13.7
24
15
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
+∞
13.5
14
*
SPAT1240
SPAT
Therapeutic discussion
7.7
13.3
33
41
P74
ICPC
Anxiety disorder/anxiety state
17.1
12.8
21
11
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
+∞
12.6
13
*
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
+∞
12.6
13
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
+∞
12.6
13
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
21.0
12.5
19
8
F84.5
ICD-10 Finland
Asperger syndrome
22.6
12.1
18
7
F32
ICD-10 Finland
Depressive episode
34.8
12.0
16
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
19.8
11.6
18
8
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
55.5
10.6
13
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
+∞
10.6
11
*
R5599
NOMESCO Finland
Other rehabilitation service
25.9
10.5
15
5
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
101.9
10.5
12
*
F40.1
ICD-10 Finland
Social phobias
30.1
10.2
14
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
14.8
10.0
17
10
F41.1
ICD-10 Finland
Generalized anxiety disorder
37.0
9.9
13
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
50.9
9.7
12
*
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
+∞
9.6
10
*
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
18.5
9.6
15
7
N06AB04
ATC
citalopram; systemic
92.8
9.6
11
*
IEP01
NOMESCO Finland
Psychoeducation, family
92.8
9.6
11
*
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
92.8
9.6
11
*
IEP02
NOMESCO Finland
Child-centred family therapy
33.9
9.0
12
*
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
46.4
8.8
11
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.6
8.7
26
42
F41.00
ICD-10 Finland
Moderate panic disorder
+∞
8.6
9
*
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
+∞
8.6
9
*
F34.1
ICD-10 Finland
Dysthymia
+∞
8.6
9
*
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
25.4
8.5
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.6
8.4
25
40
Z07
ICPC
Education problem
9.9
8.4
17
15
N03AX09
ATC
lamotrigine; oral
20.3
8.0
12
5
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
41.9
7.9
10
*
P06
ICPC
Sleep disturbance
7.2
7.8
19
23
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.7
7.7
27
52
N02BE01
ATC
paracetamol; systemic, rectal
2.6
7.7
77
325
H03AA01
ATC
levothyroxine sodium; systemic
75.0
7.7
9
*
N06AX21
ATC
duloxetine; oral
75.0
7.7
9
*
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
+∞
7.7
8
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
+∞
7.7
8
*
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
+∞
7.7
8
*
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
+∞
7.7
8
*
Z71.8
ICD-10 Finland
Other specified counselling
3.1
7.2
45
140
D01
ICPC
Abdominal pain/cramps general
3.0
7.2
48
157
F41.8
ICD-10 Finland
Other specified anxiety disorders
37.5
7.0
9
*
C07AB07
ATC
bisoprolol; oral
8.6
7.0
15
15
F51.0
ICD-10 Finland
Nonorganic insomnia
7.7
7.0
16
18
T36
ICD-10 Finland
Poisoning by systemic antibiotics
15.4
6.8
11
6
F39
ICD-10 Finland
Unspecified mood [affective] disorder
+∞
6.7
7
*
IER05
NOMESCO Finland
Rehabilitative psychiatric group intervention, social skills
+∞
6.7
7
*
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
+∞
6.7
7
*
IAB03
NOMESCO Finland
Neuropsychiatric consultation
+∞
6.7
7
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
+∞
6.7
7
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
+∞
6.7
7
*
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
+∞
6.7
7
*
R51.80
ICD-10 Finland
Headache
3.5
6.7
32
83
N03AX16
ATC
pregabalin; oral
10.0
6.6
13
11
K30
ICD-10 Finland
Functional dyspepsia
11.3
6.5
12
9
R4190
NOMESCO Finland
Nutritional therapy
5.2
6.5
20
34
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
6.4
38
113
F41.09
ICD-10 Finland
UNS Panic Syndrome
25.0
6.4
9
*
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
25.0
6.4
9
*
M03BX02
ATC
tizanidine; oral
6.1
6.4
17
24
D11
ICPC
Diarrhoea
3.5
6.1
29
75

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
1223
1606
3.99
323.31
3.6
2.5
77.6
65.6
ng/l
3.02
1090
1448
5713
16884
1.93
321.98
4.7
3.1
—
—
—
0
0
4589
12542
2.05
320.89
2.3
1.5
—
—
—
0
0
903
911
5.15
319.19
11.2
7.5
24.2
24.3
mmol/l
0.25
839
866
885
876
5.25
318.69
3.1
1.7
0.7
0.7
%
0.17
843
822
2405
4951
2.61
317.97
5.8
2.5
—
—
—
0
0
19488
84238
2.03
309.19
4.2
2.7
2.9
3.1
mmol/l
171.24
18307
79883
2232
4486
2.66
308.34
1.2
1.2
143.7
111.2
iu/ml
2.16
806
1684
2854
5866
2.65
307.65
2.2
1.5
—
—
—
0
0
3692
3977
5.37
307.65
1.7
1.5
1159.8
1137.2
nmol/l
0.58
2896
2942
4803
8501
3.32
307.65
4.6
2.4
—
—
—
0
0
16433
59839
2.31
307.65
3.7
2.0
44.9
31.3
u/l
80.03
15619
57643
3096
7035
2.40
307.65
2.7
1.9
3.4
3.2
e6/l
0.23
1542
3560
1055
1035
5.33
307.65
2.7
1.4
114.9
59.7
ng/l
1.70
908
896
2564
3824
3.67
307.65
3.0
1.3
—
—
—
0
0
11833
28136
3.28
307.65
4.9
2.4
6.4
5.9
mmol/l
105.63
10966
24212
2870
5870
2.67
307.65
2.8
1.3
—
—
—
0
0
5717
12702
2.68
307.65
7.2
4.0
—
—
—
0
0
1642
1687
5.19
307.65
9.3
5.5
—
—
—
0
0
1079
1102
5.12
307.65
7.7
4.1
24.5
24.4
mmol/l
0.54
1017
1001
6029
14185
2.54
307.65
3.1
2.0
71.7
68.5
e6/l
0.06
4575
10111
11021
31528
2.45
307.65
