No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
40434 |
4. Check minimum number of eventsNone |
40434 |
5. Include endpointsNone |
40434 |
6. Filter based on genotype QC (FinnGen only) |
40434 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF6v3
Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 371676 | 179635 | 191591 |
Only index persons | 334868 | 164824 | 170044 |
Unadjusted period prevalence (%) | |||
Whole population | 5.25 | 5.15 | 5.35 |
Only index persons | 6.28 | 6.06 | 6.49 |
Median age at first event (years) | |||
Whole population | 7.52 | 9.41 | 5.70 |
Only index persons | 8.76 | 11.26 | 6.35 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 40434 | 27252 | 13182 |
Unadjusted period prevalence (%) | 8.16 | 9.29 | 5.81 |
Median age at first event (years) | 16.48 | 16.67 | 16.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 16609
- Matched controls
- 143724
Mortality – FinRegistry
↥Association
Association between endpoint J10_TONSILLECTOMY and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_TONSILLECTOMY | 0.908 [0.8, 1.04] | 0.152 |
Birth year | 0.999 [0.99, 1.01] | 0.835 |
During the follow-up period (1.1.1998 — 31.12.2019), 1204 out of 148707 females with J10_TONSILLECTOMY died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
J10_TONSILLECTOMY | 1.159 [1.03, 1.31] | 0.018 |
Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2053 out of 158040 males with J10_TONSILLECTOMY died.
Mortality risk
Mortality risk for people of age
years, who have J10_TONSILLECTOMY.N-year risk | Females | Males |
---|---|---|
1 | 0.083% | 0.2% |
5 | 0.544% | 1.283% |
10 | 1.463% | 3.223% |
15 | 2.727% | 6.037% |
20 | 5.13% | 10.269% |
Relationships between endpoints
↥Index endpoint: J10_TONSILLECTOMY – Tonsillectomy and adenotomy
GWS hits: 37