Dental caries 3 and operation codes, only avohilmo

K11_CARIES_3_OPER_ONLYAVO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • K11_DENTAL_OPER_ONLYAVO
278821

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

199201

6. Filter based on genotype QC (FinnGen only)

199201

Control definitions (FinnGen only)

Control conditions
K11_DENTAL_OPER

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1816427 964972 842425
Only index persons 1727776 926280 801496
Unadjusted period prevalence (%)
Whole population 25.65 27.64 23.54
Only index persons 32.45 34.05 30.60
Median age at first event (years)
Whole population 37.11 38.09 36.04
Only index persons 38.75 39.53 37.85

-FinnGen-

Key figures

All Female Male
Number of individuals 199201 123837 75364
Unadjusted period prevalence (%) 38.81 42.21 33.22
Median age at first event (years) 51.11 48.34 55.67

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

Mortality – FinRegistry

Association

Association between endpoint K11_CARIES_3_OPER_ONLYAVO and mortality.

Females

Parameter HR [95% CI] p-value
K11_CARIES_3_OPER_ONLYAVO 0.773 [0.65, 0.92] 0.003
Birth year 0.996 [0.99, 1.0] 0.272

During the follow-up period (1.1.1998 — 31.12.2019), 16544 out of 868402 females with K11_CARIES_3_OPER_ONLYAVO died.

Males

Parameter HR [95% CI] p-value
K11_CARIES_3_OPER_ONLYAVO 0.731 [0.61, 0.87] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 20723 out of 752181 males with K11_CARIES_3_OPER_ONLYAVO died.

Mortality risk

Mortality risk for people of age

years, who have K11_CARIES_3_OPER_ONLYAVO.

N-year risk Females Males
1 0.051% 0.12%
5 0.365% 0.781%
10 0.998% 2.064%
15 2.072% 4.031%
20 3.689% 6.841%

Relationships between endpoints

Index endpoint: K11_CARIES_3_OPER_ONLYAVO – Dental caries 3 and operation codes, only avohilmo

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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