Dental caries 3 and operation codes, only avohilmo

K11_CARIES_3_OPER_ONLYAVO

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • K11_DENTAL_OPER_ONLYAVO
278821

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

199201

6. Filter based on genotype QC (FinnGen only)

199201

Control definitions (FinnGen only)

Control conditions
K11_DENTAL_OPER

Extra metadata

First used in FinnGen datafreeze
DF7

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1816427 964972 842425
Only index persons 1727776 926280 801496
Unadjusted period prevalence (%)
Whole population 25.65 27.64 23.54
Only index persons 32.45 34.05 30.60
Median age at first event (years)
Whole population 37.11 38.09 36.04
Only index persons 38.75 39.53 37.85

-FinnGen-

Key figures

All Female Male
Number of individuals 199201 123837 75364
Unadjusted period prevalence (%) 38.81 42.21 33.22
Median age at first event (years) 51.11 48.34 55.67

-FinRegistry-

Age distribution of first events

01020304050607080900k20k40k60k80k100k120k140k160k180k200k220k240k260k280k300kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900k5k10k15k20k25k30k35kAgeIndividuals

-FinRegistry-

Year distribution of first events

197019752015202020220k100k200k300k400k500k600k700k800kYearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199019952000200520102015202020230k10k20k30k40k50k60k70k80k90kYearIndividuals

-FinRegistry-

Cumulative Incidence Function

010203040506070809010001020304050607080AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

010203040506070809010001020304050607080AgeProbability of first incidence (%)