6.3
4.6
29.7
31.0
%
31.56
10369
29772
1753
2434
3.84
307.65
2.7
2.0
1.8
1.5
%
24.12
1554
2172
3593
8548
2.32
307.65
1.4
1.3
464.1
576.3
titre
2.26
582
1562
1806
1933
5.01
307.65
4.2
2.2
5.9
5.9
kpa
0.35
1742
1879
562
0
+∞
307.65
14.5
0.0
848.7
—
nmol/l
—
547
0
4819
6901
4.17
307.65
1.5
1.2
19.4
21.1
nmol/l
9.41
4303
5975
21581
92954
3.44
307.65
12.4
4.8
—
—
—
0
0
6093
10196
3.72
307.65
2.4
1.6
245.1
209.6
u/l
0.71
5779
9663
2724
4097
3.66
307.65
2.2
1.5
29.5
28.7
s
9.65
2639
3966
1590
1513
5.60
307.65
7.8
3.7
7.4
6.2
mmol/l
9.97
1527
1445
9133
30648
1.82
307.65
4.0
3.3
—
—
—
0
0
10719
22581
3.58
307.65
5.7
2.6
10.2
11.1
umol/l
9.63
10039
21074
3432
5638
3.42
307.65
3.3
1.5
273.7
281.3
ng/l
0.03
1991
2536
12917
34809
2.96
307.65
10.2
4.9
4.1
3.9
e9/l
16.00
11426
30685
9531
22592
2.91
307.65
2.4
1.9
70.8
74.9
nmol/l
31.67
8825
21224
2958
5788
2.80
307.65
3.0
1.3
—
—
—
0
0
21823
91602
4.39
307.65
10.2
4.8
29.1
26.1
u/l
60.61
21236
88495
1633
1644
5.30
307.65
9.5
5.8
125.6
128.1
g/l
3.02
1582
1564
18125
73663
2.09
307.65
16.2
6.0
13.4
13.3
%
17.64
17769
71745
2618
4890
2.91
307.65
2.7
1.9
6.9
6.4
umol/l
0.62
2195
4214
14163
48946
2.17
307.65
4.1
2.9
—
—
—
0
0
3421
5395
3.57
307.65
2.4
1.6
2.4
2.4
mmol/l
6.98
2979
4638
10346
35613
1.83
307.65
3.4
2.4
0.0
0.0
estimate
1.82
2142
6123
1776
2606
3.63
307.65
13.5
2.1
1.1
1.0
inr
4.15
292
535
2845
5168
3.02
307.65
3.0
1.3
—
—
—
0
0
1800
1912
5.05
307.65
4.2
2.2
1.9
2.0
mmol/l
0.66
1431
1560
9888
28401
2.31
307.65
9.1
5.4
0.0
0.0
e9/l
1.73
8099
23639
10281
35115
1.85
307.65
3.4
2.4
0.0
0.0
estimate
1.08
2106
5907
1962
615
17.44
307.65
3.3
1.8
—
—
—
0
0
7187
11731
4.02
307.65
2.8
1.5
2.3
2.4
mmol/l
0.23
6471
10354
19500
74088
3.04
307.65
4.1
2.3
5.8
5.4
mmol/l
299.56
18181
69581
1966
2035
5.22
307.65
8.5
5.2
5.1
5.0
kpa
6.37
1888
1944
3295
4765
3.89
307.65
2.3
1.6
14.5
20.7
umol/l
0.84
3048
4446
11804
32782
2.65
307.65
6.3
4.6
2.0
2.0
e9/l
3.74
10593
29825
5077
14172
2.03
307.65
3.6
2.4
1.0
1.0
kg/l
2.25
596
2350
1107
1196
4.84
307.65
3.5
1.8
134.4
140.6
g/l
11.83
1078
1180
1643
2041
4.28
307.65
3.8
1.7
1.2
1.2
mmol/l
0.69
1390
1721
1107
1036
5.60
307.65
5.3
3.1
—
—
—
0
0
5526
12935
2.51
307.65
2.9
2.0
—
—
—
0
0
21010
74662
5.44
307.65
13.5
4.1
3.9
3.9
mmol/l
7.52
20440
71494
1300
1461
4.68
307.65
3.1
2.2
5.2
5.1
kpa
1.22
1229
1352
2287
2670
4.67
307.65
7.8
4.4
104.3
105.0
mmol/l
8.79
2236
2621
20486
68087
5.42
307.65
5.3
2.4
1.9
2.2
mu/l
1.44
19438
63569
3315
7412
2.46
307.65
2.5
1.9
1.0
0.9
e6/l
1.43
1751
3908
13484
44384
2.26
307.65
4.2
2.8
1103.4
1214.3
e6/l
0.10
178
460
10885
31112
2.43
307.65
6.1
4.5
56.1
55.3
%
10.82
10260
29573
3255
3563
5.18
307.65
3.5
2.0
0.8
0.8
mmol/l
24.29
3049
3323
4259
9118
2.65
307.65
2.5
1.8
7.0
6.4
e6/l
1.51
3755
7730
8695
16184
3.73
307.65
4.6
3.1
37.0
37.9
g/l
35.60
8099
14999
14014
38910
3.05
307.65
3.2
1.8
—
—
—
0
0
6799
14021
3.04
307.65
3.1
1.5
39.7
15.0
ng/l
2.33
3442
4826
17819
65222
2.62
307.65
5.0
2.2
38.1
35.5
mmol/mol
227.55
16760
61909
1507
1636
4.89
307.65
3.5
2.0
4.9
4.7
kpa
1.79
1452
1591
3009
4057
4.14
307.65
2.3
1.5
2.5
2.5
g/l
3.77
2773
3789
1875
3193
3.13
307.65
3.4
2.1
—
—
—
0
0
2268
4011
3.05
307.65
2.7
1.9
56.2
50.3
u/l
0.10
1944
3468
16040
43235
3.81
307.65
7.1
4.0
74.9
70.7
u/l
30.11
15156
40344
1081
1051
5.38
307.65
4.3
2.3
24.2
24.5
mmol/l
2.04
964
952
1233
1330
4.87
307.65
2.4
1.3
6.7
3.3
ug/l
3.94
1081
1156
5264
10984
2.83
307.65
4.0
2.2
95.8
96.9
%
2.58
5111
10665
2995
6186
2.65
307.65
1.2
1.1
—
—
—
0
0
8661
18280
3.21
307.65
3.4
2.2
33.0
28.8
u/l
1.55
8206
17559
6574
16973
2.32
307.65
1.3
1.2
1.5
2.0
u/ml
1.69
1819
5061
4682
5924
4.73
307.65
4.1
2.1
10.2
12.0
mg/mmol
0.99
3073
3307
593
296
10.32
307.65
3.1
2.9
36.4
34.3
umol/l
0.45
514
252
1315
1385
5.00
307.65
7.0
5.3
24.7
24.8
mmol/l
0.18
1299
1380
10637
29573
2.50
307.65
6.7
4.9
8.2
8.1
%
0.10
10036
28043
5269
14116
2.14
307.65
1.6
1.4
1.6
1.2
mmol/l
63.23
4538
12585
11403
30888
2.69
307.65
6.3
4.7
0.6
0.5
e9/l
24.16
10041
27628
577
0
+∞
307.65
19.9
0.0
1441.1
—
nmol/l
—
562
0
5469
9801
3.37
307.65
2.2
1.8
2.8
2.4
mg/l
25.17
4720
8379
2783
5819
2.60
307.65
1.8
1.4
—
—
—
0
0
7685
17565
2.80
307.65
5.8
5.3
—
—
—
0
0
1105
819
7.08
307.65
1.5
1.2
—
—
—
0
0
2012
2438
4.45
307.65
2.4
2.2
0.2
0.2
g/l
2.79
1868
2298
4516
5651
4.75
307.65
3.4
1.9
445.3
693.9
mg/l
1.42
2946
3069
20966
74157
5.42
307.65
13.5
4.1
139.6
139.8
mmol/l
38.36
20436
71248
6481
8451
4.97
307.65
3.5
1.8
8.4
9.1
mmol/l
11.10
5594
7437
5005
11233
2.58
307.65
1.8
1.4
0.9
0.8
mg/l
1.44
3585
8012
2969
5889
2.76
307.65
3.0
1.3
—
—
—
0
0
11444
30976
2.70
307.65
6.3
4.8
0.0
0.0
e9/l
2.61
10063
27671
6027
17181
2.03
307.65
2.3
1.5
—
—
—
0
0
783
220
18.50
307.65
5.6
2.7
373.4
384.6
umol/l
0.46
689
181
2962
5882
2.76
307.65
2.9
1.2
—
—
—
0
0
15777
50374
2.80
307.65
3.8
2.9
9.1
7.5
mm/h
56.78
14741
47215
20844
83671
3.51
307.65
13.2
5.3
19.5
21.1
mg/l
9.29
16496
57945
9831
16865
4.36
307.65
6.2
3.0
1.2
1.2
mmol/l
20.49
8245
14469
18484
53589
4.63
307.65
4.4
2.1
14.4
14.2
pmol/l
10.12
17221
48945
5977
9002
4.15
307.65
3.6
2.0
7.4
7.4
ph
0.16
1201
1344
1848
1994
4.98
307.65
4.1
2.1
7.4
—
