spondylolisthesis: A condition in which there is forward displacement of a vertebral bone over the on below it.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
8211 |
4. Check minimum number of eventsNone |
8211 |
5. Include endpointsNone |
8211 |
6. Filter based on genotype QC (FinnGen only) |
8211 |
Control definitions (FinnGen only)
- Control exclude
- M13_DORSOPATHY
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to Spondylolisthesis/Spondylolysis based on the number of shared cases.
Similar with more cases:
- Deforming dorsopathies
- Dorsopathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 48651 | 28486 | 20045 |
Only index persons | 47184 | 27814 | 19370 |
Unadjusted period prevalence (%) | |||
Whole population | 0.71 | 0.82 | 0.56 |
Only index persons | 0.91 | 1.02 | 0.74 |
Median age at first event (years) | |||
Whole population | 54.63 | 57.47 | 50.61 |
Only index persons | 54.46 | 57.28 | 50.41 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 8211 | 5300 | 2911 |
Unadjusted period prevalence (%) | 1.62 | 1.81 | 1.28 |
Median age at first event (years) | 57.09 | 57.57 | 56.21 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 7270
- Matched controls
- 72700
LabWAS
↥Mortality – FinRegistry
↥Association
Association between endpoint M13_SPONDYLOLISTHESIS and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
M13_SPONDYLOLISTHESIS | 0.957 [0.86, 1.07] | 0.426 |
Birth year | 0.995 [0.99, 1.0] | 0.204 |
During the follow-up period (1.1.1998 — 31.12.2019), 2409 out of 24174 females with M13_SPONDYLOLISTHESIS died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
M13_SPONDYLOLISTHESIS | 1.056 [0.95, 1.18] | 0.323 |
Birth year | 0.989 [0.98, 1.0] | 0.018 |
During the follow-up period (1.1.1998 — 31.12.2019), 1963 out of 16826 males with M13_SPONDYLOLISTHESIS died.
Mortality risk
Mortality risk for people of age
years, who have M13_SPONDYLOLISTHESIS.N-year risk | Females | Males |
---|---|---|
1 | 0.082% | 0.238% |
5 | 0.591% | 1.269% |
10 | 1.443% | 3.212% |
15 | 2.637% | 6.173% |
20 | 4.882% | 10.728% |
Relationships between endpoints
↥Index endpoint: M13_SPONDYLOLISTHESIS – Spondylolisthesis/Spondylolysis
GWS hits: 7