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
14953
71085
1.32
39.26
5.0
4.7
2.00
2.17
mu/l
0.61
13924
66415
16021
77042
1.38
37.77
15.4
15.9
3.95
3.95
mmol/l
0.63
15629
75057
15980
76852
1.37
37.01
15.2
15.8
139.61
139.61
mmol/l
0.13
15617
75001
219
2569
0.42
35.39
4.1
4.0
—
—
—
0
0
13976
66309
1.25
31.78
5.5
5.2
39.20
38.63
mmol/mol
9.84
13053
62269
166
2070
0.40
31.19
2.9
3.4
7.03
7.39
mmol/l
1.18
159
2038
14983
71775
1.28
30.34
4.4
4.2
5.85
5.77
mmol/l
11.50
13839
66748
190
2156
0.44
28.20
2.7
3.4
1.53
1.51
mmol/l
0.09
180
2118
16655
81159
1.37
27.14
15.4
15.8
74.25
75.80
umol/l
7.82
16649
81115
12086
56809
1.21
26.86
7.3
8.0
77.46
77.76
u/l
0.25
11388
53877
7144
32143
1.19
25.11
5.9
7.4
1.21
1.21
mmol/l
0.60
6518
29419
17673
87256
1.64
24.18
20.5
20.3
256.06
253.70
e9/l
5.09
17307
85296
12887
61163
1.20
24.08
4.2
4.0
14.64
14.67
pmol/l
0.73
11838
56171
17682
87335
1.64
23.58
20.5
20.3
4.52
4.49
e12/l
15.13
17272
85138
17680
87329
1.64
23.41
20.4
20.2
30.14
30.20
pg
5.16
17508
86334
17686
87367
1.64
23.39
20.6
20.4
135.53
134.92
g/l
6.89
17512
86378
17679
87327
1.63
23.31
20.4
20.2
90.42
90.52
fl
1.81
17506
86328
17684
87364
1.63
23.15
20.5
20.3
6.74
6.64
e9/l
5.40
17268
85176
16705
81664
1.34
23.01
10.3
10.4
26.01
25.93
u/l
0.21
16199
79250
16076
78175
1.29
23.01
13.7
14.0
21.71
22.43
mg/l
1.81
12775
60789
4250
18358
1.21
22.60
1.7
1.7
1.40
1.32
mmol/l
5.75
3621
15946
4943
21672
1.20
22.44
3.4
3.3
7.71
7.54
mmol/l
1.55
4245
18698
89
1257
0.35
22.27
2.4
2.5
—
—
—
0
0
15401
74562
1.25
22.21
4.7
4.5
2.77
2.78
mmol/l
0.22
14347
69912
552
4227
0.65
21.01
3.2
4.1
25.32
25.33
mmol/l
0.03
527
4118
1566
6146
1.31
18.84
3.7
4.0
—
—
—
0
0
165
363
2.29
18.68
14.2
12.5
807.17
3508.45
nmol/l
0.49
160
351
4040
17638
1.19
18.54
3.9
4.6
91.94
91.76
%
0.18
3927
17219
15172
73642
1.21
18.05
4.3
4.1
4.65
4.69
mmol/l
5.81
14241
69401
15050
73008
1.21
17.86
4.2
4.1
1.45
1.49
mmol/l
29.91
14058
68515
12028
57276
1.16
17.80
4.2
4.2
11.03
11.13
mm/h
0.34
11216
53652
4287
18882
1.18
17.65
2.2
2.3
2.79
2.87
mg/l
1.50
3697
16349
4270
18820
1.18
17.40
3.4
3.4
299.17
569.43
mg/l
3.57
2745
11880
4725
21076
1.17
16.48
3.9
5.0
7.40
7.40
ph
0.84
947
3836
167
391
2.16
16.44
19.7
16.5
1482.43
7175.80
nmol/l
0.72
162
372
16624
81619
1.27
16.28
12.7
13.1
—
—
—
0
0
14535
70422
1.18
16.23
3.8
3.7
1.29
1.24
mmol/l
10.66
13498
65823
4415
19632
1.17
15.90
3.1
3.2
—
—
—
0
0
750
5153
0.72
15.82
3.5
4.4
128.93
128.03
g/l
0.51
728
5041
9262
43480
1.14
15.64
4.7
5.2
6.58
6.53
mmol/l
1.37
8617
40111
7393
34218
1.14
15.25
9.5
9.8
0.00
0.00
e9/l
1.57
6035
28395
506
3694
0.68
15.15
6.0
5.3
1.66
1.60
%
0.80
474
3470
4286
19108
1.17
14.74
6.7
7.5
—
—
—
0
0
10773
51193
1.14
14.69
4.6
4.4
739.04
1632.27
e6/l
1.75
131
611
505
3658
0.68
14.50
6.0
5.3
0.91
0.90
%
0.26
475
3436
11285
53821
1.14
14.42
4.4
4.5
—
—
—
0
0
3462
15279
1.17
13.35
2.5
2.8
6.32
5.56
e6/l
2.15
3001
13458
5759
26409
1.14
13.02
6.1
6.8
—
—
—
0
0
4437
19995
1.15
12.91
4.2
4.1
8.10
11.44
mg/mmol
4.06
2802
12998
4466
20174
1.15
12.49
3.1
3.3
0.35
0.33
e6/l
0.39
3378
15373
5712
26245
1.14
12.37
3.7
3.9
89.85
81.57
e6/l
0.28
3977
18436
1564
6490
1.23
11.72
2.5
2.6
35.85
42.70
u/l
0.64
1318
5639
6561
30503
1.13
11.54
2.0
2.1
—
—
—
0
0
10523
50300
1.12
11.39
3.6
3.6
—
—
—
0
0
4822
22022
1.14
11.23
3.3
3.4
69.29
61.74
e6/l
0.18
3706
16979
156
418
1.88
10.89
12.4
10.3
0.62
0.62
mmol/l
0.01
143
375
3599
16151
1.15
10.82
1.5
1.5
20.21
20.89
nmol/l
1.69
3122
14077
478
1702
1.42
10.74
2.3
2.1
—
—
—
0
0
4328
19676
1.14
10.73
1.3
1.3
1.93
1.77
u/ml
0.26
1127
5258
1895
8086
1.20
10.67
4.4
4.1
31.97
32.69
%
2.02
1405
5747
2229
9651
1.18
10.64
1.2
1.2
—
—
—
0
0
320
1054
1.53
10.58
5.5
4.9
362.12
380.30
umol/l
1.38
283
904
13466
69743
0.88
10.51
17.7
17.4
332.73
333.07
g/l
4.13
13381
69232
496
1788
1.40
10.41
2.9
2.5
—
—
—
0
0
6199
28863
1.12
10.29
2.0
1.9
95.30
98.05
pmol/l
4.21
3306
15121
1884
8063
1.19
10.26
24.4
23.8
1.31
1.32
inr
0.14
263
1220
4655
21322
1.13
10.16
2.2
2.2
233.30
189.92
u/l
0.87
4391
20127
7744
36547
1.11
9.96
6.6
8.3
1.22
1.22
mmol/l
0.06
6533
31398
604
2269
1.35
9.89
1.4
1.3
—
—
—
0
0
584
3874
0.75
9.80
3.2
3.8
1.24
1.24
%
0.03
579
3853
2866
12781
1.15
9.28
1.3
1.3
9.16
10.24
u/ml
0.39
1089
5056
578
3784
0.76
8.84
3.2
3.8
0.64
0.68
%
3.09
554
3662
7827
37115
1.10
8.77
6.4
6.7
2.82
2.84
%
0.25
7269
34912
2063
9014
1.17
8.75
1.3
1.3
—
—
—
0
0
8037
38182
1.10
8.61
5.8
6.8
10.97
10.95
umol/l
0.04
7591
36203
2915
13080
1.14
8.58
3.6
3.7
315.31
410.84
ng/l
1.36
2095
9395
1553
6644
1.19
8.47
3.9
4.8
—
—
—
0
0
7869
37369
1.10
8.44
6.7
6.9
8.38
8.46
%
1.58
7358
35318
857
3463
1.26
8.20
2.0
1.8
—
—
—
0
0
7747
36832
1.10
7.93
3.0
3.0
102.30
114.89
ug/l
4.75
7213
34661
293
2082
0.70
7.72
3.7
3.4
21.85
24.54
mg/l
0.75
155
1357
7555
35917
1.10
7.65
6.5
6.7
0.67
0.67
%
0.03
7038
33771
10870
52552
1.10
7.64
3.2
3.1
44.47
44.31
u/l
0.06
10220
49729
8637
41319
1.10
7.63
6.5
6.7
0.19
0.19
e9/l
0.90
7636
37041
2219
9850
1.15
7.59
3.1
2.8
0.73
0.74
ug/l
0.10
1467
6299
1088
4569
1.21
7.27
2.3
2.3
7591.99
6246.39
u/l
0.53
414
1780
8321
39814
1.09
7.12
6.2
6.4
0.57
0.57
e9/l
0.54
7210
35245
2685
12124
1.13
7.08
2.8
2.9
2.44
2.44
mmol/l
0.05
2354
10703
2996
13625
1.13
7.03
1.3
1.3
32.23
30.82
iu/ml
0.16
915
4226
837
3437
1.23
6.99
2.2
1.9
—
—
—
0
0
387
1437
1.36
6.96
1.3
1.4
—
—
—
0
0
8349
39983
1.09
6.93
6.3
6.4
0.04
0.04
e9/l
1.97
7236
35351
78
726
0.54
6.77
31.8
39.1
7.78
7.43
