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Age-related macular degeneration (whether dry or wet)

H7_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

FinnGen phenotype data

429209 individuals

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Apply sex-specific rule None

429209

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Check conditions None

429209

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

10058

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Remove individuals based on genotype QC

9721

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H7_AMD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 9721 5029 4692
Unadjusted prevalence (%) 2.36 2.18 2.58
Mean age at first event (years) 75.29 75.41 75.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 2.85 [2.31, 3.51] 1.0e-22 2228
15 years 0.01 1.48 [1.26, 1.75] 3.3e-6 993
5 years 0.00 2.73 [2.40, 3.10] 6.3e-54 886
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_AMD – Age-related macular degeneration (whether dry or wet)
GWS hits: 25

Survival analyses between endpoints

Plot

before Age-related macular degeneration (whether dry or wet)
after Age-related macular degeneration (whether dry or wet)

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Drugs most likely to be purchased after Age-related macular degeneration (whether dry or wet)