ph
—
11
0
1288
1441
4.70
307.65
3.0
2.2
7.4
7.4
ph
2.63
173
133
10246
28175
2.49
307.65
6.4
4.8
0.7
0.7
%
3.20
9615
26528
2671
2854
5.19
307.65
5.8
3.5
1.0
1.0
mmol/l
3.64
2491
2660
6914
12269
3.62
307.65
6.2
2.0
1.1
1.1
inr
1.16
2362
4202
10583
29374
2.50
307.65
6.3
4.7
2.8
2.9
%
6.04
9919
27623
1956
2033
5.19
307.65
8.5
5.2
1.0
0.8
mmol/l
0.81
1537
1480
7160
19106
2.28
307.65
3.6
2.4
54.9
64.4
e6/l
0.65
4917
11563
4518
7241
3.66
307.65
1.6
1.3
29446865.2
46359387.7
pmol/l
0.90
3902
6413
11785
32425
2.69
307.65
6.8
4.7
0.2
0.2
e9/l
1.06
10539
29341
3956
8101
2.76
307.65
2.6
1.8
538.8
584.5
mosm/kgh2o
19.20
3422
6709
500
121
21.23
307.65
2.8
3.0
—
—
—
0
0
11489
32847
2.51
307.65
3.0
2.2
91.1
72.1
ug/l
18.04
10794
31402
1965
2034
5.22
307.65
8.5
5.2
12.4
14.4
kpa
23.53
1889
1943
5476
13860
2.29
307.65
2.7
1.8
—
—
—
0
0
5004
9905
2.97
307.65
3.1
1.7
—
—
—
0
0
5545
12534
2.61
307.65
3.0
2.0
0.3
0.2
e6/l
1.23
4133
8692
8997
14590
4.44
307.65
5.6
2.8
1.2
1.2
mmol/l
14.71
8185
12983
1227
1499
4.29
307.65
2.4
1.8
75.1
67.0
e9/l
7.68
898
1099
10278
35276
1.84
307.65
4.5
3.3
0.0
0.0
estimate
1.23
2206
6178
3544
4076
4.98
307.65
2.8
1.3
761.9
251.6
ng/l
13.04
2779
2950
7152
14974
3.03
307.65
2.8
1.7
53.9
59.2
u/l
9.38
6552
13934
2819
2927
5.38
307.65
2.0
1.6
370.9
383.8
nmol/l
2.10
2583
2740
2729
3570
4.23
307.65
2.4
1.6
24.0
27.2
%
15.74
2342
3102
2478
2709
5.03
307.65
4.0
1.4
—
—
—
0
0
1746
1857
5.03
307.65
7.6
4.7
1.4
1.3
mmol/l
1.36
1672
1785
1747
1727
5.42
307.65
9.0
5.6
95.9
96.7
%
3.27
1698
1651
8441
14817
3.94
307.65
1.9
1.4
98.2
100.2
pmol/l
2.56
4735
7632
1832
2187
4.49
307.65
3.1
3.1
4.5
4.8
pmol/l
16.01
1636
2020
5652
14307
2.31
307.65
1.5
1.3
2.2
2.1
g/l
3.46
3521
9736
914
980
4.84
303.66
11.6
6.0
—
—
—
0
0
1203
1670
3.77
295.87
1.9
1.4
67.2
68.7
g/l
6.79
1122
1556
768
709
5.60
295.09
5.2
2.7
—
—
—
0
0
3847
10128
2.09
293.65
2.4
2.9
103.8
125.4
ug/g
3.19
2979
8242
657
510
6.64
292.50
3.7
1.9
7.4
7.4
ph
1.02
561
421
761
703
5.60
292.20
2.5
2.0
471.5
425.5
ug/l
0.16
705
626
1889
3579
2.80
289.76
2.3
2.2
10.3
10.9
g/l
11.07
1734
3288
4666
13311
1.96
286.19
2.3
1.6
2551.0
3455.7
umol/l
1.06
4122
12099
19313
83877
1.95
283.76
4.0
2.6
4.7
5.0
mmol/l
245.02
18255
80201
928
1078
4.47
282.68
3.0
2.4
—
—
—
0
0
4261
11833
1.99
281.11
1.8
1.6
—
—
—
0
0
22607
105368
4.22
281.06
20.6
7.2
262.1
256.2
e9/l
36.29
22237
102191
663
547
6.25
280.88
4.2
2.7
1.4
1.3
mmol/l
0.60
656
542
2487
5567
2.40
275.76
2.5
1.8
12.6
14.1
nmol/l
13.20
2224
5237
378
124
15.58
273.45
2.4
2.1
134.2
73.1
ug/min
0.75
246
81
22614
105640
4.16
271.26
20.5
7.2
30.1
30.1
pg
3.70
22401
104081
22614
105657
4.15
270.49
20.5
7.2
90.0
89.6
fl
27.07
22400
104085
22618
105690
4.17
270.43
20.6
7.2
4.6
4.6
e12/l
33.87
22210
102318
464
243
9.78
269.28
2.8
2.0
0.9
0.8
nmol/l
0.95
384
224
19167
83423
1.90
269.16
3.9
2.6
1.4
1.5
mmol/l
280.34
18046
79783
5714
17747
1.82
269.09
3.7
2.5
0.0
0.0
estimate
0.04
2131
6073
22621
105761
4.16
268.29
20.7
7.3
6.8
6.5
e9/l
115.60
22212
102353
4206
11806
1.97
267.93
1.3
1.2
21.6
31.1
iu/ml
1.97
1200
3880
579
428
6.96
267.62
3.7
1.9
9.1
9.2
kpa
0.64
563
422
22620
105802
4.13
266.10
20.7
7.3
137.9
139.3
g/l
44.43
22403
104246
576
427
6.93
265.64
3.7
1.8
2.1
1.8
mmol/l
1.97
366
240
576
427
6.93
265.64
3.7
1.8
5.0
5.0
kpa
0.87
561
421
18506
79801
1.83
263.53
3.6
2.4
1.4
1.2
mmol/l
203.87
17356
76396
1235
1931
3.34
257.11
1.4
1.2
—
—
—
0
0
8113
28347
1.68
250.63
3.4
2.3
—
—
—
0
0
814
936
4.50
250.47
3.6
2.0
25.2
25.5
mmol/l
1.61
784
896
548
411
6.85
250.43
3.1
1.8
—
—
—
0
0
952
1267
3.90
246.48
1.8
1.3
—
—
—
0
0
1219
1948
3.27
245.51
3.8
2.1
16.8
7.8
ug/l
1.00
950
1284
831
1016
4.23
238.38
3.0
2.3
24.7
24.8
mmol/l
0.28
787
964
561
470
6.13
234.43
4.3
2.8
3.8
3.8
mmol/l
0.48
532
449
3895
11102
1.92
234.10
1.3
1.2
6.4
11.0
u/ml
4.65
1549
4886
4737
14433
1.82
232.04
3.4
2.5
—
—
—
0
0
694
745
4.80
229.75
1.4
1.3
293.9
338.4
ug/g
3.92
364
376
466
316
7.55
229.33
1.7
1.2
1.4
1.6
promille
0.93
352
253
1445
2683
2.82
228.02
1.8
1.6
1.3
1.2
g/l
0.48
1342
2502
2451
5908
2.22
228.01
1.2
1.1
—
—
—
0
0
1827
3869
2.49
225.19
4.4
3.8
0.8
0.4
%
4.86
466
566
598
585
5.25
217.21
2.1
1.5
2.0
1.6
ug/l
0.34
543
506
462
347
6.81
210.78
3.3
2.0
—
—
—
0
0
7634
27192
1.62
209.16
1.9
1.6
—
—
—
0
0
1866
4166
2.36
205.30
1.6
1.4
331.6
270.6
mu/l
6.30
1666
3811
445
333
6.84
203.59
1.1
1.1
17442.1
9.0
iu/ml
0.50
127
91
1687
3607
2.46
203.20
4.1
3.6
0.5
0.3
%
3.12
337
440
274
85
16.40
202.34
2.8
1.4
163.1
126.6
umol/l
0.42
139
38
481
404
6.10
200.47
2.3
1.5
17.2
18.6
%
6.82
227
174
1727
3792
2.40
196.59
4.5
3.8
0.1
0.0
%
2.16
427
539
673
823
4.21
192.70
1.8
1.7
1.5
1.1
g/l
12.94
580
709
1650
3677
2.35
181.48
4.5
3.9
0.0
0.0
%
1.08
355
474
490
473
5.30
180.15
3.0
2.0
24.4
24.5
mmol/l
0.01
449
412
847
1305
3.35
179.24
2.1
1.6
20.9
20.3
s
2.02
716
1073
2538
6802
1.99
177.72
1.5
1.3
—
—
—
0
0
1532
3373
2.38
172.68
3.3
2.4
—
—
—
0
0
1391
2935
2.47
171.30
1.5
1.3
8.1
7.7
u/l
0.57
1123
2469
2320
6111
2.01
169.88
1.3
1.4
—
—
—
0
0
802
1243
3.33
168.16
1.3
1.1
435.9
428.4
mg/l
0.19
751
1187
503
535
4.81
167.89
2.8
2.8
8.7
9.2
kpa
4.72
471
495
379
297
6.51