ug/l
0.94
70
664
7978
38157
1.09
6.76
6.2
6.5
56.56
56.45
%
0.34
7448
36025
8088
38722
1.09
6.66
6.4
6.7
28.93
28.94
%
0.03
7518
36437
709
4367
0.81
6.58
3.0
3.6
—
—
—
0
0
3708
17141
1.11
6.44
1.5
1.5
2.31
2.25
g/l
0.98
2190
10829
727
2970
1.24
6.39
3.2
2.6
—
—
—
0
0
1233
5322
1.18
6.10
3.0
2.5
4.01
3.99
e9/l
0.08
1013
4194
1111
6505
0.85
5.98
3.7
5.0
4.81
4.70
kpa
0.89
1068
6345
1332
7686
0.86
5.95
4.4
5.8
1.89
1.80
mmol/l
0.41
1081
6374
977
4144
1.19
5.92
2.2
1.8
—
—
—
0
0
1871
8359
1.14
5.80
2.7
3.5
7.68
8.00
umol/l
0.25
1587
7301
9466
45776
1.08
5.74
9.2
9.6
4.05
3.98
e9/l
2.16
8270
40700
6715
32037
1.08
5.72
2.3
2.4
75.28
77.37
nmol/l
7.44
6119
29410
188
636
1.49
5.72
1.7
1.4
—
—
—
0
0
5396
25535
1.09
5.57
3.2
3.7
34.30
31.71
u/l
0.41
5121
24398
1343
7685
0.87
5.35
4.4
5.8
5.85
5.81
kpa
0.63
1294
7499
1049
4519
1.18
5.34
2.2
1.8
—
—
—
0
0
1029
4430
1.18
5.29
2.1
1.8
—
—
—
0
0
4211
19759
1.09
5.23
3.6
3.9
—
—
—
0
0
1601
7129
1.14
5.23
1.2
1.2
—
—
—
0
0
1044
4507
1.17
5.19
2.2
1.8
—
—
—
0
0
1038
4482
1.17
5.15
2.2
1.8
—
—
—
0
0
5120
24244
1.08
5.12
3.0
3.6
2.35
2.35
mmol/l
0.07
4524
21532
1393
7914
0.87
5.00
4.4
5.8
7.42
7.40
ph
—
9
31
87
252
1.74
5.00
2.2
2.0
186.32
81.87
ug/min
0.62
25
54
1778
8004
1.13
4.90
1.3
1.3
—
—
—
0
0
8547
41370
1.07
4.61
6.3
6.5
1.98
1.92
e9/l
0.99
7571
37148
5981
28594
1.08
4.56
8.4
8.9
1.22
1.21
inr
0.16
1840
8097
2750
12728
1.10
4.55
1.8
1.7
1162.34
1179.30
nmol/l
0.42
2128
10012
919
5322
0.86
4.36
1.3
1.4
—
—
—
0
0
311
1994
0.78
4.25
8.2
7.2
11.14
11.21
mmol/l
0.13
283
1800
701
4136
0.85
4.23
3.0
2.9
0.24
0.25
e6/l
0.18
677
4042
3574
16799
1.09
4.17
1.8
2.0
1.09
1.19
mg/l
0.98
2614
12779
312
1994
0.78
4.16
8.1
7.2
105.55
104.97
mmol/l
1.23
284
1800
846
4908
0.86
4.13
7.1
7.8
24.69
24.54
mmol/l
0.55
799
4557
68
567
0.60
4.11
4.8
5.0
—
—
—
0
0
149
519
1.45
4.05
1.4
1.3
1.47
1.46
nmol/l
0.04
136
472
15
210
0.36
4.05
1.8
2.8
—
—
—
0
0
18
28
3.23
4.03
4.8
3.2
—
—
—
0
0
4414
20946
1.08
4.03
3.9
4.1
0.00
0.00
estimate
0.17
1678
6666
1322
5920
1.13
4.00
7.2
8.1
1.35
1.31
mmol/l
0.50
1265
5722
1149
5109
1.14
3.89
3.1
3.2
4.53
4.53
pmol/l
0.07
1021
4616
82
254
1.62
3.80
1.6
2.3
—
—
—
0
0
733
3167
1.17
3.71
1.1
1.1
—
—
—
0
0
3843
18197
1.08
3.68
2.2
2.5
—
—
—
0
0
3946
18704
1.08
3.68
2.6
3.0
1480.93
6101.03
umol/l
17.31
3430
16614
78
241
1.63
3.66
2.9
2.3
157.36
147.95
nmol/l
0.36
70
208
2512
11701
1.09
3.61
3.0
3.0
2.87
3.11
e6/l
0.39
1345
6599
458
2757
0.83
3.53
5.1
7.4
1.38
1.43
mg/l
0.80
431
2618
357
2201
0.81
3.52
1.4
1.8
109.24
117.76
u/ml
0.72
69
489
383
2340
0.82
3.46
1.4
1.7
13.06
17.58
u/ml
—
6
50
429
1782
1.21
3.41
2.4
2.6
38.00
37.97
g/l
0.02
381
1525
4774
22840
1.07
3.38
3.0
3.0
—
—
—
0
0
457
2739
0.83
3.38
6.7
6.3
1.20
1.26
mmol/l
0.89
405
2449
386
2350
0.82
3.37
1.4
1.7
—
—
—
0
0
521
3084
0.84
3.34
1.9
2.2
2.15
2.20
ug/l
0.03
463
2743
278
1104
1.27
3.32
1.5
1.5
—
—
—
0
0
5502
26463
1.06
3.29
3.4
3.5
35.55
71.77
ng/l
1.08
3481
16669
80
608
0.66
3.28
24.1
30.4
119.21
124.45
ug/l
0.25
68
505
1993
9231
1.09
3.26
1.5
1.5
—
—
—
0
0
3861
18370
1.07
3.21
3.0
3.3
1156.87
1325.66
ng/l
1.26
3240
15761
879
4989
0.88
3.20
5.1
5.5
—
—
—
0
0
1599
8776
0.91
3.19
1.3
1.3
—
—
—
0
0
13513
66754
1.07
3.19
16.7
16.4
13.55
13.55
%
0.01
13251
65471
162
603
1.35
3.11
2.5
2.9
—
—
—
0
0
127
454
1.41
3.10
1.2
1.1
6.51
5.98
nmol/l
0.05
21
82
23
49
2.36
3.08
9.4
5.6
—
—
—
0
0
3199
15152
1.07
3.01
1.7
1.6
11821988.11
43564109.08
pmol/l
4.01
2690
12880
5013
24101
1.06
2.99
2.6
2.7
56.34
58.22
u/l
1.49
4635
22389
1046
4712
1.12
2.95
7.5
9.9
24.89
24.73
mmol/l
0.70
1040
4671
263
1639
0.80
2.94
1.2
1.2
—
—
—
0
0
1604
7394
1.10
2.92
1.4
1.4
—
—
—
0
0
212
1353
0.78
2.92
1.2
1.2
—
—
—
0
0
120
430
1.40
2.92
1.8
2.0
—
—
—
0
0
226
1430
0.79
2.90
2.4
2.5
—
—
—
0
0
860
3833
1.13
2.89
1.6
1.6
303.43
309.68
mu/l
0.24
774
3480
440
1865
1.19
2.88
3.7
4.4
7.42
7.42
ph
0.10
378
1573
3990
19069
1.07
2.87
4.3
4.5
—
—
—
0
0
148
551
1.35
2.87
1.9
1.7
6.52
6.23
mmol/l
0.54
109
418
3103
14706
1.07
2.87
2.7
2.9
549.41
551.07
mosm/kgh2o
0.14
2627
12625
446
1895
1.19
2.85
1.9
1.8
4.14
21.14
iu/l
0.73
175
643
828
3686
1.13
2.84
1.1
1.1
2.35
15.06
u/ml
1.06
11
64
106
742
0.72
2.83
1.8
1.9
2.35
2.34
u/field
0.01
65
253
70
527
0.67
2.80
1.6
2.1
—
—
—
0
0
71
532
0.67
2.77
1.1
1.2
—
—
—
0
0
383
1611
1.20
2.75
3.9
4.5
2.43
2.46
mmol/l
0.07
260
1048
383
1612
1.20
2.73
3.9
4.5
5.01
5.00
kpa
0.04
378
1572
29
73
2.00
2.68
8.6
9.9
—
—
—
0
0
58
182
1.60
2.66
1.1
1.2
—
—
—
0
0
384
1621
1.19
2.66
3.9
4.5
8.71
8.80
kpa
0.44
378
1581
732
3249
1.14
2.66
10.0
10.8
24.33
24.24
mmol/l
0.31
701
3048
1266
5799
1.10
2.65
3.7
4.4
1.23
1.23
mmol/l
0.54
1097
5155
114
413
1.39
2.64
1.5
1.4
5.69
5.38
mmol/l
0.80
108
384
52
410
0.64
2.62
2.6
2.9
307.42
208.02
e6/l
0.65
31
237
2390
11262
1.08
2.60
1.4
1.4
469.19
546.43
titre
1.38
496
2214
68
506
0.67
2.59
1.1
1.1
—
—
—
0
0
290
1198
1.22
2.54
1.1
1.1
106.49
2314.60
iu/ml
1.05
81
264
3491
18420
0.94
2.53
3.9
4.0
1.02
1.02
kg/l
1.72
506
2752
2368
11169
1.07
2.51
2.4
2.5
117.13
127.59
ug/g
0.80
1847
8857
69
508
0.68
2.50
1.0
1.0
—
—
—
0
0
6519
31703
1.05
2.48
4.8
5.7
36.05
35.92
g/l
0.98
6075
29649
3811
18266
1.06
2.48
4.9
4.8
2.78
2.98
ug/l
0.23
3406
16632
362
1534
1.19
2.44
3.7
3.4
3.98
4.03
e9/l
0.14
362
1529
1645
7659
1.09
2.44
2.1
2.3
364.15
377.73
nmol/l
1.84
1518
7120
303
1264
1.21
2.42
1.6
1.5
—
—
—
0
0
119
794
0.75
2.38
2.7
3.0
507.75
532.77
e6/l
0.23
100
660
2690
12769
1.07
