No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
154737 |
6. Filter based on genotype QC (FinnGen only) |
154737 |
Control definitions (FinnGen only)
- Control exclude
- NEURO_COMORBIDITIES
Extra metadata
- First used in FinnGen datafreeze
- DF2
Depression medications
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1301037 | 797631 | 495459 |
| Only index persons | 1186033 | 738521 | 447512 |
| Unadjusted period prevalence (%) | |||
| Whole population | 19.33 | 22.85 | 13.84 |
| Only index persons | 23.35 | 27.15 | 17.08 |
| Median age at first event (years) | |||
| Whole population | 45.17 | 45.51 | 44.51 |
| Only index persons | 43.34 | 43.69 | 42.76 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 154737 | 101483 | 53254 |
| Unadjusted period prevalence (%) | 30.77 | 34.59 | 23.48 |
| Median age at first event (years) | 44.49 | 42.23 | 48.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 170
- Matched controls
- 1350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N05AH04
ATC
quetiapine; oral
445.8
67.5
68
*
N06AB03
ATC
fluoxetine; oral
801.2
64.5
64
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
152.0
63.9
69
6
N06AB10
ATC
escitalopram; oral
157.3
58.3
63
5
N06AB06
ATC
sertraline; oral
337.2
55.2
57
*
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
118.4
52.9
59
6
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
29.0
49.7
73
34
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
151.4
48.5
53
*
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
117.9
46.4
52
5
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
45.8
44.9
58
15
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
124.0
41.2
46
*
IGP01
NOMESCO Finland
Psychiatric family contact
199.3
36.1
39
*
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
192.7
35.1
38
*
IGY99
NOMESCO Finland
Other psychiatric treatment contact
132.8
35.0
39
*
IGY02
NOMESCO Finland
Psychiatric monitoring contact
99.6
34.0
39
*
IFA01
NOMESCO Finland
Psychiatric pharmacotherapy plan, not specified
+∞
32.7
33
*
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
337.8
32.2
34
*
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
119.9
32.0
36
*
N05AX08
ATC
risperidone; systemic
56.7
31.5
39
7
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
325.1
31.2
33
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
312.6
30.2
32
*
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
30.2
29.0
41
14
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
62.0
26.2
32
5
F90.0
ICD-10 Finland
Disturbance of activity and attention
16.8
24.0
41
25
P01
ICPC
Feeling anxious/nervous/tense
8.8
23.1
56
71
IGV01
NOMESCO Finland
Psychiatric network contact
121.0
23.0
26
*
N05AX12
ATC
aripiprazole; systemic
115.5
22.0
25
*
F93.89
ICD-10 Finland
Other childhood emotional disorders
115.5
22.0
25
*
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
+∞
21.5
22
*
N06AX26
ATC
vortioxetine; oral
+∞
21.5
22
*
N06AX16
ATC
venlafaxine; oral
209.7
21.1
23
*
N05BA04
ATC
oxazepam; oral
110.1
21.1
24
*
SPAT1389
SPAT
Visit based on need for special support
7.3
20.0
55
83
N06BA04
ATC
methylphenidate; oral
14.9
19.7
35
23
SPAT1307
SPAT
Psychosocial counselling and guidance
7.5
19.4
52
75
P76
ICPC
Depressive disorder
38.5
18.9
25
6
IDY03
NOMESCO Finland
Systematic individual therapy, cognitive-behavioural
+∞
18.5
19
*
IEP03
NOMESCO Finland
Focused parental counselling
49.7
17.5
22
*
N06AX11
ATC
mirtazapine; oral
62.8
17.3
21
*
N06AX12
ATC
bupropion; oral
89.4
17.2
20
*
P03
ICPC
Feeling depressed
9.4
17.1
38
40
IEP99
NOMESCO Finland
Other psychiatric family intervention
56.2
15.4
19
*
N05AH03
ATC
olanzapine; systemic
79.4
15.3
18
*
IEV99
NOMESCO Finland
Other psychiatric network intervention
149.0
15.3
17
*
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
+∞
14.5
15
*
F32.1
ICD-10 Finland
Moderate depressive episode
74.5
14.3
17
*
C07AA05
ATC
propranolol; systemic
14.6
13.7
24
15
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
+∞
13.5
14
*
SPAT1240
SPAT
Therapeutic discussion
7.7
13.3
33
41
P74
ICPC
Anxiety disorder/anxiety state
17.1
12.8
21
11
F93.9
ICD-10 Finland
Childhood emotional disorder, unspecified
+∞
12.6
13
*
IFA99
NOMESCO Finland
Other psychiatric pharmacotherapy service
+∞
12.6
13
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
+∞
12.6
13
*
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
21.0
12.5
19
8
F84.5
ICD-10 Finland
Asperger syndrome
22.6
12.1
18
7
F32
ICD-10 Finland
Depressive episode
34.8
12.0
16
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
