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Rheumatoid arthritis

M13_RHEUMA

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M05, M06
Hospital discharge: ICD-9 7140A|7140B|7241|7142
Hospital discharge: ICD-8 712[1-3]
Cause of death: ICD-10 M05, M06
Cause of death: ICD-9 7140A|7140B|7241|7142
Cause of death: ICD-8 712[1-3]

2 out of 7 registries used, show all original rules.

14002

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Check minimum number of events None

14002

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Include endpoints None

14002

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Remove individuals based on genotype QC

13620

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M13_RHEUMA

Control definitions

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Rheumatoid arthritis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 13620 9151 4469
Unadjusted prevalence (%) 3.31 3.97 2.46
Mean age at first event (years) 52.01 50.14 55.84

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.02 [1.64, 2.48] 1.9e-11 1895
15 years 0.01 1.56 [1.33, 1.82] 2.2e-8 873
5 years 0.00 2.25 [1.95, 2.59] 4.0e-29 393
1 year 0.00 3.28 [2.63, 4.08] 3.4e-26 108

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_RHEUMA – Rheumatoid arthritis
GWS hits: 25

Survival analyses between endpoints

Plot

before Rheumatoid arthritis
after Rheumatoid arthritis

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Drugs most likely to be purchased after Rheumatoid arthritis