2.38
2.8
2.8
1.09
1.04
e6/l
0.25
1518
7635
842
3799
1.12
2.37
5.0
7.4
24.16
23.93
mmol/l
1.17
777
3496
54
172
1.58
2.37
1.4
1.4
—
—
—
0
0
386
1653
1.18
2.32
1.1
1.1
—
—
—
0
0
223
908
1.24
2.28
1.3
1.3
—
—
—
0
0
297
1773
0.84
2.23
1.4
1.3
3.39
3.71
ug/l
0.63
269
1624
580
3291
0.88
2.21
1.5
1.4
—
—
—
0
0
190
1183
0.80
2.20
3.6
4.0
29.76
38.17
u/ml
0.71
184
1137
117
772
0.76
2.19
2.8
3.0
0.18
0.23
e9/l
2.16
101
657
1715
8037
1.08
2.18
2.7
3.2
1.71
1.75
%
1.07
1520
7216
94
638
0.74
2.15
1.4
1.3
68.97
117.70
pmol/l
0.46
31
187
507
2237
1.14
2.09
2.5
2.5
—
—
—
0
0
1158
5357
1.09
2.03
1.3
1.2
—
—
—
0
0
84
574
0.73
2.03
1.9
1.5
—
—
—
0
0
10
119
0.42
2.01
1.0
1.1
—
—
—
0
0
22
198
0.56
1.96
1.4
1.3
—
—
—
0
0
69
483
0.72
1.96
2.5
3.6
—
—
—
0
0
252
1058
1.20
1.95
3.2
3.3
0.75
0.83
nmol/l
1.94
198
808
330
1419
1.17
1.95
2.6
2.5
98.72
141.87
ug/min
0.91
199
835
178
723
1.24
1.92
4.4
4.1
65.28
130.67
u/ml
1.33
53
203
220
916
1.21
1.88
1.2
1.2
—
—
—
0
0
1303
6082
1.08
1.87
4.1
4.1
0.62
0.67
%
0.27
279
1369
2520
12034
1.06
1.86
2.4
2.9
13.37
13.49
umol/l
0.34
2321
11214
12
128
0.47
1.84
1.1
1.2
—
—
—
0
0
653
2954
1.11
1.83
1.6
1.7
—
—
—
0
0
416
2377
0.88
1.82
3.6
3.3
2187.85
4018.86
u/ml
0.25
344
2024
1313
6138
1.08
1.82
1.2
1.2
155.71
134.46
iu/ml
0.73
484
2381
195
805
1.22
1.82
1.5
1.7
282.42
281.32
mosm/kgh2o
0.24
149
648
503
2242
1.13
1.82
2.5
2.8
3.15
3.06
g/l
1.07
399
1704
25
212
0.59
1.81
1.3
1.7
—
—
—
0
0
89
333
1.34
1.80
2.4
2.5
54.25
55.78
umol/l
0.17
71
276
195
1182
0.83
1.80
1.4
1.8
—
—
—
0
0
195
1182
0.83
1.80
1.4
1.8
—
—
—
0
0
195
1182
0.83
1.80
1.4
1.8
—
—
—
0
0
195
1182
0.83
1.80
1.4
1.8
—
—
—
0
0
5285
27363
0.96
1.78
2.6
2.6
—
—
—
0
0
4082
19771
1.05
1.77
2.0
2.0
—
—
—
0
0
100
651
0.77
1.76
1.2
1.2
—
—
—
0
0
80
296
1.36
1.75
2.5
2.4
9.89
9.25
mmol/l
0.50
65
202
1709
9109
0.94
1.74
7.0
7.6
104.20
104.50
mmol/l
1.78
1670
8949
6
8
3.77
1.73
2.0
2.0
—
—
—
0
0
6
8
3.77
1.73
1.0
1.0
—
—
—
0
0
124
490
1.27
1.72
1.7
1.6
6.60
5.65
u/l
0.49
112
423
100
385
1.31
1.69
1.7
1.7
1.89
2.46
u/field
0.45
76
282
154
627
1.24
1.67
1.7
1.4
1.28
1.29
promille
0.01
117
479
240
1021
1.18
1.66
1.3
1.3
0.33
0.14
nmol/l
0.88
13
58
129
515
1.26
1.66
2.3
2.5
—
—
—
0
0
1265
5931
1.08
1.65
4.5
4.4
0.12
0.11
%
0.05
297
1480
93
356
1.31
1.65
3.7
2.3
135.14
149.32
umol/l
0.19
56
177
3000
14453
1.05
1.62
4.3
4.3
21.80
22.06
%
0.38
1360
6774
2293
10972
1.06
1.60
2.5
2.9
2.38
2.35
g/l
1.15
2104
10231
537
2994
0.90
1.60
4.5
5.4
—
—
—
0
0
104
664
0.79
1.60
1.3
1.1
364.35
381.41
nmol/l
0.40
91
569
106
675
0.79
1.60
1.4
1.4
33.80
32.85
nmol/l
0.12
91
635
52
366
0.71
1.58
2.2
2.6
62.47
70.75
ug/l
0.36
52
356
26
77
1.70
1.58
1.0
1.1
—
—
—
0
0
499
2789
0.90
1.57
2.9
3.7
3.48
3.45
g/l
0.22
478
2673
172
1038
0.83
1.56
2.6
2.8
1.25
1.16
e9/l
0.60
107
653
96
373
1.29
1.55
1.4
1.3
136.24
138.09
nmol/l
0.15
96
373
463
2078
1.12
1.55
8.8
9.7
—
—
—
0
0
275
1193
1.16
1.53
1.0
1.0
0.35
0.50
u/ml
0.28
70
254
14601
73975
0.96
1.52
14.8
14.7
40.34
39.06
%
73.63
10874
55882
475
2657
0.90
1.52
1.5
1.5
—
—
—
0
0
11
24
2.30
1.48
1.0
1.0
—
—
—
0
0
282
1625
0.87
1.47
1.4
1.5
0.33
0.40
nmol/l
1.27
221
1324
233
1002
1.17
1.46
1.2
1.3
41.79
40.77
u/l
0.03
201
886
59
400
0.74
1.45
4.5
8.2
68.77
1881.00
mg/l
1.35
43
317
297
1302
1.15
1.45
1.6
1.4
—
—
—
0
0
478
2663
0.90
1.44
1.5
1.5
—
—
—
0
0
240
1036
1.17
1.44
1.3
1.3
0.64
2.01
nmol/l
0.69
229
1003
88
342
1.29
1.44
2.1
2.3
21.96
559.22
ug/l
1.08
79
318
1246
6661
0.94
1.43
3.7
4.0
23.79
18.07
ug/l
0.31
993
5254
471
2130
1.11
1.41
1.3
1.3
1022.35
1150.96
titre
0.14
17
52
258
1489
0.87
1.39
1.2
1.2
—
—
—
0
0
21
172
0.61
1.39
4.7
3.0
25.95
26.42
mg/l
—
6
22
2359
11348
1.05
1.37
1.6
1.8
—
—
—
0
0
490
2718
0.90
1.37
1.5
1.5
—
—
—
0
0
124
760
0.82
1.36
2.6
2.9
693.02
687.95
e6/l
0.03
50
272
31
101
1.54
1.35
1.8
1.7
—
—
—
0
0
116
471
1.24
1.35
1.5
1.4
66.89
68.80
umol/l
—
9
46
138
835
0.83
1.34
1.5
1.4
31.29
32.42
g/l
0.49
126
769
450
2038
1.11
1.33
1.5
1.6
500.06
519.22
mg/l
0.23
423
1961
770
4176
0.92
1.32
1.4
1.4
—
—
—
0
0
8
16
2.51
1.32
1.3
1.3
—
—
—
0
0
35
118
1.49
1.32
1.7
2.3
6.78
7.04
mmol/l
0.23
20
73
53
358
0.74
1.30
1.2
1.3
—
—
—
0
0
5
8
3.14
1.30
3.6
1.5
1.92
1.84
ug/l
—
5
8
3349
16266
1.04
1.29
1.7
1.8
—
—
—
0
0
115
704
0.82
1.27
1.2
1.2
—
—
—
0
0
1940
9308
1.05
1.27
1.8
1.8
—
—
—
0
0
1505
7171
1.06
1.27
1.4
1.5
—
—
—
0
0
197
849
1.17
1.25
1.5
1.8
—
—
—
0
0
69
266
1.30
1.23
1.9
2.3
—
—
—
0
0
1224
5801
1.06
1.23
1.3
1.3
217.02
210.64
u/ml
0.08
1132
5394
408
2269
0.90
1.23
3.9
4.9
3.85
3.89
mmol/l
1.11
377
2160
1057
4988
1.07
1.22
1.3
1.3
49.84
45.79
au/ml
0.16
35
196
104
423
1.24
1.22
6.6
6.1
—
—
—
0
0
81
320
1.27
1.21
1.0
1.1
4.36
10.95
u/ml
—
8
37
0
20
0.00
1.20
0.0
1.0
—
0.17
—
0
9
399
2217
0.90
1.19
4.0
6.2
8.87
8.90
kpa
0.10
376
2083
279
1238
1.13
1.19
1.2
1.2
—
—
—
0
0
268
1521
0.88
1.17
1.1
1.1
—
—
—
0
0
5
9
2.79
1.17
2.0
3.1
—
—
—
0
0
190
1103
0.86
1.16
1.3
1.3
54.12
51.44
u/ml
0.04
13
71
268
1520
0.88
1.16
1.1
1.1
—
—
—
0
0
45
305
0.74
1.16
1.4
1.8
—
—
—
0
0
59
225
1.32
1.15
1.1
1.3
15.33
28.55
%
—
6
47
84
336
1.26
1.15
1.6
1.5
6.62
5.74
mmol/24h
—
9
25
268
1519
0.88
1.15
1.2
1.2
—
—
—
0
0
222
973
1.15
1.15
1.6
1.7
63.13
61.83
mu/l
0.03
193
894
473
2168
1.10
1.14
1.3
1.3
75.45
99.95
titre
1.04
33
212
14
120
0.59
1.14
6.4
3.4
2.00
7.09
%
—
6
43
2114
10194
1.05
1.14
2.6
3.1
22.81
23.20
%
0.59
1791
8581
7950
39270
1.03
1.14
3.6
3.7
0.00
0.00
estimate
0.19
1665
6754
1293
6847
0.94
1.14
8.5