167.19
1.9
1.3
1.8
1.7
mmol/l
0.23
374
292
950
1667
2.95
164.07
2.1
1.7
197.3
208.1
pmol/l
1.77
905
1620
621
824
3.87
160.83
6.5
2.9
0.9
0.9
%
0.20
583
777
303
188
8.20
158.38
1.5
1.5
64.5
76.9
mmol/l
1.78
244
154
2082
5404
2.03
158.01
3.7
2.3
—
—
—
0
0
354
275
6.56
157.25
2.5
1.9
—
—
—
0
0
625
852
3.77
156.34
6.4
2.8
2.0
1.6
%
5.22
585
801
156
11
71.83
155.28
2.9
1.8
—
—
—
0
0
6011
21424
1.56
153.66
2.9
2.0
—
—
—
0
0
279
161
8.81
152.75
1.6
1.5
283.8
284.9
mosm/kgh2o
0.23
221
130
207
65
16.16
152.18
1.5
1.3
1.5
1.7
nmol/l
0.55
189
60
7374
27659
1.50
147.99
2.2
1.9
—
—
—
0
0
706
1098
3.31
147.13
1.4
1.2
6359.0
545.9
e6/l
0.56
560
882
705
1097
3.30
146.81
1.4
1.1
15.7
10.6
e6/l
0.80
526
846
1306
2906
2.34
143.18
2.0
1.6
36.3
41.5
nmol/l
10.13
1272
2880
636
941
3.47
142.38
2.8
1.9
—
—
—
0
0
347
297
5.95
142.26
1.7
1.3
—
—
—
0
0
1074
2189
2.54
141.20
1.2
1.2
1.0
0.6
u/ml
0.40
87
139
19709
90471
1.64
141.08
14.5
5.5
40.8
41.2
%
12.63
15566
78087
1181
2527
2.42
140.70
1.1
1.1
2.6
6.5
u/ml
0.45
19
30
681
1093
3.20
135.31
1.2
1.1
3.7
3.5
mmol/l
5.87
637
1029
177
50
17.94
135.08
2.1
3.0
14.8
21.3
umol/l
2.55
177
50
580
850
3.50
131.54
6.7
2.7
1.3
1.2
mmol/l
2.27
511
750
651
1038
3.22
130.62
1.4
1.1
—
—
—
0
0
807
1470
2.83
130.47
1.7
1.8
1.2
1.1
g/l
9.72
770
1406
249
155
8.16
129.90
7.0
4.6
10.1
9.3
mg/l
1.27
229
142
1252
2858
2.27
129.38
1.5
1.3
—
—
—
0
0
1507
3729
2.11
128.43
1.4
1.3
—
—
—
0
0
782
1412
2.85
128.35
1.7
1.8
0.2
0.2
g/l
5.68
747
1346
154
34
22.94
126.62
2.7
1.3
—
—
—
0
0
772
1396
2.84
126.37
1.2
1.3
71.1
129.3
titre
0.78
79
127
2541
7626
1.76
123.16
1.5
1.5
—
—
—
0
0
856
1667
2.64
122.60
1.5
1.6
8.7
11.0
u/ml
0.36
21
77
1435
3549
2.10
122.29
1.1
1.0
—
—
—
0
0
744
1353
2.83
120.55
1.2
1.3
602.2
1332.1
titre
1.51
18
38
2284
6703
1.79
119.01
1.2
1.1
—
—
—
0
0
599
978
3.14
115.84
1.1
1.1
—
—
—
0
0
2133
6179
1.81
115.75
2.5
2.1
5691.0
6817.6
u/l
0.78
719
2872
354
384
4.69
115.72
2.7
1.5
1.2
1.1
ratio
0.60
39
46
371
423
4.47
114.91
8.5
3.9
11.6
11.4
mmol/l
0.33
336
376
363
406
4.55
114.83
2.8
1.6
32.1
26.2
mg/l
1.08
280
334
371
424
4.46
114.61
8.5
3.9
105.1
105.4
mmol/l
0.48
336
377
517
773
3.42
113.95
1.8
1.2
3.8
3.7
g/l
0.43
396
551
1771
4871
1.90
112.61
2.3
2.3
21.4
20.7
au/ml
0.10
105
531
361
410
4.48
112.30
2.8
1.6
42.0
30.0
mg/l
2.46
277
338
614
1054
2.98
109.60
3.7
2.6
1.3
1.0
mg/l
16.59
583
999
1600
4293
1.94
109.21
1.2
1.2
—
—
—
0
0
565
925
3.13
108.78
1.1
1.0
—
—
—
0
0
1644
4460
1.92
108.69
1.3
1.3
47.2
47.2
au/ml
0.00
54
235
478
704
3.47
107.62
1.8
1.2
10.2
10.4
g/l
0.34
422
601
123
22
28.27
106.52
3.1
2.8
0.8
1.2
nmol/l
—
82
9
659
1201
2.81
106.30
1.6
1.5
—
—
—
0
0
1858
5290
1.83
106.09
1.3
1.3
260.4
262.9
u/ml
0.02
1720
4939
2155
6431
1.76
105.53
3.7
2.6
30.0
32.0
%
12.49
1604
4588
1799
5078
1.85
105.49
1.4
1.3
20.6
25.1
iu/l
6.82
1502
4455
287
280
5.21
104.45
1.8
1.6
59.8
42.9
mu/l
1.04
259
265
1596
4349
1.91
104.01
1.3
1.2
—
—
—
0
0
291
291
5.08
103.39
3.0
1.6
—
—
—
0
0
664
1259
2.70
99.77
2.5
1.9
3.6
3.6
g/l
0.19
630
1189
409
584
3.57
96.12
1.6
1.3
38.8
40.3
g/l
3.85
378
514
402
567
3.61
96.06
1.1
1.0
118.7
117.1
%
0.43
365
493
642
1225
2.68
95.34
1.9
2.1
3.9
3.6
iu/l
0.40
255
525
300
341
4.47
93.28
1.2
1.3
0.3
0.1
nmol/l
0.61
13
12
263
269
4.96
91.40
1.5
1.2
367.6
296.5
pmol/l
1.14
198
204
880
2001
2.26
91.25
2.3
2.1
—
—
—
0
0
335
429
3.97
90.66
1.9
2.5
21.9
23.4
nmol/l
1.21
315
421
1606
4600
1.81
89.40
2.8
1.7
4.1
4.0
e9/l
0.74
1295
3890
296
348
4.32
88.63
1.3
1.3
0.5
3.8
nmol/l
0.49
281
334
1463
4088
1.85
87.97
1.1
1.1
141.1
206.1
titre
0.44
34
137
609
1181
2.64
87.73
1.8
2.1
10.3
9.6
mg/l
0.84
579
1141
654
1336
2.51
85.18
3.1
2.8
0.3
0.3
g/l
0.26
298
536
120
44
13.79
83.06
2.2
1.9
642.2
688.2
ml
0.30
89
39
267
305
4.44
82.60
1.3
1.3
—
—
—
0
0
403
637
3.22
81.89
1.2
1.1
—
—
—
0
0
1091
2823
1.99
81.85
1.8
1.7
—
—
—
0
0
356
518
3.50
81.55
3.2
1.6
—
—
—
0
0
789
1798
2.25
81.33
1.2
1.1
—
—
—
0
0
292
373
3.98
79.30
2.9
2.0
1.1
1.5
%
0.60
228
274
405
657
3.14
79.10
1.3
1.2
3.4
3.4
u/ml
0.04
176
298
607
1241
2.50
78.91
1.4
1.3
18.9
19.4
u/l
0.13
503
1047
434
741
2.98
78.14
3.3
2.8
521.7
79.9
u/ml
0.70
357
637
100
27
18.71
77.51
1.0
1.0
—
—
—
0
0
662
1425
2.38
77.38
1.3
1.2
244.6
227.5
u/ml
0.82
400
904
18214
84784
1.38
76.15
17.4
6.0
333.9
334.3
g/l
7.85
18105
83909
1005
2592
1.99
75.99
1.6
1.7
—
—
—
0
0
435
765
2.90
74.58
2.0
1.9
134.3
137.3
g/l
1.53
331
582
681
1525
2.28
72.99
1.5
1.4
0.4
0.5
nmol/l
1.92
530
1307
108
42
12.99
72.90
6.5
2.0
—
—
—
0
0
5592
22110
1.36
71.83
1.8
1.7
—
—
—
0
0
224
250
4.54
71.14
3.8
1.3
51.9
188.5
u/ml
1.05
63
63
279
376
3.77
70.87
1.2
1.1
37.0
13.7
u/l
1.47
241
329
172
152
5.73
68.72
2.3
2.1
11.4
12.6
%
2.17
172
152
1237
3553
1.79
67.75
1.3
1.2
—
—
—
0
0
251
323
3.94
67.61
1.6
1.2
—
—
—
0
0
228
271
4.27
67.52
1.6
1.3
—
—
—
0
0
530
1095
2.47
67.46
1.5
1.4
8.7
8.2
iu/ml
—
8
17
132
86
7.76
66.93
1.3
1.4
34.9
36.1
mmol/l
0.14
120
78
158
132
6.06
66.29
1.5
1.2
137.3
132.4
nmol/l
0.51
158
132
901
2351
1.97
65.87
2.6
1.8
0.2
0.2
e6/l
0.51
858
2253
2657
18537
0.69
65.38
1.3
1.3
—
—
—
0
0
684
1622
2.16
64.12
1.2
1.3
36.1
37.4
u/ml
0.04
34
104
127
84
7.64
