Psoriasis

L12_PSORIASIS

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 L40
Cause of death: ICD-10 L40

6928

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

6928

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Check minimum number of events None

6928

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L12_PSORIASIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L40-L45
Name in latin Psoriasis

Summary Statistics

Key figures

All Female Male
Number of individuals 6995 3677 3318
Unadjusted prevalence (%) 2.27 2.12 2.46
Mean age at first event (years) 49.25 48.11 50.50

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.03 [1.56, 2.63] 1.2e-7 545
15 years 0.01 1.58 [1.26, 1.98] 7.4e-5 296
5 years 0.00 2.18 [1.72, 2.76] 1.0e-10 117
1 year 0.00 3.25 [2.23, 4.74] 8.5e-10 33

Correlations

Index endpoint: L12_PSORIASIS – Psoriasis
GWS hits: 20

Survival analyses between endpoints

Plot

before Psoriasis
after Psoriasis

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