8.7
122.06
120.13
g/l
2.62
1253
6573
256
1134
1.14
1.14
1.4
1.3
6.94
6.82
mmol/l
0.21
177
816
467
2140
1.10
1.14
1.4
1.4
300.72
282.40
ug/g
0.91
242
1223
24
181
0.67
1.14
1.4
1.4
—
—
—
0
0
12
31
1.94
1.13
1.5
1.4
10.03
20.43
nmol/l
0.95
12
31
95
387
1.23
1.12
1.0
1.0
701.98
717.20
ng/l
0.11
60
260
18
54
1.67
1.10
1.2
1.2
—
—
—
0
0
31
221
0.70
1.10
8.0
9.3
—
—
—
0
0
416
1900
1.10
1.09
1.4
1.4
—
—
—
0
0
131
553
1.19
1.09
1.4
1.8
—
—
—
0
0
127
536
1.19
1.07
1.2
1.2
—
—
—
0
0
142
836
0.85
1.06
2.2
2.5
10.49
13.83
%
2.29
63
483
8031
39706
1.03
1.06
3.6
3.8
0.00
0.00
estimate
0.24
1673
6793
98
596
0.82
1.06
1.4
1.3
6.07
6.14
mmol/l
0.10
90
562
467
2149
1.09
1.06
3.2
3.2
—
—
—
0
0
137
583
1.18
1.05
1.1
1.1
10.45
7.91
iu/ml
0.45
30
152
7
16
2.20
1.05
1.1
1.0
—
—
—
0
0
86
529
0.82
1.05
1.3
1.8
1978.91
2031.77
ml
0.06
11
154
74
296
1.26
1.04
1.1
1.1
—
—
—
0
0
0
16
0.00
1.04
0.0
1.1
—
—
—
0
0
71
445
0.80
1.03
1.3
1.3
11.38
13.24
u/l
0.59
66
408
410
2254
0.91
1.03
1.2
1.5
234.20
251.71
u/ml
0.67
253
1439
391
1790
1.10
1.00
1.5
1.7
25.76
41.19
e6/l
0.57
302
1430
80
325
1.24
1.00
2.9
3.3
212.34
122.41
au/ml
0.52
12
42
205
1168
0.88
1.00
7.0
7.0
12.10
11.26
mg/l
1.69
189
1083
1321
6323
1.05
0.99
4.5
4.4
0.11
0.14
%
0.75
346
1778
89
366
1.22
0.99
1.5
1.6
1.29
1.23
nmol/l
0.21
72
281
17
52
1.64
0.99
1.2
2.2
35.71
53.31
umol/l
2.03
17
52
99
596
0.83
0.98
2.7
2.9
46.92
36.61
%
4.36
31
237
78
317
1.24
0.97
1.1
1.1
—
—
—
0
0
60
380
0.79
0.97
1.3
1.3
—
—
—
0
0
13
108
0.60
0.97
3.8
5.0
—
—
—
0
0
391
1795
1.10
0.96
1.5
1.8
11317.95
1452.62
e6/l
0.54
320
1503
2517
12237
1.04
0.95
3.5
4.6
0.82
0.82
mmol/l
0.21
2369
11545
6
13
2.32
0.95
3.5
1.7
—
—
—
0
0
54
345
0.79
0.95
1.4
1.2
—
—
—
0
0
209
928
1.13
0.94
1.3
1.3
—
—
nmol/l
—
0
0
3682
18971
0.97
0.94
4.7
4.6
—
—
—
0
0
93
388
1.21
0.92
1.0
1.0
302.16
331.31
ng/l
0.45
58
278
12
100
0.60
0.92
1.1
1.4
—
242.75
—
0
8
12
100
0.60
0.92
1.1
1.2
—
—
—
0
0
643
3450
0.93
0.91
1.6
1.6
22.75
15.34
u/ml
0.34
20
104
129
753
0.86
0.91
1.4
1.5
1900.40
2761.92
e6/l
0.93
92
567
148
644
1.16
0.90
1.5
1.3
1.93
2.04
mmol/l
0.84
142
599
386
1778
1.09
0.90
1.5
1.4
156.27
112.05
pmol/l
0.58
377
1726
6
14
2.15
0.90
1.0
1.0
—
—
—
0
0
397
2168
0.92
0.89
1.4
1.6
10.81
14.99
iu/ml
0.48
11
54
100
594
0.84
0.88
1.0
1.0
—
—
—
0
0
126
543
1.17
0.88
1.1
1.1
1.03
1.07
ratio
1.90
50
183
49
191
1.29
0.88
2.1
1.9
16.59
17.25
umol/l
0.14
49
191
393
1816
1.09
0.86
1.4
1.6
3.66
3.68
mmol/l
0.15
371
1723
22
158
0.70
0.86
9.5
8.2
—
—
—
0
0
1134
5433
1.05
0.85
2.4
2.4
20.31
21.72
au/ml
0.16
57
324
768
4086
0.94
0.85
10.5
10.3
—
—
—
0
0
649
3059
1.07
0.85
1.1
1.1
—
—
—
0
0
22
75
1.47
0.85
1.1
1.0
—
—
—
0
0
17
128
0.67
0.85
1.0
1.1
0.05
0.48
u/ml
0.82
12
73
0
13
0.00
0.84
0.0
1.0
—
—
—
0
0
103
607
0.85
0.84
1.6
1.5
—
—
—
0
0
24
84
1.44
0.82
1.0
1.0
—
—
—
0
0
5
50
0.50
0.82
1.0
1.3
—
1.33
—
0
19
42
162
1.30
0.82
1.6
1.5
—
—
—
0
0
156
890
0.88
0.82
2.3
2.5
43.31
39.60
%
0.40
16
106
57
354
0.81
0.81
8.3
12.1
—
—
—
0
0
267
1216
1.10
0.81
1.1
1.1
116.00
115.80
%
0.03
240
1119
52
326
0.80
0.81
1.1
1.2
—
—
—
0
0
945
4515
1.05
0.81
1.2
1.2
94.23
207.28
titre
1.27
26
127
204
916
1.12
0.80
1.5
1.4
302.49
313.63
pmol/l
0.19
159
745
19
138
0.69
0.80
1.0
1.1
0.07
3.87
u/ml
—
10
75
59
239
1.24
0.80
2.5
2.3
—
—
—
0
0
384
1781
1.08
0.79
1.6
1.7
11829.28
12692.24
e6/l
0.15
265
1342
84
354
1.19
0.78
1.4
1.5
5.44
6.23
%
0.09
16
73
16
52
1.55
0.77
1.5
1.1
—
—
—
0
0
284
1302
1.10
0.77
1.6
1.6
—
—
—
0
0
6
56
0.54
0.76
1.0
1.1
—
—
—
0
0
951
4553
1.05
0.76
2.3
2.7
—
—
—
0
0
1257
6059
1.05
0.76
2.6
2.9
69.14
69.28
e9/l
0.05
956
4700
1404
7328
0.96
0.76
8.2
8.4
96.06
96.06
%
0.00
1362
7007
325
1501
1.09
0.75
2.2
2.6
16.62
16.42
%
0.32
143
779
274
1506
0.91
0.75
1.6
1.9
—
—
—
0
0
94
402
1.18
0.75
1.4
1.4
75.35
51.61
%
2.04
17
54
453
2121
1.07
0.75
1.2
1.2
—
—
—
0
0
1035
4969
1.05
0.75
1.9
1.9
1.39
1.26
g/l
0.95
952
4562
773
3683
1.06
0.75
3.8
5.6
—
—
—
0
0
101
435
1.17
0.74
1.1
1.2
36.36
16.42
u/ml
0.29
11
48
231
1051
1.11
0.74
3.1
3.4
58.45
338.03
u/ml
0.83
212
996
35
227
0.77
0.74
1.5
1.4
57.27
62.27
%
0.34
30
193
135
595
1.14
0.73
1.0
1.1
294.99
284.22
mg/l
0.71
120
530
39
152
1.29
0.73
1.0
1.2
—
—
—
0
0
182
818
1.12
0.73
1.8
2.2
—
—
—
0
0
522
2460
1.07
0.73
2.4
2.7
7.38
7.34
g/l
0.19
409
1726
83
353
1.18
0.72
2.5
2.3
2030.69
1904.91
ml
0.33
75
324
1297
6267
1.04
0.71
8.6
10.3
—
—
—
0
0
10
81
0.62
0.71
2.2
3.1
—
—
—
0
0
1392
6737
1.04
0.71
4.4
4.3
0.89
0.99
%
0.64
376
1921
34
220
0.78
0.71
1.7
2.2
—
—
—
0
0
212
963
1.11
0.71
1.3
1.3
—
—
—
0
0
520
2453
1.07
0.71
2.4
2.7
3.83
3.77
g/l
0.33
394
1640
20
140
0.72
0.71
1.0
1.1
0.09
1.60
u/ml
1.13
15
72
287
1568
0.92
0.70
1.4
1.4
22.36
24.01
u/l
0.42
246
1300
26
96
1.36
0.70
2.5
2.9
—
—
—
0
0
39
247
0.79
0.69
1.1
1.1
15.85
9.83
u/ml
0.21
31
173
74
439
0.85
0.69
1.4
1.8
—
—
—
0
0
121
691
0.88
0.68
1.1
1.2
—
—
—
0
0
14
104
0.68
0.68
3.1
2.2
—
—
—
0
0
324
1505
1.08
0.68
3.9
5.5
—
—
—
0
0
301
1394
1.09
0.68
1.1
1.1
—
—
—
0
0
297
1375
1.09
0.68
1.1
1.1
—
—
—
0
0
8
66
0.61
0.67
4.1
3.1
—
—
—
0
0
337
1569
1.08
0.67
2.4
2.5
7.17
7.04
umol/l
0.02
244
1199
353
1647
1.08
0.67
2.1
2.3
131.36
129.74
g/l
0.55
256
1247
129
732
0.88
0.67
1.2
1.2
305.56
181.57
titre
0.68
27
127
729
3848
0.95
0.66
1.3
1.4
—
—
—
0
0
285
1552
0.92
0.66
1.9
2.0
3.33
5.54
titre
—
6
28
12
38
1.59
0.65
1.6
1.3
378.42
280.74
umol/24h
0.82
12
38
58
349
0.83
0.65
1.5
1.5
—
—
—
0
0
254
1388
0.92
0.65
3.4
3.6
1.51
1.55
%
0.06
206