63.74
1.4
1.2
13.6
13.8
pmol/l
0.22
107
75
582
1295
2.29
63.27
1.3
1.2
23.7
21.1
u/ml
0.12
14
32
518
1092
2.42
63.26
3.8
3.4
56.8
55.9
%
0.96
518
1092
265
376
3.58
62.93
1.1
1.1
288.7
279.6
mg/l
0.75
238
347
511
1076
2.42
62.56
3.6
3.4
4.0
3.8
e9/l
2.20
511
1076
80
0
+∞
62.48
7.7
0.0
—
—
—
0
0
251
345
3.69
62.19
1.3
1.1
1.9
1.7
mmol/l
1.83
231
326
580
1303
2.27
61.71
1.4
1.2
—
—
—
0
0
274
405
3.43
61.49
3.8
3.5
35.2
25.3
mu/l
2.73
254
378
332
558
3.02
61.39
1.3
1.1
—
—
—
0
0
334
571
2.97
60.08
1.4
1.4
—
—
—
0
0
4187
16199
1.37
59.96
3.4
2.7
1.5
1.9
ug/l
1.18
3737
15223
163
158
5.22
59.86
3.1
1.6
37.5
60.3
mg/l
0.51
114
99
1788
5899
1.57
58.19
1.6
1.3
—
—
—
0
0
144
126
5.78
58.10
1.7
1.4
3.5
1.6
nmol/l
0.85
107
99
131
104
6.37
57.38
1.6
1.4
35.1
42.2
g/l
4.61
117
94
211
271
3.94
57.04
1.6
1.3
—
—
—
0
0
370
697
2.70
56.30
1.1
1.1
1.5
1.4
g/l
2.57
334
640
425
862
2.51
56.18
1.5
1.6
0.7
0.8
g/l
1.51
317
679
1232
3736
1.70
55.79
1.1
1.1
—
—
—
0
0
561
1302
2.20
55.37
1.2
1.2
34.8
40.7
u/ml
0.26
45
109
314
544
2.93
55.29
1.5
1.2
—
—
—
0
0
241
357
3.42
53.98
3.4
2.6
1073.4
577.6
u/ml
0.19
229
326
535
1234
2.21
53.59
1.4
1.2
102.5
105.9
u/ml
0.24
103
256
239
354
3.42
53.54
8.0
1.6
7.3
5.8
mmol/l
7.36
201
276
615
1506
2.08
53.22
1.3
1.3
10.0
11.7
u/ml
0.20
89
227
808
2191
1.89
52.79
1.3
1.3
—
—
—
0
0
2768
10182
1.42
52.71
1.8
2.0
—
—
—
0
0
605
1489
2.07
51.68
1.3
1.3
3.5
9.5
u/ml
1.34
43
151
394
806
2.48
51.23
1.2
1.2
—
—
—
0
0
79
34
11.73
50.95
1.4
1.0
—
—
—
0
0
323
598
2.74
50.75
1.1
1.1
36.2
40.8
mg/l
1.01
263
496
224
335
3.39
49.53
1.5
1.4
—
—
—
0
0
224
335
3.39
49.53
1.5
1.4
—
—
—
0
0
150
162
4.68
49.48
2.0
2.8
1.0
0.9
ug/l
0.18
138
157
288
507
2.88
49.42
1.4
1.3
6.4
6.6
g/l
0.37
201
359
224
336
3.38
49.32
1.5
1.4
—
—
—
0
0
224
336
3.38
49.32
1.5
1.4
—
—
—
0
0
98
65
7.61
49.17
3.2
1.8
—
—
—
0
0
287
506
2.88
49.12
1.4
1.3
0.4
0.4
g/l
0.30
197
361
186
244
3.86
49.04
2.8
2.2
55.4
55.1
%
0.05
113
152
287
507
2.87
48.96
1.4
1.3
2.9
3.2
g/l
1.46
198
357
274
476
2.92
48.09
2.3
2.1
—
—
—
0
0
285
508
2.85
47.89
1.4
1.3
—
—
—
0
0
194
269
3.65
47.63
3.1
1.9
—
—
—
0
0
833
2358
1.81
47.62
1.2
1.2
—
—
—
0
0
309
584
2.68
46.81
1.1
1.0
231.5
220.1
mg/l
0.50
267
521
421
928
2.31
46.79
2.1
2.3
—
—
—
0
0
248
416
3.02
46.12
2.4
2.2
1.3
1.2
e9/l
0.07
149
213
67
5
67.61
45.56
5.2
4.0
—
—
—
0
0
6354
26877
1.26
45.39
1.6
1.7
—
—
—
0
0
484
1151
2.14
45.09
1.1
1.0
—
—
—
0
0
81
46
8.89
44.97
4.7
3.3
—
—
—
0
0
468
1102
2.16
44.67
1.2
1.2
9.0
22.3
u/ml
—
6
14
175
238
3.72
44.11
1.5
1.5
5.9
5.1
u/l
0.63
150
215
145
169
4.34
44.07
1.2
1.1
—
—
—
0
0
154
190
4.10
43.82
2.6
2.6
52.3
53.3
umol/l
0.13
135
177
120
118
5.14
43.58
2.3
1.6
19.6
14.9
umol/l
—
20
7
529
1326
2.03
43.11
2.2
2.0
6.4
7.2
titre
0.09
17
47
270
497
2.75
42.94
2.9
2.2
174.0
327.5
u/ml
0.17
252
397
264
480
2.79
42.91
1.3
1.2
—
—
—
0
0
177
248
3.61
42.90
1.2
1.1
—
—
—
0
0
106
93
5.76
42.78
1.6
1.4
—
—
—
0
0
59
20
14.88
42.23
1.7
1.1
—
—
—
0
0
153
195
3.97
41.88
1.8
1.8
1.9
1.9
umol/l
0.32
144
187
186
275
3.42
41.88
2.3
2.9
—
—
—
0
0
113
109
5.24
41.82
1.6
1.4
2651.4
5530.0
e6/l
2.05
78
80
138
163
4.28
41.34
1.9
1.9
27.8
28.4
umol/l
0.27
133
157
229
394
2.94
40.92
1.1
1.1
—
—
—
0
0
134
156
4.34
40.81
1.8
2.0
1.4
1.4
g/24h
0.03
12
25
202
323
3.17
40.55
2.5
3.2
—
—
—
0
0
330
697
2.40
40.27
1.3
1.2
—
—
—
0
0
102
92
5.60
40.19
1.6
1.5
—
—
—
0
0
856
2580
1.70
39.49
1.1
1.1
3.2
6.3
u/ml
2.48
123
462
176
266
3.35
38.45
1.2
1.1
75.6
89.7
%
1.14
18
23
201
334
3.05
38.03
2.0
1.9
74.3
75.1
%
0.31
190
328
1005
3195
1.61
37.81
2.4
1.7
36.5
26.1
u/ml
1.63
974
3087
137
174
3.98
37.71
1.0
1.0
268.9
315.9
ng/l
1.05
95
137
457
1141
2.04
37.68
1.9
1.8
4859.1
3456.0
titre
0.22
23
60
104
104
5.05
37.22
2.3
2.0
9.3
9.0
mmol/l
0.21
77
75
1485
10478
0.69
36.79
1.4
1.3
—
—
—
0
0
135
174
3.92
36.51
1.0
1.0
821.5
709.5
ng/l
1.47
91
127
73
49
7.52
36.40
1.1
1.1
—
—
—
0
0
209
367
2.88
36.15
1.1
1.1
—
—
—
0
0
681
1972
1.76
36.13
9.8
4.0
—
—
—
0
0
83
67
6.25
36.00
3.4
1.9
—
—
—
0
0
74
52
7.18
35.72
1.0
1.0
—
—
—
0
0
195
332
2.97
35.52
2.0
1.9
13.1
13.1
%
0.03
100
181
97
95
5.15
35.44
1.5
1.4
97129.2
56617.8
e6/l
0.31
58
60
93
88
5.33
35.11
4.1
2.2
7.4
7.4
ph
0.25
25
22
721
2145
1.71
34.85
1.1
1.1
—
—
—
0
0
879
2765
1.62
34.49
1.8
1.5
—
—
—
0
0
108
121
4.51
34.39
2.1
1.4
—
—
—
0
0
93
90
5.22
34.38
1.6
1.3
—
—
—
0
0
80
67
6.02
33.68
2.8
1.7
—
—
—
0
0
118
146
4.08
33.58
1.2
1.1
13.8
10.3
%
0.18
13
16
2273
8685
1.35
33.47
1.4
1.3
—
—
—
0
0
90
87
5.22
33.32
1.7
1.4
—
—
—
0
0
59
33
9.02
33.12
2.3
1.5
515.6
1346.3
e6/l
0.66
41
21
165
269
3.10
32.26
1.6
1.4
24.1
26.3
umol/l
0.35
156
262
142
210
3.42
32.09
2.2
1.4
—
—
—
0
0
184
327
2.85
31.26
1.1
1.1
411.0
397.5
nmol/l
0.35
171
313
117
153
3.86
31.15
1.2
1.1
—
—
—
0
0
130
185
3.55
31.00
1.3
1.2
—
—
—
0
0
157
257
3.09
30.53
1.1
1.1
0.9
5.5
nmol/l
0.92
21
53
242
509
2.41
29.93
1.3
1.5
—
—
titre
—
0
0
55
33
8.40
29.59
1.1
1.3
81.3
44.7
ng/l
0.26
23
22
306
719
2.16
29.51
1.3
1.3
69.9
28.1
u/ml
1.14
15
43
109
142
3.88
29.19
1.4
1.2
5.8
5.2
mmol/l
1.44
99
131
100
122
4.14
29.00
2.5
3.0
27.2
27.3
umol/l
0.03
67
103
51
28
9.18
28.97
1.9
1.4
1778.4
15806.1
e6/l
—
27
