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Persons encountering health services for examination and investigation

Z21_PERSONS_ENCOUNTERI_HEALTH_SERVI_EXAM_INVES

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z00-Z13
  • Cause of death: ICD-10 Z00-Z13

2 out of 7 registries used, show all original rules.

245764

4. Check minimum number of events

None

245764

5. Include endpoints

245764

6. Filter based on genotype QC (FinnGen only)

235900

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z

Similar endpoints

List of similar endpoints to Persons encountering health services for examination and investigation based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 235900 145275 90625
Unadjusted period prevalence (%) 52.62 57.06 45.51
Median age at first event (years) 50.49 46.79 56.41

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
135
Matched controls
895
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z01.1
ICD-10 Finland
Examination of ears and hearing
+∞
22.0
24
*
Z01.8
ICD-10 Finland
Other specified special examinations
+∞
16.3
18
*
Z00.0
ICD-10 Finland
General medical examination
+∞
12.6
14
*
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
51.3
10.6
14
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
+∞
9.9
11
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
+∞
9.0
10
*
J01DB01
ATC
cefalexin; oral
3.9
8.4
40
87
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.6
8.4
23
27
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
+∞
8.0
9
*
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.2
7.9
34
67
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.0
7.7
61
192
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.8
7.4
36
79
M01AX05
ATC
glucosamine; oral
7.5
7.3
18
18
C07AB07
ATC
bisoprolol; oral
3.2
7.1
46
126
N02BE01
ATC
paracetamol; systemic, rectal
2.9
6.9
56
178

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_PERSONS_ENCOUNTERI_HEALTH_SERVI_EXAM_INVES – Persons encountering health services for examination and investigation

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).