1056
135
762
0.89
0.65
3.0
2.8
31.94
45.45
mg/l
0.50
105
526
1332
6930
0.96
0.64
7.7
11.1
8.64
9.32
mmol/l
3.23
1281
6660
5
14
1.79
0.64
1.0
1.1
68.78
61.56
%
—
5
14
200
913
1.10
0.63
3.1
2.7
—
—
—
0
0
185
1024
0.91
0.63
2.0
2.2
23.31
29.60
mg/l
0.83
60
288
0
12
0.00
0.63
0.0
1.1
—
—
—
0
0
23
85
1.36
0.62
2.3
2.1
0.83
0.55
u/field
0.64
23
85
232
1270
0.92
0.62
2.8
3.4
—
—
—
0
0
869
4557
0.96
0.62
1.7
1.6
—
—
—
0
0
8
25
1.61
0.62
1.5
1.0
—
—
—
0
0
170
771
1.11
0.61
1.6
1.6
—
—
—
0
0
32
125
1.29
0.61
1.5
1.6
—
—
—
0
0
20
136
0.74
0.61
1.2
1.2
2.32
1.63
mmol/l
0.64
12
87
189
1043
0.91
0.61
1.6
1.6
—
—
—
0
0
86
374
1.16
0.60
4.2
2.6
—
—
—
0
0
100
571
0.88
0.59
1.4
1.5
—
—
—
0
0
26
169
0.77
0.59
1.3
1.2
0.90
48.70
mg/l
1.05
21
117
520
2474
1.06
0.58
1.1
1.2
—
—
—
0
0
6
18
1.67
0.57
2.5
1.8
261.50
247.23
nmol/l
—
6
13
37
229
0.81
0.57
1.1
1.2
40.56
38.98
g/l
0.30
21
122
460
2444
0.94
0.56
1.8
1.7
40.29
42.16
nmol/l
0.83
445
2394
23
87
1.33
0.56
7.7
3.8
41.56
43.18
umol/l
0.13
18
73
272
1470
0.93
0.56
1.7
1.6
0.70
0.72
g/l
0.12
199
1122
76
330
1.16
0.55
2.7
3.5
1.24
1.47
ug/l
0.53
70
315
2400
11783
1.03
0.55
1.8
1.7
—
—
—
0
0
13
93
0.70
0.55
1.2
1.3
5.10
5.35
mmol/l
—
5
40
120
673
0.89
0.55
1.4
1.5
88071.64
68384.21
e6/l
0.13
67
416
178
816
1.10
0.54
2.2
2.0
32.28
32.72
pg
0.67
178
806
9
69
0.66
0.54
1.0
1.2
—
—
—
0
0
6
19
1.59
0.54
2.2
1.0
—
—
—
0
0
137
620
1.11
0.54
1.2
1.2
72.20
39.49
u/ml
—
6
30
312
1675
0.93
0.54
3.4
4.2
—
—
—
0
0
277
1295
1.08
0.54
3.6
3.3
1124.59
462.59
u/ml
0.33
254
1171
50
210
1.20
0.54
1.4
1.3
126.30
110.26
nmol/l
0.25
36
159
360
1699
1.07
0.54
1.5
1.7
—
—
—
0
0
32
128
1.26
0.53
1.1
1.1
—
—
—
0
0
1241
6435
0.97
0.53
3.5
3.7
—
—
—
0
0
344
1622
1.07
0.53
3.5
4.1
—
—
—
0
0
39
160
1.22
0.53
2.0
4.4
139.00
46.09
u/l
0.42
12
55
23
88
1.31
0.52
1.2
1.6
—
—
—
0
0
83
365
1.14
0.52
3.6
3.8
7.36
8.61
mg/l
1.15
65
291
55
234
1.18
0.52
1.3
2.0
—
—
—
0
0
29
115
1.27
0.52
1.1
1.1
—
—
—
0
0
4919
24370
1.02
0.51
2.3
2.5
—
—
—
0
0
144
796
0.91
0.51
1.7
2.5
—
—
—
0
0
7
56
0.63
0.51
1.0
1.3
—
0.18
—
0
19
16
58
1.39
0.50
1.6
2.0
—
—
—
0
0
1217
5927
1.03
0.50
2.3
2.4
7.02
7.24
ug/l
0.13
1088
5194
7935
39489
1.02
0.49
4.7
5.2
0.00
0.00
estimate
0.08
1716
6948
19
125
0.76
0.49
2.7
4.2
—
—
—
0
0
152
835
0.91
0.48
2.6
3.8
55.83
56.76
%
0.17
103
520
52
222
1.18
0.48
1.3
1.4
39.61
38.98
%
0.04
36
147
71
311
1.15
0.48
3.5
2.9
—
—
—
0
0
496
2614
0.95
0.48
1.7
1.8
0.23
0.23
g/l
0.22
472
2477
16
107
0.75
0.47
1.0
1.8
—
83.81
—
0
11
190
882
1.08
0.47
1.6
1.5
20.25
37.32
iu/ml
1.72
12
40
13
46
1.42
0.46
1.2
1.0
—
—
—
0
0
91
407
1.12
0.46
1.0
1.1
8.02
11.17
u/ml
0.31
15
71
234
1096
1.07
0.46
1.1
1.1
1.49
1.49
g/l
0.02
205
1000
109
493
1.11
0.46
1.6
1.4
10.29
7.02
ug/l
0.93
90
442
1565
8058
0.97
0.45
7.7
8.0
1.14
1.12
mmol/l
0.06
1240
6284
144
662
1.09
0.45
1.1
1.2
—
—
—
0
0
19
73
1.31
0.44
1.1
1.2
—
—
—
0
0
0
8
0.00
0.43
0.0
4.1
—
349.38
—
0
8
0
8
0.00
0.43
0.0
1.8
—
—
—
0
0
1091
5643
0.97
0.43
2.8
3.1
—
—
—
0
0
37
155
1.20
0.43
1.2
1.2
227.00
430.13
pmol/l
1.30
29
119
67
382
0.88
0.43
1.1
1.1
—
—
—
0
0
0
9
0.00
0.43
0.0
17.8
—
4.18
—
0
9
78
440
0.89
0.43
2.3
2.1
14.84
36.75
umol/l
—
7
49
5
16
1.57
0.42
1.0
1.0
—
—
—
0
0
5
16
1.57
0.42
1.2
1.4
—
—
—
0
0
695
3365
1.04
0.42
4.0
5.7
24.64
24.63
mmol/l
0.01
654
3197
330
1749
0.95
0.42
1.3
1.2
1.98
7.18
u/ml
1.31
26
119
37
220
0.84
0.41
1.1
1.2
—
193.33
—
0
6
0
10
0.00
0.41
0.0
6.5
—
—
—
0
0
0
10
0.00
0.41
0.0
3.7
—
140.10
—
0
10
1230
6344
0.97
0.41
1.4
1.5
—
—
—
0
0
17
65
1.31
0.41
1.0
1.1
0.34
0.34
u/ml
—
8
25
31
187
0.83
0.41
2.1
2.1
6567.19
14039.39
e6/l
0.62
16
110
35
147
1.20
0.41
2.3
2.4
—
—
—
0
0
4350
21579
1.02
0.40
3.1
3.3
—
—
—
0
0
515
2696
0.96
0.40
1.7
1.8
1.18
1.16
g/l
1.00
493
2563
77
345
1.12
0.40
2.0
2.1
—
—
—
0
0
16
103
0.78
0.37
1.9
2.3
1.73
3.60
nmol/l
1.15
16
93
80
446
0.90
0.37
1.1
1.1
1451.89
1581.17
miu/ml
0.47
80
446
240
1278
0.94
0.37
1.5
1.9
—
—
—
0
0
36
212
0.85
0.37
2.2
2.2
442.65
1040.54
e6/l
1.35
26
158
392
1882
1.05
0.37
1.1
1.1
1.56
1.16
u/ml
0.35
177
877
34
201
0.85
0.37
1.0
1.1
—
—
—
0
0
12
44
1.37
0.37
1.0
1.1
1.70
0.32
u/ml
—
6
28
181
972
0.93
0.37
1.4
1.4
6.34
6.86
g/l
1.59
122
696
12
80
0.75
0.36
9.3
11.9
136.00
150.78
e6/l
—
7
64
181
971
0.94
0.36
1.4
1.4
2.90
2.90
g/l
0.01
121
703
181
971
0.94
0.36
1.4
1.4
0.35
0.41
g/l
1.56
120
704
199
939
1.07
0.35
1.6
1.6
7.86
7.34
mmol/l
1.75
125
559
256
1357
0.95
0.35
1.1
1.1
2.53
2.18
u/ml
0.33
113
677
31
131
1.19
0.35
1.0
1.1
3.83
2.65
u/ml
0.16
24
103
13
49
1.33
0.35
1.0
1.1
2.22
0.25
u/ml
—
6
23
1025
5018
1.03
0.35
3.8
5.2
5.16
5.10
kpa
1.71
954
4688
15
96
0.78
0.34
1.0
1.1
34.80
34.43
u/ml
—
5
18
26
156
0.84
0.34
1.4
1.3
14.84
13.73
g/l
0.28
19
118
1439
7078
1.02
0.34
2.3
2.6
0.22
0.22
g/l
0.99
1346
6669
167
785
1.07
0.34
1.4
1.4
12.82
10.92
mmol/l
1.30
38
134
67
374
0.90
0.33
1.1
1.0
—
—
—
0
0
482
2332
1.04
0.33
2.4
2.8
10.19
10.02
g/l
0.40
414
1903
14
54
1.30
0.33
1.1
1.1
—
—
—
0
0
7
50
0.70
0.32
1.0
1.0
—
—
—
0
0
7
50
0.70
0.32
1.0
1.0
—
—
—
0
0
7
50
0.70
0.32
1.0
1.0
—
—
—
0
0
34
198
0.86
0.32
1.9
2.6
—
—
—
0
0
7
51
0.69
0.32
1.0
1.0
—
—
—
0
0
7
51
0.69
0.32
1.0
1.0
—
—
—
0
0
7
51
0.69
0.32
4.3
13.1
—
—
—
0
0
339
1777
0.96
0.31
1.3
1.2
50.36
46.83
u/ml
0.14
42
177
37
161
1.15
0.31
3.0
2.4
2.07
1.62
mmol/l
0.30
29
108
49
277
0.89
0.31
1.1
1.0
—
—
—
0
0
60
335
0.90
0.31
1.2
1.2
—
—
—
0
0
28
119
1.18
0.31
1.4
1.2
22.67
108.64
titre
—
6
11
77
352
1.10
0.31
2.0
2.1
8.48
8.86
