Atrial fibrillation and flutter

I9_AF

atrial fibrillation: A disorder characterized by an electrocardiographic finding of a supraventricular arrhythmia characterized by the replacement of consistent P waves by rapid oscillations or fibrillatory waves that vary in size, shape and timing and are accompanied by an irregular ventricular response. (CDISC)

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 I48
Hospital discharge: ICD-9 4273
Hospital discharge: ICD-8 42792
Cause of death: ICD-10 I48
Cause of death: ICD-9 4273
Cause of death: ICD-8 42792
KELA reimbursements: KELA codes 207|351
KELA reimbursements: ICD-10 I48

36412

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

35791

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Check minimum number of events None

35791

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Include endpoints

35791

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I9_AF

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I30-I52
Name in latin Fibrillatio atriorum

Summary Statistics

Key figures

All Female Male
Number of individuals 34748 13256 21492
Unadjusted prevalence (%) 11.26 7.64 15.92
Mean age at first event (years) 67.31 69.39 66.02

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.98 [2.67, 3.33] 5.5e-83 7723
15 years 0.01 1.55 [1.39, 1.72] 1.9e-15 2907
5 years 0.00 3.40 [3.12, 3.71] <1e-100 2647
1 year - - - -

Correlations

Index endpoint: I9_AF – Atrial fibrillation and flutter
GWS hits: 54

Survival analyses between endpoints

Plot

before Atrial fibrillation and flutter
after Atrial fibrillation and flutter

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Atrial fibrillation and flutter