Asthma

J10_ASTHMA

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None

321302

diagram downward connector

Check conditions None

321302

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493
Cause of death: ICD-10 J45, J46
Cause of death: ICD-9 493
Cause of death: ICD-8 493

33507

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

33502

diagram downward connector

Check minimum number of events None

33502

diagram downward connector

Include endpoints None

33502

diagram downward connector
J10_ASTHMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 32351 19875 12476
Unadjusted prevalence (%) 10.48 11.45 9.24
Mean age at first event (years) 44.81 43.55 46.82

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.98 [1.71, 2.29] 9.9e-20 3147
15 years 0.01 1.31 [1.15, 1.50] 7.2e-5 1437
5 years 0.00 2.41 [2.13, 2.71] 1.5e-46 805
1 year 0.00 5.40 [4.62, 6.31] 1.8e-99 353

Correlations

Index endpoint: J10_ASTHMA – Asthma
GWS hits: 27

Survival analyses between endpoints

Plot

before Asthma
after Asthma

loading spinner Loading survival analyses plot