%
0.10
77
342
409
2133
0.96
0.30
3.5
4.2
59.40
75.78
mg/l
0.28
332
1760
26
110
1.19
0.30
1.1
1.2
—
—
—
0
0
1569
8025
0.98
0.30
7.8
8.0
5.13
5.04
kpa
2.87
1512
7641
1569
8024
0.98
0.30
7.8
8.0
12.73
12.82
kpa
0.24
1516
7640
18
110
0.82
0.29
1.1
1.1
—
—
—
0
0
12
77
0.78
0.29
1.0
1.1
—
—
—
0
0
65
296
1.10
0.29
1.6
1.6
15.63
15.19
pmol/l
0.10
57
245
56
312
0.90
0.29
1.3
1.3
—
—
—
0
0
54
301
0.90
0.28
1.1
1.4
—
—
—
0
0
182
965
0.95
0.28
1.4
1.4
—
—
—
0
0
31
179
0.87
0.27
1.7
2.0
—
—
—
0
0
1010
4965
1.02
0.27
3.8
5.2
7.42
7.42
ph
0.12
113
538
18
74
1.22
0.27
1.4
1.1
—
—
—
0
0
410
2131
0.97
0.27
3.5
4.2
35.56
52.14
mg/l
2.29
334
1761
16
65
1.24
0.27
1.2
1.3
28.43
28.08
%
—
7
12
39
173
1.13
0.27
1.1
1.1
—
—
—
0
0
1308
6451
1.02
0.27
2.6
3.0
10.41
10.40
g/l
0.04
1192
5957
36
205
0.88
0.27
1.1
1.2
—
—
—
0
0
36
205
0.88
0.27
1.1
1.2
—
—
—
0
0
36
205
0.88
0.27
1.1
1.2
—
—
—
0
0
384
1862
1.04
0.26
1.1
1.1
1.66
2.81
u/ml
0.98
90
490
156
829
0.94
0.26
1.3
1.4
—
—
—
0
0
9
36
1.26
0.26
1.0
1.1
—
—
—
0
0
40
178
1.13
0.26
3.1
2.1
—
—
—
0
0
33
145
1.14
0.26
1.2
2.3
1.33
4.17
ug/l
0.88
15
87
10
38
1.32
0.26
1.0
1.2
—
—
—
0
0
10
38
1.32
0.26
1.1
1.1
—
—
—
0
0
9
37
1.22
0.26
1.1
1.1
—
—
—
0
0
46
207
1.12
0.26
1.7
1.3
—
—
—
0
0
399
2072
0.97
0.25
3.4
4.2
2.76
2.78
ratio
0.01
42
155
2211
10961
1.02
0.25
2.1
2.0
—
—
—
0
0
1132
5579
1.02
0.25
1.4
1.4
—
—
—
0
0
650
3183
1.03
0.25
1.2
1.2
—
—
—
0
0
40
225
0.89
0.25
1.6
1.3
16.82
17.11
umol/l
0.13
33
199
154
816
0.95
0.24
2.0
2.0
—
7.93
—
0
9
5
18
1.40
0.24
1.4
1.3
—
—
—
0
0
198
949
1.05
0.24
1.6
1.6
56.57
53.93
%
0.38
122
599
118
557
1.06
0.24
1.2
1.2
—
—
—
0
0
638
3126
1.03
0.24
2.3
3.0
21.57
21.58
s
0.02
543
2717
251
1313
0.96
0.24
1.3
1.4
—
—
—
0
0
2034
10351
0.99
0.24
1.5
1.4
—
—
—
0
0
113
604
0.94
0.24
1.4
1.5
—
—
—
0
0
10
64
0.78
0.24
1.0
1.1
—
—
—
0
0
10
64
0.78
0.24
1.0
1.1
—
—
—
0
0
141
670
1.06
0.24
3.1
3.1
31.28
22.40
mu/l
0.76
130
628
70
324
1.09
0.24
1.1
1.1
—
—
—
0
0
34
151
1.13
0.24
1.3
1.4
—
—
—
0
0
134
636
1.06
0.23
1.4
1.4
0.78
1.20
u/ml
0.32
53
283
187
896
1.05
0.23
2.2
2.9
19.27
21.78
nmol/l
2.45
177
853
74
344
1.08
0.23
3.1
3.0
—
—
—
0
0
271
1311
1.04
0.23
1.3
1.2
—
—
—
0
0
5
20
1.26
0.23
1.0
1.1
—
—
—
0
0
144
686
1.05
0.23
1.1
1.1
5.08
2.45
u/ml
0.53
58
241
311
1509
1.04
0.22
1.1
1.1
11.01
12.28
au/ml
0.12
19
83
0
6
0.00
0.22
0.0
1.3
—
—
—
0
0
179
941
0.96
0.22
3.4
4.4
—
—
—
0
0
8
52
0.77
0.22
2.5
1.7
—
—
—
0
0
39
176
1.11
0.22
6.0
6.9
53.57
43.78
g/mol
0.25
34
162
0
7
0.00
0.22
0.0
9.6
—
—
—
0
0
0
7
0.00
0.22
0.0
1.0
—
—
—
0
0
0
7
0.00
0.22
0.0
1.6
—
—
—
0
0
0
7
0.00
0.22
0.0
1.0
—
—
—
0
0
7530
38010
0.99
0.21
4.1
4.3
—
—
—
0
0
454
2220
1.03
0.21
1.1
1.1
2.02
1.59
u/ml
0.29
186
948
6
24
1.26
0.21
1.0
1.1
—
—
—
0
0
14
58
1.21
0.20
1.0
1.1
—
—
—
0
0
11
68
0.81
0.20
1.1
1.2
—
—
—
0
0
4840
24152
1.01
0.20
1.6
1.5
—
—
—
0
0
797
4079
0.98
0.20
2.8
3.2
41.46
48.64
u/ml
0.46
763
3931
12
49
1.23
0.20
2.8
2.3
—
—
—
0
0
15
63
1.20
0.20
1.1
1.1
0.29
1.52
u/ml
—
8
46
1960
9734
1.01
0.20
1.8
1.8
—
—
—
0
0
6
26
1.16
0.19
1.3
1.3
1.45
1.28
%
—
6
26
6
26
1.16
0.19
1.0
1.0
—
—
—
0
0
6
26
1.16
0.19
1.0
1.0
—
—
—
0
0
6
26
1.16
0.19
2.5
1.9
—
—
—
0
0
51
278
0.92
0.19
1.7
1.7
134.97
134.40
au/ml
—
6
35
63
294
1.08
0.19
1.1
1.1
—
—
—
0
0
302
1564
0.97
0.19
1.2
1.3
394.29
117.00
titre
—
7
40
7
28
1.26
0.19
1.0
1.1
—
—
—
0
0
70
376
0.93
0.19
2.0
1.7
—
—
—
0
0
187
904
1.04
0.18
2.1
2.4
—
—
—
0
0
63
339
0.93
0.18
1.8
1.6
—
—
—
0
0
143
750
0.96
0.18
1.6
1.6
31.20
32.20
%
0.12
87
475
517
2653
0.98
0.17
1.1
1.1
4.77
5.12
u/ml
0.08
60
357
963
4764
1.02
0.17
1.4
1.4
25.62
24.30
iu/l
0.58
802
4075
22
125
0.88
0.17
1.1
1.4
53.17
50.56
%
0.08
12
59
22
125
0.88
0.17
1.2
1.3
—
—
—
0
0
108
570
0.95
0.17
1.2
1.2
—
—
—
0
0
23
130
0.89
0.17
1.5
1.4
29.57
65.55
g/l
0.41
13
108
101
482
1.05
0.17
1.0
1.1
—
—
—
0
0
355
1829
0.97
0.17
3.2
3.9
24.91
24.30
mmol/l
1.92
312
1620
8
35
1.15
0.17
1.0
1.0
—
—
—
0
0
28
156
0.90
0.16
1.4
1.3
71.58
95.91
mu/l
0.38
23
119
146
704
1.04
0.16
1.0
1.1
245.00
254.76
mg/l
0.21
120
634
46
214
1.08
0.16
1.2
1.3
—
—
—
0
0
1129
5599
1.01
0.16
2.2
2.2
11.71
11.72
nmol/l
0.01
994
5020
253
1235
1.03
0.15
1.7
1.7
—
—
—
0
0
1161
5760
1.01
0.15
2.5
3.0
66.87
66.41
g/l
1.31
1072
5315
7
45
0.78
0.15
1.0
1.0
—
—
—
0
0
19
84
1.14
0.15
1.2
1.2
—
—
—
0
0
19
84
1.14
0.15
1.7
1.5
—
—
—
0
0
150
726
1.04
0.15
1.1
1.2
38.84
40.03
mg/l
0.10
118
634
425
2091
1.02
0.15
1.9
2.0
10.21
11.20
mg/l
1.56
395
1963
404
1987
1.02
0.14
1.1
1.1
6.60
6.33
u/ml
0.10
221
1098
32
175
0.92
0.14
1.1
1.3
—
—
—
0
0
50
235
1.07
0.14
1.2
1.1
—
—
—
0
0
628
3105
1.02
0.14
1.8
1.7
—
—
—
0
0
35
162
1.09
0.14
1.1
1.1
0.68
0.66
umol/24h
0.13
19
90
418
2140
0.98
0.13
1.2
1.3
—
—
—
0
0
93
488
0.96
0.13
1.4
1.3
972.86
405.63
titre
—
7
32
12
70
0.86
0.13
1.2
1.1
—
—
—
0
0
102
534
0.96
0.13
1.6
1.7
20.79
24.91
umol/l
0.82
97
510
160
779
1.03
0.12
1.2
1.1
—
—
—
0
0
358
1833
0.98
0.12
1.2
1.3
—
—
—
0
0
12
52
1.16
0.11
1.5
1.2
138.14
86.73
ug/l
—
7
32
76
399
0.96
0.11
1.9
3.1
7.43
7.42
ph
0.74
24
121
21
116
0.91
0.11
2.2
2.2
2.88
3.45
ug/l
—
8
36
33
154
1.08
0.11
2.1
1.8
—
—
—
0
0
157
811
0.97
0.11
5.1
5.2
7.22
7.14
mmol/l
0.08
131
664
30
162
0.93
0.10
1.5
1.7
—
—
—
0
0
54
285
0.95
0.10
3.0
2.8
28.12
27.81
umol/l
0.08
44
221
197
967
1.02
0.10
3.4
2.8
—
—
—
0
0
23
106
1.09
0.10
1.1
1.1
—
—
—
0
0
48
254
0.95
0.10
1.4
1.7
8.39
9.77
ug/l
1.57
48
254
92
446
1.04
0.10
4.0
2.6
—
—
—
0
0
11
63
0.88
0.09
1.0
1.0
—
—