8
48
24
10.08
28.75
1.8
1.7
—
—
—
0
0
63
48
6.62
28.68
1.1
1.1
—
—
—
0
0
45
20
11.34
28.63
6.6
2.4
—
—
—
0
0
148
244
3.07
28.49
1.5
1.3
—
—
—
0
0
184
348
2.67
28.05
1.4
1.4
73.5
72.3
%
0.56
172
334
182
343
2.68
27.93
2.6
2.3
524.3
507.1
e6/l
0.18
148
277
143
234
3.09
27.87
1.3
1.2
424.0
349.8
u/l
0.21
130
225
204
409
2.52
27.84
1.1
1.1
—
—
—
0
0
36
10
18.14
27.67
5.3
5.9
—
—
—
0
0
180
342
2.66
27.23
1.4
1.4
466.9
506.6
mu/l
0.23
168
328
111
155
3.62
27.21
2.1
1.4
3.7
2.1
mg/l
2.16
101
149
178
338
2.66
26.96
1.1
1.2
1.1
1.1
ratio
0.13
69
110
69
64
5.44
26.63
1.6
1.4
—
—
—
0
0
47
26
9.11
26.60
1.8
1.5
—
—
—
0
0
176
335
2.66
26.55
2.7
2.3
0.2
0.2
e9/l
0.37
147
277
209
435
2.43
26.48
2.3
2.2
46.0
46.9
%
0.10
28
57
51
34
7.56
25.63
1.2
1.1
0.7
0.7
umol/24h
0.03
31
20
86
104
4.17
25.25
22.6
14.7
125.8
127.7
ug/l
0.06
66
89
48
30
8.06
25.19
1.6
1.2
11.8
10.5
g/l
0.23
33
18
1168
4203
1.42
24.44
2.6
2.1
—
—
—
0
0
31
0
+∞
24.20
1.4
0.0
563.9
—
nmol/l
—
31
0
701
2282
1.56
23.92
2.9
2.0
—
—
—
0
0
146
271
2.72
23.13
1.1
1.2
24.7
5.8
u/ml
0.52
18
36
186
392
2.40
23.04
1.1
1.2
—
—
—
0
0
53
43
6.21
23.01
1.5
1.3
—
—
—
0
0
161
316
2.57
23.00
1.2
1.1
—
—
—
0
0
31
10
15.62
22.62
5.4
5.9
—
—
—
0
0
97
142
3.45
22.38
3.6
2.1
—
—
—
0
0
69
78
4.46
21.91
1.1
1.0
80.4
79.7
ug/l
0.04
59
68
174
364
2.42
21.91
2.9
2.5
812.1
884.2
e6/l
0.54
67
146
83
110
3.81
21.87
1.6
1.2
—
—
—
0
0
150
292
2.59
21.79
3.0
1.9
—
—
—
0
0
130
235
2.79
21.61
1.3
1.2
0.3
0.3
g/l
0.40
105
187
142
271
2.65
21.42
1.3
1.4
—
—
—
0
0
194
432
2.27
21.36
1.2
1.3
220.0
257.2
titre
0.19
33
65
39
23
8.54
21.26
2.5
5.6
0.8
0.9
mmol/l
0.17
31
16
410
1198
1.73
21.26
1.4
1.4
—
—
—
0
0
37
20
9.32
21.25
1.9
1.2
6.4
1228576.5
nmol/l
1.02
28
14
85
118
3.63
21.11
1.5
1.3
17.6
15.7
umol/l
2.38
71
108
3177
13398
1.22
20.80
3.1
2.7
21.6
22.3
%
1.45
1016
4670
46
36
6.44
20.58
1.1
1.2
343.7
280.2
pmol/l
0.47
32
28
76
100
3.83
20.24
2.6
1.0
—
—
—
0
0
83
117
3.58
20.21
1.3
1.2
—
—
—
0
0
39
25
7.86
20.16
1.3
1.2
—
—
—
0
0
47
39
6.07
20.06
2.4
3.3
43.5
34.4
mg/l
—
13
10
98
157
3.15
19.88
1.7
1.6
7.4
4.7
mmol/24h
—
9
19
52
49
5.35
19.86
1.7
1.2
—
—
—
0
0
113
198
2.88
19.86
1.2
1.1
4.1
3.5
iu/ml
—
10
22
172
377
2.31
19.66
1.4
1.6
6.3
8.0
ug/l
0.56
149
334
39
26
7.56
19.64
5.3
4.5
46.1
33.4
ug/min
0.23
28
16
130
249
2.64
19.53
2.8
2.9
46.6
42.5
%
1.14
42
75
95
151
3.17
19.51
1.2
1.1
—
—
—
0
0
92
144
3.22
19.34
1.1
1.1
—
—
—
0
0
369
1077
1.74
19.25
1.7
1.7
14480.6
10488.9
e6/l
0.66
260
799
110
195
2.85
18.98
2.0
2.0
26.7
27.7
%
0.41
104
190
177
401
2.23
18.81
2.6
1.7
—
—
—
0
0
265
704
1.90
18.65
1.4
1.4
—
—
—
0
0
231
586
1.99
18.52
1.1
1.1
—
—
—
0
0
469
1476
1.61
18.51
1.1
1.1
10.7
11.9
au/ml
0.16
30
137
38
27
7.09
18.31
2.4
1.2
7.0
5.6
mmol/l
0.69
20
19
50
50
5.04
18.08
1.3
1.5
—
—
—
0
0
56
63
4.48
17.94
2.8
1.9
—
—
—
0
0
242
632
1.94
17.91
1.3
1.3
—
—
—
0
0
1267
8233
0.76
17.82
1.4
1.4
—
—
—
0
0
101
178
2.86
17.63
1.1
1.1
—
—
—
0
0
53
59
4.53
17.19
3.1
1.5
55.3
53.6
%
0.19
53
54
1221
4687
1.33
17.15
1.3
1.3
231.1
232.9
miu/ml
0.06
563
2474
89
148
3.03
17.10
1.9
1.9
—
—
—
0
0
42
37
5.72
17.08
1.1
1.1
—
—
—
0
0
420
3264
0.64
16.89
1.2
1.2
—
—
—
0
0
205
516
2.01
16.83
1.2
1.3
0.8
1.4
u/ml
0.62
77
188
89
151
2.97
16.58
1.3
1.3
97.8
113.7
titre
—
9
19
83
136
3.08
16.35
2.4
1.4
—
—
—
0
0
57
72
3.99
16.04
1.3
1.1
—
—
—
0
0
90
157
2.89
16.03
2.1
2.1
185.7
128.8
e6/l
1.43
51
82
418
1332
1.59
15.75
2.0
1.7
—
—
—
0
0
303
890
1.72
15.57
1.5
1.5
—
—
—
0
0
31
21
7.44
15.47
1.3
1.1
1.8
1.3
umol/24h
2.13
31
21
105
205
2.58
15.33
1.4
1.6
2411.8
1842.1
ml
1.77
19
24
100
191
2.64
15.21
1.1
1.1
—
—
—
0
0
91
165
2.78
15.20
1.3
1.3
1100.0
332.9
titre
—
6
7
82
140
2.95
15.16
1.2
1.1
—
—
—
0
0
35
29
6.08
15.02
1.5
1.2
23.1
20.8
g/l
0.20
25
21
40
39
5.17
14.87
1.3
1.4
249.8
53.9
mu/l
0.61
33
28
287
845
1.72
14.66
3.7
2.2
—
—
—
0
0
252
718
1.77
14.40
1.4
1.6
20.2
34.6
iu/ml
0.90
14
28
44
49
4.52
14.32
1.8
1.7
34.2
25.0
pmol/l
0.27
39
44
769
2827
1.38
14.30
1.1
1.1
2.1
1.9
u/ml
0.16
331
1198
228
632
1.82
14.24
1.1
1.1
—
—
—
0
0
194
511
1.92
14.13
1.9
1.6
23.0
27.0
mg/l
0.41
62
127
78
135
2.91
14.13
1.3
1.1
—
—
—
0
0
699
2535
1.40
14.09
1.1
1.1
6.6
7.1
u/ml
0.30
379
1431
670
2415
1.41
13.99
1.1
1.1
1.6
1.1
u/ml
0.58
291
1102
480
1625
1.50
13.89
1.4
1.4
123.9
55.3
pmol/l
1.34
467
1582
425
1402
1.54
13.86
1.2
1.2
—
—
—
0
0
415
1368
1.54
13.59
1.2
1.2
—
—
—
0
0
65
103
3.18
13.55
1.1
1.2
—
—
—
0
0
102
214
2.40
12.99
1.1
1.1
70.0
264.5
ng/l
0.87
20
39
41
47
4.40
12.96
2.0
1.8
—
—
—
0
0
96
196
2.47
12.92
1.1
1.1
—
—
—
0
0
63
102
3.11
12.74
1.4
1.1
130.7
137.2
nmol/l
0.07
48
79
56
84
3.36
12.67
1.2
1.0
—
—
—
0
0
22
12
9.23
12.59
1.4
1.1
—
—
—
0
0
76
139
2.76
12.59
5.3
1.2
66.4
15781.7
mg/l
2.12
54
62
151
381
2.00
12.46
1.3
1.2
—
—
—
0
0
168
444
1.91
12.20
1.7
1.6
29.5
41.3
%
3.38
97
293
330
1062
1.57
12.06
1.4
1.3
150.4
75.5
pmol/l
0.48
120
182
22
6
18.46
12.05
5.4
6.8
—
—
—
0
0
446
1538
1.47
11.86
1.1
1.1
—
—
—
0
0
149
383
1.96
11.72
1.2
1.2
33.3
17.8
u/ml
—
8
18
1006
6379
0.78
11.61
1.4
1.5
—
—
—
0
0
27
23
5.91
11.36
1.1
1.4
132.1
169.3
ug/l
—
10
8
37
44
4.24
11.27
2.9
1.5
169.0
102.9
u/l
—
10
16
23
9
12.87
