brain neoplasm: A neoplasm (disease) that involves the brain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
5233 |
4. Check minimum number of eventsNone |
5233 |
5. Include endpointsNone |
5233 |
6. Filter based on genotype QC (FinnGen only) |
5088 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D22
- Name in latin
- Naevus melanocyticus (cutis) trunci
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 29275 | 16097 | 13097 |
| Only index persons | 27901 | 15497 | 12404 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.42 | 0.46 | 0.37 |
| Only index persons | 0.53 | 0.57 | 0.47 |
| Median age at first event (years) | |||
| Whole population | 44.81 | 41.41 | 49.03 |
| Only index persons | 45.35 | 41.84 | 49.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5088 | 2988 | 2100 |
| Unadjusted period prevalence (%) | 1.02 | 1.06 | 0.96 |
| Median age at first event (years) | 52.17 | 45.74 | 61.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 5233
- Matched controls
- 52330
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_MELANOCYTIC_TRUNK and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_TRUNK | 0.926 [0.8, 1.07] | 0.288 |
| Birth year | 0.996 [0.99, 1.0] | 0.388 |
During the follow-up period (1.1.1998 — 31.12.2019), 609 out of 12216 females with CD2_BENIGN_MELANOCYTIC_TRUNK died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MELANOCYTIC_TRUNK | 1.086 [0.94, 1.25] | 0.248 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1132 out of 10088 males with CD2_BENIGN_MELANOCYTIC_TRUNK died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_MELANOCYTIC_TRUNK.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.11% | 0.207% |
| 5 | 0.616% | 1.207% |
| 10 | 1.534% | 3.084% |
| 15 | 2.884% | 5.662% |
| 20 | 5.105% | 9.699% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_MELANOCYTIC_TRUNK – Melanocytic naevi of trunk
GWS hits: 11