19.8
11.6
18
8
IBA02
NOMESCO Finland
Evaluation of need for psychiatric rehabilitation
55.5
10.6
13
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
+∞
10.6
11
*
R5599
NOMESCO Finland
Other rehabilitation service
25.9
10.5
15
5
F98.8
ICD-10 Finland
Other specified behavioural and emotional disorders with onset usually occurring in childhood and adolescence
101.9
10.5
12
*
F40.1
ICD-10 Finland
Social phobias
30.1
10.2
14
*
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
14.8
10.0
17
10
F41.1
ICD-10 Finland
Generalized anxiety disorder
37.0
9.9
13
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
50.9
9.7
12
*
F92.9
ICD-10 Finland
Mixed disorder of conduct and emotions, unspecified
+∞
9.6
10
*
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
18.5
9.6
15
7
N06AB04
ATC
citalopram; systemic
92.8
9.6
11
*
IEP01
NOMESCO Finland
Psychoeducation, family
92.8
9.6
11
*
IBZ06
NOMESCO Finland
Evaluation concerning developmental neuropsychiatry
92.8
9.6
11
*
IEP02
NOMESCO Finland
Child-centred family therapy
33.9
9.0
12
*
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
46.4
8.8
11
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.6
8.7
26
42
F41.00
ICD-10 Finland
Moderate panic disorder
+∞
8.6
9
*
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
+∞
8.6
9
*
F34.1
ICD-10 Finland
Dysthymia
+∞
8.6
9
*
331
Kela drug reimbursment
Atomoxetine, dexamphetamine, guanfacine and lisdexamphetamine
25.4
8.5
12
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.6
8.4
25
40
Z07
ICPC
Education problem
9.9
8.4
17
15
N03AX09
ATC
lamotrigine; oral
20.3
8.0
12
5
F90.9
ICD-10 Finland
Hyperkinetic disorder, unspecified
41.9
7.9
10
*
P06
ICPC
Sleep disturbance
7.2
7.8
19
23
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.7
7.7
27
52
N02BE01
ATC
paracetamol; systemic, rectal
2.6
7.7
77
325
H03AA01
ATC
levothyroxine sodium; systemic
75.0
7.7
9
*
N06AX21
ATC
duloxetine; oral
75.0
7.7
9
*
F93.80
ICD-10 Finland
Generalized anxiety in the bardom age
+∞
7.7
8
*
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
+∞
7.7
8
*
IAB07
NOMESCO Finland
Consultation concerning a patient with self-harm intention
+∞
7.7
8
*
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
+∞
7.7
8
*
Z71.8
ICD-10 Finland
Other specified counselling
3.1
7.2
45
140
D01
ICPC
Abdominal pain/cramps general
3.0
7.2
48
157
F41.8
ICD-10 Finland
Other specified anxiety disorders
37.5
7.0
9
*
C07AB07
ATC
bisoprolol; oral
8.6
7.0
15
15
F51.0
ICD-10 Finland
Nonorganic insomnia
7.7
7.0
16
18
T36
ICD-10 Finland
Poisoning by systemic antibiotics
15.4
6.8
11
6
F39
ICD-10 Finland
Unspecified mood [affective] disorder
+∞
6.7
7
*
IER05
NOMESCO Finland
Rehabilitative psychiatric group intervention, social skills
+∞
6.7
7
*
F95.2
ICD-10 Finland
Combined vocal and multiple motor tic disorder [de la Tourette]
+∞
6.7
7
*
IAB03
NOMESCO Finland
Neuropsychiatric consultation
+∞
6.7
7
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
+∞
6.7
7
*
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
+∞
6.7
7
*
ICC01
NOMESCO Finland
Psychiatric treatment plan, transfer to psychiatric outpatient clinic
+∞
6.7
7
*
R51.80
ICD-10 Finland
Headache
3.5
6.7
32
83
N03AX16
ATC
pregabalin; oral
10.0
6.6
13
11
K30
ICD-10 Finland
Functional dyspepsia
11.3
6.5
12
9
R4190
NOMESCO Finland
Nutritional therapy
5.2
6.5
20
34
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.1
6.4
38
113
F41.09
ICD-10 Finland
UNS Panic Syndrome
25.0
6.4
9
*
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
25.0
6.4
9
*
M03BX02
ATC
tizanidine; oral
6.1
6.4
17
24
D11
ICPC
Diarrhoea
3.5
6.1
29
75
Mortality – FinRegistry
↥Association
Association between endpoint ANTIDEPRESSANTS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ANTIDEPRESSANTS | 1.488 [1.39, 1.6] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 103249 out of 611724 females with ANTIDEPRESSANTS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ANTIDEPRESSANTS | 1.798 [1.66, 1.95] | < 0.001 |
| Birth year | 0.981 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 79482 out of 387224 males with ANTIDEPRESSANTS died.
Mortality risk
Mortality risk for people of age
years, who have ANTIDEPRESSANTS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.079% | 0.249% |
| 5 | 0.594% | 1.465% |
| 10 | 1.431% | 3.877% |
| 15 | 2.817% | 7.036% |
| 20 | 5.127% | 11.528% |
Relationships between endpoints
↥Index endpoint: ANTIDEPRESSANTS – Depression medications
GWS hits: 52
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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