11.18
1.1
1.0
—
—
—
0
0
205
597
1.73
11.01
1.0
1.0
—
—
—
0
0
666
2506
1.35
10.80
1.1
1.1
2.8
2.6
u/ml
0.08
170
652
807
5206
0.77
10.73
1.4
1.5
—
—
—
0
0
805
5192
0.77
10.68
1.4
1.5
—
—
—
0
0
4313
19598
1.13
10.53
1.8
1.7
—
—
—
0
0
34
40
4.28
10.50
1.3
1.1
44.8
79.9
%
2.38
17
16
830
5299
0.78
10.16
1.5
1.5
—
—
—
0
0
321
1070
1.52
10.13
1.5
1.3
—
—
—
0
0
316
1054
1.52
9.95
2.4
2.6
—
—
—
0
0
147
400
1.85
9.89
1.1
1.1
12.3
16.0
u/ml
0.37
32
82
91
208
2.21
9.73
1.2
1.2
—
—
—
0
0
288
949
1.53
9.61
1.2
1.3
—
—
—
0
0
22
18
6.15
9.59
2.4
2.0
—
—
—
0
0
84
187
2.26
9.54
1.1
1.0
—
—
—
0
0
151
422
1.81
9.38
1.1
1.0
—
—
—
0
0
36
49
3.70
9.37
2.9
2.0
—
—
—
0
0
171
498
1.73
9.27
1.7
1.3
6.3
5.3
mmol/l
4.35
129
397
39
57
3.45
9.25
1.7
1.6
—
—
—
0
0
249
1894
0.66
9.23
1.6
1.6
7.8
7.2
mmol/l
2.88
143
1081
92
217
2.14
9.16
2.1
2.3
—
—
—
0
0
68
140
2.45
9.14
1.3
1.2
—
—
—
0
0
256
835
1.55
8.97
1.6
1.4
—
—
—
0
0
114
299
1.92
8.61
2.0
1.3
27.5
724.1
ug/l
1.27
102
286
105
268
1.98
8.56
1.2
1.2
—
—
—
0
0
199
622
1.62
8.36
1.7
1.6
62.5
47.5
%
5.29
114
439
567
2170
1.32
8.31
1.1
1.1
4.7
5.1
u/ml
0.14
225
887
25
29
4.34
7.90
1.1
1.0
—
—
—
0
0
68
151
2.27
7.85
1.4
1.3
—
—
—
0
0
154
458
1.70
7.84
1.5
1.2
68.1
72.3
umol/l
0.36
13
72
34
51
3.36
7.82
1.0
1.1
—
—
—
0
0
155
463
1.69
7.77
1.6
1.3
—
—
—
0
0
41
71
2.91
7.60
1.1
1.1
—
—
—
0
0
31
45
3.47
7.48
1.1
1.2
—
—
—
0
0
104
281
1.87
7.28
1.6
1.4
2.6
3.6
u/field
0.36
77
207
48
94
2.57
7.20
1.2
1.1
—
—
—
0
0
48
94
2.57
7.20
1.2
1.1
—
—
—
0
0
48
94
2.57
7.20
1.2
1.1
—
—
—
0
0
141
421
1.69
7.12
1.4
1.4
43379.9
39062.2
e6/l
0.07
105
280
15
11
6.86
7.11
1.0
1.0
—
—
—
0
0
151
460
1.66
7.09
1.1
1.0
1544.3
1372.9
miu/ml
1.02
151
460
25
32
3.93
7.08
1.1
1.1
22.0
20.5
mmol/l
0.85
15
27
94
248
1.91
7.07
1.6
1.5
5.2
5.8
%
0.09
23
64
457
1743
1.33
6.94
1.1
1.0
0.8
0.5
u/ml
0.26
100
331
117
335
1.76
6.85
1.1
1.1
2.7
16.2
u/ml
1.22
69
210
18
18
5.03
6.63
3.2
1.5
—
—
—
0
0
17
16
5.35
6.61
1.3
1.1
18.3
6.0
%
—
12
10
516
2016
1.29
6.61
1.1
1.1
8.1
5.6
u/ml
0.90
217
873
186
608
1.54
6.59
1.2
1.2
—
—
—
0
0
38
69
2.77
6.56
1.1
1.1
—
—
—
0
0
2251
10107
1.13
6.48
2.4
2.2
0.6
0.7
ug/l
2.93
1247
4631
29
45
3.25
6.41
2.2
1.8
—
—
—
0
0
14
11
6.41
6.31
1.4
1.1
0.1
0.0
%
—
9
5
18
19
4.77
6.30
1.3
1.1
40.5
20.4
%
0.68
13
11
18
19
4.77
6.30
3.4
1.5
—
—
—
0
0
36
67
2.71
5.98
1.9
1.6
2.3
1.6
ug/l
0.65
16
47
16
16
5.03
5.90
1.1
1.0
—
—
—
0
0
15
14
5.39
5.89
1.5
2.6
31.7
44.9
umol/l
1.64
15
14
51
115
2.23
5.80
1.5
1.3
42.3
51.8
%
0.87
43
100
14
9
7.83
5.67
2.0
1.1
—
—
—
0
0
22
31
3.57
5.58
1.1
1.3
—
—
—
0
0
28
47
3.00
5.54
1.1
1.1
—
—
—
0
0
19
24
3.99
5.51
1.1
1.1
—
—
—
0
0
21
29
3.65
5.47
1.0
1.1
0.6
1.8
umol/24h
—
11
10
13
8
8.18
5.42
1.0
1.1
—
—
—
0
0
116
358
1.63
5.30
1.8
1.6
2.3
2.1
u/field
0.15
66
182
11
5
11.07
5.30
1.0
1.0
2.2
—
mpas
—
5
0
308
2044
0.75
5.28
1.5
1.5
—
—
—
0
0
23
35
3.31
5.27
1.2
1.2
—
—
—
0
0
419
1645
1.29
5.27
1.0
1.1
2.7
3.2
u/ml
0.31
215
1011
15
16
4.72
5.21
1.1
1.0
—
—
—
0
0
18
23
3.94
5.16
1.2
1.0
23.5
2.2
%
—
6
5
217
773
1.42
5.15
1.1
1.1
—
—
—
0
0
22
33
3.36
5.15
1.1
1.1
—
—
—
0
0
35
70
2.52
5.14
3.3
1.6
—
—
—
0
0
168
571
1.48
5.09
1.1
1.1
6.9
7.0
iu/ml
0.00
35
183
60
154
1.96
5.00
2.9
1.5
172.6
111.5
ng/l
0.45
38
103
13
13
5.03
4.80
1.0
1.0
—
—
—
0
0
156
531
1.48
4.72
1.3
1.2
—
—
—
0
0
31
61
2.56
4.72
1.2
1.1
—
—
—
0
0
6
0
+∞
4.68
5.0
0.0
—
—
—
0
0
10
5
10.06
4.68
1.4
3.0
3.8
2.4
mu/l
—
10
5
36
79
2.29
4.43
1.0
1.0
29.4
18.5
u/ml
0.31
26
68
19
29
3.30
4.37
1.4
1.4
—
—
—
0
0
88
268
1.65
4.32
1.8
1.3
—
—
—
0
0
71
204
1.75
4.28
1.1
1.0
—
—
—
0
0
16
22
3.66
4.22
1.0
1.0
0.2
0.0
u/ml
—
9
10
71
205
1.74
4.21
1.1
1.0
—
—
—
0
0
71
205
1.74
4.21
1.1
1.0
—
—
—
0
0
45
112
2.02
4.14
1.4
1.1
—
—
—
0
0
27
54
2.52
4.03
1.1
1.2
—
—
—
0
0
26
51
2.57
4.02
1.0
1.0
—
—
—
0
0
63
179
1.77
3.97
1.1
1.2
15.5
11.8
u/ml
0.11
15
50
129
440
1.48
3.94
1.0
1.0
10.6
12.5
u/ml
0.14
17
61
48
125
1.93
3.93
1.1
1.0
—
—
—
0
0
5
0
+∞
3.90
5.4
0.0
1.1
—
g/l
—
5
0
27
55
2.47
3.90
1.1
1.2
—
—
—
0
0
15
21
3.60
3.88
3.7
1.1
—
—
—
0
0
40
98
2.06
3.85
1.3
1.2
38.8
43.6
g/l
1.54
22
55
14
19
3.71
3.77
1.0
1.1
0.2
0.0
u/ml
—
7
6
19
33
2.90
3.64
1.2
1.3
5.1
7.0
mmol/l
—
9
17
17
28
3.06
3.54
1.0
1.0
10.7
9.3
u/ml
0.08
12
22
522
2204
1.20
3.52
1.1
1.1
—
—
—
0
0
8
5
8.05
3.48
1.7
1.2
219.4
197.6
umol/l
—
8
5
521
2205
1.19
3.44
1.1
1.1
—
—
—
0
0
527
2234
1.19
3.42
2.0
2.4
4.9
5.4
umol/l
0.49
375
1661
12
16
3.77
3.31
1.1
1.0
—
—
—
0
0
12
16
3.77
3.31
1.0
1.1
—
—
—
0
0
96
322
1.50
3.25
1.1
1.1
—
—
—
0
0
99
335
1.49
3.22
1.1
1.0
—
—
—
0
0
13
19
3.44
3.20
1.6
1.3
2.2
2.8
mmol/l
—
8
12
9
8
5.66
3.20
2.0
1.6
62.7
59.5
%
—
9
8
36
92
1.97
3.16
1.8
1.6
—
—
—
0
0
25
56
2.25
3.03
1.0
1.2
—
—
—
0
0
76
247
1.55
3.00
1.1
1.1
1.6
10.9
u/ml
1.50
54
175
401
1694
1.19
2.78
1.8
1.7
—
—
—
0
0
29
72
2.03
2.78
1.5
1.5
—
—
—
0
0
41
117
1.76
2.66
1.5
1.4
—
—
—
0
0
15
28
2.70
2.60
1.0
1.0
—
—
—
0
0
46
137
1.69
2.59
1.0
1.0
—
—
—
0
0
209
833
1.26
2.55
1.1
1.0
0.6
1.3
u/ml
0.41
34
105
24
58
2.08
2.49
1.5
1.3
94.5
77.6
ng/l
0.36
24
58
8
9
4.47
2.47
1.1
1.0
—
—
—
0
0
16
32
2.52
2.47
1.2
1.1
—
—
—
0
0
31
83
1.88
2.46
1.0
1.0
1.0
0.7
u/ml
0.18
11
54
9
12
3.77