—
0
0
5
24
1.05
0.09
1.0
1.1
—
—
—
0
0
5
24
1.05
0.09
1.0
1.3
268.00
250.91
nmol/l
—
5
24
64
335
0.96
0.09
2.1
2.1
9.73
9.58
mg/l
0.07
48
274
19
87
1.10
0.09
1.2
1.3
—
—
—
0
0
19
87
1.10
0.09
1.1
1.1
1.84
1.66
umol/24h
0.44
19
87
696
3461
1.01
0.09
1.3
1.3
1.41
0.98
u/ml
0.34
56
298
41
217
0.95
0.08
1.2
1.2
—
—
—
0
0
143
736
0.98
0.08
1.3
1.4
27923.72
100790.03
e6/l
2.40
92
510
141
691
1.03
0.08
1.1
1.2
—
—
—
0
0
318
1573
1.02
0.08
2.3
2.6
0.79
0.83
nmol/l
0.40
262
1357
5
33
0.76
0.08
1.0
1.9
—
—
—
0
0
28
150
0.94
0.08
13.7
13.5
0.37
0.33
umol/l
0.28
28
141
139
715
0.98
0.08
1.2
1.2
—
—
—
0
0
6
36
0.84
0.08
1.5
3.7
—
0.00
—
0
6
10
57
0.88
0.08
1.4
1.8
—
—
—
0
0
39
206
0.95
0.08
1.4
1.3
11.41
5.61
u/ml
—
10
43
286
1415
1.02
0.08
3.6
4.0
—
—
—
0
0
3729
18793
1.00
0.07
3.6
3.8
—
—
—
0
0
1167
5900
0.99
0.07
3.9
5.3
84.64
97.35
ng/l
4.50
1017
5210
46
221
1.05
0.07
5.5
6.3
—
—
—
0
0
46
221
1.05
0.07
2.8
3.2
—
—
—
0
0
95
464
1.03
0.07
1.3
1.2
—
—
—
0
0
135
663
1.02
0.07
1.1
1.2
—
—
—
0
0
315
1561
1.01
0.07
1.1
1.1
2.88
3.93
u/ml
0.76
118
647
567
2821
1.01
0.07
3.5
3.8
0.29
0.32
g/l
0.24
244
1319
9
44
1.03
0.07
2.3
1.8
—
—
—
0
0
8
46
0.87
0.07
1.5
1.5
—
—
—
0
0
120
589
1.02
0.07
1.0
1.1
5.27
0.60
u/ml
0.46
16
105
321
1632
0.99
0.06
2.6
3.2
35.61
33.02
umol/l
0.40
281
1390
91
469
0.97
0.06
2.3
2.4
573.75
722.45
ml
2.72
55
328
511
2544
1.01
0.06
2.1
2.6
441.13
409.96
ug/l
0.10
480
2366
85
416
1.03
0.06
2.0
2.1
1.78
2.72
ug/l
2.43
74
348
32
153
1.05
0.06
1.3
1.7
112.04
122.09
ng/l
0.21
32
153
17
79
1.08
0.06
1.8
2.4
183.00
173.65
ug/g
0.10
17
71
118
581
1.02
0.05
1.0
1.1
—
—
—
0
0
71
366
0.97
0.05
2.3
2.5
500.53
504.35
min
0.12
49
288
98
482
1.02
0.05
1.3
1.7
33.16
34.28
mmol/l
0.18
88
419
151
770
0.98
0.05
3.2
3.5
—
—
—
0
0
31
149
1.05
0.04
1.3
1.2
701.34
135.49
ug/l
0.38
19
86
15
70
1.08
0.04
1.9
1.8
—
—
—
0
0
153
779
0.99
0.04
1.1
1.2
—
—
—
0
0
543
2744
0.99
0.04
1.6
1.6
250.00
327.55
titre
0.31
28
104
53
259
1.03
0.04
2.2
2.2
110.26
108.79
ng/l
0.04
40
170
235
1169
1.01
0.04
1.5
1.6
—
—
—
0
0
77
379
1.02
0.04
1.7
1.6
2.42
4.19
nmol/l
0.90
61
316
87
429
1.02
0.04
1.2
1.2
—
—
—
0
0
24
115
1.05
0.03
1.0
1.1
0.09
0.19
u/ml
0.34
17
71
22
116
0.95
0.03
3.6
3.1
—
—
—
0
0
93
475
0.98
0.03
1.4
1.3
51.82
67.95
titre
0.37
11
44
1017
5090
1.00
0.03
1.2
1.3
—
—
—
0
0
139
707
0.99
0.03
1.1
1.1
—
—
—
0
0
1186
5939
1.00
0.03
2.8
3.3
175.45
184.13
ng/l
0.25
1061
5421
14
75
0.94
0.03
1.1
1.1
—
—
—
0
0
666
3359
1.00
0.03
1.7
1.9
1.50
1.47
g/l
0.33
574
2902
420
2121
0.99
0.03
1.3
1.3
3.24
8.27
u/ml
1.49
50
196
31
161
0.97
0.03
2.1
2.3
—
—
—
0
0
2037
10212
1.00
0.03
6.1
8.6
1.05
1.07
mmol/l
2.26
1905
9645
431
2154
1.01
0.02
1.3
1.3
9.19
9.17
u/ml
0.00
80
301
257
1300
0.99
0.02
1.2
1.3
4.94
3.94
u/ml
0.36
112
612
251
1269
0.99
0.02
1.4
1.6
67.83
65.80
mmol/l
0.27
212
1022
287
1450
0.99
0.02
1.1
1.1
5.96
5.13
u/ml
0.26
114
628
64
327
0.98
0.02
1.8
2.2
—
—
—
0
0
28
136
1.03
0.02
1.1
1.1
18.26
5.47
u/ml
0.34
21
107
66
326
1.02
0.02
1.1
1.1
519.64
937.43
ng/l
0.33
17
60
621
3110
1.00
0.02
1.4
1.5
9.40
9.22
u/l
0.13
503
2506
688
3465
1.00
0.02
1.3
1.3
239.47
233.48
miu/ml
0.16
314
1622
130
648
1.01
0.01
4.6
5.5
11.48
11.18
%
0.38
130
648
795
4000
1.00
0.01
2.4
2.4
—
—
—
0
0
82
416
0.99
0.01
1.2
1.1
2.71
4.56
iu/ml
—
7
34
91
453
1.01
0.01
3.3
4.1
—
—
—
0
0
462
2326
1.00
0.01
1.3
1.3
53.01
28.07
u/ml
0.81
29
123
127
642
0.99
0.01
2.0
2.0
2.56
0.61
g/24h
—
8
34
2283
11474
1.00
0.01
2.2
2.7
29.83
29.56
s
1.25
2219
11136
123
614
1.01
0.00
1.5
1.4
11.37
11.86
umol/l
0.32
117
592
33
169
0.98
0.00
1.1
1.1
—
—
—
0
0
33
169
0.98
0.00
1.1
1.1
—
—
—
0
0
33
169
0.98
0.00
1.1
1.1
—
—
—
0
0
79
400
0.99
0.00
1.3
1.2
384.36
307.38
u/l
0.21
70
357
124
626
0.99
0.00
1.0
1.1
—
—
—
0
0
85
430
0.99
0.00
1.9
2.0
2.80
4.59
ug/l
1.87
77
383
16
78
1.03
0.00
1.4
1.2
—
—
—
0
0
22
109
1.01
0.00
1.0
1.1
—
—
—
0
0
28
143
0.98
0.00
1.4
1.5
359099.14
88040.99
nmol/l
0.33
22
117
65
324
1.01
0.00
1.8
2.1
—
—
—
0
0
134
673
1.00
0.00
1.1
1.1
14.24
4.71
u/ml
0.32
49
210
18
90
1.00
0.00
4.2
2.3
1.50
1.69
mg/l
0.12
13
60
83
414
1.01
0.00
1.3
1.3
—
—
—
0
0
71
359
0.99
0.00
1.1
1.2
6.63
11.65
u/ml
0.32
42
226
302
1514
1.00
0.00
1.3
1.3
—
—
—
0
0
125
627
1.00
0.00
1.2
1.1
—
—
—
0
0
320
1609
1.00
0.00
2.0
1.9
192.15
189.79
pmol/l
0.14
295
1534
31
155
1.00
0.00
1.1
1.3
21.87
80.57
ng/l
3.18
17
100
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
8
40
1.00
0.00
4.9
5.8
428.50
482.00
umol/l
—
8
40
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint K11_CARIES_3_OPER_ONLYAVO and mortality.

Females

Parameter HR [95% CI] p-value
K11_CARIES_3_OPER_ONLYAVO 0.773 [0.65, 0.92] 0.003
Birth year 0.996 [0.99, 1.0] 0.272

During the follow-up period (1.1.1998 — 31.12.2019), 16544 out of 868402 females with K11_CARIES_3_OPER_ONLYAVO died.

Males

Parameter HR [95% CI] p-value
K11_CARIES_3_OPER_ONLYAVO 0.731 [0.61, 0.87] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 20723 out of 752181 males with K11_CARIES_3_OPER_ONLYAVO died.

Mortality risk

Mortality risk for people of age

years, who have K11_CARIES_3_OPER_ONLYAVO.

N-year risk Females Males
1 0.051% 0.12%
5 0.365% 0.781%
10 0.998% 2.064%
15 2.072% 4.031%
20 3.689% 6.841%

Relationships between endpoints

Index endpoint: K11_CARIES_3_OPER_ONLYAVO – Dental caries 3 and operation codes, only avohilmo

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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