2.39
5.1
3.5
—
—
—
0
0
346
1467
1.19
2.37
3.5
2.3
21.9
26.0
mg/l
1.27
183
876
16
33
2.44
2.34
1.2
1.1
—
—
—
0
0
37
107
1.74
2.33
1.0
1.0
0.3
1.4
u/ml
0.59
16
71
557
2456
1.14
2.32
1.3
1.2
3.5
3.5
ug/l
0.04
519
2353
215
873
1.24
2.28
1.1
1.0
4.2
2.0
u/ml
0.41
58
202
93
336
1.39
2.26
1.8
1.7
107.6
141.1
au/ml
0.30
15
33
28
75
1.88
2.24
1.1
1.4
—
—
—
0
0
211
858
1.24
2.22
1.1
1.1
5.3
4.6
u/ml
0.07
63
223
19
44
2.17
2.20
1.7
1.4
—
—
—
0
0
7
8
4.40
2.19
1.1
1.1
—
—
—
0
0
93
340
1.38
2.13
2.2
2.0
—
—
—
0
0
6
6
5.03
2.11
1.3
3.3
4.5
4.2
mmol/l
—
6
6
100
670
0.75
2.08
1.2
1.2
—
—
—
0
0
40
123
1.64
2.07
1.5
1.4
26.1
44.3
%
2.82
27
95
93
628
0.74
2.05
6.4
6.6
—
—
—
0
0
93
628
0.74
2.05
3.2
3.3
—
—
—
0
0
111
422
1.32
2.01
2.3
2.0
8.5
10.4
mg/l
2.66
89
346
54
181
1.50
1.97
2.0
2.2
2.0
2.8
ug/l
0.79
44
159
8
12
3.36
1.96
1.5
1.2
91.5
70.3
mg/l
—
8
12
55
186
1.49
1.93
2.0
2.1
2.4
3.0
ug/l
0.46
47
170
5
5
5.03
1.82
1.0
1.0
—
—
—
0
0
5
5
5.03
1.82
1.0
1.0
—
—
—
0
0
20
52
1.94
1.78
1.1
1.1
—
—
—
0
0
12
25
2.42
1.75
2.2
1.4
—
—
—
0
0
71
258
1.39
1.75
1.7
1.7
—
—
—
0
0
6
8
3.77
1.73
1.2
1.0
—
—
—
0
0
35
110
1.60
1.71
1.3
1.2
—
—
—
0
0
36
114
1.59
1.71
1.6
2.8
2.3
2.9
mmol/l
0.92
31
106
39
126
1.56
1.71
1.0
1.0
0.1
2.3
u/ml
1.49
30
99
124
495
1.26
1.62
2.6
2.9
192.8
107.3
au/ml
0.59
15
54
14
33
2.14
1.60
1.0
1.1
—
—
—
0
0
6
9
3.35
1.57
1.2
1.0
128.5
124.9
mmol/24h
—
6
9
7
12
2.94
1.56
1.0
1.2
—
—
—
0
0
12
27
2.24
1.52
1.1
1.0
0.2
0.2
u/ml
—
7
16
19
52
1.84
1.50
1.2
1.3
15.8
14.9
nmol/l
—
5
14
9
18
2.52
1.48
1.0
1.1
—
—
—
0
0
31
99
1.58
1.46
1.0
1.1
10.5
11.1
u/ml
0.05
24
69
5
7
3.59
1.45
1.0
1.0
—
—
—
0
0
6
10
3.02
1.43
1.0
1.0
—
—
—
0
0
148
613
1.22
1.43
1.2
1.1
—
—
—
0
0
16
42
1.92
1.42
1.8
1.4
—
—
—
0
0
80
308
1.31
1.42
2.1
2.0
—
—
—
0
0
133
546
1.23
1.41
3.1
3.6
8.4
8.7
mg/l
0.24
103
449
11
25
2.21
1.37
4.1
6.2
0.2
0.2
mmol/l
0.01
11
25
24
73
1.65
1.37
1.0
1.2
30.8
29.7
u/ml
—
5
13
24
73
1.65
1.37
1.0
1.2
25.8
15.4
u/ml
—
6
14
36
122
1.49
1.33
7.3
2.9
—
—
—
0
0
8
16
2.52
1.32
1.1
1.1
—
—
—
0
0
27
86
1.58
1.31
1.0
1.0
0.2
2.0
u/ml
0.53
12
34
235
1029
1.15
1.23
1.4
1.5
12.8
7.6
mmol/l
4.46
62
17
23
72
1.61
1.20
1.1
1.1
0.3
25.9
u/ml
0.49
11
34
5
9
2.80
1.17
1.4
1.0
—
—
—
0
0
40
143
1.41
1.16
1.0
1.0
0.2
0.9
u/ml
0.86
23
71
19
57
1.68
1.16
1.0
1.1
3.3
1.9
u/ml
0.20
11
41
22
69
1.60
1.15
1.0
1.1
—
—
—
0
0
10
24
2.10
1.13
3.4
1.5
—
—
—
0
0
3397
16571
1.04
1.11
1.5
1.4
—
—
—
0
0
9
21
2.16
1.10
1.0
1.1
—
—
—
0
0
40
146
1.38
1.06
1.0
1.0
0.0
8.6
u/ml
1.09
21
68
6
12
2.52
0.99
1.0
1.0
5.3
14.9
u/ml
—
6
12
9
24
1.89
0.99
1.2
1.0
—
—
—
0
0
106
633
0.84
0.95
2.7
3.1
—
—
—
0
0
365
2010
0.91
0.94
2.6
1.7
13.1
13.0
%
1.25
360
1978
6
14
2.16
0.90
1.0
1.1
—
—
—
0
0
137
796
0.87
0.89
1.2
1.2
1.4
1.5
g/l
0.41
13
23
20
67
1.50
0.84
1.1
1.1
1.3
20.7
u/ml
0.45
14
35
13
39
1.68
0.83
1.2
1.1
—
—
—
0
0
7736
38372
1.02
0.78
2.5
1.8
—
—
—
0
0
33
124
1.34
0.78
1.9
1.8
1.4
1.7
mg/l
0.84
28
102
15
48
1.57
0.77
1.3
1.0
—
—
—
0
0
197
1104
0.90
0.76
1.4
1.3
28.7
34.2
nmol/l
1.77
171
1047
7
19
1.85
0.74
1.0
1.1
31.1
31.5
%
—
7
19
5
12
2.10
0.74
1.2
1.1
1.9
2.0
mmol/24h
—
5
12
345
1608
1.08
0.69
1.4
1.5
7.0
6.2
mmol/l
4.11
248
1118
36
141
1.29
0.67
1.0
1.0
0.9
0.5
u/ml
0.18
19
76
8
23
1.75
0.65
1.0
1.0
—
—
—
0
0
11
34
1.63
0.65
1.0
1.0
—
—
—
0
0
8
25
1.61
0.62
1.0
1.0
—
—
—
0
0
14
48
1.47
0.57
1.1
1.1
—
—
—
0
0
15
53
1.42
0.53
2.3
2.5
6.9
7.3
ug/l
—
6
16
140
636
1.11
0.53
1.0
1.0
—
—
—
0
0
28
111
1.27
0.51
4.1
2.9
19.3
23.4
mg/l
0.73
28
106
7
23
1.53
0.49
1.0
1.0
65.5
66.2
%
—
7
23
48
206
1.17
0.44
1.1
1.1
—
—
—
0
0
60
344
0.88
0.41
1.2
1.2
—
—
—
0
0
0
10
0.00
0.41
0.0
1.4
—
—
—
0
0
14
52
1.35
0.40
1.8
1.2
298.8
299.2
umol/24h
0.00
14
52
9
33
1.37
0.39
1.4
1.2
—
—
—
0
0
54
244
1.11
0.28
1.6
1.3
—
—
—
0
0
0
6
0.00
0.22
0.0
1.0
—
—
—
0
0
8
49
0.82
0.14
10.4
6.6
—
—
—
0
0
22
99
1.12
0.14
1.3
1.5
0.5
0.3
umol/l
—
6
39
37
172
1.08
0.14
1.3
1.2
—
—
—
0
0
132
645
1.03
0.10
1.2
1.3
—
—
—
0
0
28
131
1.08
0.09
3.0
2.7
—
—
—
0
0
112
577
0.98
0.07
1.2
1.4
—
—
—
0
0
16
87
0.93
0.06
1.1
1.1
—
—
—
0
0
126
622
1.02
0.05
1.4
1.5
5.6
5.0
mmol/l
7.13
116
599
14
70
1.01
0.00
2.3
1.7
0.6
0.8
u/field
0.43
14
70
5
27
0.93
0.00
1.0
1.0
0.6
0.9
u/ml
—
5
22
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint ANTIDEPRESSANTS and mortality.

Females

Parameter HR [95% CI] p-value
ANTIDEPRESSANTS 1.488 [1.39, 1.6] < 0.001
Birth year 0.991 [0.98, 1.0] 0.031

During the follow-up period (1.1.1998 — 31.12.2019), 103249 out of 611724 females with ANTIDEPRESSANTS died.

Males

Parameter HR [95% CI] p-value
ANTIDEPRESSANTS 1.798 [1.66, 1.95] < 0.001
Birth year 0.981 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 79482 out of 387224 males with ANTIDEPRESSANTS died.

Mortality risk

Mortality risk for people of age

years, who have ANTIDEPRESSANTS.

N-year risk Females Males
1 0.079% 0.249%
5 0.594% 1.465%
10 1.431% 3.877%
15 2.817% 7.036%
20 5.127% 11.528%

Relationships between endpoints

Index endpoint: ANTIDEPRESSANTS – Depression medications

GWS hits: 52

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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